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Laureate Professor Roger Smith

Laureate Professor

School of Medicine and Public Health

A snapshot of success

A self-described 'specialised zoologist,' Laureate Professor Roger Smith is keen on understanding the idiosyncrasies, interactions and inner workings of multiple animal species but especially human.

Roger Smith

Laureate Professor Roger Smith is a man of many talents and interests. As the Co-Director of the University of Newcastle's Priority Research Centre for Reproductive Science, and the Director of the University's Mothers and Babies Research Centre and the Department of Endocrinology at John Hunter Hospital, he's also a man with many responsibilities. Not limiting himself to a singular field, the passionate academic freely studies "anything and everything" that sparks his intrigue.

"I don't' have a single focus," Roger elaborates.

"To give you an idea, I have about 25 different projects going at the moment."

"These range from explorations of potential new treatments for women in premature labour and women with postpartum haemorrhage, to the use of nanoparticles to treat thyroid and ovarian cancers."

"I'm very lucky to be able to do what I do."

A head start

Roger recalls having this affinity for the natural world from a young age. Working on the proviso that the "proof is in the picture," the esteemed educator tells of a photograph of his toddler-self feeding elephants, and its importance in kick starting his research career.

"I was thinking about how the planet works very early on in my life," he reflects.

"To me, all animals were, and continue to be, incredibly fascinating."

"Humans, however, I find most remarkable."

Seeking to satisfy this time-honoured thirst for knowledge about his own species, Roger studied medicine at the University of Sydney. Graduating in 1973, he spent the next two years at Royal North Shore Hospital followed by time in Western Australia and New Zealand, before undertaking a PhD at the University of London.

"I saw my training to become a doctor as training to become a specialised zoologist," he explains.

"My interest in people is not just in terms of their diseases, but also about how they interact with each other."

"We are the most highly social animal there is."

"This is the way I see myself and what I can contribute to our society."

After completing his doctorate in 1981, Roger returned to Australia and joined the University of Newcastle.

Well-known and well-travelled

Most recently, and perhaps most interestingly, Roger has been undertaking a research assignment on lemurs in Madagascar.

"They are surprising and extremely complex primates," he describes.

"The females are dominant over the males and their clitorises are bigger than penises, due to the different steroids produced during pregnancy."

"Oestrogen and progesterone normally regulate the onset of labour but they do all of these crazy things in lemurs so we don't yet know why they give birth when they do."

"People from the island's west coast have collected samples of poo from pregnant female lemurs and they've been transported here for analysis and comparison with samples obtained from Taronga Western Plains Zoo in Dubbo."

Spanning a generous handful of time zones, Roger's current work also sees him conducting work in Nepal. The clinical endocrinologist is on the hunt for ways to improve maternal mortality in the developing country, ambitiously and admirably looking to reduce its "exceedingly high" death rates during pregnancy.

"Women are of low standing in this culture," he points out.

Collaborating with a Nepalese postgraduate student, Roger is hoping to change this situation with a simple but powerful song.

"Music is a big part of day-to-day community life for these people," he illuminates.

"So we're going to run a competition in schools for a lyrical number that involves some key messages about respecting women."

"It will be judged by teachers – who are all male."

"Once the final song is chosen, it will be taught to travelling minstrels who will then sing it at every house in the intervention area."

"We will assess the impact of the song on attitudes to pregnant women and the care they need."

In our own backyard

Back home, Roger is endeavouring to 'close the gap' where Aboriginal health is concerned. He has set up programs in both Tamworth and Walgett, renting and renovating buildings for art and ante-natal research purposes.

"Indigenous women have double the rate of premature birth and double the rate of growth retarded babies," the multitasking scholar affirms.

"But we're trying to improve those statistics."

"We've employed Aboriginal artists and elders, as well as dieticians, midwives and lactation consultants to pass on their knowledge to expectant mothers."

"Together, they all sit down and do artworks and discuss their different areas of expertise."

Learning just as much from these women as he is by teaching them, Roger asserts the rural venture has so far been an "overwhelming success."

Thinking outside the norm

When asked where he would like to see the future of medicine and public health, Roger is quick to answer.

"They both need to change," he claims.

"These days, the troubling and most prevalent diseases are social problems – not medical ones."

"So I could tell you to eat less, start exercising and stop smoking, but then you go back to your world surrounded by family and friends who probably drink more than they should, smoke and don't exercise often."

"My five minutes with you is a waste of time."

Believing how we behave and think is "largely determined" by the people around us, Roger is calling for doctors to influence the social networks of individuals.

"I no longer meet with patients one-on-one," he reveals.

"If someone has obesity or smokes, for example, I want to meet their partner and friends and relatives."

"It's about group effort."

"After all, you can't refuse to help someone you love and care about."

More about Roger's Career

Related links

A snapshot of success

A self-described ‘specialised zoologist,’ Professor Roger Smith is keen on understanding the idiosyncrasies, interactions and inner workings of multiple animal

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Career Summary

Biography

I am an internationally recognised leader in the pathophysiology of human pregnancy. I have been awarded medals and published in Nature, Nature Medicine and the New England Journal of Medicine and Scientific American; Science has reviewed my work. I have been a visiting Professor at Harvard, Yale and the NIH Perinatal Research Branch.

Research Expertise
Clinical and basic science expertise in the physiology of human birth and the pathophysiology of premature birth.

Teaching Expertise
Teaching endocrinology to medical students

Administrative Expertise
Previous assistant dean research, currently Director of the Department of Endocrinology John Hunter Hospital and Co-Director of the University of Newcastle Priority Research Centre in Reproductive Science and Director of the Mothers and Babies Research Centre.


Qualifications

  • PhD, University of London
  • Bachelor of Medicine & Surgery, University of Sydney

Keywords

  • endocrinology
  • premature labour
  • preterm birth

Fields of Research

Code Description Percentage
060499 Genetics not elsewhere classified 15
110399 Clinical Sciences not elsewhere classified 35
111499 Paediatrics and Reproductive Medicine not elsewhere classified 50

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Medicine and Public Health
Australia

Awards

Distinction

Year Award
2014 Fellow of the Australian Society of Reproductive Biology
Australian Society of Reproductive Biology
2012 Life Member Endocrine Society of Australia for services rendered
Endocrine Society of Australia

Recognition

Year Award
2013 Member of the Order of Australia
Council for the Order of Australia
2012 Indigenous Collaboration Staff Excellence Award
University of Newcastle
2010 Excellence in Innovation Award
Newcastle Innovation
2009 Santa Chiara Prize for Multidisciplinary Research
University of Siena
2003 Fellowship ad eundem
The Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG)
2000 Asia & Oceania Medal
Society for Endocrinology
2000 Award for Research Excellence
Hunter Medical Research Institute (HMRI)

Invitations

Participant

Year Title / Rationale
2005 1st International Summit on Preterm Birth
Organisation: Society for Gynaecological Investigation Description: Roger was invited to give a Plenary lecture "Stress and the onset of human labour" in the session called "Preterm labour - mechanisms". This was the first in a series of landmark meetings focussed on topics vital to global reproductive health. This Summit addressed the important research questions relating to the prediction and prevention of preterm birth. The goal of the Summit was to produce an expert consensus document defining the current state of knowledge and important questions to be addressed in future research. Roger was also invited to be on the Scientific Committee of the Summit. This report and supporting documents were published in the Journal of the Society of Gynecological Reproduction.
2004 2nd International workshop on Biomarkers and PTD
Organisation: World Health Organisation Description: Roger was one of two Australian participants. The goals for this workshop were to generate a forum for international projects, future collaborations scientific progress based on fruitful discussions, exchange of ideas and potentially friendship. The final product was to be scientific protocols owned by all participants. 5 protocols on genetics, preconception identification of women at risk for PTB, Pathways, Time trends and preventions and interventions were generated. The International PREterm BIrth Collaborative (PREBIC) was formed at this meeting.
2003 46th RCOG Study Group
Organisation: Royal College of Obstetrics and Gynecology Description: Invited to participate in the 46th Royal College Obstetrics & Gynecology Study Group on preterm labour convened in London 21-23 Oct 2003 A small number of selected people were chosen to meet for three days to discuss preterm labour. The college attaches great importance to the Study groups both nationally and internationally through the resulting publication. Roger's talk was titled Control of the length of gestation lessons from women". This led to the following publication. Smith R, Mesiano S, Nicholson R, Zakar T, Chan E-C, Bisits A, Clifton V, Giles W. Control of the Length of Gestation-Lessons from Women. Pre-term Birth Study Group. Eds. Bennet and Thornton. Publisher: Royal College Obstetrics Gynecology 2004.
2003 24th Winter Neuropeptide Conference, Breckenridge, Colorado 1st-4th Feb
Organisation: National Institute of Health Description: Roger was invited by Dr Cathy Spong, Head of the NIH Perinatal Study Section, to Chair the session "Neuropeptides and Development".
2002 Placenta and Brain, Birth and Behavior, Health and Disease, Washington, 10th June
Organisation: American College of Obstetricians & Gynecologists Description: Roger was invited to give the opening presentation "Regulation of Human Parturition". This symposium established collaborations which led to Roger Smith and Rick Nicholson being co-chief investigators on a major NIH program grant. The following publication resulted from this symposium:- Smith R, Mesiano S, Nicholson R, Clifton V, Zakar T, Chan E-C, Bisits A, Giles W. The Regulation of Human Parturition. In Birth Distress and Disease. Eds. Michael Power, Jay Schulkin. Publisher: Cambridge University Press, Cambridge UK pp77-90 2006

Speaker

Year Title / Rationale
2016 Placental aging and stillbirth
2015 Molecular Mechanisms of Placental Dysfunction
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

Year Citation Altmetrics Link
2001 Smith R, The Endocrinology of Parturition ¿ Basic Science and Clinical Application, Karger, London, 316 (2001) [A3]

Chapter (13 outputs)

Year Citation Altmetrics Link
2013 Smith R, Paul J, Chan C, Keelan J, 'The role of the primate placenta in term and preterm parturition', The Placenta: Development, Function and Diseases, Nova Science, Hauppaugue, NY 335-346 (2013) [B1]
Co-authors Jonathan Paul
2012 Schjenken JE, Tolosa Gonzalez JM, Paul JW, Clifton VL, Smith R, 'Mechanisms of maternal immune tolerance during pregnancy', Recent Advances in Research on the Human Placenta, InTech, Rijeka, Croatia 211-242 (2012) [B1]
Co-authors Jonathan Paul
2012 Pan X, Smith R, Zakar T, 'DNA methylation in development', Embryology - Updates and Highlights on Classic Topics, InTech, Rijeka, Croatia 143-170 (2012) [B1]
DOI 10.5772/37696
2011 Young IR, Renfree MB, Mesiano S, Shaw G, Jenkin G, Smith R, 'The comparative physiology of parturition in mammals: Hormones and paturition in mammals', Hormones and Reproduction of Vertebrates Volume 5: Mammals, Elsevier, Amsterdam 95-116 (2011) [B1]
Citations Scopus - 4
2010 Smith R, Smith JI, Bisits AM, 'The Endocrine Regulation of Human Labour', Preterm Birth: Prevention and Management, Wiley-Blackwell, Hoboken 78-87 (2010) [B1]
2010 Smith R, Lau SL, 'The endocrinology of human pregnancy and parturition', Endocrinology: Adult and Pediatric, Saunders Elsevier, Philadelphia, PA 2612-2623 (2010) [B2]
2007 Smith R, 'Stress and the pathophysiology of human birth', Preterm Birth: Mechanisms, Mediators, Prediction, Prevention and Interventions, Informa Healthcare, London, United Kingdom 42-48 (2007) [B1]
2006 Murphy VE, Smith R, Giles WB, Clifton VL, 'The role of the mother, placenta, and fetus in the control of fetal growth during human pregnancy', Perinatal Programming: Early Life Determinants of Adult Health & Disease, Taylor & Francis, London 3-16 (2006) [B1]
Co-authors Vanessa Murphy, Vicki Clifton
2005 Smith R, Mesiano S, Nicholson RC, Clifton VL, Zakar T, Chan EC, et al., 'The Regulation of Human Parturition', Birth, Distress and Disease: Placental-Brain Interactions, Cambridge University Press, Cambridge 77-90 (2005) [B1]
Co-authors Vicki Clifton
2005 Smith R, Mesiano S, Nicholson R, Clifton V, Zakar T, Chan EC, et al., 'The regulation of human parturition', Birth, Distress and Disease: Placental-Brain Interactions 74-87 (2005)

Preterm birth accounts for 70% of neonatal mortality and is a common cause for intellectual handicap among survivors. Approximately 50% of cases of cerebral palsy are associated w... [more]

Preterm birth accounts for 70% of neonatal mortality and is a common cause for intellectual handicap among survivors. Approximately 50% of cases of cerebral palsy are associated with preterm birth, in turn preterm birth increases the risk of cerebral palsy by 40 times! (Goldenberg, 2002). Preterm labor thus afflicts individuals at the very beginning of their lives, depriving them of opportunities and increasing health and educational costs for families and society in general. Unfortunately the rates of preterm birth have not changed for over 30 years due to an inability to predict the event and lack of effective therapies. This clinical problem has driven research into the mechanisms that regulate the timing of human birth and the disorders which cause preterm birth. For reasons of ethics most research in the past has focused on animal work, especially in the sheep. Unfortunately studies have revealed substantial differences between parturition in humans and that in other animals. Thus animal studies provide us with clues as to how systems operate to regulate delivery in mammals but frustrate us with uncertainty as to whether particular mechanisms operate in the human. Experimental in vivo studies provide the strongest evidence for cause and effect, yet the closer we come to the human state in our near relatives the apes, the larger the ethical constraints on experimental studies become.

DOI 10.1017/CBO9780511545658.004
Citations Scopus - 6
2004 Smith R, Mesiano S, Nicholson RC, Zakar T, Chan EC, Bisits AM, et al., 'Control of the length of gestation: lessons from women', Preterm Birth, RCOG Press, London 13-27 (2004) [B1]
Co-authors Vicki Clifton
2001 Cole S, Smith R, Bisits AM, 'Pharmacotherapy for Preterm Labour', The Endocrinology of Parturition, Karger, Switzerland 279-307 (2001) [B1]
Citations Scopus - 3Web of Science - 2
2000 Smith R, Changs E-C, Mesiano S, Nicholson R, Cheng Y-H, Bowman M, et al., 'Regulation of parturition: The role of CRH', Hormones and Women's Health The Reproductive Years, Harwood Academic Publishers, Amsterdam, The Netherlands 215-219 (2000) [B1]
Co-authors Maria Bowman, Gemma Madsen, Vicki Clifton, John Fitter
Show 10 more chapters

Journal article (244 outputs)

Year Citation Altmetrics Link
2017 Kandasamy Y, Hartley L, Rudd D, Smith R, 'The association between systemic vascular endothelial growth factor and retinopathy of prematurity in premature infants: a systematic review.', Br J Ophthalmol, 101 21-24 (2017)
DOI 10.1136/bjophthalmol-2016-308828
2016 Mah BL, Van Ijzendoorn MH, Out D, Smith R, Bakermans-Kranenburg MJ, 'The Effects of Intranasal Oxytocin Administration on Sensitive Caregiving in Mothers with Postnatal Depression.', Child Psychiatry Hum Dev, (2016)
DOI 10.1007/s10578-016-0642-7
Citations Scopus - 1
2016 Albrecht C, Caniggia I, Clifton V, Göhner C, Harris L, Hemmings D, et al., 'IFPA meeting 2015 workshop report III: nanomedicine applications and exosome biology, xenobiotics and endocrine disruptors and pregnancy, and lipid.', Placenta, 48 Suppl 1 S12-S16 (2016)
DOI 10.1016/j.placenta.2016.01.003
2016 De Sousa SMC, Maiti K, Smith R, McCormack AI, 'Corticotrophin-releasing hormone (CRH) expression in the dermoid component of ovarian teratomas', Journal of the European Academy of Dermatology and Venereology, 30 867-869 (2016)
DOI 10.1111/jdv.13035
2016 Paul JW, Hua S, Ilicic M, Tolosa JM, Butler T, Robertson S, Smith R, 'Drug delivery to the human and mouse uterus using immunoliposomes targeted to the oxytocin receptor.', Am J Obstet Gynecol, (2016)
DOI 10.1016/j.ajog.2016.08.027
Co-authors Jonathan Paul, Susan Hua
2016 Ashman AM, Collins CE, Weatherall LJ, Keogh L, Brown LJ, Rollo ME, et al., 'Dietary intakes and anthropometric measures of Indigenous Australian women and their infants in the Gomeroi gaaynggal cohort', Journal of Developmental Origins of Health and Disease, 7 481-497 (2016) [C1]
DOI 10.1017/S2040174416000325
Citations Scopus - 1Web of Science - 1
Co-authors Kym Rae, Megan Rollo, Clare Collins, Leanne Brown
2016 Ashman AM, Collins CE, Weatherall L, Brown LJ, Rollo ME, Clausen D, et al., 'A cohort of Indigenous Australian women and their children through pregnancy and beyond: The Gomeroi gaaynggal study', Journal of Developmental Origins of Health and Disease, 7 357-368 (2016) [C1]

© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016.Indigenous Australians have high rates of chronic diseases, the ca... [more]

© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2016.Indigenous Australians have high rates of chronic diseases, the causes of which are complex and include social and environmental determinants. Early experiences in utero may also predispose to later-life disease development. The Gomeroi gaaynggal study was established to explore intrauterine origins of renal disease, diabetes and growth in order to inform the development of health programmes for Indigenous Australian women and children. Pregnant women are recruited from antenatal clinics in Tamworth, Newcastle and Walgett, New South Wales, Australia, by Indigenous research assistants. Measures are collected at three time points in pregnancy and from women and their children at up to eight time points in the child's first 5 years. Measures of fetal renal development and function include ultrasound and biochemical biomarkers. Dietary intake, infant feeding and anthropometric measurements are collected. Standardized procedures and validated tools are used where available. Since 2010 the study has recruited over 230 women, and retained 66 postpartum. Recruitment is ongoing, and Gomeroi gaaynggal is currently the largest Indigenous pregnancy-through-early-childhood cohort internationally. Baseline median gestational age was 39.1 weeks (31.5-43.2, n=110), median birth weight was 3180 g (910-5430 g, n=110). Over one third (39.3%) of infants were admitted to special care or neonatal nursery. Nearly half of mothers (47.5%) reported tobacco smoking during pregnancy. Results of the study will contribute to knowledge about origins of chronic disease in Indigenous Australians and nutrition and growth of women and their offspring during pregnancy and postpartum. Study strengths include employment and capacity-building of Indigenous staff and the complementary ArtsHealth programme.

DOI 10.1017/S204017441600009X
Citations Web of Science - 1
Co-authors Leanne Brown, Caroline Blackwell, Kym Rae, John Attia, Megan Rollo, Clare Collins, Kirsty Pringle
2016 Stirrat LI, O'Reilly JR, Barr SM, Andrew R, Riley SC, Howie AF, et al., 'Decreased maternal hypothalamic-pituitary-adrenal axis activity in very severely obese pregnancy: Associations with birthweight and gestation at delivery', Psychoneuroendocrinology, 63 135-143 (2016) [C1]

© 2015 Elsevier Ltd.Background: The maternal hypothalamic-pituitary-adrenal-axis (HPAA) undergoes dramatic activation during pregnancy. Increased cortisol and corticotrophin-rele... [more]

© 2015 Elsevier Ltd.Background: The maternal hypothalamic-pituitary-adrenal-axis (HPAA) undergoes dramatic activation during pregnancy. Increased cortisol and corticotrophin-releasing-hormone (CRH) associate with low birthweight and preterm labor. In non-pregnant obesity, the HPAA is activated but circulating cortisol levels are normal or lower than in lean women. We hypothesized that maternal cortisol levels would be lower in obese pregnancy, and would associate with increased fetal size and length of gestation. Method: Fasting serum cortisol was measured at 16, 28 and 36 weeks gestation and at 3-6 months postpartum in 276 severely obese and 135 lean women. In a subset of obese (n = 20) and lean (n = 20) we measured CRH, hormones that regulate bioavailable cortisol (corticosteroid-binding-globulin, estradiol, estriol, and progesterone). Urinary glucocorticoid metabolites were measured in pregnant (obese n = 6, lean n = 5) and non-pregnant (obese n = 7, lean n = 7) subjects. Results: Maternal cortisol and HPAA hormones were lower in obese pregnancy. Total urinary glucocorticoid metabolites increased significantly in lean pregnancy, but not in obese. Lower maternal cortisol in obese tended to be associated with increased birthweight (r = -0.13, p = 0.066). In obese, CRH at 28 weeks correlated inversely with gestational length (r = -0.49, p = 0.04), and independently predicted gestational length after adjustment for confounding factors (mean decrease in CRH of -0.25 pmol/L (95% CI -0.45 to -0.043 pmol/L) per/day increase in gestation). Conclusion: In obese pregnancy, lower maternal cortisol without an increase in urinary glucocorticoid clearance may indicate a lesser activation of the HPAA than in lean pregnancy. This may offer a novel mechanism underlying increased birthweight and longer gestation in obese pregnancy.

DOI 10.1016/j.psyneuen.2015.09.019
Citations Scopus - 4Web of Science - 2
Co-authors Maria Bowman
2016 Heidari Kani M, Chan EC, Young RC, Butler T, Smith R, Paul JW, '3D Cell Culturing and Possibilities for Myometrial Tissue Engineering', Annals of Biomedical Engineering, 1-12 (2016)

© 2016 Biomedical Engineering SocietyResearch insights into uterine function and the mechanisms of labour have been hindered by the lack of suitable animal and cellular models. T... [more]

© 2016 Biomedical Engineering SocietyResearch insights into uterine function and the mechanisms of labour have been hindered by the lack of suitable animal and cellular models. The use of traditional culturing methods limits the exploration of complex uterine functions, such as cell interactions, connectivity and contractile behaviour, as it fails to mimic the three-dimensional (3D) nature of uterine cell interactions in vivo. Animal models are an option, however, use of these models is constrained by ethical considerations as well as translational limitations to humans. Evidence indicates that these limitations can be overcome by using 3D culture systems, or 3D Bioprinters, to model the in vivo cytological architecture of the tissue in an in vitro environment. 3D cultured or 3D printed cells can be used to form an artificial tissue. This artificial tissue can not only be used as an appropriate model in which to study cellular function and organisation, but could also be used for regenerative medicine purposes including organ or tissue transplantation, organ donation and obstetric care. The current review describes recent developments in cell culture that can facilitate the development of myometrial 3D structures and tissue engineering applications.

