Professor Craig Pennell

Professor Craig Pennell

Chair of Obstetrics and Gynecology

School of Medicine and Public Health

Career Summary

Biography


Craig Pennell is Chair in Obstetrics and Gynaecology and Professor in Maternal Fetal Medicine at the University of Newcastle (John Hunter Hospital). He is also senior researcher at HMRI in the Mothers and Babies Research Centre within the Priority Research Centre in Reproductive Health and Chair of the National Scientific Advisory Group of Red Nose.

Craig’s research can best be categorised into personalised medicine in perinatal health and the developmental origins of health and disease. His research is focussed on the use of genetics and genomics to predict and prevent preterm birth and non-communicable diseases (NCD).

Over his research careerhe has written more than 200 papers with 4 in Nature, 19 in Nature Genetics and 5 in Nature Communications. He has been citied over 9100 times and been awarded more than $28M in competitive research grants.


Outside of working really hard, he likes to cook for his wife, travel with his sons and ride his bike


Qualifications

  • Doctor of Philosophy, University of Western Australia
  • Bachelor of Medicine, Bachelor of Surgery (Hons), University of Adelaide

Keywords

  • Developmental origins of health and disease
  • Genetics
  • Genomics
  • Maternal Fetal Medicine
  • Obstetrics and Gynaecology
  • Preconception care
  • Preterm birth prevention
  • Research governance
  • Stillbirth
  • Transcriptomics

Languages

  • English (Mother)

Fields of Research

Code Description Percentage
111706 Epidemiology 30
111716 Preventive Medicine 30
060405 Gene Expression (incl. Microarray and other genome-wide approaches) 40

Professional Experience

UON Appointment

Title Organisation / Department
Chair of Obstetrics and Gynecology University of Newcastle
School of Medicine and Public Health
Australia

Awards

Award

Year Award
2012 Pride of Australia Award
Pride of Australia
2008 Award for Excellence in Teaching
The University of Western Australia
2003 Forrest Fellowship in Maternal Fetal Medicine
Women and Infants Research Foundation
2003 Fotheringham Research Fellowship
Royal Australian and New Zealand College of Obstetricians and Gynaecologists
2002 Presidents Presenter Award
Society of Gynecologic Investigation
2000 Young Investigator Award
Perinatal Society of Australia and New Zealand
1999 Nepean Medal for Research Excellence
Wentworth Area Health Service
1989 The Wood Jones and Herbert John Wilkinson Prize in Anatomy
The University of Adelaide
1988 The Christopher and John Campbell Prise for Biochemistry
The University of Adelaide
1987 Elder Prize
The University of Adelaide

Distinction

Year Award
2004 Distinction for Doctorate in Philosophy
The University of Western Australia

Honours

Year Award
1993 Bachelor of Medicine and Bachelor of Surgery with Honours
The University of Adelaide

Prize

Year Award
2012 Aspire Professional Development Award
The University of Western Australia
2004 Atheistan and Amy Saw Postdoctoral Research Fellowship
The University of Western Australia

Teaching

Code Course Role Duration
MEDI4015 Women and Childrens Health
John Hunter Hospital, Newcastle
Course Convenor 4/07/2018 - 31/12/2049
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2009 Pennell Dr CE, Palmer LJ, Knight BS, Relton C, Lye SJ, 'Approaches to evaluate gene-environment interactions underlying the developmental origins of health and disease', Early Life Origins of Human Health and Disease 205-217 (2009)
DOI 10.1159/000221166
Citations Scopus - 3

Journal article (216 outputs)

Year Citation Altmetrics Link
2019 White SW, Cheng JC, Penova-Veselinovic B, Wang C, White M, Ingleby B, et al., 'Single dose v two-dose antenatal anti-D prophylaxis: a randomised controlled trial.', Med J Aust, 211 261-265 (2019)
DOI 10.5694/mja2.50266
Citations Scopus - 1
2019 Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, et al., 'Erratum: Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology (The American Journal of Human Genetics (2019) 105(1) (15 28), (S0002929719301880), (10.1016/j.ajhg.2019.05.002))', American Journal of Human Genetics, 105 670-671 (2019)

© 2019 American Society of Human Genetics (The American Journal of Human Genetics 105, 15¿28; July 3, 2019) In the originally published version of this article, the effect sizes f... [more]

© 2019 American Society of Human Genetics (The American Journal of Human Genetics 105, 15¿28; July 3, 2019) In the originally published version of this article, the effect sizes for the previously reported loci achieving exome-wide significance (indicated with asterisks in the table below) were incorrect. The table has now been corrected online, and the authors apologize for this error. [Table presented]

DOI 10.1016/j.ajhg.2019.08.001
2019 Huang T, Sun D, Heianza Y, Bergholdt HKM, Gao M, Fang Z, et al., 'Dairy intake and body composition and cardiometabolic traits among adults: Mendelian randomization analysis of 182041 individuals from 18 studies', Clinical Chemistry, 65 751-760 (2019)

© 2019 American Association for Clinical Chemistry. BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed... [more]

© 2019 American Association for Clinical Chemistry. BACKGROUND: Associations between dairy intake and body composition and cardiometabolic traits have been inconsistently observed in epidemiological studies, and the causal relationship remains ill-defined. METHODS: We performed Mendelian randomization analysis using an established genetic variant located upstream of the lactase gene (LCT-13910 C/T, rs4988235) associated with dairy intake as an instrumental variable (IV). The causal effects of dairy intake on body composition and cardiometabolic traits (lipids, glycemic traits, and inflammatory factors) were quantified by IV estimators among 182041 participants from 18 studies. RESULTS: Each 1 serving/day higher dairy intake was associated with higher lean mass [ß (SE) = 0.117 kg (0.035); P = 0.001], higher hemoglobin A1c [0.009% (0.002); P < 0.001], lower LDL [-0.014 mmol/L (0.006); P = 0.013], total cholesterol (TC) [-0.012 mmol/L (0.005); P = 0.023], and non-HDL [-0.012 mmol/L (0.005); P = 0.028]. The LCT-13910 C/T CT + TT genotype was associated with 0.214 more dairy servings/day (SE = 0.047; P < 0.001), 0.284 cm higher waist circumference (SE = 0.118; P = 0.017), 0.112 kg higher lean mass (SE = 0.027; P = 3.8 × 10-5), 0.032 mmol/L lower LDL (SE = 0.009; P = 0.001), and 0.032 mmol/L lower TC (SE = 0.010; P = 0.001). Genetically higher dairy intake was associated with increased lean mass [0.523 kg per serving/day (0.170); P = 0.002] after correction for multiple testing (0.05/18). However, we find that genetically higher dairy intake was not associated with lipids and glycemic traits. CONCLUSIONS: The present study provides evidence to support a potential causal effect of higher dairy intake on increased lean mass among adults. Our findings suggest that the observational associations of dairy intake with lipids and glycemic traits may be the result of confounding.

DOI 10.1373/clinchem.2018.300335
Citations Scopus - 2Web of Science - 2
2019 Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, et al., 'Associations of autozygosity with a broad range of human phenotypes', Nature Communications, 10 (2019)

© 2019, The Author(s). In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importanc... [more]

© 2019, The Author(s). In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44¿66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.

DOI 10.1038/s41467-019-12283-6
2019 Rauschert S, Melton PE, Burdge G, Craig J, Godfrey KM, Holbrook JD, et al., 'Maternal smoking during pregnancy induces persistent epigenetic changes into adolescence, independent of postnatal smoke exposure and is associated with cardiometabolic risk', Frontiers in Genetics, 10 (2019) [C1]
DOI 10.3389/fgene.2019.00770
2019 Huang RC, Lillycrop KA, Beilin LJ, Godfrey KM, Anderson D, Mori TA, et al., 'Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular disease.', The Journal of clinical endocrinology and metabolism, 104 3012-3024 (2019) [C1]
DOI 10.1210/jc.2018-02076
Citations Scopus - 2Web of Science - 2
2019 Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, et al., 'Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution', NATURE GENETICS, 51 452-+ (2019)
DOI 10.1038/s41588-018-0334-2
Citations Scopus - 5Web of Science - 5
2019 Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, et al., 'Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration', Nature Communications, 10 1-13 (2019) [C1]
DOI 10.1038/s41467-019-11881-8
2019 Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, et al., 'Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.', Am J Hum Genet, 105 15-28 (2019)
DOI 10.1016/j.ajhg.2019.05.002
Citations Scopus - 2Web of Science - 1
2019 Hartwig FP, Davies NM, Horta BL, Ahluwalia TS, Bisgaard H, Bonnelykke K, et al., 'Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 48 45-57 (2019)
DOI 10.1093/ije/dyy273
2019 Middeldorp CM, Mahajan A, Horikoshi M, Robertson NR, Beaumont RN, Bradfield JP, et al., 'The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects', EUROPEAN JOURNAL OF EPIDEMIOLOGY, 34 279-300 (2019) [C1]
DOI 10.1007/s10654-019-00502-9
Citations Scopus - 1
2019 Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, et al., 'Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors', Nature Genetics, 51 804-814 (2019) [C1]

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has... [more]

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight¿blood pressure association is attributable to genetic effects, and not to intrauterine programming.

DOI 10.1038/s41588-019-0403-1
Citations Scopus - 6Web of Science - 4
2019 Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, et al., 'Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium', MOLECULAR PSYCHIATRY, 24 1920-1932 (2019)
DOI 10.1038/s41380-018-0079-4
Citations Scopus - 2Web of Science - 4
2019 Haworth S, Shapland CY, Hayward C, Prins BP, Felix JF, Medina-Gomez C, et al., 'Low-frequency variation in TP53 has large effects on head circumference and intracranial volume', NATURE COMMUNICATIONS, 10 (2019)
DOI 10.1038/s41467-018-07863-x
Citations Scopus - 2Web of Science - 3
2019 Zhu K, Oddy WH, Holt P, Ping-Delfos WCS, McVeigh J, Straker L, et al., 'Relationship Between Vitamin D Status From Childhood to Early Adulthood With Body Composition in Young Australian Adults', JOURNAL OF THE ENDOCRINE SOCIETY, 3 563-576 (2019)
DOI 10.1210/js.2018-00349
2019 Alves AC, De Silva NMG, Karhunen V, Sovio U, Das S, Rob Taal H, et al., 'GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI', Science Advances, 5 (2019)

Copyright © 2019 The Authors. Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully underst... [more]

Copyright © 2019 The Authors. Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

DOI 10.1126/sciadv.aaw3095
2019 Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, et al., 'A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity', Human molecular genetics, 28 3327-3338 (2019) [C1]

© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. Although hundreds of genome-wide asso... [more]

© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13¿005 cases (=95th percentile of body mass index (BMI) achieved 2-18¿years old) and 15¿599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1888 cases and 4689 controls from seven cohorts of European and North/South American ancestry. In addition to observing 18 previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene, METTL15). The variant was nominally associated with only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than 10 single nucleotide polymorphisms (SNPs) (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.

DOI 10.1093/hmg/ddz161
2018 Guastella AJ, Cooper MN, White CRH, White MK, Pennell CE, Whitehouse AJO, 'Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age?', Journal of Child Psychology and Psychiatry and Allied Disciplines, 59 1323-1332 (2018)

© 2018 Association for Child and Adolescent Mental Health. Background: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviou... [more]

© 2018 Association for Child and Adolescent Mental Health. Background: The neuropeptide and hormone oxytocin is known to have a significant impact on social cognition and behaviour in humans. There is growing concern regarding the influence of exogenous oxytocin (OT) administration in early life on later social and emotional development, including autism spectrum disorder (ASD). No study has examined offspring development in relation to the dose of exogenous oxytocin administered during labour. Methods: Between 1989 and 1992, 2,900 mothers were recruited prior to the 18th week of pregnancy, delivering 2,868 live offspring. The Child Behaviour Checklist was used to measure offspring behavioural difficulties at ages 5, 8, 10, 14 and 17¿years. Autism spectrum disorder was formally diagnosed by consensus of a team of specialists. At 20¿years, offspring completed a measure of autistic-like traits, the Autism Spectrum Quotient (AQ). Oxytocin exposure prior to birth was analysed using categorical and continuous approaches (maternal oxytocin dose) with univariate and multivariate statistical techniques. Results: Categorical analyses of oxytocin exposure prior to birth demonstrated no group differences in any measures of child behaviour. A small in magnitude dose¿response association was observed for clinically significant total behaviour symptoms (adjusted odds ratio 1.03; 95% CI: 1.01¿1.06, p¿<.01). Exogenous oxytocin administration prior to birth was not associated with ASD (OR: 0.64; 95% CI: 0.15¿2.12, p¿=.46) or high levels of autistic-like traits (p¿=.93), as assessed by the AQ. Conclusions: This study is the first to investigate longitudinal mental health outcomes associated with the use of oxytocin-based medications during labour. The results do not provide evidence to support the theory that exogenous OT has a clinically significant negative impact on the long-term mental health of children.

DOI 10.1111/jcpp.12924
Citations Scopus - 4
2018 Pels A, Mol BWJ, Singer J, Lee T, Von Dadelszen P, Ganzevoort W, et al., 'Influence of gestational age at initiation of antihypertensive therapy: Secondary analysis of CHIPS trial data (control of hypertension in pregnancy study)', Hypertension, 71 1170-1177 (2018)

© 2018 The Authors. For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, whi... [more]

© 2018 The Authors. For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, while minimizing any potentially negative effect on fetal growth, by delaying initiation of antihypertensive therapy until later in pregnancy. For the 981 women with nonsevere, chronic or gestational hypertension randomized to less-tight (target diastolic blood pressure, 100 mm Hg), or tight (target, 85 mm Hg) control, we used mixed-effects logistic regression to examine whether the effect of less-tight (versus tight) control on major outcomes was dependent on gestational age at randomization, adjusting for baseline factors as in the primary analysis and including an interaction term between gestational age at randomization and treatment allocation. Gestational age was considered categorically (quartiles) and continuously (linear or quadratic form), and the optimal functional form selected to provide the best fit to the data based on the Akaike information criterion. Randomization before (but not after) 24 weeks to less-tight (versus tight) control was associated with fewer babies with birth weight <10th centile (Pinteraction=0.005), but more preterm birth (Pinteraction=0.043), and no effect on perinatal death or high-level neonatal care >48 hours (Pinteraction=0.354). For the mother, less-tight (versus tight) control was associated with more severe hypertension at all gestational ages but particularly so before 28 weeks (Pinteraction=0.076). In women with nonsevere, chronic, or gestational hypertension, there seems to be no gestational age at which less-tight (versus tight) control is the preferred management strategy to optimize maternal or perinatal outcomes.

DOI 10.1161/HYPERTENSIONAHA.117.10689
Citations Scopus - 4
2018 Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, et al., 'Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity', NATURE GENETICS, 50 26-+ (2018)
DOI 10.1038/s41588-017-0011-x
Citations Scopus - 66Web of Science - 65
2018 Ayonrinde OT, Adams LA, Mori TA, Beilin LJ, de Klerk N, Pennell CE, et al., 'Sex differences between parental pregnancy characteristics and nonalcoholic fatty liver disease in adolescents', HEPATOLOGY, 67 108-122 (2018)
DOI 10.1002/hep.29347
Citations Scopus - 6Web of Science - 7
2018 Ali SB, Jeelall Y, Pennell CE, Hart R, McLean-Tooke A, Lucas M, 'The role of immunological testing and intervention in reproductive medicine: A fertile collaboration?', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 79 (2018)
DOI 10.1111/aji.12784
Citations Scopus - 3Web of Science - 2
2018 Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmueller J, Ang W, et al., 'Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks', NATURE GENETICS, 50 42-+ (2018)
DOI 10.1038/s41588-017-0014-7
Citations Scopus - 69Web of Science - 68
2018 Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, et al., 'Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent', MOLECULAR NUTRITION & FOOD RESEARCH, 62 (2018)
DOI 10.1002/mnfr.201700347
Citations Scopus - 2Web of Science - 2
2018 Mozooni M, Preen DB, Pennell CE, 'Stillbirth in Western Australia, 2005-2013: the influence of maternal migration and ethnic origin', The Medical journal of Australia, 209 394-400 (2018) [C1]

OBJECTIVE: To investigate prevalence rates and the risk of ante- and intrapartum stillbirth in Western Australia with respect to maternal country of birth and ethnic origin. DESIG... [more]

OBJECTIVE: To investigate prevalence rates and the risk of ante- and intrapartum stillbirth in Western Australia with respect to maternal country of birth and ethnic origin. DESIGN, SETTING AND PARTICIPANTS: Whole population retrospective cohort analysis of de-identified, linked routinely collected birth, perinatal and mortality data for all births to non-Indigenous women in WA during 2005-2013. MAIN OUTCOME MEASURES: Crude and adjusted odds ratios (aORs) with 95% confidence intervals were estimated by logistic regression and adjusted for confounding factors, for all stillbirths, antepartum stillbirths and intrapartum stillbirths, stratified by migrant status and ethnic background (white, Asian, Indian, African, Maori, other). RESULTS: Women born overseas were more likely to have a stillbirth than Australian-born women (aOR, 1.26; 95% CI, 1.09-1.37). There was no significant difference for any type of stillbirth between Australian-born women of white and non-white backgrounds, but non-white migrant women were more likely than white migrants to have a stillbirth (OR, 1.42; 95% CI, 1.19-1.70). Compared with Australian-born women, migrants of Indian (aOR, 1.71; 95% CI, 1.17-2.47), African (aOR, 2.12; 95% CI, 1.46-3.08), and "other" ethnic origins (aOR, 1.43; 95% CI, 1.06-1.93) were more likely to have antepartum stillbirths; women of African (aOR, 5.08; 95% CI, 3.14-8.22) and "other" (aOR, 1.86; 95% CI, 1.15-3.00) background were more likely to have an intrapartum stillbirth. CONCLUSIONS: Immigrants of African or Indian background appear to be at greater risk of ante- and intrapartum stillbirth in WA. Specific strategies are needed reduce the prevalence of stillbirth in these communities.

