Dr Jonathan Paul
Lecturer
School of Medicine and Public Health (Reproductive Medicine)
- Email:jonathan.paul@newcastle.edu.au
- Phone:(02) 4042 0348
Targeting better outcomes for mothers and babies
An emerging leader in the field of reproductive medicine, Dr Jonathan Paul has been internationally recognised for his work on targeting therapeutic nanoparticles to the muscle cells of the uterus.
THE DELIVERY SUITE
Dr Jonathan Paul is a member of a team of multidisciplinary researchers at the University of Newcastle's Mothers and Babies Research Centre, who work to determine the cause, and most effective therapeutic approach, to maternal, foetal and neonatal health problems in humans.
The post-doctoral scientist is applying his expertise to a new mode of medication delivery to the uterus, which has the potential to radically decrease risks related to childbirth.
Jonathan is part of a team with a revolutionary drug delivery vector that has the capacity to increase the effectiveness of targeted therapeutics, potentially resulting in: halting pre-term labour, inducing or accelerating non-productive labour, or stemming postpartum bleeding.
The unique system has garnered Jonathan much attention due to the potential to save countless lives before, during and after childbirth. In early 2015, Jonathan was awarded the Presidential New Investigators Award by the Society for Reproductive Investigation at their 62nd Annual Meeting in San Francisco.
THE CELL EXPRESS
Jonathan completed his PhD as a member of the Reproductive Science Group at the University of Newcastle, focusing on proteins expressed on the surface of ova and their relevance to sperm ova interaction.
Jonathan then joined the Mothers and Babies team to undertake analysis of the protein changes that occur during the transition of uterine cells from quiescence to contractility. His skill in the lab has secured his involvement in many projects within the Centre.
Jonathan's primary research focus is the development of a targeted drug delivery system for the uterus, which is a successful project collaboration between the Mothers and Babies Research Centre Director, Professor Roger Smith, and Dr Susan Hua, head of the Therapeutic Targeting Research Group in the Discipline of Pharmacy. The collaboration draws upon the valuable skills of Susan in manufacturing the specialised targeted liposomes, and couples her expertise with Jonathan and Roger's research interests in reproductive medicine. Jonathan then uses his expertise in the lab to apply the drug delivery system to both human and animal models.
The uterus is one of the organs in the body that is made of smooth muscle. Currently, medications administered to stimulate or relax the uterus have been designed for use in other areas of the body. As such, they can have off-target affects, limiting both the range of drugs that can be administered safely, and the effectiveness of those chosen drugs.
Jonathan's new system targets a particular protein, ensuring the medication is directed specifically to the uterus.
A SPOONFUL OF NANOPARTICLES
Liposomes (tiny bubbles made from the same material as a cell membrane) deliver the medication by seeking out specific proteins. Jonathan explains:
"Our cells are surrounded by a membrane. We take a small section of artificial membrane, make a tiny sphere, encapsulate the drug inside that sphere, then we target that sphere to the uterus."
"What we have done is to look for a particular protein that is expressed in high abundance only on uterine cells. We've then targeted the liposomes to that protein."
This targeted delivery system has the following benefits: it increases the effectiveness of existing medication; and offers the possibility of utilising drugs previously considered unsafe due to affects on other organs and tissues.
RIGHT ON TARGET
Complications related to childbirth create considerable short and long term strains on mother and baby, as well as the health care system. There are several stages of pregnancy and labour that present a danger, especially in less developed countries.
Pre-term birth is the major cause of neo-natal morbidity and mortality, and is responsible for more than half the cases of cerebral palsy. Pre-term infants who survive can be left with on-going complications such as asthma, eye or hearing problems, and increased long-term risk of developing several conditions such as diabetes and heart disease.
If a pregnancy approaches 42 weeks a caesarian section will be performed to counter the increased risk of intra-uterine death. This resource intensive procedure may discourage the mother from giving birth naturally in future deliveries. In less developed countries, a c-section may not be an option.
If the uterus fails to contract following delivery, post-partum hemorrhage may result. In less developed countries, where there is limited or no access to medicines such as oxytocin (which promotes contractions and the restriction of blood vessels), excessive blood loss can result in death.
Using the targeted drug delivery system, liposomes could be filled with medication aimed at maximising uterine contraction, thus restricting the body's ability to lose blood. When a pregnancy has continued past 42 weeks, the liposomes could be loaded with medication aimed at stimulating or increasing contractility. If pre-term labour has begun, the liposomes would be loaded with medication to halt contractions.
PROGRESSING TO TERM
Jonathan has achieved great success trialing the delivery system on uterine tissue harvested during myometrium biopsies. Further research using a mouse model is underway.
A major cause of pre-term labour in women is inflammation arising from bacterial infection. Accordingly, infection is being simulated to test how effectively the targeted delivery system can work to halt contractions when pre-term labour occurs due to bacterial infection.
Progesterone withdrawal is another leading cause of pre-term labour, as it is essential to the maintenance of a pregnancy. Further research will be undertaken through a mouse model, to measure the efficacy of the targeted delivery system in the event of withdrawal of progesterone.
"The therapeutics we are looking at using target the raw mechanism of the contraction," says Jonathan.
"Regardless of what signaling events are occurring upstream, if we can disable that pathway and eliminate the ability of the cell to undergo the fundamentals of contractility, we should be able to block pre-term labour."
Assuming the success of the mouse model trials, the next step would be to test the efficacy of the system using a primate model. Jonathan hopes to eventually work in collaboration with the University of Washington's Infant Primate Research Laboratory within their Centre on Human Development and Disability.
PRO-TEAM PROTEIN
It is already clear that the drug delivery vector could be adapted to target cells in other areas of the body.
"You could target any number of tissues provided it has a specific marker. In this case, Roger, Susan and I have used it to target the uterus, but it certainly has a much bigger scope than that," Jonathan explains.
"If you have a cancer, for instance, that expresses a particular protein in high abundance relative to any other tissues or organs, then you could target liposomes to those cancer cells."
Another area of research that is currently moving forward using the targeted delivery system is a project to fight ovarian cancer.
"I'm working with another post-doc, Dr Jorge Tolosa, with input from Roger Smith on this project. Susan Hua, who manufactures the liposomes, also has her own applications for targeted liposomes that are specific for her field of interest," explains Jonathan.
Completed trials suggest that the drug delivery vector is an acutely superior system when it comes to concentrating medication in the goal area.
Whether the targeted liposomes are stopping pre-term labour or attacking uterine cancer cells, this new system has the potential to save countless lives, and revolutionise the way therapeutics are delivered.
