2021 |
Huang RC, Melton PE, Burton MA, Beilin LJ, Clarke-Harris R, Cook E, et al., 'Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors.', Epigenetics, 1-18 (2021)
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2021 |
Robinson M, Carter KW, Pennell CE, Jacoby P, Moore HC, Zubrick SR, Burgner D, 'Maternal prenatal stress exposure and sex-specific risk of severe infection in offspring.', PLoS One, 16 e0245747 (2021)
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2021 |
Crawford AA, Bankier S, Altmaier E, Barnes CLK, Clark DW, Ermel R, et al., 'Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.', J Hum Genet, (2021)
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2021 |
McLaughlin C, Schutze R, Henley D, Pennell C, Straker L, Smith A, 'Prenatal and childhood stress exposure and the sex specific response to psychosocial stress in adulthood', Psychoneuroendocrinology, 125 (2021)
© 2020 Elsevier Ltd Background: Early life stress exposures may cause dysregulation of the Hypothalamic Pituitary Adrenal (HPA)-axis and cortisol production, with timing and sex-s... [more]
© 2020 Elsevier Ltd Background: Early life stress exposures may cause dysregulation of the Hypothalamic Pituitary Adrenal (HPA)-axis and cortisol production, with timing and sex-specific effects. Studies examining the impact of early life stress on cortisol responses to stress have focused on severe trauma and have produced inconsistent results. The aim of this study was to investigate whether common early life stressors, experienced prenatally or throughout childhood and adolescence, play a role in the dysregulation of the HPA-axis in early adulthood. Methods: Exposures to common life stress events were examined prenatally and as longitudinal trajectories of stress exposure from birth to age 17 in males and females from Gen2 of the Raine Study. At age 18 years, 986 participants were assessed for their salivary cortisol response to a psychosocial stressor - the Trier Social Stress Test (TSST). Results: In males there was an association between high prenatal stress exposure at 18 weeks gestation and a heightened TSST response. We found evidence for sex-specific associations with increasing stress exposure during adolescence (the ascending trajectory) whereby males were more likely to be non-responders to the TSST and females were more likely to be responders. Conclusion: Our results point to sex differences in how stress exposure in-utero and exposure increasing during adolescence may affect regulation of the HPA-axis later in life. However, overall common life stress events experienced in-utero, during childhood and adolescence show limited impact on the HPA-axis stress response in early adulthood.
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2020 |
Pennell C, Chen SQ, Kluckow H, Wisely K, Walker B, 'Live streamed ward rounds a tool for clinical teaching during the COVID - 19 pandemic', MEDICAL JOURNAL OF AUSTRALIA, (2020)
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2020 |
Mozooni M, Pennell CE, Preen DB, 'Healthcare factors associated with the risk of antepartum and intrapartum stillbirth in migrants in Western Australia (2005-2013): A retrospective cohort study', PLoS medicine, 17 (2020) [C1]
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2020 |
Eastwood PR, Ward S, Bucks RS, Maddison K, Smith A, Huang R, et al., 'THE PREVALENCE OF COMMON SLEEP DISORDERS IN YOUNG ADULTS: A POPULATION-BASED STUDY', SLEEP, 43 1-11 (2020) [C1]
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2020 |
Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, et al., 'Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits', PLoS Genetics, 16 (2020)
© 2020 Public Library of Science. All rights reserved. The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood ... [more]
© 2020 Public Library of Science. All rights reserved. The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
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2020 |
Hollis JL, Doherty E, Dray J, Tremain D, Hunter M, Takats K, et al., 'Are antenatal interventions effective in improving multiple health behaviours among pregnant women? A systematic review protocol.', Syst Rev, 9 204 (2020)
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2020 |
Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, et al., 'Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.', Diabetes, 69 2806-2818 (2020)
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2020 |
Mozooni M, Preen DB, Pennell CE, 'The influence of acculturation on the risk of stillbirth in migrant women residing in Western Australia', PLOS ONE, 15 (2020) [C1]
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2020 |
Fan Q, Pozarickij A, Tan NYQ, Guo X, Verhoeven VJM, Vitart V, et al., 'Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error', COMMUNICATIONS BIOLOGY, 3 (2020)
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2020 |
Henriksen LS, Mathiesen BK, Assens M, Krause M, Skakkebæk NE, Juul A, et al., 'Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates.', Environ Res, 184 109231 (2020) [C1]
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2020 |
Zheng Y, Huang T, Wang T, Mei Z, Sun Z, Zhang T, et al., 'Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood', EUROPEAN JOURNAL OF EPIDEMIOLOGY, 35 685-697 (2020)
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2020 |
Martin WN, Pennell CE, Wang CA, Reynolds R, 'Developmental programming and the hypothalamic pituitary adrenal axis', Current Opinion in Endocrine and Metabolic Research, 13 13-19 (2020)
© 2020 Elsevier Ltd Humans, similar to many other species, exhibit developmental plasticity ¿ the ability to modify the structure and function of key vital organs during specific ... [more]
© 2020 Elsevier Ltd Humans, similar to many other species, exhibit developmental plasticity ¿ the ability to modify the structure and function of key vital organs during specific developmental windows. Adverse exposures during these critical periods may alter organ function to enhance survival; however, over many years ¿ these alterations may predispose toward chronic disease. The hypothalamic¿pituitary¿adrenal axis plays an important role in maintaining metabolic homoeostasis and coordinating the neuropsychiatric response to stress. Decades of animal and human research suggests that the long-term function of this axis may be particularly sensitive to adverse exposures during critical developmental windows. The aim of this review is to summarise the existing knowledge of hypothalamic¿pituitary¿adrenal axis programming in humans and briefly discuss its implications for long-term health.
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2020 |
Lee SS-Y, Sanfilippo PG, Yazar S, Pennell CE, Hewitt AW, Wang CA, et al., 'Do Levels of Stress Markers Influence the Retinal Nerve Fiber Layer Thickness in Young Adults?', Journal of glaucoma, 29 587-592 (2020) [C1]
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2020 |
Rauschert S, Melton PE, Heiskala A, Karhunen V, Burdge G, Craig JM, et al., 'Machine learning-based dna methylation score for fetal exposure to maternal smoking: Development and validation in samples collected from adolescents and adults', Environmental Health Perspectives, 128 1-11 (2020) [C1]
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2020 |
Thyssen JP, Ahluwalia TS, Paternoster L, Ballardini N, Bergström A, Melén E, et al., 'Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis', Allergy: European Journal of Allergy and Clinical Immunology, 75 1481-1485 (2020) [C1]
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2019 |
Huang T, Sun D, Heianza Y, Bergholdt HKM, Gao M, Fang Z, et al., 'Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies', Clinical Chemistry, 65 751-760 (2019) [C1]
© 2019 American Association for Clinical Chemistry. BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed... [more]
© 2019 American Association for Clinical Chemistry. BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined. METHODS: We performed Mendelian randomization analysis using an established genetic variant located upstream of the lactase gene (LCT-13910 C/T, rs4988235) associated with dairy intake as an instrumental variable (IV). The causal effects of dairy intake on body composition and cardiometabolic traits (lipids, glycemic traits, and inflammatory factors) were quantified by IV estimators among 182041 participants from 18 studies. RESULTS: Each 1 serving/day higher dairy intake was associated with higher lean mass [ß (SE) = 0.117 kg (0.035); P = 0.001], higher hemoglobin A1c [0.009% (0.002); P < 0.001], lower LDL [-0.014 mmol/L (0.006); P = 0.013], total cholesterol (TC) [-0.012 mmol/L (0.005); P = 0.023], and non-HDL [-0.012 mmol/L (0.005); P = 0.028]. The LCT-13910 C/T CT + TT genotype was associated with 0.214 more dairy servings/day (SE = 0.047; P < 0.001), 0.284 cm higher waist circumference (SE = 0.118; P = 0.017), 0.112 kg higher lean mass (SE = 0.027; P = 3.8 × 10-5), 0.032 mmol/L lower LDL (SE = 0.009; P = 0.001), and 0.032 mmol/L lower TC (SE = 0.010; P = 0.001). Genetically higher dairy intake was associated with increased lean mass [0.523 kg per serving/day (0.170); P = 0.002] after correction for multiple testing (0.05/18). However, we find that genetically higher dairy intake was not associated with lipids and glycemic traits. CONCLUSIONS: The present study provides evidence to support a potential causal effect of higher dairy intake on increased lean mass among adults. Our findings suggest that the observational associations of dairy intake with lipids and glycemic traits may be the result of confounding.
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2019 |
Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, et al., 'Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology', American Journal of Human Genetics, 105 15-28 (2019) [C1]
© 2019 American Society of Human Genetics Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable.... [more]
© 2019 American Society of Human Genetics Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p < 2 × 10-7). Comparison of exome array variants to regional linkage disequilibrium (LD) patterns and prior genome-wide association study (GWAS) results detected candidate variants (r2 > .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p < 1 × 10-4) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.
