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Dr Liz Holliday

Conjoint Associate Professor

School of Medicine and Public Health

Career Summary

Biography

Elizabeth (Liz) Holliday is a genetic statistician with training in molecular bioscience (BSc Hons I - 2003), genetic epidemiology (PhD - 2008) and statistics (MSc - 2012). She is a Senior Statistician in the Clinical Research Design, IT and Statistical Support (CReDITSS) Unit at the Hunter Medical Research Institute. In this role she provides epidemiological and statistical support and advice to clinical researchers.

Her research interests include statistical genetics, causal inference in observational epidemiology and longitudinal data analyses.

Liz has published over 70 journal articles and book chapters/sections. She has also received a number of nationally competive grants and awards for her research.

Research Expertise
Liz has research expertise in biostatistics, genetic epidemiology, human disease mapping, and traditional epidemiology. She has substantial experience in the design and conduct of genome-wide association studies of various complex diseases, particularly stroke, kidney disease, and eye disorders such as macular degeneration. She also has experience with more classical epidemiological research, including case-control and prospective cohort observational studies.

Teaching Expertise
2011-2012: Course Coordinator for BIOS6910 (Biostatistics A).

Collaborations
Liz collaborates with a variety of international genetics consortia including: - The International Stroke Genetics Consortium (ISGC). From 2012-2014 she chaired the central analysis group for the ISGC. - Cohorts for Heart and Aging Research In Genomic Epidemiology (CHARGE) consortium - The Chronic Kidney Disease Genetics (CKDGen) consortium - The Genetic Investigation of ANthropometric Traits (GIANT) consortium - the Social Science Genetic Association Consortium (SSGAC) Within Australia, Liz collaborates with the Australian Stroke Genetics Consortium (ASGC), the Blue Mountains Eye Study (BMES), the Cardiovascular Research Network (CVRN) and the Queensland Institute of Medical Research (QIMR), among others.


Qualifications

  • PhD, University of Queensland
  • Bachelor of Science (Honours), University of Queensland
  • Master of Science (Statistics), University of Queensland

Keywords

  • Biostatistics
  • Genetic association
  • Genetic epidemiology
  • Statistical genetics

Fields of Research

CodeDescriptionPercentage
010402Biostatistics35
060408Genomics30
060412Quantitative Genetics (incl. Disease and Trait Mapping Genetics)35

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/07/2014 - 14/11/2014Future Leaders FellowshipUniversity of Newcastle
School of Medicine and Public Health
Australia
1/08/2012 - 14/12/2012Casual AcademicUniversity of Newcastle
School of Medicine and Public Health
Australia
26/07/2010 - 17/12/2010Casual AcademicUniversity of Newcastle
School of Mathematical and Physical Sciences
Australia
14/09/2009 - 30/09/2010Brawn Postdoctoral FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/10/2010 - NHMRC Early Career Research FellowUniversity of Newcastle
School of Medicine and Public Health
Australia
1/01/2010 - 1/05/2014FellowshipUniversity of Newcastle
School of Medicine and Public Health
Australia
1/01/2010 - Membership - International Stroke Genetics ConsortiumInternational Stroke Genetics Consortium
Australia
1/09/2009 - 1/09/2010Gladys M Brawn Memorial Postdoctoral FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/03/2007 - 1/09/2009Research ScientistQueensland Government - Department of Health
Centre for Mental Health
Australia

Awards

Honours

YearAward
2013High Flyers Think Tank
Australian Academy of Science
2013High Flyers Think Tank
Australian Academy of Science
2012Star Graduate
Unknown
2012Star Graduate
Unknown
2002Dean's Commendation for High Achievement in Bachelor of Science
University of Queensland
2002Dean's Commendation for High Achievement in Bachelor of Science
University of Queensland

Research Award

YearAward
2013Career Development Award
International Stroke Genetics Consortium
2013Career Development Award
International Stroke Genetics Consortium
2011Best Platform (Oral) Presentation
Unknown
2011Peter Bladin New Investigator Award
Stroke Society of Australasia
2011Young Investigator Travel Award
Stroke Society of Australasia
2011Education Prize
Hunter Medical Research Institute
2011Best Platform (Oral) Presentation
Unknown
2011Peter Bladin New Investigator Award
Stroke Society of Australasia
2011Young Investigator Travel Award
Stroke Society of Australasia
2011Education Prize
Hunter Medical Research Institute
2007Best Student Poster Presentation
Unknown
2007Best Student Poster Presentation
Unknown
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (4 outputs)

YearCitationAltmetricsLink
2015Riveros C, Vimieiro R, Holliday EG, Oldmeadow C, Wang JJ, Mitchell P, et al., 'Identification of genome-wide snp¿snp and snp¿clinical boolean interactions in age-related macular degeneration', , Humana Press Inc. (2015)

We propose here a methodology to uncover modularities in the network of SNP¿SNP interactions most associated with disease. We start by computing all possible Boolean binary SNP interactions across the whole genome. By constructing a weighted graph of the most relevant interactions and via a combinatorial optimization approach, we fnd the most highly interconnected SNPs. We show that the method can be easily extended to fnd SNP/environment interactions. Using a modestly sized GWAS dataset of age-related macular degeneration (AMD), we identify a group of only 19 SNPs, which include those in previously reported regions associated to AMD. We also uncover a larger set of loci pointing to a matrix of key processes and functions that are affected. The proposed integrative methodology extends and overlaps traditional statistical analysis in a natural way. Combinatorial optimization techniques allow us to fnd the kernel of the most central interactions, complementing current methods of GWAS analysis and also enhancing the search for gene¿environment interaction.