Targeting better outcomes for mothers and babies
An emerging leader in the field of reproductive medicine, Dr Jonathan Paul has been internationally recognised for his work on targeting therapeutic nanoparti
Career Summary
Biography
PhD Opportunity: The Mothers and Babies Research Centre is seeking candidates interested in undertaking a PhD on the novel application of 3D tissue culture to reproductive medicine. The project will build upon work by a current student nearing completion, and seeks to apply 3D culture and tissue engineering techniques to improve in vitro studies into human uterine smooth muscle.
Please see the 'Opportunities' tab for further details on PhD opportunities.
Dr. Paul completed his PhD within the Reproductive Sciences Group under the leadership of Professor Eileen McLaughlin and Laureate Professor John Aitken. Dr. Paul then joined the Mothers and Babies Research Centre where he has dedicated his research to elucidating the mechanisms behind human parturition and the onset of labour.
Dr. Paul has a background in proteomics, and more recently has specialised in phospho-proteomics and how these techniques can be applied to elucidating changes associated with the onset of labour.
“My research focuses on understanding the physiological changes that occur late in human pregnancy. I am particularly interested in elucidating the changes in uterine smooth muscle cells that are responsible for transforming a quiescent, non-contractile uterus, capable of expanding to accommodate a growing fetus, into an actively contracting muscular organ that is engaged in powerful synchronised contractions in order to deliver the foetus."
Recently, Dr. Paul’s research has focused on the development of a targeted drug delivery system for the uterus. Dr. Paul is part of a research team that has developed ‘targeted liposomes’, a type of organic nanoparticle capable of carrying a drug payload, as a means targeting therapeutic interventions specifically to the uterus.
Dr. Paul’s research into the awakening of uterine smooth muscle cells and targeted drug delivery to the uterus is ongoing, and has served as the platform for patents, on which he is a named inventor.
Qualifications
- PhD (Biological Science), University of Newcastle
- Bachelor of Biotechnology, University of Newcastle
- Bachelor of Biotechnology (Honours), University of Newcastle
Keywords
- labour
- myometrium
- nanomedicine
- pregnancy
- preterm birth
- proteomics
- reproductive medicine
- smooth muscle contraction
- targeted drug delivery
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 110199 | Medical Biochemistry and Metabolomics not elsewhere classified | 20 |
| 111499 | Paediatrics and Reproductive Medicine not elsewhere classified | 60 |
| 060109 | Proteomics and Intermolecular Interactions (excl. Medical Proteomics) | 20 |
Professional Experience
UON Appointment
| Title | Organisation / Department |
|---|---|
| Lecturer | University of Newcastle School of Medicine and Public Health Australia |
Awards
Award
| Year | Award |
|---|---|
| 2015 |
The Presidential New Investigator Award Society of Reproductive Investigation |
| 2001 |
Don Angus Memorial Award The University of Newcastle - Faculty of Science and IT |
Patents
| Number | Title | Patent Family | Registered | Approved |
|---|---|---|---|---|
| WO 2014186843 A1 |
Targeted delivery of drugs to the myometrium A mechanism for achieving the targeted delivery of therapeutic agents to the pregnant uterus, whether for the enhancement of uterine contractions or for the inhibition of uterine contractions. |
Standard | 23/5/2014 | 2014 |
Prestigious works / other achievements
| Year Commenced | Year Finished | Prestigious work / other achievement | Role |
|---|---|---|---|
| 2015 | 2015 | HMRI Thru The Lens: A Culture for Success Hunter Medical Research Institute | Artist |
| 2015 | 2015 | Video Publication: The Heart is Like an Orchestra, the Uterus is Like a Soccer Crowd Online | Designer |
| 2014 | 2014 | ABC OPEN: Snapped at Work abc.net.au | Artist |
| 2014 | 2014 | HMRI Through the Video Lens: Come Science With Me Hunter Medical Research Institute | Creator |
| 2013 | 2013 | HMRI Thru The Lens: Cloning at HMRI Hunter Medical Research Institute | Artist |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (4 outputs)
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| 2020 |
Phung J, Paul J, Smith R, 'Maintenance of Pregnancy and Parturition', Maternal-Fetal and Neonatal Endocrinology, Elsevier., Philadelphia, PA, USA 169-187 (2020)
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| 2018 |
Ilicic M, Paul JW, 'Methods and model systems used to study pregnant human uterine smooth muscle', Muscle Cell and Tissue, InTechOpen, London, UK 309-335 (2018) [B1]
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| 2013 |
Smith R, Paul J, Chan C, Keelan J, 'The role of the primate placenta in term and preterm parturition', The Placenta: Development, Function and Diseases, Nova Science, Hauppaugue, NY 335-346 (2013) [B1]
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| 2012 |
Schjenken JE, Tolosa Gonzalez JM, Paul JW, Clifton VL, Smith R, 'Mechanisms of maternal immune tolerance during pregnancy', Recent Advances in Research on the Human Placenta, InTech, Rijeka, Croatia 211-242 (2012) [B1]
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Journal article (34 outputs)
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| 2020 |
Paul JW, Kemsley JO, Butler TA, Tolosa JM, Thompson MB, Smith R, Whittington CM, 'A comparison of uterine contractile responsiveness to arginine vasopressin in oviparous and viviparous lizards', Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, 190 49-62 (2020) [C1] © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Nonapeptides and their receptors regulate a diverse range of physiological processes. We assessed the contractile re... [more] © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Nonapeptides and their receptors regulate a diverse range of physiological processes. We assessed the contractile responsiveness of uteri from the squamate viviparous-oviparous species pair, Pseudemoia entrecasteauxii and Lampropholis guichenoti, as well as the bimodally reproductive species, Saiphos equalis, to arginine vasopressin (AVP). We assessed the resulting uterine contractility as a function of pregnancy status, species and parity mode. We also measured mRNA abundance for the nonapeptide receptor, oxytocin receptor (oxtr), in uteri from P. entrecasteauxii and L. guichenoti and compared expression across pregnancy status and parity mode. We found that pregnant uteri exhibited a significantly greater contractile response to AVP than non-pregnant uteri in all three lizard species studied. Cross-species comparisons revealed that uteri from viviparous P. entrecasteauxii were significantly more responsive to AVP than uteri from oviparous L. guichenoti during both pregnant and non-pregnant states. Conversely, for non-pregnant S. equalis, uteri from viviparous individuals were significantly less responsive to AVP than uteri from oviparous individuals, while during pregnancy, there was no difference in AVP contractile responsiveness. There was no difference in expression of oxtr between L. guichenoti and P. entrecasteauxii, or between pregnant and non-pregnant individuals within each species. We found no significant correlation between oxtr expression and AVP contractile responsiveness. These findings indicate that there are differences in nonapeptide signalling across parity mode and suggest that in these lizards, labour may be triggered either by an increase in plasma nonapeptide concentration, or by an increase in expression of a different nonapeptide receptor from the vasopressin-like receptor family.