Citations Scopus - 3Web of Science - 2
2018 Porter MC, Pennell CE, Woods P, Dyer J, Merritt AJ, Currie BJ, 'Case Report: Chorioamnionitis and Premature Delivery due to Burkholderia pseudomallei Infection in Pregnancy', AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 98 797-799 (2018)
DOI 10.4269/ajtmh.17-0789
2018 McKeown NM, Dashti HS, Ma J, Haslam DE, Kiefte-de Jong JC, Smith CE, et al., 'Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis', Diabetologia, 61 317-330 (2018)

© 2017, Springer-Verlag GmbH Germany. Aims/hypothesis: Sugar-sweetened beverages (SSBs) are a major dietary contributor to fructose intake. A molecular pathway involving the carbo... [more]

© 2017, Springer-Verlag GmbH Germany. Aims/hypothesis: Sugar-sweetened beverages (SSBs) are a major dietary contributor to fructose intake. A molecular pathway involving the carbohydrate responsive element-binding protein (ChREBP) and the metabolic hormone fibroblast growth factor 21 (FGF21) may influence sugar metabolism and, thereby, contribute to fructose-induced metabolic disease. We hypothesise that common variants in 11 genes involved in fructose metabolism and the ChREBP-FGF21 pathway may interact with SSB intake to exacerbate positive associations between higher SSB intake and glycaemic traits. Methods: Data from 11 cohorts (six discovery and five replication) in the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided association and interaction results from 34,748 adults of European descent. SSB intake (soft drinks, fruit punches, lemonades or other fruit drinks) was derived from food-frequency questionnaires and food diaries. In fixed-effects meta-analyses, we quantified: (1) the associations between SSBs and glycaemic traits (fasting glucose and fasting insulin); and (2) the interactions between SSBs and 18 independent SNPs related to the ChREBP-FGF21 pathway. Results: In our combined meta-analyses of discovery and replication cohorts, after adjustment for age, sex, energy intake, BMI and other dietary covariates, each additional serving of SSB intake was associated with higher fasting glucose (ß¿±¿SE 0.014¿±¿0.004 [mmol/l], p¿=¿1.5¿×¿10-3) and higher fasting insulin (0.030¿±¿0.005 [loge pmol/l], p¿=¿2.0¿×¿10-10). No significant interactions on glycaemic traits were observed between SSB intake and selected SNPs. While a suggestive interaction was observed in the discovery cohorts with a SNP (rs1542423) in the ß-Klotho (KLB) locus on fasting insulin (0.030¿±¿0.011 loge pmol/l, uncorrected p¿=¿0.006), results in the replication cohorts and combined meta-analyses were non-significant. Conclusions/interpretation: In this large meta-analysis, we observed that SSB intake was associated with higher fasting glucose and insulin. Although a suggestive interaction with a genetic variant in the ChREBP-FGF21 pathway was observed in the discovery cohorts, this observation was not confirmed in the replication analysis. Trial registration: Trials related to this study were registered at clinicaltrials.gov as NCT00005131 (Atherosclerosis Risk in Communities), NCT00005133 (Cardiovascular Health Study), NCT00005121 (Framingham Offspring Study), NCT00005487 (Multi-Ethnic Study of Atherosclerosis) and NCT00005152 (Nurses¿ Health Study).

DOI 10.1007/s00125-017-4475-0
Citations Scopus - 7
2018 Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, et al., 'Maternal and fetal genetic contribution to gestational weight gain', International Journal of Obesity, 42 775-784 (2018)

© 2018 Macmillan Publishers Limited. part of Springer Nature. All rights reserved. Background:Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is cau... [more]

© 2018 Macmillan Publishers Limited. part of Springer Nature. All rights reserved. Background:Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG.Participants and methods:A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (for example, maternal body mass index (BMI) and glucose, birth weight).Results:Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explain variation in GWG. Variants near the pregnancy-specific beta-1 glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 × 10 â '8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birth weight variants were largely unrelated to GWG.Conclusions:We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring/maternal outcomes may be due to the relationship of maternal BMI and diabetes with GWG.

DOI 10.1038/ijo.2017.248
Citations Scopus - 9
2018 Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, et al., 'Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics', HUMAN MOLECULAR GENETICS, 27 742-756 (2018)
DOI 10.1093/hmg/ddx429
Citations Scopus - 40Web of Science - 34
2018 Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-Gomez C, Yakimov V, et al., 'Consortium-based genome-wide meta-analysis for childhood dental caries traits', HUMAN MOLECULAR GENETICS, 27 3113-3127 (2018)
DOI 10.1093/hmg/ddy237
Citations Scopus - 2Web of Science - 2
2018 Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, et al., 'Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis', NATURE GENETICS, 50 1072-+ (2018)
DOI 10.1038/s41588-018-0157-1
Citations Scopus - 8Web of Science - 7
2018 Waage J, Standl M, Curtin JA, Jessen LE, Thorsen J, Tian C, et al., 'Erratum to: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (Nature Genetics, (2018), 50, 8, (1072-1080), 10.1038/s41588-018-0157-1)', Nature Genetics, 50 1343 (2018)

© 2018, The Publisher. In the version of this article initially published, in Fig. 3, the y-axis numbering did not match the log scale indicated in the axis label. The error has b... [more]

© 2018, The Publisher. In the version of this article initially published, in Fig. 3, the y-axis numbering did not match the log scale indicated in the axis label. The error has been corrected in the HTML and PDF version of the article.

DOI 10.1038/s41588-018-0197-6
2018 Hart RJ, Doherty DA, Keelan JA, Minaee NS, Thorstensen EB, Dickinson JE, et al., 'The impact of antenatal Bisphenol A exposure on male reproductive function at 20-22 years of age', REPRODUCTIVE BIOMEDICINE ONLINE, 36 340-347 (2018)
DOI 10.1016/j.rbmo.2017.11.009
Citations Scopus - 8Web of Science - 7
2018 Hart RJ, Frederiksen H, Doherty DA, Keelan JA, Skakkebaek NE, Minaee NS, et al., 'The Possible Impact of Antenatal Exposure to Ubiquitous Phthalates Upon Male Reproductive Function at 20 Years of Age', FRONTIERS IN ENDOCRINOLOGY, 9 (2018)
DOI 10.3389/fendo.2018.00288
Citations Scopus - 4Web of Science - 2
2018 Blanken LME, Dass A, Alvares G, van der Ende J, Schoemaker NK, El Marroun H, et al., 'A prospective study of fetal head growth, autistic traits and autism spectrum disorder', AUTISM RESEARCH, 11 602-612 (2018)
DOI 10.1002/aur.1921
Citations Scopus - 2Web of Science - 2
2018 Warrington NM, Shevroja E, Hemani G, Hysi PG, Jiang Y, Auton A, et al., 'Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero', Human Molecular Genetics, 27 2025-2038 (2018) [C1]

© The Author(s) 2018. Published by Oxford University Press. All rights reserved. The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorph... [more]

© The Author(s) 2018. Published by Oxford University Press. All rights reserved. The ratio of the length of the index finger to that of the ring finger (2D:4D) is sexually dimorphic and is commonly used as a non-invasive biomarker of prenatal androgen exposure. Most association studies of 2D:4D ratio with a diverse range of sexspecific traits have typically involved small sample sizes and have been difficult to replicate, raising questions around the utility and precise meaning of the measure. In the largest genome-wide association meta-analysis of 2D:4D ratio to date (N=15 661, with replication N=75 821), we identified 11 loci (9 novel) explaining 3.8% of the variance in mean 2D:4D ratio. We also found weak evidence for association (b=0.06; P=0.02) between 2D:4D ratio and sensitivity to testosterone [length of the CAG microsatellite repeat in the androgen receptor (AR) gene] in females only. Furthermore, genetic variants associated with (adult) testosterone levels and/or sex hormone-binding globulin were not associated with 2D:4D ratio in our sample. Although we were unable to find strong evidence from our genetic study to support the hypothesis that 2D:4D ratio is a direct biomarker of prenatal exposure to androgens in healthy individuals, our findings do not explicitly exclude this possibility, and pathways involving testosterone may become apparent as the size of the discovery sample increases further. Our findings provide new insight into the underlying biology shaping 2D:4D variation in the general population.

DOI 10.1093/hmg/ddy121
Citations Scopus - 11Web of Science - 14
2017 Zhu K, Allen K, Mountain J, Lye S, Pennell C, Walsh JP, 'Depressive symptoms, body composition and bone mass in young adults: A prospective cohort study', International Journal of Obesity, 41 576-581 (2017)

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background:An association between depression and obesity is well recognised, but longitudinal st... [more]

© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Background:An association between depression and obesity is well recognised, but longitudinal studies of depressive symptoms in adolescents as a predictor of body composition are lacking.Objective:We examined depressive symptoms at age 14, 17 and 20 years as predictors of lean, fat and bone mass at age 20 years in a birth cohort.Subjects/Methods:In 1161 participants (569 females) in the Western Australia Pregnancy Cohort (Raine) Study, depressive symptoms were assessed using the Beck Depression Inventory for Youth at age 14 and 17 years, and the Depression, Anxiety and Stress Scale 21 at age 20 years. Participants were further classified into two trajectories using latent class analysis: no/transient and persistent/recurrent depression. At age 20 years, lean body mass (LBM), fat body mass (FBM) and total body bone mass were measured by dual-energy X-ray absorptiometry.Results:In females, accounting for age and lifestyle factors, depression scores at age 14 and 20 years were positively associated with body weight, body mass index (BMI), FBM and % FBM (r=0.110-0.184, P<0.05) but negatively correlated with % LBM (r=-0.120, P<0.05) at age 20 years. Females in the persistent/recurrent depression trajectory (n=99) had significantly higher body weight (+5.1 kg), BMI (+1.8 kg m -2), FBM (+3.9 kg) and % FBM (+2.2%) and significantly lower % LBM (-2.2%) at age 20 years than those with no/transient depression (n=470; all P<0.05). In males, depression scores at age 17 and 20 years were negatively associated with LBM but not weight or BMI, and depression trajectory was not a predictor of body composition at age 20 years. Depression scores and trajectories did not predict bone mass in either males or females.Conclusions:Depressive symptoms and persistent/recurrent depression in adolescence are predictors of greater adiposity at age 20 years in females, but not males, but do not predict bone mass in either gender.

DOI 10.1038/ijo.2016.214
Citations Scopus - 2
2017 Rietschel L, Streit F, Zhu G, McAloney K, Frank J, Couvy-Duchesne B, et al., 'Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes', Scientific Reports, 7 (2017)

© 2017 The Author(s). Hair cortisol concentration (HCC) is a promising measure of long-Term hypothalamus-pituitary-Adrenal (HPA) axis activity. Previous research has suggested an ... [more]

© 2017 The Author(s). Hair cortisol concentration (HCC) is a promising measure of long-Term hypothalamus-pituitary-Adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.

DOI 10.1038/s41598-017-11852-3
Citations Scopus - 10
2017 Zhu K, Oddy WH, Holt P, Ping-Delfos WCS, Mountain J, Lye S, et al., 'Tracking of vitamin D status from childhood to early adulthood and its association with peak bone mass', AMERICAN JOURNAL OF CLINICAL NUTRITION, 106 276-283 (2017)
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2017 Kreiner E, Waage J, Standl M, Brix S, Pers TH, Alves AC, et al., 'Shared genetic variants suggest common pathways in allergy and autoimmune diseases', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140 771-781 (2017)
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2017 Straker L, Mountain J, Jacques A, White S, Smith A, Landau L, et al., 'Cohort Profile: The Western Australian Pregnancy Cohort (Raine) Study-Generation 2', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 46 1384-+ (2017)
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2017 Herbison CE, Allen K, Robinson M, Newnham J, Pennell C, 'The impact of life stress on adult depression and anxiety is dependent on gender and timing of exposure', DEVELOPMENT AND PSYCHOPATHOLOGY, 29 1443-1454 (2017)
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2017 Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, et al., 'Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets', NATURE GENETICS, 49 416-425 (2017)
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2017 White SW, Eastwood PR, Straker LM, Adams LA, Newnham JP, Lye SJ, Pennell CE, 'The Raine study had no evidence of significant perinatal selection bias after two decades of follow up: a longitudinal pregnancy cohort study', BMC PREGNANCY AND CHILDBIRTH, 17 (2017)
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2017 Mace A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Noukas M, et al., 'CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits', NATURE COMMUNICATIONS, 8 (2017)
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2017 Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, et al., 'Rare and low-frequency coding variants alter human adult height', NATURE, 542 186-190 (2017)
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2016 Hart RJ, Doherty DA, Keelan JA, McLachlan R, Skakkebaek NE, Norman RJ, et al., 'Early Life Events Predict Adult Testicular Function; Data Derived From the Western Australian (Raine) Birth Cohort', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101 3333-3344 (2016)
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2016 Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, et al., 'Genome-wide associations for birth weight and correlations with adult disease', NATURE, 538 248-+ (2016)
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2016 Henley D, Brown S, Pennell C, Lye S, Torpy DJ, 'Evidence for central hypercortisolism and elevated blood pressure in adolescent offspring of mothers with pre-eclampsia', CLINICAL ENDOCRINOLOGY, 85 583-589 (2016)
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2016 White CRH, Doherty DA, Cannon JW, Kohan R, Newnham JP, Pennell CE, 'Cost effectiveness of universal umbilical cord blood gas and lactate analysis in a tertiary level maternity unit', JOURNAL OF PERINATAL MEDICINE, 44 573-584 (2016)
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2016 Le-Ha C, Herbison CE, Beilin LJ, Burrows S, Henley DE, Lye SJ, et al., 'Hypothalamic-pituitary-adrenal axis activity under resting conditions and cardiovascular risk factors in adolescents', PSYCHONEUROENDOCRINOLOGY, 66 118-124 (2016)
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2016 McVeigh JA, Zhu K, Mountain J, Pennell CE, Lye SJ, Walsh JP, Straker LM, 'Longitudinal Trajectories of Television Watching Across Childhood and Adolescence Predict Bone Mass at Age 20 Years in the Raine Study', JOURNAL OF BONE AND MINERAL RESEARCH, 31 2032-2040 (2016)
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2016 Middeldorp CM, Hammerschlag AR, Ouwens KG, Groen-Blokhuis MM, St Pourcain B, Greven CU, et al., 'A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts', JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 55 896-905 (2016)
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2016 Felix JF, Bradfield JP, Monnereau C, van der Valk RJP, Stergiakouli E, Chesi A, et al., 'Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index', HUMAN MOLECULAR GENETICS, 25 389-403 (2016)
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2016 Herbison CE, Henley D, Marsh J, Atkinson H, Newnham JP, Matthews SG, et al., 'Characterization and novel analyses of acute stress response patterns in a population-based cohort of young adults: influence of gender, smoking, and BMI', STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS, 19 139-150 (2016)
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2016 Shrine N, Tobin MD, Schurmann C, Artigas MS, Hui J, Lehtimaki T, et al., 'Genome-wide association study of copy number variation with lung function identifies a novel signal of association near BANP for forced vital capacity', BMC GENETICS, 17 (2016)
DOI 10.1186/s12863-016-0423-0
2016 White SW, Marsh JA, Lye SJ, Briollais L, Newnham JP, Pennell CE, 'Improving customized fetal biometry by longitudinal modelling', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 29 1888-1894 (2016)
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2016 Pappa I, St Pourcain B, Benke K, Cavadino A, Hakulinen C, Nivard MG, et al., 'A Genome-Wide Approach to Children's Aggressive Behavior: The EAGLE consortium', AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 171 562-572 (2016)
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2016 Heng YJ, Pennell CE, McDonald SW, Vinturache AE, Xu J, Lee MWF, et al., 'Maternal Whole Blood Gene Expression at 18 and 28 Weeks of Gestation Associated with Spontaneous Preterm Birth in Asymptomatic Women', PLOS ONE, 11 (2016)
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Citations Scopus - 12Web of Science - 11
2016 Demmer DL, Beilin LJ, Hands B, Burrows S, Pennell CE, Lye SJ, et al., 'Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the 'Gold Standard' Tarnished?', PLOS ONE, 11 (2016)
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Citations Scopus - 2Web of Science - 3
2016 Demmer DL, Beilin LJ, Hands B, Burrows S, Cox KL, Pennell CE, et al., 'Dual Energy X-Ray Absorptiometry Compared with Anthropometry in Relation to Cardio-Metabolic Risk Factors in a Young Adult Population: Is the 'Gold Standard' Tarnished? (vol 11, e0162164, 2016)', PLOS ONE, 11 (2016)
DOI 10.1371/journal.pone.0168961
2016 Unwin LM, Maybery MT, Murphy A, Lilje W, Bellesini M, Hunt AM, et al., 'A Prospective Ultrasound Study of Prenatal Growth in Infant Siblings of Children With Autism', AUTISM RESEARCH, 9 210-216 (2016)
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Citations Scopus - 4Web of Science - 4
2016 Parmar PG, Taal HR, Timpson NJ, Thiering E, Lehtimaki T, Marinelli M, et al., 'International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents', CIRCULATION-CARDIOVASCULAR GENETICS, 9 266-+ (2016)
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Citations Scopus - 18Web of Science - 18
2016 Rath SR, Marsh JA, Newnham JP, Zhu K, Atkinson HC, Mountain J, et al., 'Parental pre-pregnancy BMI is a dominant early-life risk factor influencing BMI of offspring in adulthood', OBESITY SCIENCE & PRACTICE, 2 48-57 (2016)
DOI 10.1002/osp4.28
Citations Web of Science - 9
2016 Zhu K, Henley D, Pennell C, Herbison CE, Mountain J, Lye S, Walsh JP, 'Associations between hypothalamic-pituitary-adrenal axis function and peak bone mass at 20 years of age in a birth cohort', BONE, 85 37-44 (2016)
DOI 10.1016/j.bone.2016.01.016
Citations Scopus - 2Web of Science - 2
2015 Pettigrew KA, Fajutrao Valles SF, Moll K, Northstone K, Ring S, Pennell C, et al., 'Lack of replication for the myosin-18B association with mathematical ability in independent cohorts', Genes, Brain and Behavior, 14 369-376 (2015)

© 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular lev... [more]

© 2015 The Authors. Twin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin-18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome-wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths-related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N=3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin-18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin-18B variant is unlikely to be a main factor contributing to mathematical abilities. We could not replicate the association of the myosin-18B gene with mathematical ability.