DOI10.1007/978-1-4939-2155-3_12
Co-authorsChristopher Oldmeadow, Rodney Scott, John Attia, Pablo Moscato
2014Holliday EG, 'Sampling Error', Encyclopedia of Quality of Life and Well-Being Research, Springer, Dordrecht, Netherlands 5643-5645 (2014) [D2]
DOI10.1007/978-94-007-0753-5_2554
2014Holliday EG, 'Statistical Inference', Encyclopedia of Quality of Life and Well-Being Research, Springer, Dordrecht, Netherlands 3258-3262 (2014) [D2]
2013Holliday EG, Oldmeadow CJ, Maguire JM, Attia JR, 'Candidate gene association studies in stroke', Stroke Genetics, Springer Verlag, London 9-23 (2013) [B1]
Co-authorsChristopher Oldmeadow, John Attia, Jane Maguire
Show 1 more chapter

Journal article (77 outputs)

YearCitationAltmetricsLink
2015Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, et al., 'Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease', Neurology, 84 918-926 (2015)

Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. Methods: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that accounted for multiple testing and linkage disequilibrium between SNPs (p < 0.000084). Results: Three intronic SNPs in COL4A2 were significantly associated with deep intracerebral hemorrhage (lead SNP odds ratio [OR] 1.29, 95% confidence interval [CI] 1.14-1.46, p = 0.00003; r2 > 0.9 between SNPs). Although SNPs associated with deep intracerebral hemorrhage did not reach our significance threshold for association with lacunar ischemic stroke (lead SNP OR 1.10, 95% CI 1.03-1.18, p = 0.0073), and with white matter hyperintensity volume in symptomatic ischemic stroke patients (lead SNP OR 1.07, 95% CI 1.01-1.13, p = 0.016), the direction of association was the same. There was no convincing evidence of association with white matter hyperintensities in population-based studies or with non-small vessel disease cerebrovascular phenotypes. Conclusions: Our results indicate an association between common variation in the COL4A2 gene and symptomatic small vessel disease, particularly deep intracerebral hemorrhage. These findings merit replication studies, including in ethnic groups of non-European ancestry.

DOI10.1212/WNL.0000000000001309
Co-authorsJohn Attia, Chris Levi
2015Sapkota Y, Low S-K, Attia J, Gordon SD, Henders AK, Holliday EG, et al., 'Association between endometriosis and the interleukin 1A (ILIA) locus', HUMAN REPRODUCTION, 30 239-248 (2015)
DOI10.1093/humrep/deu267Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsRodney Scott, John Attia
2015Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, et al., 'New genetic loci link adipose and insulin biology to body fat distribution', Nature, 518 187-197 (2015)

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10-8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

DOI10.1038/nature14132
CitationsScopus - 6Web of Science - 4
2015Battey TWK, Valant V, Kassis SB, Kourkoulis C, Lee C, Anderson CD, et al., 'Recommendations from the international stroke genetics consortium, part 2: Biological sample collection and storage', Stroke, 46 285-290 (2015)
DOI10.1161/STROKEAHA.114.006851
CitationsScopus - 1Web of Science - 2
Co-authorsJane Maguire
2015Chan JPL, Thalamuthu A, Oldmeadow C, Armstrong NJ, Holliday EG, McEvoy M, et al., 'Genetics of hand grip strength in mid to late life', Age, 37 1-10 (2015)

Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been consistently identified. We aimed to identify single nucleotide polymorphisms (SNPs) associated with GS in middle-aged to older adults using a genome-wide association study (GWAS). GS was measured using handheld dynamometry in community-dwelling men and women aged 55¿85 from the Hunter Community Study (HCS, N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.

DOI10.1007/s11357-015-9745-5
Co-authorsRodney Scott, Christopher Oldmeadow, Roseanne Peel, John Attia
2015Hancock DB, Levy JL, Gaddis NC, Glasheen C, Saccone NL, Page GP, et al., 'Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.', Biol Psychiatry, (2015)
DOI10.1016/j.biopsych.2015.01.003Author URL
Co-authorsRodney Scott, John Attia
2015Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, et al., 'Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk', HUMAN MOLECULAR GENETICS, 24 1478-1492 (2015) [C1]
DOI10.1093/hmg/ddu552Author URL
Co-authorsJohn Attia, Rodney Scott, Katie Ashton
2015Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, et al., 'Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).', Mol Psychiatry, 20 183-192 (2015)
DOI10.1038/mp.2014.188Author URL
CitationsWeb of Science - 1
Co-authorsJohn Attia, Rodney Scott, Christopher Oldmeadow, Peter Schofield
2015Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al., 'Genetic studies of body mass index yield new insights for obesity biology.', Nature, 518 197-206 (2015)
DOI10.1038/nature14177Author URL
CitationsScopus - 10Web of Science - 7
2015Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, et al., 'Genetic overlap between diagnostic subtypes of ischemic stroke.', Stroke, 46 615-619 (2015)
DOI10.1161/STROKEAHA.114.007930Author URL
Co-authorsChris Levi, Jane Maguire, Christopher Oldmeadow, Rodney Scott, John Attia, Lisa Lincz
2015Gorski M, Tin A, Garnaas M, McMahon GM, Chu AY, Tayo BO, et al., 'Genome-wide association study of kidney function decline in individuals of European descent', KIDNEY INTERNATIONAL, 87 1017-1029 (2015) [C1]
DOI10.1038/ki.2014.361Author URL
CitationsScopus - 2
2015Malik R, Freilinger T, Winsvold BS, Anttila V, Vander Heiden J, Traylor M, et al., 'Shared genetic basis for migraine and ischemic stroke', Neurology, 84 2132-2145 (2015)

Objective: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. Methods: We applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,425 controls) and IS (12,389 cases and 62,004 controls). First, we queried known genome-wide significant loci for both disorders, looking for potential overlap of signals. We then analyzed the overall shared genetic load using polygenic scores and estimated the genetic correlation between disease subtypes using data derived from these models. We further interrogated genomic regions of shared risk using analysis of covariance patterns between the 2 phenotypes using cross-phenotype spatial mapping. Results: We found substantial genetic overlap between migraine and IS using all 4 approaches. Migraine without aura (MO) showed much stronger overlap with IS and its subtypes than migraine with aura (MA). The strongest overlap existed between MO and large artery stroke (LAS; p 6.4 × 10-28 for the LAS polygenic score in MO) and between MO and cardioembolic stroke (CE; p 2.7 × 10-20 for the CE score in MO). Conclusions: Our findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms. Our observations on MA are consistent with a limited role of common genetic variants in this subtype.

DOI10.1212/WNL.0000000000001606
CitationsScopus - 1Web of Science - 1
Co-authorsJane Maguire
2015Gorski M, Tin A, Garnaas M, McMahon GM, Chu AY, Tayo BO, et al., 'Genome-wide association study of kidney function decline in individuals of European descent.', Kidney international, 87 1017-1029 (2015) [C1]
DOI10.1038/ki.2014.361
CitationsScopus - 2
2015Achterberg S, Kappelle LJ, De Bakker PIW, Traylor M, Algra A, Van Der Graaf Y, et al., 'No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study', PLoS ONE, 10 (2015)

Background: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that cerebral ischemia has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. Methods and Results: We studied 1020 patients with cerebral ischemia and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new ischemic events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of ischemic stroke (using summary statistics from the METASTROKE study which included 12389 cases and 62004 controls), the AUC-ROC remained the same. Similar results were found for the secondary outcome ischemic stroke. Conclusions: We found no additional value of genetic information in a prognostic model for the risk of ischemic events in patients with cerebral ischemia of arterial origin. This is consistent with a complex, polygenic architecture, where many genes of weak effect likely act in concert to influence the heritable risk of an individual to develop (recurrent) vascular events. At present, genetic information cannot help clinicians to distinguish patients at high risk for recurrent vascular events.