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| 2020 |
Smith R, Paul JW, Tolosa JM, 'Sharpey-Schafer Lecture 2019: From retroviruses to human birth', Experimental Physiology, 105 555-561 (2020) [C1] © 2019 The Authors. Experimental Physiology © 2019 The Physiological Society New Findings: What is the topic of this review? The timing of birth is an important determinant of fut... [more] © 2019 The Authors. Experimental Physiology © 2019 The Physiological Society New Findings: What is the topic of this review? The timing of birth is an important determinant of future health and well-being. This review examines the role of endogenous retroviruses as upstream regulators of key biological functions of the placenta, including cell-cell fusion, modulation of the maternal immune system, and the production of key pregnancy hormones. What advances does it highlight? Endogenous retroviruses are an obligate requirement for successful human reproduction. The products of retroviral elements, incorporated into the germline millions of years ago, have been co-opted to serve vital biological roles within the placenta that ultimately dictate the length of human pregnancy and therefore well-being trajectories. Abstract: Gestational length at the time of birth is an important determinant of future health and well-being, yet the physiological regulation of the onset of labour in humans remains obscure. The evolution of egg formation and internal fertilisation in amniotes required a mechanism to suppress the contractile activity of the oviduct that is provided by progesterone. Delivery of the egg is then associated with the withdrawal of progesterone and a return of contractile activity to the reproductive tract. In mammals, the process of pregnancy is complicated further by the need to protect the fetus from potential attack by the maternal immune system. There is increasing evidence that retroviruses incorporated into the mammalian germline in the evolutionary past play a key role in suppressing the maternal immune reaction to the developing conceptus, organising the development of the placenta and perhaps, in humans, modulating the action of progesterone, determining gestational length and the onset of labour. It seems that the presence of an endogenous retrovirus is an obligate requirement for human reproduction.
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| 2020 |
Butler TA, Paul JW, Smith R, 'Non-conventional signalling in human myometrium by conventional pathways: looking back for a synergistic future', Current Opinion in Physiology, 13 145-154 (2020) [C1] © 2019 The mechanisms that bring about the onset of labor in humans remain poorly understood. Previous research has extensively explored signalling pathways that maintain myometri... [more] © 2019 The mechanisms that bring about the onset of labor in humans remain poorly understood. Previous research has extensively explored signalling pathways that maintain myometrial relaxation and identified roles for key molecules, including cyclic nucleotides, nitric oxide, carbon monoxide, hydrogen sulfide and progesterone. However, these conventional pro-relaxation signalling pathways have fallen out of favor to inflammatory signalling, which is now widely regarded as an instigator of myometrial transformation toward a contractile phenotype and initiator of labor. This article revisits the complex inter-play of conventional pro-relaxation signalling, and explores the concept that progesterone, cAMP, glucocorticoids, and possibly gasotransmitters, work in synergy to constitute a uterine brake that suspends the intrinsic contractility of the myometrium, thus enabling retention of the conceptus and the progression of pregnancy. As term approaches, this uterine brake of relaxatory signalling is ultimately withdrawn, thus permitting restoration of myometrial contractility and culminating in the initiation of labor.
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| 2020 |
Ilicic M, Zakar T, Paul J, 'The Regulation of Uterine Function During Parturition: An Update and Recent Advances', Reproductive Sciences, 27 3-28 (2020) [C1]
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| 2020 |
Rowe CW, Dill T, Griffin N, Jobling P, Faulkner S, Paul JW, et al., 'Innervation of papillary thyroid cancer and its association with extra-thyroidal invasion', Scientific Reports, 10 (2020) [C1]
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| 2019 |
Rowe CW, Faulkner S, Paul JW, Tolosa JM, Gedye C, Bendinelli C, et al., 'The precursor for nerve growth factor (proNGF) is not a serum or biopsy-rinse biomarker for thyroid cancer diagnosis.', BMC endocrine disorders, 19 128 (2019) [C1]
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| 2019 |
Rowe CW, Dill T, Faulkner S, Gedye C, Paul JW, Tolosa JM, et al., 'The precursor for nerve growth factor (ProNGF) in thyroid cancer lymph node metastases: Correlation with primary tumour and pathological variables', International Journal of Molecular Sciences, 20 1-13 (2019) [C1]
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| 2019 |
Ilicic M, Zakar T, Paul JW, 'Epigenetic regulation of progesterone receptors and the onset of labour', Reproduction, Fertility and Development, 31 1035-1048 (2019) [C1] © 2019 CSIRO. Progesterone plays a crucial role in maintaining pregnancy by promoting myometrial quiescence. The withdrawal of progesterone action signals the end of pregnancy and... [more] © 2019 CSIRO. Progesterone plays a crucial role in maintaining pregnancy by promoting myometrial quiescence. The withdrawal of progesterone action signals the end of pregnancy and, in most mammalian species, this is achieved by a rapid fall in progesterone concentrations. However, in humans circulating progesterone concentrations remain high up to and during labour. Efforts to understand this phenomenon led to the 'functional progesterone withdrawal' hypothesis, whereby the pro-gestation actions of progesterone are withdrawn, despite circulating concentrations remaining elevated. The exact mechanism of functional progesterone withdrawal is still unclear and in recent years has been the focus of intense research. Emerging evidence now indicates that epigenetic regulation of progesterone receptor isoform expression may be the crucial mechanism by which functional progesterone withdrawal is achieved, effectively precipitating human labour despite high concentrations of circulating progesterone. This review examines current evidence that epigenetic mechanisms play a role in determining whether the pro-gestation or pro-contractile isoform of the progesterone receptor is expressed in the pregnant human uterus. We explore the mechanism by which these epigenetic modifications are achieved and, importantly, how these underlying epigenetic mechanisms are influenced by known regulators of uterine physiology, such as prostaglandins and oestrogens, in order to phenotypically transform the pregnant uterus and initiate labour.