DOI 10.1111/gbb.12213
Citations Scopus - 6
2015 Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, et al., 'Corrigendum: Rare coding variants and X-linked loci associated with age at menarche', Nature Communications, 6 (2015)
DOI 10.1038/ncomms10257
Citations Scopus - 4
2015 Penova-Veselinovic B, Keelan JA, Wang CA, Newnham JP, Pennell CE, 'Changes in inflammatory mediators in gingival crevicular fluid following periodontal disease treatment in pregnancy: relationship to adverse pregnancy outcome', JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 112 1-10 (2015)
DOI 10.1016/j.jri.2015.05.002
Citations Scopus - 12Web of Science - 13
2015 Warrington NM, Howe LD, Paternoster L, Kaakinen M, Herrala S, Huikari V, et al., 'A genome-wide association study of body mass index across early life and childhood', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 44 700-712 (2015)
DOI 10.1093/ije/dyv077
Citations Scopus - 54Web of Science - 55
2015 van der Valk RJP, Kreiner-Moller E, Kooijman MN, Guxens M, Stergiakouli E, Saaf A, et al., 'A novel common variant in DCST2 is associated with length in early life and height in adulthood', HUMAN MOLECULAR GENETICS, 24 1155-1168 (2015)
DOI 10.1093/hmg/ddu510
Citations Scopus - 45Web of Science - 38
2015 Springelkamp H, Iglesias AI, Cuellar-Partida G, Amin N, Burdon KP, van Leeuwen EM, et al., 'ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure', HUMAN MOLECULAR GENETICS, 24 2689-2699 (2015)
DOI 10.1093/hmg/ddv027
Citations Scopus - 34Web of Science - 36
2015 Robinson M, Pennell CE, McLean NJ, Tearne JE, Oddy WH, Newnham JP, 'Risk Perception in Pregnancy lContext, Consequences, and Clinical Implications', EUROPEAN PSYCHOLOGIST, 20 120-127 (2015)
DOI 10.1027/1016-9040/a000212
Citations Scopus - 6Web of Science - 5
2015 Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP, et al., 'Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis', NATURE GENETICS, 47 1449-+ (2015)
DOI 10.1038/ng.3424
Citations Scopus - 170Web of Science - 165
2015 McKnight CM, Sherwin JC, Yazar S, Forward H, Tan AX, Hewitt AW, et al., 'Pterygium and conjunctival ultraviolet autofluorescence in young Australian adults: the Raine study', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 43 300-307 (2015)
DOI 10.1111/ceo.12455
Citations Scopus - 14Web of Science - 13
2015 Anderson D, Fakiola M, Hales BJ, Pennell CE, Thomas WR, Blackwell JM, 'Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniae', GENES AND IMMUNITY, 16 289-296 (2015)
DOI 10.1038/gene.2015.12
2015 Christiaens I, Ang QW, Gordon LN, Fang X, Williams SM, Pennell CE, Olson DM, 'Two novel genetic variants in the mineralocorticoid receptor gene associated with spontaneous preterm birth', BMC MEDICAL GENETICS, 16 (2015)
DOI 10.1186/s12881-015-0205-y
Citations Scopus - 4Web of Science - 4
2015 Paananen M, O'Sullivan P, Straker L, Beales D, Coenen P, Karppinen J, et al., 'A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: a longitudinal cohort study', ARTHRITIS RESEARCH & THERAPY, 17 (2015)
DOI 10.1186/s13075-015-0875-z
Citations Scopus - 17Web of Science - 15
2015 Heng YJ, Taylor L, Larsen BG, Chua HN, Pung SM, Lee MWF, et al., 'Albumin Decrease Is Associated with Spontaneous Preterm Delivery within 48 h in Women with Threatened Preterm Labor', JOURNAL OF PROTEOME RESEARCH, 14 457-466 (2015)
DOI 10.1021/pr500852p
Citations Scopus - 6Web of Science - 6
2015 Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, et al., 'Rare coding variants and X-linked loci associated with age at menarche', NATURE COMMUNICATIONS, 6 (2015)
DOI 10.1038/ncomms8756
Citations Scopus - 18Web of Science - 19
2015 Marenholz I, Esparza-Gordillo J, Rueschendorf F, Bauerfeind A, Strachan DP, Spycher BD, et al., 'Meta-analysis identifies seven susceptibility loci involved in the atopic march', NATURE COMMUNICATIONS, 6 (2015)
DOI 10.1038/ncomms9804
Citations Scopus - 56Web of Science - 57
2015 Yazar S, Cuellar-Partida G, McKnight CM, Quach-Thanissorn P, Mountain JA, Coroneo MT, et al., 'Genetic and Environmental Factors in Conjunctival UV Autofluorescence', JAMA OPHTHALMOLOGY, 133 406-412 (2015)
DOI 10.1001/jamaophthalmol.2014.5627
Citations Scopus - 10Web of Science - 10
2015 Cuellar-Partida G, Springelkamp H, Lucas SEM, Yazar S, Hewitt AW, Iglesias AI, et al., 'WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness', HUMAN MOLECULAR GENETICS, 24 5060-5068 (2015)
DOI 10.1093/hmg/ddv211
Citations Scopus - 22Web of Science - 21
2014 Hysi PG, Cheng C-Y, Springelkamp H, Macgregor S, Bailey JNC, Wojciechowski R, et al., 'Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma', NATURE GENETICS, 46 1126-1130 (2014)
DOI 10.1038/ng.3087
Citations Scopus - 105Web of Science - 107
Co-authors Liz Holliday, John Attia, Rodney Scott
2014 Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, et al., 'Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche', NATURE, 514 92-+ (2014)
DOI 10.1038/nature13545
Citations Scopus - 236Web of Science - 230
2014 Zhu K, Briffa K, Smith A, Mountain J, Briggs AM, Lye S, et al., 'Gender differences in the relationships between lean body mass, fat mass and peak bone mass in young adults', Osteoporosis International, 25 1563-1570 (2014)

Summary: The relationships between fat mass and bone mass in young adults are unclear. In 1,183 young Australians, lean body mass had a strong positive relationship with total bod... [more]

Summary: The relationships between fat mass and bone mass in young adults are unclear. In 1,183 young Australians, lean body mass had a strong positive relationship with total body bone mass in both genders. Fat mass was a positive predictor of total body bone mass in females, with weaker association in males. Introduction: Body weight and lean body mass are established as major determinants of bone mass, but the relationships between fat mass (including visceral fat) and peak bone mass in young adults are unclear. The aim of this study was to evaluate the associations between bone mass in young adults and three body composition measurements: lean body mass, fat mass and trunk-to-limb fat mass ratio (a surrogate measure of visceral fat). Methods: Study participants were 574 women and 609 men aged 19-22 years from the Raine study. Body composition, total body bone mineral content (TBBMC), bone area and areal bone mineral density (TBBMD) were measured using DXA. Results: In multivariate linear regression models with height, lean body mass, fat mass and trunk-to-limb fat mass ratio as predictor variables, lean mass was uniquely associated with the largest proportion of variance of TBBMC and TBBMD in males (semi-partial R 2 0.275 and 0.345, respectively) and TBBMC in females (semi-partial R 2 0.183). Fat mass was a more important predictor of TBBMC and TBBMD in females (semi-partial R 2 0.126 and 0.039, respectively) than males (semi-partial R 2 0.006 and 0.018, respectively). Trunk-to-limb fat mass ratio had a weak, negative association with TBBMC and bone area in both genders (semi-partial R 2 0.004 to 0.034). Conclusions: Lean body mass has strong positive relationship with total body bone mass in both genders. Fat mass may play a positive role in peak bone mass attainment in women but the association was weaker in men; different fat compartments may have different effects. © 2014 International Osteoporosis Foundation and National Osteoporosis Foundation.

DOI 10.1007/s00198-014-2665-x
Citations Scopus - 24
2014 Grace T, Bulsara M, Pennell C, Hands B, 'Maternal hypertensive diseases negatively affect offspring motor development', Pregnancy Hypertension, 4 209-214 (2014)

Objective Hypertension in pregnancy and preeclampsia have been linked to poor outcomes in cognitive, mental and psychomotor development; however, few longitudinal studies have res... [more]

Objective Hypertension in pregnancy and preeclampsia have been linked to poor outcomes in cognitive, mental and psychomotor development; however, few longitudinal studies have researched their effect on offspring motor development, particularly in late childhood and adolescence. The purpose of this study was to determine if maternal hypertensive diseases during pregnancy are a risk factor for compromised motor development at 10, 14, and 17 years. Study design Longitudinal cohort study using data from the Western Australian Pregnancy Cohort Study (Raine). Main outcome measure Offspring (n = 2868) were classified by their maternal blood pressure profiles during pregnancy: normotension (n = 2133), hypertension (n = 626) and preeclampsia (n = 109). Offspring motor development, at 10, 14, and 17 years was measured by the Neuromuscular Developmental Index (NDI) of the McCarron Assessment of Motor Development (MAND). Methods Linear mixed models were used to compare outcomes between pregnancy groups. Results Offspring from pregnancies complicated by preeclampsia had poorer motor outcomes at all ages than offspring from either normotensive mothers (p = 0.001) or those with hypertension (p = 0.002). Conclusion Hypertensive diseases during pregnancy, in particular preeclampsia, have long term and possibly permanent consequences for motor development of offspring. © 2014 International Society for the Study of Hypertension in Pregnancy Published by Elsevier B.V. All rights reserved.

DOI 10.1016/j.preghy.2014.04.003
Citations Scopus - 13
2014 Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion M-JA, et al., 'Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.', Mol Psychiatry, 19 253-258 (2014)
DOI 10.1038/mp.2012.184
Citations Scopus - 125
2014 St Pourcain B, Cents RAM, Whitehouse AJO, Haworth CMA, Davis OSP, O'Reilly PF, et al., 'Common variation near ROBO2 is associated with expressive vocabulary in infancy', Nature Communications, 5 (2014)

© 2014 Macmillan Publishers Limited. All rights reserved. Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this ... [more]

© 2014 Macmillan Publishers Limited. All rights reserved. Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the EArly Genetics and Lifecourse Epidemiology consortium, analysing an early (15-18 months, 'one-word stage', NTotal=8,889) and a later (24-30 months, 'two-word stage', NTotal=10,819) phase of language acquisition. For the early phase, one single-nucleotide polymorphism (rs7642482) at 3p12.3 near ROBO2, encoding a conserved axon-binding receptor, reaches the genome-wide significance level (P=1.3×10-8) in the combined sample. This association links language-related common genetic variation in the general population to a potential autism susceptibility locus and a linkage region for dyslexia, speech-sound disorder and reading. The contribution of common genetic influences is, although modest, supported by genome-wide complex trait analysis (meta-GCTA h15-18-months2=0.13, meta-GCTA h24-30-months2 =0.14) and in concordance with additional twin analysis (5,733 pairs of European descent, h24-months2=0.20).

DOI 10.1038/ncomms5831
Citations Scopus - 33
2014 Mcknight CM, Sherwin JC, Yazar S, Forward H, Tan AX, Hewitt AW, et al., 'Myopia in Young Adults Is Inversely Related to an Objective Marker of Ocular Sun Exposure: The Western Australian Raine Cohort Study', AMERICAN JOURNAL OF OPHTHALMOLOGY, 158 1079-1085 (2014)
DOI 10.1016/j.ajo.2014.07.033
Citations Scopus - 37Web of Science - 33
2014 White CRH, Doherty DA, Newnham JP, Pennell CE, 'The impact of introducing universal umbilical cord blood gas analysis and lactate measurement at delivery', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 54 71-78 (2014)
DOI 10.1111/ajo.12132
Citations Scopus - 12Web of Science - 11
2014 White CRH, Doherty DA, Newnham JP, Pennell CE, 'The Impact of Introducing Universal Umbilical Cord Blood Gas Analysis and Lactate Measurement at Delivery', OBSTETRICAL & GYNECOLOGICAL SURVEY, 69 307-308 (2014)
DOI 10.1097/OGX.0000000000000073
2014 Oddy WH, Mori TA, Huang R-C, Marsh JA, Pennell CE, Chivers PT, et al., 'Early Infant Feeding and Adiposity Risk: From Infancy to Adulthood', ANNALS OF NUTRITION AND METABOLISM, 64 262-270 (2014)
DOI 10.1159/000365031
Citations Scopus - 64Web of Science - 55
2014 Zhu K, Whitehouse AJO, Hart PH, Kusel M, Mountain J, Lye S, et al., 'Maternal Vitamin D Status During Pregnancy and Bone Mass in Offspring at 20 Years of Age: A Prospective Cohort Study', JOURNAL OF BONE AND MINERAL RESEARCH, 29 1088-1095 (2014)
DOI 10.1002/jbmr.2138
Citations Scopus - 65Web of Science - 57
2014 Benke KS, Nivard MG, Velders FP, Walters RK, Pappa I, Scheet PA, et al., 'A Genome-wide Association Meta-analysis of Preschool Internalizing Problems', JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 53 667-676 (2014)
DOI 10.1016/j.jaac.2013.12.028
Citations Scopus - 25Web of Science - 20
2014 Forward H, Yazar S, Hewitt AW, Khan J, Mountain JA, Pesudovs K, et al., 'Multiple prenatal ultrasound scans and ocular development: 20-year follow-up of a randomized controlled trial', ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 44 166-170 (2014)
DOI 10.1002/uog.13399
Citations Scopus - 5Web of Science - 4
2014 Perry JRB, Hsu Y-H, Chasman DI, Johnson AD, Elks C, Albrecht E, et al., 'DNA mismatch repair gene MSH6 implicated in determining age at natural menopause', HUMAN MOLECULAR GENETICS, 23 2490-2497 (2014)
DOI 10.1093/hmg/ddt620
Citations Scopus - 23Web of Science - 23
2014 Cousminer DL, Stergiakouli E, Berry DJ, Ang W, Groen-Blokhuis MM, Koerner A, et al., 'Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty', HUMAN MOLECULAR GENETICS, 23 4452-4464 (2014)
DOI 10.1093/hmg/ddu150
Citations Scopus - 41Web of Science - 45
2014 Hughes I, Harris M, Cotterill A, Garnett S, Bannink E, Pennell C, et al., 'Comparison of Centers for Disease Control and Prevention and World Health Organization references/standards for height in contemporary Australian children: Analyses of the Raine Study and Australian National Children's Nutrition and Physical Activity cohorts', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 50 895-901 (2014)
DOI 10.1111/jpc.12672
Citations Scopus - 5Web of Science - 7
2014 Anderson D, Holt BJ, Pennell CE, Holt PG, Hart PH, Blackwell JM, 'Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study', GENES AND IMMUNITY, 15 578-583 (2014)
DOI 10.1038/gene.2014.52
Citations Scopus - 24Web of Science - 19
2014 Hart R, Doherty DA, Frederiksen H, Keelan JA, Hickey M, Sloboda D, et al., 'The influence of antenatal exposure to phthalates on subsequent female reproductive development in adolescence: a pilot study', REPRODUCTION, 147 379-390 (2014)
DOI 10.1530/REP-13-0331
Citations Scopus - 36Web of Science - 35
2014 Rye MS, Scaman ESH, Thornton RB, Vijayasekaran S, Coates HL, Francis RW, et al., 'Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3', BMC MEDICAL GENETICS, 15 (2014)
DOI 10.1186/1471-2350-15-18
Citations Scopus - 5Web of Science - 6
2014 Bolton JL, Hayward C, Direk N, Lewis JG, Hammond GL, Hill LA, et al., 'Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin', PLOS GENETICS, 10 (2014)
DOI 10.1371/journal.pgen.1004474
Citations Scopus - 51Web of Science - 48
2014 Newnham JP, Dickinson JE, Hart RJ, Pennell CE, Arrese CA, Keelan JA, 'Strategies to prevent preterm birth', FRONTIERS IN IMMUNOLOGY, 5 (2014)
DOI 10.3389/fimmu.2014.00584
Citations Scopus - 38Web of Science - 33
2014 Anderson LN, Briollais L, Atkinson HC, Marsh JA, Xu J, Connor KL, et al., 'Investigation of Genetic Variants, Birthweight and Hypothalamic- Pituitary- Adrenal Axis Function Suggests a Genetic Variant in the SERPINA6 Gene Is Associated with Corticosteroid Binding Globulin in the Western Australia Pregnancy Cohort ( Raine) Study', PLOS ONE, 9 (2014)
DOI 10.1371/journal.pone.0092957
Citations Scopus - 5Web of Science - 4
2014 Heng YJ, Pennell CE, Chua HN, Perkins JE, Lye SJ, 'Whole Blood Gene Expression Profile Associated with Spontaneous Preterm Birth in Women with Threatened Preterm Labor', PLOS ONE, 9 (2014)
DOI 10.1371/journal.pone.0096901
Citations Scopus - 26Web of Science - 26
2014 Warrington NM, Tilling K, Howe LD, Paternoster L, Pennell CE, Wu YY, Briollais L, 'Robustness of the linear mixed effects model to error distribution assumptions and the consequences for genome-wide association studies', STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, 13 567-587 (2014)
DOI 10.1515/sagmb-2013-0066
Citations Scopus - 7Web of Science - 6
2014 Loset M, Johnson MP, Melton PE, Ang W, Huang R-C, Mori TA, et al., 'Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22', PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 4 178-185 (2014)
DOI 10.1016/j.preghy.2014.03.005
Citations Scopus - 8Web of Science - 6
2014 Ferreira MAR, Matheson MC, Tang CS, Granell R, Ang W, Hui J, et al., 'Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 133 1564-1571 (2014)
DOI 10.1016/j.jaci.2013.10.030
Citations Scopus - 98Web of Science - 93
2013 Kamara M, Henderson JJ, Doherty DA, Dickinson JE, Pennell CE, 'The risk of placenta accreta following primary elective caesarean delivery: A case-control study', Obstetrical and Gynecological Survey, 68 729-730 (2013)
DOI 10.1097/OGX.0000000000000015
2013 Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, et al., 'Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference (Nature Genetics (2012) 44 (532-538))', Nature Genetics, 45 713 (2013)
DOI 10.1038/ng0613-713a
Citations Scopus - 2
2013 Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, et al., 'Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume (Nature Genetics (2012) 44 (539-544))', Nature Genetics, 45 713 (2013)
DOI 10.1038/ng0613-713c
2013 Verhoeven VJM, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Höhn R, et al., 'Erratum: Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia (Nature Genetics (2013) 45 (314-318))', Nature Genetics, 45 712 (2013)
DOI 10.1038/ng0613-712b
Citations Scopus - 4
2013 Kamara M, Henderson JJ, Doherty DA, Dickinson JE, Pennell CE, 'The risk of placenta accreta following primary elective caesarean delivery: A case-control study', BJOG: An International Journal of Obstetrics and Gynaecology, 120 879-886 (2013)

