Dr Rebecca Hood

Dr Rebecca Hood

Postdoctoral Researcher

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

As a Greaves Family post-graduate scholar, Rebecca's doctoral work focused on understanding the mechanisms underlying the pressure rise within the skull after ischaemic stroke (blockage of an artery in the brain). Since completing her PhD, her postdoctoral career is continuing in the stroke research field with Professor Rohan Walker and Professor Michael Nilsson. Here, her research is focused on post-stroke recovery. 


Qualifications

  • Doctor of Philosophy in Human Physiology, University of Newcastle
  • Bachelor of Biomedical Sciences, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Biomedical Sciences - Neuroscience
  • Cerebrospinal Fluid
  • Hypoxia
  • Intracranial Pressure
  • Ischaemic Stroke
  • Medical Physiology

Fields of Research

Code Description Percentage
320506 Medical biochemistry - proteins and peptides (incl. medical proteomics) 25
320903 Central nervous system 75

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Researcher University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
Casual Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Professional appointment

Dates Title Organisation / Department
1/8/2018 -  TACTICS VR Project Manager Faculty of Health and Medicine, The University of Newcastle
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (11 outputs)

Year Citation Altmetrics Link
2021 Bothwell SW, Omileke D, Hood RJ, Pepperall D-G, Azarpeykan S, Patabendige A, Spratt NJ, 'Altered Cerebrospinal Fluid Clearance and Increased Intracranial Pressure in Rats 18 h After Experimental Cortical Ischaemia.', Front Mol Neurosci, 14 712779 (2021)
DOI 10.3389/fnmol.2021.712779
Co-authors Neil Spratt, Adjanie Patabendige
2021 Zalewska K, Hood RJ, Pietrogrande G, Sanchez-Bezanilla S, Ong LK, Johnson SJ, et al., 'Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental stroke', International Journal of Molecular Sciences, 22 (2021) [C1]

White matter tract (WMT) degeneration has been reported to occur following a stroke, and it is associated with post-stroke functional disturbances. White matter pathology has been... [more]

White matter tract (WMT) degeneration has been reported to occur following a stroke, and it is associated with post-stroke functional disturbances. White matter pathology has been suggested to be an independent predictor of post-stroke recovery. However, the factors that influence WMT remodeling are poorly understood. Cortisol is a steroid hormone released in response to prolonged stress, and elevated levels of cortisol have been reported to interfere with brain recovery. The objective of this study was to investigate the influence of corticosterone (CORT; the rodent equivalent of cortisol) on WMT structure post-stroke. Photothrombotic stroke (or sham surgery) was induced in 8-week-old male C57BL/6 mice. At 72 h, mice were exposed to standard drinking water ± CORT (100 µg/mL). After two weeks of CORT administration, mice were euthanised and brain tissue collected for histological and biochemical analysis of WMT (particularly the corpus cal-losum and corticospinal tract). CORT administration was associated with increased tissue loss within the ipsilateral hemisphere, and modest and inconsistent WMT reorganization. Further, a structural and molecular analysis of the WMT components suggested that CORT exerted effects over axons and glial cells. Our findings highlight that CORT at stress-like levels can moderately influence the reorganization and microstructure of WMT post-stroke.

DOI 10.3390/ijms22136693
Co-authors Rohan Walker, Michael Nilsson, Linkooi Ong, Sarah Johnson
2021 Sanchez-Bezanilla S, Hood RJ, Collins-Praino LE, Turner RJ, Walker FR, Nilsson M, Ong LK, 'More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke.', J Cereb Blood Flow Metab, 41 2439-2455 (2021)
DOI 10.1177/0271678X211005877
Citations Scopus - 1
Co-authors Rohan Walker, Linkooi Ong, Michael Nilsson
2021 Zhao Z, Hood RJ, Ong LK, Pietrogrande G, Sanchez Bezanilla S, Warren KE, et al., 'Exploring How Low Oxygen Post Conditioning Improves Stroke-Induced Cognitive Impairment: A Consideration of Amyloid-Beta Loading and Other Mechanisms', FRONTIERS IN NEUROLOGY, 12 (2021) [C1]
DOI 10.3389/fneur.2021.585189
Co-authors Linkooi Ong, Rohan Walker, Michael Nilsson, Marina Ilicic, Sarah Johnson, Murielle Kluge
2019 Patabendige A, MacKovski N, Pepperall D, Hood R, Spratt N, 'A26 Cerebrospinal fluid outflow resistance is increased following small-moderate ischaemic stroke (vol 16, 16, 2019)', FLUIDS AND BARRIERS OF THE CNS, 16 (2019)
DOI 10.1186/s12987-019-0144-7
Co-authors Neil Spratt, Adjanie Patabendige
2018 Tan KN, Hood R, Warren K, Pepperall D, Carrasco-Pozo C, Manzanero S, et al., 'Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats', Neuroscience Letters, 683 207-214 (2018) [C1]