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| 2019 |
Butler T, Paul J, Chan E-C, Smith R, Tolosa Gonzalez JM, 'Misleading Westerns: Common Quantification Mistakes in Western Blot Densitometry and Proposed Corrective Measures', BioMed Research International, 2019 (2019) [C1]
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| 2018 |
Paul JW, Smith R, 'Preventing Preterm Birth: New Approaches to Labour Therapeutics using Nanoparticles', BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 52 48-59 (2018) [C1]
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| 2018 |
Heslop B, Drew A, Stojanovski E, Bailey K, Paul JW, 'Collaboration Vouchers: A Policy to Increase Population Wellbeing', Societies, 8 (2018) [C1]
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| 2018 |
Heslop B, Bailey K, Paul JW, Stojanovski E, 'The PILAR Model as a Measure of Peer Ratings of Collaboration Viability in Small Groups', Social Sciences, 7 1-14 (2018) [C1]
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| 2018 |
Heslop B, Paul J, Stojanovski E, Bailey K, 'Organisational Psychology and Appreciative Inquiry: Unifying the Empirical and the Mystical', AI Practitioner, 20 69-90 (2018) [C1]
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| 2018 |
Heslop B, Stojanovski E, Paul JW, Bailey K, 'PILAR: A Model of Collaboration to Encapsulate Social Psychology', Review of General Psychology, 22 321-333 (2018) [C1]
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| 2018 |
Heslop B, Stojanovski E, Iverson S, Paul JW, Bailey K, 'Respondent disengagement from a peer assessment instrument measuring Collaboration Viability', Australasian Journal of Engineering Education, 22 95-106 (2018) [C1]
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| 2017 |
Ilicic M, Butler T, Zakar T, Paul JW, 'The expression of genes involved in myometrial contractility changes during ex situ culture of pregnant human uterine smooth muscle tissue', Journal of Smooth Muscle Research, 53 73-89 (2017) [C1] © 2017 The Japan Society of Smooth Muscle Research. Background: Ex situ a nalyses of human myometrial t issue h as b een u sed t o i nvestigate t he r egulation of uterine quiesce... [more] © 2017 The Japan Society of Smooth Muscle Research. Background: Ex situ a nalyses of human myometrial t issue h as b een u sed t o i nvestigate t he r egulation of uterine quiescence and transition to a contractile phenotype. Following concerns about the validity of cultured primary cells, we examined whether myometrial tissue undergoes culture-induced changes ex situ that may affect the validity of in vitro models. Objectives: To determine whether human myometrial tissue undergoes culture-induced changes ex situ in Estrogen receptor 1 (ESR1), Prostaglandin-endoperoxide synthase 2 (PTGS2) and Oxytocin receptor (OXTR) expression. Additionally, to determine whether culture conditions approaching the in vivo environment influence the expression of these key genes. Methods: Term non-laboring human myometrial tissues were cultured in the presence of specific treatments, including; serum supplementation, progesterone and estrogen, cAMP, PMA, stretch or NF-¿B inhibitors. ESR1, PTGS2 and OXTR mRNA abundance after 48 h culture was determined using quantitative RT-PCR. Results: Myometrial tissue in culture exhibited culture-induced up-regulation of ESR1 and PTGS2 and down-regulation of OXTR mRNA expression. Progesterone prevented culture-induced increase in ESR1 expression. Estrogen further up-regulated PTGS2 expression. Stretch had no direct effect, but blocked the effects of progesterone and estrogen on ESR1 and PTGS2 expression. cAMP had no effect whereas PMA further up-regulated PTGS2 expression and prevented decline of OXTR expression. Conclusion: Human myometrial tissue in culture undergoes culture-induced gene expression changes consistent with transition toward a laboring phenotype. Changes in ESR1, PTGS2 and OXTR expression could not be controlled simultaneously. Until optimal culture conditions are determined, results of in vitro experiments with myometrial tissues should be interpreted with caution.
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| 2017 |
Rowe CW, Paul JW, Gedye C, Tolosa JM, Bendinelli C, McGrath S, Smith R, 'Targeting the TSH receptor in thyroid cancer', Endocrine-Related Cancer, 24 R191-R202 (2017) [C1] © 2017 Society for Endocrinology Printed in Great Britain. Recent advances in the arena of theranostics have necessitated a re-examining of previously established fields. The exis... [more] © 2017 Society for Endocrinology Printed in Great Britain. Recent advances in the arena of theranostics have necessitated a re-examining of previously established fields. The existing paradigm of therapeutic thyroid-stimulating hormone receptor (TSHR) targeting in the post-surgical management of differentiated thyroid cancer using levothyroxine and recombinant human thyroid-stimulating hormone (TSH) is well understood. However, in an era of personalized medicine, and with an increasing awareness of the risk profile of longstanding pharmacological hyperthyroidism, it is imperative clinicians understand the molecular basis and magnitude of benefit for individual patients. Furthermore, TSHR has been recently re-conceived as a selective target for residual metastatic thyroid cancer, with pilot data demonstrating effective targeting of nanoparticles to thyroid cancers using this receptor as a target. This review examines the evidence for TSHR signaling as an oncogenic pathway and assesses the evidence for ongoing TSHR expression in thyroid cancer metastases. Priorities for further research are highlighted.
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| 2017 |
Ilicic M, Zakar T, Paul JW, 'Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium', BIOMED RESEARCH INTERNATIONAL, 2017 (2017) [C1]
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| 2017 |
Paul JW, Hua S, Ilicic M, Tolosa JM, Butler T, Robertson S, Smith R, 'Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 216 (2017) [C1]
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| 2017 |
Heidari Kani M, Chan EC, Young RC, Butler T, Smith R, Paul JW, '3D Cell Culturing and Possibilities for Myometrial Tissue Engineering', Annals of Biomedical Engineering, 45 1746-1757 (2017) [C1] © 2016, Biomedical Engineering Society. Research insights into uterine function and the mechanisms of labour have been hindered by the lack of suitable animal and cellular models.... [more] © 2016, Biomedical Engineering Society. Research insights into uterine function and the mechanisms of labour have been hindered by the lack of suitable animal and cellular models. The use of traditional culturing methods limits the exploration of complex uterine functions, such as cell interactions, connectivity and contractile behaviour, as it fails to mimic the three-dimensional (3D) nature of uterine cell interactions in vivo. Animal models are an option, however, use of these models is constrained by ethical considerations as well as translational limitations to humans. Evidence indicates that these limitations can be overcome by using 3D culture systems, or 3D Bioprinters, to model the in vivo cytological architecture of the tissue in an in vitro environment. 3D cultured or 3D printed cells can be used to form an artificial tissue. This artificial tissue can not only be used as an appropriate model in which to study cellular function and organisation, but could also be used for regenerative medicine purposes including organ or tissue transplantation, organ donation and obstetric care. The current review describes recent developments in cell culture that can facilitate the development of myometrial 3D structures and tissue engineering applications.