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2019 |
White SW, Cheng JC, Penova-Veselinovic B, Wang C, White M, Ingleby B, et al., 'Single dose v two-dose antenatal anti-D prophylaxis: a randomised controlled trial', Medical Journal of Australia, 211 261-265 (2019) [C1]
© 2019 AMPCo Pty Ltd Objective: To compare rates of detectability of circulating Rh(D)-immunoglobulin (anti-D) at delivery with single and two-dose antenatal anti-D prophylaxis (R... [more]
© 2019 AMPCo Pty Ltd Objective: To compare rates of detectability of circulating Rh(D)-immunoglobulin (anti-D) at delivery with single and two-dose antenatal anti-D prophylaxis (RAADP) regimens; to compare compliance with the two regimens. Design: Open label, randomised controlled trial between May 2013 and November 2015. Setting, participants: 277 women who attended a tertiary obstetric referral hospital in Perth for antenatal care and were at least 18 years of age, less than 30 weeks pregnant and yet to receive RAADP, Rh(D)-negative (negative antibody screen), and who intended to deliver their baby at the hospital. Exclusion criteria were prior anti-D sensitisation, any contraindication of anti-D administration, and a history of isolated IgA deficiency. Interventions: One 1500¿IU anti-D dose at 28 weeks of pregnancy (single dose regimen); two doses of 625¿IU each at 28 and 34 weeks of pregnancy (two-dose regimen). Main outcome measures: The primary outcome was the proportion of women with detectable anti-D levels at delivery; the secondary outcome was compliance with the allocated RAADP regimen. Results: Circulating anti-D was detectable at delivery in a greater proportion of women in the two-dose group (111 of 129, 86%) than in the single dose group (70 of 125, 56%; P¿<¿0.001). Compliance was not significantly different between the single dose (86 of 138, 61%) and two-dose groups (70 of 139, 50%; P¿=¿0.06). Conclusions: The two-dose RAADP schedule currently recommended in Australia provides better protection against Rh(D) sensitisation than a one-dose regimen. Trial registration: Australian and New Zealand Clinical Trials Registry (ACTRN12613000661774).
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2019 |
Alves AC, De Silva NMG, Karhunen V, Sovio U, Das S, Taal HR, et al., 'GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI', SCIENCE ADVANCES, 5 (2019)
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2019 |
Rauschert S, Melton PE, Burdge G, Craig J, Godfrey KM, Holbrook JD, et al., 'Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated with cardiometabolic risk', Frontiers in Genetics, 10 (2019) [C1]
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2019 |
Huang RC, Lillycrop KA, Beilin LJ, Godfrey KM, Anderson D, Mori TA, et al., 'Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular disease.', The Journal of clinical endocrinology and metabolism, 104 3012-3024 (2019) [C1]
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2019 |
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, et al., 'Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution', Nature Genetics, 51 452-469 (2019) [C1]
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed ... [more]
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF =5%) and nine low-frequency or rare (MAF <5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
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2019 |
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, et al., 'Associations of autozygosity with a broad range of human phenotypes', NATURE COMMUNICATIONS, 10 (2019) [C1]
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2019 |
Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, et al., 'Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration', Nature Communications, 10 1-13 (2019) [C1]
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2019 |
Hartwig FP, Davies NM, Horta BL, Ahluwalia TS, Bisgaard H, Bonnelykke K, et al., 'Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 48 45-57 (2019)
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2019 |
Middeldorp CM, Mahajan A, Horikoshi M, Robertson NR, Beaumont RN, Bradfield JP, et al., 'The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects', EUROPEAN JOURNAL OF EPIDEMIOLOGY, 34 279-300 (2019) [C1]
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2019 |
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, et al., 'Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors', Nature Genetics, 51 804-814 (2019) [C1]
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has... [more]
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight¿blood pressure association is attributable to genetic effects, and not to intrauterine programming.
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2019 |
Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, et al., 'Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium', MOLECULAR PSYCHIATRY, 24 1920-1932 (2019)
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2019 |
Haworth S, Shapland CY, Hayward C, Prins BP, Felix JF, Medina-Gomez C, et al., 'Low-frequency variation in TP53 has large effects on head circumference and intracranial volume', NATURE COMMUNICATIONS, 10 (2019) [C1]
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2019 |
Zhu K, Oddy WH, Holt P, Ping-Delfos WCS, McVeigh J, Straker L, et al., 'Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults', JOURNAL OF THE ENDOCRINE SOCIETY, 3 563-576 (2019)
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2019 |
Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, et al., 'Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology (vol 105, pg 15, 2019)', AMERICAN JOURNAL OF HUMAN GENETICS, 105 670-671 (2019)
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2019 |
Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, et al., 'A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity', Human Molecular Genetics, 28 3327-3338 (2019) [C1]
© 2019 The Author(s) 2019. Published by Oxford University Press. All rights reserved. Although hundreds of genome-wide association studies-implicated loci have been reported for a... [more]
© 2019 The Author(s) 2019. Published by Oxford University Press. All rights reserved. Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13 005 cases (=95th percentile of body mass index (BMI) achieved 2-18 years old) and 15 599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1888 cases and 4689 controls from seven cohorts of European and North/South American ancestry. In addition to observing 18 previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene, METTL15). The variant was nominally associated with only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than 10 single nucleotide polymorphisms (SNPs) (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.
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2018 |
Huang T, Ding M, Bergholdt HKM, Wang T, Heianza Y, Sun D-J, et al., 'Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies', CLINICAL CHEMISTRY, 64 183-191 (2018)
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2018 |
Guastella AJ, Cooper MN, White CRH, White MK, Pennell CE, Whitehouse AJO, 'Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age?', JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 59 1323-1332 (2018)
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2018 |
Pels A, Mol BWJ, Singer J, Lee T, Von Dadelszen P, Ganzevoort W, et al., 'Influence of gestational age at initiation of antihypertensive therapy: Secondary analysis of CHIPS trial data (control of hypertension in pregnancy study)', Hypertension, 71 1170-1177 (2018)
© 2018 The Authors. For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, whi... [more]
© 2018 The Authors. For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, while minimizing any potentially negative effect on fetal growth, by delaying initiation of antihypertensive therapy until later in pregnancy. For the 981 women with nonsevere, chronic or gestational hypertension randomized to less-tight (target diastolic blood pressure, 100 mm Hg), or tight (target, 85 mm Hg) control, we used mixed-effects logistic regression to examine whether the effect of less-tight (versus tight) control on major outcomes was dependent on gestational age at randomization, adjusting for baseline factors as in the primary analysis and including an interaction term between gestational age at randomization and treatment allocation. Gestational age was considered categorically (quartiles) and continuously (linear or quadratic form), and the optimal functional form selected to provide the best fit to the data based on the Akaike information criterion. Randomization before (but not after) 24 weeks to less-tight (versus tight) control was associated with fewer babies with birth weight <10th centile (Pinteraction=0.005), but more preterm birth (Pinteraction=0.043), and no effect on perinatal death or high-level neonatal care >48 hours (Pinteraction=0.354). For the mother, less-tight (versus tight) control was associated with more severe hypertension at all gestational ages but particularly so before 28 weeks (Pinteraction=0.076). In women with nonsevere, chronic, or gestational hypertension, there seems to be no gestational age at which less-tight (versus tight) control is the preferred management strategy to optimize maternal or perinatal outcomes.
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2018 |
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, et al., 'Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity', NATURE GENETICS, 50 26-+ (2018)
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2018 |
Ayonrinde OT, Adams LA, Mori TA, Beilin LJ, de Klerk N, Pennell CE, et al., 'Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents', HEPATOLOGY, 67 108-122 (2018)
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2018 |
Ali SB, Jeelall Y, Pennell CE, Hart R, McLean-Tooke A, Lucas M, 'The role of immunological testing and intervention in reproductive medicine: A fertile collaboration?', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 79 (2018)
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2018 |
Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmueller J, Ang W, et al., 'Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks', NATURE GENETICS, 50 42-+ (2018)
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2018 |
Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, et al., 'Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent', MOLECULAR NUTRITION & FOOD RESEARCH, 62 (2018)
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2018 |
Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, et al., 'Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders', American Journal of Human Genetics, 103 691-706 (2018) [C1]
© 2018 American Society of Human Genetics C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The... [more]
© 2018 American Society of Human Genetics C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5 × 10-8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.
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2018 |
Mozooni M, Preen DB, Pennell CE, 'Stillbirth in Western Australia, 2005-2013: the influence of maternal migration and ethnic origin', The Medical journal of Australia, 209 394-400 (2018) [C1]
OBJECTIVE: To investigate prevalence rates and the risk of ante- and intrapartum stillbirth in Western Australia with respect to maternal country of birth and ethnic origin. DESIG... [more]
OBJECTIVE: To investigate prevalence rates and the risk of ante- and intrapartum stillbirth in Western Australia with respect to maternal country of birth and ethnic origin. DESIGN, SETTING AND PARTICIPANTS: Whole population retrospective cohort analysis of de-identified, linked routinely collected birth, perinatal and mortality data for all births to non-Indigenous women in WA during 2005-2013. MAIN OUTCOME MEASURES: Crude and adjusted odds ratios (aORs) with 95% confidence intervals were estimated by logistic regression and adjusted for confounding factors, for all stillbirths, antepartum stillbirths and intrapartum stillbirths, stratified by migrant status and ethnic background (white, Asian, Indian, African, Maori, other). RESULTS: Women born overseas were more likely to have a stillbirth than Australian-born women (aOR, 1.26; 95% CI, 1.09-1.37). There was no significant difference for any type of stillbirth between Australian-born women of white and non-white backgrounds, but non-white migrant women were more likely than white migrants to have a stillbirth (OR, 1.42; 95% CI, 1.19-1.70). Compared with Australian-born women, migrants of Indian (aOR, 1.71; 95% CI, 1.17-2.47), African (aOR, 2.12; 95% CI, 1.46-3.08), and "other" ethnic origins (aOR, 1.43; 95% CI, 1.06-1.93) were more likely to have antepartum stillbirths; women of African (aOR, 5.08; 95% CI, 3.14-8.22) and "other" (aOR, 1.86; 95% CI, 1.15-3.00) background were more likely to have an intrapartum stillbirth. CONCLUSIONS: Immigrants of African or Indian background appear to be at greater risk of ante- and intrapartum stillbirth in WA. Specific strategies are needed reduce the prevalence of stillbirth in these communities.