DOI 10.1007/s10439-016-1749-5
Co-authors Jonathan Paul
2016 Rowe CW, Murray K, Woods A, Gupta S, Smith R, Wynne K, 'Management of metastatic thyroid cancer in pregnancy: risk and uncertainty.', Endocrinol Diabetes Metab Case Rep, 2016 (2016)
DOI 10.1530/EDM-16-0071
2016 Chai LK, Macdonald-Wicks L, Hure AJ, Burrows TL, Blumfield ML, Smith R, Collins CE, 'Disparities exist between the Australian Guide to Healthy Eating and the dietary intakes of young children aged two to three years', Nutrition and Dietetics, 73 312-320 (2016) [C1]

© 2015 Dietitians Association of AustraliaAim: To compare dietary intakes of young children to the Australian Guide to Healthy Eating (AGHE) and Nutrient Reference Values (NRVs).... [more]

© 2015 Dietitians Association of AustraliaAim: To compare dietary intakes of young children to the Australian Guide to Healthy Eating (AGHE) and Nutrient Reference Values (NRVs). Methods: Dietary intakes of 54 children (50% girls) aged two to three years (mean 2.7 years) from the Women and Their Children's Health (WATCH) study were reported by mothers using a validated 120-item food frequency questionnaire. Daily consumption of AGHE food group servings, macronutrients, and micronutrients were compared to the AGHE and NRVs using t-test with significance set at P < 0.05. Results: No child achieved all AGHE targets, with the majority consuming less breads/cereals (1.9 vs 4.0 servings/day), vegetables (1.3 vs 2.5), and meat/alternatives (0.7 vs 1.0), all P < 0.0001. Adequate servings were observed for dairy (2.2 vs 1.5) and fruit (1.3 vs 1.0). Macronutrients were within recommended ranges, although 96% exceeded saturated fatty acid recommendations. Children who met selected NRVs consumed more fruit (1.4 vs 1.0; P < 0.0086), dairy (2.2 vs 1.5; P < 0.0001) and discretionary foods (2.6 vs =1.0; P < 0.0001) but less breads/cereals (2.0 vs 4.0; P < 0.0001) and vegetables (1.3 vs 2.5; P < 0.0001) servings, compared to the AGHE recommended servings. Conclusions: Child dietary intakes did not align with AGHE, while adequate nutrient profiles were achieved by various dietary patterns. Future studies involving data from larger, representative samples of children are warranted.

DOI 10.1111/1747-0080.12203
Co-authors Tracy Burrows, Clare Collins, Li K Chai, Lesley Wicks, Alexis Hure
2016 Heslop B, Bailey K, Paul JW, Drew AJ, Smith R, 'Collaboration Guidelines to Transform Culture', Interdisciplinary Journal of Partnership Studies, 3 1-25 (2016)
Co-authors Jonathan Paul, Antony Drew
2015 Smith R, 'Reapplying the uterine brake in preterm labor', Science Translational Medicine, 7 (2015) [C3]
DOI 10.1126/scitranslmed.aad9788
2015 Pan X, Bowman M, Scott RJ, Fitter J, Nicholson RC, Smith R, Zakar T, 'Methylation of the Corticotropin Releasing Hormone Gene Promoter in BeWo Cells: Relationship to Gene Activity', International Journal of Endocrinology, 2015 (2015) [C1]

© 2015 Xin Pan et al.Corticotropin releasing hormone (CRH) production by the human placenta increases exponentially as pregnancy advances, and the rate of increase predicts gesta... [more]

© 2015 Xin Pan et al.Corticotropin releasing hormone (CRH) production by the human placenta increases exponentially as pregnancy advances, and the rate of increase predicts gestational length. CRH gene expression is regulated by cAMP in trophoblasts through a cyclic AMP-response element (CRE), which changes its transcription factor binding properties upon methylation. Here we determined whether methylation of the CRH proximal promoter controls basal and cAMP-stimulated CRH expression in BeWo cells, a well-characterized trophoblastic cell line. We treated the cells with 8-Br-cAMP and the DNA methyltransferase inhibitor 5-aza-2' deoxycytidine (5-AZA-dC) and determined the effects on CRH mRNA level and promoter methylation. Clonal bisulfite sequencing showed partial and allele independent methylation of CpGs in the CRH promoter. CRH mRNA expression and the methylation of a subset of CpGs (including CpG2 in the CRE) increased spontaneously during culture. 8-Br-cAMP stimulated CRH expression without affecting the increase in methylation. 5-AZA-dC decreased methylation and augmented 8-Br-cAMP-stimulated CRH expression, but it blocked the spontaneous increase of CRH mRNA level. We conclude that the CRH promoter is a dynamically and intermediately methylated genomic region in BeWo cells. Promoter methylation did not inhibit CRH gene expression under the conditions employed; rather it determined the contribution of alternative cAMP-independent pathways and cAMP-independent mechanisms to CRH expression control.

DOI 10.1155/2015/861302
Co-authors Rodney Scott, John Fitter, Maria Bowman
2015 Pringle KG, Weatherall L, Corbisier de Meaultsart C, Keogh L, Sands S, Blackwell C, et al., 'The Gomeroi Gaaynggal Cohort: A Preliminary Study of the Maternal Determinants of Pregnancy Outcomes in Indigenous Australian Women', Journal of Pregnancy and Child Health, 3 (2015) [C1]
DOI 10.4172/2376-127X.1000211
Co-authors Kym Rae, Kirsty Pringle, Clare Collins, Sharron Hall, Caroline Blackwell
2015 Pringle KG, Rae K, Weatherall L, Hall S, Burns C, Smith R, et al., 'Effects of maternal inflammation and exposure to cigarette smoke on birth weight and delivery of preterm babies in a cohort of Indigenous Australian women', Frontiers in Immunology, 6 (2015) [C1]

© 2015 Pringle, Rae, Weatherall, Hall, Burns, Smith, Lumbers and Blackwell.Sudden infant death syndrome (SIDS), neonatal deaths, and deaths from infection are higher among Indige... [more]

© 2015 Pringle, Rae, Weatherall, Hall, Burns, Smith, Lumbers and Blackwell.Sudden infant death syndrome (SIDS), neonatal deaths, and deaths from infection are higher among Indigenous Australians. This study aimed to determine the effects of inflammatory responses and exposure to cigarette smoke, two important factors associated with sudden death in infancy, on preterm birth, and birth weight in a cohort of Indigenous mothers. Indigenous Australian women (n = 131) were recruited as part of a longitudinal study while attending antenatal care clinics during pregnancy; blood samples were collected up to three times in pregnancy. Serum cotinine, indicating exposure to cigarette smoke, was detected in 50.4% of mothers. Compared with non-Indigenous women, the cohort had 10 times the prevalence of antibodies to Helicobacter pylori (33 vs. 3%). Levels of immunoglobulin G, antibodies to H. pylori, and C-reactive protein (CRP) were all inversely correlated with gestational age (P < 0.05). CRP levels were positively associated with maternal body mass index (BMI; ¿ = 0.449, P = 0.001). The effects of cigarette smoke (cotinine) and inflammation (CRP) were assessed in relation to risk factors for SIDS: gestational age at delivery and birth weight. Serum cotinine levels were negatively associated with birth weight (¿ = -0.37, P < 0.001), this correlation held true for both male (¿ = -0.39, P = 0.002) and female (¿ = -0.30, P = 0.017) infants. Cotinine was negatively associated with gestational age at delivery (¿ = -0.199, P = 0.023). When assessed by fetal sex, this was significant only for males (¿ = -0.327, P = 0.011). CRP was negatively associated with gestational age at delivery for female infants (¿ = -0.46, P < 0.001). In contrast, maternal BMI was significantly correlated with birth weight. These data highlight the importance of putting programs in place to reduce cigarette smoke exposure in pregnancy and to treat women with chronic infections such as H. pylori to improve pregnancy outcomes and decrease risk factors for sudden death in infancy.

DOI 10.3389/fimmu.2015.00089
Citations Scopus - 1
Co-authors Sharron Hall, Caroline Blackwell, Kirsty Pringle, Kym Rae
2015 Blumfield ML, Nowson C, Hure AJ, Smith R, Simpson SJ, Raubenheimer D, et al., 'Lower protein-to-carbohydrate ratio in maternal diet is associated with higher childhood systolic blood pressure up to age four years', Nutrients, 7 3078-3093 (2015) [C1]

© 2015 by the authors; licensee MDPI, Basel, Switzerland.The prenatal environment can influence development of offspring blood pressure (BP), which tracks into adulthood. This pr... [more]

© 2015 by the authors; licensee MDPI, Basel, Switzerland.The prenatal environment can influence development of offspring blood pressure (BP), which tracks into adulthood. This prospective longitudinal study investigated whether maternal pregnancy dietary intake is associated with the development of child BP up to age four years. Data are from 129 mother-child dyads enrolled in the Women and Their Children¿s Health study. Maternal diet was assessed using a validated 74-item food frequency questionnaire at 18 to 24 weeks and 36 to 40 weeks, with a reference period of the previous three months. Child systolic and diastolic BP were measured at 3, 6, 9, 12, 24, 36 and 48 months, using an automated BP monitor. Using mixed-model regression analyses adjusted for childhood growth indices, pregnancy intakes of percentage of energy (E%) polyunsaturated fat (ß coefficient 0.73; 95% CI 0.003, 1.45; p = 0.045), E% omega-6 fatty acids (ß coefficient 0.89; 95% CI 0.09, 1.69; p = 0.03) and protein-to-carbohydrate (P:C) ratio (ß coefficient -14.14; 95% CI -27.68, -0.60; p = 0.04) were associated with child systolic BP trajectory up to 4 years. Child systolic BP was greatest at low proportions of dietary protein (<16% of energy) and high carbohydrate (>40% of energy) intakes. There may be an ideal maternal macronutrient ratio associated with optimal infant BP. Maternal diet, which is potentially modifiable, may play an important role in influencing offspring risk of future hypertension.

DOI 10.3390/nu7053078
Citations Scopus - 3Web of Science - 2
Co-authors Alexis Hure, Lesley Wicks, Clare Collins
2015 Spencer L, Rollo M, Hauck Y, MacDonald-Wicks L, Wood L, Hutchesson M, et al., 'The effect of weight management interventions that include a diet component on weight-related outcomes in pregnant and postpartum women: a systematic review protocol.', JBI Database System Rev Implement Rep, 13 88-98 (2015)
DOI 10.11124/jbisrir-2015-1812
Co-authors Lisa Wood, Melinda Hutchesson, Megan Rollo, Lesley Wicks
2015 Martin J, MacDonald-Wicks L, Hure A, Smith R, Collins CE, Collins CE, 'Reducing postpartum weight retention and improving breastfeeding outcomes in overweight women: A pilot randomised controlled trial', Nutrients, 7 1465-1479 (2015) [C1]

© 2015 by the authors; licensee MDPI, Basel, Switzerland.Overweight and obesity is prevalent among women of reproductive age (42% BMI > 25 kg/m2) and parity is associated with ri... [more]

© 2015 by the authors; licensee MDPI, Basel, Switzerland.Overweight and obesity is prevalent among women of reproductive age (42% BMI > 25 kg/m2) and parity is associated with risk of weight gain. Weight gain greater than that recommended by the Institute of Medicine (IOM)is also associated with lower rates of breastfeeding initiation and duration in women. The aim of this pilot randomised controlled trial is to examine the feasibility of recruiting and maintaining a cohort of pregnant women with the view of reducing postpartum weight retention and improving breastfeeding outcomes. Women (BMI of 25¿35 kg/m2 (n = 36)) were recruited from the John Hunter Hospital antenatal clinic in New South Wales, Australia. Participants were stratified by BMI and randomised to one of three groups with follow-up to six months postpartum. Women received a dietary intervention with or without breastfeeding support from a lactation consultant, or were assigned to a wait-list control group where the dietary intervention was issued at three months postpartum. Feasibility and acceptability was assessed by participation rates and questionnaire. Analysis of variance and covariance was conducted to determine any differences between groups. Sixty-nine per cent of the participants were still enrolled at six months postpartum. This pilot demonstrated some difficulties in recruiting women from antenatal clinics and retaining them in the trial. Although underpowered; the results on weight; biomarkers and breastfeeding outcomes indicated improved metabolic health.

DOI 10.3390/nu7031464
Citations Scopus - 1Web of Science - 3
Co-authors Clare Collins, Alexis Hure, Lesley Wicks
2015 Burns C, Hall ST, Smith R, Blackwell C, 'Cytokine levels in late pregnancy: Are female infants better protected against inflammation?', Frontiers in Immunology, 6 (2015) [C1]

© 2015 Burns, Hall, Smith and Blackwell.Inflammatory responses have been implicated in several forms of infant deaths (sudden expected deaths and stillbirths) and the initiation ... [more]

© 2015 Burns, Hall, Smith and Blackwell.Inflammatory responses have been implicated in several forms of infant deaths (sudden expected deaths and stillbirths) and the initiation of pre-term births. In this study, we examined matched samples of term maternal blood, cord blood, and amniotic fluid obtained from 24 elective cesarean deliveries for both pro- and anti-inflammatory cytokines thought to be important in maintaining a balanced response leading to successful pregnancy outcome. These included interleukin (IL)-1ß, IL-6, IL-8, tumor necrosis factor-a (TNF-a), interferon-¿ (IFN-¿), IL-10, and IL-1 receptor antagonist (IL-1ra). Amniotic fluid levels for each of the cytokines examined were significantly higher than those for cord blood or maternal plasma. While pro-inflammatory cytokines were higher in amniotic fluid associated with male fetuses compared with females, the major significant difference was higher levels of IL-1ra in amniotic fluid associated with female fetuses. Our study supports similar findings for cytokines during mid-trimester, which noted that amniotic fluid levels were higher than those in maternal blood. Our study suggests that maternal decidua secretes additional IL-ra in the presence of a female conceptus which improves the likelihood of a good outcome compared to pregnancies with male fetuses.

DOI 10.3389/fimmu.2015.00318
Citations Scopus - 1Web of Science - 2
Co-authors Sharron Hall, Caroline Blackwell
2015 Tolosa JM, Parsons KS, Hansbro PM, Smith R, Wark PB, 'The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza', PLoS ONE, 10 (2015) [C1]

© 2015 Tolosa et al.Background Pregnancy increases susceptibility to influenza. The placenta releases an immunosuppressive endogenous retroviral protein syncytin-1.We hypothesise... [more]

© 2015 Tolosa et al.Background Pregnancy increases susceptibility to influenza. The placenta releases an immunosuppressive endogenous retroviral protein syncytin-1.We hypothesised that exposure of peripheral monocytes (PBMCs) to syncytin-1 would impair responses to H1N1pdm09 influenza. Methods and Findings Recombinant syncytin-1 was produced. PBMCs from non-pregnant women (n=10) were exposed to H1N1pdm09 in the presence and absence of syncytin-1 and compared to responses of PBMCs from pregnant women (n=12). PBMCs were characterised using flow cytometry, release of interferon (IFN)-a, IFN-¿, IFN-¿, IL-10, IL-2, IL-6 and IL-1ß were measured by cytometric bead array or ELISA. Exposure of PBMCs to H1N1pdm09 resulted in the release of IFN-a, (14,787 pg/mL, 95% CI 7311-22,264 pg/mL) IFN-¿ (1486 pg/mL, 95% CI 756-2216 pg/mL) and IFN-¿ (852 pg/mL, 95% CI 193-1511 pg/mL) after 48 hours. This was significantly impaired in pregnant women (IFN-a; p<0.0001 and IFN-¿; p<0.001). Furthermore, in the presence of syncytin-1, PBMCs demonstrated marked reductions in IFN-a and IFN-¿, while enhanced release of IL-10 as well as IL-6 and IL-1ß. Conclusions Our data indicates that a placental derived protein, syncytin-1 may be responsible for the heightened vulnerability of pregnant women to influenza.

DOI 10.1371/journal.pone.0118629
Citations Scopus - 5Web of Science - 4
Co-authors Peter Wark, Philip Hansbro
2015 Mah BL, Bakermans-Kranenburg MJ, Van Ijzendoorn MH, Smith R, 'Oxytocin promotes protective behavior in depressed mothers: A pilot study with the enthusiastic stranger paradigm', Depression and Anxiety, 32 76-81 (2015) [C1]

© 2014 Wiley Periodicals, Inc.Background Successful parenting requires maternal behaviors that promote infant survival such as protection from predators. In animal studies, oxyto... [more]

© 2014 Wiley Periodicals, Inc.Background Successful parenting requires maternal behaviors that promote infant survival such as protection from predators. In animal studies, oxytocin (OT) has been linked to maternal aggression to protect offspring. No human study has explored this topic. Mothers with a diagnosis of postnatal depression (PND) are at higher risk of neglecting their infants. We hypothesized that intranasal OT administration would increase the protective behaviors of mothers with PND, toward their infants. Methods Sixteen mothers with a diagnosis of PND participated in a double-blind, randomized-controlled, within-subject pilot study. Participants received intranasal OT during one visit and placebo spray on the alternate visit. Maternal protective behavior toward their infant was measured, in the presence of a socially intrusive stranger. Results The enthusiastic stranger paradigm stimulated participants' protective responses in the presence of an intrusive stranger. Furthermore, this protective response of mothers with a diagnosis of PND was increased in the OT condition. Conclusions The study introduces a new paradigm, the enthusiastic stranger paradigm, which may be used to examine a neglected type of parental behavior, that is, protection of offspring. The protective response of mothers with PND increased, in line with the 'tend and defend' effects of OT in animal models. In future work it should be tested whether this protection effect can also be found in nonclinical samples, or whether it is specific for clinically depressed mothers.

DOI 10.1002/da.22245
Citations Scopus - 9
2015 Smith R, Imtiaz M, Banney D, Paul JW, Young RC, 'Why the heart is like an orchestra and the uterus is like a soccer crowd', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 213 181-185 (2015) [C1]
DOI 10.1016/j.ajog.2015.06.040
Citations Scopus - 6Web of Science - 6
Co-authors Jonathan Paul
2015 Banney D, Young R, Paul JW, Imtiaz M, Smith R, 'A hypothesis for self-organization and symmetry reduction in the synchronization of organ-level contractions in the human uterus during labor', Symmetry, 7 1981-1988 (2015) [C1]

© 2015 by the authors.We present a hypothesis for a mechanism involving self-organization of small functional units that leads to organ-level synchronization of uterine contracti... [more]

© 2015 by the authors.We present a hypothesis for a mechanism involving self-organization of small functional units that leads to organ-level synchronization of uterine contractions in human labor. This view is in contrast to the long-held presumption that the synchronized behavior of the uterus is subject to well-defined internal organization (as is found in the heart) that exists prior to the onset of labor. The contractile units of the uterus are myocytes, which contract in response to both mechanical stretch and electrical stimulation. Throughout pregnancy progesterone maintains quiescence by suppression of "contraction-associated proteins" (CAPs). At the end of pregnancy a functional withdrawal of progesterone and an increasingly estrogenic environment leads to an increase in the production of CAPs. One CAP of particular importance is connexin 43, which creates gap junctions between the myocytes that cause them to become electrically coupled. The electrical connectivity between myocytes, combined with an increase in intrauterine pressure at the end of pregnancy shifts the uterus towards an increasingly unstable critical point, characterized by irregular, uncoordinated contractions. We propose that synchronous, coordinated contractions emerge from this critical point through a process of self-organization, and that the search for a uterine pacemaker has been unfruitful for the sole reason that it is non-existent.

DOI 10.3390/sym7042047
Citations Scopus - 1Web of Science - 1
Co-authors Jonathan Paul
2014 Kandasamy Y, Smith R, Lumbers ER, Rudd D, 'Nephrin - a biomarker of early glomerular injury.', Biomarker Research, 2 1-8 (2014) [C1]
2014 Parkington HC, Stevenson J, Tonta MA, Paul J, Butler T, Maiti K, et al., 'Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women', Nature Communications, 5 (2014) [C1]

Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action pot... [more]

Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (a-conducting and ßinhibitory subunits) and hERG currents exist in isolated patch-clamped human myometrial cells. We show that hERG channel activity suppresses contraction amplitude and duration before labour, thereby facilitating quiescence. During established labour, expression of ß-inhibitory protein is markedly enhanced, resulting in reduced hERG activity that is associated with an increased duration of uterine action potentials and contractions. Thus, changes in hERG channel activity contribute to electrophysiological mechanisms that produce contractions during labour. We also demonstrate that this system fails in women with elevated BMI, who have enhanced hERG activity as a result of low ß-inhibitory protein expression, which likely contributes to the weak contractions and poor labour outcomes observed in many obese women necessitating caesarean delivery. © 2014 Macmillan Publishers Limited.

DOI 10.1038/ncomms5108
Citations Scopus - 7Web of Science - 5
Co-authors Jonathan Paul
2014 Tong W-C, Tribe RM, Smith R, Taggart MJ, 'Computational Modeling Reveals Key Contributions of KCNQ and hERG Currents to the Malleability of Uterine Action Potentials Underpinning Labor', PLoS ONE, 9 e114034-e114034 (2014) [C1]
DOI 10.1371/journal.pone.0114034
Citations Scopus - 5
2014 Rae KM, Weatherall L, Blackwell CC, Pringle K, Smith R, Lumbers E, 'Long conversations: Gomeroi gaaynggal tackles renal disease in the Indigenous community', Australasian Epidemiologist, 21 44-48 (2014) [C2]
Co-authors Kym Rae, Kirsty Pringle, Caroline Blackwell
2014 Chai SY, Smith R, Fitter JT, Mitchell C, Pan X, Ilicic M, et al., 'Increased progesterone receptor a expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A', Molecular Human Reproduction, 20 442-453 (2014) [C1]

Progesterone regulates female reproductive function predominantly through two nuclear progesterone receptors (PRs), PR-A and PR-B. During human parturition myometrial PR expressio... [more]

Progesterone regulates female reproductive function predominantly through two nuclear progesterone receptors (PRs), PR-A and PR-B. During human parturition myometrial PR expression is altered to favour PR-A, which activates pro-labour genes. We have previously identified histone H3 lysine 4 trimethylation (H3K4me3) as an activator of myometrial PR-A expression at labour. To further elucidate the mechanisms regulating PR isoform expression in the human uterus at labour, we have (i) determined the methylation profile of the cytosine-guanine dinucleotides (CpG) island in the promoter region of the PR gene and (ii) identified the histone-modifying enzymes that target the H3K4me3 mark at the PR promoters in term and preterm human myometrial tissues obtained before and after labour onset. Bisulphite sequencing showed that despite overall low levels of PR CpG island methylation, there was a significant decrease in methylated CpGs with labour in both preterm (P < 0.05) and term (P < 0.01) groups downstream of the PR-B transcription start site. This methylation change was not associated with altered PR-B expression, but may contribute to the increase in PR-A expression with labour. Chromatin immunoprecipitation revealed that the histone methyltransferase, SET and MYND domain-containing protein 3 (SMYD3), bound to the PR gene at significantly higher levels at the PR-A promoter compared with the PR-B promoter (P < 0.010), with no labour-associated changes observed. The H3K4 demethylase, Jumonji AT-rich interactive domain 1A (JARID1A), also bound to the PR-A, but not to the PR-B promoter prior to term labour, and decreased significantly at the onset of labour (P = 0.014), providing a mechanism for the previously reported increase in H3K4me3 level and PR-A expression with labour. Our studies suggest that epigenetic changes mediated by JARID1A, SMYD3 and DNA methylation may be responsible, at least in part, for the functional progesterone withdrawal that precipitates human labour. © The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

DOI 10.1093/molehr/gau005
Citations Scopus - 7Web of Science - 5
Co-authors John Fitter, Gemma Madsen
2014 Smith CJA, Bensing S, Maltby VE, Zhang M, Scott RJ, Smith R, et al., 'Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis', Pituitary, 17 22-29 (2014) [C1]

Lymphocytic hypophysitis is an organ-specific autoimmune disease characterised by destruction of pituitary hormone-secreting cells due to attack by self-reactive T lymphocytes. Th... [more]

Lymphocytic hypophysitis is an organ-specific autoimmune disease characterised by destruction of pituitary hormone-secreting cells due to attack by self-reactive T lymphocytes. The spectrum of pituitary autoantibodies characterised by indirect immunofluorescence (IF) in these patients has not been substantially defined. The purpose of this study was to determine the spectrum of pituitary autoantibodies in 16 lymphocytic hypophysitis patients. Pituitary sections were prepared from guinea pigs and sera from 16 lymphocytic hypophysitis patients (13 biopsy proven and 3 suspected cases) and 13 healthy controls were evaluated for immunoreactivity to the pituitary tissue by immunofluorescence. A single patient was found to have high titre pituitary autoantibodies against guinea pig pituitary tissue. Immunoreactivity was directed against cells of the intermediate lobe. We present the case report of the patient who is a 24 year old woman that presented with headaches, polyuria and polydipsia. A uniformly enlarged pituitary mass was visible on MRI and a diagnosis of suspected lymphocytic hypophysitis was made. Based on our IF study, we postulate this patient has an autoimmune process directed towards the major cell type in the intermediate lobe, the melanotroph. Pre-adsorption with peptides representing adrenocorticotropic hormone, a-melanocyte stimulating hormone or ß-endorphin did not affect the IF signal suggesting our patient's pituitary autoantibodies may target some other product of Proopiomelanocortin (POMC) processing, such as corticotrophin-like intermediate peptide or ¿-lipoprotein. Alternatively, the autoantibodies may target a peptide completely unrelated to POMC processing. © 2013 Springer Science+Business Media New York.