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| 2017 |
Paul JW, ilicic M, zakar T, smith R, 'Expression of KCNH2 (hERG1) and KCNE2 Correlates With Expression of Key Myometrial Genes in Term Pregnant Human Myometrium', Journal of Human Endocrinology, 2 (2017) [C1]
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| 2016 |
Heslop B, Bailey K, Paul JW, Drew AJ, Smith R, 'Collaboration Guidelines to Transform Culture', Interdisciplinary Journal of Partnership Studies, 3 1-25 (2016) [C1]
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| 2015 |
Smith R, Imtiaz M, Banney D, Paul JW, Young RC, 'Why the heart is like an orchestra and the uterus is like a soccer crowd', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 213 181-185 (2015) [C1]
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| 2015 |
Banney D, Young R, Paul JW, Imtiaz M, Smith R, 'A hypothesis for self-organization and symmetry reduction in the synchronization of organ-level contractions in the human uterus during labor', Symmetry, 7 1981-1988 (2015) [C1] © 2015 by the authors. We present a hypothesis for a mechanism involving self-organization of small functional units that leads to organ-level synchronization of uterine contracti... [more] © 2015 by the authors. We present a hypothesis for a mechanism involving self-organization of small functional units that leads to organ-level synchronization of uterine contractions in human labor. This view is in contrast to the long-held presumption that the synchronized behavior of the uterus is subject to well-defined internal organization (as is found in the heart) that exists prior to the onset of labor. The contractile units of the uterus are myocytes, which contract in response to both mechanical stretch and electrical stimulation. Throughout pregnancy progesterone maintains quiescence by suppression of "contraction-associated proteins" (CAPs). At the end of pregnancy a functional withdrawal of progesterone and an increasingly estrogenic environment leads to an increase in the production of CAPs. One CAP of particular importance is connexin 43, which creates gap junctions between the myocytes that cause them to become electrically coupled. The electrical connectivity between myocytes, combined with an increase in intrauterine pressure at the end of pregnancy shifts the uterus towards an increasingly unstable critical point, characterized by irregular, uncoordinated contractions. We propose that synchronous, coordinated contractions emerge from this critical point through a process of self-organization, and that the search for a uterine pacemaker has been unfruitful for the sole reason that it is non-existent.
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| 2014 |
Parkington HC, Stevenson J, Tonta MA, Paul J, Butler T, Maiti K, et al., 'Diminished hERG K Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action pot... [more] Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (a-conducting and ßinhibitory subunits) and hERG currents exist in isolated patch-clamped human myometrial cells. We show that hERG channel activity suppresses contraction amplitude and duration before labour, thereby facilitating quiescence. During established labour, expression of ß-inhibitory protein is markedly enhanced, resulting in reduced hERG activity that is associated with an increased duration of uterine action potentials and contractions. Thus, changes in hERG channel activity contribute to electrophysiological mechanisms that produce contractions during labour. We also demonstrate that this system fails in women with elevated BMI, who have enhanced hERG activity as a result of low ß-inhibitory protein expression, which likely contributes to the weak contractions and poor labour outcomes observed in many obese women necessitating caesarean delivery. © 2014 Macmillan Publishers Limited.
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| 2013 |
Butler T, Paul J, Europe-Finner N, Smith R, Chan E-C, 'Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 304 C485-C504 (2013) [C1]
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| 2012 |
Smith R, Paul JW, Maiti K, Tolosa Gonzalez JM, Madsen GM, 'Recent advances in understanding the endocrinology of human birth', Trends in Endocrinology & Metabolism, 23 516-523 (2012) [C1]
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| 2012 |
Hure AJ, Collins CE, Giles WB, Paul JW, Smith R, 'Greater maternal weight gain during pregnancy predicts a large but lean fetal phenotype: A prospective cohort study', Maternal and Child Health Journal, 16 1374-1384 (2012) [C1]
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| 2012 |
Welsh TN, Paul JW, Palliser HK, Tabatabaeehatambakhsh SH, Hirst JJ, Mesiano S, Zakar T, '15-hydroxyprostaglandin dehydrogenase expression and localization in guinea pig gestational tissues during late pregnancy and parturition', Reproductive Sciences, 19 1099-1109 (2012) [C1]
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| 2011 |
Paul JW, Maiti K, Read MA, Hure AJ, Smith JI, Chan EC, Smith R, 'Phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium', PLoS ONE, 6 1-7 (2011) [C1]
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| 2011 |
Maiti K, Paul JW, Read MA, Chan EC, Riley SC, Nahar P, Smith R, 'G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium', Endocrinology, 152 2448-2455 (2011) [C1]
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| 2005 |
Nixon B, Paul JW, Spiller CM, Attwell-Heap AG, Ashman LK, Aitken RJ, 'Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa', Journal of Cell Science, 118 4865-4877 (2005) [C1]
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Heslop B, Stojanovski E, Paul J, Bailey K, 'Are We Collaborating Yet? Employee Assessment of Peer s Perceptions', International Journal of Human Resource Studies, 7 175-175 [C1]
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| Show 31 more journal articles | |||||||||||
Conference (31 outputs)
| Year | Citation | Altmetrics | Link | ||||
|---|---|---|---|---|---|---|---|
| 2020 | Paul J, 'On Target for Novel Therapies?', Vancouver, Canada (2020) | ||||||
| 2019 |
Paul J, Hua S, Ilicic M, Tolosa Gonzalez JM, Butler T, Robertson S, Smith R, 'Preventing Preterm Birth: New Approaches to Labour Therapeutics using Nanoparticles', Las Vegas, NV, USA (2019)
|
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| 2018 |
Rowe C, Dill T, Clarke M, Paul J, Gedye C, King S, Hondermarck H, 'A methodology for validating automated digital whole-slide analysis of immunohistochemical biomarkers using open source software (QuPath).', Newcastle, Australia (2018)
|
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| 2017 |
Rowe C, King S, Tolosa J, Paul J, Gedye C, Smith R, 'Overexpression of the Sodium-Iodide Symporter in thyroid cancer co-existing with Graves disease', Perth, Western Australia (2017)
|
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| 2017 |