Objective To evaluate the risk of placenta praevia accreta following primary (first) elective or primary emergency caesarean section in a pregnancy complicated by placenta praevia... [more]

Objective To evaluate the risk of placenta praevia accreta following primary (first) elective or primary emergency caesarean section in a pregnancy complicated by placenta praevia. Design Retrospective matched case-control study, employing variable matching. Setting Tertiary referral centre between 1993 and 2008. Population Sixty-five cases and 102 controls were used for the analysis from a total of 82 667 births during the study period. Methods Relevant data were abstracted from clinical records. Matching of cases with controls was based on co-existing placenta praevia, number of previous caesarean sections, and age, with one or two controls per case. Results are presented as odds ratios (ORs) with 95% confidence intervals (95% CIs). Main outcome measures Placenta accreta in a pregnancy complicated by placenta praevia following a primary elective or emergency caesarean section, and morbidity associated with pregnancies complicated by placenta accreta. Results Significantly more cases than controls had an elective caesarean section for their primary caesarean delivery (46.2 versus 18.6%; P < 0.001). There were no differences between groups for previous pregnancy loss, uterine surgery, and vaginal delivery, before or after the primary caesarean section. Compared with primary emergency caesarean section, primary elective caesarean section significantly increased the risk of placenta accreta in a subsequent pregnancy in the presence of placenta praevia (OR 3.00; 95% CI 1.47-6.12; P = 0.025). Conclusions Our results suggest that women with a primary elective caesarean section without labour are more likely, compared with those undergoing primary emergency caesarean section with labour, to develop an accreta in a subsequent pregnancy with placenta praevia. © 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.

DOI 10.1111/1471-0528.12148
Citations Scopus - 23
2013 Hammond G, Langridge A, Leonard H, Hagan R, Jacoby P, DeKlerk N, et al., 'Changes in risk factors for preterm birth in Western Australia 1984-2006.', BJOG, 120 1051-1060 (2013)
DOI 10.1111/1471-0528.12188
Citations Scopus - 17
2013 Fernandez-Rhodes L, Demerath EW, Cousminer DL, Tao R, Dreyfus JG, Esko T, et al., 'Association of Adiposity Genetic Variants With Menarche Timing in 92,105 Women of European Descent', AMERICAN JOURNAL OF EPIDEMIOLOGY, 178 451-460 (2013)
DOI 10.1093/aje/kws473
Citations Scopus - 31Web of Science - 32
2013 Cheng C-Y, Schache M, Ikram MK, Young TL, Guggenheim JA, Vitart V, et al., 'Nine Loci for Ocular Axial Length Identified through Genome-wide Association Studies, Including Shared Loci with Refractive Error', AMERICAN JOURNAL OF HUMAN GENETICS, 93 264-277 (2013)
DOI 10.1016/j.ajhg.2013.06.016
Citations Scopus - 71Web of Science - 65
2013 Robinson M, Whitehouse AJO, Zubrick SR, Pennell CE, Jacoby P, Mclean NJ, et al., 'Delivery at 37weeks' gestation is associated with a higher risk for child behavioural problems', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 53 143-151 (2013)
DOI 10.1111/ajo.12012
Citations Scopus - 14Web of Science - 13
2013 White CRH, Kohan R, Doherty DA, Newnham JP, Pennell CE, 'Attitudes and barriers to the introduction of umbilical cord blood gas and lactate analysis at birth', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 53 271-276 (2013)
DOI 10.1111/ajo.12058
Citations Scopus - 2Web of Science - 2
2013 Robinson M, Oddy WH, Whitehouse AJO, Pennell CE, Kendall GE, McLean NJ, et al., 'Hypertensive Diseases of Pregnancy Predict Parent-Reported Difficult Temperament in Infancy', JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, 34 174-180 (2013)
DOI 10.1097/DBP.0b013e31827d5761
Citations Scopus - 10Web of Science - 9
2013 Adams LA, White SW, Marsh JA, Lye SJ, Connor KL, Maganga R, et al., 'Association Between Liver-Specific Gene Polymorphisms and Their Expression Levels With Nonalcoholic Fatty Liver Disease', HEPATOLOGY, 57 590-600 (2013)
DOI 10.1002/hep.26184
Citations Scopus - 50Web of Science - 47
2013 Pennell CE, Vadillo-Ortega F, Olson DM, Ha E-H, Williams S, Frayling TM, et al., 'Preterm Birth Genome Project (PGP) - validation of resources for preterm birth genome-wide studies', JOURNAL OF PERINATAL MEDICINE, 41 45-49 (2013)
DOI 10.1515/jpm-2012-0145
Citations Scopus - 8Web of Science - 7
2013 Reynolds RM, Hii HL, Pennell CE, McKeague IW, de Kloet ER, Lye S, et al., 'Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis', PSYCHONEUROENDOCRINOLOGY, 38 1271-1280 (2013)
DOI 10.1016/j.psyneuen.2012.11.010
Citations Web of Science - 18
2013 Reynolds RM, Hii HL, Pennell CE, McKeague IW, Kloet ERD, Lye S, et al., 'Analysis of baseline hypothalamic-pituitary-adrenal activity in late adolescence reveals gender specific sensitivity of the stress axis', Psychoneuroendocrinology, 38 1271-1280 (2013)

Dysfunctional regulation of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an important biological mechanism underlying stress-related diseases; however, a bet... [more]

Dysfunctional regulation of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an important biological mechanism underlying stress-related diseases; however, a better understanding of the interlinked neuroendocrine events driving the release of cortisol by this stress axis is essential for progress in preventing or halting irreversible development of adverse HPA-function. We aimed to investigate basal HPA-activity in a normal population in late adolescence, the time of life believed to overlap with HPA-axis maturation and establishment of a lasting set point level of HPA function. A total of 1258 participants (mean age 16.6 years) recruited from the Western Australian Pregnancy (Raine) Cohort provided fasting morning blood and saliva samples for basal HPA activity assessment. Irrespective of gender, linear regression modelling identified a positive correlation between the main components of the HPA-cascade of events, ACTH, total cortisol and free cortisol in saliva. Corticosteroid binding globulin (CBG) was inversely associated with free cortisol in saliva, an effect most clearly observed in boys. ACTH levels were lower, but cortisol levels were higher in girls than in boys. Girls may also be exposed to more bioactive cortisol, based on higher average free cortisol measured in saliva at awakening. These relatively higher female free cortisol levels were significantly reduced by oral contraceptive use, eliminating the gender specific difference in salivary cortisol. Free plasma cortisol, calculated from total circulating cortisol and CBG concentrations, was also significantly reduced in girls using oral contraceptives, possibly via an enhancing effect of oral contraceptives on blood CBG content. This study highlights a clear gender difference in HPA activity under non-stressful natural conditions. This finding may be relevant for research into sex-specific stress-related diseases with a typical onset in late adolescence. © 2012 Elsevier Ltd.

DOI 10.1016/j.psyneuen.2012.11.010
Citations Scopus - 19
2013 Cousminer DL, Berry DJ, Timpson NJ, Ang W, Thiering E, Byrne EM, et al., 'Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity', HUMAN MOLECULAR GENETICS, 22 2735-2747 (2013)
DOI 10.1093/hmg/ddt104
Citations Scopus - 90Web of Science - 84
2013 Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, et al., 'New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism', NATURE GENETICS, 45 76-U115 (2013)
DOI 10.1038/ng.2477
Citations Scopus - 160Web of Science - 159
2013 Lu Y, Vitart V, Burdon KP, Khor CC, Bykhovskaya Y, Mirshahi A, et al., 'Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus', NATURE GENETICS, 45 155-163 (2013)
DOI 10.1038/ng.2506
Citations Scopus - 147Web of Science - 156
2013 Verhoeven VJM, Hysi PG, Wojciechowski R, Fan Q, Guggenheim JA, Hoehn R, et al., 'Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia', NATURE GENETICS, 45 314-318 (2013)
DOI 10.1038/ng.2554
Citations Scopus - 214Web of Science - 212
2013 Bonnelykke K, Matheson MC, Pers TH, Granell R, Strachan DP, Alves AC, et al., 'Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization', NATURE GENETICS, 45 902-U290 (2013)
DOI 10.1038/ng.2694
Citations Scopus - 139Web of Science - 139
2013 Yazar S, Mishra A, Ang W, Kearns LS, Mountain JA, Pennell C, et al., 'Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: Results of a genome-wide association study', MOLECULAR VISION, 19 1238-1246 (2013)
Citations Scopus - 6Web of Science - 5
2013 Yazar S, Forward H, McKnight CM, Tan A, Soloshenko A, Oates SK, et al., 'Raine Eye Health Study: Design, Methodology and Baseline Prevalence of Ophthalmic Disease in a Birth-cohort Study of Young Adults', OPHTHALMIC GENETICS, 34 199-208 (2013)
DOI 10.3109/13816810.2012.755632
Citations Scopus - 18Web of Science - 13
2013 McDonald SW, Lyon AW, Benzies KM, McNeil DA, Lye SJ, Dolan SM, et al., 'The All Our Babies pregnancy cohort: design, methods, and participant characteristics', BMC PREGNANCY AND CHILDBIRTH, 13 (2013)
DOI 10.1186/1471-2393-13-S1-S2
Citations Scopus - 66Web of Science - 75
2013 Moeller MIP, Henderson JJ, Nathan EA, Pennell CE, 'Cervilenz (TM) is an effective tool for screening cervical-length in comparison to transvaginal ultrasound', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 26 378-382 (2013)
DOI 10.3109/14767058.2012.712564
Citations Scopus - 4Web of Science - 3
2013 Davidoff DF, Dickinson JE, Warner T, Pennell CE, 'Twin-Twin Transfusion Syndrome and Twin Anemia-Polycythemia Sequence in a Monochorionic Triamniotic Pregnancy', TWIN RESEARCH AND HUMAN GENETICS, 16 716-719 (2013)
DOI 10.1017/thg.2013.13
Citations Scopus - 3Web of Science - 3
2013 Langridge AT, Glasson EJ, Nassar N, Jacoby P, Pennell C, Hagan R, et al., 'Maternal Conditions and Perinatal Characteristics Associated with Autism Spectrum Disorder and Intellectual Disability', PLOS ONE, 8 (2013)
DOI 10.1371/journal.pone.0050963
Citations Scopus - 62Web of Science - 57
2013 Warrington NM, Wu YY, Pennell CE, Marsh JA, Beilin LJ, Palmer LJ, et al., 'Modelling BMI Trajectories in Children for Genetic Association Studies', PLOS ONE, 8 (2013)
DOI 10.1371/journal.pone.0053897
Citations Scopus - 20Web of Science - 20
2013 Warrington NM, Howe LD, Wu YY, Timpson NJ, Tilling K, Pennell CE, et al., 'Association of a Body Mass Index Genetic Risk Score with Growth throughout Childhood and Adolescence', PLOS ONE, 8 (2013)
DOI 10.1371/journal.pone.0079547
Citations Scopus - 30Web of Science - 34
2013 Howe LD, Parmar PG, Paternoster L, Warrington NM, Kemp JP, Briollais L, et al., 'Genetic Influences on Trajectories of Systolic Blood Pressure Across Childhood and Adolescence', CIRCULATION-CARDIOVASCULAR GENETICS, 6 608-614 (2013)
DOI 10.1161/CIRCGENETICS.113.000197
Citations Scopus - 13Web of Science - 14
2013 Robinson M, Zubrick SR, Pennell CE, Van Lieshout RJ, Jacoby P, Beilin LJ, et al., 'Pre-pregnancy maternal overweight and obesity increase the risk for affective disorders in offspring', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 4 42-48 (2013)
DOI 10.1017/S2040174412000578
Citations Scopus - 23Web of Science - 24
2013 Parmar PG, Marsh JA, Taal HR, Kowgier M, Uitterlinden AG, Rivadeneira F, et al., 'Polymorphisms in genes within the IGF-axis influence antenatal and postnatal growth', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 4 157-169 (2013)
DOI 10.1017/S2040174412000633
Citations Scopus - 1Web of Science - 1
2013 St Pourcain B, Whitehouse AJO, Ang WQ, Warrington NM, Glessner JT, Wang K, et al., 'Common variation contributes to the genetic architecture of social communication traits', MOLECULAR AUTISM, 4 (2013)
DOI 10.1186/2040-2392-4-34
Citations Scopus - 25Web of Science - 25
2012 Taal HR, St Pourcain B, Thiering E, Das S, Mook-Kanamori DO, Warrington NM, et al., 'Common variants at 12q15 and 12q24 are associated with infant head circumference', NATURE GENETICS, 44 532-+ (2012)
DOI 10.1038/ng.2238
Citations Scopus - 73Web of Science - 74
2012 Ikram MA, Fornage M, Smith AV, Seshadri S, Schmidt R, Debette S, et al., 'Common variants at 6q22 and 17q21 are associated with intracranial volume', NATURE GENETICS, 44 539-+ (2012)
DOI 10.1038/ng.2245
Citations Scopus - 76Web of Science - 84
2012 McKnight CM, Newnham JP, Stanley FJ, Mountain JA, Landau LI, Beilin LJ, et al., 'Birth of a cohort The first 20 years of the raine study', Medical Journal of Australia, 197 608-610 (2012)
DOI 10.5694/mja12.10698
Citations Scopus - 31
2012 Robinson M, Mattes E, Oddy WH, Pennell CE, Van Eekelen A, Mclean NJ, et al., 'Erratum: Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events (Development and Psychopathology (2011) 23 (507-520))', Development and Psychopathology, 24 (2012)
DOI 10.1017/S0954579411000861
2012 Whitehouse AJO, Bishop DVM, Ang QW, Pennell CE, Fisher SE, 'CNTNAP2 variants affect early language development in the general population', Genes, Brain and Behavior, 11 501 (2012)
DOI 10.1111/j.1601-183X.2012.00806.x
Citations Scopus - 3
2012 Johnson M, Løset M, Brennecke S, Peralta J, Dyer T, East C, et al., 'OS049. Exome sequencing identifies likely functional variantsinfluencing preeclampsia and CVD risk.', Pregnancy hypertension, 2 203-204 (2012)
DOI 10.1016/j.preghy.2012.04.050
2012 Løset M, Johnson MP, Pennell C, Huang R-C, Mori T, Beilin L, et al., 'OS070. Shared genetic risk factors for preeclampsia and cardiovascular disease.', Pregnancy hypertension, 2 214-215 (2012)
DOI 10.1016/j.preghy.2012.04.071
2012 Bonilla C, Lawlor DA, Taylor AE, Gunnell DJ, Ben-Shlomo Y, Ness AR, et al., 'Vitamin B-12 Status during Pregnancy and Child's IQ at Age 8: A Mendelian Randomization Study in the Avon Longitudinal Study of Parents and Children', PLoS ONE, 7 (2012)

Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal ... [more]

Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC). We then examined the association of SNPs in maternal genes FUT2 (rs492602) and TCN2 (rs1801198, rs9606756) that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child's IQ that was markedly attenuated after adjustment for potential confounders (mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 (95% CI 1.3, 2.8); after adjustment: 0.7 (95% CI -0.04, 1.4)). Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 (95% CI 0.1, 1.6). The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted. © 2012 Bonilla et al.