DOI 10.1007/s11102-013-0461-9
Citations Scopus - 1Web of Science - 1
Co-authors Rodney Scott, Vicki E Maltby
2014 Martin JE, Hure AJ, Macdonald-Wicks L, Smith R, Collins CE, 'Predictors of post-partum weight retention in a prospective longitudinal study', Maternal and Child Nutrition, 10 496-509 (2014) [C1]

© 2012 John Wiley & Sons Ltd.Post-partum weight retention (WR) occurs in 60-80% of women with some retaining =10kg with contributing factors reported as pre-pregnancy body mass i... [more]

© 2012 John Wiley & Sons Ltd.Post-partum weight retention (WR) occurs in 60-80% of women with some retaining =10kg with contributing factors reported as pre-pregnancy body mass index (BMI), gestational weight gain (GWG) and breastfeeding. A longitudinal study of pregnancy, with 12-month post-partum follow-up was conducted to determine factors associated with WR. Pregnant women (n=152) were recruited from the John Hunter Hospital antenatal clinic in New South Wales, Australia. Pre-pregnancy weight was self-reported; weight was measured four times during pregnancy (for GWG) and in the first 12 months post-partum. Infant feeding data were obtained via questionnaires. Breastfeeding was categorised as exclusive, predominant, complementary or not breastfeeding. Linear mixed models tested the predictors of WR, with and without adjustment for potential confounders. Compared with pre-pregnancy weight, 68% of women retained weight at 12 months, median (interquartile range) [4.5kg (2.1-8.9)]. After adjustment, GWG was positively associated with WR (P<0.01), but pre-pregnancy weight did not predict WR. For each additional week of any breastfeeding, 0.04kg less weight was retained. Compared with women who retained weight, those women who did retain had higher rates of exclusive breastfeeding at three months (P<0.05), but the number of weeks of exclusive breastfeeding failed to predict WR for all women. WR following childbirth is common and associated with GWG, while the number of weeks of 'any' breastfeeding contributed to post-partum weight loss. Whether these factors are modifiable strategies to optimise the weight status of women at this life stage requires further research.

DOI 10.1111/j.1740-8709.2012.00437.x
Citations Scopus - 6Web of Science - 5
Co-authors Alexis Hure, Clare Collins, Lesley Wicks
2014 Kandasamy Y, Smith R, Wright IMR, Lumbers ER, 'Reduced nephron endowment in the neonates of Indigenous Australian peoples', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 5 31-35 (2014) [C1]
DOI 10.1017/S2040174413000494
Co-authors Ian Wright
2013 Smith R, Zakar T, Madsen G, 'Mammalian Labor: Variations on a Theme by Amniota', ENDOCRINOLOGY, 154 584-588 (2013) [C1]
DOI 10.1210/en.2012-2262
Co-authors Gemma Madsen
2013 Blumfield ML, Hure AJ, Macdonald-Wicks L, Smith R, Collins CE, 'Micronutrient intakes during pregnancy in developed countries: systematic review and meta-analysis', NUTRITION REVIEWS, 71 118-132 (2013) [C1]
DOI 10.1111/nure.12003
Citations Scopus - 44Web of Science - 40
Co-authors Alexis Hure, Lesley Wicks, Clare Collins
2013 Smith R, Maiti K, Aitken RJ, 'Unexplained antepartum stillbirth: A consequence of placental aging?', PLACENTA, 34 310-313 (2013) [C3]
DOI 10.1016/j.placenta.2013.01.015
Citations Scopus - 7Web of Science - 7
Co-authors John Aitken
2013 Mah BL, Van IJzendoorn MH, Smith R, Bakermans-Kranenburg MJ, 'Oxytocin in postnatally depressed mothers: Its influence on mood and expressed emotion', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 40 267-272 (2013) [C1]

Background: Postnatal depression is common and negatively affects the mother-baby relationship; oxytocin has been found to have positive effects on parenting behavior. We hypothes... [more]

Background: Postnatal depression is common and negatively affects the mother-baby relationship; oxytocin has been found to have positive effects on parenting behavior. We hypothesize that intranasal administration of oxytocin to mothers with depression will influence their parenting related expressed emotion, creating a better basis for sensitive parenting. Methods: Twenty-five postnatally depressed mothers with infants less than one year participated in a randomized, double-blind, placebo controlled within-subject clinical study in 2011. Mothers attended an out-patient perinatal psychiatry setting in NSW, Australia. They received 24. IU of oxytocin alternating with placebo approximately one week apart in random order, prior to completing outcome measures. The outcome measures were the Five Minute Speech Sample, the Self-Assessment Manikin and the Controlled Oral Word Association Test. Results: In the oxytocin condition mothers were sadder (p= .01), and they more often initially described their babies as difficult (p= .038), but they reported that the quality of their relationship with their infant was more positive (p= .036). Limitations: Despite an adequate sample size to answer our central hypothesis, a larger sample may have elucidated a moderating effect of childhood trauma. Conclusion: Oxytocin did not make depressed mothers happier but their perception of the relationship with their baby improved. Treatment with intranasal oxytocin might show some unwanted side-effects in depressed individuals. © 2012 Elsevier Inc.

DOI 10.1016/j.pnpbp.2012.10.005
Citations Scopus - 35
2013 Butler T, Paul J, Europe-Finner N, Smith R, Chan E-C, 'Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractility', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 304 C485-C504 (2013) [C1]
DOI 10.1152/ajpcell.00161.2012
Citations Scopus - 15Web of Science - 12
Co-authors Jonathan Paul
2013 Kandasamy Y, Smith R, Wright IMR, 'Relationship between the Retinal Microvasculature and Renal Volume in Low-Birth-Weight Babies', AMERICAN JOURNAL OF PERINATOLOGY, 30 477-481 (2013) [C1]
DOI 10.1055/s-0032-1326993
Citations Scopus - 2Web of Science - 2
Co-authors Ian Wright
2013 Kandasamy Y, Smith R, Wright IMR, Lumbers ER, 'Extra-uterine renal growth in preterm infants: Oligonephropathy and prematurity', PEDIATRIC NEPHROLOGY, 28 1791-1796 (2013) [C1]
DOI 10.1007/s00467-013-2462-3
Citations Scopus - 14Web of Science - 17
Co-authors Ian Wright
2013 Kandasamy Y, Smith R, Wright I, Hartley L, 'Use of digital retinal imaging in screening for retinopathy of prematurity', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 49 E1-E5 (2013) [C1]
DOI 10.1111/j.1440-1754.2012.02557.x
Citations Scopus - 6Web of Science - 3
Co-authors Ian Wright
2013 Kandasamy Y, Smith R, Wright IMR, Lumbers ER, 'Relationships between glomerular filtration rate and kidney volume in low-birth-weight neonates', JOURNAL OF NEPHROLOGY, 26 894-898 (2013) [C1]
DOI 10.5301/jn.5000220
Citations Scopus - 3Web of Science - 2
Co-authors Ian Wright
2013 Rae K, Weatherall L, Hollebone K, Apen K, McLean M, Blackwell C, et al., 'Developing research in partnership with Aboriginal communities - strategies for improving recruitment and retention', RURAL AND REMOTE HEALTH, 13 (2013) [C2]
Citations Scopus - 3Web of Science - 3
Co-authors Kym Rae, Caroline Blackwell
2013 Chen Y, Allars M, Pan X, Maiti K, Angeli G, Smith R, Nicholson RC, 'Effects of corticotrophin releasing hormone (CRH) on cell viability and differentiation in the human BeWo choriocarcinoma cell line: a potential syncytialisation inducer distinct from cyclic adenosine monophosphate (cAMP)', REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 11 (2013) [C1]
DOI 10.1186/1477-7827-11-30
Citations Scopus - 3Web of Science - 3
Co-authors Giavanna Angeli
2013 Kandasamy Y, Smith R, Wright IMR, 'Measuring Cystatin C to Determine Renal Function in Neonates', PEDIATRIC CRITICAL CARE MEDICINE, 14 318-322 (2013) [C1]
DOI 10.1097/PCC.0b013e318271f4a5
Citations Scopus - 9Web of Science - 8
Co-authors Ian Wright
2013 Torricelli M, Voltolini C, Vellucci FL, Conti N, Bocchi C, Severi FM, et al., 'Fetal gender effects on induction of labor in postdate pregnancies', Reproductive Sciences, 20 670-674 (2013) [C1]

Objective: To determine delivery outcome in women undergoing induction of labor for postdate pregnancy in relation to fetal gender. Study Design: A total of 365 nulliparous and 12... [more]

Objective: To determine delivery outcome in women undergoing induction of labor for postdate pregnancy in relation to fetal gender. Study Design: A total of 365 nulliparous and 127 multiparous women carrying singleton postdate pregnancies with unfavorable cervix were enrolled. Clinical characteristics and delivery outcome were analyzed in relation to fetal gender. Results: Women carrying male fetuses showed higher rate of caesarean section than those carrying females, in both nulliparous and multiparous women. Moreover, women carrying male fetuses presented more frequently with (i) interval between induction of labor and delivery >24 hours (P < .0002); (ii) augmentation of labor after cervical ripening (P < .0391); (iii) meconium-stained liquor (P< .0126); and (iv) higher neonatal weight (P < .0011) than those carrying females. Conclusion: Male fetuses are more likely to be associated with higher rates of cesarean section. In maternal fetal medicine, gender differences may add prognostic information on the delivery outcome in women induced for postdate pregnancy. © The Author(s) 2013.