Rowe C, Tolosa Gonzalez JT, Faulkner S, Paul JW, Gedye C, McGrath S, et al., 'The precursor for nerve growth factor (proNGF) is detectable in the rinse of fine needle aspiration biopsy of thyroid cancer', Boston, Massachussetts (2017)
|
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| 2015 |
Paul J, Hua S, Smith R, 'A Targeted Drug Delivery System for the Uterus', REPRODUCTIVE SCIENCES (2015) [E3]
|
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| 2012 |
Parkington HC, Paul JW, Tonta MA, Chan EC, Sheehan PJ, Brennecke SP, et al., 'Human labour is associated with decreased myometrial ether-a-go-go related gene (hERG) potassium channels that modulate contractility', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]
|
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| 2012 |
Welsh TN, Paul JW, Palliser HK, Hirst JJ, Mesiano S, Zakar T, 'PGDH expression decreases at term before labor onset in guinea pig fetal membranes', Reproductive Sciences, San Diego, CA (2012) [E3]
|
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| 2011 |
Hure AJ, Collins CE, Giles WB, Paul JW, Smith R, 'A large but lean fetal phenotype is associated with greater maternal weight gain during pregnancy', Obesity Research & Clinical Practice, Adelaide (2011) [E3]
|
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| 2011 |
Paul JW, Maiti K, Read MA, Hure AJ, Smith JI, Chan EC, Smith R, 'Studying laboring myometrium misses phosphorylation changes associated with contraction', Reproductive Sciences, Miami Beach (2011) [E3]
|
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| 2010 |
Maiti K, Paul JW, Read MA, Chan EC, Smith R, 'Human labor Is associated with internalization and oligomerization of the membrane estrogen receptor, GPR30', Reproductive Sciences, Orlando, Florida (2010) [E3]
|
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| 2010 |
Maiti K, Paul JW, Chan EC, Smith R, 'GPR30, the novel membrane estrogen receptor, stimulates contractility of myometrium by increasing expression of h-caldesmon', The Endocrine Society of Australia Annual Scientific Meeting Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
|
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| 2010 |
Paul JW, Maiti K, Read MA, Smith R, 'Caldesmon phosphorylation and phasic regulation of ERK 1/2 during contractions in human myometrium', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
|
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| 2009 |
Maiti K, Paul JW, Read MA, Chan EC, Smith R, 'Demonstration that activation of the cell surface estrogen receptor GPR30 causes phosphorylation of HSP27 and MAPK p42/44 in term human myometrial tissue and explants', Reproductive Sciences, Glasgow, Scotland (2009) [E3]
|
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| 2009 |
Paul JW, Read MA, Smith R, 'Phosphorylation events associated with myometrial awakening and the development of contractile force in humans', Reproductive Sciences, Glasgow, Scotland (2009) [E3]
|
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| 2008 |
Maiti K, Paul JW, Read MA, Chan EC, Smith R, 'Presence of the novel membrane estrogen receptor G-Protein coupled receptor 30 (GPR30) a membrane estrogen receptor in human pregnant myometrium and its biochemical characterization', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, Melbourne, VIC (2008) [E3]
|
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| 2008 |
Paul JW, Read MA, Chan EC, Smith R, 'Phospho-proteomic determination of contraction associated proteins in the human uterus', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, Melbourne, VIC (2008) [E3]
|
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| 2006 |
Paul JW, Aitken RJ, McLaughlin EA, 'Oolemmal Proteomics: Characterisation of Glycophosphatidylinositol Anchored Proteins Involved in Murine Fertilisation', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
|
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| 2006 |
Nixon B, Paul JW, Spiller CM, Attwell-Heap AG, Aitken RJ, 'Evidence for the Involvement of Pecam-1 in a Reception Mediated Signal-Transduction Pathway regulating Capacitation-Associated Tyrosine Phosphorylation in Human Spermatozoa', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
|
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| 2004 |
Paul JW, McLaughlin EA, Aitken RJ, 'Oolemmal Proteomics: Identification of the Oocyte Cell Surface Protein Complexes Involved in Sperm-egg Interaction', Reproduction, Fertility and Development, Sydney (2004) [E3]
|
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| 2003 |
Nixon B, Paul JW, Aitken RJ, 'Wheat germ agglutinin induced tyrosine phosphorylation of human spermatozoa', 28th Annual Lorne Conference on Protein Structure & Function, Lorne, Victoria (2003) [E3]
|
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| 2003 |
Nixon B, Attwell-Heap AG, Paul JW, Aitken RJ, 'Wheat Germ Agglutinin Induced Tyrosine Phosphorylation of Human Spermatozoa', Reproduction, Fertility and Development, Melbourne (2003) [E3]
|
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| Show 28 more conferences | |||||||
Report (1 outputs)
| Year | Citation | Altmetrics | Link | ||
|---|---|---|---|---|---|
| 2017 |
Paul JW, Hua S, Ilicic M, Tolosa JM, Butler T, Robertson S, Smith R, 'Applying nanopharmacology to obstetrics: A novel targeted drug delivery system for the uterus', Atlas of Science, 1 (2017)
|
Grants and Funding
Summary
| Number of grants | 25 |
|---|---|
| Total funding | $2,174,595 |
Click on a grant title below to expand the full details for that specific grant.
20204 grants / $905,920
MRSP 2020 Pregnancy and Reproduction Program$425,758
Funding body: Hunter Medical Research Institute
| Funding body | Hunter Medical Research Institute |
|---|---|
| Project Team | Laureate Professor Roger Smith, Laureate Professor John Aitken, Professor Craig Pennell, Professor Lee Smith, Professor Jon Hirst, Professor Brett Nixon, Associate Professor Kirsty Pringle, Doctor Jonathan Paul, Doctor Jessie Sutherland |
| Scheme | NSW MRSP Infrastructure Grant |
| Role | Investigator |
| Funding Start | 2020 |
| Funding Finish | 2020 |
| GNo | G1901541 |
| Type Of Funding | C2220 - Aust StateTerritoryLocal - Other |
| Category | 2220 |
| UON | Y |
Development of Nanoliposome Targeting Technology$240,000
Funding body: Hunter Medical Research Institute
| Funding body | Hunter Medical Research Institute |
|---|---|
| Project Team | Laureate Professor Roger Smith, Doctor Jonathan Paul |
| Scheme | Research Grant |
| Role | Investigator |
| Funding Start | 2020 |
| Funding Finish | 2020 |
| GNo | G2000802 |
| Type Of Funding | C3120 - Aust Philanthropy |
| Category | 3120 |
| UON | Y |
Development of Nanoliposome Targeting Technology$228,000
Funding body: BORNE Foundation
| Funding body | BORNE Foundation |
|---|---|
| Project Team | Roger Smith, Jonathan Paul |
