Dr Kirsten Coupland
Postdoctoral Researcher
School of Biomedical Sciences and Pharmacy (Human Physiology)
- Email:kirsten.coupland@newcastle.edu.au
- Phone:(02) 49217402
Career Summary
Biography
Dr. Kirsten Coupland is the inaugural Hunter Medical Research Institute Dalara Early Career Research Fellow. Dr. Coupland has spent her career understanding the molecular underpinnings of complex neurological disease, with the ultimate goal of identifying novel therapeutic targets. This research has taken her from understanding the epigenetic underpinnings of idiopathic neurodegenerative disease through to developing a pre-clinical immunotherapy capable of preventing aggregation of a protein involved in the pathogenesis of an inherited vascular dementia (CADASIL). Dr. Coupland was awarded her PhD from the University of New South Wales in 2015. Following a postdoctoral position at Karolinska Institutet, Sweden she was recruited to join the Translational Stroke Team at the University of Newcastle in 2018 where her molecular expertise is helping to understand how altered cerebrospinal fluid composition and dynamics impact on stroke outcome. Her work has garnered international attention having been invited to speak at several conferences, resulting in 10 publications (5 first author) and three awards. She is a founder and co-executive chair of the stroke coalition of preclinical researchers, an Australasian research body that provides a platform for collaboration and resource sharing among pre-clinical stroke research groups. When she isn’t doing research, Dr. Coupland is doing her best to imitate a pirate by living on a boat and drinking rum. She is yet to procure a parrot.
Qualifications
- Doctor of Philosophy, University of New South Wales
- Bachelor of Science (Honours), University of New South Wales
- Diploma in Innovation Management, University of New South Wales
Keywords
- Cerebrospinal fluid
- Cerebrovasculature
- Glymphatics
- Neurodegeneration
- Neuroscience
- Stroke
Languages
- English (Mother)
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 320199 | Cardiovascular medicine and haematology not elsewhere classified | 30 |
| 320899 | Medical physiology not elsewhere classified | 30 |
| 320903 | Central nervous system | 40 |
Professional Experience
UON Appointment
| Title | Organisation / Department |
|---|---|
| Postdoctoral Researcher | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
| Casual Lecturer | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
| Postdoctoral Researcher | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Academic appointment
| Dates | Title | Organisation / Department |
|---|---|---|
| 16/2/2015 - 27/4/2018 | Postdoctoral Researcher | Karolinska Institute Neurobiology, Care Science and Society Sweden |
| 1/3/2010 - 23/12/2011 | Research Assistant | NeuRA Ageing and Neurodegeneration Australia |
Awards
Prize
| Year | Award |
|---|---|
| 2012 |
Junior Oral Presentation Prize Prince of Wales Childrens Hospital |
| 2012 |
Student Oral Presentation Australasian GeneMappers Conference |
Invitations
Participant
| Year | Title / Rationale |
|---|---|
| 2015 | Synthetic Biology Summer School |
Speaker
| Year | Title / Rationale |
|---|---|
| 2014 | Commonwealth Science Conference |
| 2013 | Amplify Festival Brightsparks |
Teaching
| Code | Course | Role | Duration |
|---|---|---|---|
| PHAR6704 |
Pharmacology of chronic conditions School of Biomedical Sciences and Pharmacy |
Lecturer | 1/3/2021 - 25/6/2021 |
| HUBS2407 |
Experimental design and laboratory skills in medical research School of Biomedical Sciences and Pharmcy, The University of Newcastle |
Lecturer | 2/3/2020 - 26/6/2020 |
| 0000 |
Erasmus Internship Karolinska Institute |
In-lab supervisor | 13/4/2015 - 14/9/2015 |
| 0000 |
Erasmus internship Karolinska Institute |
In-lab supervisor | 4/9/2017 - 4/12/2017 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (10 outputs)
| Year | Citation | Altmetrics | Link | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2021 |
Dzator JSA, Howe PRC, Griffiths LR, Coupland KG, Wong RHX, 'Cerebrovascular Function in Hormonal Migraine: An Exploratory Study', FRONTIERS IN NEUROLOGY, 12 (2021) [C1]
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| 2021 |
Omileke D, Bothwell S, Beard D, MacKovski N, Azarpeykan S, Coupland, et al., 'Short-Duration Hypothermia Induction in Rats using
Models for Studies examining Clinical Relevance and
Mechanisms', Jove-Journal of Visualized Experiments, (2021)