DOI10.1371/journal.pone.0119203
2015Denham JW, Steigler A, Joseph D, Lamb DS, Spry NA, Duchesne G, et al., 'Radiation dose escalation or longer androgen suppression for locally advanced prostate cancer? Data from the TROG 03.04 RADAR trial.', Radiother Oncol, (2015)
DOI10.1016/j.radonc.2015.05.016Author URL
Co-authorsJohn Attia, Allison Steigler, Christopher Oldmeadow
2015Abdullah N, Abdul Murad NA, Attia J, Oldmeadow C, Mohd Haniff EA, Syafruddin SE, et al., 'Characterizing the genetic risk for Type 2 diabetes in a Malaysian multi-ethnic cohort.', Diabet Med, (2015)
DOI10.1111/dme.12735Author URL
Co-authorsChristopher Oldmeadow, John Attia
2015Sapkota Y, Attia J, Gordon SD, Henders AK, Holliday EG, Rahmioglu N, et al., 'Genetic burden associated with varying degrees of disease severity in endometriosis.', Mol Hum Reprod, 21 594-602 (2015)
DOI10.1093/molehr/gav021Author URL
Co-authorsJohn Attia
2015Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, et al., 'GWAS for executive function and processing speed suggests involvement of the CADM2 gene.', Mol Psychiatry, (2015)
DOI10.1038/mp.2015.37Author URL
Co-authorsJohn Attia, Peter Schofield
2014Oldmeadow C, Mossman D, Evans TJ, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1]
DOI10.1016/j.jpsychires.2014.01.011Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsMurray Cairns, Rodney Scott, Christopher Oldmeadow, Paul Tooney, John Attia
2014Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor C-C, Loomis SJ, et al., 'Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process', Nature Communications, 5 (2014) [C1]

Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition.

DOI10.1038/ncomms5883
CitationsScopus - 8
Co-authorsJohn Attia, Rodney Scott
2014Traylor M, Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, et al., 'A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.', PLoS Genet, 10 e1004469 (2014) [C1]
DOI10.1371/journal.pgen.1004469Author URL
CitationsScopus - 4Web of Science - 4
Co-authorsChris Levi, John Attia, Jane Maguire
2014Evans TJ, Milne E, Anderson D, de Klerk NH, Jamieson SE, Talseth-Palmer BA, et al., 'Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.', PLoS One, 9 e110255 (2014) [C1]
DOI10.1371/journal.pone.0110255Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsRodney Scott, Bente Talseth-Palmer, Nikola Bowden, John Attia
2014Holliday EG, Attia J, Hancock S, Koloski N, McEvoy M, Peel R, et al., 'Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome', American Journal of Gastroenterology, 109 770-772 (2014) [C1]
DOI10.1038/ajg.2014.56
CitationsScopus - 2Web of Science - 1
Co-authorsJohn Attia, Roseanne Peel, Rodney Scott, Nicholas Talley
2014Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, et al., 'Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12', NEUROLOGY, 83 678-685 (2014) [C1]
Author URL
CitationsScopus - 11Web of Science - 12
Co-authorsChris Levi
2014Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, et al., 'Polygenic Overlap Between Kidney Function and Large Artery Atherosclerotic Stroke', STROKE, 45 3508-+ (2014) [C1]
DOI10.1161/STROKEAHA.114.006609Author URL
Co-authorsChris Levi, John Attia, Rodney Scott, Jane Maguire, Christopher Oldmeadow
2014Malik R, Bevan S, Nalls MA, Holliday EG, Devan WJ, Cheng Y-C, et al., 'Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies', Stroke, 45 394-402 (2014) [C1]

Background and Purpose - Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts. Methods - Three thousand five hundred forty-eight clinic-based IS cases and 6399 controls from the Wellcome Trust Case Control Consortium 2 were used for derivation of the GRS. Subjects from the METASTROKE consortium served as a replication sample. The validation sample consisted of 22 751 participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. We selected variants that had reached genome-wide significance in previous association studies on established risk factors for IS. Results - A combined GRS for atrial fibrillation, coronary artery disease, hypertension, and systolic blood pressure significantly associated with IS both in the case-control samples and in the prospective population-based studies. Subjects in the top quintile of the combined GRS had >2-fold increased risk of IS compared with subjects in the lowest quintile. Addition of the combined GRS to a simple model based on sex significantly improved the prediction of IS in the combined clinic-based samples but not in the population-based studies, and there was no significant improvement in net reclassification. Conclusions - A multilocus GRS based on common variants for established cardiovascular risk factors was significantly associated with IS both in clinic-based samples and in the general population. However, the improvement in clinical risk prediction was found to be small. © 2014 American Heart Association, Inc.

DOI10.1161/STROKEAHA.113.002938
CitationsScopus - 9Web of Science - 5
Co-authorsChris Levi
2014Cotlarciuc I, Malik R, Holliday EG, Ahmadi KR, Paré G, Psaty BM, et al., 'Effect of genetic variants associated with plasma homocysteine levels on stroke risk', Stroke, 45 1920-1924 (2014) [C1]

BACKGROUND AND PURPOSE - : Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes. METHODS - : Previous meta-analysis results from an international stroke collaborative network, METASTROKE, were used to assess association of the 18 tHcy-associated single-nucleotide polymorphisms (SNPs) in 12 389 IS cases and 62 004 controls. We also investigated the associations in regions located within 50 kb from the 18 tHcy-related SNPs and the association of a genetic risk score, including the 18 SNPs. RESULTS - : One SNP located in the RASIP1 gene and a cluster of 3 SNPs located at and near SLC17A3 were significantly associated with IS (P<0.0003) after correcting for multiple testing. For stroke subtypes, the sentinel SNP located upstream of MUT was significantly associated with small-vessel disease (P=0.0022), whereas 1 SNP located in MTHFR was significantly associated with large-vessel disease (P=0.00019). A genetic risk score, including the 18 SNPs, did not show significant association with IS or its subtypes. CONCLUSIONS - : This study found several potential associations with IS and its subtypes: An association of an MUT variant with small-vessel disease, an MTHFR variant with large-vessel disease, and associations of RASIP1 and SLC17A3 variants with overall IS. © 2014 American Heart Association, Inc.