| Scheme | Project Grant |
| Role | Investigator |
| Funding Start | 2020 |
| Funding Finish | 2021 |
| GNo | |
| Type Of Funding | C3220 - International Philanthropy |
| Category | 3220 |
| UON | N |
Assessment of Myometrial Transcriptome Changes Associated with Preterm Birth$12,162
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Project Team | Jonathan Paul, Felicity Park, Craig Pennell, Bronwyn Andrew, Jason Phung |
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2020 |
| Funding Finish | 2020 |
| GNo | |
| Type Of Funding | External |
| Category | EXTE |
| UON | N |
20195 grants / $573,149
Uterine-Targeted Delivery of Dual Action Therapy for Preventing Preterm Birth$472,894
Funding body: NHMRC (National Health & Medical Research Council)
| Funding body | NHMRC (National Health & Medical Research Council) |
|---|---|
| Project Team | Doctor Jonathan Paul, Conjoint Professor Tamas Zakar, Dr Waleed Hussein |
| Scheme | Project Grant |
| Role | Lead |
| Funding Start | 2019 |
| Funding Finish | 2021 |
| GNo | G1800369 |
| Type Of Funding | Aust Competitive - Commonwealth |
| Category | 1CS |
| UON | Y |
The Applied Biosystems QuantStudio 6 Flex Real-Time PCR System$53,672
Funding body: NHMRC (National Health & Medical Research Council)
| Funding body | NHMRC (National Health & Medical Research Council) |
|---|---|
| Project Team | Associate Professor Kirsty Pringle, Professor Simon Keely, Doctor Hannah Palliser, Doctor Jonathan Paul, Doctor Marina Ilicic, Doctor Lucy Murtha |
| Scheme | Equipment Grant |
| Role | Investigator |
| Funding Start | 2019 |
| Funding Finish | 2019 |
| GNo | G1900306 |
| Type Of Funding | Scheme excluded from IGS |
| Category | EXCL |
| UON | Y |
Olympus BX53-P Polarising Microscope$16,951
Funding body: Universityof Newcastle Faulty of Health and Medicine
| Funding body | Universityof Newcastle Faulty of Health and Medicine |
|---|---|
| Project Team | Lucy Murtha, Michael Schuliga, Marina Ilicic, Jonathan Paul |
| Scheme | Equipment Grant |
| Role | Investigator |
| Funding Start | 2019 |
| Funding Finish | 2021 |
| GNo | |
| Type Of Funding | Internal |
| Category | INTE |
| UON | N |
Nikon DS-Qi2 Monochrome Camera Microscope Upgrade Package $15,675
Funding body: Faculty of Health and Medicine, The University of Newcastle
| Funding body | Faculty of Health and Medicine, The University of Newcastle |
|---|---|
| Project Team | Jonathan Paul, Trent Butler, Marina Ilicic, Jorge Tolosa, Kaushik Maiti, Kirsty Pringle, Julia Shaw, Hannah Palliser, Rohan Walker, Kirsten Coupland, Lucy Murtha, Mark Bigland, Andrew Boyle |
| Scheme | Equipment grant |
| Role | Lead |
| Funding Start | 2019 |
| Funding Finish | 2020 |
| GNo | |
| Type Of Funding | Internal |
| Category | INTE |
| UON | N |
IncuSafe MCO-5M Automatic Air Jacket Multigas Incubator$13,957
Funding body: Faculty of Health and Medicine, The University of Newcastle
| Funding body | Faculty of Health and Medicine, The University of Newcastle |
|---|---|
| Project Team | Jacinta Martin, Sarah Delforce, Kirsty Pringle, Saije Morosin, Sonia Tamanna, Alyssa Lochrin, Celine Lees, Jason Phung, Trent Butler Jonathan Paul, Bridie Goggins, Rebecca Hood, Marina Ilicic |
| Scheme | Equipment grant |
| Role | Investigator |
| Funding Start | 2019 |
| Funding Finish | 2020 |
| GNo | |
| Type Of Funding | Internal |
| Category | INTE |
| UON | N |
20182 grants / $21,267
Preventing Placental Aging and Stillbirth in a Pre-Clinical Model$17,307
Funding body: John Hunter Charitable Trust
| Funding body | John Hunter Charitable Trust |
|---|---|
| Project Team | Jonathan Paul, Bronwyn Andrew |
| Scheme | Charitable trust grant |
| Role | Lead |
| Funding Start | 2018 |
| Funding Finish | 2018 |
| GNo | |
| Type Of Funding | External |
| Category | EXTE |
| UON | N |
HMRI Imaging Centre Pilot Grant round: A Targeted Drug Delivery System for the Uterus - MRI Characterisation of Nanoliposome Biodistribution$3,960
Funding body: Newcastle Innovation
| Funding body | Newcastle Innovation |
|---|---|
| Project Team | Jonathan Paul, Susan Hua, Roger Smith |
| Scheme | Chancellor’s Award for Research Innovation |
| Role | Lead |
| Funding Start | 2018 |
| Funding Finish | 2018 |
| GNo | |
| Type Of Funding | Internal |
| Category | INTE |
| UON | N |
20174 grants / $404,380
Establishment of a Targeted Nanoparticle Development Facility at the Hunter Medical Research Institute$328,280
Funding body: Hunter Medical Research Institute
| Funding body | Hunter Medical Research Institute |
|---|---|
| Project Team | Laureate Professor Roger Smith, Doctor Jonathan Paul |
| Scheme | Project Grant |
| Role | Investigator |
| Funding Start | 2017 |
| Funding Finish | 2019 |
| GNo | G1701486 |
| Type Of Funding | C3120 - Aust Philanthropy |
| Category | 3120 |
| UON | Y |
UON 2017 Researcher Equipment Grant $46,100
Funding body: University of Newcastle
| Funding body | University of Newcastle |
|---|---|
| Project Team | Doctor Jonathan Paul |
| Scheme | Researcher Equipment Grants |
| Role | Lead |
| Funding Start | 2017 |
| Funding Finish | 2017 |
| GNo | G1701158 |
| Type Of Funding | Internal |
| Category | INTE |
| UON | Y |
A Targeted Drug Delivery System for the Uterus: Characterisation for Clinical Translation$20,000
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Project Team | Dr. Jonathan W. Paul, Dr. Susan Hua, Dr. Bronwyn Andrew |
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2017 |
| Funding Finish | 2017 |
| GNo | |
| Type Of Funding | External |
| Category | EXTE |
| UON | N |
Understanding the myometrial transition at term and preterm labour to guide tocolysis$10,000
Funding body: Royal Australian and New Zealand College of Obstetricians and Gynaecologists
| Funding body | Royal Australian and New Zealand College of Obstetricians and Gynaecologists |
|---|---|
| Project Team | Dr Jason Phung, Laureate Professor Roger Smith, Doctor Eng-Cheng Chan, Doctor Jonathan Paul, Conjoint Professor Tamas Zakar |
| Scheme | NSW Regional Committee Training Research Grant |
| Role | Investigator |
| Funding Start | 2017 |
| Funding Finish | 2017 |
| GNo | G1701454 |
| Type Of Funding | C3120 - Aust Philanthropy |
| Category | 3120 |
| UON | Y |
20161 grants / $21,745
Developing a Post-term Pregnancy Model to Study Placental Aging and Stillbirth$21,745
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Project Team | Doctor Jonathan Paul, Dr Bronwyn Andrew |
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2016 |
| Funding Finish | 2016 |
| GNo | G1600377 |
| Type Of Funding | Other Public Sector - State |
| Category | 2OPS |
| UON | Y |
20154 grants / $140,847
A safer way of treating premature labour and post-partum hemorrhage$65,625
Funding body: Seattle Children's Hospital Research Foundation
| Funding body | Seattle Children's Hospital Research Foundation |
|---|---|
