Dr Kirsten Coupland

Dr Kirsten Coupland

Postdoctoral Researcher

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Dr. Kirsten Coupland is the inaugural Hunter Medical Research Institute Dalara Early Career Research Fellow. Dr. Coupland has spent her career understanding the molecular underpinnings of complex neurological disease, with the ultimate goal of identifying novel therapeutic targets. This research has taken her from understanding the epigenetic underpinnings of idiopathic neurodegenerative disease through to developing a pre-clinical immunotherapy capable of preventing aggregation of a protein involved in the pathogenesis of an inherited vascular dementia (CADASIL). Dr. Coupland was awarded her PhD from the University of New South Wales in 2015. Following a postdoctoral position at Karolinska Institutet, Sweden she was recruited to join the Translational Stroke Team at the University of Newcastle in 2018 where her molecular expertise is helping to understand how altered cerebrospinal fluid composition and dynamics impact on stroke outcome. Her work has garnered international attention having been invited to speak at several conferences, resulting in 10 publications (5 first author) and three awards. She is a founder and co-executive chair of the stroke coalition of preclinical researchers, an Australasian research body that provides a platform for collaboration and resource sharing among pre-clinical stroke research groups. When she isn’t doing research, Dr. Coupland is doing her best to imitate a pirate by living on a boat and drinking rum. She is yet to procure a parrot.


Qualifications

  • Doctor of Philosophy, University of New South Wales
  • Bachelor of Science (Honours), University of New South Wales
  • Diploma in Innovation Management, University of New South Wales

Keywords

  • Cerebrospinal fluid
  • Cerebrovasculature
  • Glymphatics
  • Neurodegeneration
  • Neuroscience
  • Stroke

Languages

  • English (Mother)

Fields of Research

Code Description Percentage
320199 Cardiovascular medicine and haematology not elsewhere classified 30
320899 Medical physiology not elsewhere classified 30
320903 Central nervous system 40

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Researcher University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
Casual Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
Postdoctoral Researcher University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
16/2/2015 - 27/4/2018 Postdoctoral Researcher Karolinska Institute
Neurobiology, Care Science and Society
Sweden
1/3/2010 - 23/12/2011 Research Assistant NeuRA
Ageing and Neurodegeneration
Australia

Awards

Prize

Year Award
2012 Junior Oral Presentation Prize
Prince of Wales Childrens Hospital
2012 Student Oral Presentation
Australasian GeneMappers Conference

Invitations

Participant

Year Title / Rationale
2015 Synthetic Biology Summer School

Speaker

Year Title / Rationale
2014 Commonwealth Science Conference
2013 Amplify Festival Brightsparks

Teaching

Code Course Role Duration
PHAR6704 Pharmacology of chronic conditions
School of Biomedical Sciences and Pharmacy
Lecturer 1/3/2021 - 25/6/2021
HUBS2407 Experimental design and laboratory skills in medical research
School of Biomedical Sciences and Pharmcy, The University of Newcastle
Lecturer 2/3/2020 - 26/6/2020
0000 Erasmus Internship
Karolinska Institute
In-lab supervisor 13/4/2015 - 14/9/2015
0000 Erasmus internship
Karolinska Institute
In-lab supervisor 4/9/2017 - 4/12/2017
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (10 outputs)