DOI10.1161/STROKEAHA.114.005208
CitationsScopus - 1Web of Science - 1
2014Wang JJ, Buitendijk GHS, Rochtchina E, Lee KE, Klein BEK, Van Duijn CM, et al., 'Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations', Ophthalmology, 121 667-675 (2014)
DOI10.1016/j.ophtha.2013.10.017
CitationsScopus - 2
Co-authorsWayne Smith, John Attia
2014Wang JJ, Buitendijk GHS, Rochtchina E, Lee KE, Klein BEK, Van Duijn CM, et al., 'Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations', Ophthalmology, 121 667-675 (2014) [C1]

Objective To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk. Design Pooled data analysis of population-based cohorts. Participants Participants from the Blue Mountains Eye Study (BMES) and Rotterdam Study (RS). Methods Dietary intakes of antioxidants (lutein/zeaxanthin [LZ], ß-carotene, and vitamin C), long-chain omega-3 polyunsaturated fatty acids, and zinc were estimated from food frequency questionnaires. The AMD genetic risk was classified according to the number of risk alleles of CFH (rs1061170) or ARMS2 (rs10490924) as low (no or 1 risk allele) or high (=2 risk alleles). Interactions between dietary intake and genetic risk levels were assessed. Associations between dietary intake and AMD risk were assessed comparing the highest with the 2 lower intake tertiles by genetic risk subgroups using discrete logistic regression, conducted in each study separately and then using pooled data. Participants without AMD lesions at any visit were controls. We adjusted for age and sex in analyses of each cohort sample and for smoking status and study site in pooled-data analyses. Main Outcome Measures All 15-year incident late AMD cases were confirmed by chief investigators of the Beaver Dam Eye Study, BMES, and RS. Intergrader reproducibility was assessed in an early AMD subsample, with 86.4% agreement between BMES and RS graders, allowing for a 1-step difference on a 5-step AMD severity scale. Results In pooled data analyses, we found significant interaction between AMD genetic risk status and LZ intake (P = 0.0009) but nonsignificant interactions between genetic risk status and weekly fish consumption (P = 0.05) for risk of any AMD. Among participants with high genetic risk, the highest intake tertile of LZ was associated with a >20% reduced risk of early AMD, and weekly consumption of fish was associated with a 40% reduced risk of late AMD. No similar association was evident among participants with low genetic risk. No interaction was detected between ß-carotene or vitamin C and genetic risk status. Conclusions Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions. ©2014 by the American Academy of Ophthalmology.

DOI10.1016/j.ophtha.2013.10.017
CitationsScopus - 3Web of Science - 5
Co-authorsWayne Smith, John Attia
2014De Vivo I, Prescott J, Setiawan VW, Olson SH, Wentzensen N, Attia J, et al., 'Genome-wide association study of endometrial cancer in E2C2', HUMAN GENETICS, 133 211-224 (2014) [C1]
DOI10.1007/s00439-013-1369-1Author URL
CitationsScopus - 4Web of Science - 6
Co-authorsJohn Attia, Rodney Scott
2014Moir-Meyer GL, Pearson JF, Lose F, The ANECSG, Scott RJ, McEvoy M, et al., 'Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition', Human Genetics, (2014)

Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk factors for this disease. This is the first genome-wide study to explore the role of common and rare germline copy number variants (CNVs) in predisposition to endometrial cancer. CNVs were called from germline DNA of 1,209 endometrioid endometrial cancer cases and 528 cancer-unaffected female controls. Overall CNV load of deletions or DNA gains did not differ significantly between cases and controls (P > 0.05), but cases presented with an excess of rare germline deletions overlapping likely functional genomic regions including genes (P = 8 × 10-10), CpG islands (P = 1 × 10-7) and sno/miRNAs regions (P = 3 × 10-9). On average, at least one additional gene and two additional CpG islands were disrupted by rare deletions in cases compared to controls. The most pronounced difference was that over 30 sno/miRNAs were disrupted by rare deletions in cases for every single disruption event in controls. A total of 13 DNA repair genes were disrupted by rare deletions in 19/1,209 cases (1.6 %) compared to one gene in 1/528 controls (0.2 %; P = 0.007), and this increased DNA repair gene loss in cases persisted after excluding five individuals carrying CNVs disrupting mismatch repair genes MLH1, MSH2 and MSH6 (P = 0.03). There were 34 miRNA regions deleted in at least one case but not in controls, the most frequent of which encompassed hsa-mir-661 and hsa-mir-203. Our study implicates rare germline deletions of functional and regulatory regions as possible mechanisms conferring endometrial cancer risk, and has identified specific regulatory elements as candidates for further investigation.

DOI10.1007/s00439-014-1507-4
Co-authorsRodney Scott, John Attia
2014Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT study (vol 73, pg 16, 2013)', ANNALS OF NEUROLOGY, 75 166-167 (2014)
DOI10.1002/ana.24105Author URL
Co-authorsRodney Scott, Chris Levi, John Attia
2014Moayyeri A, Hsu Y-H, Karasik D, Estrada K, Xiao S-M, Nielson C, et al., 'Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium', HUMAN MOLECULAR GENETICS, 23 3054-3068 (2014) [C1]
DOI10.1093/hmg/ddt675Author URL
CitationsScopus - 4Web of Science - 3
Co-authorsChristopher Oldmeadow, John Attia, Roseanne Peel, Rodney Scott
2014Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, et al., 'Genome-wide association analysis identifies six new loci associated with forced vital capacity', NATURE GENETICS, 46 669-677 (2014) [C1]
DOI10.1038/ng.3011Author URL
CitationsScopus - 6Web of Science - 6
Co-authorsJohn Attia, Rodney Scott, Christopher Oldmeadow
2014Oldmeadow C, Holliday EG, McEvoy M, Scott R, Kwok JBJ, Mather K, et al., 'Concordance between direct and imputed APOE genotypes using 1000 genomes data', Journal of Alzheimer's Disease, 42 391-393 (2014) [C1]

There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not included in any of the common microarray platforms. We compared directly measured APOE genotypes with those imputed using microarray data and the '1000 Genomes' dataset in a sample of 320 Caucasians. We find 90% agreement for e2/e3/e4 genotypes and 93% agreement for predicting e4 status, yielding kappa values of 0.81 and 0.84, respectively. More stringent thresholds around allele number estimates can increase this agreement to 90-97% and kappas of 0.90-0.93.

