
Dr Kirsten Coupland
Postdoctoral Researcher
School of Biomedical Sciences and Pharmacy (Human Physiology)
- Email:kirsten.coupland@newcastle.edu.au
- Phone:(02) 4921 16903
Career Summary
Biography
Dr. Kirsten Coupland is a postdoctoral researcher based at the Hunter Medical Research Institute (HMRI) and the University of Newcastle. Her current research examines the molecular basis of post-stroke outcomes, the results of which she aims to see implemented in a clinical setting.
Dr. Coupland was awarded her PhD from the University of New South Wales in 2015 for her work examining the expression of the microtubule associated protein tau (MAPT) gene in late-onset neurodegenerative disease and its association with disease risk and modifiable lifestyle factors. Under the supervision of Dr. Carol Dobson-Stone and A/Prof. John Kwok, Kirsten’s work identified multiple genetic factors with the potential to contribute to neurodegenerative disease risk. Her work led to the finding that increased DNA methylation (a modifiable epigenetic mark) of MAPT was associated with delayed onset of Parkinson’s disease, and that this methylation was modifiable by vitamin E. These findings led to two awards and an invitation by the Royal Society to present at the Commonwealth Science Conference in Bangalore, India.
Following her PhD, Kirsten took up a postdoctoral position at Karolsinka Institutet, Sweden in the lab of A/Prof Helena Karlström to examine the molecular underpinnings of an inherited vascular dementia (CADASIL). This condition arises due to mutations in a single gene (NOTCH3) and manifests as a series of small strokes that damage the brain and lead to memory impairment. This work focused on the development of a therapy that directs the immune system to remove a toxic build-up of protein in order to pre-emptively treat CADASIL. Her research at Karolinska Institutet resulted in the securing of several competitive grants that continue to fund this important work. In recognition of her skills and experience in neurodegenerative disease and vasculature, Kirsten was recruited to the labs of Prof. Neil Spratt and A/Prof Rohan Walker in May 2018 under the prestigious Dalara Foundation fellowship where she will investigate new targets for post-stroke therapy to improve patient outcomes.
Qualifications
- Doctor of Philosophy, University of New South Wales
- Bachelor of Science (Honours), University of New South Wales
- Diploma in Innovation Management, University of New South Wales
Keywords
- Cerebrovasculature
- Epigenetics
- Glymphatics
- Neurodegeneration
- Neuroscience
- Stroke
Languages
- English (Mother)
Professional Experience
UON Appointment
Title | Organisation / Department |
---|
Academic appointment
Dates | Title | Organisation / Department |
---|---|---|
16/2/2015 - 27/4/2018 | Postdoctoral Researcher | Karolinska Institute Neurobiology, Care Science and Society Sweden |
1/3/2010 - 23/12/2011 | Research Assistant | NeuRA Ageing and Neurodegeneration Australia |
Awards
Prize
Year | Award |
---|---|
2012 |
Junior Oral Presentation Prize Prince of Wales Childrens Hospital |
2012 |
Student Oral Presentation Australasian GeneMappers Conference |
Invitations
Participant
Year | Title / Rationale |
---|---|
2015 | Synthetic Biology Summer School |
Speaker
Year | Title / Rationale |
---|---|
2014 | Commonwealth Science Conference |
2013 | Amplify Festival Brightsparks |
Teaching
Code | Course | Role | Duration |
---|---|---|---|
0000 |
Erasmus Internship Karolinska Institute |
In-lab supervisor | 13/4/2015 - 14/9/2015 |
0000 |
Erasmus internship Karolinska Institute |
In-lab supervisor | 4/9/2017 - 4/12/2017 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (8 outputs)
Year | Citation | Altmetrics | Link | |||||
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2020 |
Hinwood M, Ilicic M, Gyawali P, Kluge MG, Coupland K, Smith A, et al., 'Exploration of stress management interventions to address psychological stress in stroke survivors: a protocol for a scoping review', BMJ OPEN, 10 (2020)
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2018 |
Panahi M, Mesri NY, Samuelsson E-B, Coupland KG, Forsell C, Graff C, et al., 'Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGF beta expression', JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 22 3016-3024 (2018)
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2018 |
Coupland K, Lendahl U, Karlström H, 'Role of NOTCH3 mutations in the cerebral small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy', Stroke, 49 2793-2800 (2018)
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2016 |
Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease', PLOS ONE, 11 (2016)
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2015 |
Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Effect of PSEN1 Mutations on MAPT Methylation in Early-Onset Alzheimer's Disease', CURRENT ALZHEIMER RESEARCH, 12 745-751 (2015)
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2014 |
Coupland KG, Mellick GD, Silburn PA, Mather K, Armstrong NJ, Sachdev PS, et al., 'DNA Methylation of the MAPT Gene in Parkinson's Disease Cohorts and Modulation by Vitamin E In Vitro', MOVEMENT DISORDERS, 29 1606-1614 (2014)
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Show 5 more journal articles |
Conference (1 outputs)
Year | Citation | Altmetrics | Link |
---|---|---|---|
2015 | Kwok J, Coupland K, Mellick G, Mather K, Thalamuthu A, Armstrong N, et al., 'Genome-wide association study identifies the SLC2A14 gene on chromosome 12P13 as a trans-acting locus for methylation of MAPT gene', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015) |
Grants and Funding
Summary
Number of grants | 14 |
---|---|
Total funding | $850,362 |
Click on a grant title below to expand the full details for that specific grant.