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2018 |
Porter MC, Pennell CE, Woods P, Dyer J, Merritt AJ, Currie BJ, 'Case Report: Chorioamnionitis and Premature Delivery due to Burkholderia pseudomallei Infection in Pregnancy', AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 98 797-799 (2018)
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2018 |
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, et al., 'Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics', HUMAN MOLECULAR GENETICS, 27 742-756 (2018)
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2018 |
Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-Gomez C, Yakimov V, et al., 'Consortium-based genome-wide meta-analysis for childhood dental caries traits', HUMAN MOLECULAR GENETICS, 27 3113-3127 (2018)
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2018 |
Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, et al., 'Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis', NATURE GENETICS, 50 1072-+ (2018)
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2018 |
Hart RJ, Doherty DA, Keelan JA, Minaee NS, Thorstensen EB, Dickinson JE, et al., 'The impact of antenatal Bisphenol A exposure on male reproductive function at 20-22 years of age', REPRODUCTIVE BIOMEDICINE ONLINE, 36 340-347 (2018)
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2018 |
Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minaee NS, et al., 'The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age', FRONTIERS IN ENDOCRINOLOGY, 9 (2018)
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2018 |
Blanken LME, Dass A, Alvares G, van der Ende J, Schoemaker NK, El Marroun H, et al., 'A prospective study of fetal head growth, autistic traits and autism spectrum disorder', AUTISM RESEARCH, 11 602-612 (2018)
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2018 |
Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, et al., 'Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects', AMERICAN JOURNAL OF HUMAN GENETICS, 102 88-102 (2018)
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2018 |
McKeown NM, Dashti HS, Ma J, Haslam DE, Kiefte-de Jong JC, Smith CE, et al., 'Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis', DIABETOLOGIA, 61 317-330 (2018)
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2018 |
Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, et al., 'Maternal and fetal genetic contribution to gestational weight gain', INTERNATIONAL JOURNAL OF OBESITY, 42 775-784 (2018)
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2018 |
Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, et al., 'Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (vol 50, pg 1072, 2018)', NATURE GENETICS, 50 1343-1343 (2018)
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2018 |
Warrington NM, Shevroja E, Hemani G, Hysi PG, Jiang Y, Auton A, et al., 'Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero', Human Molecular Genetics, 27 2025-2038 (2018) [C1]
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorph... [more]
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorphic and is commonly used as a non-invasive biomarker of prenatal androgen exposure. Most association studies of 2D:4D ratio with a diverse range of sexspecific traits have typically involved small sample sizes and have been difficult to replicate, raising questions around the utility and precise meaning of the measure. In the largest genome-wide association meta-analysis of 2D:4D ratio to date (N=15 661, with replication N=75 821), we identified 11 loci (9 novel) explaining 3.8% of the variance in mean 2D:4D ratio. We also found weak evidence for association (b=0.06; P=0.02) between 2D:4D ratio and sensitivity to testosterone [length of the CAG microsatellite repeat in the androgen receptor (AR) gene] in females only. Furthermore, genetic variants associated with (adult) testosterone levels and/or sex hormone-binding globulin were not associated with 2D:4D ratio in our sample. Although we were unable to find strong evidence from our genetic study to support the hypothesis that 2D:4D ratio is a direct biomarker of prenatal exposure to androgens in healthy individuals, our findings do not explicitly exclude this possibility, and pathways involving testosterone may become apparent as the size of the discovery sample increases further. Our findings provide new insight into the underlying biology shaping 2D:4D variation in the general population.
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2017 |
Ding M, Huang T, Bergholdt HKM, Nordestgaard BG, Ellervik C, Qi L, et al., 'Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study', BMJ-BRITISH MEDICAL JOURNAL, 356 (2017)
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2017 |
Zhu K, Allen K, Mountain J, Lye S, Pennell C, Walsh JP, 'Depressive symptoms, body composition and bone mass in young adults: A prospective cohort study', International Journal of Obesity, 41 576-581 (2017)
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background:An association between depression and obesity is well recognised, but longitudinal st... [more]
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background:An association between depression and obesity is well recognised, but longitudinal studies of depressive symptoms in adolescents as a predictor of body composition are lacking.Objective:We examined depressive symptoms at age 14, 17 and 20 years as predictors of lean, fat and bone mass at age 20 years in a birth cohort.Subjects/Methods:In 1161 participants (569 females) in the Western Australia Pregnancy Cohort (Raine) Study, depressive symptoms were assessed using the Beck Depression Inventory for Youth at age 14 and 17 years, and the Depression, Anxiety and Stress Scale 21 at age 20 years. Participants were further classified into two trajectories using latent class analysis: no/transient and persistent/recurrent depression. At age 20 years, lean body mass (LBM), fat body mass (FBM) and total body bone mass were measured by dual-energy X-ray absorptiometry.Results:In females, accounting for age and lifestyle factors, depression scores at age 14 and 20 years were positively associated with body weight, body mass index (BMI), FBM and % FBM (r=0.110-0.184, P<0.05) but negatively correlated with % LBM (r=-0.120, P<0.05) at age 20 years. Females in the persistent/recurrent depression trajectory (n=99) had significantly higher body weight (+5.1 kg), BMI (+1.8 kg m -2), FBM (+3.9 kg) and % FBM (+2.2%) and significantly lower % LBM (-2.2%) at age 20 years than those with no/transient depression (n=470; all P<0.05). In males, depression scores at age 17 and 20 years were negatively associated with LBM but not weight or BMI, and depression trajectory was not a predictor of body composition at age 20 years. Depression scores and trajectories did not predict bone mass in either males or females.Conclusions:Depressive symptoms and persistent/recurrent depression in adolescence are predictors of greater adiposity at age 20 years in females, but not males, but do not predict bone mass in either gender.
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2017 |
Rietschel L, Streit F, Zhu G, McAloney K, Frank J, Couvy-Duchesne B, et al., 'Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes', Scientific Reports, 7 (2017)
© 2017 The Author(s). Hair cortisol concentration (HCC) is a promising measure of long-Term hypothalamus-pituitary-Adrenal (HPA) axis activity. Previous research has suggested an ... [more]
© 2017 The Author(s). Hair cortisol concentration (HCC) is a promising measure of long-Term hypothalamus-pituitary-Adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.
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2017 |
Zhu K, Oddy WH, Holt P, Ping-Delfos WCS, Mountain J, Lye S, et al., 'Tracking of vitamin D status from childhood to early adulthood and its association with peak bone mass', AMERICAN JOURNAL OF CLINICAL NUTRITION, 106 276-283 (2017)
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2017 |
Kreiner E, Waage J, Standl M, Brix S, Pers TH, Alves AC, et al., 'Shared genetic variants suggest common pathways in allergy and autoimmune diseases', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140 771-781 (2017)
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2017 |
Straker L, Mountain J, Jacques A, White S, Smith A, Landau L, et al., 'Cohort Profile: The Western Australian Pregnancy Cohort (Raine) Study-Generation 2', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 46 1384-+ (2017)
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2017 |
Herbison CE, Allen K, Robinson M, Newnham J, Pennell C, 'The impact of life stress on adult depression and anxiety is dependent on gender and timing of exposure', DEVELOPMENT AND PSYCHOPATHOLOGY, 29 1443-1454 (2017)
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2017 |
Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, et al., 'Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets', NATURE GENETICS, 49 416-425 (2017)
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2017 |
White SW, Eastwood PR, Straker LM, Adams LA, Newnham JP, Lye SJ, Pennell CE, 'The Raine study had no evidence of significant perinatal selection bias after two decades of follow up: a longitudinal pregnancy cohort study', BMC PREGNANCY AND CHILDBIRTH, 17 (2017)
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2017 |
Mace A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Noukas M, et al., 'CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits', NATURE COMMUNICATIONS, 8 (2017)
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2017 |
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, et al., 'Rare and low-frequency coding variants alter human adult height', NATURE, 542 186-190 (2017)
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2016 |
Hart RJ, Doherty DA, Keelan JA, McLachlan R, Skakkebaek NE, Norman RJ, et al., 'Early Life Events Predict Adult Testicular Function; Data Derived From the Western Australian (Raine) Birth Cohort', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101 3333-3344 (2016)
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2016 |
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, et al., 'Genome-wide associations for birth weight and correlations with adult disease', NATURE, 538 248-+ (2016)
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2016 |
Henley D, Brown S, Pennell C, Lye S, Torpy DJ, 'Evidence for central hypercortisolism and elevated blood pressure in adolescent offspring of mothers with pre-eclampsia', CLINICAL ENDOCRINOLOGY, 85 583-589 (2016)
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2016 |
White CRH, Doherty DA, Cannon JW, Kohan R, Newnham JP, Pennell CE, 'Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit', JOURNAL OF PERINATAL MEDICINE, 44 573-584 (2016)
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2016 |
Le-Ha C, Herbison CE, Beilin LJ, Burrows S, Henley DE, Lye SJ, et al., 'Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents', PSYCHONEUROENDOCRINOLOGY, 66 118-124 (2016)
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2016 |
McVeigh JA, Zhu K, Mountain J, Pennell CE, Lye SJ, Walsh JP, Straker LM, 'Longitudinal Trajectories of Television Watching Across Childhood and Adolescence Predict Bone Mass at Age 20 Years in the Raine Study', JOURNAL OF BONE AND MINERAL RESEARCH, 31 2032-2040 (2016)
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2016 |
Middeldorp CM, Hammerschlag AR, Ouwens KG, Groen-Blokhuis MM, St Pourcain B, Greven CU, et al., 'A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts', JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 55 896-905 (2016)
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2016 |
Felix JF, Bradfield JP, Monnereau C, van der Valk RJP, Stergiakouli E, Chesi A, et al., 'Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index', HUMAN MOLECULAR GENETICS, 25 389-403 (2016)
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2016 |
Herbison CE, Henley D, Marsh J, Atkinson H, Newnham JP, Matthews SG, et al., 'Characterization and novel analyses of acute stress response patterns in a population-based cohort of young adults: influence of gender, smoking, and BMI', STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 19 139-150 (2016)
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2016 |
Shrine N, Tobin MD, Schurmann C, Artigas MS, Hui J, Lehtimaki T, et al., 'Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity', BMC GENETICS, 17 (2016)
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2016 |