|
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| 2020 |
Hinwood M, Ilicic M, Gyawali P, Kluge MG, Coupland K, Smith A, et al., 'Exploration of stress management interventions to address psychological stress in stroke survivors: a protocol for a scoping review', BMJ OPEN, 10 (2020)
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| 2018 |
Coupland K, Lendahl U, Karlström H, 'Role of NOTCH3 mutations in the cerebral small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy', Stroke, 49 2793-2800 (2018)
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| 2016 |
Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease', PLOS ONE, 11 (2016)
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| 2015 |
Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Effect of PSEN1 Mutations on MAPT Methylation in Early-Onset Alzheimer's Disease', CURRENT ALZHEIMER RESEARCH, 12 745-751 (2015)
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| 2014 |
Coupland KG, Mellick GD, Silburn PA, Mather K, Armstrong NJ, Sachdev PS, et al., 'DNA Methylation of the MAPT Gene in Parkinson's Disease Cohorts and Modulation by Vitamin E In Vitro', MOVEMENT DISORDERS, 29 1606-1614 (2014)
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| Show 7 more journal articles | |||||||||||
Conference (1 outputs)
| Year | Citation | Altmetrics | Link |
|---|---|---|---|
| 2015 | Kwok J, Coupland K, Mellick G, Mather K, Thalamuthu A, Armstrong N, et al., 'Genome-wide association study identifies the SLC2A14 gene on chromosome 12P13 as a trans-acting locus for methylation of MAPT gene', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015) |
Grants and Funding
Summary
| Number of grants | 18 |
|---|---|
| Total funding | $865,462 |
Click on a grant title below to expand the full details for that specific grant.
20213 grants / $14,300
The capacity of statins to improve stroke outcome: influence of perfusion lesion volume and collateral supply$10,000
Funding body: Priority Research Centre for Stroke and Brain Injury
| Funding body | Priority Research Centre for Stroke and Brain Injury |
|---|---|
| Project Team | Coupland K. G., Spratt N., Lillicrap T. |
| Scheme | Strategic Investment Grant |
| Role | Lead |
| Funding Start | 2021 |
| Funding Finish | 2021 |
| GNo | |
| Type Of Funding | Other Public Sector - Local |
| Category | 2OPL |
| UON | N |
IBRO Meeting support$2,300
Funding body: International Brain Research Organization
| Funding body | International Brain Research Organization |
|---|---|
| Project Team | Coupland K.G., Rank M., Ong L. K., Hood R., Beard D. |
| Scheme | IBRO meeting support |
| Role | Lead |
| Funding Start | 2021 |
| Funding Finish | 2022 |
| GNo | |
| Type Of Funding | C3212 - International Not for profit |
| Category | 3212 |
| UON | N |
Cardiovascular Research Network Professional Development Award$2,000
Funding body: Cardiovascular Research Network
| Funding body | Cardiovascular Research Network |
|---|---|
| Project Team | Coupland K. G. |
| Scheme | Professional Development Award |
| Role | Lead |
| Funding Start | 2021 |
| Funding Finish | 2021 |
| GNo | |
| Type Of Funding | C3112 - Aust Not for profit |
| Category | 3112 |
| UON | N |
20201 grants / $12,162
Mapping changes in cerebrospinal fluid composition after stroke to identify novel therapeutic targets for future drug discovery.$12,162
Funding body: John Hunter Hospital Charitable Trust
| Funding body | John Hunter Hospital Charitable Trust |
|---|---|
| Project Team | Doctor Kirsten Coupland, Professor Neil Spratt, Doctor David Skerrett-Byrne |
| Scheme | Research Grant |
| Role | Lead |
| Funding Start | 2020 |
| Funding Finish | 2020 |
| GNo | G2000282 |
| Type Of Funding | C3200 – Aust Not-for Profit |
| Category | 3200 |
| UON | Y |
20191 grants / $800
Travel grant$800
Funding body: NEWCASTLE UNIVERSITY
| Funding body | NEWCASTLE UNIVERSITY |
|---|---|
| Project Team | Coupland K. G. |
| Scheme | Faculty of Health and Medicine Travel Grant |
| Role | Lead |
| Funding Start | 2019 |
| Funding Finish | 2019 |
| GNo | |
| Type Of Funding | C3200 – Aust Not-for Profit |
| Category | 3200 |
| UON | N |
20182 grants / $33,400
New tools to tackle familial vascular dementia$19,400
Funding body: Karolinska Institutet
| Funding body | Karolinska Institutet |
|---|---|
| Scheme | Karolinska Institutet Forskningsbidrag |
| Role | Lead |
| Funding Start | 2018 |
| Funding Finish | 2019 |
| GNo | |
| Type Of Funding | Internal |