DOI10.3233/JAD-140846
Co-authorsPeter Schofield, John Attia, Rodney Scott, Christopher Oldmeadow
2014Abdullah N, Attia J, Oldmeadow C, Scott RJ, Holliday EG, 'The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings', INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, (2014) [C1]
DOI10.1155/2014/593982Author URL
CitationsScopus - 2
Co-authorsJohn Attia, Rodney Scott, Christopher Oldmeadow
2014Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, 'Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12', Neurology, 83 678-685 (2014) [C1]

Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p 5 7.12 3 10-11) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p 5 0.695).

CitationsScopus - 11Web of Science - 12
Co-authorsChris Levi
2014Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera NV, et al., 'Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.', Gut, (2014)
DOI10.1136/gutjnl-2014-307997Author URL
Co-authorsNicholas Talley
2013Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, et al., 'Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium', Biological Psychiatry, (2013)

Background: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting. Methods: We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia- and stroke-free individuals of European descent, aged =45 years. Replication of suggestive associations (p < 5 × 10-6) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. Results: rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 × 10-10) and replication cohorts (p = 5.65 × 10-8). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 × 10-8, and rs6813517 [SPOCK3], p = 2.58 × 10-8) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism. Conclusions: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.

DOI10.1016/j.biopsych.2014.08.027
Co-authorsPeter Schofield, Christopher Oldmeadow, John Attia
2013Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, et al., 'Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke', Stroke, 44 2703-2709 (2013) [C1]
DOI10.1161/STROKEAHA.113.002186Author URL
CitationsScopus - 3Web of Science - 3
Co-authorsJane Maguire, John Attia, Rodney Scott
2013Adib-Samii P, Rost N, Traylor M, Devan W, Biffi A, Lanfranconi S, et al., '17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status', Stroke, 44 1609-1615 (2013) [C1]
CitationsScopus - 11Web of Science - 13
Co-authorsJane Maguire, Chris Levi
2013Buitendijk GHS, Rochtchina E, Myers C, Van Duijn CM, Lee KE, Klein BEK, et al., 'Prediction of age-related macular degeneration in the general population: The three continent AMD consortium', Ophthalmology, 120 2644-2655 (2013) [C1]
DOI10.1016/j.ophtha.2013.07.053
CitationsScopus - 12Web of Science - 13
Co-authorsJohn Attia
2013Schache M, Richardson AJ, Mitchell P, Wang JJ, Rochtchina E, Viswanathan AC, et al., 'Genetic association of refractive error and axial length with 15q14 but not 15q25 in the Blue Mountains Eye Study Cohort', Ophthalmology, 120 292-297 (2013) [C1]
CitationsScopus - 6Web of Science - 4
Co-authorsRodney Scott, John Attia
2013Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT Study', Annals of Neurology, 73 16-31 (2013) [C1]
CitationsScopus - 19Web of Science - 19
Co-authorsRodney Scott, John Attia, Chris Levi
2013Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, De Andrade M, et al., 'Common variants in mendelian kidney disease genes and their association with renal function', Journal of the American Society of Nephrology, 24 2105-2117 (2013) [C1]

Many common genetic variants identified by genome-wide association studies for complex traitsmap to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidney function in the general population. Using the Online Mendelian Inheritance in Man database, we identified 731 unique disease entries related to specific renal search terms and confirmed a kidney phenotype in 218 of these entries, corresponding to mutations in 258 genes. We interrogated common SNPs (minor allele frequency >5%) within these genes for association with the estimated GFR in 74,354 European-ancestry participants from the CKDGen Consortium. However, the top four candidate SNPs (rs6433115 at LRP2, rs1050700 at TSC1, rs249942 at PALB2, and rs9827843 at ROBO2) did not achieve significance in a stage 2meta-analysis performed in 56,246 additional independent individuals, indicating that these common SNPs are not associated with estimated GFR. The effect of less common or rare variants in these genes on kidney function in the general population and disease-specific cohorts requires further research. Copyright © 2013 by the American Society of Nephrology.