White SW, Marsh JA, Lye SJ, Briollais L, Newnham JP, Pennell CE, 'Improving customized fetal biometry by longitudinal modelling', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 29 1888-1894 (2016)
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2016 |
Pappa I, St Pourcain B, Benke K, Cavadino A, Hakulinen C, Nivard MG, et al., 'A Genome-Wide Approach to Children's Aggressive Behavior: The EAGLE consortium', AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 171 562-572 (2016)
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2016 |
Heng YJ, Pennell CE, McDonald SW, Vinturache AE, Xu J, Lee MWF, et al., 'Maternal Whole Blood Gene Expression at 18 and 28 Weeks of Gestation Associated with Spontaneous Preterm Birth in Asymptomatic Women', PLOS ONE, 11 (2016)
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2016 |
Demmer DL, Beilin LJ, Hands B, Burrows S, Pennell CE, Lye SJ, et al., 'Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the 'Gold Standard' Tarnished?', PLOS ONE, 11 (2016)
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2016 |
Demmer DL, Beilin LJ, Hands B, Burrows S, Cox KL, Pennell CE, et al., 'Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the 'Gold Standard' Tarnished? (vol 11, e0162164, 2016)', PLOS ONE, 11 (2016)
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2016 |
Unwin LM, Maybery MT, Murphy A, Lilje W, Bellesini M, Hunt AM, et al., 'A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism', AUTISM RESEARCH, 9 210-216 (2016)
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2016 |
Parmar PG, Taal HR, Timpson NJ, Thiering E, Lehtimaki T, Marinelli M, et al., 'International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents', CIRCULATION-CARDIOVASCULAR GENETICS, 9 266-+ (2016)
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2016 |
Rath SR, Marsh JA, Newnham JP, Zhu K, Atkinson HC, Mountain J, et al., 'Parental pre-pregnancy BMI is a dominant early-life risk factor influencing BMI of offspring in adulthood', OBESITY SCIENCE & PRACTICE, 2 48-57 (2016)
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2016 |
Zhu K, Henley D, Pennell C, Herbison CE, Mountain J, Lye S, Walsh JP, 'Associations between hypothalamic-pituitary-adrenal axis function and peak bone mass at 20 years of age in a birth cohort', BONE, 85 37-44 (2016)
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2015 |
Pettigrew KA, Fajutrao Valles SF, Moll K, Northstone K, Ring S, Pennell C, et al., 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts', Genes, Brain and Behavior, 14 369-376 (2015)
© 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular lev... [more]
© 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.
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2015 |
Straker LM, Hall GL, Mountain J, Howie EK, White E, McArdle N, et al., 'Rationale, design and methods for the 22 year follow-up of the Western Australian Pregnancy Cohort (Raine) Study', BMC Public Health, 15 (2015)
© 2015 Straker et al. Background: Young adulthood is a critical life period for health and health behaviours. Related measurements collected before and after birth, and during chi... [more]
© 2015 Straker et al. Background: Young adulthood is a critical life period for health and health behaviours. Related measurements collected before and after birth, and during childhood and adolescence can provide a life-course analysis of important factors that contribute to health and behaviour in young adulthood. The Western Australian Pregnancy Cohort (Raine) Study has collected a large number of such measurements during the fetal, perinatal, infancy, childhood and adolescence periods and plans to relate them to common health issues and behaviours in young adults, including spinal pain, asthma, sleep disorders, physical activity and sedentary behaviour and, work absenteeism and presenteeism. The aim of this paper is to describe the rationale, design and methods of the 22 year follow-up of the Raine Study cohort. Methods/Design: The Raine Study is a prospective cohort study. Participants still active in the cohort (n = 2,086) were contacted around the time of their 22nd birthday and invited to participate in the 22 year follow-up. Each was asked to complete a questionnaire, attend a research facility for physical assessment and an overnight sleep study, wear activity monitors for a week, and to maintain a sleep and activity diary over this week. The questionnaire was broad and included questions related to sociodemographics, medical history, quality of life, psychological factors, lifestyle factors, spinal pain, respiratory, sleep, activity and work factors. Physical assessments included anthropometry, blood pressure, back muscle endurance, tissue sensitivity, lung function, airway reactivity, allergic status, 3D facial photographs, cognitive function, and overnight polysomnography. Discussion: Describing the prevalence of these health issues and behaviours in young adulthood will enable better recognition of the issues and planning of health care resources. Providing a detailed description of the phenotype of these issues will provide valuable information to help educate health professionals of the needs of young adults. Understanding the life-course risk factors of health issues and behaviours in young adulthood will have important health planning implications, supporting the development of targeted interventions to improve current health status and reduce the onset and development of further ill-health across adulthood.
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2015 |
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, et al., 'Corrigendum: Rare coding variants and X-linked loci associated with age at menarche', Nature Communications, 6 (2015)
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2015 |
Penova-Veselinovic B, Keelan JA, Wang CA, Newnham JP, Pennell CE, 'Changes in inflammatory mediators in gingival crevicular fluid following periodontal disease treatment in pregnancy: relationship to adverse pregnancy outcome', JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112 1-10 (2015)
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2015 |
Warrington NM, Howe LD, Paternoster L, Kaakinen M, Herrala S, Huikari V, et al., 'A genome-wide association study of body mass index across early life and childhood', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 44 700-712 (2015)
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2015 |
van der Valk RJP, Kreiner-Moller E, Kooijman MN, Guxens M, Stergiakouli E, Saaf A, et al., 'A novel common variant in DCST2 is associated with length in early life and height in adulthood', HUMAN MOLECULAR GENETICS, 24 1155-1168 (2015)
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2015 |
Springelkamp H, Iglesias AI, Cuellar-Partida G, Amin N, Burdon KP, van Leeuwen EM, et al., 'ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure', HUMAN MOLECULAR GENETICS, 24 2689-2699 (2015)
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2015 |
Robinson M, Pennell CE, McLean NJ, Tearne JE, Oddy WH, Newnham JP, 'Risk Perception in Pregnancy lContext, Consequences, and Clinical Implications', EUROPEAN PSYCHOLOGIST, 20 120-127 (2015)
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2015 |
Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP, et al., 'Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis', NATURE GENETICS, 47 1449-+ (2015)
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2015 |
McKnight CM, Sherwin JC, Yazar S, Forward H, Tan AX, Hewitt AW, et al., 'Pterygium and conjunctival ultraviolet autofluorescence in young Australian adults: the Raine study', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 43 300-307 (2015)
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2015 |
Anderson D, Fakiola M, Hales BJ, Pennell CE, Thomas WR, Blackwell JM, 'Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniae', GENES AND IMMUNITY, 16 289-296 (2015)
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2015 |
Christiaens I, Ang QW, Gordon LN, Fang X, Williams SM, Pennell CE, Olson DM, 'Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth', BMC MEDICAL GENETICS, 16 (2015)
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2015 |
Paananen M, O'Sullivan P, Straker L, Beales D, Coenen P, Karppinen J, et al., 'A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: a longitudinal cohort study', ARTHRITIS RESEARCH & THERAPY, 17 (2015)
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2015 |
Heng YJ, Taylor L, Larsen BG, Chua HN, Pung SM, Lee MWF, et al., 'Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor', JOURNAL OF PROTEOME RESEARCH, 14 457-466 (2015)
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2015 |
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, et al., 'Rare coding variants and X-linked loci associated with age at menarche', NATURE COMMUNICATIONS, 6 (2015)
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2015 |
Marenholz I, Esparza-Gordillo J, Rueschendorf F, Bauerfeind A, Strachan DP, Spycher BD, et al., 'Meta-analysis identifies seven susceptibility loci involved in the atopic march', NATURE COMMUNICATIONS, 6 (2015)
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2015 |
Yazar S, Cuellar-Partida G, McKnight CM, Quach-Thanissorn P, Mountain JA, Coroneo MT, et al., 'Genetic and Environmental Factors in Conjunctival UV Autofluorescence', JAMA OPHTHALMOLOGY, 133 406-412 (2015)
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2015 |
Cuellar-Partida G, Springelkamp H, Lucas SEM, Yazar S, Hewitt AW, Iglesias AI, et al., 'WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness', HUMAN MOLECULAR GENETICS, 24 5060-5068 (2015)
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2014 |
Hysi PG, Cheng C-Y, Springelkamp H, Macgregor S, Bailey JNC, Wojciechowski R, et al., 'Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma', NATURE GENETICS, 46 1126-1130 (2014)
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2014 |
Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, et al., 'Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche', NATURE, 514 92-+ (2014)
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2014 |
Zhu K, Briffa K, Smith A, Mountain J, Briggs AM, Lye S, et al., 'Gender differences in the relationships between lean body mass, fat mass and peak bone mass in young adults', Osteoporosis International, 25 1563-1570 (2014)
Summary: The relationships between fat mass and bone mass in young adults are unclear. In 1,183 young Australians, lean body mass had a strong positive relationship with total bod... [more]
Summary: The relationships between fat mass and bone mass in young adults are unclear. In 1,183 young Australians, lean body mass had a strong positive relationship with total body bone mass in both genders. Fat mass was a positive predictor of total body bone mass in females, with weaker association in males. Introduction: Body weight and lean body mass are established as major determinants of bone mass, but the relationships between fat mass (including visceral fat) and peak bone mass in young adults are unclear. The aim of this study was to evaluate the associations between bone mass in young adults and three body composition measurements: lean body mass, fat mass and trunk-to-limb fat mass ratio (a surrogate measure of visceral fat). Methods: Study participants were 574 women and 609 men aged 19-22 years from the Raine study. Body composition, total body bone mineral content (TBBMC), bone area and areal bone mineral density (TBBMD) were measured using DXA. Results: In multivariate linear regression models with height, lean body mass, fat mass and trunk-to-limb fat mass ratio as predictor variables, lean mass was uniquely associated with the largest proportion of variance of TBBMC and TBBMD in males (semi-partial R 2 0.275 and 0.345, respectively) and TBBMC in females (semi-partial R 2 0.183). Fat mass was a more important predictor of TBBMC and TBBMD in females (semi-partial R 2 0.126 and 0.039, respectively) than males (semi-partial R 2 0.006 and 0.018, respectively). Trunk-to-limb fat mass ratio had a weak, negative association with TBBMC and bone area in both genders (semi-partial R 2 0.004 to 0.034). Conclusions: Lean body mass has strong positive relationship with total body bone mass in both genders. Fat mass may play a positive role in peak bone mass attainment in women but the association was weaker in men; different fat compartments may have different effects. © 2014 International Osteoporosis Foundation and National Osteoporosis Foundation.