20201 grants / $12,162
Mapping changes in cerebrospinal fluid composition after stroke to identify novel therapeutic targets for future drug discovery.$12,162
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Doctor Kirsten Coupland, Professor Neil Spratt, Doctor David Skerrett-Byrne |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2020 |
GNo | G2000282 |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | Y |
20182 grants / $33,400
New tools to tackle familial vascular dementia$19,400
Funding body: Karolinska Institutet
Funding body | Karolinska Institutet |
---|---|
Scheme | Karolinska Institutet Forskningsbidrag |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
New tools to tackle familial vascular dementia$14,000
Funding body: Karolinska Institutet
Funding body | Karolinska Institutet |
---|---|
Scheme | Karolinska Institutet Fonden Geriatrik |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2020 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
20174 grants / $761,500
HMRI Early Career Research Fellowship in Stroke$712,500
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Neil Spratt, Doctor Kirsten Coupland |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2017 |
Funding Finish | 2022 |
GNo | G1701347 |
Type Of Funding | C3120 - Aust Philanthropy |
Category | 3120 |
UON | Y |
Understanding the role of Notch3 in familial vascular dementia and its potential use in immunotherapies$21,000
Funding body: Karolinska Institutet Fonden Geriatrik
Funding body | Karolinska Institutet Fonden Geriatrik |
---|---|
Scheme | Karolinska Institutet Fonden Geriatrik |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Research Grant$17,000
Funding body: Loo och Hans Ostermans
Funding body | Loo och Hans Ostermans |
---|---|
Scheme | Loo och Hans Ostermans |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Foundation Grant$11,000
Funding body: Gamla Tjänarinnor
Funding body | Gamla Tjänarinnor |
---|---|
Scheme | Gamla Tjänarinnor |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
20164 grants / $20,000
Institutional grant$8,300
Funding body: Karolinska Institutet Fonden Geriatrik
Funding body | Karolinska Institutet Fonden Geriatrik |
---|---|
Scheme | Karolinska Institutet Fonden Geriatrik |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Foundation Grant$5,000
Funding body: Gamla Tjänarinnor
Funding body | Gamla Tjänarinnor |
---|---|
Scheme | Gamla Tjänarinnor |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Research Grant$4,200
Funding body: Strokeförbundet
Funding body | Strokeförbundet |
---|---|
Scheme | Strokeförbundet |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Research Grant$2,500
Funding body: Stohnes Stiftelse
Funding body | Stohnes Stiftelse |
---|---|
Scheme | Stohnes Stiftelse |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
20153 grants / $23,300
Institutional grant$15,000
Funding body: Karolinska Institutet Fonden Geriatrik
Funding body | Karolinska Institutet Fonden Geriatrik |
---|---|
Scheme | Karolinska Institutet Fonden Geriatrik |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2016 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Foundation Grant$6,700
Funding body: Gamla Tjänarinnor
Funding body | Gamla Tjänarinnor |
---|---|
Scheme | Gamla Tjänarinnor |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2016 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Research Grant$1,600
Funding body: Stohnes Stiftelse
Funding body | Stohnes Stiftelse |
---|---|
Scheme | Stohnes Stiftelse |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2016 |
GNo | |
Type Of Funding | International - Non Competitive |
Category | 3IFB |
UON | N |
Research Collaborations
The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.
Country | Count of Publications | |
---|---|---|
Australia | 7 | |
Sweden | 4 | |
United States | 2 | |
Finland | 1 | |
United Kingdom | 1 | |
More... |
Dr Kirsten Coupland
Position
Postdoctoral Researcher
Spratt Lab
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Focus area
Human Physiology
Contact Details
kirsten.coupland@newcastle.edu.au | |
Phone | (02) 4921 16903 |
Mobile | +61 402 180 915 |
Office
Room | MS-502 |
---|---|
Building | Medical Sciences Building |
Location | Callaghan University Drive Callaghan, NSW 2308 Australia |