
Dr Giavanna Angeli
HMRI Research Officer
School of Medicine and Public Health
- Email:giavanna.angeli@newcastle.edu.au
- Phone:40420350
Career Summary
Biography
Research Expertise
During my PhD studies, completed jointly in the Mothers and Babies Research Centre and the Cell Signalling Unit, at the Children’s Medical Research I developed a strong interest in intracellular signalling mechanisms, with a particular emphasis on protein kinases and protein phosphorylation. My PhD thesis explored signalling through cAMP-dependent protein kinase (PKA) in the pituitary. During this time I developed a particular interest in the actions of corticotrophin releasing hormone. Following my PhD I gained some experience in the field of vascular biology where I developed an interest in apoptosis in particular, the role of apoptosis in tissue remodelling following vascular grafting. Since returning to the Mothers and Babies Research Centre at the University of Newcastle, I have developed an interest in the syncytialisation of cytotrophoblast cells in the placenta. Fusion of cytotrophoblast cells to form the syncytiotrophoblast layer is a fundamental process in the formation and maintenance of the placenta. The dramatic changes in expression of genes that occurs as cells alter their phenotype from cytotrophoblast to syncytiotrophoblast make the placental trophoblast an ideal model in which to explore transcriptional organisation in the nucleus, in particular, the formation and function of transcription factories. I am also the Ethics Officer for the Mothers and Babies Research Centre and have gained extensive experience in the co-ordination of grant submissions.
During my PhD studies, completed jointly in the Mothers and Babies Research Centre and the Cell Signalling Unit, at the Children’s Medical Research I developed a strong interest in intracellular signalling mechanisms, with a particular emphasis on protein kinases and protein phosphorylation. My PhD thesis explored signalling through cAMP-dependent protein kinase (PKA) in the pituitary. During this time I developed a particular interest in the actions of corticotrophin releasing hormone. Following my PhD I gained some experience in the field of vascular biology where I developed an interest in apoptosis in particular, the role of apoptosis in tissue remodelling following vascular grafting. Since returning to the Mothers and Babies Research Centre at the University of Newcastle, I have developed an interest in the syncytialisation of cytotrophoblast cells in the placenta. Fusion of cytotrophoblast cells to form the syncytiotrophoblast layer is a fundamental process in the formation and maintenance of the placenta. The dramatic changes in expression of genes that occurs as cells alter their phenotype from cytotrophoblast to syncytiotrophoblast make the placental trophoblast an ideal model in which to explore transcriptional organisation in the nucleus, in particular, the formation and function of transcription factories. I am also the Ethics Officer for the Mothers and Babies Research Centre and have gained extensive experience in the co-ordination of grant submissions.
Qualifications
- PhD, University of Newcastle
- Bachelor of Science, University of Newcastle
- Bachelor of Science (Honours), University of Newcastle
Keywords
- Corticotropin releasing hormone
- FISH
- Intracellular signalling
- Placenta
- Placental cell culture
- Syncytiotrophoblast
- Transcription
Fields of Research
Code | Description | Percentage |
---|---|---|
119999 | Medical and Health Sciences not elsewhere classified | 100 |
Professional Experience
UON Appointment
Title | Organisation / Department |
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HMRI Research Officer | University of Newcastle School of Medicine and Public Health Australia |
HMRI Research Officer | Priority Research Centre (PRC) for Healthy Lungs | The University of Newcastle School of Medicine and Public Health Australia |
HMRI Research Officer | University of Newcastle School of Medicine and Public Health Australia |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (5 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2018 |
Sharma BB, Loxton DJ, Murray H, Angeli GL, Oldmeadow C, Chiu S, Smith R, 'A first step to improving maternal mortality in a low-literacy setting; the successful use of singing to improve knowledge regarding antenatal care.', Am J Obstet Gynecol, 219 615.e1-615.e11 (2018)
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2013 |
Chen Y, Allars M, Pan X, Maiti K, Angeli G, Smith R, Nicholson RC, 'Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)', REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 11 (2013) [C1]
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2011 |
Chen Y, Allars MJ, Maiti K, Angeli GL, Abou-Seif C, Smith R, Nicholson RC, 'Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis', International Journal of Biochemistry & Cell Biology, 43 821-828 (2011) [C1]
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Show 2 more journal articles |
Grants and Funding
Summary
Number of grants | 2 |
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Total funding | $33,409 |
Click on a grant title below to expand the full details for that specific grant.
20131 grants / $23,809
Testing parallels between placental and cancer cell proliferation and fusion: the role of transcription factories$23,809
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
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Project Team | Doctor Giavanna Angeli, Doctor Jorge Tolosa Gonzalez, Doctor Brett Locker, Doctor Jennette Sakoff |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1301207 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
20081 grants / $9,600
LED fluorescence illuminators and filter set (525nm + 575DF20) for LAS3000 image analysis system$9,600
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
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Project Team | Laureate Professor Roger Smith, Professor Ian Symonds, Conjoint Associate Professor Andrew Bisits, Conjoint Professor Tamas Zakar, Doctor John Fitter, Doctor Eng-Cheng Chan, Conjoint Associate Professor Rick Nicholson, Doctor Giavanna Angeli, Doctor Kaushik Maiti, Doctor Jonathan Paul, Professor Jon Hirst, Doctor Hannah Palliser, Professor Eugenie Lumbers |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0188543 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Dr Giavanna Angeli
Position
HMRI Research Officer
Mothers and Babies research Centre
School of Medicine and Public Health
Faculty of Health and Medicine
Contact Details
giavanna.angeli@newcastle.edu.au | |
Phone | 40420350 |
Fax | (02) 4042 0350 |
Office
Room | Level 3 East |
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Building | HMRI |
Location | HMRI , |