Triheptanoin, the medium-chain triglyceride of heptanoate, has been shown to be anticonvulsant and neuroprotective in several neurological disorders. In the gastrointestinal tract... [more]

Triheptanoin, the medium-chain triglyceride of heptanoate, has been shown to be anticonvulsant and neuroprotective in several neurological disorders. In the gastrointestinal tract, triheptanoin is cleaved to heptanoate, which is then taken up by the blood and most tissues, including liver, heart and brain. Here we evaluated the neuroprotective effects of heptanoate and its effects on mitochondrial oxygen consumption in vitro. We also investigated the neuroprotective effects of triheptanoin compared to long-chain triglycerides when administered after stroke onset in rats. Heptanoate pre-treatment protected cultured neurons against cell death induced by oxygen glucose deprivation and N-methyl-D-aspartate. Incubation of cultured astrocytes with heptanoate for 2 h increased mitochondrial proton leak and also enhanced basal respiration and ATP turnover, suggesting that heptanoate protects against oxidative stress and is used as fuel. However, continuous 72 h infusion of triheptanoin initiated 1 h after middle cerebral artery occlusion in rats did not alter stroke volume at 3 days or neurological deficit at 1 and 3 days relative to long-chain triglyceride control treatment.

DOI 10.1016/j.neulet.2018.07.045
Citations Scopus - 2Web of Science - 2
Co-authors Neil Spratt
2016 Beard DJ, Logan CL, McLeod DD, Hood RJ, Pepperall D, Murtha LA, Spratt NJ, 'Ischemic penumbra as a trigger for intracranial pressure rise - A potential cause for collateral failure and infarct progression?', J Cereb Blood Flow Metab, 36 917-927 (2016) [C1]
DOI 10.1177/0271678X15625578
Citations Scopus - 10Web of Science - 9
Co-authors Damian Mcleod, Daniel J Beard, Lucy Murtha, Neil Spratt
2016 Tomkins AJ, Hood RJ, Pepperall D, Null CL, Levi CR, Spratt NJ, 'Thrombolytic Recanalization of Carotid Arteries Is Highly Dependent on Degree of Stenosis, Despite Sonothrombolysis.', J Am Heart Assoc, 5 (2016) [C1]
DOI 10.1161/JAHA.115.002716
Citations Scopus - 3Web of Science - 2
Co-authors Neil Spratt, Christopher Levi
2015 Mcleod DD, Parsons MW, Hood R, Hiles B, Allen J, Mccann SK, et al., 'Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: Studies in a rat stroke model', International Journal of Stroke, 10 553-559 (2015) [C1]

Background: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stro... [more]

Background: Perfusion computed tomography is becoming more widely used as a clinical imaging tool to predict potentially salvageable tissue (ischemic penumbra) after ischemic stroke and guide reperfusion therapies. Aims: The study aims to determine whether there are important changes in perfusion computed tomography thresholds defining ischemic penumbra and infarct core over time following stroke. Methods: Permanent middle cerebral artery occlusion was performed in adult outbred Wistar rats (n=6) and serial perfusion computed tomography scans were taken every 30 mins for 2h. To define infarction thresholds at 1h and 2h post-stroke, separate groups of rats underwent 1h (n=6) and 2h (n=6) of middle cerebral artery occlusion followed by reperfusion. Infarct volumes were defined by histology at 24h. Co-registration with perfusion computed tomography maps (cerebral blood flow, cerebral blood volume, and mean transit time) permitted pixel-based analysis of thresholds defining infarction, using receiver operating characteristic curves. Results: Relative cerebral blood flow was the perfusion computed tomography parameter that most accurately predicted penumbra (area under the curve=0·698) and also infarct core (area under the curve=0·750). A relative cerebral blood flow threshold of <75% of mean contralateral cerebral blood flow most accurately predicted penumbral tissue at 0·5h (area under the curve=0·660), 1h (area under the curve=0·659), 1·5h (area under the curve=0·636), and 2h (area under the curve=0·664) after stroke onset. A relative cerebral blood flow threshold of <55% of mean contralateral most accurately predicted infarct core at 1h (area under the curve=0·765) and at 2h (area under the curve=0·689) after middle cerebral artery occlusion. Conclusions: The data provide perfusion computed tomography defined relative cerebral blood flow thresholds for infarct core and ischemic penumbra within the first two hours after experimental stroke in rats. These thresholds were shown to be stable to define the volume of infarct core and penumbra within this time window.