DOI 10.1177/1933719112462631
Citations Scopus - 2
2012 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Smith R, Simpson SJ, Giles WB, et al., 'Dietary balance during pregnancy is associated with fetal adiposity and fat distribution', American Journal of Clinical Nutrition, 96 1032-1041 (2012) [C1]
Citations Scopus - 33Web of Science - 28
Co-authors Alexis Hure, Lesley Wicks, Clare Collins
2012 Kandasamy Y, Smith R, Wright IM, Hartley L, 'Optic disc measurements in full term infants', British Journal of Ophthalmology, 96 662-664 (2012) [C1]
Citations Scopus - 6Web of Science - 6
Co-authors Ian Wright
2012 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors', Developmental Psychobiology, 54 568-575 (2012) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors Deborah Hodgson, Vicki Clifton, Jay Horvat, Philip Hansbro, Olivia Wynne
2012 Smith R, Maiti K, 'The placenta, a transducer linking maternal nutrition to adult disease in the offspring?', Endocrinology, 153 1572-1574 (2012) [C3]
Citations Scopus - 2Web of Science - 2
2012 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Smith R, Collins CE, 'Systematic review and meta-analysis of energy and macronutrient intakes during pregnancy in developed countries', Nutrition Reviews, 70 322-336 (2012) [C1]
Citations Scopus - 34Web of Science - 29
Co-authors Clare Collins, Lesley Wicks, Alexis Hure
2012 Tolosa Gonzalez JM, Schjenken JE, Clifton VL, Vargas A, Barbeau B, Lowry P, et al., 'The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes', Placenta, 33 933-941 (2012) [C1]
Citations Scopus - 39Web of Science - 38
2012 Kandasamy Y, Smith R, Wright IM, 'Retinal microvascular changes in low-birth-weight babies have a link to future health', Journal of Perinatal Medicine, 40 209-214 (2012) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors Ian Wright
2012 Kandasamy Y, Smith R, Wright IM, 'Oligonephropathy of prematurity', American Journal of Perinatology, 29 115-120 (2012) [C1]
Citations Scopus - 6Web of Science - 6
Co-authors Ian Wright
2012 Kandasamy Y, Smith R, Wright IM, Hartley L, 'Relationship between birth weight and retinal microvasculature in newborn infants', Journal of Perinatology, 32 443-447 (2012) [C1]
Citations Scopus - 5Web of Science - 5
Co-authors Ian Wright
2012 Hure AJ, Collins CE, Giles WB, Wright IM, Smith R, 'Protocol for the Women and Their Children's Health (WATCH) Study: A cohort of pregnancy and beyond', Journal of Epidemiology, 22 267-275 (2012) [C3]
DOI 10.2188/jea.JE20110079
Citations Scopus - 13Web of Science - 12
Co-authors Clare Collins, Alexis Hure, Ian Wright
2012 Smith R, Paul JW, Maiti K, Tolosa Gonzalez JM, Madsen GM, 'Recent advances in understanding the endocrinology of human birth', Trends in Endocrinology & Metabolism, 23 516-523 (2012) [C1]
Citations Scopus - 9Web of Science - 8
Co-authors Gemma Madsen, Jonathan Paul
2012 Hure AJ, Collins CE, Smith R, 'A longitudinal study of maternal folate and vitamin B12 status in pregnancy and postpartum, with the same infant markers at 6 months of age', Maternal and Child Health Journal, 16 792-801 (2012) [C1]
Citations Scopus - 7Web of Science - 7
Co-authors Clare Collins, Alexis Hure
2012 Hure AJ, Collins CE, Giles WB, Paul JW, Smith R, 'Greater maternal weight gain during pregnancy predicts a large but lean fetal phenotype: A prospective cohort study', Maternal and Child Health Journal, 16 1374-1384 (2012) [C1]
DOI 10.1007/s10995-011-0904-8
Citations Scopus - 13Web of Science - 10
Co-authors Clare Collins, Alexis Hure, Jonathan Paul
2012 Abou-Seif C, Shipman KL, Allars MJ, Norris MH, Chen Y, Smith R, Nicholson RC, 'Tissue specific epigenetic differences in CRH gene expression', Frontiers in Bioscience, 17 713-725 (2012) [C1]
Citations Scopus - 7Web of Science - 7
2012 Chai S, Smith R, Zakar T, Mitchell CM, Madsen GM, 'Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-A promoter', Molecular Human Reproduction, 18 401-409 (2012) [C1]
Citations Scopus - 10Web of Science - 7
Co-authors Gemma Madsen
2012 Wadhwa PD, Simhan HN, Entringer S, Buss C, Smith R, Hobel CJ, et al., 'Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and Whites', PLOS One, 7 1-10 (2012) [C1]
Citations Scopus - 2Web of Science - 2
2012 Galal M, Symonds IM, Murray H, Petraglia F, Smith R, 'Postterm pregnancy', Facts, Views & Visions in OBGYN, 4 175-187 (2012) [C1]
Co-authors Ian Symonds
2012 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Smith R, Simpson S, Raubenheimer D, Collins CE, 'The association between the macronutrient content of maternal diet and the adequacy of micronutrients during pregnancy in the Women and Their Children's Health (WATCH) Study', Nutrients, 4 1958-1976 (2012) [C1]
Citations Scopus - 9Web of Science - 8
Co-authors Lesley Wicks, Clare Collins, Alexis Hure
2011 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Patterson AJ, Smith R, Collins CE, 'Disparities exist between National Food Group Recommendations and the dietary intakes of women', BMC Women's Health, 11 37 (2011) [C1]
Citations Scopus - 16Web of Science - 14
Co-authors Clare Collins, Amanda Patterson, Alexis Hure, Lesley Wicks
2011 Paul JW, Maiti K, Read MA, Hure AJ, Smith JI, Chan EC, Smith R, 'Phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium', PLoS ONE, 6 1-7 (2011) [C1]
DOI 10.1371/journal.pone.0021542
Citations Scopus - 9Web of Science - 8
Co-authors Jonathan Paul, Alexis Hure
2011 Torricelli M, Novembri R, Voltolini C, Conti N, Biliotti G, Piccolini E, et al., 'Biochemical and biophysical predictors of the response to the induction of labor in nulliparous postterm pregnancy', American Journal of Obstetrics and Gynecology, 204 e1-e6 (2011) [C1]
DOI 10.1016/j.ajog.2010.08.014
Citations Scopus - 12Web of Science - 3
2011 Maiti K, Paul JW, Read MA, Chan EC, Riley SC, Nahar P, Smith R, 'G-1-activated membrane estrogen receptors mediate increased contractility of the human myometrium', Endocrinology, 152 2448-2455 (2011) [C1]
DOI 10.1210/en.2010-0979
Citations Scopus - 23Web of Science - 19
Co-authors Jonathan Paul
2011 Kandasamy Y, Smith R, Wright IM, 'Retinal microvasculature measurements in full-term newborn infants', Microvascular Research, 82 381-384 (2011) [C1]
Citations Scopus - 6Web of Science - 6
Co-authors Ian Wright
2011 Scott NM, Hodyl NA, Osei-Kumah A, Stark MJ, Smith R, Clifton VL, 'The presence of maternal asthma during pregnancy suppresses the placental pro-inflammatory response to an immune challenge in vitro', Placenta, 32 454-461 (2011) [C1]
Citations Scopus - 13Web of Science - 10
Co-authors Vicki Clifton
2011 Osei-Kumah A, Smith R, Jurisica I, Caniggia I, Clifton VL, 'Sex-specific differences in placental global gene expression in pregnancies complicated by asthma', Placenta, 32 570-578 (2011) [C1]
Citations Scopus - 33Web of Science - 33
2011 Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
DOI 10.1016/j.bbi.2011.03.014
Citations Scopus - 3Web of Science - 3
Co-authors Linkooi Ong, Jay Horvat, Olivia Wynne, Philip Hansbro, Vicki Clifton, Deborah Hodgson
2011 Wynne OL, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner', Stress-the International Journal on the Biology of Stress, 14 247-261 (2011) [C1]
DOI 10.3109/10253890.2010.532576
Citations Scopus - 9Web of Science - 9
Co-authors Jay Horvat, Olivia Wynne, Deborah Hodgson, Philip Hansbro, Vicki Clifton
2011 Rae KM, Weatherall LJ, Naden ML, Slater PE, Smith R, 'Gomeroi Gaaynggal - Moving forward', Aboriginal and Islander Health Worker Journal, 35 28-29 (2011) [C3]
Co-authors Kym Rae
2011 Kandasamy Y, Smith R, Wright IM, Hartley L, 'Pain relief for premature infants during ophthalmology assessment', Journal of AAPOS, 15 276-280 (2011) [C1]
Citations Scopus - 11Web of Science - 9
Co-authors Ian Wright
2011 Chen Y, Allars MJ, Maiti K, Angeli GL, Abou-Seif C, Smith R, Nicholson RC, 'Factors affecting cytotrophoblast cell viability and differentiation: Evidence of a link between syncytialisation and apoptosis', International Journal of Biochemistry & Cell Biology, 43 821-828 (2011) [C1]
DOI 10.1016/j.biocel.2011.02.007
Citations Scopus - 7Web of Science - 5
Co-authors Giavanna Angeli
2010 Sokolowski P, Saison F, Giles W, McGrath SA, Smith D, Smith JI, Smith R, 'Human uterine wall tension trajectories and the onset of parturition', Plos One, 5 1-10 (2010) [C1]
DOI 10.1371/journal.pone.0011037
Citations Scopus - 10Web of Science - 8
2010 Equils O, Nambiar P, Hobel CJ, Smith R, Simmons CF, Vali S, 'A computer simulation of progesterone and Cox2 inhibitor treatment for preterm labor', Plos One, 5 e8502 (2010) [C1]
DOI 10.1371/journal.pone.0008502
Citations Scopus - 9Web of Science - 8
2010 Hodyl NA, Wyper HJ, Osei-Kumah A, Scott NM, Murphy VE, Gibson PG, et al., 'Sex-specific associations between cortisol and birth weight in pregnancies complicated by asthma are not due to differential glucocorticoid receptor expression', Thorax, 65 677-683 (2010) [C1]
DOI 10.1136/thx.2009.123091
Citations Scopus - 17Web of Science - 14
Co-authors Vanessa Murphy, Vicki Clifton, Peter Gibson
2010 Osei-Kumah A, Wark PA, Smith R, Clifton VL, 'Asthma during pregnancy alters immune cell profile and airway epithelial chemokine release', Inflammation Research, 59 349-358 (2010) [C1]
DOI 10.1007/s00011-009-0102-y
Citations Scopus - 7Web of Science - 6
Co-authors Vicki Clifton, Peter Wark
2010 Clifton VL, Hodyl NA, Murphy VE, Giles WB, Baxter RC, Smith R, 'Effect of maternal asthma, inhaled glucocorticoids and cigarette use during pregnancy on the newborn insulin-like growth factor axis', Growth Hormone and IGF Research, 20 39-48 (2010) [C1]
DOI 10.1016/j.ghir.2009.07.004
Citations Scopus - 22Web of Science - 17
Co-authors Vanessa Murphy, Vicki Clifton
2009 Fuery PJ, Smith R, Rae KM, Burgess R, Fuery KL, 'Morality, duty, and the arts in health: A project on Aboriginal underage pregnancy', Arts & Health: An International Journal for Research, Policy and Practice, 1 36-47 (2009) [C1]
DOI 10.1080/17533010802528025
Co-authors Kym Rae
2009 Macintyre DA, Smith R, Yeo G, Kwek K, Bisits AM, Chan EC, 'Spontaneous and induced labour are associated with different myometrial proteomes in the human', Proteomics Clinical Applications, 3 288-298 (2009) [C1]
DOI 10.1002/prca.200800050
Citations Scopus - 1Web of Science - 1
2009 Merlino A, Welsh T, Erdonmez T, Madsen GM, Zakar T, Smith R, et al., 'Nuclear progesterone receptor expression in the human fetal membranes and decidua at term before and after labor', Reproductive Sciences, 16 357-363 (2009) [C1]
DOI 10.1177/1933719108328616
Citations Scopus - 28Web of Science - 25
Co-authors Gemma Madsen
2009 Clifton VL, Engel PJ, Smith R, Gibson PG, Brinsmead MW, Giles WB, 'Maternal and neonatal outcomes of pregnancies complicated by asthma in an Australian population', Australian and New Zealand Journal of Obstetrics and Gynaecology, 49 619-626 (2009) [C1]
DOI 10.1111/j.1479-828x.2009.01077.x
Citations Scopus - 33Web of Science - 31
Co-authors Vicki Clifton, Peter Gibson
2009 Tyson EK, Smith R, Read MA, 'Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy', Endocrinology, 150 5617-5625 (2009) [C1]
DOI 10.1210/en.2009-0348
Citations Scopus - 20Web of Science - 16
2009 Smith R, Smith JI, Shen XB, Engel PJ, Bowman M, McGrath SA, et al., 'Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor', Journal of Clinical Endocrinology & Metabolism, 94 2066-2074 (2009) [C1]
DOI 10.1210/jc.2008-2257
Citations Scopus - 89Web of Science - 79
Co-authors Patrick Mcelduff, Maria Bowman
2009 Scott NM, Hodyl NA, Murphy VE, Osei-Kumah A, Wyper H, Hodgson DM, et al., 'Placental cytokine expression covaries with maternal asthma severity and fetal sex', Journal of Immunology, 182 1411-1420 (2009) [C1]
Citations Scopus - 44Web of Science - 39
Co-authors Vicki Clifton, Deborah Hodgson, Vanessa Murphy
2009 Carlin A, Norman J, Cole S, Smith R, 'Tocolytics and preterm labour: Whether to treat or not is the real dilemma, not which drug to use', British Medical Journal, 339 727-728 (2009) [C3]
DOI 10.1136/bmj.b195
Citations Scopus - 7Web of Science - 4
2009 Rae KM, Weatherall LJ, Smith R, Mackay PJ, 'The birth of Gomeroi Gaaynggal', Aboriginal & Islander Health Worker Journal, 33 9-11 (2009) [C1]
Co-authors Kym Rae
2009 Hure AJ, Young AF, Smith R, Collins CE, 'Diet and pregnancy status in Australian women', Public Health Nutrition, 12 853-861 (2009) [C1]
DOI 10.1017/s1368980008003212
Citations Scopus - 46Web of Science - 34
Co-authors Clare Collins, Alexis Hure, Anne Young
2008 Osei-Kumah A, Smith R, Clifton VL, 'Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma', Cytokine, 43 187-193 (2008) [C1]
DOI 10.1016/j.cyto.2008.05.008
Citations Scopus - 10Web of Science - 9
Co-authors Vicki Clifton
2008 Hure AJ, Smith R, Collins CE, 'A recruiting failure turned success', BMC Health Services Research, 8 1-6 (2008) [C1]
DOI 10.1186/1472-6963-8-64
Citations Scopus - 11Web of Science - 13
Co-authors Clare Collins, Alexis Hure
2008 Leong A, Norman JE, Smith R, 'Vascular and myometrial changes in the human uterus at term', Reproductive Sciences, 15 59-65 (2008) [C1]
DOI 10.1177/1933719107309646
Citations Scopus - 24Web of Science - 20
2008 Uh A, Nicholson RC, Gonzalez GV, Simmons CF, Gombart A, Smith R, Equils O, 'Lipopolysaccharide stimulation of trophoblasts induces corticotropin-releasing hormone expression through MyD88', American Journal of Obstetrics and Gynecology, 199 317.e1-317.e6 (2008) [C1]
DOI 10.1016/j.ajog.2008.06.091
Citations Scopus - 15Web of Science - 5
2008 Engel PJ, Smith R, Brinsmead MW, Bowe SJ, Clifton VL, 'Male sex and pre-existing diabetes are independent risk factors for stillbirth', Australian & New Zealand Journal of Obstetrics & Gynaecology, 48 375-383 (2008) [C1]
DOI 10.1111/j.1479-828x.2008.00863.x
Citations Scopus - 28Web of Science - 28
Co-authors Vicki Clifton
2008 Macintyre DA, Tyson EK, Read MA, Smith R, Yeo G, Kwek K, Chan EC, 'Contraction in human myometrium is associated with changes in small heat shock proteins', Endocrinology, 149 245-252 (2008) [C1]
DOI 10.1210/en.2007-0662
Citations Scopus - 27Web of Science - 25
2008 Tyson EK, Macintyre DA, Smith R, Chan EC, Read MA, 'Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy', Endocrinology, 149 6157-6165 (2008) [C1]
DOI 10.1210/en.2008-0593
Citations Scopus - 17Web of Science - 15
2008 Johnson RF, Rennie N, Murphy VE, Zakar T, Clifton VL, Smith R, 'Expression of glucocorticoid receptor messenger ribonucleic acid transcripts in the human placenta at term', Journal of Clinical Endocrinology & Metabolism, 93 4887-4893 (2008) [C1]
DOI 10.1210/jc.2008-1077
Citations Scopus - 21Web of Science - 19
Co-authors Vicki Clifton, Vanessa Murphy
2008 Lau SL, McGrath S, Evain-Brion D, Smith R, 'Clinical and biochemical improvement in acromegaly during pregnancy', JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 31 255-261 (2008) [C1]
Citations Scopus - 22Web of Science - 17
2007 Tolosa Gonzalez JM, Schjenken JE, Civiti TD, Clifton VL, Smith R, 'Column-based method to simultaneously extract DNA, RNA, and proteins from the same sample', Biotechniques, 43 799-804 (2007) [C1]
DOI 10.2144/000112594
Citations Scopus - 26Web of Science - 23
Co-authors Vicki Clifton
2007 Macintyre DA, Chan EC, Smith R, 'Myometrial activation: Coordination, connectivity and contractility', Fetal and Maternal Medicine Review, 18 333-356 (2007) [C1]
DOI 10.1017/s0965539507002033
Citations Scopus - 2
2007 Smith R, Nicholson RC, 'Corticotrophin releasing hormone and the timing of birth', Frontiers in Bioscience, 12 912-918 (2007) [C1]
DOI 10.2741/2113
Citations Scopus - 60Web of Science - 59
2007 Madsen GM, Macintyre DA, Mesiano S, Smith R, 'Progesterone receptor or cytoskeletal protein?', Reproductive Sciences, 14 217-222 (2007) [C1]
DOI 10.1177/1933719107302380
Citations Scopus - 10Web of Science - 9
Co-authors Gemma Madsen
2007 Macintyre DA, Smith R, Chan EC, 'Differential enrichment of high- and low-molecular weight proteins and concurrent RNA extraction (vol 359, pg 274, 2006)', Analytical Biochemistry, 364 95 (2007) [C3]
DOI 10.1016/j.ab.2007.01.042
2007 Smith R, Van Helden DF, Hirst JJ, Zakar T, Read MA, Chan EC, et al., 'Pathological interactions with the timing of birth and uterine activation', Australian & New Zealand Journal of Obstetrics & Gynaecology, 47 430-437 (2007) [C1]
DOI 10.1111/j.1479-828x.2007.00775.x
Citations Scopus - 11Web of Science - 10
Co-authors Hannah Palliser, Jon Hirst, Dirk Vanhelden
2007 Smith R, 'Parturition', New England Journal of Medicine, 356 271-283 (2007) [C1]
DOI 10.1056/NEJMra061360
Citations Scopus - 249Web of Science - 213
2007 Murphy VE, Fittock RJ, Zarzycki PK, Delahunty MM, Smith R, Clifton VL, 'Metabolism of synthetic steroids by the human placenta', Placenta, 28 39-46 (2007) [C1]
DOI 10.1016/j.placenta.2005.12.010
Citations Scopus - 47Web of Science - 37
Co-authors Vicki Clifton, Vanessa Murphy
2006 Osei-Kumah A, Ammit AJ, Smith R, Ge Q, Clifton VL, 'Inflammatory mediator release in normal bronchial smooth muscle cells is altered by pregnant maternal and fetal plasma independent of asthma', Placenta, 27 847-852 (2006) [C1]
DOI 10.1016/j.placenta.2005.08.007
Citations Scopus - 9Web of Science - 8
Co-authors Vicki Clifton
2006 Murphy VE, Smith R, Giles WB, Clifton VL, 'Endocrine regulation of human fetal growth: The role of the mother, placenta, and fetus', Endocrine Reviews, 27 141-169 (2006) [C1]
DOI 10.1210/er.2005-0011
Citations Scopus - 262Web of Science - 234
Co-authors Vanessa Murphy, Vicki Clifton
2006 Gill AW, Madsen GM, Knox M, Bisits AM, Giles WB, Tudehope D, et al., 'Neonatal neurodevelopmental outcomes following tocolysis with glycerol trinitrate patches', American Journal of Obstetrics and Gynecology, 195 484-487 (2006) [C1]
DOI 10.1016/j.ajog.2006.01.103
Citations Scopus - 5Web of Science - 6
Co-authors Gemma Madsen
2006 Power ML, Bowman M, Smith R, Ziegler TE, Layne DG, Schulkin J, Tardif SD, 'Pattern of maternal serum corticotropin-releasing hormone concentration during pregnancy in the common marmoset (Callithrix jacchus)', American Journal of Primatology, 68 181-188 (2006) [C1]
DOI 10.1002/ajp.20215
Citations Scopus - 14Web of Science - 12
Co-authors Maria Bowman
2006 Shipman KL, Robinson PJ, King BR, Smith R, Nicholson RC, 'Identification of a family of DNA-binding proteins with homology to RNA splicing factors', Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire, 84 9-19 (2006) [C1]
DOI 10.1139/o05-139
Citations Scopus - 4Web of Science - 4
Co-authors Bruce King
2006 Murphy VE, Johnson RF, Wang YC, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'Proteomic study of plasma proteins in pregnant women with asthma', Respirology, 11 41-48 (2006) [C1]
DOI 10.1111/j.1440-1843.2006.00782.x
Citations Scopus - 20Web of Science - 18
Co-authors Peter Gibson, Vicki Clifton, Vanessa Murphy
2006 Zarzycki PK, Kulhanek KM, Smith R, Clifton VL, 'Determination of steroids in human plasma using temperature-dependent inclusion chromatography for metabolomic investigations', Journal of Chromatography A, 1104 203-208 (2006) [C1]
DOI 10.1016/j.chroma.2005.11.119
Citations Scopus - 24Web of Science - 27
Co-authors Vicki Clifton
2006 Macintyre DA, Smith R, Chan EC, 'Differential enrichment of high- and low-molecular weight proteins and concurrent RNA extraction', Analytical Biochemistry, 359 274-276 (2006) [C1]
DOI 10.1016/j.ab.2006.07.044
Citations Scopus - 5Web of Science - 4
2005 Murphy VE, Gibson PG, Smith R, Clifton VL, 'Asthma during pregnancy: mechanisms and treatment implications', European Respiratory Journal, 25 731-750 (2005) [C1]
DOI 10.1183/09031936.05.00085704
Citations Scopus - 93Web of Science - 75
Co-authors Vanessa Murphy, Peter Gibson, Vicki Clifton
2005 Clifton VL, Crompton R, Read MA, Gibson PG, Smith R, Wright IM, 'Microvascular Effects of Corticotropin-Releasing Hormone in Human Skin Vary in Relation to Estrogen Concentration During the Menstrual Cycle', Journal of Endocrinology, 186 69-76 (2005) [C1]
DOI 10.1677/joe.1.06030
Citations Scopus - 14Web of Science - 11
Co-authors Peter Gibson, Vicki Clifton, Ian Wright
2005 Murphy VE, Johnson RF, Wang Y-C, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'The Effect of Maternal Asthma on Placental and Cord Blood Protein Profiles', Society for Gynecological Investigation Journal, 12 349-355 (2005) [C1]
DOI 10.1016/j.jsgi.2005.01.024
Citations Scopus - 18Web of Science - 17
Co-authors Vanessa Murphy, Vicki Clifton, Peter Gibson
2005 Zarzycki P, Kulhanek K, Smith R, Bartozsuk M, Lamparczyk H, 'Planar Chromatography shows potential to kick its column counterpart out of the limelight', LC GC North America:, 23 2-7 (2005) [C3]
2005 Zarzycki PK, Kulhanek KM, Smith R, Bartoszuk MA, Lamparczyk H, 'Planar chromatography versus column chromatography: A performance comparison', Lc Gc North America, 23 286-300 (2005) [C1]
Citations Scopus - 13Web of Science - 12
2005 Bisits AM, Smith R, Mesiano S, Yeo GS, Kwek K, Macintyre DA, Chan EC, 'Inflammatory Aetiology of Human Myometrial Activation Tested Using Directed Graphs', PLoS Computational Biology, 1 0132-136 (2005) [C1]
DOI 10.1371/journal.pcbi.0010019
Citations Scopus - 33Web of Science - 33
2004 Madsen GM, Zakar T, Ku CY, Sanborn B, Smith R, Mesiano S, 'Prostaglandins Differentially Modulate Progesterone Receptor-A and -B Expression in Human Myometrial Cells: Evidence for Prostaglandin-Induced Functional Progesterone Withdrawal', Endocrinology and Metabolism, 89 1010-1013 (2004) [C1]
DOI 10.1210/jc.2003-031037
Citations Scopus - 74Web of Science - 60
Co-authors Gemma Madsen
2004 Ni X, Hou Y, King BR, Tang X, Read MA, Smith R, Nicholson RC, 'Estrogen Receptor-Mediated Down-Regulation of Corticotropin-Releasing Hormone Gene Expression Is Dependant on a Cyclic Adenosine 3', 5'-Monophosphate Syncytiotrophoblast Cells', The Journal of Clinical Endocrinology & Metabolism, 89 2312-2318 (2004) [C1]
DOI 10.1210/jc.2003-030948
Citations Scopus - 29Web of Science - 29
Co-authors Bruce King
2004 Walker FR, Brogan AE, Smith R, Hodgson DM, 'A profile of the immediate endocrine, metabolic and behavioural responses following a dual exposure to endotoxin in early life', Physiology & Behavior, 83 495-504 (2004) [C1]
DOI 10.1016/j.physbeh.2004.08.030
Citations Scopus - 21Web of Science - 20
Co-authors Rohan Walker, Deborah Hodgson
2004 Bisits AM, Madsen GM, Knox M, Gill AW, Smith R, Yeo GS, et al., 'The Randomized Nitric Oxide Tocolysis Trial (RNOTT) for the treatment of preterm labor', American Journal of Obstetrics and Gynecology, 191 683-690 (2004) [C1]
DOI 10.1016/j.ajog.2004.02.019
Citations Scopus - 37Web of Science - 25
Co-authors Gemma Madsen
2004 Madsen GM, Zakar T, Manuelpillai U, Wallace E, Kwek K, Yeo GS, et al., 'Intracrine Control of Estrogen Action in Human Gestational Tissues at Parturition', Society for Gynecologic Investigation. Journal, 11 213-219 (2004) [C1]
DOI 10.1016/j.jsgi.2003.12.003
Citations Scopus - 5Web of Science - 5
Co-authors Gemma Madsen
2004 Nicholson RC, King BR, Smith R, 'Complex Regulatory Interactions Control CRH Gene Expression', Frontiers in Bioscience, 9 32-39 (2004) [C1]
DOI 10.2741/1204
Citations Scopus - 37Web of Science - 34
Co-authors Bruce King
2004 Ni X, Hou Y, Yang R, Tang X, Smith R, Nicholson R, 'Progesterone Receptors A and B differentially modulate corticotrophin-releasing hormone gene expression in placental cells through a cyclic adenosine 3', 5'-monophosphate regulatory element', Cellular And Molecular Life Sciences, 61 1114-1122 (2004) [C1]
DOI 10.1007/s00018-004-4030-2
Citations Scopus - 36Web of Science - 34
2004 Cole S, Smith R, Giles WB, 'Tocolysis: Current controversies, future directions', Current Opinion in Investigational Drugs, 5 (2004) [C1]
Citations Scopus - 6
2003 Crompton R, Clifton VL, Bisits AM, Read MA, Smith R, Wright IM, 'Corticotropin-releasing hormone causes vasodilation in human skin via mast cell-dependent pathways', Journal Of Clinical Endocrinology And Metabolism, 88 5427-5432 (2003) [C1]
DOI 10.1210/jc.2003-030377
Citations Scopus - 62Web of Science - 52
Co-authors Vicki Clifton, Ian Wright
2003 Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Bisits AM, et al., 'Maternal Asthma Is Associated with Reduced Female Fetal Growth', American Journal of Respiratory & Critical Care Medicine, 168 1317-1323 (2003) [C1]
DOI 10.1164/rccm.200303-374OC
Citations Scopus - 138Web of Science - 128
Co-authors Peter Gibson, Vicki Clifton, Vanessa Murphy
2003 Smith R, Mesiano S, Clifton V, Chan EC, Zakar T, Nicholson R, et al., 'The pathway to human birth', Cuadernos de Medicina Reproductiva, 9 43-51 (2003)

Preterm labour remains a major obstetric problem with only poor methods for prediction of preterm birth and treatments of preterm labour with limited efficacy. Regulation of human... [more]

Preterm labour remains a major obstetric problem with only poor methods for prediction of preterm birth and treatments of preterm labour with limited efficacy. Regulation of human parturition is demonstrably different from that in most animals restricting opportunities for relevant research. Recent work suggests a placental clock mechanism regulating the length of pregnancy through the production of the placental peptide Corticotrophin Releasing Hormone. At the end of pregnancy most animals initiate labour with a fall in circulating progesterone concentrations but this does not happen in humans. In humans a functional progesterone withdrawal is initiated by a change in myometrial expression of progesterone receptors, specifically increase expression of the PRA isoforms, which is a dominant repressor of the activating receptor PRB. This new knowledge may help design better strategies for prediction and treatment of preterm labour.

2003 Smith R, Mesiano S, Clifton VL, Chan EC, Zakar T, Nicholson RC, et al., 'The Pathway to Human Birth', Cuadernos de Medicina Reproductiva, 9 43-51 (2003) [C1]
Co-authors Vicki Clifton
2002 Clifton VL, Crompton R, Smith R, Wright ML, 'Microvascular Effects of CRH in Human Skin Vary in Relation to Gender', The Journal of Clinical Endocrinology & Metabolism, 87(1) 267-270 (2002) [C1]
DOI 10.1210/jc.87.1.267
Citations Scopus - 28Web of Science - 25
Co-authors Ian Wright, Vicki Clifton
2002 Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL, 'Reduced 11 -Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated with Decreased Birth Weight Centile in Pregnancies Complicated by Asthma', The Journal of Clinical Endocrinology & Metabolism, 87(4) 1660-1668 (2002) [C1]
Citations Scopus - 99Web of Science - 94
Co-authors Peter Gibson, Vanessa Murphy, Vicki Clifton
2002 Ni X, Nicholson RC, King B, Chan EC, Read M, Smith R, 'Estrogen Represses whereas the Estrogen-Antagonist ICI 182780 Stimulates Placental CRH Gene Expression', Journal of Clinical Endocrinology and Metabolism, 87(8) 3774-3778 (2002) [C1]
Citations Scopus - 40Web of Science - 34
Co-authors Bruce King
2002 Chan EC, Fraser S, Yin S, Yeo G, Kwek K, Fairclough RJ, Smith R, 'Human myometrial genes are differentially expressed in labour', Journal of Clinical Endocrinology and Metabolism, 87 2435-2441 (2002) [C1]
DOI 10.1210/jc.87.6.2435
Citations Scopus - 67Web of Science - 59
2002 Mesiano S, Chan EC, Fitter JT, Kwek K, Yeo G, Smith R, 'Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor-A expression in the myometrium', Journal of Clinical Endocrinology and Metabolism, 87 2924-2930 (2002) [C1]
Citations Scopus - 230Web of Science - 203
Co-authors John Fitter
2002 Clifton VL, Wallace EM, Smith R, 'Short-term effects of glucocorticoids in the human fetal-placental circulation in vitro', Journal of Clinical Endocrinology and Metabolism, 87 2838-2842 (2002) [C1]
Citations Scopus - 26Web of Science - 24
Co-authors Vicki Clifton
2002 McGrath S, McLean M, Smith D, Bisits A, Giles W, Smith R, 'Maternal serum activin A, inhibin A, and follistatin in pregnancies with appropriately grown and small-for-gestational-age fetuses classified by umbilical artery Doppler ultrasound', American Journal of Obstetrics and Gynecology, 186 283-287 (2002)

OBJECTIVE: The purpose of this study was to examine the relationship of maternal serum activin A, inhibin A, and follistatin with fetal growth and placental function. STUDY DESIGN... [more]

OBJECTIVE: The purpose of this study was to examine the relationship of maternal serum activin A, inhibin A, and follistatin with fetal growth and placental function. STUDY DESIGN: Inhibin A, activin A, and follistatin were measured in maternal serum that was stored from normally grown (control subjects, n = 50) and small-for-gestational-age pregnancies (n = 49), prospectively classified as normal small-for-gestational-age pregnancy or fetal growth-restricted pregnancy with the use of umbilical artery Doppler ultrasound. RESULTS: Activin A and inhibin A were significantly increased in fetal growth-restricted pregnancies compared with control subjects (activin A: regression coefficient, 0.54, P < .001; inhibin A: regression coefficient, 0.47, P = .003). The activin:follistatin ratio was significantly higher in fetal growth-restricted pregnancies compared with control subjects (P < .001). There were no significant differences between analyte levels of normal small-for-gestational-age pregnancies and control subjects. CONCLUSION: Maternal serum activin A, inhibin A, and activin:follistatin ratio are raised in fetal growth-restricted pregnancies but not in normal small-for-gestational age pregnancies. This provides further evidence of the difference between subgroups within small-for-gestational-age pregnancies and emphasizes the need to stratify for this in research.