DOI 10.1371/journal.pone.0051084
Citations Scopus - 16
2012 Webb TR, Matarin M, Gardner JC, Kelberman D, Hassan H, Ang W, et al., 'X-Linked Megalocornea Caused by Mutations in CHRDL1 Identifies an Essential Role for Ventroptin in Anterior Segment Development', AMERICAN JOURNAL OF HUMAN GENETICS, 90 247-259 (2012)
DOI 10.1016/j.ajhg.2011.12.019
Citations Scopus - 18Web of Science - 18
2012 Paternoster L, Standl M, Chen C-M, Ramasamy A, Bonnelykke K, Duijts L, et al., 'Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis', NATURE GENETICS, 44 187-192 (2012)
DOI 10.1038/ng.1017
Citations Scopus - 197Web of Science - 186
2012 Bradfield JP, Taal HR, Timpson NJ, Scherag A, Lecoeur C, Warrington NM, et al., 'A genome-wide association meta-analysis identifies new childhood obesity loci', NATURE GENETICS, 44 526-+ (2012)
DOI 10.1038/ng.2247
Citations Scopus - 212Web of Science - 203
2012 Skouen JS, Smith AJ, Warrington NM, O' Sullivan PB, McKenzie L, Pennell CE, Straker LM, 'Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents', EUROPEAN JOURNAL OF PAIN, 16 1232-1242 (2012)
DOI 10.1002/j.1532-2149.2012.00131.x
Citations Web of Science - 17
2012 White CRH, Doherty DA, Kohan R, Newnham JP, Pennell CE, 'Evaluation of selection criteria for validating paired umbilical cord blood gas samples: an observational study', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 119 857-865 (2012)
DOI 10.1111/j.1471-0528.2012.03308.x
Citations Scopus - 7Web of Science - 8
2012 White CRH, Mok T, Doherty DA, Henderson JJ, Newnham JP, Pennell CE, 'The effect of time, temperature and storage device on umbilical cord blood gas and lactate measurement: a randomized controlled trial', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 587-594 (2012)
DOI 10.3109/14767058.2011.596959
Citations Scopus - 4Web of Science - 6
2012 Henderson JJ, McWilliam OA, Newnham JP, Pennell CE, 'Preterm birth aetiology 2004-2008. Maternal factors associated with three phenotypes: spontaneous preterm labour, preterm pre-labour rupture of membranes and medically indicated preterm birth', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 642-647 (2012)
DOI 10.3109/14767058.2011.597899
Citations Scopus - 53Web of Science - 46
2012 White CRH, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE, 'Accurate prediction of hypoxic-ischaemic encephalopathy at delivery: a cohort study', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 1653-1659 (2012)
DOI 10.3109/14767058.2011.653421
Citations Scopus - 21Web of Science - 19
2012 Hunter TJ, Byrnes MJ, Nathan E, Gill A, Pennell CE, 'Factors influencing survival in pre-viable preterm premature rupture of membranes', JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 25 1755-1761 (2012)
DOI 10.3109/14767058.2012.663824
Citations Scopus - 16Web of Science - 14
2012 Huang R-C, Galati JC, Burrows S, Beilin LJ, Li X, Pennell CE, et al., 'DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults', CLINICAL EPIGENETICS, 4 (2012)
DOI 10.1186/1868-7083-4-21
Citations Web of Science - 46
2012 Boraska V, Day-Williams A, Franklin CS, Elliott KS, Panoutsopoulou K, Tachmazidou I, et al., 'Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts', PLOS ONE, 7 (2012)
DOI 10.1371/journal.pone.0031369
Citations Scopus - 2Web of Science - 3
2012 Rye MS, Warrington NM, Scaman ESH, Vijayasekaran S, Coates HL, Anderson D, et al., 'Genome-Wide Association Study to Identify the Genetic Determinants of Otitis Media Susceptibility in Childhood', PLOS ONE, 7 (2012)
DOI 10.1371/journal.pone.0048215
Citations Scopus - 35Web of Science - 36
2012 Scerri TS, Darki F, Newbury DF, Whitehouse AJO, Peyrard-Janvid M, Matsson H, et al., 'The Dyslexia Candidate Locus on 2p12 Is Associated with General Cognitive Ability and White Matter Structure', PLOS ONE, 7 (2012)
DOI 10.1371/journal.pone.0050321
Citations Scopus - 29Web of Science - 25
2012 Marsh JA, Pennell CE, Warrington NM, Mook-Kanamori D, Briollais L, Lye SJ, et al., 'Fat mass and obesity-associated obesity-risk genotype is associated with lower foetal growth: an effect that is reversed in the offspring of smoking mothers', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 3 10-20 (2012)
DOI 10.1017/S2040174411000638
Citations Scopus - 6Web of Science - 6
2012 Meyerkort CE, Oddy WH, O'Sullivan TA, Henderson J, Pennell CE, 'Early diet quality in a longitudinal study of Australian children: associations with nutrition and body mass index later in childhood and adolescence', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 3 21-31 (2012)
DOI 10.1017/S2040174411000717
Citations Scopus - 14Web of Science - 14
2012 Boraska V, Jeroncic A, Colonna V, Southam L, Nyholt DR, Rayner NW, et al., 'Genome-wide meta-analysis of common variant differences between men and women', HUMAN MOLECULAR GENETICS, 21 4805-4815 (2012)
DOI 10.1093/hmg/dds304
Citations Scopus - 13Web of Science - 14
2012 McKnight CM, Newnham JP, Stanley FJ, Mountain JA, Landau LI, Beilin LJ, et al., 'Birth of a cohort - the first 20 years of the Raine study', MEDICAL JOURNAL OF AUSTRALIA, 197 608-610 (2012)
DOI 10.5694/mja12.10698
Citations Web of Science - 30
2012 Van Eekelen JAM, Ellis JA, Pennell CE, Craig J, Saffery R, Mattes E, Olsson CA, 'Stress-sensitive neurosignalling in depression: An integrated network biology approach to candidate gene selection for genetic association analysis', Mental Illness, 4 105-114 (2012)

© J.A.M. van Eekelen et al., 2012. Genetic risk for depressive disorders is poorly understood despite consistent suggestions of a high heritable component. Most genetic studies ha... [more]

© J.A.M. van Eekelen et al., 2012. Genetic risk for depressive disorders is poorly understood despite consistent suggestions of a high heritable component. Most genetic studies have focused on risk associated with single variants, a strategy which has so far only yielded small (often non-replicable) risks for depressive disorders. In this paper we argue that more substantial risks are likely to emerge from genetic variants acting in synergy within and across larger neurobiological systems (polygenic risk factors). We show how knowledge of major integrated neurobiological systems provides a robust basis for defining and testing theoretically defensible polygenic risk factors. We do this by describing the architecture of the overall stress response. Maladaptation via impaired stress responsiveness is central to the aetiology of depression and anxiety and provides a framework for a systems biology approach to candidate gene selection. We propose principles for identifying genes and gene networks within the neurosystems involved in the stress response and for defining polygenic risk factors based on the neurobiology of stressrelated behaviour. We conclude that knowledge of the neurobiology of the stress response system is likely to play a central role in future efforts to improve genetic prediction of depression and related disorders.

DOI 10.4081/mi.2012.e21
Citations Scopus - 2
2012 Myatt L, Eschenbach DA, Lye SJ, Mesiano S, Murtha AP, Williams SM, Pennell CE, 'A Standardized Template for Clinical Studies in Preterm Birth', REPRODUCTIVE SCIENCES, 19 474-482 (2012)
DOI 10.1177/1933719111426602
Citations Scopus - 17Web of Science - 17
2012 Mishra A, Yazar S, Hewitt AW, Mountain JA, Ang W, Pennell CE, et al., 'Genetic Variants near PDGFRA Are Associated with Corneal Curvature in Australians', INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 53 7131-7136 (2012)
DOI 10.1167/iovs.12-10489
Citations Scopus - 20Web of Science - 19
2012 Hart R, Doherty DA, Pennell CE, Newnham IA, Newnham JP, 'Periodontal disease: a potential modifiable risk factor limiting conception', HUMAN REPRODUCTION, 27 1332-1342 (2012)
DOI 10.1093/humrep/des034
Citations Scopus - 15Web of Science - 14
2012 Whitehouse AJO, Robinson M, Newnham JP, Pennell CE, 'Do hypertensive diseases of pregnancy disrupt neurocognitive development in offspring?', PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 26 101-108 (2012)
DOI 10.1111/j.1365-3016.2011.01257.x
Citations Scopus - 43Web of Science - 42
2012 Mackey DA, Warrington NM, Hewitt AW, Oates SK, Yazar S, Soloshenko A, et al., 'Role of the TCF4 Gene Intronic Variant in Normal Variation of Corneal Endothelium', CORNEA, 31 162-166 (2012)
DOI 10.1097/ICO.0b013e318226155f
Citations Scopus - 7Web of Science - 7
2012 Abarin T, Wu YY, Warrington N, Lye S, Pennell C, Briollais L, 'The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 41 1650-1660 (2012)
DOI 10.1093/ije/dys171
Citations Scopus - 21Web of Science - 17
2012 Adams LA, Marsh JA, Ayonrinde OT, Olynyk JK, Ang WQ, Beilin LJ, et al., 'Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposity', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 27 1520-1527 (2012)
DOI 10.1111/j.1440-1746.2012.07120.x
Citations Scopus - 16Web of Science - 15
2012 Middelberg RP, Benyamin B, de Moor MHM, Warrington NM, Gordon S, Henders AK, et al., 'Loci affecting gamma-glutamyl transferase in adults and adolescents show age x SNP interaction and cardiometabolic disease associations', HUMAN MOLECULAR GENETICS, 21 446-455 (2012)
DOI 10.1093/hmg/ddr478
Citations Scopus - 20Web of Science - 18
2012 Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion M-JA, et al., 'Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5CHRNA3CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight', HUMAN MOLECULAR GENETICS, 21 5344-5358 (2012)
DOI 10.1093/hmg/dds372
Citations Scopus - 41Web of Science - 41
2011 Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, et al., 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function', NATURE GENETICS, 43 1082-1090 (2011)
DOI 10.1038/ng.941
Citations Scopus - 254Web of Science - 226
2011 White CRH, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE, 'Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit', Obstetrical and Gynecological Survey, 66 14-15 (2011)
DOI 10.1097/OGX.0b013e3182021f9c
2011 Pennell CE, Henderson JJ, O'Neill MJ, McCleery S, Doherty DA, Dickinson JE, 'Erratum: Induction of labour in nulliparous women with an unfavourable cervix: a randomised controlled trial comparing double and single balloon catheters and PGE
DOI 10.1111/j.1471-0528.2011.02919.x
2011 Henderson JJ, Pennell CE, Dickinson JE, 'Transcervical Foley catheter should be used in preference to intravaginal prostaglandins for induction of labor with an unfavorable cervix', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 205 E19-E20 (2011)
DOI 10.1016/j.ajog.2011.01.010
Citations Scopus - 4Web of Science - 4
2011 van Eekelen JAM, Olsson CA, Ellis JA, Ang W, Hutchinson D, Zubrick SR, Pennell CE, 'Identification and genetic determination of an early life risk disposition for depressive disorder: Atypical stress-related behaviour in early childhood', AUSTRALIAN JOURNAL OF PSYCHOLOGY, 63 6-17 (2011)
DOI 10.1111/j.1742-9536.2011.00002.x
Citations Scopus - 8Web of Science - 8
2011 Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, et al., 'Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children', DIABETES, 60 1805-1812 (2011)
DOI 10.2337/db10-1575
Citations Scopus - 66Web of Science - 64
2011 Mook-Kanamori DO, Marsh JA, Warrington NM, Taal HR, Newnham JP, Beilin LJ, et al., 'Variants near CCNL1/LEKR1 and in ADCY5 and Fetal Growth Characteristics in Different Trimesters', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 96 E810-E815 (2011)
DOI 10.1210/jc.2010-2316
Citations Scopus - 16Web of Science - 15
2011 Whitehouse AJO, Hickey M, Stanley FJ, Newnham JP, Pennell CE, 'Brief Report: A Preliminary Study of Fetal Head Circumference Growth in Autism Spectrum Disorder', JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 41 122-129 (2011)
DOI 10.1007/s10803-010-1019-6
Citations Scopus - 24Web of Science - 24
2011 Robinson M, Pennell CE, McLean NJ, Oddy WH, Newnham JP, 'The over-estimation of risk in pregnancy', JOURNAL OF PSYCHOSOMATIC OBSTETRICS AND GYNECOLOGY, 32 53-58 (2011)
DOI 10.3109/0167482X.2011.569099
Citations Scopus - 9Web of Science - 8
2011 Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Pennell CE, de Klerk N, et al., 'Gender-Specific Differences in Adipose Distribution and Adipocytokines Influence Adolescent Nonalcoholic Fatty Liver Disease', HEPATOLOGY, 53 800-809 (2011)
DOI 10.1002/hep.24097
Citations Scopus - 120Web of Science - 115
2011 Robinson M, Mattes E, Oddy WH, Pennell CE, van Eekelen A, McLean NJ, et al., 'Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: The influence of the number, type, and timing of stressful life events', DEVELOPMENT AND PSYCHOPATHOLOGY, 23 507-520 (2011)
DOI 10.1017/S0954579411000241
Citations Scopus - 49Web of Science - 47
2011 Rye MS, Wiertsema SP, Scaman ESH, Oommen J, Sun W, Francis RW, et al., 'FBXO11, a regulator of the TGF beta pathway, is associated with severe otitis media in Western Australian children', GENES AND IMMUNITY, 12 352-359 (2011)
DOI 10.1038/gene.2011.2
Citations Scopus - 31Web of Science - 32
2011 Gracie S, Pennell C, Ekman-Ordeberg G, Lye S, McManaman J, Williams S, et al., 'An integrated systems biology approach to the study of preterm birth using "-omic" technology - a guideline for research', BMC PREGNANCY AND CHILDBIRTH, 11 (2011)
DOI 10.1186/1471-2393-11-71
Citations Scopus - 37Web of Science - 31
2011 Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, Palmer CNA, et al., 'Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development', PLOS GENETICS, 7 (2011)
DOI 10.1371/journal.pgen.1001307
Citations Scopus - 118Web of Science - 110
2011 Paracchini S, Ang QW, Stanley FJ, Monaco AP, Pennell CE, Whitehouse AJO, 'Analysis of dyslexia candidate genes in the Raine cohort representing the general Australian population', GENES BRAIN AND BEHAVIOR, 10 158-165 (2011)
DOI 10.1111/j.1601-183X.2010.00651.x
Citations Scopus - 42Web of Science - 42
2011 Whitehouse AJO, Bishop DVM, Ang QW, Pennell CE, Fisher SE, 'CNTNAP2 variants affect early language development in the general population', GENES BRAIN AND BEHAVIOR, 10 451-456 (2011)
DOI 10.1111/j.1601-183X.2011.00684.x
Citations Scopus - 100Web of Science - 93
2011 Ronald A, Pennell CE, Whitehouse AJO, 'Prenatal maternal stress associated with ADHD and autistic traits in early childhood', FRONTIERS IN PSYCHOLOGY, 2 (2011)
DOI 10.3389/fpsyg.2010.00223
Citations Scopus - 122Web of Science - 110
2011 Ferreira MAR, Matheson MC, Duffy DL, Marks GB, Hui J, Le Souef P, et al., 'Identification of IL6R and chromosome 11q13.5 as risk loci for asthma', LANCET, 378 1006-1014 (2011)
DOI 10.1016/S0140-6736(11)60874-X
Citations Scopus - 232Web of Science - 229
2010 Pennell CE, Henderson JJ, O'Neill MJ, McCleery S, Doherty DA, Dickinson JE, 'Induction of labor in nulliparous women with an unfavorable cervix: A randomized controlled trial comparing double and single balloon catheters and PGE2 gel', Obstetrical and Gynecological Survey, 65 78-80 (2010)
DOI 10.1097/01.ogx.0000368138.31846.fc
Citations Scopus - 1
2010 Elks CE, Perry JRB, Sulem P, Chasman DI, Franceschini N, He C, et al., 'Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies', Nature Genetics, 42 1077-1085 (2010)

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 wome... [more]

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 × 10 -60) and 9q31.2 (P = 2.2 × 10 -33), we identified 30 new menarche loci (all P < 5 × 10 -8) and found suggestive evidence for a further 10 loci (P < 1.9 × 10 -6). The new loci included four previously associated with body mass index (in or near FTO, SEC16B, TRA2B and TMEM18), three in or near other genes implicated in energy homeostasis (BSX, CRTC1 and MCHR2) and three in or near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and gene-set enrichment pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing. © 2010 Nature America, Inc. All rights reserved.

