Mr Mahmoud Abdolhoseini

Mr Mahmoud Abdolhoseini

Senior Research Assistant

School of Psychology

Career Summary

Biography

Welcome to my university web-page. My current research area is data acquisition, analysis and modelling in Cognitive Neuroscience. Currently, I holding an appointment with the School of Psychology at UON. My research background in Electrical Engineering creates a great knowledge and insight in these fields and enable me to work in a multi-disciplinary research environment collaborating with psychologist and neuroscientist. 

Qualifications

  • Doctor of Philosophy in Electrical Engineering, University of Newcastle
  • Bachelor of Engineering (Electrical), Imam Khomeini International University - Iran
  • Master of Science (Electrical Engineering), Shahid Beheshti University - Iran

Keywords

  • Cognitive Neuroscience
  • Data Analysis and Modelling
  • Signal and Image Processing

Languages

  • Persian (excluding Dari) (Mother)
  • English (Fluent)

Fields of Research

Code Description Percentage
179999 Psychology and Cognitive Sciences not elsewhere classified 50
090699 Electrical and Electronic Engineering not elsewhere classified 50
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (7 outputs)

Year Citation Altmetrics Link
2019 Abdolhoseini M, Kluge MG, Walker FR, Johnson SJ, 'Segmentation, Tracing, and Quantification of Microglial Cells from 3D Image Stacks', SCIENTIFIC REPORTS, 9 (2019) [C1]
DOI 10.1038/s41598-019-44917-6
Co-authors Sarah Johnson, Murielle Kluge, Rohan Walker
2019 Abdolhoseini M, Kluge MG, Walker FR, Johnson SJ, 'Segmentation of Heavily Clustered Nuclei from Histopathological Images', SCIENTIFIC REPORTS, 9 (2019) [C1]
DOI 10.1038/s41598-019-38813-2
Citations Scopus - 1
Co-authors Rohan Walker, Sarah Johnson, Murielle Kluge
2019 Pietrogrande G, Zalewska K, Zhao Z, Abdolhoseini M, Chow WZ, Sanchez-Bezanilla S, et al., 'Low oxygen post conditioning prevents thalamic secondary neuronal loss caused by excitotoxicity after cortical stroke', SCIENTIFIC REPORTS, 9 (2019) [C1]
DOI 10.1038/s41598-019-39493-8
Citations Scopus - 1Web of Science - 1
Co-authors Linkooi Ong, Michael Nilsson, Rohan Walker, Sarah Johnson
2019 Kluge MG, Abdolhoseini M, Zalewska K, Ong LK, Johnson SJ, Nilsson M, Walker FR, 'Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 39 2456-2470 (2019) [C1]
DOI 10.1177/0271678X18797346
Citations Scopus - 9Web of Science - 8
Co-authors Rohan Walker, Michael Nilsson, Sarah Johnson, Murielle Kluge, Linkooi Ong
2018 Pietrogrande G, Mabotuwana N, Zhao Z, Abdolhoseini M, Johnson SJ, Nilsson M, Walker FR, 'Chronic stress induced disturbances in Laminin: A significant contributor to modulating microglial pro-inflammatory tone?', BRAIN BEHAVIOR AND IMMUNITY, 68 23-33 (2018) [C1]
DOI 10.1016/j.bbi.2017.09.012
Citations Scopus - 4Web of Science - 4
Co-authors Michael Nilsson, Sarah Johnson, Rohan Walker
2018 Zalewska K, Pietrogrande G, Ong LK, Abdolhoseini M, Kluge M, Johnson SJ, et al., 'Sustained administration of corticosterone at stress-like levels after stroke suppressed glial reactivity at sites of thalamic secondary neurodegeneration', Brain, Behavior, and Immunity, 69 210-222 (2018) [C1]

© 2017 Elsevier Inc. Secondary neurodegeneration (SND) is an insidious and progressive condition involving the death of neurons in regions of the brain that were connected to but ... [more]