DOI 10.1067/mob.2002.119777
Citations Scopus - 27
2002 Smith R, Mesiano S, McGrath SA, 'Hormone trajectories leading to human birth', Regulatory Peptides, 108 159-164 (2002) [C1]
Citations Scopus - 93Web of Science - 81
2002 Holloway AC, Howe DC, Chan G, Clifton VL, Smith R, Challis JRG, 'Urocortin: A mechanism for the sustained activation of the HPA axis in the late-gestation ovine fetus?', American Journal of Physiology - Endocrinology and Metabolism, 283 (2002)

We hypothesized that urocortin might be produced in the pituitary of the late-gestation ovine fetus in a manner that could contribute to the regulation of ACTH output. We used in ... [more]

We hypothesized that urocortin might be produced in the pituitary of the late-gestation ovine fetus in a manner that could contribute to the regulation of ACTH output. We used in situ hybridization and immunohistochemistry to identify urocortin mRNA and protein in late-gestation fetal pituitary tissue. Levels of urocortin mRNA rose during late gestation and were associated temporally with rising concentrations of pituitary proopiomelanocortin (POMC) mRNA. Urocortin was localized both to cells expressing ACTH and to non-ACTH cells by use of dual immunofluorescence histochemistry. Transfection of pituitary cultures with urocortin antisense probe reduced ACTH output, whereas added urocortin stimulated ACTH output from cultured pituitary cells. Cortisol infusion for 96 h in chronically catheterized late-gestation fetal sheep significantly stimulated levels of pituitary urocortin mRNA. We conclude that urocortin is expressed in the ovine fetal pituitary and localizes with, and can stimulate output of, ACTH. Regulation of urocortin by cortisol suggests a mechanism to override negative feedback and sustain feed-forward of fetal hypothalamic-pituitary-adrenal function, leading to birth.

Citations Scopus - 11
2002 King B, Smith R, Nicholson RC, 'Novel glucocorticoid and cAMP interactions on the CRH gene promoter', Molecular and Cellular Endocrinology, 194 19-28 (2002) [C1]
Citations Scopus - 59Web of Science - 54
Co-authors Bruce King
2002 O'Dwyer DT, Clifton VL, Hall AL, Smith R, Robinson P, Crock PA, 'Pituitary Autoantibodies in Lymphocytic Hypophysitis Target Both - and - Enolase - A Link with Pregnancy?', Archives of Physiology and Biochemistry, 110(1-2) 94-98 (2002) [C1]
Citations Scopus - 52
Co-authors Vicki Clifton
2002 Schwartz J, Revskoy S, Redei E, Clifton VL, Smith R, Cherny R, 'Corticotrophs and peptides', Archives of Physiology and Biochemistry, 110 146-153 (2002) [C1]
Co-authors Vicki Clifton
2002 McGrath SA, Smith R, 'Prediction of preterm delivery using plasma corticotrophin-releasing hormone and other biochemical variables', Annals of Medicine, 34 28-36 (2002) [C1]
Citations Scopus - 7Web of Science - 6
2002 Young I, Chan EC, Smith R, Chrousos GP, Veldhuis JD, Canny BJ, 'Effect of antalarmin, a novel corticotrophin-releasing hormone antagonist, on the dynamic function of the ovine fetal hypothalamo-pituitary-adrenal axis', Neuroendocrinology, 76 47-54 (2002) [C1]
DOI 10.1159/000063683
Citations Scopus - 5Web of Science - 5
2002 Holloway AC, Howe DC, Chan G, Clifton VL, Smith R, Challis RG, 'Urocortin: A mechanism for the sustained activation of the HPA axis in the late gestation ovine fetus?', American Journal of Physiology ¿ Endocrinology and Metabolism, 283 165-171 (2002) [C1]
Citations Web of Science - 8
Co-authors Vicki Clifton
2002 Zarzycki PK, Kulhanek KM, Smith R, 'Chromatographic behaviour of selected steroids and their inclusion complexes with beta-cyclodextrin on octadecylsilica stationary phases with different carbon loads', Journal of Chromatography A, 71-78 (2002) [C1]
Citations Scopus - 18Web of Science - 18
2002 McGrath SA, McLean M, Smith D, Bisits AM, Giles WB, Smith R, 'Maternal plasma corticotropin-releasing hormone trajectories vary depending on the cause of preterm delivery', American Journal of Obstetrics & Gynecology, 186 257-260 (2002) [C1]
Citations Web of Science - 31
2001 Zarzycki P, Smith R, 'Separation of steriods using temperature-dependent inclusion chromatography', Journal of Chromatography A, 912 45-52 (2001) [C1]
Citations Scopus - 28Web of Science - 29
2001 King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta (vol 22, pg 795, 2001)', PEPTIDES, 22 1939-+ (2001)
DOI 10.1016/S0196-9781(01)00485-5
Co-authors Bruce King
2001 King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta.', Peptides, 22 1941-1947 (2001)

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to th... [more]

Corticotrophin-releasing hormone (CRH) is a 41 amino acid neuropeptide that is expressed in the hypothalamus and the human placenta. Placental CRH production has been linked to the determination of gestational length in the human. Although encoded by a single copy gene, CRH expression in the placenta is regulated differently to the hypothalamus. Glucocorticoids stimulate CRH promoter activity in the placenta but inhibit it's activity in the hypothalamus, via mechanisms involving different regions of the CRH promoter. We discuss how various stimuli alter CRH promoter activity and why these responses are unique to the placenta.

DOI 10.1016/S0196-9781(01)00486-7
Citations Scopus - 9
Co-authors Bruce King
2001 King BR, Smith R, Nicholson RC, 'The regulation of human corticotrophin-releasing hormone gene expression in the placenta', Peptides, 22 795-801 (2001) [C1]
Citations Scopus - 34Web of Science - 12
Co-authors Bruce King
2001 Bowman ME, Lopata A, Jaffe RB, Golos TG, Wickings J, Smith R, 'Circannual changes in the secondary sexual adornments of semifree-ranging male and female mandrills (Mandrillus sphinx)', American Journal of Primatology, 53 109-121 (2001)

Male mandrills (Mandrillus sphinx) have spectacular secondary sexual adornments. These include red and blue sexual skin on the face, rump, and genitalia; a sternal scent-marking g... [more]

Male mandrills (Mandrillus sphinx) have spectacular secondary sexual adornments. These include red and blue sexual skin on the face, rump, and genitalia; a sternal scent-marking gland; and a "fatted" rump. Mandrills are seasonal breeders, and in other seasonally-breeding primate species members of both sexes may show increased expression of secondary sexual characteristics during the mating season. We examined changes in male secondary sexual adornments and testosterone levels, in relation to seasonal changes in the female reproductive cycle and sexual skin morphology, in two semifree-ranging mandrill groups. Females showed circannual changes in sexual skin tumescence, and periods of tumescence peaked from May-July in a long-established group. However, formation of a second, smaller group, two years previous to commencement of the study, disrupted the seasonal pattern of sexual skin tumescence and births. As the groups occupied adjacent enclosures, it appears that social factors, as well as physical environment, affected the seasonal patterning of reproduction in females. Male mandrills, by contrast, did not exhibit marked circannual changes in secondary sexual traits. Although adult male testicular volume and circulating testosterone levels increased significantly during the mating season, sexual skin coloration and rump "fattedness" showed no consistent changes with season. There was some evidence to suggest that maturing males (ages 5-8 yr) showed increased development of red sexual skin during mating periods, but once males had fully developed secondary sexual adornments, they remained stable throughout the year. The possible reasons for this are discussed in relation to intermale competition and social organization in mandrills. © 2001 Wiley-Liss, Inc.