DOI 10.1038/ng.714
Citations Scopus - 313
2010 White CRH, Doherty DA, Henderson JJ, Kohan R, Newnham JP, Pennell CE, 'Benefits of introducing universal umbilical cord blood gas and lactate analysis into an obstetric unit', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 50 318-328 (2010)
DOI 10.1111/j.1479-828X.2010.01192.x
Citations Scopus - 24Web of Science - 15
2010 Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, et al., 'Low-Moderate Prenatal Alcohol Exposure and Risk to Child Behavioral Development: A Prospective Cohort Study EDITORIAL COMMENT', OBSTETRICAL & GYNECOLOGICAL SURVEY, 65 759-760 (2010)
DOI 10.1097/OGX.0b013e31821341bd
Citations Scopus - 2Web of Science - 2
2010 Whitehouse AJO, Robinson M, Zubrick SR, Ang QW, Stanley FJ, Pennell CE, 'Maternal life events during pregnancy and offspring language ability in middle childhood: The Western Australian Pregnancy Cohort Study', EARLY HUMAN DEVELOPMENT, 86 487-492 (2010)
DOI 10.1016/j.earlhumdev.2010.06.009
Citations Scopus - 19Web of Science - 16
2010 Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, et al., 'Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight', NATURE GENETICS, 42 430-U73 (2010)
DOI 10.1038/ng.567
Citations Scopus - 148Web of Science - 145
2010 Pennell CE, Henderson JJ, Dickinson JE, 'Induction of labour in nulliparous women with an unfavourable cervix Authors' Reply', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 117 892-893 (2010)
DOI 10.1111/j.1471-0528.2010.02557.x
Citations Scopus - 4
2010 Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, et al., 'Low-moderate prenatal alcohol exposure and risk to child behavioural development: a prospective cohort study', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 117 1139-1150 (2010)
DOI 10.1111/j.1471-0528.2010.02596.x
Citations Scopus - 89Web of Science - 93
2010 Robinson M, Oddy WH, McLean NJ, Jacoby P, Pennell CE, de Klerk NH, et al., 'Child behaviour following low to moderate maternal drinking in pregnancy Reply', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 117 1564-1565 (2010)
DOI 10.1111/j.1471-0528.2010.02718.x
Citations Scopus - 1
2010 Gracie SK, Lyon AW, Kehler HL, Pennell CE, Dolan SM, McNeil DA, et al., 'All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment', BMC PREGNANCY AND CHILDBIRTH, 10 (2010)
DOI 10.1186/1471-2393-10-87
Citations Scopus - 44Web of Science - 50
2009 Pennell CE, Henderson JJ, O'Neill MJ, McCleery S, Doherty DA, Dickinson JE, 'Induction of labour in nulliparous women with an unfavourable cervix: A randomised controlled trial comparing double and single balloon catheters and PGE

Objective To compare the efficacy and patient satisfaction of three methods of labour induction (double balloon catheters, single balloon catheters and prostaglandin gel) in term ... [more]

Objective To compare the efficacy and patient satisfaction of three methods of labour induction (double balloon catheters, single balloon catheters and prostaglandin gel) in term nulliparous women with unfavourable cervices. Design Randomised controlled trial. Population A total of 330 nulliparous women with unfavourable cervices induced at term. Methods Three cervical ripening study arms were used: double balloon catheter (107 women); 16F Foley catheter (110 women) and PGE2 gel (2 mg) (113 women). Main outcome measures Caesarean section, induction to delivery interval, adverse reactions and patient satisfaction. Results There was no difference in caesarean delivery rates between groups (double balloon 43%, single balloon 36%, PGE2 37%, P = 0.567). The induction to delivery interval was longer in the double balloon group (median 24.5; 95% CI 23.7, 30.6 hours) than the single balloon (23.2; 20.8, 25.8 hours) or PGE2 (23.8; 21.7, 26.8 hours) (P = 0.043). Uterine hyperstimulation occurred in 14% of the PGE2 group with none occurring with mechanical cervical ripening. Cord blood gases were worse in the PGE2 group: median arterial pH double balloon 7.26 (range 7.03-7.40); single balloon 7.26 (7.05-7.44); PGE2 7.25 (6.91-7.41) (P = 0.050). Cervical ripening with the single balloon catheter was associated with significantly less pain (pain score =4: double balloon 55%, single balloon 36%, PGE2 63%, P < 0.001). Conclusions Labour induction in nullipara with unfavourable cervices results in high caesarean delivery rates. Although all methods in this study had similar efficacy, the single balloon catheter offers the best combination of safety and patient comfort. © RCOG 2009 BJOG An International Journal of Obstetrics and Gynaecology.

DOI 10.1111/j.1471-0528.2009.02279.x
Citations Scopus - 112
2009 Newnham JP, Newnham IA, Ball CM, Wright M, Pennell CE, Swain J, Doherty DA, 'Treatment of Periodontal Disease During Pregnancy A Randomized Controlled Trial', OBSTETRICS AND GYNECOLOGY, 114 1239-1248 (2009)
DOI 10.1097/AOG.0b013e3181c15b40
Citations Scopus - 116Web of Science - 108
2009 Knight BS, Sunn N, Pennell CE, Adamson SL, Lye SJ, 'Developmental regulation of cardiovascular function is dependent on both genotype and environment', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 297 H2234-H2241 (2009)
DOI 10.1152/ajpheart.01338.2008
Citations Scopus - 8Web of Science - 10
2009 Newnham JP, Pennell CE, Lye SJ, Rampono J, Challis JRG, 'Early Life Origins of Obesity', OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA, 36 227-+ (2009)
DOI 10.1016/j.ogc.2009.03.004
Citations Scopus - 24Web of Science - 21
2008 Biggio J, Christiaens I, Katz M, Menon R, Merialdi M, Morken NH, et al., 'A call for an international consortium on the genetics of preterm birth', American Journal of Obstetrics and Gynecology, 199 95-97 (2008)
DOI 10.1016/j.ajog.2008.06.012
Citations Scopus - 13
2007 O'Leary CM, De Klerk N, Keogh J, Pennell C, De Groot J, York L, et al., 'Trends in mode of delivery during 1984-2003: Can they be explained by pregnancy and delivery complications?', BJOG: An International Journal of Obstetrics and Gynaecology, 114 855-864 (2007)

Objectives: To describe trends in mode of delivery, to identify significant factors which affected mode of delivery, and to describe how these factors and their impact have change... [more]

Objectives: To describe trends in mode of delivery, to identify significant factors which affected mode of delivery, and to describe how these factors and their impact have changed over time. Design: Total population birth cohort. Setting: Western Australia 1984-2003. Participants: The analysis was restricted to all singleton infants delivered at 37-42 weeks of gestation with a cephalic presentation (n = 432 327). Methods: Logistic regression analyses were undertaken to estimate significant independent risk factors separately for elective and emergency caesarean sections compared with vaginal delivery (spontaneous and instrumental), adjusting for potential confounding variables. Main outcome measures: Trends in mode of delivery, demographic factors, and pregnancy and delivery complications. Estimated likelihood of elective caesarean section compared with vaginal delivery and emergency caesarean section compared with vaginal delivery. Results: Between 1984-88 and 1999-2003, the likelihood of women having an elective caesarean section increased by a factor of 2.35 times (95% CI 2.28-2.42) and the likelihood of an emergency caesarean section increased 1.89 times (95% CI 1.83-1.96). These caesarean section rate increases remained even after adjustment for their strong associations with many sociodemographic factors, obstetric risk factors, and obstetric complications. Rates of caesarean section were higher in older mothers, especially those older than 40 years of age (elective caesarean section, OR 5.42 [95% CI 4.88-6.01]; emergency caesarean section, OR 2.67 [95% CI 2.39-2.97]), and in nulliparous women (elective caesarean section, OR 1.54 [95% CI 1.47-1.61]; emergency caesarean section, OR 3.61 [95% CI 3.47-3.76]). Conclusions: Our data show significant changes in mode of delivery in Western Australia from 1984-2003, with an increasing trend in both elective and emergency caesarean section rates that do not appear to be explained by increased risk or indication. © RCOG 2007 BJOG An International Journal of Obstetrics and Gynaecology.

DOI 10.1111/j.1471-0528.2007.01307.x
Citations Scopus - 85
2007 Pennell CE, Jacobsson B, Williams SM, Buns RM, Muglia LJ, Dolan SM, et al., 'Genetic epidemiologic studies of preterm birth: guidelines for research', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 196 107-118 (2007)
DOI 10.1016/j.ajog.2006.03.109
Citations Scopus - 105Web of Science - 100
2007 Pennell CE, Muglia LJ, Relton C, 'Genetic epidemiologic studies of preterm birth: studies of disease or of "rescue by birth"?', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 197 439-439 (2007)
DOI 10.1016/j.ajog.2007.06.082
2007 Sloboda DM, Hart R, Doherty DA, Pennell CE, Hickey M, 'Rapid communication - Age at menarche: Influences of prenatal and postnatal growth', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 92 46-50 (2007)
DOI 10.1210/jc.2006-1378
Citations Scopus - 181Web of Science - 164
2007 Knight BS, Pennell CE, Adamson SL, Lye SJ, 'The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy', JOURNAL OF PHYSIOLOGY-LONDON, 581 873-881 (2007)
DOI 10.1113/jphysiol.2006.126573
Citations Scopus - 15Web of Science - 16
2007 Knight BS, Pennell CE, Shah R, Lye SJ, 'Strain differences in the impact of dietary restriction on fetal growth and pregnancy in mice', REPRODUCTIVE SCIENCES, 14 81-90 (2007)
DOI 10.1177/1933719106298217
Citations Scopus - 12Web of Science - 12
2001 Rogers MS, Murray HG, Wang CC, Pennell CE, Turner A, Yan P, et al., 'Oxidative stress in the fetal lamb brain following intermittent umbilical cord occlusion: A path analysis', British Journal of Obstetrics and Gynaecology, 108 1283-1290 (2001)

Objective To evaluate the relative contribution of cord occlusion length intervals between occlusions and experimental duration on oxidative stress in the fetal lamb brain. Design... [more]

Objective To evaluate the relative contribution of cord occlusion length intervals between occlusions and experimental duration on oxidative stress in the fetal lamb brain. Design Acute, partially exteriorised fetal lambs with intermittent total cord occlusion. Setting The Vivarium of Westmead Hospital, University of Sydney, Australia and The Chinese University of Hong Kong. Main outcome measures Arterio-venous differences in the concentration of organic hydroperoxides, measured in paired samples of carotid arterial and jugular venous blood, as an index of oxidative stress in the brain. Methods Thirty-two fetal lambs were exposed to graded hypoxia, induced by intermittent total umbilical cord compression of 30 seconds, 60 seconds and 90 seconds duration, occurring every minute for a total of 27 occlusions over 81 minutes. Three sham experiments were also performed. In addition to organic hydroperoxides, carotid arterial blood samples were also assayed in 15 animals (two sham) for oxygen saturation, pH, hypoxanthine, xanthine and urate concentrations. A causal model for oxidative stress was defined: occlusions leading to hypoxia with a rise in hypoxanthine; reperfusion during intervals between occlusions leading to the accelerated production of xanthine and uric acid and the generation of oxygen free radicals, which in turn, are responsible for the rise in lipid peroxidation. Path analysis was performed to assess the strength of the relationships between these variables and the cord occlusion length, the interval between occlusions and the duration of the experiment. Results Sham experiments showed no change in organic hydroperoxide production. Following 30-second umbilical cord occlusions a sixfold drop in mean organic hydroperoxides was observed between carotid arterial and jugular venous levels. In contrast, following occlusions of 60 seconds duration (or longer) a median 20-fold increase in organic hydroperoxide production was observed. Path analysis revealed a strong indirect pathway from occlusion length ¿ hypoxanthine ¿ urate and weak positive pathways from oxygen saturation¿ urate and from interval between occlusions ¿ urate. After accounting for these pathways reflecting oxidative stress, a strong direct path remained from time from first occlusion ¿ organic hydroperoxide production. Conclusions Peroxidation of lipids in the brain occurs under conditions of severe hypoxia and reperfusion associated with intermittent umbilical cord occlusions of 60 seconds or longer. The path analysis supported the causal model as originally defined, with the exception that the indirect pathway via pH was found to be trivial.

DOI 10.1016/S0306-5456(01)00297-2
Citations Scopus - 11
1999 Pennell CE, Tracy MB, 'A new method for rapid measurement of lactate in fetal and neonatal blood', Australian and New Zealand Journal of Obstetrics and Gynaecology, 39 227-233 (1999)

A prospective trial to determine the accuracy and precision of the Boehringer Mannheim Accusport® handheld lactate meter in measuring plasma lactate levels in umbilical cord blood... [more]

A prospective trial to determine the accuracy and precision of the Boehringer Mannheim Accusport® handheld lactate meter in measuring plasma lactate levels in umbilical cord blood and neonatal blood microsamples was performed in the labour ward and the neonatal intensive care unit of the Nepean Hospital. Specimens were collected from the umbilical arrery of 160 consecutive deliveries covering gestations from 26 to 42 weeks, and from 110 umbilical artery catheters covering a range of gestations from 26 to 41 weeks. Serum was also obtained from an exchange transfusion for coefficient of variation analysis. Blood was simultaneously tested for lactic acid concentration on the Boehringer Mannheim (BM) Accusport® held lactate meter acid the Radiometer ABL 625® blood-gas machine. Clinical data from the mother and baby were recorded together with the full blood-gas analysis for comparison with the lactate measures. Coefficients of variation for the BM Accusport® lactate meter were established by a further 120 samples of plasma lactate at 6 concentrations from 1 to 20 mmol/L. The stability of measurements with the BM lactate meter over a wide range of temperatures was ascertained by repeated sampling of known concentrations of plasma lactate from 0.5°C to 37°C. The BM Accusport® lactate meter was found to be accurate from 1 mmol/L to 20 mmol/L with a Passing Bablok regression line y = 0.004 + 0.915 x (95% CI of slope of 0.889 to 0.946 acid intercept -0.138 to 0.094) for whole blood, and y = 0.200 + 1.000 x (95% CI of slope 0.989 to 1.018 and intercept 0.080 to 0.222) for plasma. Between run coefficient of variation (CV) was calculated to be 1.23% to 5.53% over the clinically significant range (2.2-19.3 mmol/L). The BM lactate meter was accurate from 5 to 37°C. At 0.5°C the BM lactate meter significantly underestimated the plasma lactate concentration. There was no significant effect of haematocrit (41.5 to 62%), gestation, or operator on the accuracy of the BM lactate meter. The Accusport® handheld lactate meter is an accurate, commerciailv available, method of measuring plasma lactate levels in only 60 seconds at the point-of-care. It requires only 15µL of blood and is significantly cheaper than other assay methods. The BM lactate meter is well suited to assess lactic acidaemia of fetal scalp and neonatal blood samples to help quantify hypoxic stress in the perinatal period.

DOI 10.1111/j.1479-828X.1999.tb03379.x
Citations Scopus - 27
Show 213 more journal articles

Conference (87 outputs)