© 2017 Elsevier Inc. Secondary neurodegeneration (SND) is an insidious and progressive condition involving the death of neurons in regions of the brain that were connected to but undamaged by the initial stroke. Our group have published compelling evidence that exposure to psychological stress can significantly exacerbate the severity SND, a finding that has considerable clinical implications given that stroke-survivors often report experiencing high and unremitting levels of psychological stress. It may be possible to use one or more targeted pharmacological approaches to limit the negative effects of stress on the recovery process but in order to move forward with this approach the most critical stress signals have to be identified. Accordingly, in the current study we have directed our attention to examining the potential effects of corticosterone, delivered orally at stress-like levels. Our interest is to determine how similar the effects of corticosterone are to stress on repair and remodelling that is known to occur after stroke. The study involved 4 groups, sham and stroke, either administered corticosterone or normal drinking water. The functional impact was assessed using the cylinder task for paw asymmetry, grid walk for sensorimotor function, inverted grid for muscle strength and coordination and open field for anxiety-like behaviour. Biochemically and histologically, we considered disturbances in main cellular elements of the neurovascular unit, including microglia, astrocytes, neurons and blood vessels using both immunohistochemistry and western blotting. In short, we identified that corticosterone delivery after stroke results in significant suppression of key microglial and astroglial markers. No changes were observed on the vasculature and in neuronal specific markers. No changes were identified for sensorimotor function or anxiety-like behaviour. We did, however, observe a significant change in motor function as assessed using the inverted grid walk test. Collectively, these results suggest that pharmacologically targeting corticosterone levels in the future may be warranted but that such an approach is unlikely to limit all the negative effects associated with exposure to chronic stress.

DOI 10.1016/j.bbi.2017.11.014
Citations Scopus - 6Web of Science - 6
Co-authors Linkooi Ong, Sarah Johnson, Michael Nilsson, Rohan Walker, Murielle Kluge
2017 Kluge MG, Kracht L, Abdolhoseini M, Ong LK, Johnson SJ, Nilsson M, Walker FR, 'Impaired microglia process dynamics post-stroke are specific to sites of secondary neurodegeneration', GLIA, 65 1885-1899 (2017) [C1]

© 2017 Wiley Periodicals, Inc. Stroke induces tissue death both at the site of infarction and at secondary sites connected to the primary infarction. This latter process has been ... [more]

© 2017 Wiley Periodicals, Inc. Stroke induces tissue death both at the site of infarction and at secondary sites connected to the primary infarction. This latter process has been referred to as secondary neurodegeneration (SND). Using predominantly fixed tissue analyses, microglia have been implicated in regulating the initial response at both damage sites post-stroke. In this study, we used acute slice based multiphoton imaging, to investigate microglia dynamic process movement in mice 14 days after a photothrombotic stroke. We evaluated the baseline motility and process responses to locally induced laser damage in both the peri-infarct (PI) territory and the ipsilateral thalamus, a major site of post-stroke SND. Our findings show that microglia process extension toward laser damage within the thalamus is lost, yet remains robustly intact within the PI territory. However, microglia at both sites displayed an activated morphology and elevated levels of commonly used activation markers (CD68, CD11b), indicating that the standardly used fixed tissue metrics of microglial ¿activity¿ are not necessarily predictive of microglia function. Analysis of the purinergic P2Y12 receptor, a key regulator of microglia process extension, revealed an increased somal localization on nonresponsive microglia in the thalamus. To our knowledge, this is the first study to identify a non-responsive microglia phenotype specific to areas of SND post-stroke, which cannot be identified by the classical assessment of microglia activation but rather the localization of P2Y12 to the soma.

DOI 10.1002/glia.23201
Citations Scopus - 14Web of Science - 11
Co-authors Linkooi Ong, Sarah Johnson, Michael Nilsson, Murielle Kluge, Rohan Walker
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Conference (2 outputs)

Year Citation Altmetrics Link
2019 Abdolhoseini M, Klugen MG, Walker FR, Johnson SJ, 'Neuron image synthesizer via gaussian mixture model and perlin noise', 2019 IEEE 16th International Symposium On Biomedical Imaging (ISBI 2019), Venice, ITALY (2019) [E1]
DOI 10.1109/ISBI.2019.8759471
Co-authors Murielle Kluge, Sarah Johnson, Rohan Walker
2016 Abdolhoseini M, Walker F, Johnson SJ, 'Automated Tracing of Microglia Using Multilevel Thresholding and Minimum Spanning Trees', 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Florida, USA (2016) [E1]
DOI 10.1109/EMBC.2016.7590922
Citations Scopus - 5Web of Science - 6
Co-authors Rohan Walker, Sarah Johnson
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Mr Mahmoud Abdolhoseini

Position

Senior Research Assistant
School of Psychology
Faculty of Science

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