DOI 10.1002/1098-2345(200103)53:3&lt;109::AID-AJP2&gt;3.0.CO;2-I
Citations Scopus - 36
2001 McGrath SA, Smith R, 'Corticotrophin-releasing hormone and parturition', Clinical Endocrinology, 55 593-595 (2001) [C2]
Citations Scopus - 11Web of Science - 8
2001 Gu Q, Clifton VL, Schwartz J, Madsen G, Sha JY, Smith R, 'Characterization of urocortin in human pregnancy', CHINESE MEDICAL JOURNAL, 114 618-622 (2001)
Citations Scopus - 7Web of Science - 7
2001 King BR, Nicholson RC, Smith R, 'Placental Corticotrophin-releasing Hormone, Local Effects and Fetomaternal Endocrinology', Stress: the international journal on the biology of stress, 4 219-233 (2001) [C3]
Citations Scopus - 11
Co-authors Bruce King
2001 Chan EC, Smith R, 'Lessons in Labour', Trends in Endocrinology & Metabolism, 12 44-46 (2001) [C1]
Citations Scopus - 1
2001 Clifton VL, Giles WB, Smith R, Bisits AM, Hempenstall P, Kessell C, Gibson PG, 'Alterations of Placental Vascular Function in Asthmatic Pregnancies', American Journal of Respiratory and Critical Care Medicine, 164 546-553 (2001) [C1]
Citations Scopus - 44Web of Science - 36
Co-authors Vicki Clifton, Peter Gibson
2001 Leung T, Chung T, Madsen GM, Lam P, Sahota D, Smith R, 'Rate of rise in maternal plasma corticotrohpin-releasing hormone and its relation to gestational length', BJOG: An international Journal of Obstetrics and Gynaecology, 108 527-532 (2001) [C1]
Citations Scopus - 20Web of Science - 15
Co-authors Gemma Madsen
2001 McLean M, Smith R, 'Corticotrophin-releasing hormone and human parturition', Reproduction, 121 493-501 (2001) [C1]
Citations Scopus - 105Web of Science - 80
2001 Bowman M, Lopata A, Jaffe R, Golos T, Wickings J, Smith R, 'Corticotropin-Releasing Hormone-Binding Protein in Primates', American Journal of Primatology, 53 123-130 (2001) [C1]
Citations Scopus - 33Web of Science - 26
Co-authors Maria Bowman
2000 McCluskey A, Finn M, Bowman M, Keller PA, Smith R, '2,7-dimethylthiazolo[4,5-d] pyradazine-4-(5H)-thione: a corticotrophin releasing hormone type 1 receptor agonist', Australian journal of chemistry, 905-908 (2000) [C1]
Citations Scopus - 3Web of Science - 2
Co-authors Adam Mccluskey, Maria Bowman
2000 Cheng Y, Nicholson RC, King BR, Chan EC, Fitter JT, Smith R, 'Corticotropin-Releasing Hormone Gene Expresssion in Primary Placental Cells is Modulated by Cyclic Adenosine 3',5'-Monophosphate', The Journal of Clinical Endocrinology & Metabolism, 85 1239-1244 (2000) [C1]
Citations Scopus - 34Web of Science - 35
Co-authors John Fitter, Bruce King
2000 McLean M, Bowman M, Clifton VL, Smith R, Grossman AB, 'Expression of the Heme Oxygenase-Carbon Monoxide Signalling system in Human Placenta', The Journal of Clinical Endocrinology & Metabolism, 85 2345-2349 (2000) [C1]
Citations Scopus - 43Web of Science - 37
Co-authors Maria Bowman, Vicki Clifton
2000 Cheng Y, Nicholson RC, King BR, Chan EC, Fitter JT, Smith R, 'Glucocorticoid stimulation of Corticiotrophin-releasing hormone gene expression requires a Cyclic Adenosine 3',5'-Monophosphate regulatory element in human primary Placental Cytotrophoblast Cells', The journal of Clinical Endocrinology And Metabolism, 85 (2000) [C1]
Citations Scopus - 66Web of Science - 61
Co-authors John Fitter, Bruce King
2000 Clifton VL, Qing G, Murphy VE, Schwartz J, Madsen GM, Smith R, 'Localization and Characterization of Urocortin during Human Pregancy', Placenta, 21 782-788 (2000) [C1]
Citations Scopus - 44Web of Science - 39
Co-authors Vanessa Murphy, Vicki Clifton, Gemma Madsen
2000 Donoghue J, Leitch I, Boura A, Walters W, Giles W, Smith R, Read M, 'Fetal placental vascular responses to corticotropin-releasing hormone in vitro. Effects Of variation in oxygen tension', Placenta, 21 711-717 (2000) [C1]
Citations Scopus - 12Web of Science - 9
2000 Leung TN, Chung T, Madsen GM, Lam C, Lam P, Walters W, Smith R, 'Analysis of mid-trimester corticotrophin-releasing hormone and a-fetoprotein concentrations for predicting pre-eclampsia', Human Reproduction, 15 1813-1818 (2000) [C1]
Citations Scopus - 25Web of Science - 19
Co-authors Gemma Madsen
2000 Smith R, 'An end to violence: I should only make myself ridiculous in my own eyes if I clung to life', Futures, Nature, 406 (2000) [C3]
2000 Giles W, Bisits A, Knox M, Madsen GM, Smith R, 'The effect of fetal fibronectin testing on admissions to a tertiary maternal-fetal medicine unit and cost savings', American Journal of Obstetrics and Gynecology, 182 439-442 (2000) [C1]
Co-authors Gemma Madsen
1999 Smith R, 'Corticotropin-releasing hormone and the fetoplacental clock: an Australian perspective', Americal Journal of Obstetrics and Gynecology, Jan 180(1 Pt 3) 269-271 (1999) [C1]
Citations Scopus - 5Web of Science - 3
1999 McLean M, Bisits AM, Davies J, Walters W, Hackshaw A, De Voss K, Smith R, 'Predicting risk of preterm delivery by second trimester measurement of maternal plasma corticotropin-releasing hormone and alpha-fetoprotein', American Journal of Obstetrics and Gynecology, (Sep);181(1) 207-215 (1999) [C1]
Citations Web of Science - 69
1999 Smith R, Wicking J, Bowman M, Belleoud A, Dubreuil G, Davies J, Madsen GM, 'Corticotropin-releasing hormone in chimpazee and gorilla pregnancies', Journal of clinical endocrinology and Metabolism, (Aug);84/8 2820-2825 (1999) [C1]
Citations Scopus - 57Web of Science - 47
Co-authors Gemma Madsen, Maria Bowman
1999 Keller PA, Bowman M, Dang KH, Garner JA, Leach SP, Smith R, McCluskey A, 'Pharmacophore development for corticotropin-releasing hormone: new insights into inhibitor activity', Journal of Medicinal Chemistry, 42, No. 13 2351-2357 (1999) [C1]
Citations Scopus - 36Web of Science - 37
Co-authors Adam Mccluskey, Maria Bowman
1999 Paul A, Bowman M, Kor HD, Garner J, Leach S, Smith R, McCluskey A, 'Pharmacophore development for coticotrophin-releasing hormone: new insights into inhibitor activity', Journal of Medicinal Chemistry, 42(13) 2351-2357 (1999) [C1]
1999 Smith R, 'The Timing of Birth', Scientific American, March 68-75 (1999) [C1]
Citations Scopus - 46Web of Science - 32
1999 Leung TN, Chung T, Madsen GM, McLean M, Chang AMZ, Smith R, 'Elevated mid-trimester maternal coritcotropin-releasing hormone levels in pregnancies destined to deliver preterm before 34 weeks', British Jounal of Obsetrics and Gynecology, (Oct);106 1041-1046 (1999) [C1]
Citations Scopus - 61Web of Science - 48
Co-authors Gemma Madsen
1999 McLean M, Smith R, 'Corticotropin-releasing hormone in human pregnancy and parturition', Trends in Endocrinology and metabolism, 10(5) 174-178 (1999) [C1]
Citations Scopus - 73Web of Science - 65
1998 Majzoub JA, Schulkin J, McGregor JA, Goland RS, Lockwood CJ, Smith R, Taggart MS, 'A central theory of preterm and term labor: putative role for corticotropin-releasing hormone', American Journal of Obstetrics and Gynecology, 180 232-241 (1998)
1998 Bisits AM, Madsen GM, McLean MT, Ocallaghan S, Smith R, Giles WB, 'CRH- a biomechnaical predictor of preterm delivery in a pilot randomised trial - of the treatment of preterm labour', American Journal of Obstetrics & Gynecology, 178 862-866 (1998) [C1]
Co-authors Gemma Madsen
1998 Bisits A, Madsen GM, McLean M, Ocallaghan S, Smith R, Giles W, 'Corticotropin-releasing hormone:a biochemical predictor of preterm delivery in a pilot randomised trial of the treatment of preterm labour', American Journal of Obstetrics and Gynaecology, 178(4) 862 (1998) [C1]
Citations Scopus - 30Web of Science - 27
Co-authors Gemma Madsen
1998 Chan EC, Falconer J, Madsen GM, Rice KC, Webster EL, Chrousos GP, Smith R, 'Corticotropin-releasing hormone type 1 receptor antagonist delays parturition in sheep', Endocrinology, 139(7) 3357-3360 (1998) [C1]
Citations Scopus - 57Web of Science - 47
Co-authors Gemma Madsen
1998 Smith R, Mesiano S, Chan EC, Brown S, Jaffe RB, 'Corticotropin-Releasing Hormone Directly and Preferentially Stimulates Dehydroepiandrosterone Sulphate Secretion by Human Fetal Adrenak cortical Cells', Journal of Clinical Endocrinology and Metabolism, 83/8 2916-2920 (1998) [C1]
Citations Scopus - 169Web of Science - 156
1998 Leitch IM, Boura ALA, Botti C, Read MA, Walters WAW, Smith R, 'Vasodilator Actions of Urocortin and Related Peptides in the Human Perfused Placenta In Vitro', Journal of Clinical Endocrinology anfd Metabolism, 83/12 4510-4513 (1998) [C1]
Citations Scopus - 69Web of Science - 61
1998 Smith R, 'Alterations in the hypothalamic pituitary adrenal axis during pregnancy and the placental clock that determines the length of parturition', Journal of Reproductive Immunology., 39 215-220 (1998) [C1]
1998 Jaffe RB, Mesiano S, Smith R, Coulter CL, Spencer SJ, Chakravorty A, 'The regulation and role of fetal adrenal development in human pregnancy', Endocrine Research, 24(3-4) 919-926 (1998) [C1]
Citations Scopus - 22Web of Science - 17
1997 Ni X, Chan EC, Fitter JT, Smith R, 'Nitric oxide inhibits corticotropin-releasing hormone exocytosis but not synthesis by cultured human trophoblasts', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 82 4171-4175 (1997)
DOI 10.1210/jc.82.12.4171
Citations Scopus - 32Web of Science - 26
Co-authors John Fitter
1997 Leitch IM, Roe CM, Walters WAW, Smith R, Boura ALA, 'Effect of the L-arginine nitric oxide pathway on human placental vascular tone and corticotropin-releasing hormone secretion', HYPERTENSION IN PREGNANCY, 16 367-378 (1997)
DOI 10.3109/10641959709031645
Citations Scopus - 2Web of Science - 2
1997 Bowman M, Robinson PJ, Smith R, 'Atrial natriuretic peptide, cyclic GMP analogues and modulation of guanylyl cyclase do not alter stimulated POMC peptide release from perifused rat or sheep corticotrophs', Journal of Neuroendocrinology, 9 929-936 (1997) [C1]
DOI 10.1046/j.1365-2826.1997.00665.x
Citations Scopus - 7Web of Science - 6
Co-authors Maria Bowman
1996 Roe CM, Leitch IM, Boura ALA, Smith R, 'Nitric oxide regulation of corticotropin-releasing hormone release from the human perfused placenta in vitro', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 81 763-769 (1996)
DOI 10.1210/jc.81.2.763
Citations Scopus - 22Web of Science - 26
1996 Clifton VL, Read MA, Boura ALA, Robinson PJ, Smith R, 'Adrenocorticotropin causes vasodilatation in the human fetal-placental circulation', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 81 1406-1410 (1996)
DOI 10.1210/jc.81.4.1406
Citations Scopus - 21Web of Science - 20
Co-authors Vicki Clifton
1996 Giles WB, McLean M, Davies JJ, Smith R, 'Abnormal umbilical artery Doppler waveforms and cord blood corticotropin-releasing hormone', OBSTETRICS AND GYNECOLOGY, 87 107-111 (1996)
DOI 10.1016/0029-7844(95)00338-X
Citations Scopus - 54Web of Science - 45
1996 Li H, Liu JP, Smith R, Robinson PJ, 'Identification of cGMP-dependent protein kinase and its specific substrates in the anterior pituitary', MOLECULAR AND CELLULAR ENDOCRINOLOGY, 122 159-171 (1996)
DOI 10.1016/0303-7207(96)03881-6
Citations Web of Science - 10
1995 CLIFTON VL, OWENS PC, ROBINSON PJ, SMITH R, 'IDENTIFICATION AND CHARACTERIZATION OF A CORTICOTROPIN-RELEASING HORMONE-RECEPTOR IN HUMAN PLACENTA', EUROPEAN JOURNAL OF ENDOCRINOLOGY, 133 591-597 (1995)
Citations Scopus - 35Web of Science - 34
Co-authors Vicki Clifton
1995 McLean M, Bisits A, Davies J, Woods R, Lowry P, Smith R, 'A placental clock controlling the length of human pregnancy', Nature Medicine, 1 460-463 (1995) [C1]
Citations Scopus - 618Web of Science - 549
1995 CLIFTON VL, READ MA, LEITCH IM, GILES WB, BOURA ALA, ROBINSON PJ, SMITH R, 'CORTICOTROPIN-RELEASING HORMONE-INDUCED VASODILATATION IN THE HUMAN FETAL-PLACENTAL CIRCULATION - INVOLVEMENT OF THE NITRIC OXIDE CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE-MEDIATED PATHWAY', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 80 2888-2893 (1995)
DOI 10.1210/jc.80.10.2888
Citations Scopus - 125Web of Science - 114
1995 MCLEAN M, SMITH R, 'CUSHINGS-SYNDROME - HOW SHOULD WE INVESTIGATE IN 1995', MEDICAL JOURNAL OF AUSTRALIA, 163 153-154 (1995)
Citations Scopus - 1
1995 HARTE JL, EIFERT GH, SMITH R, 'THE EFFECTS OF RUNNING AND MEDITATION ON BETA-ENDORPHIN, CORTICOTROPIN-RELEASING HORMONE AND CORTISOL IN PLASMA, AND ON MOOD', BIOLOGICAL PSYCHOLOGY, 40 251-265 (1995)
DOI 10.1016/0301-0511(95)05118-T
Citations Scopus - 55Web of Science - 43
1994 MCLEAN M, THOMPSON D, ZHANG HP, BRINSMEAD M, SMITH R, 'CORTICOTROPIN-RELEASING HORMONE AND BETA-ENDORPHIN IN LABOR', EUROPEAN JOURNAL OF ENDOCRINOLOGY, 131 167-172 (1994)
Citations Scopus - 51Web of Science - 45
1994 SUN K, SMITH R, ROBINSON PJ, 'BASAL AND KCL-STIMULATED CORTICOTROPIN-RELEASING HORMONE-RELEASE FROM HUMAN PLACENTAL SYNCYTIOTROPHOBLASTS IS INHIBITED BY SODIUM-NITROPRUSSIDE', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 79 519-524 (1994)
DOI 10.1210/jc.79.2.519
Citations Scopus - 36Web of Science - 38
1994 CLIFTON VL, READ MA, LEITCH IM, BOURA ALA, ROBINSON PJ, SMITH R, 'CORTICOTROPIN-RELEASING HORMONE-INDUCED VASODILATATION IN THE HUMAN FETAL-PLACENTAL CIRCULATION', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 79 666-669 (1994)
DOI 10.1210/jc.79.2.666
Citations Scopus - 95Web of Science - 90
1993 CHAN EC, SMITH R, LEWIN T, BRINSMEAD MW, ZHANG HP, CUBIS J, et al., 'PLASMA CORTICOTROPIN-RELEASING HORMONE, BETA-ENDORPHIN AND CORTISOL INTERRELATIONSHIPS DURING HUMAN-PREGNANCY', ACTA ENDOCRINOLOGICA, 128 339-344 (1993)
Citations Scopus - 80Web of Science - 71
Co-authors Terry Lewin
1993 SMITH R, CHAN EC, BOWMAN ME, HAREWOOD WJ, PHIPPARD AF, 'CORTICOTROPIN-RELEASING HORMONE IN BABOON PREGNANCY', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 76 1063-1068 (1993)
DOI 10.1210/jc.76.4.1063
Citations Scopus - 39Web of Science - 43
1993 POWELL KA, SMITH R, ROBINSON PJ, 'IMMUNOCYTOCHEMICAL LOCALIZATION OF DEPHOSPHIN, A NEURONAL PROTEIN-KINASE-C SUBSTRATE, IN THE RAT-BRAIN', JOURNAL OF NEUROCHEMISTRY, 61 S134-S134 (1993)
1993 McLean M, Walters WAW, Smith R, 'Prediction and early diagnosis of preterm labor: A critical review', Obstetrical and Gynecological Survey, 48 209-225 (1993)
Citations Scopus - 82
1992 CHAN EC, SMITH R, 'BETA-ENDORPHIN IMMUNOREACTIVITY DURING HUMAN-PREGNANCY', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 75 1453-1458 (1992)
DOI 10.1210/jc.75.6.1453
Citations Scopus - 22Web of Science - 20
1992 GUDE NM, BOURA ALA, KING RG, BRENNECKE SP, JAMAL OS, SMITH R, WALTERS WAW, 'EVIDENCE FOR INHIBITION BY ENDOTHELIUM-DERIVED RELAXING FACTOR OF THROMBOXANE-A2 RECEPTOR-MEDIATED VASOCONSTRICTION IN THE FETAL VESSELS OF THE HUMAN PERFUSED PLACENTA', PLACENTA, 13 597-605 (1992)
Citations Scopus - 29Web of Science - 27
1992 BOULTON TJC, SMITH R, SINGLE T, 'PSYCHOSOCIAL GROWTH FAILURE - A POSITIVE RESPONSE TO GROWTH-HORMONE AND PLACEBO', ACTA PAEDIATRICA, 81 322-325 (1992)
DOI 10.1111/j.1651-2227.1992.tb12235.x
Citations Scopus - 12Web of Science - 11
1991 MULLINS RJ, RUSSELL A, MCGRATH GJ, SMITH R, SUTHERLAND DC, 'BREAST-FEEDING ANAPHYLAXIS', LANCET, 338 1279-1280 (1991)
DOI 10.1016/0140-6736(91)92152-R
Citations Scopus - 12Web of Science - 6
1991 MADSEN G, CHAN EC, FALCONER J, HO KY, SMITH R, 'REVERSE HEMOLYTIC PLAQUE-ASSAY STUDY OF CORTICOTROPIN-RELEASING HORMONE AND ARGININE VASOPRESSIN INTERACTION IN OVINE CORTICOTROPES', JOURNAL OF NEUROENDOCRINOLOGY, 3 193-197 (1991)
DOI 10.1111/j.1365-2826.1991.tb00262.x
Citations Scopus - 3Web of Science - 5
1991 FALCONER J, DAVIES JJ, ZHANG HP, SMITH R, 'RELEASE OF INSULIN-LIKE GROWTH FACTOR-I BY THE SHEEP PLACENTA INVITRO', REPRODUCTION FERTILITY AND DEVELOPMENT, 3 379-384 (1991)
DOI 10.1071/RD9910379
Citations Scopus - 7Web of Science - 7
1991 DAVIES JJ, FALCONER J, ZHANG HP, CHAN EC, MCLEAN M, SMITH R, 'PERIFUSED OVINE PLACENTAL TISSUE SECRETES BETA-ENDORPHIN IMMUNOREACTIVITY', REPRODUCTION FERTILITY AND DEVELOPMENT, 3 397-404 (1991)
DOI 10.1071/RD9910397
Citations Scopus - 3Web of Science - 2
1990 SMITH R, CUBIS J, BRINSMEAD M, LEWIN T, SINGH B, OWENS P, et al., 'MOOD CHANGES, OBSTETRIC EXPERIENCE AND ALTERATIONS IN PLASMA-CORTISOL, BETA-ENDORPHIN AND CORTICOTROPIN RELEASING HORMONE DURING PREGNANCY AND THE PUERPERIUM', JOURNAL OF PSYCHOSOMATIC RESEARCH, 34 53-69 (1990)
DOI 10.1016/0022-3999(90)90008-R
Citations Scopus - 84Web of Science - 74
Co-authors Terry Lewin
1990 THOMSON M, CHAN EC, DAVIES J, FALCONER J, MADSEN G, GERAGHTY S, SMITH R, 'INTRACELLULAR MECHANISMS GOVERNING THE ACUTE PHASE OF BETA-ENDORPHIN SECRETION FROM THE CORTICOTROPE INVITRO', NEUROSCIENCE LETTERS, 110 343-348 (1990)
DOI 10.1016/0304-3940(90)90871-6
Citations Scopus - 6Web of Science - 5
1990 CHAN EC, BRINSMEAD MW, CHEN SE, NANRA R, SIMM B, MCLEAN M, SMITH R, 'URINARY CORTICOTROPIN-RELEASING HORMONE IMMUNOREACTIVITY IS ELEVATED DURING HUMAN-PREGNANCY', GYNECOLOGICAL ENDOCRINOLOGY, 4 233-244 (1990)
DOI 10.3109/09513599009024977
Citations Scopus - 7Web of Science - 8
1990 CHAN EC, THOMSON M, MADSEN G, BOETTCHER B, FALCONER J, SMITH R, 'LARGE MOLECULAR-WEIGHT IMMUNOREACTIVE CORTICOTROPIN-RELEASING HORMONE HAS BIOACTIVITY ON SUPERFUSED OVINE PITUITARY-CELLS', JOURNAL OF NEUROENDOCRINOLOGY, 2 95-101 (1990)
DOI 10.1111/j.1365-2826.1990.tb00399.x
Citations Scopus - 6Web of Science - 6
1990 THOMSON M, CHAN EC, FALCONER J, MADSEN G, GERAGHTY S, CURRYER N, et al., 'DESENSITIZATION OF SUPERFUSED ISOLATED OVINE ANTERIOR-PITUITARY-CELLS TO HUMAN CORTICOTROPIN-RELEASING FACTOR', JOURNAL OF NEUROENDOCRINOLOGY, 2 181-187 (1990)
DOI 10.1111/j.1365-2826.1990.tb00848.x
Citations Scopus - 15Web of Science - 15
1989 OWENS PC, OWENS JA, LOVELOCK M, CHAN EC, FALCONER J, ROBINSON JS, SMITH R, 'RESTRICTION OF PLACENTAL GROWTH IN SHEEP ENHANCES PLACENTAL METABOLISM OF FETAL BETA-ENDORPHIN-LIKE IMMUNOREACTIVITY', JOURNAL OF DEVELOPMENTAL PHYSIOLOGY, 11 63-71 (1989)
Citations Scopus - 3Web of Science - 2
1989 KUSNECOV AW, HUSBAND AJ, KING MG, SMITH R, 'MODULATION OF MITOGEN-INDUCED SPLEEN-CELL PROLIFERATION AND THE ANTIBODY-FORMING CELL RESPONSE BY BETA-ENDORPHIN INVIVO', PEPTIDES, 10 473-479 (1989)
DOI 10.1016/0196-9781(89)90061-2
Citations Scopus - 27Web of Science - 24
1988 LEVICK M, SAUNDERS N, SMITH R, LOVELOCK M, 'BETA-ENDORPHIN AND THE VENTILATORY RESPONSE TO HYPERCAPNIA IN HUMANS', AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 18 542-542 (1988)
1988 BOULTON J, SMITH R, HALL C, GLEESON M, GERAGHTY S, 'GROWTH-HORMONE SECRETION IN GROWTH FAILURE FROM EMOTIONAL DEPRIVATION AND DEPRESSION', AUSTRALIAN PAEDIATRIC JOURNAL, 24 77-78 (1988)
Co-authors Maree Gleeson
1988 CHAN EC, THOMSON M, MADSEN G, FALCONER J, SMITH R, 'DIFFERENTIAL PROCESSING OF CORTICOTROPHIN-RELEASING HORMONE BY THE HUMAN-PLACENTA AND HYPOTHALAMUS', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 153 1229-1235 (1988)
DOI 10.1016/S0006-291X(88)81359-7
Citations Scopus - 24Web of Science - 25
1988 OWENS PC, CHAN EC, LOVELOCK M, FALCONER J, SMITH R, 'IMMUNOREACTIVE METHIONINE-ENKEPHALIN IN CEREBROSPINAL-FLUID AND BLOOD-PLASMA DURING ACUTE STRESS IN CONSCIOUS SHEEP', ENDOCRINOLOGY, 122 311-318 (1988)
Citations Scopus - 7Web of Science - 9
1988 SMITH R, LOVELOCK M, OWENS PC, CHAN EC, FALCONER J, 'THE EFFECT OF REPETITIVE HEMORRHAGE ON PLASMA-CORTISOL, BETA-ENDORPHIN AND N-TERMINAL PRO-OPIOMELANOCORTIN IN CONSCIOUS SHEEP', HORMONE AND METABOLIC RESEARCH, 20 612-615 (1988)
DOI 10.1055/s-2007-1010898
Citations Scopus - 7Web of Science - 8
1988 FALCONER J, CHAN EC, MADSEN G, THOMSON M, DAVIES J, SMITH R, 'SECRETION OF BETA-ENDORPHIN INTO THE MATERNAL CIRCULATION BY UTEROPLACENTAL TISSUES IN RESPONSE TO HYPOGLYCEMIC STRESS', JOURNAL OF ENDOCRINOLOGY, 118 R5-R8 (1988)
DOI 10.1677/joe.0.118R005
Citations Scopus - 20Web of Science - 15
1988 THOMSON M, CHAN EC, FALCONER J, MADSEN G, SMITH R, 'SECRETION OF CORTICOTROPIN-RELEASING HORMONE BY SUPERFUSED HUMAN PLACENTAL FRAGMENTS', GYNECOLOGICAL ENDOCRINOLOGY, 2 87-100 (1988)
DOI 10.3109/09513598809023617
Citations Scopus - 25Web of Science - 25
1987 Ross RJM, Borges F, Grossman A, Smith R, Ngahfoong L, Rees LH, et al., 'Growth hormone pretreatment in man blocks the response to growth hormone-releasing hormone; evidence for a direct effect of growth hormone.', Clinical Endocrinology, 26 117-123 (1987)
1987 SMITH R, OWENS PC, BRINSMEAD MW, SINGH B, HALL C, 'THE NONSUPPRESSIBILITY OF PLASMA-CORTISOL PERSISTS AFTER PREGNANCY', HORMONE AND METABOLIC RESEARCH, 19 41-42 (1987)
DOI 10.1055/s-2007-1011733
Citations Scopus - 14Web of Science - 16
1987 OWENS PC, SMITH R, BRINSMEAD MW, HALL C, ROWLEY M, HURT D, et al., 'POSTNATAL DISAPPEARANCE OF THE PREGNANCY-ASSOCIATED REDUCED SENSITIVITY OF PLASMA-CORTISOL TO FEEDBACK INHIBITION', LIFE SCIENCES, 41 1745-1750 (1987)
DOI 10.1016/0024-3205(87)90603-5
Citations Scopus - 39Web of Science - 39
Co-authors Terry Lewin
1987 OWENS PC, SMITH R, 'OPIOID-PEPTIDES IN BLOOD AND CEREBROSPINAL-FLUID DURING ACUTE STRESS', BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1 415-437 (1987)
Citations Web of Science - 32
1986 SMITH R, OWENS PC, LOVELOCK M, CHAN EC, FALCONER J, 'ACUTE HEMORRHAGIC STRESS IN CONSCIOUS SHEEP ELEVATES IMMUNOREACTIVE BETA-ENDORPHIN IN PLASMA BUT NOT IN CEREBROSPINAL-FLUID', ENDOCRINOLOGY, 118 2572-2576 (1986)
Citations Scopus - 23Web of Science - 33
1986 SINGH B, GILHOTRA M, SMITH R, BRINSMEAD M, LEWIN T, HALL C, 'POSTPARTUM PSYCHOSES AND THE DEXAMETHASONE SUPPRESSION TEST', JOURNAL OF AFFECTIVE DISORDERS, 11 173-177 (1986)
DOI 10.1016/0165-0327(86)90026-1
Citations Scopus - 14Web of Science - 13
Co-authors Terry Lewin
1985 BRINSMEAD M, SMITH R, SINGH B, LEWIN T, OWENS P, 'PERIPARTUM CONCENTRATIONS OF BETA-ENDORPHIN AND CORTISOL AND MATERNAL MOOD STATES', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 25 194-197 (1985)
DOI 10.1111/j.1479-828X.1985.tb00642.x
Citations Scopus - 38Web of Science - 28
Co-authors Terry Lewin
1985 FALCONER J, OWENS PC, SMITH R, 'CANNULATION OF THE CISTERNA MAGNA IN SHEEP - A METHOD FOR CHRONIC STUDIES OF CEREBROSPINAL-FLUID', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 63 157-162 (1985)
DOI 10.1038/icb.1985.17
Citations Scopus - 4Web of Science - 5
1985 OWENS P, LOVELOCK M, CHAN EC, FALCONER J, LING N, SMITH R, 'SECRETION OF N-TERMINAL PRO-OPIOMELANOCORTIN-DERIVED PEPTIDES IN RESPONSE TO ACUTE HEMORRHAGIC STRESS IN CONSCIOUS SHEEP', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 133 648-653 (1985)
DOI 10.1016/0006-291X(85)90954-4
Citations Scopus - 3Web of Science - 6
1985 SMITH R, BESSER GM, REES LH, 'THE EFFECT OF SURGERY ON PLASMA BETA-ENDORPHIN AND METHIONINE-ENKEPHALIN', NEUROSCIENCE LETTERS, 55 17-21 (1985)
DOI 10.1016/0304-3940(85)90305-2
Citations Scopus - 20Web of Science - 25
1985 SMITH R, GROSSMAN A, BOYCE MJ, BESSER GM, REES LH, 'EFFECT OF HISTAMINE INFUSION ON CIRCULATING METHIONINE-ENKEPHALIN AND CATECHOLAMINE CONCENTRATIONS', NEUROSCIENCE LETTERS, 55 289-292 (1985)
DOI 10.1016/0304-3940(85)90450-1
Citations Scopus - 6Web of Science - 11
1985 SMITH R, GROSSMAN A, GIMSON AES, BESSER GM, REES LH, 'EFFECT OF LIVER AND RENAL DYSFUNCTION ON CIRCULATING METHIONINE-ENKEPHALIN IMMUNOREACTIVITY', NEUROSCIENCE LETTERS, 60 301-305 (1985)
DOI 10.1016/0304-3940(85)90594-4
Citations Scopus - 3Web of Science - 5
1984 OWENS PC, SMITH R, GREEN D, FALCONER L, 'EFFECT OF HYPOGLYCEMIC STRESS ON PLASMA AND CEREBROSPINAL-FLUID IMMUNOREACTIVE BETA-ENDORPHIN IN CONSCIOUS SHEEP', NEUROSCIENCE LETTERS, 49 1-6 (1984)
DOI 10.1016/0304-3940(84)90126-5
Citations Scopus - 12Web of Science - 21
1984 OWENS PC, SMITH R, OWENS JA, FALCONER J, BRINSMEAD MW, ROBINSON JS, 'FETAL PRODUCTION AND PLACENTAL CONSUMPTION OF PLASMA BETA-ENDORPHIN', JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 20 1430-1430 (1984)
DOI 10.1016/0022-4731(84)90547-8
Citations Web of Science - 1
1981 Smith R, Smith R, Grossman A, Gaillard R, Clement-Jones V, Ratter S, et al., 'Studies on circulating met-enkephalin and beta-endorphin: normal subjects and patients with renal and adrenal disease.', Clinical Endocrinology, 15 291-300 (1981)
1981 Smith R, Grossman A, Gaillard R, Clement-Jones V, Ratter S, Mallinson J, et al., 'Studies on circulating met-enkephalin and ß-endorphin: normal subjects and patients with renal and adrenal disease.', Clinical Endocrinology, 15 291-300 (1981)
Show 241 more journal articles

Conference (165 outputs)