DOI 10.1111/ijs.12147
Citations Scopus - 13Web of Science - 13
Co-authors Lucy Murtha, Neil Spratt, Damian Mcleod, Mark Parsons, Christopher Levi
2015 Tomkins AJ, Hood RJ, Levi CR, Spratt NJ, 'Tissue Plasminogen Activator for preclinical stroke research: Neither "rat" nor "human" dose mimics clinical recanalization in a carotid occlusion model', SCIENTIFIC REPORTS, 5 (2015) [C1]
DOI 10.1038/srep16026
Citations Scopus - 9Web of Science - 10
Co-authors Neil Spratt, Christopher Levi
Hair K, Sena ES, Wilson E, Currie G, Macleod M, Bahor Z, et al., 'Building a Systematic Online Living Evidence Summary of COVID-19 Research', Journal of EAHIL, 17 21-26
DOI 10.32384/jeahil17465
Show 8 more journal articles

Conference (8 outputs)

Year Citation Altmetrics Link
2019 Zhao Z, Ong LK, Hood R, Pietrogrande G, Sanchez Bezanilla S, Warren K, et al., 'Low oxygen post-conditioning improves cognition and reduces amyloid beta accumulation post-stroke in mice' (2019)
Co-authors Linkooi Ong, Rohan Walker, Marina Ilicic
2017 Warren KE, Beard DJ, Hood RJ, Spratt NJ, 'Intracranial pressure elevation is delayed following intracerebral hemorrhage in rats', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY (2017)
Co-authors Daniel J Beard, Neil Spratt
2017 Kovacs T, Murtha L, Beard D, McLeod D, Hood R, Garcia-Esperon C, et al., 'A potential cause of early neurological deterioration after mild-moderate ischaemic stroke - raised intracranial pressure at 24 hours', INTERNATIONAL JOURNAL OF STROKE (2017)
Co-authors Christopher Levi, Daniel J Beard, Damian Mcleod, Neil Spratt, Lucy Murtha
2017 Hood RJ, McLeod DD, Warren KE, Pepperall D, Spratt NJ, 'Are there factors within cerebrospinal fluid that cause intracranial pressure to rise after subarachnoid hemorrhage?', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Int Soc Cerebral Blood Flow & Metab, Berlin, GERMANY (2017)
Co-authors Neil Spratt, Damian Mcleod
2016 McLeod DD, Murtha LA, Beard DJ, Hood RJ, Logan CL, Pepperall D, Spratt NJ, 'Elevated intracranial pressure following stroke: there's more to the story than cerebral oedema.', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vancouver, CANADA (2016)
Co-authors Neil Spratt, Lucy Murtha, Daniel J Beard, Damian Mcleod
2016 Murtha L, Hood R, Beard D, Pepperall D, McLeod D, Spratt N, 'DELAYED INTRACRANIAL PRESSURE ELEVATION FOLLOWING ISCHEMIC STROKE IS PREVENTED BY EARLY AND SHORT HYPOTHERMIA TREATMENT IN AGED RATS', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vancouver, CANADA (2016)
Co-authors Neil Spratt, Daniel J Beard
2016 Beard DJ, Logan CL, McLeod DD, Hood RJ, Pepperall D, Murtha LA, Spratt NJ, 'MIDDLE CEREBRAL ARTERY OCCLUSION WITH GOOD COLLATERALS CAUSES EARLY INTRACRANIAL PRESSURE ELEVATION POST STROKE', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vancouver, CANADA (2016)
Co-authors Damian Mcleod, Lucy Murtha, Daniel J Beard, Neil Spratt
2016 Hood RJ, McLeod DD, Logan CL, Beard DJ, Li R, Spratt NJ, 'FACTOR(S) WITHIN CEREBROSPINAL FLUID POST-STROKE CAUSE INTRACRANIAL PRESSURE TO RISE IN HUMANS AND ANIMALS', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vancouver, CANADA (2016)
Co-authors Neil Spratt, Damian Mcleod, Daniel J Beard
Show 5 more conferences
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Grants and Funding

Summary

Number of grants 3
Total funding $194,430

Click on a grant title below to expand the full details for that specific grant.


20201 grants / $169,000

Development, Implementation and Evaluation of State-wide Mixed Reality based training platform for Telestroke$169,000

Funding body: NSW Agency for Clinical Innovation (ACI)

Funding body NSW Agency for Clinical Innovation (ACI)
Project Team Professor Rohan Walker, Doctor Steven Maltby, Doctor Rebecca Hood, Doctor Murielle Kluge
Scheme Research Grant
Role Investigator
Funding Start 2020
Funding Finish 2021
GNo G2000809
Type Of Funding C2300 – Aust StateTerritoryLocal – Own Purpose
Category 2300
UON Y

20192 grants / $25,430

FHEAM Equipment Grant$24,630

Funding body: Faculty of Health and Medicine, University of Newcastle

Funding body Faculty of Health and Medicine, University of Newcastle
Scheme FHEAM Equipment Grant Round
Role Lead
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

FHEAM Travel Grant$800

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team

Rebecca Hood

Scheme Travel Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N
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Dr Rebecca Hood

Positions

Postdoctoral Researcher
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Casual Lecturer
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Contact Details

Email rebecca.hood@newcastle.edu.au
Phone (02) 40420223

Office

Room Level 3 East.
Building HMRI
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