| Project Team | Laureate Professor Roger Smith, Associate Professor Susan Hua, Doctor Jonathan Paul |
| Scheme | Research Grant |
| Role | Investigator |
| Funding Start | 2015 |
| Funding Finish | 2015 |
| GNo | G1501339 |
| Type Of Funding | Grant - Aust Non Government |
| Category | 3AFG |
| UON | Y |
Achieving Targeted Delivery of Drugs to Uterine Muscle in Women for the Prevention of Preterm Labour$48,000
Funding body: Hunter Medical Research Institute
| Funding body | Hunter Medical Research Institute |
|---|---|
| Project Team | Doctor Jonathan Paul, Associate Professor Susan Hua, Laureate Professor Roger Smith |
| Scheme | Project Grant |
| Role | Lead |
| Funding Start | 2015 |
| Funding Finish | 2016 |
| GNo | G1401504 |
| Type Of Funding | Grant - Aust Non Government |
| Category | 3AFG |
| UON | Y |
Developing a System for Targeting Drugs to Ovarian Cancer$25,222
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Project Team | Doctor Jonathan Paul, Doctor Geoffrey Otton, Doctor John Bailey |
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2015 |
| Funding Finish | 2015 |
| GNo | G1501110 |
| Type Of Funding | Other Public Sector - State |
| Category | 2OPS |
| UON | Y |
Society of Reproductive Investigation (SRI) 62nd Annual Scientific Meeting, San Francisco USA, 25-28 March 2015$2,000
Funding body: University of Newcastle - Faculty of Health and Medicine
| Funding body | University of Newcastle - Faculty of Health and Medicine |
|---|---|
| Project Team | Doctor Jonathan Paul |
| Scheme | Travel Grant |
| Role | Lead |
| Funding Start | 2015 |
| Funding Finish | 2016 |
| GNo | G1500525 |
| Type Of Funding | Internal |
| Category | INTE |
| UON | Y |
20121 grants / $34,454
Targeting the ether-a-go-go potassium channel as a treatment for post-partum heamorrhage$34,454
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Project Team | Dr Andrew Carlin, Doctor Jonathan Paul |
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2012 |
| Funding Finish | 2012 |
| GNo | G1200956 |
| Type Of Funding | Other Public Sector - State |
| Category | 2OPS |
| UON | Y |
20111 grants / $25,000
Role of the potassium channel hERG in regulating the onset of labor in humans$25,000
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2011 |
| Funding Finish | 2011 |
| GNo | |
| Type Of Funding | Other Public Sector - State |
| Category | 2OPS |
| UON | N |
20101 grants / $23,025
Identification of protein modifications associated with myometrial activation during the onset of labour$23,025
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2010 |
| Funding Finish | 2010 |
| GNo | |
| Type Of Funding | Other Public Sector - State |
| Category | 2OPS |
| UON | N |
20091 grants / $15,208
Apoptosis in pregnant human myometrium and its role in labour$15,208
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Project Team | Doctor Kaushik Maiti, Doctor Jonathan Paul, Doctor Pravin Nahar |
| Scheme | Research Grant |
| Role | Investigator |
| Funding Start | 2009 |
| Funding Finish | 2009 |
| GNo | G0189933 |
| Type Of Funding | Other Public Sector - State |
| Category | 2OPS |
| UON | Y |
20081 grants / $9,600
LED fluorescence illuminators and filter set (525nm + 575DF20) for LAS3000 image analysis system$9,600
Funding body: NHMRC (National Health & Medical Research Council)
| Funding body | NHMRC (National Health & Medical Research Council) |
|---|---|
| Project Team | Laureate Professor Roger Smith, Professor Ian Symonds, Conjoint Associate Professor Andrew Bisits, Conjoint Professor Tamas Zakar, Doctor John Fitter, Doctor Eng-Cheng Chan, Conjoint Associate Professor Rick Nicholson, Doctor Giavanna Angeli, Doctor Kaushik Maiti, Doctor Jonathan Paul, Professor Jon Hirst, Doctor Hannah Palliser, Professor Eugenie Lumbers |
| Scheme | Equipment Grant |
| Role | Investigator |
| Funding Start | 2008 |
| Funding Finish | 2008 |
| GNo | G0188543 |
| Type Of Funding | Other Public Sector - Commonwealth |
| Category | 2OPC |
| UON | Y |
Research Supervision
Number of supervisions
Current Supervision
| Commenced | Level of Study | Research Title | Program | Supervisor Type |
|---|---|---|---|---|
| 2018 | PhD | Next Generation Targeted Drug Delivery Strategies for Modulating Uterine Contractility During Pregnancy | PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
| 2017 | PhD | Pathways to Uterine Activation at Labour | PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
| 2014 | PhD | A Consilience Model of Group Dynamics | PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
Past Supervision
| Year | Level of Study | Research Title | Program | Supervisor Type |
|---|---|---|---|---|
| 2020 | PhD | The Precursor for Nerve Growth Factor and Innervation in Thyroid Cancer | PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
| 2018 | PhD | Epigenetic Regulation of Progesterone Receptor Isoforms in Human Parturition | PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle | Principal Supervisor |
| 2018 | PhD | Exploring Novel Application of Tissue Engineering Strategies to Human Myometrium | PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
| 2017 | Honours | Triggers of Amniote Labour | Biological Sciences, The University of Sydney | Co-Supervisor |
| 2017 | PhD | Elucidating the Role of Myosin Phosphatase in the Contractility of Myometrial Smooth Muscle | PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
Research Opportunities
Application of 3D tissue culture and bioengineering to the human uterus
The Mothers and Babies Research Centre are seeking candidates interested in undertaking a PhD on the novel application of 3D tissue culture to reproductive medicine. The project will build upon work by a current student, and seeks to apply 3D culture and tissue engineering techniques to improve in vitro studies into human uterine smooth muscle.
PHD
Faculty of Health and Medicine
1/7/2018 - 30/6/2021
http://link.springer.com/article/10.1007%2Fs10439-016-1749-5
Contact
Doctor Jonathan Paul
University of Newcastle
School of Medicine and Public Health
jonathan.paul@newcastle.edu.au
News
Nanotech revolution for pregnancy drugs
September 2, 2016
Dr Jonathan Paul
Position
Lecturer
Mothers and Babies Research Center
School of Medicine and Public Health
Faculty of Health and Medicine
Focus area
Reproductive Medicine
Contact Details
| jonathan.paul@newcastle.edu.au | |
| Phone | (02) 4042 0348 |
| Fax | (02) 4042 0045 |
Office
| Room | Level 3, East |
|---|---|
| Building | HMRI, John Hunter Hospital Campus |
| Location | Callaghan University Drive Callaghan, NSW 2308 Australia |
NEWS • Sep 02.2016
Nanotech revolution for pregnancy drugs
Dr Jonathan Paul, Laureate Professor Roger Smith AM and Dr Susan Hua have successfully targeted a hormone sensor found in the uterine muscle.
Connect with me
Featured Publication
The uterus is like a soccer crowd
Professor Roger Smith and team have found a parallel between the labouring uterus and the behaviour of...