Year Citation Altmetrics Link
2016 Mah B, Weatherall L, Burrows J, Blackwell C, Wadhwa P, Lumbers E, et al., 'Psychological Distress in Pregnant Australian Indigenous Women Residing in Rural and Remote New South Wales of Australia', REPRODUCTIVE SCIENCES (2016)
Co-authors Julie Burrows, Kym Rae
2016 Mohapatra L, Senior A, Hure A, Rae KM, Simpson S, Raubenheimer D, et al., 'Links between dietary amino acids in pregnancy, gestational length and birth weight', Developmental Origins of Health and Disease Conference (2016)
Co-authors Clare Collins, Kym Rae, Alexis Hure
2015 Maiti K, Sultana Z, Aitken J, Smith R, 'THE HUMAN PLACENTA AT 41 WEEKS OF GESTATION SHOWS EVIDENCE OF AGING WITH SHORTENED TELOMERES, DNA OXIDATION AND CHANGES IN IGFR2, AUTOPHAGY AND MTOR', PLACENTA (2015) [E3]
Co-authors John Aitken
2015 Pringle K, Grimson S, Wang Y, Weatherall L, Smith R, Rae KM, et al., 'Cytokine Gene Polymorphisms in an Indigenous Australian Pregnancy Population', Reproductive Sciences (2015) [E3]
Co-authors Kirsty Pringle, Kym Rae, Caroline Blackwell
2015 Wark P, Tolosa J, Parsons K, Hansbro P, Smith R, 'THE PLACENTAL PROTEIN SYNCYTIN-1 IMPAIRS ANTIVIRAL RESPONSES AND EXAGGERATES INFLAMMATORY RESPONSES TO INFLUENZA', RESPIROLOGY (2015) [E3]
Co-authors Peter Wark, Philip Hansbro
2015 Paul J, Hua S, Smith R, 'A Targeted Drug Delivery System for the Uterus', REPRODUCTIVE SCIENCES (2015) [E3]
Citations Web of Science - 1
Co-authors Jonathan Paul, Susan Hua
2015 Stirrat L, O'Reilly J, Riley S, Howie A, Bowman M, Smith R, et al., 'Hypothalamic Pituitary Adrenal Axis Hormones Are Reduced in Obese Pregnancy', REPRODUCTIVE SCIENCES (2015) [E3]
Co-authors Maria Bowman
2015 Maiti K, Aitken J, Smith R, 'The Human Placenta at 41 Weeks of Gestation Shows Evidence of Aging With Shortened Telomeres, DNA Oxidation and Changes in IGFR2, Autophagy and the mTOR', REPRODUCTIVE SCIENCES (2015) [E3]
Co-authors John Aitken
2015 Rae KM, Weatherall L, Collins C, Smith R, Lumbers ER, Pringle K, 'Maternal obesity negatively impacts on fetal maternal health and birth outcomes in an Indigenous Australian cohort', Journal of Developmental Origins of Health and Disease (2015) [E3]
Co-authors Kym Rae, Clare Collins, Kirsty Pringle
2015 Weatherall L, Smith R, Collins C, Rae KM, Lumbers ER, Pringle K, 'Risk factors for development of future chronic disease from an Indigenous Australian cohort', Journal of Developmental Origins of Health and Disease (2015) [E3]
Co-authors Clare Collins, Kym Rae
2015 Smith R, 'AGING AND THE PLACENTA', PLACENTA (2015) [E3]
2015 Rollo M, Ashman A, Brown L, Rae KM, Weatherall L, Skinner G, Smith R, 'A brief tool for assessing diet quality and selected nutrient intakes from image-based dietary records: Design and preliminary results from use in pregnant women' (2015) [E3]
Co-authors Kym Rae, Leanne Brown, Megan Rollo, Geoff Skinner
2015 Sultana Z, Maiti K, Smith R, 'USE OF AN IN VITRO HUMAN PLACENTAL EXPLANT CULTURE MODEL TO INTERROGATE THE EFFECTS OF STARVATION ON PLACENTAL FUNCTION', PLACENTA (2015) [E3]
2015 Rae KM, Pringle K, Sykes S, Weatherall L, Clausen D, Smith R, et al., 'Factors affecting blood pressure and renal health in Australian Indigenous Women', Reproductive Sciences (2015) [E3]
Co-authors Kirsty Pringle, Caroline Blackwell, Kym Rae
2015 Pringle K, Sykes S, Weatherall L, Clausen D, Smith R, Rae KM, Lumbers E, 'Interrelationships between circulating and urinary components of the renin-angiotensin system in Indigenous pregnant women', Reproductive Sciences (2015) [E3]
Co-authors Kym Rae, Kirsty Pringle
2015 Smith R, Rae K, Lumbers E, Kandasamy Y, Pringle K, Weatherall L, 'Preterm birth and low birthweight in the Aboriginal and Torres Strait Islander Population', BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2015) [E3]
Co-authors Kym Rae, Kirsty Pringle
2015 Rowe C, McGrath S, Smith R, 'Response of TSH-Secreting Pituitary Tumours to Somatostatin Analogues in Five Patients' (2015)
DOI 10.1210/endo-meetings.2015.BCHVD.11.SAT-256
2015 Smith R, 'Aging at the Start of Life.', Society of Reproductive Biology/Endocrine Society of Australia Annual Scientific Meeting. Oral Abstracts (2015) [E3]
2015 Pringle KG, Weatherall L, Collins CE, Smith R, Rae K, 'Maternal Obesity negatively impacts on fetal kidney development, maternal health and birth outcomes in an Indigenous Australian cohort', Society of Reproductive Biology/Endocrine Society of Australia Annual Scientific Meeting. Oral Abstracts (2015) [E3]
Co-authors Kym Rae, Kirsty Pringle, Clare Collins
2015 Lumbers ER, Sykes SD, Weatherall L, Clausen D, Smith R, Rae K, Pringle KG, 'INTERRELATIONSHIPS BETWEEN CIRCULATING AND URINARY COMPONENTS OF THE RENIN-ANGIOTENSIN SYSTEM IN INDIGENOUS PREGNANT WOMEN', HYPERTENSION (2015) [O1]
Co-authors Kym Rae, Kirsty Pringle
2015 Chan E-C, Smith R, 'RNA-Binding Protein ELAV1 imRNA Increases With Labor in the Human Myometrium.', REPRODUCTIVE SCIENCES (2015) [E3]
2014 Pringle K, Rae KM, Weatherall L, Hall S, Burns C, Smith R, et al., 'Effects of cigarette smoke and maternal inflammation in pregnancy on birth weight and gestational age at delivery in an Indigenous Australian population', Proceedings of the 57th ESA and 45th SRB Annual Conference (2014) [E3]
Co-authors Kym Rae, Caroline Blackwell, Sharron Hall, Kirsty Pringle
2014 Rae KM, Pringle KG, Sykes SD, Weatherall L, Clausen D, Smith R, et al., 'Factors affecting blood pressure and renal health in young Indigenous pregnant women', State of the Heart 2014 Congress (2014) [E3]
Co-authors Caroline Blackwell, Kym Rae, Kirsty Pringle
2014 Pringle KG, Sykes S, Diehm C, Weatherall L, Galal M, Clausen D, et al., 'The intrarenal renin angiotensin system in pregnancy and its potential in predicting renal dysfunction and fetal kidney development in Indigenous and non-Indigenous Australian women', Abstracts of the 18th Congress of the Perinatal Society of Australia and New Zealand (PSANZ) (2014) [E3]
DOI 10.1111/jpc.12528/abstract
Co-authors Kym Rae, Kirsty Pringle
2014 Lumbers ER, Pringle KG, Sykes SD, Weatherall L, Clausen DC, Rae K, Smith R, 'THE INTRARENAL RENIN-ANGIOTENSIN SYSTEM (RAS) IN HUMAN PREGNANCY', HYPERTENSION (2014) [E3]
Co-authors Kirsty Pringle, Kym Rae
2014 Wark PPW, Tolosa JMJT, Parsons K, Smith R, 'The placental derived protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza', Cytokine (2014) [E3]
DOI 10.1016/j.cyto.2014.07.154
Co-authors Peter Wark
2014 Pan X, Smith R, Scott RJ, Fitter J, Zakar T, 'Corticotropin Releasing Hormone (CRH) Expression Is Controlled by DNA Methylation in the Trophoblast', REPRODUCTIVE SCIENCES (2014) [E3]
Citations Web of Science - 1
Co-authors John Fitter, Rodney Scott
2014 Tolosa JM, Parsons K, Wark P, Smith R, 'HOW THE PLACENTA MAKES PREGNANT WOMEN VULNERABLE TO INFLUENZA (FLU)', PLACENTA (2014) [E3]
Co-authors Peter Wark
2014 Ashman A, Weatherall L, Brown LJ, Collins C, Naden M, Rae K, et al., 'Infant feeding practices in an Aboriginal cohort of pregnancy and infancy - the Gomeroi gaaynggal study', Aboriginal Health Conference 2014 (2014) [E3]
Co-authors Kym Rae, Megan Rollo, Leanne Brown, Clare Collins
2014 Stirrat L, O'Reilly J, Riley S, Howie A, Smith R, Walker B, et al., 'PPO.21 Altered maternal hypothalamic-pituitary-adrenal axis activity in obese pregnancy: a potential mechanism underlying macrosomia and prolonged pregnancy.', Arch Dis Child Fetal Neonatal Ed (2014) [E3]
DOI 10.1136/archdischild-2014-306576.461
2013 Pringle KG, Sykes SD, Weatherall L, Clausen D, Smith R, Rae KM, Lumbers ER, 'Novel Urinary Biomarkers for Predicting Pregnancy Outcome in Indigenous and Non- Indigenous Australian Women', Published proceedings of the Fetal and Neonatal Workshop (2013) [E3]
Co-authors Kirsty Pringle, Kym Rae
2013 Pringle KG, Sykes SD, Weatherall L, Galal, Clausen D, Smith R, et al., 'The intrarenal renin angiotensin system in pregnancy and its potential in predicting pregnancy outcome and renal dysfunction in Indigenous and non-Indigenous Australian women', Published proceedings of the Society for Reproductive Biology (2013) [E3]
Co-authors Kym Rae
2013 Pringle K, Sykes SD, Weatherall L, Clausen D, Smith R, Rae KM, Lumbers ER, 'Novel renal biomarkers for predicting pregnancy outcome', Published proceedings of the Symposium on Vasoactive Peptides (2013) [E3]
Co-authors Kym Rae, Kirsty Pringle
2013 Rae KM, Weatherall L, Clausen D, Maxwell C, Bowman M, Milgate P, et al., 'Gomeroi gaaynggal: Empowerment of Aboriginal communities to understand health implications of research in pregnancy', Proceedings of th 12th National Rural Health Conference (2013) [E1]
Co-authors Kym Rae, Maria Bowman, Sharron Hall
2013 Rae KM, Lumbers ER, Pringle KG, Sykes SD, Weatherall L, Clausen D, Smith R, 'Measurement of the activity of the circulating and intrarenal renin-angiotensin system (iRAS) in pregnant and non-pregnant subjects PP036', Pregnancy Hypertension (2013)
Co-authors Kirsty Pringle, Kym Rae
2013 Pringle, Lumbers, Sykes, Weatherall, Clausen D, Rae KM, Smith, 'The intrarenal renin angiotensin system and pregnancy outcome.', Pregnancy Hypertension: an International Journal of Women's Cardiovascular Health (2013) [E3]
DOI 10.1016/j.preghy.2013.04.063
Co-authors Kym Rae, Kirsty Pringle
2013 Lumbers, Pringle, Sykes, Weatherall, Clausen D, Rae KM, Smith, 'Measurement of the activity of the circulating and intrarenal renin-angiotensin system (iRAS) in pregnant and non-pregnant subjects.', Pregnancy Hypertension: an International Journal of Women¿s Cardiovascular Health. (2013) [E3]
DOI 10.1016/j.preghy.2013.04.053
Co-authors Kirsty Pringle, Kym Rae
2012 Chai S, Fitter JT, Smith R, Madsen GM, 'DNA methylation of progesterone receptor isoforms in term human myometrium', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012 (2012) [E3]
Co-authors Gemma Madsen, John Fitter
2012 Maiti K, Gravina FS, Bowman M, Aitken RJ, Smith R, 'The ageing placenta and still birth', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012 (2012) [E3]
Co-authors Maria Bowman, John Aitken
2012 Pan X, Nicholson RC, Scott R, Fitter JT, Smith R, Zakar T, 'DNA methylation associated with induction of CRH gene expression in trophoblast cells', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012 (2012) [E3]
Co-authors John Fitter, Rodney Scott
2012 Smith R, 'International Conference of Physiological Sciences 2012', International Conference of Physiological Sciences 2012. Program (2012) [E3]
2012 Weatherall LJ, Rae KM, Naden ML, Smith R, 'Research skills build healthy Aboriginal communities', International Indigenous Development Research Conference. Keynote Speakers: Biographies and Abstracts (2012) [E3]
Co-authors Kym Rae
2012 Parkington HC, Paul JW, Tonta MA, Chan EC, Sheehan PJ, Brennecke SP, et al., 'Human labour is associated with decreased myometrial ether-a-go-go related gene (hERG) potassium channels that modulate contractility', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society (2012) [E3]
Co-authors Jonathan Paul
2012 Rae KM, Weatherall L, Clausen D, Maxwell C, Bowman M, Milgate P, et al., 'The role of maternal renal health in an Australian Aboriginal population in fetal growth and renal development' (2012)
Co-authors Kym Rae, Sharron Hall, Maria Bowman
2012 Kandasamy Y, Smith R, Wright IM, 'The relationship between birthweight and retinal microvasculature in term infants', Journal of Paediatrics and Child Health (2012) [E3]
Co-authors Ian Wright
2012 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Smith R, Collins CE, 'Foetal abdominal fat area is predicted by the protein-to-carbohydrate ratio of maternal diet during pregnancy', Nutrition & Dietetics: Special Issue: Dietitians Association of Australia 16th International Congress of Dietetics (2012) [E3]
Co-authors Clare Collins, Alexis Hure, Lesley Wicks
2012 Martin JE, Hure AJ, MacDonald-Wicks LK, Smith R, Collins CE, 'Bouncing back to your pre-baby body: A RCT to reduce postpartum weight gain', Nutrition & Dietetics: Special Issue: Dietitians Association of Australia 16th International Congress of Dietetics (2012) [E3]
Co-authors Clare Collins, Alexis Hure, Lesley Wicks
2012 Smith R, 'What controls labour in humans?', Endocrine Abstracts (2012) [E3]
2012 Smith R, 'Regulation of CRF in reproduction', 59th Annual Meeting of the Society for Gynecologic Investigation. ¿¿¿Improving Women¿¿¿s Health through Personalized Medicine¿¿¿ (2012) [E3]
2011 Hure AJ, Collins CE, Giles WB, Paul JW, Smith R, 'A large but lean fetal phenotype is associated with greater maternal weight gain during pregnancy', Obesity Research & Clinical Practice (2011) [E3]
Co-authors Jonathan Paul, Alexis Hure, Clare Collins
2011 Chai SY, Smith R, Zakar T, Mitchell CM, Madsen GM, 'Term myometrium is characterized by increased activating epigenetic marks on the progesterone receptor A promoter', Reproductive Sciences (2011) [E3]
Co-authors Gemma Madsen
2011 Paul JW, Maiti K, Read MA, Hure AJ, Smith JI, Chan EC, Smith R, 'Studying laboring myometrium misses phosphorylation changes associated with contraction', Reproductive Sciences (2011) [E3]
Co-authors Jonathan Paul, Alexis Hure
2011 Hure AJ, Collins CE, Martin JE, Smith R, 'Breastfeeding and metabolic risk reduction at the time of lactation: The Women and Their Children's Health (WATCH) Cohort', Journal of Developmental Origins of Health and Disease (2011) [E3]
Co-authors Clare Collins, Alexis Hure
2011 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Smith R, Collins CE, 'Energy and macronutrient intakes during pregnancy over the last 50 years', 2011 Annual Meeting of the International Society for Behavioral Nutrition and Physical Activity (ISBNPA) eProceedings (2011) [E3]
Co-authors Alexis Hure, Lesley Wicks, Clare Collins
2011 Milgate P, Hall S, Carlin A, Boyd J, Bowman M, Rae KM, et al., 'The Birra-li Research Project: Pathways to better kidney health in the future', Proceedings of the 3rd Coalition for Research to Improve Aboriginal Health (CRIAH)Aboriginal Health Research conference (2011)
Co-authors Sharron Hall, Kym Rae, Maria Bowman
2011 Rae KM, Weatherall L, Hall S, Milgate P, Boyd J, Bowman M, et al., 'Tackling pregnancy outcomes ¿ the Gomeroi gaaynggal program' (2011)
Co-authors Sharron Hall, Kym Rae, Maria Bowman
2011 Tsai MH, Vears D, Sadleir L, Berkovic SF, Smith R, Scheffer IE, 'Clinical genetic studies in benign childhood epilepsy with centrotemporal spikes (BECTS)', Epilepsia (2011) [E3]
2011 Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity (2011) [E3]
Co-authors Philip Hansbro, Deborah Hodgson, Jay Horvat, Linkooi Ong
2011 Weatherall LJ, Rae KM, Milgate P, Hall ST, Carlin A, Boyd J, et al., 'A place of connections: The Gomeroi Gaaynggal Centre', Proceedings of the 3rd Coalition for Research to Improve Aboriginal Health (CRIAH) Aboriginal Health Research Conference (2011) [E3]
Co-authors Kym Rae, Maria Bowman, Sharron Hall
2011 Martin JE, Hure AJ, MacDonald-Wicks LK, Smith R, Smith JI, Collins CE, 'Pre-pregnancy BMI and pregnancy weight gain predict post-partum weight retention', Nutrition and Dietetics: Dietitians Association of Australia 29th National Conference Oral Program (2011) [E3]
Co-authors Clare Collins, Alexis Hure, Lesley Wicks
2010 Martin J, Hure AJ, MacDonald-Wicks LK, Smith R, Collins CE, 'Relationship between pregnancy weight status and breastfeeding patterns', Obesity Research and Clinical Practice (2010) [E3]
Co-authors Alexis Hure, Lesley Wicks, Clare Collins
2010 Hodyl NA, Smith R, Bisits AM, Gibson PG, Clifton VL, 'The effect of inhaled corticosteroids on maternal and fetal systemic function and placental activity in women with asthma', Reproductive Sciences (2010) [E3]
DOI 10.1177/193371912010173s003
Co-authors Peter Gibson, Vicki Clifton
2010 Maiti K, Paul JW, Read MA, Chan EC, Smith R, 'Human labor Is associated with internalization and oligomerization of the membrane estrogen receptor, GPR30', Reproductive Sciences (2010) [E3]
Co-authors Jonathan Paul
2010 Chan EC, Smith R, 'Differential expression of MicroRNA with labour in the human myometrium', The Endocrine Society of Australia Annual Scientific Meeting Meeting Proceedings and Abstract Book (2010) [E3]
2010 Maiti K, Paul JW, Chan EC, Smith R, 'GPR30, the novel membrane estrogen receptor, stimulates contractility of myometrium by increasing expression of h-caldesmon', The Endocrine Society of Australia Annual Scientific Meeting Meeting Proceedings and Abstract Book (2010) [E3]
Co-authors Jonathan Paul
2010 Paul JW, Maiti K, Read MA, Smith R, 'Caldesmon phosphorylation and phasic regulation of ERK 1/2 during contractions in human myometrium', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book (2010) [E3]
Co-authors Jonathan Paul
2010 Tolosa Gonzalez JM, Schjenken JE, Clifton VL, Smith R, 'A new function for the fusogenic endogenous retroviral envelope protein syncytin-1: assessment of its immunosuppressive properties', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book (2010) [E3]
Co-authors Vicki Clifton
2010 Chai S, Smith R, Madsen GM, 'Epigenetic regulation of progesterone receptor isoform expression in term human myometrium', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book (2010) [E3]
Co-authors Gemma Madsen
2010 Tolosa Gonzalez JM, Schjenken JE, Clifton VL, Smith R, 'The retroviral envelope protein syncytin-1 is immunosuppressive and has hijacked the exosomal pathway in the human placenta', Placenta (2010) [E3]
Citations Web of Science - 1
Co-authors Vicki Clifton
2010 Smith R, 'CRH & the onset of labor', ENDO 2010: The 92nd Annual Scientific Meeting and Expo Abstracts (2010) [E3]
2010 Schjenken JE, Tolosa Gonzalez JM, Clifton VL, Smith R, 'The endogenous retroviral envelope protein syncytin-1 inhibits the release of TNF alpha and IFN gamma in human blood cells', Journal of Reproductive Immunology (2010) [E3]
Co-authors Vicki Clifton
2010 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Patterson AJ, Smith R, Collins CE, 'Dietary intakes of Australian women prior to conception', Nutrition & Dietetics (2010) [E3]
Co-authors Alexis Hure, Lesley Wicks, Clare Collins, Amanda Patterson
2010 Hure AJ, Wright IM, Smith R, Collins CE, 'Evidence-based best-practice guidelines for nutritional supplementation in pregnancy', Nutrition & Dietetics (2010) [E3]
Co-authors Clare Collins, Ian Wright, Alexis Hure
2010 Fletcher K, Hure AJ, Collins CE, Smith R, 'Infant feeding patterns within the Watch Study', Nutrition & Dietetics (2010) [E3]
Co-authors Clare Collins, Alexis Hure
2010 Chen Y, Allars MJ, Abou-Seif C, Smith R, Nicholson RC, 'Differential Effects of cAMP and CRH in Cell Viability and Cell Fusion of Cytotrophoblastic Cells', Reproduction, Fertility and Development (2010) [E3]
2009 Hure AJ, Collins CE, Smith R, 'Maternal pregnancy folate predicts homocysteine in the six month old infant', Reproductive Sciences (2009) [E3]
DOI 10.1177/193371912009163s167
Co-authors Alexis Hure, Clare Collins
2009 Hure AJ, Collins CE, Smith R, 'Maternal weight change in pregnancy predicts fetal size but not adiposity', Reproductive Sciences (2009) [E3]
DOI 10.1177/193371912009163s167
Co-authors Clare Collins, Alexis Hure
2009 Maiti K, Paul JW, Read MA, Chan EC, Smith R, 'Demonstration that activation of the cell surface estrogen receptor GPR30 causes phosphorylation of HSP27 and MAPK p42/44 in term human myometrial tissue and explants', Reproductive Sciences (2009) [E3]
Co-authors Jonathan Paul
2009 Schjenken JE, Tolosa Gonzalez JM, Clifton VL, Smith R, 'Corticotrophin releasing hormone modulates the production of immunosuppressive factors FasL, Syncytin and Exosomes by the human placenta', Reproductive Sciences (2009) [E3]
Co-authors Vicki Clifton
2009 Hure AJ, Collins CE, Smith R, 'Vitamin B12, folate and homocysteine in the six month old infant', Journal of Developmental Origins of Health and Disease (2009) [E3]
Co-authors Clare Collins, Alexis Hure
2009 Hure AJ, Wright IM, Smith R, Collins CE, 'Nutrient supplementation in pregnancy: Development of evidence-based best-practice guidelines', Journal of Developmental Origins of Health and Disease (2009) [E3]
Co-authors Ian Wright, Alexis Hure, Clare Collins
2009 Paul JW, Read MA, Smith R, 'Phosphorylation events associated with myometrial awakening and the development of contractile force in humans', Reproductive Sciences (2009) [E3]
Co-authors Jonathan Paul
2009 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Patterson AJ, Smith R, Collins CE, 'The food choices of Australian women during pregnancy', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Lesley Wicks, Alexis Hure, Amanda Patterson, Clare Collins
2009 Gresham E, Hure AJ, Smith R, Collins CE, 'Maternal macronutrient and micronutrient profiles in pregnancy and postpartum', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Clare Collins, Alexis Hure
2009 Clarke NF, Monnier N, Smith R, Kornberg AJ, Farrell MA, Waddell L, et al., 'RYR1 is a common cause of congenital fibre type disproportion with ptosis, ophthalmoplegia, scoliosis and pronounced axial muscle weakness', Neuromuscular Disorders (2009) [E3]
2009 Hure AJ, Wright IM, Smith R, Collins CE, 'Nutrient supplementation in pregnancy: Development of evidence-based best-practice guidelines', Journal of Paediatrics and Child Health (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01475.x
Co-authors Alexis Hure, Ian Wright, Clare Collins
2009 Knox M, Smith R, Engel T, Wright IM, 'Transfers into a regional perinatal centre: Can we do better?', Journal of Paediatrics and Child Health (2009) [E3]
DOI 10.1111/j.1440-1754.2009.01475.x
Co-authors Ian Wright
2009 Fernando I, Athauda RI, Cohen M, Henskens FA, Smith R, 'Towards data-oriented clinical information systems and data mining in psychiatry: Can they beat clinical trials?', Australian and New Zealand Journal of Psychiatry (2009) [E3]
DOI 10.1080/00048670902940075
Co-authors Frans Henskens, Rukshan Athauda
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor, mineralocorticoid receptor and corticotrophin releasing hormone mRNA abundance', Proceedings of the Australian Neuroscience Society (2008) [E3]
Co-authors Olivia Wynne, Jay Horvat, Philip Hansbro, Vicki Clifton, Deborah Hodgson
2008 Hure AJ, Collins CE, Smith R, 'Maternal and infant vitamin B12, folate and homocysteine in pregnancy and postpartum', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Alexis Hure, Clare Collins
2008 Hure AJ, Giles WB, Smith R, Collins CE, 'Maternal weight change in pregnancy predicts fetal size but not adiposity', Proceedings of the Australian Health and Medical Research Congress 2008 (2008) [E3]
Co-authors Clare Collins, Alexis Hure
2008 Schjenken JE, Tolosa Gonzalez JM, Clifton V, Tuch B, Smith R, 'Lessons from pregnancy that may help in transplantation', Transplantation (2008) [E3]
2008 Smith R, 'Predicting the future during pregnancy', Reproductive Sciences (2008) [E3]
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor and mineralocorticoid receptor abundance', 15th Annual Meeting of the Psychoneuroimmunology Research Society: Program (2008) [E3]
Co-authors Deborah Hodgson, Vicki Clifton, Philip Hansbro, Olivia Wynne, Jay Horvat
2008 Abou-Seif C, Shipman KL, Allars MJ, Smith R, Nicholson RC, 'Tissue specific epigenetic regulation of CRH gene expression', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book (2008) [E3]
2008 Maiti K, Paul JW, Read MA, Chan EC, Smith R, 'Presence of the novel membrane estrogen receptor G-Protein coupled receptor 30 (GPR30) a membrane estrogen receptor in human pregnant myometrium and its biochemical characterization', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book (2008) [E3]
Co-authors Jonathan Paul
2008 Osei-Kumah A, Wark PA, Smith R, Ammit A, Clifton VL, 'A model of pregnancy induced changes in asthma', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book (2008) [E3]
Co-authors Vicki Clifton, Peter Wark
2008 Paul JW, Read MA, Chan EC, Smith R, 'Phospho-proteomic determination of contraction associated proteins in the human uterus', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book (2008) [E3]
Co-authors Jonathan Paul
2008 Smith R, Smith JI, Shen X, Bisits AM, Engel PJ, Giles WB, et al., 'The onset of human labor is associated with a fall in the ration of progesterone to estrogens and an increase in the estriol to estradiol ratio', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book (2008) [E3]
Co-authors Maria Bowman, Patrick Mcelduff
2008 Hodyl N, Wyper H, Scott NM, Osei-Kumah A, Murphy VE, Smith R, Clifton VL, 'Relationship between placental glucocorticoid receptor expression and fetal growth in pregnancies complicated by asthma', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book (2008) [E3]
Co-authors Vicki Clifton, Vanessa Murphy
2008 Rae KM, Hollebone K, Apen K, Martin T, Smith R, 'Investigating life event stress could help reduce the incidence of preterm birth in Aboriginal Australians', Aboriginal Health Research Conference 2008: Conference Program and Abstract Book (2008) [E3]
Co-authors Kym Rae
2008 Smith R, Smith JI, Bowman M, Equils O, Vali S, Bisits AM, 'Use of mathematical modelling to predict pregnancy outcomes and behaviour of the uterus', The Twenty-Second Fetal and Neonatal Workshop of Australia and New Zealand Abstract Book (2008) [E3]
Co-authors Maria Bowman
2008 Chuter VH, Smith R, 'The effect of shoe design on rearfoot kinematics, kinetics and plantar forces', 13th Annual Congress of the European College of Sport Science. Book of Abstracts (2008) [E3]
Co-authors Vivienne Chuter
2007 Tolosa Gonzalez JM, Schjenken JE, Scott NM, Clifton VL, Smith R, 'Immunosuppressive properties of a synthetic peptide analogous to human syncytin immunosuppressive peptide', Endocrine Journal (2007) [E3]
Co-authors Vicki Clifton
2007 Schjenken JE, Tolosa Gonzalez JM, Clifton VL, Smith R, 'Potential role of CRH in mediating immune function in pregnancy', Endocrine Journal (2007) [E3]
Co-authors Vicki Clifton
2007 Hure AJ, Young AF, Smith R, Collins CE, 'Is diet quality higher during pregnancy?', Journal of Paediatrics and Child Health (2007) [E3]
Co-authors Clare Collins, Alexis Hure, Anne Young
2007 Scott NM, Stark MJ, Wright IM, Hodgson DM, Smith R, Clifton VL, 'Placental inflammatory response in pregnancies complicated by preterm delivery or asthma', Journal of Paediatrics and Child Health (2007) [E3]
Co-authors Ian Wright, Vicki Clifton, Deborah Hodgson
2007 Bisits AM, Smith R, Macintyre DA, Kwek K, Yeo G, Taylor KA, Chan EC, 'Causal pathway modelling of mRNA data supports inflammatory drive towards labor onset', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI) (2007) [E3]
2007 Smith R, Smith J, Bowman M, McGrath SA, Giles WB, 'Rate of change of corticotrophin releasing hormone and hCG nadir provide accurate identification of women at risk of preterm birth', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI) (2007) [E3]
Co-authors Maria Bowman
2007 Tolosa Gonzalez JM, Schjenken JE, Clifton VL, Smith R, 'Evidence for syncytin expression in human placental exosomes', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI) (2007) [E3]
Co-authors Vicki Clifton
2007 Tyson EK, Macintyre DA, Smith R, Chan EC, Read MA, 'A novel mode of action for oxytocin and cyclic nucleotides in the regulation of myometrial contractility', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI) (2007) [E3]
2007 Macintyre DA, Read MA, Smith R, Tyson EK, Kwek K, Yeo G, Chan EC, 'Evidence for a novel mechanism for human myometrial activation', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI) (2007) [E3]
2007 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal corticosterone receptor abundance and circulating corticosterone', Early Human Development (2007) [E3]
Co-authors Vicki Clifton, Deborah Hodgson, Philip Hansbro, Olivia Wynne, Jay Horvat
2007 Hure AJ, Smith R, Giles WB, Somerset DA, Collins CE, 'Fetal fatness is not associated with maternal adiposity in pregnancy', Early Human Development (2007) [E3]
Co-authors Alexis Hure, Clare Collins
2007 Schjenken JE, Tolosa Gonzalez JM, Civiti TD, Clifton VL, Smith R, 'An improved method to simultaneously extract DNA, RNA and protein from the same sample', Endocrine Journal (2007) [E3]
Co-authors Vicki Clifton
2007 Shipman KL, Smith R, Nicholson RC, 'Investigation into the effect of CREAP on CRH promoter activity in JEG-3 cells', Endocrine Journal (2007) [E3]
2007 Smith R, 'Turning on the uterus: How the clock works and the womb wakes', Journal of Paediatrics and Child Health (2007) [E3]
2007 Smith R, Leong A, Norman JE, 'Endothelial and myometrial cell changes in the human uterus at term', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI) (2007) [E3]
2007 Scott NM, Stark MJ, Wright IM, Hodgson DM, Smith R, Clifton VL, 'Response of placental explants from term and preterm pregnancies to an immune challenge', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI) (2007) [E3]
Co-authors Ian Wright, Vicki Clifton, Deborah Hodgson
2007 Nicholson RC, Uh A, Smith R, Equils O, 'Stimulation of toll-like receptors (TLR) increases CRH expression in placenta', Program & Abstracts: The Endocrine Society's 89th Annual Meeting ENDO 07 (2007) [E3]
2007 Shen X, Smith D, Smith R, Smith J, 'Computer visualisation of interrelationships between multiple variables across human pregnancy', Proceedings 4th International Conference Medical Information Visualisation: BioMedical Visualisation: MediViz 2007 (2007) [E1]
2006 Power ML, Bowman M, Smith R, Layne DG, Ziegler TE, Tardif SD, Schulkin J, 'Expression and function of corticotropin-releasing hormone (crh) in anthropoid primate placenta', American Journal of Primatology (2006) [E3]
Co-authors Maria Bowman
2006 Macintyre DA, Read MA, Smith R, Tyson EK, Yeo GS, Kwek K, Chan EC, 'Evidence for a novel mechanism for human myometrial activation', Endocrine Journal-Continuation of Endocrinologia Japonica (2006) [E3]
2006 Tyson EK, Macintyre DA, Smith R, Chan EC, Read MA, 'A novel mode of action for oxytocin and camp in regulating myometrial contractility', Endocrine Journal-Continuation of Endocrinologia Japonica (2006) [E3]
2006 Minahan KL, Clulow J, Mahony MJ, Smith R, Fitter JT, 'Different environmental stresses elicit differential CRH responses in limnodynastes peronii', Endocrine Journal-Continuation of Endocrinologia Japonica (2006) [E3]
Co-authors John Clulow, John Fitter
2006 King BR, Smith R, Nicholson RC, 'cAMP regulates CRH gene expression through a multi-element response unit', Endocrine Journal-Continuation of Endocrinologia Japonica (2006) [E3]
Co-authors Bruce King
2006 Smith J, Norris A, Bowman M, Engel T, Bisits AM, Giles WB, et al., 'Rate of change of corticotrophin releasing hormone and HCG Nadir provide accurate identification of women at risk of preterm birth', Endocrine Journal-Continuation of Endocrinologia Japonica (2006) [E3]
Co-authors Maria Bowman
2006 Scott NM, Stark MJ, Wright IM, Hodgson DM, Smith R, Clifton VL, 'Differences in tumour mecrosis factor alpha production by term and preterm placentae', Endocrine Journal-Continuation of Endocrinologia Japonica (2006) [E3]
Co-authors Ian Wright, Vicki Clifton, Deborah Hodgson
2006 Hure AJ, Smith R, Collins CE, 'Energy intake versus expenditure in breastfed infants: Aren't we missing something?', Nutrition & Dietetics (2006) [E3]
Co-authors Clare Collins, Alexis Hure
2006 Hure AJ, Smith R, Collins CE, 'Methodological barriers to studying the predictive adaptive response in humans', Obesity Reviews (2006) [E3]
Co-authors Clare Collins, Alexis Hure
2006 Hure AJ, Young AF, Smith R, Collins CE, 'A comparison of diet quality in young Australian women according to pregnancy status', Asia Pacific Journal of Clinical Nutrition (2006) [E3]
Co-authors Clare Collins, Alexis Hure, Anne Young
2006 Tyson EK, Smith R, Read MA, 'Effect of progesterone pretreatment on myometrial contractile responses to corticotrophin releasing hormone and rolipram (Poster presentation)', Journal of the Society for Gynecologic Investigation (Vol 13, No. 2 Supp 1) (2006) [E3]
2006 Macintyre DA, Read MA, Smith R, Tyson EK, Yeo G, Kwek K, Chan EC, 'Onset of human myometrium activation at labor is associated with increased phosphorylation of heat shock protein 27 and decreased levels of heat shock protein 20 (Poster presentation)', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 237) Scientific Program and Abstracts 53rd Annual Meeting - March 22-25, 2006 Toronto, Ontario (2006) [E3]
2006 Clifton VL, Wyper H, Smith R, Johnson R, Osei-Kumah A, 'Placental glucocorticoid receptor expression in pregnancies complicated by asthma.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2006)
2006 Tyson E, Smith R, Read M, 'Effect of progesterone pretreatment on myometrial contractile responses to corticotrophin releasing hormone and rolipram.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2006)
2006 Osei-Kumah A, Ammit A, Smith R, Clifton VL, 'Maternal and cord plasma cytokine profiles in pregnancies complicated by asthma.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2006)
2006 Clifton VL, Wyper H, Smith R, Johnson RF, Osei-Kumah A, 'Placental glucocorticoid receptor expression in pregnancies complicated by asthma (poster presentation)', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 667) Scientific Program and Abstracts 53rd Annual Meeting (2006) [E3]
Co-authors Vicki Clifton
2006 Osei-Kumah A, Ammit A, Smith R, Clifton VL, 'Maternal and cord plasma cytokine profiles in pregnancies complicated by asthma (Poster presentation)', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 667) Scientific Program and Abstracts 53rd Annual Meeting (2006) [E3]
Co-authors Vicki Clifton
2006 Scott NM, Wyper HJ, Osei-Kumah A, Smith R, Murphy VE, Clifton VL, 'Sex specific differences in placental cytokine expression and their relationship to fetal glucocorticoid exposure', Journal of the Society for Gynecologic Investigation. Scientific Program and Abstracts 53rd Annual Meeting (2006) [E3]
Co-authors Vicki Clifton, Vanessa Murphy
2005 Gibson PG, Giles WB, Zakar T, Smith R, Kessell CG, Clifton VL, Murphy VE, 'Inflammatory factors have sex-specified effects on fetal growth in humans', Ceska Gynekologie (2005) [C3]
Co-authors Vicki Clifton, Vanessa Murphy, Peter Gibson
2005 Fittock R, Murphy VE, Smith R, Zarzycki PK, Clifton VL, 'Metabolism of synthetic glucocorticoids used for the treatment of asthma by placental 11beta-hydoxysteroid dehydrogenase 2', Endocrine Society of Australia Annual Scientific Meeting, Adelaide, 22-25 Sept, 2002 (2005) [E3]
Co-authors Vicki Clifton, Vanessa Murphy
2005 King BR, Edwards (Ext) M, Smith R, Scheffer I, 'Doublecortin gene defects. Are they a cause of pseudopseudohypoparathyrodisim?', Hormone Research (2005) [E3]
Co-authors Bruce King
2005 Clifton VL, Murphy VE, Gibson PG, Smith R, Giles WB, Scott N, 'Gender specific differences in response to changes in glucocorticoid concentration in the human fetus: Relationship to birthweight', PEDIATRIC RESEARCH (2005)
Co-authors Peter Gibson, Vanessa Murphy
2004 Nicholson RC, Ni X, Hou Y, Yang R, Tang X, Smith R, 'Progesterone Receptors A and B Differentially Modulate Placental Expression of the CRH Gene Through a CRE', Proceedings of the 12th International Congress of Endocrinology (2004) [E1]
2004 Osei-Kumah A, Smith R, Ge Q, Ammit A, Clifton V, 'Feto-placental derived factors alter cytokine release and cell adhesion molecule expression in bronchial smooth muscle cells', PLACENTA (2004)
2004 Clifton V, Dierkx L, Read M, Smith R, Wright I, 'The role of corticotropin-releasing hormone in the microvascular physiology of pregnancy', PLACENTA (2004)
2004 Bisits AM, Mesiano S, Kwek K, Yeo GSH, Smith R, Chan EC, 'Pathways of gene interactions in the initiation of labour.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2004)
2004 Clifton VL, Murphy VE, Osei-Kumah A, Giles WB, Smith R, Gibson PG, 'Gender specific mechanisms of human fetal cortisol metabolism and immunity.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION (2004)
Co-authors Peter Gibson, Vanessa Murphy
2004 Gibson PG, Murphy VE, Kessell CG, Talbot PI, Giles WB, Smith R, Clifton VL, 'Effect of fetal gender on maternal athsma during pregnancy', American Journal of Respiratory Care (2004) [C3]
Co-authors Vicki Clifton, Vanessa Murphy, Peter Gibson
2004 Talbot PI, Murphy VE, Kessell CG, Giles WB, Smith R, Gibson PG, Clifton VL, 'Effect of fetal gender on maternal asthma during pregnancy', Respirology (2004) [C3]
Co-authors Peter Gibson, Vanessa Murphy, Vicki Clifton
2004 Johnson RF, Mitchell CM, Murphy VE, Wang Y, Akinsanya K, Smith R, Zakar T, 'Proteomic analyss of proteins in the human amnion during late gestation and labor', reproductive Sciences (2004) [C3]
Co-authors Vanessa Murphy
2004 Edwards MJ, Smith R, McKenzie F, Fietz M, 'Siblings with a congential disorder of glycosylation syndrome (CDGS) causing hydrops, contractures, protein losing enteropathy and stillbirth or neonatal death', Conference Abstract (2004) [E3]
2004 Delahunty M, Fittock R, Murphy VE, Smith R, Zarzycki PK, Clifton VL, 'Metabolism of synthetic glucocortcoids used for the treatment of asthma by the human placenta', Conference of the Perinatal Society of Australia and New Zealand, Sydney, 15-19 March, 2004 (2004) [E3]
Co-authors Vicki Clifton, Vanessa Murphy
2004 MacDermot K, Bonora E, McKenzie F, Smith R, Sykes N, Coupe A-M, et al., 'Identification of FOXP2 truncation as a novel cause of nonsyndromic developmental speech disorder', Poster Presentation (2004) [E3]
2003 Murphy VE, Gibson PG, Giles WB, Smith R, Clifton VL, 'A novel model for examining fetal growth restriction in human pregnancy', Reproductive Sciences (2003) [C3]
Co-authors Vanessa Murphy, Vicki Clifton, Peter Gibson
2003 Murphy VE, Johnson RF, Wang Y, Akinsanya K, Gibson PG, Smith R, Clifton VL, 'A proteomic analysis of maternal plasma, umbilical cord plasma and placenta in asthmatic and non-asthmatic pregnancies', Australian Society for Medical Research, National Scientific Conference, Glenelg, 22-24 Nov, 2003 (2003) [E3]
Co-authors Peter Gibson, Vicki Clifton, Vanessa Murphy
2003 Murphy VE, Gibson PG, Giles WB, Smith R, Clifton VL, 'The effect of fetal gender on maternal inflammation and lung function in asthmatic pregnancies', Endocrine Society of Australia Annual Meeting, Melbourne 14-17 Sept, 2003 (2003) [E3]
Co-authors Vanessa Murphy, Peter Gibson, Vicki Clifton
2003 Murphy VE, Gibson PG, Giles WB, Smith R, Zarzycki PK, 'Placental and maternal inflammatory pathways in pregnancies complicated by asthma', Placenta (2003) [C3]
Co-authors Vanessa Murphy, Peter Gibson
2003 Clifton VL, Fittock R, Murphy VE, Smith R, 'Metabolism of semi-synthetic glucocorticoids by the human placenta', Placenta (2003) [C3]
Co-authors Vicki Clifton, Vanessa Murphy
2002 Murphy VE, Zakar T, Smith R, Giles WB, Kessell CG, Clifton VL, 'Maternal asthma affects fetal growth in a gender specific manner and is associated with reduced placental 11beta-HSD2 activity and altered sensitivity to cortisol', Reproductive Sciences (2002) [C3]
Co-authors Vicki Clifton, Vanessa Murphy
2002 Murphy VE, Gibson PG, Giles WB, Zakar T, Smith R, Kessell CG, Clifton VL, 'Sex-specific changes in placental function and fetal growth and development in pregnancies complicated by ashtma', Endocrine Society of Australia Annual Scientific Meeting, Adelaide, 22-25 Sept, 2002 (2002) [E3]
Co-authors Vanessa Murphy, Peter Gibson, Vicki Clifton
2001 Murphy VE, Zakar T, Gibson PG, Giles WB, Smith R, Clifton VL, 'Pleacental 11beta-HSD2 activity in asthmatic women', Reproductive sciences (2001) [C3]
Co-authors Vanessa Murphy, Vicki Clifton, Peter Gibson
2001 Murphy VE, Zakar T, Smith R, Giles WB, Gibson PG, Clifton VL, 'A potential mechnism for growth retardation in pregnancies complicated by asthma', Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, 9-12 Sept, 2001 (2001) [E3]
Co-authors Peter Gibson, Vicki Clifton, Vanessa Murphy
1999 Majzoub JA, McGregor JA, Lockwood CJ, Smith R, Taggart MS, Schulkin J, 'A central theory of preterm and term labor: Putative role for corticotropin-releasing hormone', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (1999)
DOI 10.1016/S0002-9378(99)70707-6
Citations Web of Science - 60
1998 Giles WB, Knox M, Masden G, Bisits AM, Smith R, 'The effect of fetal fibronectin usage on admissions to a tertiary maternal fetal medicine unit and cost saving', American Journal of Obstetrics and Gynecology (1998) [E1]
Citations Scopus - 48Web of Science - 35
Co-authors Gemma Madsen
Show 162 more conferences