Year Citation Altmetrics Link
2019 Henriksen L, Mathiesen B, Assens M, Krause M, Skakkebaek NE, Juul A, et al., 'Use of stored serum in the study of time trends and geographical differences in exposure of pregnant women to phthalates', HORMONE RESEARCH IN PAEDIATRICS (2019)
2019 Wang CA, Penova-Veselinovic B, White MK, Ang QW, Williams S, Pennell CE, 'Preterm Birth Genome Project (PGP) Phase III: Development of a Bespoke PTB Array, globePTB.', REPRODUCTIVE SCIENCES, Paris, FRANCE (2019)
2019 Pennell CE, Wang CA, Lye SJ, Oddy W, Mori T, Meyerkort C, Beilin L, 'Precision Medicine in the First 1000 Days: Trajectories to a Healthy Future.', REPRODUCTIVE SCIENCES, Paris, FRANCE (2019)
2018 St Pourcain B, Vitart V, Zeggini E, Dedoussis G, Jaddoe V, Pennell CE, et al., 'Low frequency genetic variation in the TP53 locus has large effects on head circumference and intracranial volume', BEHAVIOR GENETICS, Boston, MA (2018)
2018 Wang CA, White MK, Penova-Veselinovic B, Ang WQ, Williams S, Pennell CE, 'Preterm Birth Genome Project (PGP) Phase III Development of a Bespoke PTB Array', REPRODUCTIVE SCIENCES, San Diego, CA (2018)
2018 White MK, Pennell CE, Wang CA, Straker L, Eastwood P, 'Failing to Plan is Planning to Fail: Research Management in a Successful, Longitudinal Pregnancy Cohort.', REPRODUCTIVE SCIENCES, San Diego, CA (2018)
2017 Pennell CE, Cheng JC, Penova-Veselinovic B, Wang CA, Ingleby B, Arnold CC, et al., 'Single Dose Anti-D Prophylaxis in Pregnancy: Is It Time to Change?', REPRODUCTIVE SCIENCES, Orlando, FL (2017)
2017 Wang CA, Ang W, White S, White MK, Mackey D, Lye SJ, Pennell CE, 'Targeting Interventions to Prevent Adult Consequences of Impaired Fetal Growth.', REPRODUCTIVE SCIENCES, Orlando, FL (2017)
2016 White CRH, Tuson M, Wang C, Kohan R, Newnham JP, Pennell CE, 'Cord Blood Gas and Lactate Analysis: What Happens When They Disagree?', REPRODUCTIVE SCIENCES, Montreal, CANADA (2016)
2016 White SW, Bakalis S, Peebles DM, Pennell CE, 'Maternal Characteristics Influence Gestation Length and Perinatal Morbidity and Mortality', REPRODUCTIVE SCIENCES, Montreal, CANADA (2016)
2016 Pennell CE, Wang C, Ang W, White M, White SW, Mackey D, Lye SJ, 'Novel Common Genomic Variants Influence Fetal Growth and Adult Metabolic Phenotypes.', REPRODUCTIVE SCIENCES, Montreal, CANADA (2016)
2015 Adams LA, Wree A, Melton P, Jeffrey GP, Ching H, de Boer B, et al., 'Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphisms', HEPATOLOGY, San Francisco, CA (2015)
Citations Web of Science - 1
2015 Heng YJ, Pennell CE, McDonald SW, Vinturache AE, Xu J, Lee MWF, et al., 'Maternal Whole Blood Gene Expression Predicts Spontaneous Preterm Birth in Asymptomatic Women as Early as 18 Weeks Gestation', REPRODUCTIVE SCIENCES (2015)
2015 White CRH, Doherty DA, Cannon J, Kohan R, Newnham JP, Pennell CE, 'Universal Umbilical Blood Gas Analysis: A Cost-Effective Way To Decrease SCN Admissions', REPRODUCTIVE SCIENCES (2015)
2015 Herbison C, Allen K, Robinson M, Pennell C, 'Trajectories of stress events from early life to adolescence predict depression, anxiety and stress in young adults', PSYCHONEUROENDOCRINOLOGY, Edinburgh, SCOTLAND (2015)
DOI 10.1016/j.psyneuen.2015.07.432
Citations Web of Science - 1
2014 McCarthy N, Cunnenn RJ, Ang WQ, White MK, Merialdi M, Williams S, et al., 'Meta-Analysis of SNPs from Caucasian, Maternal Candidate Gene Association Studies for Spontaneous PTB with the Results of the PGP Consortium GWAS.', REPRODUCTIVE SCIENCES, Florence, ITALY (2014)
2014 McCarthy N, Cunneen RJ, Ang W, White MK, Merialdi M, Katz M, et al., 'Further Evidence for the Involvement of Two Functional Polymorphisms in Folate Metabolising Genes, SHMT1(1420)T and MTRR(66)A, with an Increased Risk of Early Spontaneous Preterm Birth from the PGP Consortium GWAS.', REPRODUCTIVE SCIENCES, Florence, ITALY (2014)
2014 Pennell CE, Warrington NM, Herbison C, Henley D, Newnham JP, Matthews S, Lye SJ, 'HPA Axis Responsiveness at 18 Years Mediates the "U Shaped Curve" Relationship between Birthweight and Adult Obesity.', REPRODUCTIVE SCIENCES, Florence, ITALY (2014)
2013 Christiaens I, Pennell CE, Fang X, Ang QW, Olson DM, 'Two Novel Genetic Variants in the Mineralocorticoid Receptor Gene Associate with Spontaneous Preterm Birth', REPRODUCTIVE SCIENCES, Orlando, FL (2013)
2013 Shynlova O, Srikhajon K, Warrington N, Pennell C, Lye S, 'Myomesin2 Gene and Protein Expression in Human and Mouse Myometrium Is Associated with Labour Onset', REPRODUCTIVE SCIENCES, Orlando, FL (2013)
2013 Heng YJ, Lee MWF, Larsen BG, Taylor L, Tucholska M, Pennell CE, et al., 'Differential Expression of Leukocyte Lysate Proteins in Threatened Preterm Labour Using iTRAQ', REPRODUCTIVE SCIENCES, Orlando, FL (2013)
2013 Pennell CE, Ang QW, Marsh JA, White SW, Briolais L, White MK, et al., 'Genetic Influences on Fetal Growth Are Specific to Head Circumference, Abdominal Circumference and Femur Length', REPRODUCTIVE SCIENCES, Orlando, FL (2013)
2012 White SW, Marsh JA, Ang W, Warrington NM, Newnham JP, Lye SJ, Pennell CE, 'Maternal-Fetal Genetic Influences of Fetal Growth.', REPRODUCTIVE SCIENCES (2012)
2012 Louise S, Briollais L, Mori TA, Mattes E, McCaskie PA, Pennell CE, et al., 'THE PLEIOTROPHIC EFFECT OF LEPTIN AND LEPTIN RECEPTOR GENES ON BMI AND AGGRESSION SCORES IN ADOLESCENTS', HYPERTENSION, Perth, AUSTRALIA (2012)
2012 Tan A, Forward H, McKnight C, Yazar S, Pennell C, Young T, et al., 'CHOROIDAL THICKNESS ASSOCIATED WITH SPHERICAL EQUIVALENT IN HEALTHY YOUNG ADULTS: THE RAINE EYE HEALTH STUDY', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2012)
2012 Heng YJ, Taylor L, Kupchak P, Dharsee M, Tate SA, Pawson T, et al., 'Identification of Informative Biomarkers for Threatened Preterm Labour Using Novel Mass Spectrometry Methodologies.', REPRODUCTIVE SCIENCES (2012)
2012 Sabra S, Shynlova O, Pennell C, Lye S, 'Activation Status of Maternal Leukocytes and Cytokine Profile Predicts Imminent Preterm Delivery', REPRODUCTIVE SCIENCES (2012)
Citations Web of Science - 1
2012 Connor KL, Matysiak E, Chun L, Knight B, Pennell CE, Lye SJ, 'Novel Genetic Associations with Compromised Metabolic Phenotypes in a Mouse Model of Maternal Undernutrition', REPRODUCTIVE SCIENCES (2012)
2012 Ang QW, Slater MK, Menon R, Lye SJ, Merialdi M, Pennell CE, 'Novel Insights into the Genetics of Early Spontaneous Preterm Birth Using Multigenic Modelling', REPRODUCTIVE SCIENCES (2012)
2012 Pennell CE, Marsh JA, Ang QW, Taal HR, Palmer LJ, Lye SJ, et al., 'Maternal and Fetal Genotype Is Required To Understand the Full Impact of Genetics on Fetal Growth.', REPRODUCTIVE SCIENCES (2012)
2012 Maganga R, Marsh JA, Lye SJ, Pennell CE, 'Telomere Length in an Adolescent Population: Association with the Duration of Breast-Feeding.', REPRODUCTIVE SCIENCES (2012)
2011 McKnight C, Sherwin J, Yazar S, Pennell C, Mountain J, Coroneo M, Mackey D, 'PREVALENCE AND AUTOFLUORESCENCE CHARACTERISTICS OF PTERYGIUM IN YOUNG AUSTRALIAN ADULTS', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2011 Forward H, Khan J, Tan A, Newnham J, Pennell C, Mountain J, et al., 'OCULAR AXIAL LENGTH AND ITS ASSOCIATIONS IN YOUNG ADULTS', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2011 Atkinson HC, Penova-Veselinovic B, Ang QW, van Eekelen JAM, Lye SJ, Matthews SG, et al., 'Early Life Programming of the HPA Axis: Effects of Maternal Stress', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Chun LA, Knight BS, Pennell CE, Lye SJ, 'Evidence of Hepatic Insulin Resistance in Fetal C57BL/6J Mice Subjected to Maternal Dietary Restriction', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Atkinson HC, Penova-Veselinovic B, Ang QW, van Eekelen JAM, Lye SJ, Matthews SG, et al., 'Fetal Programming of the HPA Axis: Effects of Birth Weight and Sex in an Adolescent Population', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Marsh JA, White SW, Warrington NM, Lye SJ, Smith GD, Newnham JP, et al., 'Feeding the Epidemic of Childhood Obesity', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Meyerkort CE, Oddy WH, O'Sullivan TA, Henderson J, Pennell CE, 'Early Diet Quality in a Longitudinal Study of Australian Children: Associations with Nutrition and Body Mass Index Later in Childhood and Adolescence', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Louise S, Briollais L, Mattes E, McCaskie P, Oddy WH, Mori T, et al., 'MONOAMINE OXIDASE A (MAOA) IS ASSOCIATED WITH DEPRESSIVE SYMPTOM SCORES AND BLOOD PRESSURE IN ADOLESCENT BOYS BUT NOT GIRLS', HYPERTENSION, Melbourne, AUSTRALIA (2011)
2011 Hart R, Doherty DA, Newnham IA, Pennell CE, Newnham JP, 'Periodontal disease a further potentially modifiable risk factor limiting conception a case for a pre-pregnancy dental check-up?', HUMAN REPRODUCTION, Stockholm, SWEDEN (2011)
2011 Forward H, Newnham J, Khan J, Pennell C, Mountain J, Mackey D, 'INTENSIVE PRENATAL ULTRASOUND DOES NOT IMPAIR EYE DEVELOPMENT-20 YEAR OCULAR FOLLOW UP OF A RCT', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2011 McKnight C, Sherwin J, Yazar S, Pennell C, Mountain J, Coroneo M, Mackey D, 'CONJUNCTIVAL ULTRAVIOLET AUTOFLUORESCENCE IN YOUNG ADULTS', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2011 Tan A, Chen F, Forward H, Mountain J, Newnham J, Pennell C, Mackey D, 'CENTRAL MACULAR THICKNESS MEASUREMENTS IN YOUNG ADULTS MEASURED BY SPECTRALIS OPTICAL COHERENCE TOMOGRAPHY', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2011 Tan A, Mackey D, Forward H, Mountain J, Newnham J, Pennell C, Chen F, 'INCREASED SPHERICAL EQUIVALENT ASSOCIATED WITH GREATER SUBFOVEAL CHOROIDAL THICKNESS IN YOUNG ADULTS MEASURED USING OPTICAL COHERENCE TOMOGRAPHY', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2011 Tan A, Chen F, Mountain J, Newnham J, Pennell C, Mackey D, 'INTEROCULAR SYMMETRY IN MACULAR AND SUBFOVEAL CHOROIDAL THICKNESS WITH THE SPECTRALIS OPTICAL COHERENCE TOMOGRAPHY IN HEALTHY YOUNG ADULTS', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2011 White SW, Wa NM, Marsh JA, Beilin LJ, Newnham JP, Palmer LJ, et al., 'Genetic Variants Associated with Adult Glucose Homeostasis Are Associated with Fetal Growth Trajectories and Adolescent Insulin Resistance', REPRODUCTIVE SCIENCES (2011)
2011 Pennell CE, Vidillo-Ortega F, Ha E-H, Olson D, Thorsen P, Merialdi M, et al., 'PGP Consortium - Optimal Sample Handling for GWAS', REPRODUCTIVE SCIENCES (2011)
2011 Ang QW, Huang R-C, Pennell CE, Warrington NM, Lye SJ, Briollais L, et al., 'HPA Related Genes Are Associated with Antenatal Growth and Childhood Blood Pressure Trajectories', REPRODUCTIVE SCIENCES (2011)
2011 Penova-Veselinovic B, Atkinson HC, Ang QW, van Eekelen JAM, Lye SJ, Matthews SG, et al., 'Fetal Programming of the HPA Axis: Effects of Birth Weight and Sex in an Adolescent Population', REPRODUCTIVE SCIENCES (2011)
2011 Warrington NM, Mook-Kanamori DO, Marsh JA, Taal HR, Newnham JP, Beilin LJ, et al., 'Variants near CCNL1/LEKR1 and in ADCY5 and Fetal Growth Characteristics in Different Trimesters', REPRODUCTIVE SCIENCES (2011)
2011 Keelan JA, Colvin R, Mas E, Pennell CE, Waddell BJ, Mark PJ, et al., 'A Fish-Enriched Diet in Pregnancy Is Associated with Enhanced Levels of Resolvin and Protectin Precursors in the Human Placenta at Term', REPRODUCTIVE SCIENCES (2011)
2011 Pennell CE, Ang QW, Merialdi M, Williams S, Thorsen P, Katz M, et al., 'Preterm Birth Genome Project - Identification of Genetic Variants Associated with Spontaneous Preterm Birth', REPRODUCTIVE SCIENCES (2011)
2011 Pennell CE, Warrington NM, Mook-Kanamori D, Lye SJ, Newnham JP, Palmer LJ, et al., 'Genetic Basis for Gestation Length', REPRODUCTIVE SCIENCES (2011)
2011 Brion M-JA, Robinson M, Matijasevich A, Steer C, Anselimi L, Menezes AMB, et al., 'Maternal Prenatal Smoking and Child Aggression: Exploring Intrauterine Effects in UK, Australian and Brazilian Cohorts', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Maganga R, Chun L, Pennell CE, Lye SJ, 'Telomere Shortening Correlates with Programming of the Metabolic Syndrome Phenotype', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Pennell CE, Marsh JA, Ang QW, Taal HR, Palmer LJ, Lye SJ, et al., 'Maternal and Fetal Genotype Is Required to Understand the Full Impact of Genetics on Fetal Growth', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Parmar PG, Marsh JA, Taal RH, Newnham JP, Uitterlinden AG, Briollais L, et al., 'Polymorphisms in Genes within the IGF-Axis Influence Antenatal and Postnatal Growth', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Warrington NM, Marsh JA, Newnham JP, Beilin LJ, Lye SJ, Briollais L, Pennell CE, 'Genetic Variants in Adult Obesity Genes Are Associated with Childhood Growth', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011)
2011 Forward H, Khan J, Tan A, Newnham J, Bulsara M, Pennell C, et al., 'OCULAR AXIAL LENGTH AND ITS ASSOCIATIONS IN YOUNG ADULTS', CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2011)
2010 Pennell CE, Ang QW, van Eekelen JAM, Marsh JA, Briollais L, Newhnam JP, et al., 'Polymorphisms in Genes That Regulate HPAAxis Function Are Associated with Antenatal Fetal Growth Trajectories and Postnatal HPA Axis', REPRODUCTIVE SCIENCES, Orlando, FL (2010)
2010 Ang QW, Pennell CE, Ayonrinde OT, Olynyk JK, Warrington NM, Palmer LJ, et al., 'Gene-Environment Interactions Underlying the Development of Non-Alcoholic Fatty Liver Disease (NAFLD) in Adolescence', REPRODUCTIVE SCIENCES, Orlando, FL (2010)
2009 Pennell CE, Marsh JA, Warrington NM, Beilin LJ, Newnham JP, Lye SJ, Palmer LJ, 'Polymorphism in FTO Links Fetal Growth Trajectories to Childhood BMI', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009)
2009 Henderson JJ, Doherty DA, Dickinson JE, Pennell CE, 'Failed Induction in the Nulliparous Woman with Unfavorable Cervix: Predictive Factors', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009)
2009 Shynlova O, Pennell C, Whittle W, Lye S, 'Increased Maternal Peripheral White Blood Cell Count Is a Marker of Active Human Labor', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009)
Citations Web of Science - 2
2009 Pennell CE, Knight BS, Chun L, Warrington NM, Beilin LJ, Mori TA, et al., 'Integrated Approaches To Investigate the Influence of Omega-3 Fatty Acids on Obesity and Glucose Tollerance', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009)
2009 Hunter TJ, Bymes MJ, Gill A, Nathan E, Pennell CE, 'Prediction of Survival in Extreme Preterm Premature Rupture of Membranes (PPROM', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009)
2009 Kamara M, Dickinson JE, Pennell CE, 'Preventing Placenta Accreta - The First Cut Should Not Be the Deepest', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009)
2009 Petersen S, Lewi P, Diemert A, Lewi L, Dickinson J, Pennell C, et al., 'Fetoscopic entry technique affects the rate of preterm membrane rupture and preterm birth before 32 weeks', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, Chicago, IL (2009)
DOI 10.1016/j.ajog.2009.10.583
2009 Ayonrinde OT, Olynyk JK, Pennell CE, Beilin LJ, Mori TA, Oddy WH, et al., 'GENE-ENVIRONMENT INTERACTIONS UNDERLYING THE DEVELOPMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE IN ADOLESCENCE ARE INFLUENCED BY GENDER', HEPATOLOGY, Boston, MA (2009)
2009 Warrington NM, Briollais L, Marsh JA, Pennell CE, Lye SJ, Palmer LJ, 'Modelling Complex Longitudinal Data in Genetic Association analyses', GENETIC EPIDEMIOLOGY, Honolulu, HI (2009)
2009 Ayonrinde OT, Olynyk JK, Pennell CE, Warrington NM, Palmer LJ, Beilin LJ, et al., 'Polymorphisms in adiponectin gene are associated with non-alcoholic fatty liver disease (NAFLD) in Western Australian adolescents', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)
2009 Ayonrinde OT, Olynyk JK, Pennell CE, Ang W, Warrington NM, Palmer LJ, et al., 'Polymorphisms in the C-reactive protein (CRP) gene are associated with non-alcoholic fatty liver disease (NAFLD) in Western Australian adolescents independent of insulin resistance', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2009)
2009 Newnham JP, Newnham IA, Ball CM, Wright M, Swain J, Pennell CE, Doherty DA, 'Treatment of Periodontal Disease during Pregnancy May Prevent Stillbirth but Does Not Prevent Preterm Birth.', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009)
2008 Nijs S, De Buck F, Pennell C, Porter J, Vandevelde M, Van Schoubroeck D, et al., 'OUTCOMES OF DIFFERENT ANESTHETIC TECHNIQUES IN FETOSCOPIC LASER TREATMENT FOR TTTS', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, San Diego, CA (2008)
DOI 10.1016/j.ajog.2008.09.619
2008 White CRH, Doherty DA, Kohan R, Pennell CE, 'Universal umbilical cord sampling is associated with improved perinatal outcome', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY (2008)
2008 Pennell CE, Bosel KJ, Perkins JE, Bocking AD, Lye SJ, 'Gene expression signature in leukocytes accurately predicts preterm delivery in women with threatened preterm labour', REPRODUCTIVE SCIENCES, San Diego, CA (2008)
2008 Mulroy SM, Dudman E, Dickinson JE, Newnham JP, Pennell CE, 'Hydrops fetalis: Etiology and outcome 1995-2005', REPRODUCTIVE SCIENCES, San Diego, CA (2008)
2008 Drewlo S, Baczyk D, Pennell C, Dunk C, Caniggia I, Kingdom J, 'GCM1 mediates TIMP4 expression in BeWO and first trimester trophoblast explants.', REPRODUCTIVE SCIENCES, San Diego, CA (2008)
2008 White CR, Doherty DA, Kohan R, Newnham JP, Pennell CE, 'Prediction of neonatal hypoxic ischaemic encephalopathy from umbilical artery blood gas analysis at delivery.', REPRODUCTIVE SCIENCES, San Diego, CA (2008)
2008 White CR, Doherty DA, Kohan R, Newnham JP, Pennell CE, 'Universal umbilical cord sampling is associated with improved perinatal outcome.', REPRODUCTIVE SCIENCES, San Diego, CA (2008)
2007 Knight BS, Pennell CE, Lye SJ, 'Fetal HPA activation controls glucose regulation in a strain dependent manor in mice subjected to an adverse intrauterine environment', EARLY HUMAN DEVELOPMENT (2007)
DOI 10.1016/S0378-3782(07)70110-X
2007 Knight BS, Pennell CE, Lye SJ, 'Programming of type II diabetes and adult liver dysfunction is dependent on genetic background in mice', EARLY HUMAN DEVELOPMENT (2007)
DOI 10.1016/S0378-3782(07)70084-1
2006 Pennell CE, Oldenhof AD, Perkins JE, Dunk CE, Keunen J, Tan PL, et al., 'Identification of a gene expression signature in leukocytes that predicts preterm delivery in women with threatened preterm labour.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Toronto, CANADA (2006)
Citations Web of Science - 3
2005 Keunen J, Pennell CE, Claudio JO, Bocking AD, Lye SJ, 'A proteomic approach to distinguish true from false pre-term labour.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
2005 Pennell CE, Dunk CE, Perkins JE, Keunen J, Bocking AD, Lye SJ, 'Identification of a gene expression signature in leukocytes that predicts pre-term delivery in women in threatened pre-term labour.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
2004 Pennell CE, Moss TJM, Turner AJ, Murray HG, Newnham JP, 'Fetal lactate levels predict fetal blood pressure responses during umbilical cord occlusion.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
2003 Pennell CE, Jewell M, Doherty DA, Dickinson JE, 'Induction of labor with an unfavorable cervix', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, NEW ORLEANS, LOUISIANA (2003)
DOI 10.1016/j.ajog.2003.10.550
Citations Web of Science - 2
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Grants and Funding

Summary

Number of grants 39
Total funding $27,099,510

Click on a grant title below to expand the full details for that specific grant.