DOI10.1681/ASN.2012100983
CitationsScopus - 4Web of Science - 2
2013Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al., 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations', Nature Genetics, 45 145-154 (2013) [C1]
CitationsScopus - 66Web of Science - 67
Co-authorsJohn Attia, Rodney Scott, Christopher Oldmeadow
2013Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, et al., 'GWAS of 126,559 individuals identifies genetic variants associated with educational attainment', Science, 340 1467-1471 (2013) [C1]
CitationsScopus - 62Web of Science - 64
Co-authorsJohn Attia, Rodney Scott, Christopher Oldmeadow
2013Magee CA, Holliday EG, Attia JR, Kritharides L, Banks E, 'Investigation of the relationship between sleep duration, all-cause mortality, and preexisting disease', Sleep Medicine, 14 591-596 (2013) [C1]
CitationsScopus - 6Web of Science - 5
Co-authorsJohn Attia
2013Stambolian D, Wojciechowski R, Oexle K, Pirastu M, Li X, Raffel LJ, et al., 'Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error', Human Molecular Genetics, 22 2754-2764 (2013) [C1]
CitationsScopus - 12Web of Science - 12
Co-authorsRodney Scott, John Attia
2013Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Avery-Kiejda KA, Scott RJ, 'STaRRRT: a table of short tandem repeats in regulatory regions of the human genome', BMC GENOMICS, 14 (2013) [C1]
DOI10.1186/1471-2164-14-795Author URL
CitationsScopus - 4Web of Science - 5
Co-authorsKelly Kiejda, Rodney Scott, Nikola Bowden
2013Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'Continuing difficulties in interpreting CNV data: Lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients', BMC Medical Genomics, 6 1-13 (2013) [C1]
CitationsScopus - 3Web of Science - 3
Co-authorsBente Talseth-Palmer, Rodney Scott, John Attia
2013Holliday EG, Magee CA, Kritharides L, Banks E, Attia J, 'Short Sleep Duration Is Associated with Risk of Future Diabetes but Not Cardiovascular Disease: a Prospective Study and Meta-Analysis', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0082305Author URL
CitationsScopus - 10Web of Science - 10
Co-authorsJohn Attia
2013Sun C, Young TL, Mackey DA, Van Zuydam NR, Doney ASF, Palmer CNA, et al., 'Genetic loci for retinal arteriolar microcirculation', PLoS One, 8 e65804 (2013) [C1]
CitationsScopus - 2Web of Science - 2
Co-authorsRodney Scott, John Attia
2013Jensen RA, Sim X, Li X, Cotch MF, Ikram MK, Holliday EG, et al., 'Genome-wide association study of retinopathy in individuals without diabetes', PLoS One, 8 e54232 (2013) [C1]
CitationsScopus - 4Web of Science - 5
Co-authorsRodney Scott, John Attia
2013Holliday EG, Smith AV, Cornes BK, Buitendijk GHS, Jensen RA, Sim X, et al., 'Insights into the genetic architecture of early stage age-related macular degeneration: A genome-wide association study meta-analysis', PLoS One, 8 e53830 (2013) [C1]
CitationsScopus - 27Web of Science - 26
Co-authorsRodney Scott, John Attia
2013Holliday EG, 'Hints of unique genetic effects for type 2 diabetes in India', Diabetes, 62 1369-1370 (2013) [C1]
CitationsScopus - 2Web of Science - 3
2012Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, et al., 'Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke?', Stroke, 43 980-U143 (2012) [C1]
CitationsScopus - 11Web of Science - 11
Co-authorsPablo Moscato, Lisa Lincz, Jane Maguire, Rodney Scott, John Attia, Chris Levi
2012Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, et al., 'Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke', Nature Genetics, 44 328-333 (2012) [C1]
DOI10.1038/ng.1081
CitationsScopus - 111Web of Science - 89
Co-authorsJohn Attia, Chris Levi
2012Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Genome-wide association meta-analysis identifies new endometriosis risk loci', Nature Genetics, 44 1355-1359 (2012) [C1]
CitationsScopus - 54Web of Science - 46
Co-authorsJohn Attia, Rodney Scott
2012Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm J, et al., 'Common variants at 6p21.1 are associated with large artery atherosclerotic stroke', Nature Genetics, 44 1147-1153 (2012) [C1]
CitationsScopus - 44Web of Science - 44
Co-authorsJane Maguire, Lisa Lincz, Pablo Moscato, John Attia, Mark Parsons, Roseanne Peel, Rodney Scott, Christopher Oldmeadow, Chris Levi, Wayne Smith
2012Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, et al., 'Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations', Nature Genetics, 44 904-909 (2012) [C1]
CitationsScopus - 33Web of Science - 39
Co-authorsRodney Scott, Christopher Oldmeadow, John Attia
2012Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Boger CA, Endlich K, et al., 'Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function', Human Molecular Genetics, 21 5329-5343 (2012) [C1]
CitationsScopus - 17Web of Science - 16
2012Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng Y-C, et al., 'Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies', The Lancet Neurology, 11 951-962 (2012) [C1]
CitationsScopus - 86Web of Science - 87
Co-authorsChris Levi, Jane Maguire
2012Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, et al., 'Genome-wide association and functional follow-up reveals new loci for kidney function', PLOS Genetics, 8 1-15 (2012) [C1]
CitationsScopus - 41Web of Science - 41
2012McAuley E, Scimone A, Tiwari Y, Agahi G, Mowry B, Holliday EG, et al., 'Identification of Sialyltransferase 8B as a Generalized Susceptibility Gene for Psychotic and Mood Disorders on Chromosome 15q25-26', PLoS One, 7 3817-3818 (2012) [C1]
CitationsScopus - 15
2011Oldmeadow CJ, Riveros RC, Holliday EG, Scott R, Moscato PA, Wang JJ, et al., 'Sifting the wheat from the chaff: Prioritizing GWAS results by identifying consistency across analytical methods', Genetic Epidemiology, 35 745-754 (2011) [C1]
DOI10.1002/gepi.20622
CitationsScopus - 5Web of Science - 5
Co-authorsJohn Attia, Rodney Scott, Christopher Oldmeadow, Pablo Moscato
2011Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, et al., 'Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease', Nature Genetics, 43 1241-1248 (2011) [C1]
CitationsScopus - 78Web of Science - 74
Co-authorsRodney Scott, John Attia
2010Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, et al., 'Four Novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In Vivo', Plos Genetics, 6 1-12 (2010) [C1]
DOI10.1371/journal.pgen.1001184
CitationsScopus - 54Web of Science - 50
Co-authorsJohn Attia, Rodney Scott
2010Holliday EG, Scott R, Attia JR, 'Evidence-based medicine in the era of biomarkers: Teaching a new dog old tricks?', Clinical Pharmacology and Therapeutics, 88 740-742 (2010) [C2]
DOI10.1038/clpt.2010.214
CitationsScopus - 4Web of Science - 2
Co-authorsJohn Attia, Rodney Scott
2009Holliday EG, Nyholt DR, Tirupati S, John S, Ramachandran P, Ramamurti M, et al., 'Strong evidence for a novel schizophrenia risk locus on chromosome 1p31.1 in homogeneous pedigrees from Tamil Nadu, India', American Journal of Psychiatry, 166 206-215 (2009) [C1]
DOI10.1176/appi.ajp.2008.08030442
CitationsScopus - 7Web of Science - 8
2009Psychiatric Gwas Consortium CC, Holliday EG, Cichon S, Craddock N, Daly M, Faraone S, et al., 'Genomewide association studies: history, rationale, and prospects for psychiatric disorders', American Journal of Psychiatry, 166 540-546 (2009) [C1]
CitationsScopus - 241
2009Holliday EG, McLean DE, Nyholt DR, Mowry BJ, 'Susceptibility locus on chromosome 1q23-25 for a schizophrenia subtype resembling deficit schizophrenia identified by latent class analysis', Archives of General Psychiatry, 66 1058-1067 (2009) [C1]
DOI10.1001/archgenpsychiatry.2009.136
CitationsScopus - 15
2009Thara R, Tirupati S, John S, Nancarrow D, Chant D, Holliday E, Mowry B, 'Design and clinical characteristics of a homogeneous schizophrenia pedigree sample from Tamil Nadu, India', Australian and New Zealand Journal of Psychiatry, 43 561-570 (2009) [C1]
DOI10.1080/00048670902873631
CitationsScopus - 2Web of Science - 3
2009Jones AL, Holliday EG, Mowry BJ, McLean DE, McGrath JJ, Pender MP, Greer JM, 'CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia', Brain Behavior and Immunity, 23 347-350 (2009) [C1]
DOI10.1016/j.bbi.2008.09.008
CitationsScopus - 7Web of Science - 7
2008Holliday EG, Mowry BJ, Nyholt DR, 'A reanalysis of 409 European-ancestry and African American schizophrenia pedigrees reveals significant linkage to 8p23.3 with evidence of locus heterogeneity', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147 1080-1088 (2008) [C1]
DOI10.1002/ajmg.b.30722
CitationsScopus - 4
2006Handoko HY, James MR, McGrath JJ, Nertney DA, Tirupati S, Thara R, et al., 'Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples', Twin Research and Human Genetics, 9 531-539 (2006) [C1]
DOI10.1375/183242706778025035
CitationsScopus - 18Web of Science - 16
2005Holliday EG, Mowry B, Chant D, Nyholt D, 'The importance of modelling heterogeneity in complex disease: Application to NIMH Schizophrenia Genetics Initiative data', Human Genetics, 117 160-167 (2005) [C1]
DOI10.1007/s00439-005-1282-3
Show 74 more journal articles