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2014 |
Grace T, Bulsara M, Pennell C, Hands B, 'Maternal hypertensive diseases negatively affect offspring motor development', Pregnancy Hypertension, 4 209-214 (2014)
Objective Hypertension in pregnancy and preeclampsia have been linked to poor outcomes in cognitive, mental and psychomotor development; however, few longitudinal studies have res... [more]
Objective Hypertension in pregnancy and preeclampsia have been linked to poor outcomes in cognitive, mental and psychomotor development; however, few longitudinal studies have researched their effect on offspring motor development, particularly in late childhood and adolescence. The purpose of this study was to determine if maternal hypertensive diseases during pregnancy are a risk factor for compromised motor development at 10, 14, and 17 years. Study design Longitudinal cohort study using data from the Western Australian Pregnancy Cohort Study (Raine). Main outcome measure Offspring (n = 2868) were classified by their maternal blood pressure profiles during pregnancy: normotension (n = 2133), hypertension (n = 626) and preeclampsia (n = 109). Offspring motor development, at 10, 14, and 17 years was measured by the Neuromuscular Developmental Index (NDI) of the McCarron Assessment of Motor Development (MAND). Methods Linear mixed models were used to compare outcomes between pregnancy groups. Results Offspring from pregnancies complicated by preeclampsia had poorer motor outcomes at all ages than offspring from either normotensive mothers (p = 0.001) or those with hypertension (p = 0.002). Conclusion Hypertensive diseases during pregnancy, in particular preeclampsia, have long term and possibly permanent consequences for motor development of offspring. © 2014 International Society for the Study of Hypertension in Pregnancy Published by Elsevier B.V. All rights reserved.
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2014 |
Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion M-JA, et al., 'Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.', Mol Psychiatry, 19 253-258 (2014)
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2014 |
St Pourcain B, Cents RAM, Whitehouse AJO, Haworth CMA, Davis OSP, O'Reilly PF, et al., 'Common variation near ROBO2 is associated with expressive vocabulary in infancy', Nature Communications, 5 (2014)
© 2014 Macmillan Publishers Limited. All rights reserved. Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this ... [more]
© 2014 Macmillan Publishers Limited. All rights reserved. Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15-18 months, 'one-word stage', NTotal=8,889) and a later (24-30 months, 'two-word stage', NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3×10-8) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h15-18-months2=0.13, meta-GCTA h24-30-months2 =0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h24-months2=0.20).
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2014 |
Mcknight CM, Sherwin JC, Yazar S, Forward H, Tan AX, Hewitt AW, et al., 'Myopia in Young Adults Is Inversely Related to an Objective Marker of Ocular Sun Exposure: The Western Australian Raine Cohort Study', AMERICAN JOURNAL OF OPHTHALMOLOGY, 158 1079-1085 (2014)
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2014 |
White CRH, Doherty DA, Newnham JP, Pennell CE, 'The impact of introducing universal umbilical cord blood gas analysis and lactate measurement at delivery', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 54 71-78 (2014)
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2014 |
White CRH, Doherty DA, Newnham JP, Pennell CE, 'The Impact of Introducing Universal Umbilical Cord Blood Gas Analysis and Lactate Measurement at Delivery', OBSTETRICAL & GYNECOLOGICAL SURVEY, 69 307-308 (2014)
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2014 |
Oddy WH, Mori TA, Huang R-C, Marsh JA, Pennell CE, Chivers PT, et al., 'Early Infant Feeding and Adiposity Risk: From Infancy to Adulthood', ANNALS OF NUTRITION AND METABOLISM, 64 262-270 (2014)
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2014 |
Zhu K, Whitehouse AJO, Hart PH, Kusel M, Mountain J, Lye S, et al., 'Maternal Vitamin D Status During Pregnancy and Bone Mass in Offspring at 20 Years of Age: A Prospective Cohort Study', JOURNAL OF BONE AND MINERAL RESEARCH, 29 1088-1095 (2014)
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2014 |
Benke KS, Nivard MG, Velders FP, Walters RK, Pappa I, Scheet PA, et al., 'A Genome-wide Association Meta-analysis of Preschool Internalizing Problems', JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 53 667-676 (2014)
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2014 |
Forward H, Yazar S, Hewitt AW, Khan J, Mountain JA, Pesudovs K, et al., 'Multiple prenatal ultrasound scans and ocular development: 20-year follow-up of a randomized controlled trial', ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 44 166-170 (2014)
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2014 |
Perry JRB, Hsu Y-H, Chasman DI, Johnson AD, Elks C, Albrecht E, et al., 'DNA mismatch repair gene MSH6 implicated in determining age at natural menopause', HUMAN MOLECULAR GENETICS, 23 2490-2497 (2014)
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2014 |
Cousminer DL, Stergiakouli E, Berry DJ, Ang W, Groen-Blokhuis MM, Koerner A, et al., 'Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty', HUMAN MOLECULAR GENETICS, 23 4452-4464 (2014)
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2014 |
Hughes I, Harris M, Cotterill A, Garnett S, Bannink E, Pennell C, et al., 'Comparison of Centers for Disease Control and Prevention and World Health Organization references/standards for height in contemporary Australian children: Analyses of the Raine Study and Australian National Children's Nutrition and Physical Activity cohorts', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 50 895-901 (2014)
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2014 |
Anderson D, Holt BJ, Pennell CE, Holt PG, Hart PH, Blackwell JM, 'Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study', GENES AND IMMUNITY, 15 578-583 (2014)
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2014 |
Hart R, Doherty DA, Frederiksen H, Keelan JA, Hickey M, Sloboda D, et al., 'The influence of antenatal exposure to phthalates on subsequent female reproductive development in adolescence: a pilot study', REPRODUCTION, 147 379-390 (2014)
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2014 |
Rye MS, Scaman ESH, Thornton RB, Vijayasekaran S, Coates HL, Francis RW, et al., 'Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3', BMC MEDICAL GENETICS, 15 (2014)
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2014 |
Bolton JL, Hayward C, Direk N, Lewis JG, Hammond GL, Hill LA, et al., 'Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin', PLOS GENETICS, 10 (2014)
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2014 |
Newnham JP, Dickinson JE, Hart RJ, Pennell CE, Arrese CA, Keelan JA, 'Strategies to prevent preterm birth', FRONTIERS IN IMMUNOLOGY, 5 (2014)
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2014 |
Anderson LN, Briollais L, Atkinson HC, Marsh JA, Xu J, Connor KL, et al., 'Investigation of Genetic Variants, Birthweight and Hypothalamic- Pituitary- Adrenal Axis Function Suggests a Genetic Variant in the SERPINA6 Gene Is Associated with Corticosteroid Binding Globulin in the Western Australia Pregnancy Cohort ( Raine) Study', PLOS ONE, 9 (2014)
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2014 |
Heng YJ, Pennell CE, Chua HN, Perkins JE, Lye SJ, 'Whole Blood Gene Expression Profile Associated with Spontaneous Preterm Birth in Women with Threatened Preterm Labor', PLOS ONE, 9 (2014)
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2014 |
Warrington NM, Tilling K, Howe LD, Paternoster L, Pennell CE, Wu YY, Briollais L, 'Robustness of the linear mixed effects model to error distribution assumptions and the consequences for genome-wide association studies', STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, 13 567-587 (2014)
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2014 |
Loset M, Johnson MP, Melton PE, Ang W, Huang R-C, Mori TA, et al., 'Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22', PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 4 178-185 (2014)
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2014 |
Ferreira MAR, Matheson MC, Tang CS, Granell R, Ang W, Hui J, et al., 'Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133 1564-1571 (2014)
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2013 |
Kamara M, Henderson JJ, Doherty DA, Dickinson JE, Pennell CE, 'The risk of placenta accreta following primary elective caesarean delivery: A case-control study', Obstetrical and Gynecological Survey, 68 729-730 (2013)
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2013 |
Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, et al., 'Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference (Nature Genetics (2012) 44 (532-538))', Nature Genetics, 45 713 (2013)
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2013 |
Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, et al., 'Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume (Nature Genetics (2012) 44 (539-544))', Nature Genetics, 45 713 (2013)
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2013 |
Verhoeven VJM, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Höhn R, et al., 'Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia (Nature Genetics (2013) 45 (314-318))', Nature Genetics, 45 712 (2013)
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2013 |
Kamara M, Henderson JJ, Doherty DA, Dickinson JE, Pennell CE, 'The risk of placenta accreta following primary elective caesarean delivery: A case-control study', BJOG: An International Journal of Obstetrics and Gynaecology, 120 879-886 (2013)
Objective To evaluate the risk of placenta praevia accreta following primary (first) elective or primary emergency caesarean section in a pregnancy complicated by placenta praevia... [more]
Objective To evaluate the risk of placenta praevia accreta following primary (first) elective or primary emergency caesarean section in a pregnancy complicated by placenta praevia. Design Retrospective matched case-control study, employing variable matching. Setting Tertiary referral centre between 1993 and 2008. Population Sixty-five cases and 102 controls were used for the analysis from a total of 82 667 births during the study period. Methods Relevant data were abstracted from clinical records. Matching of cases with controls was based on co-existing placenta praevia, number of previous caesarean sections, and age, with one or two controls per case. Results are presented as odds ratios (ORs) with 95% confidence intervals (95% CIs). Main outcome measures Placenta accreta in a pregnancy complicated by placenta praevia following a primary elective or emergency caesarean section, and morbidity associated with pregnancies complicated by placenta accreta. Results Significantly more cases than controls had an elective caesarean section for their primary caesarean delivery (46.2 versus 18.6%; P < 0.001). There were no differences between groups for previous pregnancy loss, uterine surgery, and vaginal delivery, before or after the primary caesarean section. Compared with primary emergency caesarean section, primary elective caesarean section significantly increased the risk of placenta accreta in a subsequent pregnancy in the presence of placenta praevia (OR 3.00; 95% CI 1.47-6.12; P = 0.025). Conclusions Our results suggest that women with a primary elective caesarean section without labour are more likely, compared with those undergoing primary emergency caesarean section with labour, to develop an accreta in a subsequent pregnancy with placenta praevia. © 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.