20201 grants / $425,758

MRSP 2020 Pregnancy and Reproduction Program$425,758

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Roger Smith, Laureate Professor John Aitken, Professor Craig Pennell, Professor Lee Smith, Professor Jon Hirst, Professor Brett Nixon, Associate Professor Kirsty Pringle, Doctor Jonathan Paul, Doctor Jessie Sutherland
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2020
Funding Finish 2020
GNo G1901541
Type Of Funding C2220 - Aust StateTerritoryLocal - Other
Category 2220
UON Y

20193 grants / $972,266

New1000 - Optimising health in children for a healthy life$957,266

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Craig Pennell
Scheme Research Grant
Role Lead
Funding Start 2019
Funding Finish 2024
GNo G1901284
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

Precision medicine for trajectories to health rather than disease$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Craig Pennell
Scheme Research Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo G1901340
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

Newcastle 1000 Prospectus Development$5,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Craig Pennell
Scheme Project Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo G1900904
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

20182 grants / $110,087

Targeting Treatment Success to Prevent Preterm Birth$86,337

Funding body: Western Australia Department of Health

Funding body Western Australia Department of Health
Project Team Professor Craig Pennell, Professor Jeff keelan, Professor Richard Allcock
Scheme Telethon - Perth Children's Hospital Research Fund 2015
Role Lead
Funding Start 2018
Funding Finish 2018
GNo G1801076
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Neurosteroid therapy to prevent long-term behavioural deficits following prenatal stress exposure$23,750

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Hannah Palliser, Doctor Julia Shaw, Professor Jon Hirst, Professor Craig Pennell
Scheme Project Grant
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo G1801352
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

20172 grants / $4,956,278

Leveraging Leukocytes as Endogenous Biosensors to Create Novel Diagnostics for Preterm Birth$4,857,023

Funding body: Genome Canada

Funding body Genome Canada
Scheme Partnership Grant
Role Investigator
Funding Start 2017
Funding Finish 2021
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

The effect of migration and acculturation on risk of stillbirth in Western Australia$99,255

Funding body: Red Nose Trans - Tasman Research Funding

Funding body Red Nose Trans - Tasman Research Funding
Scheme Project Grant
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20161 grants / $94,570

A novel transcriptomic signature to predict spontaneous preterm birth$94,570

Funding body: Channel Seven Telethon Trust

Funding body Channel Seven Telethon Trust
Scheme Project Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding C3111 - Aust For profit
Category 3111
UON N

20151 grants / $300,000

Western Australian Preterm Birth Family Genetic Study - Utilising Next Generation Sequencing$300,000

Funding body: Channel Seven Telethon Trust

Funding body Channel Seven Telethon Trust
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON N

20141 grants / $50,000

Western Australian Preterm Birth Family Genetic Study $50,000

Funding body: Channel Seven Telethon Trust

Funding body Channel Seven Telethon Trust
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo
Type Of Funding C1700 - Aust Competitive - Other
Category 1700
UON N

20134 grants / $3,371,448

The Long Term Consequences of Assisted Reproduction on Development of the Offspring: A Prospective Cohort Study$1,552,096

Funding body: National Health & Medical Research Council

Funding body National Health & Medical Research Council
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2015
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

The International Preterm Birth Genome Project (PGP): utilising Australian samples in a global project to identify genetics variants associated with early preterm birth$1,238,161

Funding body: National Health & Medical Research Council

Funding body National Health & Medical Research Council
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2016
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

Exploring Gene Expression in White Blood cell subsets as predictors of preterm birth$541,240

Funding body: Global Alliance to Prevent Prematurity and Stillbirth (GAPPS)

Funding body Global Alliance to Prevent Prematurity and Stillbirth (GAPPS)
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2014
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Agilent 2200 Tape Station System$39,951

Funding body: National Health & Medical Research Council

Funding body National Health & Medical Research Council
Scheme Equipment Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

20122 grants / $642,445

GWAS to prevent Myopia$482,445

Funding body: National Health & Medical Research Council

Funding body National Health & Medical Research Council
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2015
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

Global Preterm Birth Genome Project (non-Caucasian sample collection)$160,000

Funding body: Channel Seven Telethon Trust

Funding body Channel Seven Telethon Trust
Scheme Channel Seven Telethon Trust
Role Lead
Funding Start 2012
Funding Finish 2012
GNo
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON N

20112 grants / $735,238

Early Risk Factors for Autism$671,928

Funding body: National Health & Medical Research Council

Funding body National Health & Medical Research Council
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2016
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

Rotorgene Q HRM Priority qPCR system$63,310

Funding body: National Health & Medical Research Council

Funding body National Health & Medical Research Council
Scheme Equipment Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

20103 grants / $2,568,331

A Murine Model to Investigate the Mechanisms Underlying DOHaD$970,591

Funding body: Canadian Institute of Health Research

Funding body Canadian Institute of Health Research
Scheme Project Grant (MOP 81238)
Role Investigator
Funding Start 2010
Funding Finish 2015
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Gene Environment Interactions Underlying DOHaD$944,434

Funding body: Canadian Institutes of Health Research

Funding body Canadian Institutes of Health Research
Scheme Project Grant (MOP-82893)
Role Investigator
Funding Start 2010
Funding Finish 2015
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Risk Factors for NAFLD: genes, early development and environment$653,306

Funding body: Australian National Health and Medical Research Council

Funding body Australian National Health and Medical Research Council
Scheme Project grant
Role Lead
Funding Start 2010
Funding Finish 2013
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

20093 grants / $1,914,500

Understanding Genetic and Environmental causes of Chronic Adult Disease in Early Life$989,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Scheme Project Grant
Role Lead
Funding Start 2009
Funding Finish 2012
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

Telethon Western Australian Preterm Birth Genome Project$700,000

Funding body: Channel Seven Telethon Trust

Funding body Channel Seven Telethon Trust
Scheme Equipment Grant
Role Lead
Funding Start 2009
Funding Finish 2011
GNo
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON N

An Investigation of Common Genes Influencing Cardiovascular Disease and Depression in Early Life$225,000

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Scheme Grant in Aid
Role Lead
Funding Start 2009
Funding Finish 2011
GNo
Type Of Funding C1700 - Aust Competitive - Other
Category 1700
UON N

20085 grants / $9,296,524

Preterm BIrth and Healthy Outcomes$5,000,000

Funding body: Alberta Heritage Foundation for Medical Research

Funding body Alberta Heritage Foundation for Medical Research
Scheme Alberta Heritage Foundation for Medical Research Interdisciplinary Team Grant
Role Investigator
Funding Start 2008
Funding Finish 2012
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Phenotypic effects from birth to adolescence of putative causal genetic variants$3,517,854

Funding body: National Institute for Health Research

Funding body National Institute for Health Research
Scheme Research Grant
Role Investigator
Funding Start 2008
Funding Finish 2012
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

Preterm Birth Genome Project$673,670

Funding body: World Health Organisation and March of Dimes Birth Defects Foundation Partnership

Funding body World Health Organisation and March of Dimes Birth Defects Foundation Partnership
Scheme World Health Organization and March of Dimes Birth Defects Foundation Partnership
Role Lead
Funding Start 2008
Funding Finish 2009
GNo
Type Of Funding C3220 - International Philanthropy
Category 3220
UON N

Perinatal Genomics Research Group$105,000

Funding body: Australian Women and Children's Research Foundation

Funding body Australian Women and Children's Research Foundation
Scheme Capacity Building Grant
Role Lead
Funding Start 2008
Funding Finish 2011
GNo
Type Of Funding C1700 - Aust Competitive - Other
Category 1700
UON N

Echosens Firbroscan Device with Standard Probe FS-502E$0

Funding body: National Health & Medical Research Council

Funding body National Health & Medical Research Council
Scheme Equipment Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON N

20071 grants / $430,894

Gene-Environment Interactions Underlying the Developmental Origins of Health and Disease$430,894

Funding body: Canadian Institute of Health Research

Funding body Canadian Institute of Health Research
Scheme Project Grant - Canada
Role Investigator
Funding Start 2007
Funding Finish 2010
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20063 grants / $574,362

A Murine Model to Investigate the Mechanisms Underlying Developmental Origins of Health and Disease$373,673

Funding body: Canadian Institute of Health Research

Funding body Canadian Institute of Health Research
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2009
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Identifying Genetic Markers of Periodontal Disease-Assciated Preterm Birth$185,689

Funding body: Raine Medical Research Foundation

Funding body Raine Medical Research Foundation
Scheme Project Grant
Role Lead
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding C1700 - Aust Competitive - Other
Category 1700
UON N

The effect of early life stress on adolescent HPA function and mental health$15,000

Funding body: Women and Infants Research Foundation

Funding body Women and Infants Research Foundation
Scheme Priming Grant
Role Investigator
Funding Start 2006
Funding Finish 2007
GNo
Type Of Funding C1700 - Aust Competitive - Other
Category 1700
UON N

20051 grants / $390,914

The Diagnosis of True Preterm Labour$390,914

Funding body: The March of Dimes Birth Defects Foundation

Funding body The March of Dimes Birth Defects Foundation
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2008
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20041 grants / $175,895

The Diagnosis of True Preterm Labour$175,895

Funding body: The Physicians Services Incorporated Foundation Toronto

Funding body The Physicians Services Incorporated Foundation Toronto
Scheme The Physicians Services Incorporated Foundation Toronto
Role Lead
Funding Start 2004
Funding Finish 2006
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20011 grants / $45,000

Induction of Labour with an Unfavourable Cervix: The Balloon Trial$45,000

Funding body: Women and Infants Research Foundation

Funding body Women and Infants Research Foundation
Scheme Preterm Birth Preventive Project Grant
Role Lead
Funding Start 2001
Funding Finish 2003
GNo
Type Of Funding C1700 - Aust Competitive - Other
Category 1700
UON N

20001 grants / $25,000

Fetal Monitoring in the Growth Restricted Ovine Fetus$25,000

Funding body: Australian Women and Children's Research Foundation

Funding body Australian Women and Children's Research Foundation
Scheme Project Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON N

19991 grants / $20,000

Biochemical and Physiologic Predictors of Neuronal Injury after Repeated Cord Occlusion in the Sheep Fetus Australian Women and Children's Research Foundation$20,000

Funding body: Australian Women and Children's Research Foundation

Funding body Australian Women and Children's Research Foundation
Scheme Project Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON N
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Research Supervision

Number of supervisions

Completed8
Current3

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2019 Honours Does the Hypothalamic-Pituitary-Adrenal Axis mediate the relationship between birth weight and adult cardiometabolic outcomes? Epidemiology, The University of Newcastle Principal Supervisor
2015 PhD Pregnancy related Medical Services and Perinatal Outcomes in Migrants Public Health, The University of Western Australia Co-Supervisor
2012 PhD Stress exposure from pregnancy to adolescence, the HPA - axis and the development of depression and anxiety in Adulthood. Psychology, Curtin University Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2017 PhD Development of an Early Life Risk Stratificatiob Tool to Facilitate Primary Prevention of the Metabolic Syndrome by Infant Nutritional Invention Obstetrics & Gynaecology, The University of Western Australia Co-Supervisor
2015 PhD Understanding the Genetic Factors Underlying the development Origins of Hypertension Genetics, The University of Western Australia Co-Supervisor
2014 Masters Subsequent Pregnancy Outcome - a retrospective analysis in Women with Previous Previable Preterm Deliveries at 16 to 24 weeks' Gestation Obstetrics & Gynaecology, Institution of Clinical Science, Department of Obstetrics and Gynaecology, King Edward Memorial Hospital for Women, Perth Co-Supervisor
2014 Masters Previable preterm birth and late miscarriage: Are they clinically distinct? Obstetrics & Gynaecology, University of Gothenburg Principal Supervisor
2013 PhD Modelling complex longitudinal Phenotypes over childhood in Genetics Association Studies Statistics, The University of Western Australia Co-Supervisor
2012 PhD Evaluation of the Utilisation, barriers and introduction of universal umbilical cord blood gas/or lactate analysis at delivery into metropolitan and regional Western Australian Maternity units. Obstetrics & Gynaecology, The University of Western Australia Co-Supervisor
2010 Masters Th physical and psycho-social impact of dysmenorrhoea in an adolescent birth cohort in Western Australia Epidemiology, Raine Study University of Western Australia Co-Supervisor
2008 PhD Gene-environment Interactions Underlying the Developmental Origins of Health and Disease Epidemiology, University of Toronto Co-Supervisor
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Research Projects

Preterm Birth Prediction and Prevention 2018 -

PredictPTL is a RNA based test developed to identify women with threatened preterm labour who will deliver within 48 hours. The test is currently undergoing pre-clinical evaluation in a collaboration with the University of Toronto and the Beijing Genomics Institute. 

PredictPTB is an RNA based test developed to identify women who have an increased risk of preterm birth. Discovery data indicate an 86% accuracy as early as 18 weeks gestation.  A version of this test, designed specifically for use in women at increased risk of preterm birth, is currently under development.

PreventPTB is an RNA based test developed to evaluate a woman’s response to preterm birth prevention treatments (cervical tracking, progesterone or cervical cerclage). A proof of principle study is currently underway.


[1] Heng YJ, Pennell CE, Chua HN, et al. Whole blood gene expression profile associated with spontaneous preterm birth in women with threatened preterm labor. PLoS One 2014;9(5):e96901. doi: 10.1371/journal.pone.0096901 [published Online First: 2014/05/16]

 

[2] Heng YJ, Pennell CE, McDonald SW, et al. Maternal Whole Blood Gene Expression at 18 and 28 Weeks of Gestation Associated with Spontaneous Preterm Birth in Asymptomatic Women. PLoS One 2016;11(6):e0155191. doi: 10.1371/journal.pone.0155191 [published Online First: 2016/06/23]


Preterm Birth Genome Project 2007 -

The Preterm Birth Genome Project (PGP)

 The PGP was initiated in response to a global call to action, in collaboration with the World Health Organisation. The Project aims to identify genetic variants associated with preterm birth. This will enable the pre-pregnancy evaluation of a woman’s genetic risk of preterm birth and will also identify potential treatment targets. This project has five phases. Phase One is now complete and established the optimal processes for the practical execution of this multinational project. Phase Two conducted a genome-wide association study (GWAS) for early, spontaneous preterm birth in Caucasian women. The current, NHMRC funded, phase is developing a custom genetic array that is tailored to preterm birth, and suitable for use in a diverse population. Analyses of these data are currently underway.

 


[1] Pennell CE, Vadillo-Ortega F, Olson DM, et al. Preterm Birth Genome Project (PGP) -- validation of resources for preterm birth genome-wide studies. J Perinat Med 2013;41(1):45-9. doi: 10.1515/jpm-2012-0145 [published Online First: 2012/10/26]

[2] Manuscript under development.


Developmental Origins of Health and Disease (DOHaD) 2018 -

The Developmental Origins of Health and Disease is a key element of my research portfolio. Utilising data from the Western Australian Pregnancy Cohort (Raine) Study, a large, densely phenotype pregnancy cohort, I participate in 13 multinational research consortia to identify the genomic antecedents of a broad range of health and disease outcomes. 

In 2019, Newcastle1000 was established. New1000 is a prospective longitudinal cohort study punctuated by intervention studies. This study will recruit 1000 Newcastle families per year in early pregnancy and follow them for life. Intensive review will be undertaken in the first 1000 days after conception, the window when interventions have the opportunity to put individuals on trajectories for lifelong health. The first intervention study focused on early nutrition is planned to begin in 2020.


Stillbirth 2018 -

In collaboration with Red Nose (formerly SIDS and KIDS), I have led research into stillbirth; specifically, this research is focused on the increased incidence of stillbirth in migrants. This is particularly timely, given the unprecedented rate of migration (latest estimated indicate that there are currently one billion migrants). This research has identified previously unrecognised patterns in stillbirth, and potential methods of reducing the risk of stillbirth for migrant mothers.


Clinical Maternal Fetal Medicine 2018 -

I have a particular interest in late miscarriage and previable preterm birth; most my patients have experienced the loss of at least one pregnancy. I have conducted a review of every late miscarriage/previable preterm birth (16-24 weeks n~5000) over a ten-year period including evaluating their subsequent pregnancies. Similarly, I have a special interest in preterm birth prevention, the management of pregnancy following stillbirth, and the optimisation of pre-conception counselling.


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News

Prof Craig Pennell appointed Chair of Red Nose Group

July 2, 2018

University of Newcastle’s Professor Craig Pennell, is the newly appointed Chair of the Red Nose National Scientific Advisory Group.

Professor Craig Pennell

Position

Chair of Obstetrics and Gynecology
Maternity and Gynaecology
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email craig.pennell@newcastle.edu.au
Phone (02) 40420546
Mobile 0421941570
Links Research Networks
Research Networks

Office

Room Level 3, 3018
Building HMRI
Location Hunter Medical Research Institute

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