Conference (16 outputs)

YearCitationAltmetricsLink
2014Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Avery-Kiejda KA, Scott RJ, 'Short tandem repeats are variable genetic elements that may have major consequences for multiple diseases.', The Australian Society for Medical Research (ASMR) Satellite Scientific Meeting Programme, Newcastle, NSW, Australia (2014)
Co-authorsRodney Scott, Kelly Kiejda, Nikola Bowden
2014Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Kiejda KA, Scott RJ, 'Short tandem repeats are variable genetic elements that may have major consequences for multiple diseases.', The Australian Society for Medical Research (ASMR) Satellite Scientific Meeting Programme, Newcastle, NSW, Australia (2014) [E3]
Co-authorsRodney Scott, Nikola Bowden, Kelly Kiejda
2014Mather KA, Thalamuthu A, Oldmeadow C, Song F, Armstrong NJ, Poljak A, et al., 'Genome-wide significant results identified for plasma apolipoprotein h levels', Alzheimer's & Dementia (2014) [E3]
DOI10.1016/j.jalz.2014.05.1526
Co-authorsPeter Schofield, John Attia, Rodney Scott, Christopher Oldmeadow
2014Chouraki VA, Jakobsdottir J, Mather K, Adams H, Mollon J, Oldmeadow C, et al., 'A genome-wide meta-analysis of plasma clusterin levels in the charge consortium', Alzheimer's & Dementia, Washington, DC (2014) [E3]
DOI10.1016/j.jalz.2014.05.1159
Co-authorsChristopher Oldmeadow, Rodney Scott, John Attia
2014Bolton KA, Holliday EG, McEvoy M, Attia J, Proietto A, Otton G, et al., 'A HIGHLY POLYMORPHIC AG REPEAT IN THE UPSTREAM REGULATORY REGION OF THE ESTROGEN-INDUCED GENE EIG121 IS A POTENTIAL MODIFIER OF ENDOMETRIAL CANCER RISK', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Author URL
Co-authorsKelly Kiejda, Nikola Bowden, Rodney Scott, John Attia
2014Bolton KA, Holliday EG, Bowden NA, Avery-Kiejda KA, Scott RJ, 'A highly polymorphic AG repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is a modifier of disease risk in endometrial cancer', EUROPEAN JOURNAL OF CANCER (2014) [E3]
Author URL
Co-authorsRodney Scott, Nikola Bowden, Kelly Kiejda
2014Bolton KA, Holliday EG, McEvoy M, Attia J, Proietto A, Otton G, et al., 'A highly polymorphic AG repeat in the upstream regulatory region of the estrogen gene EIG121 is a potential modifier of endometrial cancer risk.', Asia-Pacific Journal of Clinical Oncology, Newcastle, NSW, Australia (2014) [E3]
DOI10.1111/ajco.12335
Co-authorsNikola Bowden, John Attia, Rodney Scott, Kelly Kiejda
2013Bolton KA, Ross J, Grice DM, Avery-Kiejda KA, Bowden NA, Holliday EG, Scott RJ, 'Role of Short Tandem Repeats in Disease and Evolutionary Mechanisms.', 34th Lorne Genome Conference Proceedings, Lorne, VIC, Australia (2013) [E3]
Co-authorsKelly Kiejda, Rodney Scott, Nikola Bowden
2013Bolton KA, Avery-Kiejda KA, Grice DM, Holliday EG, Bowden NA, Ross J, Scott RJ, 'STaRRRT: Our new resource for identifying candidates of genetic risk in breast and endometrial cancer.', Translational Cancer Research Conference Abstract booklet, Newcastle, Australia (2013) [E3]
Co-authorsKelly Kiejda, Rodney Scott, Nikola Bowden
2013Thomas J, Parsons O, Traylor M, Li L, Bevan S, Sudlow C, et al., 'The impact of CCS and TOAST classification systems on genetic associations with ischaemic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Author URL
Co-authorsJohn Attia, Chris Levi
2013Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Meta-Analysis of GWA Studies Identifies New Endometriosis Risk Loci', REPRODUCTIVE SCIENCES, Orlando, FL (2013) [E3]
Author URL
Co-authorsRodney Scott, John Attia
2012Bolton KA, Ross J, Grice DM, Kiejda KA, Bowden NA, Holliday EG, Scott R, 'Potential role of short tandem repeats in disease processes', Abstracts. 6th Australian Health & Medical Research Congress, Adelaide, SA (2012) [E3]
Co-authorsKelly Kiejda, Rodney Scott, Nikola Bowden
2012Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'A genome-wide CNV association study of Australian HNPCC/Lynch syndrome patients', Proceedings of the Australian Health & Medical Research Congress 2012, Adelaide, SA (2012) [E3]
Co-authorsJohn Attia, Rodney Scott, Bente Talseth-Palmer
2011Maguire JM, Holliday EG, Sturm J, Golledge J, Lewis M, Koblar S, et al., 'Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsJohn Attia, Rodney Scott, Chris Levi, Pablo Moscato, Mark Parsons, Lisa Lincz, Jane Maguire
2010Talseth-Palmer B, Holliday EG, Evans T-J, McPhillips M, Groombridge C, Spigelman AD, Scott R, 'Modifier genes influencing breast cancer incidence in HNPCC/Lynch syndrome', AMATA 2010 Conference: Conference Handbook, Hobart, Tasmania (2010) [E3]
Co-authorsRodney Scott, Bente Talseth-Palmer
2010Talseth-Palmer B, Holliday EG, Evans T-J, McPhillips M, McEvoy MA, Attia JR, Scott R, 'A modern approach to the search for modifying genetic loci infleuncing the high breast cancer incidence seen in an Australian HNPCC/Lynch Syndrome cohort', Proceedings of the Australian Health and Medical Research Congress 2010, Melbourne, Vic (2010) [E3]
Co-authorsJohn Attia, Bente Talseth-Palmer, Rodney Scott
Show 13 more conferences
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Grants and Funding