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2013 |
Hammond G, Langridge A, Leonard H, Hagan R, Jacoby P, DeKlerk N, et al., 'Changes in risk factors for preterm birth in Western Australia 1984-2006.', BJOG, 120 1051-1060 (2013)
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2013 |
Fernandez-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T, et al., 'Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent', AMERICAN JOURNAL OF EPIDEMIOLOGY, 178 451-460 (2013)
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2013 |
Cheng C-Y, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, et al., 'Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error', AMERICAN JOURNAL OF HUMAN GENETICS, 93 264-277 (2013)
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2013 |
Robinson M, Whitehouse AJO, Zubrick SR, Pennell CE, Jacoby P, Mclean NJ, et al., 'Delivery at 37weeks' gestation is associated with a higher risk for child behavioural problems', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 53 143-151 (2013)
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2013 |
White CRH, Kohan R, Doherty DA, Newnham JP, Pennell CE, 'Attitudes and barriers to the introduction of umbilical cord blood gas and lactate analysis at birth', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 53 271-276 (2013)
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2013 |
Robinson M, Oddy WH, Whitehouse AJO, Pennell CE, Kendall GE, McLean NJ, et al., 'Hypertensive Diseases of Pregnancy Predict Parent-Reported Difficult Temperament in Infancy', JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 34 174-180 (2013)
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2013 |
Adams LA, White SW, Marsh JA, Lye SJ, Connor KL, Maganga R, et al., 'Association Between Liver-Specific Gene Polymorphisms and Their Expression Levels With Nonalcoholic Fatty Liver Disease', HEPATOLOGY, 57 590-600 (2013)
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2013 |
Pennell CE, Vadillo-Ortega F, Olson DM, Ha E-H, Williams S, Frayling TM, et al., 'Preterm Birth Genome Project (PGP) - validation of resources for preterm birth genome-wide studies', JOURNAL OF PERINATAL MEDICINE, 41 45-49 (2013)
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2013 |
Reynolds RM, Hii HL, Pennell CE, McKeague IW, de Kloet ER, Lye S, et al., 'Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis', PSYCHONEUROENDOCRINOLOGY, 38 1271-1280 (2013)
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2013 |
Reynolds RM, Hii HL, Pennell CE, McKeague IW, Kloet ERD, Lye S, et al., 'Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis', Psychoneuroendocrinology, 38 1271-1280 (2013)
Dysfunctional regulation of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an important biological mechanism underlying stress-related diseases; however, a bet... [more]
Dysfunctional regulation of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an important biological mechanism underlying stress-related diseases; however, a better understanding of the interlinked neuroendocrine events driving the release of cortisol by this stress axis is essential for progress in preventing or halting irreversible development of adverse HPA-function. We aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation and establishment of a lasting set point level of HPA function. A total of 1258 participants (mean age 16.6 years) recruited from the Western Australian Pregnancy (Raine) Cohort provided fasting morning blood and saliva samples for basal HPA activity assessment. Irrespective of gender, linear regression modelling identified a positive correlation between the main components of the HPA-cascade of events, ACTH, total cortisol and free cortisol in saliva. Corticosteroid binding globulin (CBG) was inversely associated with free cortisol in saliva, an effect most clearly observed in boys. ACTH levels were lower, but cortisol levels were higher in girls than in boys. Girls may also be exposed to more bioactive cortisol, based on higher average free cortisol measured in saliva at awakening. These relatively higher female free cortisol levels were significantly reduced by oral contraceptive use, eliminating the gender specific difference in salivary cortisol. Free plasma cortisol, calculated from total circulating cortisol and CBG concentrations, was also significantly reduced in girls using oral contraceptives, possibly via an enhancing effect of oral contraceptives on blood CBG content. This study highlights a clear gender difference in HPA activity under non-stressful natural conditions. This finding may be relevant for research into sex-specific stress-related diseases with a typical onset in late adolescence. © 2012 Elsevier Ltd.
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2013 |
Cousminer DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, et al., 'Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity', HUMAN MOLECULAR GENETICS, 22 2735-2747 (2013)
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2013 |
Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, et al., 'New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism', NATURE GENETICS, 45 76-U115 (2013)
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2013 |
Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A, et al., 'Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus', NATURE GENETICS, 45 155-163 (2013)
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2013 |
Verhoeven VJM, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Hoehn R, et al., 'Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia', NATURE GENETICS, 45 314-318 (2013)
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2013 |
Bonnelykke K, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, et al., 'Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization', NATURE GENETICS, 45 902-U290 (2013)
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2013 |
Yazar S, Mishra A, Ang W, Kearns LS, Mountain JA, Pennell C, et al., 'Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: Results of a genome-wide association study', MOLECULAR VISION, 19 1238-1246 (2013)
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2013 |
Yazar S, Forward H, McKnight CM, Tan A, Soloshenko A, Oates SK, et al., 'Raine Eye Health Study: Design, Methodology and Baseline Prevalence of Ophthalmic Disease in a Birth-cohort Study of Young Adults', OPHTHALMIC GENETICS, 34 199-208 (2013)
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2013 |
McDonald SW, Lyon AW, Benzies KM, McNeil DA, Lye SJ, Dolan SM, et al., 'The All Our Babies pregnancy cohort: design, methods, and participant characteristics', BMC PREGNANCY AND CHILDBIRTH, 13 (2013)
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2013 |
Moeller MIP, Henderson JJ, Nathan EA, Pennell CE, 'Cervilenz (TM) is an effective tool for screening cervical-length in comparison to transvaginal ultrasound', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 26 378-382 (2013)
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2013 |
Davidoff DF, Dickinson JE, Warner T, Pennell CE, 'Twin-Twin Transfusion Syndrome and Twin Anemia-Polycythemia Sequence in a Monochorionic Triamniotic Pregnancy', TWIN RESEARCH AND HUMAN GENETICS, 16 716-719 (2013)
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2013 |
Langridge AT, Glasson EJ, Nassar N, Jacoby P, Pennell C, Hagan R, et al., 'Maternal Conditions and Perinatal Characteristics Associated with Autism Spectrum Disorder and Intellectual Disability', PLOS ONE, 8 (2013)
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2013 |
Warrington NM, Wu YY, Pennell CE, Marsh JA, Beilin LJ, Palmer LJ, et al., 'Modelling BMI Trajectories in Children for Genetic Association Studies', PLOS ONE, 8 (2013)
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2013 |
Warrington NM, Howe LD, Wu YY, Timpson NJ, Tilling K, Pennell CE, et al., 'Association of a Body Mass Index Genetic Risk Score with Growth throughout Childhood and Adolescence', PLOS ONE, 8 (2013)
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2013 |
Howe LD, Parmar PG, Paternoster L, Warrington NM, Kemp JP, Briollais L, et al., 'Genetic Influences on Trajectories of Systolic Blood Pressure Across Childhood and Adolescence', CIRCULATION-CARDIOVASCULAR GENETICS, 6 608-614 (2013)
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2013 |
Robinson M, Zubrick SR, Pennell CE, Van Lieshout RJ, Jacoby P, Beilin LJ, et al., 'Pre-pregnancy maternal overweight and obesity increase the risk for affective disorders in offspring', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 4 42-48 (2013)