| Category | INTE |
| UON | N |
New tools to tackle familial vascular dementia$14,000
Funding body: Karolinska Institutet
| Funding body | Karolinska Institutet |
|---|---|
| Scheme | Karolinska Institutet Fonden Geriatrik |
| Role | Lead |
| Funding Start | 2018 |
| Funding Finish | 2020 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
20174 grants / $761,500
HMRI Early Career Research Fellowship in Stroke$712,500
Funding body: Hunter Medical Research Institute
| Funding body | Hunter Medical Research Institute |
|---|---|
| Project Team | Professor Neil Spratt, Doctor Kirsten Coupland |
| Scheme | Project Grant |
| Role | Investigator |
| Funding Start | 2017 |
| Funding Finish | 2022 |
| GNo | G1701347 |
| Type Of Funding | C3300 – Aust Philanthropy |
| Category | 3300 |
| UON | Y |
Understanding the role of Notch3 in familial vascular dementia and its potential use in immunotherapies$21,000
Funding body: Karolinska Institutet Fonden Geriatrik
| Funding body | Karolinska Institutet Fonden Geriatrik |
|---|---|
| Scheme | Karolinska Institutet Fonden Geriatrik |
| Role | Lead |
| Funding Start | 2017 |
| Funding Finish | 2018 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
Research Grant$17,000
Funding body: Loo och Hans Ostermans
| Funding body | Loo och Hans Ostermans |
|---|---|
| Scheme | Loo och Hans Ostermans |
| Role | Lead |
| Funding Start | 2017 |
| Funding Finish | 2018 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
Foundation Grant$11,000
Funding body: Gamla Tjänarinnor
| Funding body | Gamla Tjänarinnor |
|---|---|
| Scheme | Gamla Tjänarinnor |
| Role | Lead |
| Funding Start | 2017 |
| Funding Finish | 2018 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
20164 grants / $20,000
Institutional grant$8,300
Funding body: Karolinska Institutet Fonden Geriatrik
| Funding body | Karolinska Institutet Fonden Geriatrik |
|---|---|
| Scheme | Karolinska Institutet Fonden Geriatrik |
| Role | Lead |
| Funding Start | 2016 |
| Funding Finish | 2017 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
Foundation Grant$5,000
Funding body: Gamla Tjänarinnor
| Funding body | Gamla Tjänarinnor |
|---|---|
| Scheme | Gamla Tjänarinnor |
| Role | Lead |
| Funding Start | 2016 |
| Funding Finish | 2017 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
Research Grant$4,200
Funding body: Strokeförbundet
| Funding body | Strokeförbundet |
|---|---|
| Scheme | Strokeförbundet |
| Role | Lead |
| Funding Start | 2016 |
| Funding Finish | 2017 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
Research Grant$2,500
Funding body: Stohnes Stiftelse
| Funding body | Stohnes Stiftelse |
|---|---|
| Scheme | Stohnes Stiftelse |
| Role | Lead |
| Funding Start | 2016 |
| Funding Finish | 2017 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
20153 grants / $23,300
Institutional grant$15,000
Funding body: Karolinska Institutet Fonden Geriatrik
| Funding body | Karolinska Institutet Fonden Geriatrik |
|---|---|
| Scheme | Karolinska Institutet Fonden Geriatrik |
| Role | Lead |
| Funding Start | 2015 |
| Funding Finish | 2016 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
Foundation Grant$6,700
Funding body: Gamla Tjänarinnor
| Funding body | Gamla Tjänarinnor |
|---|---|
| Scheme | Gamla Tjänarinnor |
| Role | Lead |
| Funding Start | 2015 |
| Funding Finish | 2016 |
| GNo | |
| Type Of Funding | International - Competitive |
| Category | 3IFA |
| UON | N |
Research Grant$1,600
Funding body: Stohnes Stiftelse
| Funding body | Stohnes Stiftelse |
|---|---|
| Scheme | Stohnes Stiftelse |
| Role | Lead |
| Funding Start | 2015 |
| Funding Finish | 2016 |
| GNo | |
| Type Of Funding | International - Non Competitive |
| Category | 3IFB |
| UON | N |
Research Collaborations
The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.
| Country | Count of Publications | |
|---|---|---|
| Australia | 9 | |
| Sweden | 4 | |
| United Kingdom | 2 | |
| United States | 2 | |
| Finland | 1 | |
| More... | ||
Dr Kirsten Coupland
Positions
Postdoctoral Researcher
Spratt Lab
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Casual Lecturer
Spratt Lab
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Focus area
Human Physiology
Contact Details
| kirsten.coupland@newcastle.edu.au | |
| Phone | (02) 49217402 |
| Mobile | +61 402 180 915 |
Office
| Room | MS-502 |
|---|---|
| Building | Medical Sciences Building |
| Location | Callaghan University Drive Callaghan, NSW 2308 Australia |