Summary

Number of grants18
Total funding$2,553,580

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,031,671

Helping stroke physicians choose who to thrombolyse - the "Targeting Optimal Thrombolysis Outcomes" (TOTO) study$1,031,671

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Liz Holliday, Professor John Attia, Associate Professor Vincent Thijs, Dr Simon Koblar, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jane Maguire, Doctor Lisa Lincz
SchemeProject Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400237
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20143 grants / $565,000

A comprehensive research program designed to identify genetic causes and associated biological processes underlying ischaemic stroke$520,000

Funding body: National Heart Foundation of Australia

Funding bodyNational Heart Foundation of Australia
Project TeamDoctor Liz Holliday
SchemeFuture Leader Fellowship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300632
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Biological characterisation of genetic associations for large artery atherosclerotic stroke$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Liz Holliday, Professor Rodney Scott, Conjoint Professor Chris Levi, Professor John Attia, Associate Professor Jane Maguire
SchemeStroke Research Project Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301340
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Dietary iron during pregnancy: finding the right balance$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Alexis Hure, Doctor Amanda Patterson, Doctor Liz Holliday, Associate Professor Deb Loxton, Dr Amina Khambalia
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401399
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20135 grants / $152,700

A genome wide association study on childhood brain tumours$110,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Rodney Scott, Doctor Frank Alvaro, Miss Tiffany Evans, Professor John Attia, Doctor Liz Holliday, Dr Elizabeth Milne, Professor Bruce Armstrong
SchemeResearch Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1301149
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

A pharmacogenomic study of intracerebral bleeding complicating the use of tissue plasminogen activator for acute ischaemic stroke$12,700

Funding Body: John Hunter Hospital Charitable Trust Fund Funding Scheme: Research Grant Description: Pharmacogenomics of thrombolysis in acute ischaemic stroke

Funding bodyUnknown
Project Team
SchemeUnknown
RoleLead
Funding Start2013
Funding Finish2014
GNo
Type Of FundingInternal
CategoryINTE
UONY

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
SchemeNear Miss Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300475
Type Of FundingInternal
CategoryINTE
UONY

Discovery and validation of genetic associations with ischaemic stroke$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Liz Holliday
SchemeEarly Career Researcher Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300602
Type Of FundingInternal
CategoryINTE
UONY

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
SchemeNear Miss
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300704
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20123 grants / $240,209

Interplay of genetic and environmental factors on age-related cataract development$210,209

Funding Body: NHMRC (National Health & Medical Research Council) Funding Scheme: Project Grant Description: Epidemiology of age-related cataract

Funding bodyUnknown
Project Team
SchemeUnknown
RoleInvestigator
Funding Start2012
Funding Finish2014
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Doctor Lisa Lincz
SchemeNear Miss Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200675
Type Of FundingInternal
CategoryINTE
UONY

Revealing cancer complexity - identification of Lynch syndrome cases$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Bente Talseth-Palmer, Professor Rodney Scott, Doctor Liz Holliday
SchemeEarly Career Researcher Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200519
Type Of FundingInternal
CategoryINTE
UONY

20111 grants / $4,000

HMRI Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Liz Holliday
SchemePULSE Education Prize
RoleLead
Funding Start2011
Funding Finish2011
GNoG1101187
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

20102 grants / $325,000

Integrating genome-wide association, gene expression and DNA sequence data to identify risk variants for complex disease$285,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Liz Holliday
SchemeEarly Career Fellowships
RoleLead
Funding Start2010
Funding Finish2010
GNoG0190305
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Equipment Grant$40,000

Funding Body: NHMRC (National Health & Medical Research Council) Funding Scheme: Equipment Grant Description: Equipment grant to establish high performance computing for genetic research

Funding bodyUnknown
Project Team
SchemeUnknown
RoleLead
Funding Start2010
Funding Finish2010
GNo
Type Of FundingInternal
CategoryINTE
UONY

20091 grants / $160,000

Gladys M. Brawn Memorial Postdoctoral Fellowship$160,000

Funding Body: University of Newcastle Funding Scheme: Research Fellowship Description: Postdoctoral fellowship

Funding bodyUnknown
Project Team
SchemeUnknown
RoleLead
Funding Start2009
Funding Finish2010
GNo
Type Of FundingInternal
CategoryINTE
UONY

20051 grants / $45,000

NHMRC Public Health Postgraduate Scholarship$45,000

Funding Body: NHMRC (National Health & Medical Research Council) Funding Scheme: Scholarships - Public Health Postgraduate Research Description: PhD scholarship

Funding bodyUnknown
Project Team
SchemeUnknown
RoleLead
Funding Start2005
Funding Finish2007
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20041 grants / $30,000

University of Queensland Postgraduate Scholarship$30,000

Funding Body: University of Queensland Funding Scheme: Research Scholarship Description: PhD scholarship
Funding body: University of Queensland

Funding bodyUniversity of Queensland
Project Team
SchemeResearch Scholarship
RoleLead
Funding Start2004
Funding Finish2005
GNo
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2012Genetic and Non-Genetic Studies of Type 2 Diabetes in Three Susceptible Asian Populations: Malay, Chinese and Indian
Health, Faculty of Health and Medicine
Principal Supervisor
2010Role of Tandem Repeats in Genetic Susceptibility to Breast Cancer
Health, Faculty of Health and Medicine
Co-Supervisor
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News

sleep

sleep linked to diabetes

December 12, 2013

Getting less than six hours sleep each night (compared to seven hours) may increase type 2 diabetes risk by 30 per cent but has less impact on heart disease than previously thought, researchers from the University of Newcastle have found.

Liz Holliday

Heart Foundation Fellowship

November 21, 2013

HMRI genetic statistician Dr Elizabeth Holliday has received a prestigious leadership fellowship from the Australian Heart Foundation to expand her international research work in determining the genetic causes of ischaemic stroke.

HMRI

New study shows genetic role in education

May 31, 2013

A multinational consortium of medical researchers and social scientists has found a link between educational attainment and tiny variations in a person's genetic sequence.

Dr Liz Holliday

Position

Conjoint Associate Professor
Clinical Research Design, IT and Statistical Support Unit
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Emailliz.holliday@newcastle.edu.au
Phone(02) 4042 0508
Fax(02) 4042 0039

Office

RoomCReDITSS - HMRI
BuildingHunter Medical Research Institute
LocationJohn Hunter Hospital

,
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