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2013 |
Parmar PG, Marsh JA, Taal HR, Kowgier M, Uitterlinden AG, Rivadeneira F, et al., 'Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 4 157-169 (2013)
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2013 |
St Pourcain B, Whitehouse AJO, Ang WQ, Warrington NM, Glessner JT, Wang K, et al., 'Common variation contributes to the genetic architecture of social communication traits', MOLECULAR AUTISM, 4 (2013)
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2012 |
Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, et al., 'Common variants at 12q15 and 12q24 are associated with infant head circumference', NATURE GENETICS, 44 532-+ (2012)
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2012 |
Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, et al., 'Common variants at 6q22 and 17q21 are associated with intracranial volume', NATURE GENETICS, 44 539-+ (2012)
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2012 |
McKnight CM, Newnham JP, Stanley FJ, Mountain JA, Landau LI, Beilin LJ, et al., 'Birth of a cohort The first 20 years of the raine study', Medical Journal of Australia, 197 608-610 (2012)
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2012 |
Robinson M, Mattes E, Oddy WH, Pennell CE, Van Eekelen A, Mclean NJ, et al., 'Erratum: Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events (Development and Psychopathology (2011) 23 (507-520))', Development and Psychopathology, 24 (2012)
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2012 |
Johnson M, Løset M, Brennecke S, Peralta J, Dyer T, East C, et al., 'OS049. Exome sequencing identifies likely functional variantsinfluencing preeclampsia and CVD risk.', Pregnancy hypertension, 2 203-204 (2012)
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2012 |
Løset M, Johnson MP, Pennell C, Huang R-C, Mori T, Beilin L, et al., 'OS070. Shared genetic risk factors for preeclampsia and cardiovascular disease.', Pregnancy hypertension, 2 214-215 (2012)
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2012 |
Webb TR, Matarin M, Gardner JC, Kelberman D, Hassan H, Ang W, et al., 'X-Linked Megalocornea Caused by Mutations in CHRDL1 Identifies an Essential Role for Ventroptin in Anterior Segment Development', AMERICAN JOURNAL OF HUMAN GENETICS, 90 247-259 (2012)
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2012 |
Paternoster L, Standl M, Chen C-M, Ramasamy A, Bonnelykke K, Duijts L, et al., 'Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis', NATURE GENETICS, 44 187-192 (2012)
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2012 |
Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, et al., 'A genome-wide association meta-analysis identifies new childhood obesity loci', NATURE GENETICS, 44 526-+ (2012)
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2012 |
Skouen JS, Smith AJ, Warrington NM, O' Sullivan PB, McKenzie L, Pennell CE, Straker LM, 'Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents', EUROPEAN JOURNAL OF PAIN, 16 1232-1242 (2012)
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2012 |
White CRH, Doherty DA, Kohan R, Newnham JP, Pennell CE, 'Evaluation of selection criteria for validating paired umbilical cord blood gas samples: an observational study', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 119 857-865 (2012)
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2012 |
White CRH, Mok T, Doherty DA, Henderson JJ, Newnham JP, Pennell CE, 'The effect of time, temperature and storage device on umbilical cord blood gas and lactate measurement: a randomized controlled trial', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 587-594 (2012)
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2012 |
Henderson JJ, McWilliam OA, Newnham JP, Pennell CE, 'Preterm birth aetiology 2004-2008. Maternal factors associated with three phenotypes: spontaneous preterm labour, preterm pre-labour rupture of membranes and medically indicated preterm birth', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 642-647 (2012)
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2012 |
White CRH, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE, 'Accurate prediction of hypoxic-ischaemic encephalopathy at delivery: a cohort study', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 1653-1659 (2012)
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2012 |
Hunter TJ, Byrnes MJ, Nathan E, Gill A, Pennell CE, 'Factors influencing survival in pre-viable preterm premature rupture of membranes', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 1755-1761 (2012)
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2012 |
Huang R-C, Galati JC, Burrows S, Beilin LJ, Li X, Pennell CE, et al., 'DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults', CLINICAL EPIGENETICS, 4 (2012)
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2012 |
Boraska V, Day-Williams A, Franklin CS, Elliott KS, Panoutsopoulou K, Tachmazidou I, et al., 'Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts', PLOS ONE, 7 (2012)
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2012 |
Rye MS, Warrington NM, Scaman ESH, Vijayasekaran S, Coates HL, Anderson D, et al., 'Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood', PLOS ONE, 7 (2012)
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2012 |
Scerri TS, Darki F, Newbury DF, Whitehouse AJO, Peyrard-Janvid M, Matsson H, et al., 'The Dyslexia Candidate Locus on 2p12 Is Associated with General Cognitive Ability and White Matter Structure', PLOS ONE, 7 (2012)
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2012 |
Marsh JA, Pennell CE, Warrington NM, Mook-Kanamori D, Briollais L, Lye SJ, et al., 'Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: an effect that is reversed in the offspring of smoking mothers', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 3 10-20 (2012)
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2012 |
Meyerkort CE, Oddy WH, O'Sullivan TA, Henderson J, Pennell CE, 'Early diet quality in a longitudinal study of Australian children: associations with nutrition and body mass index later in childhood and adolescence', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 3 21-31 (2012)
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2012 |
Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, Rayner NW, et al., 'Genome-wide meta-analysis of common variant differences between men and women', HUMAN MOLECULAR GENETICS, 21 4805-4815 (2012)
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2012 |
McKnight CM, Newnham JP, Stanley FJ, Mountain JA, Landau LI, Beilin LJ, et al., 'Birth of a cohort - the first 20 years of the Raine study', MEDICAL JOURNAL OF AUSTRALIA, 197 608-610 (2012)
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2012 |
Van Eekelen JAM, Ellis JA, Pennell CE, Craig J, Saffery R, Mattes E, Olsson CA, 'Stress-sensitive neurosignalling in depression: An integrated network biology approach to candidate gene selection for genetic association analysis', Mental Illness, 4 105-114 (2012)
© J.A.M. van Eekelen et al., 2012. Genetic risk for depressive disorders is poorly understood despite consistent suggestions of a high heritable component. Most genetic studies ha... [more]
© J.A.M. van Eekelen et al., 2012. Genetic risk for depressive disorders is poorly understood despite consistent suggestions of a high heritable component. Most genetic studies have focused on risk associated with single variants, a strategy which has so far only yielded small (often non-replicable) risks for depressive disorders. In this paper we argue that more substantial risks are likely to emerge from genetic variants acting in synergy within and across larger neurobiological systems (polygenic risk factors). We show how knowledge of major integrated neurobiological systems provides a robust basis for defining and testing theoretically defensible polygenic risk factors. We do this by describing the architecture of the overall stress response. Maladaptation via impaired stress responsiveness is central to the aetiology of depression and anxiety and provides a framework for a systems biology approach to candidate gene selection. We propose principles for identifying genes and gene networks within the neurosystems involved in the stress response and for defining polygenic risk factors based on the neurobiology of stressrelated behaviour. We conclude that knowledge of the neurobiology of the stress response system is likely to play a central role in future efforts to improve genetic prediction of depression and related disorders.