Patent (5 outputs)

Year Citation Altmetrics Link
2008 Smith R, Assay for the detection of biomarkers associated with pregnancy disorders (2008) [I2]
2008 Smith R, Detection of biomarkers associated with pregnancy disorders (2008) [I1]
2007 Smith R, Assay for the detection of biomarkers associated with pregnancy related conditions (2007) [I2]
2004 Smith R, Smith DW, A method for analysis of biological systems (2004) [I2]
1995 Smith R, Method for determining term of pregnancy (1995) [I2]
Show 2 more patents

Other (1 outputs)

Year Citation Altmetrics Link
2014 Blumfield ML, Hure AJ, MacDonald-Wicks LK, Smith R, Simpson SJ, Giles WB, et al., 'Dietary balance during pregnancy is associated with fetal adiposity and fat distribution', ( pp.103-104) (2014) [O1]
DOI 10.1159/000356110
Co-authors Lesley Wicks, Alexis Hure, Clare Collins
Edit

Research Supervision

Number of supervisions

Completed17
Current17

Total current UON EFTSL

Masters0.6
PhD4.58

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2017 PhD Pathways to Uterine Activation at Labour
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2016 PhD Impact of Mobile Phone Intervention in Improving Antenatal Care, Skilled Birth Attendant and Postnatal Care Service Utilisation in Ethiopia: A Cluster Randomised Controlled Trial
PhD (Gender & Health), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2016 PhD Impact of Mobile Phone Intervention in Improving Antenatal Care, Skilled Birth Attendant and Postnatal Care Service Utilisation in Ethiopia: A Cluster Randomised Controlled Trial
PhD (Gender & Health), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2016 PhD Pregnancy and Postnatal Nutrition for Child Cognitive Development
PhD (Behavioural Science), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2016 PhD Visualising Life: Illustration as a Vehicle for Communicating the Development and Aging of the Human Placenta
PhD(Natural History Illustrat), Faculty of Science, The University of Newcastle
Co-Supervisor
2016 PhD Visualising Life: Illustration as a Vehicle for Communicating the Development and Aging of the Human Placenta
PhD(Natural History Illustrat), Faculty of Education and Arts, The University of Newcastle
Co-Supervisor
2016 PhD Maternal Mortality and Maternal Health Service Utilization in Eastern Ethiopia: The case of Kersa district
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2016 PhD The Impact Of Antenatal Care On Pregnancy Outcomes in Southern Ethiopia: A Prospective Cohort Study
PhD (Gender & Health), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2016 Masters Role of Protein to Carbohydrate Ratio in Determining Gestational Length and Birth Weight
M Philosophy (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2015 PhD Targeting Thyroid Cancer Cells for Diagnosis and Treatment
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Understanding Human Labour: Emergence of Synchrony in the Myometrium
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Increased Oxidative Damage and Premature Placental Aging Contribute to the Aetiology of Stillbirth
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Pathways to Improving Maternal Mortality in Rural Nepal
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Systemic Dependence Between Leadership and Collaborative Success?
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Development of an Insulin Delivery Algorithm for Management of Meals for Type 1 Diabetes Mellitus in Children
PhD (Paediatrics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Elucidating the Role of Myosin Phosphatase in the Contractility of Myometrial Smooth Muscle
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2009 PhD Epigenetic Regulation of Progesterone Receptor Isoforms in Human Paturition
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2013 Masters Weight Retention in the Postpartum Period
M Philosophy (Nutrition&Diet), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Nutrition During Pregnancy: An Evaluation of Maternal Dietary Intake and the Development of Foetal Adiposity
PhD (Nutrition & Dietetics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Relationship Between Renal Volume, Prematurity, Birth Weight and Retinal Microvasculature
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD Effect of Maternal Asthma During Pregnancy on Aspects of Placental Immune Function
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Human Endogenous Retroviruses and Immune Tolerance in Pregnancy
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2010 PhD Syncytin and Placental Exosomes: New Insights in Immunology of Pregnancy
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2009 PhD Nutritional Influences in Pregnancy and Postpartum for Women and Their Children
PhD (Nutrition & Dietetics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2009 PhD Regulation of Myometrial Contractility: Pathways to Human Birth
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2009 PhD Effect of Maternal Asthma During Pregnancy on Circulating Cytokines, Immune Cell Profile and Airway Inflammatory Mediator Release In-Vitro
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2008 PhD Estrogen and Progesterone Actions in Human Parturition
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2008 PhD Characterisation of the Multifunctional Protein, CREAP
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 PhD A Discovery Approach to Human Labour
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2006 PhD The Control of Prostaglandin Synthesis and Degradation in the Human Fetal Membranes during Pregnancy and Labour
PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2006 PhD Tissue Specific Mechanisms of Transcriptional Regulation of the Corticotrophin-Releasing Hormone Gene
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2004 PhD The Effect of Maternal Asthma During Pregnancy on Placental Function and Fetal Development
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2003 Masters The Use of Ultrasound Measurements to Assess Normal Foetal Growth and Myometrial Tension Throughout Pregnancy. A Longitudinal Study
M MedSc (Medicine) [R], Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2002 PhD Pituitary Autoimmunity: Identification of the First Pituitary Target Autoantigen involved in Two Autoimmune Syndromes and the Clinical Significance of Antipituitary Autoantibodies
PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 287
United States 29
United Kingdom 22
China 14
Singapore 9
More...
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News

Dr Jonathan Paul

Nanotech revolution for pregnancy drugs

September 2, 2016

A revolutionary method of delivering drugs specifically to the uterus, using antibody-coated nanoparticles, has been pioneered by researchers from the University of Newcastle (UON) and Hunter Medical Research Institute.

$1.5 million federal grant secures Indigenous health centre’s future

May 17, 2016

The Federal Government has provided a crucial $1.5 million grant to the University of Newcastle’s Gomeroi gaaynggal health centre at Tamworth and Walgett, enabling it to continue operating beyond the end of 2016.

NHMRC

NHMRC Development Grant 2016

November 13, 2015

Professor Roger Smith has been awarded more than $469,000 in NHMRC Development Grant funding commencing in 2016 for his research project Achieving Targeted Delivery of Drugs to Uterine Muscle in Women for the Prevention of Preterm Labour.

Pregnancy

Key to triggering labour discovered

June 18, 2014

Pioneering research by the University of Newcastle's Mothers and Babies Research Centre has led to the discovery of an electrical 'switch' in the uterine muscle that fails to engage in pregnant women who are overweight, potentially causing labour complications.

The Conversation

Kidney disease in Aboriginal Australians perpetuates poverty

June 10, 2013

By Roger Smith, Director of the Mothers and Babies Research Centre, University of Newcastle and Kirsty Pringle, University of Newcastle

The recent death of the lead singer of Yothu Yindi, is a high-profile example of an event all too common in Aboriginal Australia.

Professor Roger Smith with a baby in an incubator

HMRI Professor Roger Smith is named Member of the Order of Australia

January 26, 2013

University of Newcastle researcher Professor Roger Smith has been named a Member of the Order of Australia (AM) in the 2013 Australia Day Honours list.

Laureate Professor Roger Smith

Position

Laureate Professor
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email roger.smith@newcastle.edu.au
Phone 14376
Fax 14394

Office

Room JHH
Building John Hunter Hospital
Location John Hunter Hospital

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