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2012 |
Myatt L, Eschenbach DA, Lye SJ, Mesiano S, Murtha AP, Williams SM, Pennell CE, 'A Standardized Template for Clinical Studies in Preterm Birth', REPRODUCTIVE SCIENCES, 19 474-482 (2012)
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2012 |
Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, et al., 'Common variants at 6q22 and 17q21 are associated with intracranial volume (vol 44, pg 539, 2012)', NATURE GENETICS, 44 732-732 (2012) |
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2012 |
Whitehouse AJO, 'CNTNAP2 variants affect early language development in the general population (vol 10, pg 451, 2011)', GENES BRAIN AND BEHAVIOR, 11 501-501 (2012)
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2012 |
Whitehouse AJO, Mattes E, Maybery MT, Dissanayake C, Sawyer M, Jones RM, et al., 'Perinatal testosterone exposure and autistic-like traits in the general population: a longitudinal pregnancy-cohort study', JOURNAL OF NEURODEVELOPMENTAL DISORDERS, 4 (2012)
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2012 |
Bonilla C, Lawlor DA, Taylor AE, Gunnell DJ, Ben-Shlomo Y, Ness AR, et al., 'Vitamin B-12 Status during Pregnancy and Child's IQ at Age 8: A Mendelian Randomization Study in the Avon Longitudinal Study of Parents and Children', PLOS ONE, 7 (2012)
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2012 |
Mishra A, Yazar S, Hewitt AW, Mountain JA, Ang W, Pennell CE, et al., 'Genetic Variants near PDGFRA Are Associated with Corneal Curvature in Australians', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53 7131-7136 (2012)
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2012 |
Hart R, Doherty DA, Pennell CE, Newnham IA, Newnham JP, 'Periodontal disease: a potential modifiable risk factor limiting conception', HUMAN REPRODUCTION, 27 1332-1342 (2012)
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2012 |
Whitehouse AJO, Robinson M, Newnham JP, Pennell CE, 'Do hypertensive diseases of pregnancy disrupt neurocognitive development in offspring?', PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 26 101-108 (2012)
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2012 |
Mackey DA, Warrington NM, Hewitt AW, Oates SK, Yazar S, Soloshenko A, et al., 'Role of the TCF4 Gene Intronic Variant in Normal Variation of Corneal Endothelium', CORNEA, 31 162-166 (2012)
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2012 |
Abarin T, Wu YY, Warrington N, Lye S, Pennell C, Briollais L, 'The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 41 1650-1660 (2012)
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2012 |
Adams LA, Marsh JA, Ayonrinde OT, Olynyk JK, Ang WQ, Beilin LJ, et al., 'Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 27 1520-1527 (2012)
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2012 |
Middelberg RP, Benyamin B, de Moor MHM, Warrington NM, Gordon S, Henders AK, et al., 'Loci affecting gamma-glutamyl transferase in adults and adolescents show age x SNP interaction and cardiometabolic disease associations', HUMAN MOLECULAR GENETICS, 21 446-455 (2012)
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2012 |
Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion M-JA, et al., 'Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5CHRNA3CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight', HUMAN MOLECULAR GENETICS, 21 5344-5358 (2012)
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2011 |
van Eekelen JAM, Olsson CA, Ellis JA, Ang W, Hutchinson D, Zubrick SR, Pennell CE, 'Identification and genetic determination of an early life risk disposition for depressive disorder: Atypical stress-related behaviour in early childhood', AUSTRALIAN JOURNAL OF PSYCHOLOGY, 63 6-17 (2011)
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2011 |
Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, et al., 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function', NATURE GENETICS, 43 1082-1090 (2011)
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2011 |
White CRH, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE, 'Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit', Obstetrical and Gynecological Survey, 66 14-15 (2011)
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2011 |
Pennell CE, Henderson JJ, O'Neill MJ, McCleery S, Doherty DA, Dickinson JE, 'Erratum: Induction of labour in nulliparous women with an unfavourable cervix: a randomised controlled trial comparing double and single balloon catheters and PGE
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2011 |
Henderson JJ, Pennell CE, Dickinson JE, 'Transcervical Foley catheter should be used in preference to intravaginal prostaglandins for induction of labor with an unfavorable cervix', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 205 E19-E20 (2011)
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2011 |
Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, et al., 'Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children', DIABETES, 60 1805-1812 (2011)
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2011 |
Mook-Kanamori DO, Marsh JA, Warrington NM, Taal HR, Newnham JP, Beilin LJ, et al., 'Variants near CCNL1/LEKR1 and in ADCY5 and Fetal Growth Characteristics in Different Trimesters', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96 E810-E815 (2011)
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2011 |
Whitehouse AJO, Hickey M, Stanley FJ, Newnham JP, Pennell CE, 'Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder', JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 41 122-129 (2011)
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2011 |
Robinson M, Pennell CE, McLean NJ, Oddy WH, Newnham JP, 'The over-estimation of risk in pregnancy', JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY, 32 53-58 (2011)
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2011 |
Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Pennell CE, de Klerk N, et al., 'Gender-Specific Differences in Adipose Distribution and Adipocytokines Influence Adolescent Nonalcoholic Fatty Liver Disease', HEPATOLOGY, 53 800-809 (2011)
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2011 |
Robinson M, Mattes E, Oddy WH, Pennell CE, van Eekelen A, McLean NJ, et al., 'Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events', DEVELOPMENT AND PSYCHOPATHOLOGY, 23 507-520 (2011)
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2011 |
Rye MS, Wiertsema SP, Scaman ESH, Oommen J, Sun W, Francis RW, et al., 'FBXO11, a regulator of the TGF beta pathway, is associated with severe otitis media in Western Australian children', GENES AND IMMUNITY, 12 352-359 (2011)
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2011 |
Gracie S, Pennell C, Ekman-Ordeberg G, Lye S, McManaman J, Williams S, et al., 'An integrated systems biology approach to the study of preterm birth using "-omic" technology - a guideline for research', BMC PREGNANCY AND CHILDBIRTH, 11 (2011)
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2011 |
Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, Palmer CNA, et al., 'Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development', PLOS GENETICS, 7 (2011)
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2011 |
Paracchini S, Ang QW, Stanley FJ, Monaco AP, Pennell CE, Whitehouse AJO, 'Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population', GENES BRAIN AND BEHAVIOR, 10 158-165 (2011)
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2011 |
Whitehouse AJO, Bishop DVM, Ang QW, Pennell CE, Fisher SE, 'CNTNAP2 variants affect early language development in the general population', GENES BRAIN AND BEHAVIOR, 10 451-456 (2011)
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2011 |
Ronald A, Pennell CE, Whitehouse AJO, 'Prenatal maternal stress associated with ADHD and autistic traits in early childhood', FRONTIERS IN PSYCHOLOGY, 2 (2011)
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2011 |
Ferreira MAR, Matheson MC, Duffy DL, Marks GB, Hui J, Le Souef P, et al., 'Identification of IL6R and chromosome 11q13.5 as risk loci for asthma', LANCET, 378 1006-1014 (2011)
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2011 |
Kilpelaeinen TO, den Hoed M, Ong KK, Grontved A, Brage S, Jameson K, et al., 'Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals', AMERICAN JOURNAL OF CLINICAL NUTRITION, 93 851-860 (2011)
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2010 |
White CRH, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE, 'Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 50 318-328 (2010)
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2010 |
Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, et al., 'Low-Moderate Prenatal Alcohol Exposure and Risk to Child Behavioral Development: A Prospective Cohort Study EDITORIAL COMMENT', OBSTETRICAL & GYNECOLOGICAL SURVEY, 65 759-760 (2010)
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2010 |
Whitehouse AJO, Robinson M, Zubrick SR, Ang QW, Stanley FJ, Pennell CE, 'Maternal life events during pregnancy and offspring language ability in middle childhood: The Western Australian Pregnancy Cohort Study', EARLY HUMAN DEVELOPMENT, 86 487-492 (2010)
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2010 |
Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, et al., 'Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight', NATURE GENETICS, 42 430-U73 (2010)
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2010 |
Pennell CE, Henderson JJ, Dickinson JE, 'Induction of labour in nulliparous women with an unfavourable cervix Authors' Reply', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 117 892-893 (2010)
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2010 |
Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, et al., 'Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 117 1139-1150 (2010)
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2010 |
Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, et al., 'Child behaviour following low to moderate maternal drinking in pregnancy Reply', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 117 1564-1565 (2010)
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2010 |
Gracie SK, Lyon AW, Kehler HL, Pennell CE, Dolan SM, McNeil DA, et al., 'All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment', BMC PREGNANCY AND CHILDBIRTH, 10 (2010)
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2010 |
Pennell CE, Henderson JJ, O'Neill MJ, McCleery S, Doherty DA, Dickinson JE, 'Induction of Labor in Nulliparous Women With an Unfavorable Cervix: A Randomized Controlled Trial Comparing Double and Single Balloon Catheters and PGE2 Gel EDITORIAL COMMENT', OBSTETRICAL & GYNECOLOGICAL SURVEY, 65 78-80 (2010)
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2010 |
Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, et al., 'Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies', NATURE GENETICS, 42 1077-U73 (2010)
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2009 |
Newnham JP, Newnham IA, Ball CM, Wright M, Pennell CE, Swain J, Doherty DA, 'Treatment of Periodontal Disease During Pregnancy A Randomized Controlled Trial', OBSTETRICS AND GYNECOLOGY, 114 1239-1248 (2009)
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2009 |
Knight BS, Sunn N, Pennell CE, Adamson SL, Lye SJ, 'Developmental regulation of cardiovascular function is dependent on both genotype and environment', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 297 H2234-H2241 (2009)
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2009 |
Newnham JP, Pennell CE, Lye SJ, Rampono J, Challis JRG, 'Early Life Origins of Obesity', OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 36 227-+ (2009)
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2009 |
Pennell CE, Henderson JJ, O'Neill MJ, McCleery S, Doherty DA, Dickinson JE, 'Induction of labour in nulliparous women with an unfavourable cervix: a randomised controlled trial comparing double and single balloon catheters and PGE(2) gel', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 116 1443-1452 (2009)
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2008 |
Biggio J, Christiaens I, Katz M, Menon R, Merialdi M, Morken N-H, et al., 'A call for an international consortium on the genetics of preterm birth', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 199 95-97 (2008)
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2007 |
Pennell CE, Jacobsson B, Williams SM, Buns RM, Muglia LJ, Dolan SM, et al., 'Genetic epidemiologic studies of preterm birth: guidelines for research', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 196 107-118 (2007)
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2007 |
Pennell CE, Muglia LJ, Relton C, 'Genetic epidemiologic studies of preterm birth: studies of disease or of "rescue by birth"?', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 197 439-439 (2007)
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2007 |
Sloboda DM, Hart R, Doherty DA, Pennell CE, Hickey M, 'Rapid communication - Age at menarche: Influences of prenatal and postnatal growth', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 92 46-50 (2007)
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2007 |
Knight BS, Pennell CE, Adamson SL, Lye SJ, 'The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy', JOURNAL OF PHYSIOLOGY-LONDON, 581 873-881 (2007)
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2007 |
Knight BS, Pennell CE, Shah R, Lye SJ, 'Strain differences in the impact of dietary restriction on fetal growth and pregnancy in mice', REPRODUCTIVE SCIENCES, 14 81-90 (2007)
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2007 |
O'Leary CM, de Klerk N, Keogh J, Pennell C, de Groot J, York L, et al., 'Trends in mode of delivery during 1984-2003: can they be explained by pregnancy and delivery complications?', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 114 855-864 (2007)
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2001 |
Rogers MS, Murray HG, Wang CC, Pennell CE, Turner A, Yan P, et al., 'Oxidative stress in the fetal lamb brain following intermittent umbilical cord occlusion: a path analysis', BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 108 1283-1290 (2001)
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1999 |
Pennell CE, Tracy MB, 'A new method for rapid measurement of lactate in fetal and neonatal blood', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 39 227-233 (1999)
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Fawcett KA, Obeidat M, Melbourne C, Shrine N, Guyatt AL, John C, et al., 'Variants associated with HHIP expression have sex-differential effects on lung function', Wellcome Open Research, 5 111-111
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Wang C, Attia J, Lye S, Oddy W, Beilin L, Mori T, et al., 'Precision Medicine, Developmental Plasticity and Prevention of Non-Communicable Disease
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