Year Citation Altmetrics Link
2021 Dzator JSA, Howe PRC, Griffiths LR, Coupland KG, Wong RHX, 'Cerebrovascular Function in Hormonal Migraine: An Exploratory Study', FRONTIERS IN NEUROLOGY, 12 (2021) [C1]
DOI 10.3389/fneur.2021.694980
Co-authors Peter Howe
2021 Omileke D, Bothwell S, Beard D, MacKovski N, Azarpeykan S, Coupland, et al., 'Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms', Jove-Journal of Visualized Experiments, (2021)
DOI 10.3791/62325
Co-authors Neil Spratt, Adjanie Patabendige, Daniel J Beard
2020 Hinwood M, Ilicic M, Gyawali P, Kluge MG, Coupland K, Smith A, et al., 'Exploration of stress management interventions to address psychological stress in stroke survivors: a protocol for a scoping review', BMJ OPEN, 10 (2020)
DOI 10.1136/bmjopen-2019-035592
Citations Scopus - 1Web of Science - 1
Co-authors Murielle Kluge, Rohan Walker, Michael Nilsson, Marina Ilicic, Madeleine Hinwood
2018 Panahi M, Mesri NY, Samuelsson E-B, Coupland KG, Forsell C, Graff C, et al., 'Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGF beta expression', JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 22 3016-3024 (2018)
DOI 10.1111/jcmm.13534
Citations Scopus - 7Web of Science - 5
2018 Coupland K, Lendahl U, Karlström H, 'Role of NOTCH3 mutations in the cerebral small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy', Stroke, 49 2793-2800 (2018)
DOI 10.1161/STROKEAHA.118.021560
Citations Scopus - 13Web of Science - 13
2016 Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease', PLOS ONE, 11 (2016)
DOI 10.1371/journal.pone.0157924
Citations Scopus - 38Web of Science - 37
2015 Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Effect of PSEN1 Mutations on MAPT Methylation in Early-Onset Alzheimer's Disease', CURRENT ALZHEIMER RESEARCH, 12 745-751 (2015)
DOI 10.2174/1567205012666150710110756
Citations Scopus - 6Web of Science - 7
2014 Coupland KG, Mellick GD, Silburn PA, Mather K, Armstrong NJ, Sachdev PS, et al., 'DNA Methylation of the MAPT Gene in Parkinson's Disease Cohorts and Modulation by Vitamin E In Vitro', MOVEMENT DISORDERS, 29 1606-1614 (2014)
DOI 10.1002/mds.25784
Citations Scopus - 58Web of Science - 54
2012 Zemb O, Lee M, Gutierrez-Zamora ML, Hamelin J, Coupland K, Hazrin-Chong NH, et al., 'Improvement of RNA-SIP by pyrosequencing to identify putative 4-n-nonylphenol degraders in activated sludge', WATER RESEARCH, 46 601-610 (2012)
DOI 10.1016/j.watres.2011.10.047
Citations Web of Science - 19
2010 Luty AA, Kwok JBJ, Dobson-Stone C, Loy CT, Coupland KG, Karlstrom H, et al., 'Sigma Nonopioid Intracellular Receptor 1 Mutations Cause Frontotemporal Lobar Degeneration-Motor Neuron Disease', ANNALS OF NEUROLOGY, 68 639-649 (2010)
DOI 10.1002/ana.22274
Citations Scopus - 148Web of Science - 143
Show 7 more journal articles

Conference (1 outputs)

Year Citation Altmetrics Link
2015 Kwok J, Coupland K, Mellick G, Mather K, Thalamuthu A, Armstrong N, et al., 'Genome-wide association study identifies the SLC2A14 gene on chromosome 12P13 as a trans-acting locus for methylation of MAPT gene', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015)
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Grants and Funding

Summary

Number of grants 18
Total funding $865,462

Click on a grant title below to expand the full details for that specific grant.


20213 grants / $14,300

The capacity of statins to improve stroke outcome: influence of perfusion lesion volume and collateral supply$10,000

Funding body: Priority Research Centre for Stroke and Brain Injury

Funding body Priority Research Centre for Stroke and Brain Injury
Project Team

Coupland K. G., Spratt N., Lillicrap T.

Scheme Strategic Investment Grant
Role Lead
Funding Start 2021
Funding Finish 2021
GNo
Type Of Funding Other Public Sector - Local
Category 2OPL
UON N

IBRO Meeting support$2,300

Funding body: International Brain Research Organization

Funding body International Brain Research Organization
Project Team

Coupland K.G., Rank M., Ong L. K., Hood R., Beard D.

Scheme IBRO meeting support
Role Lead
Funding Start 2021
Funding Finish 2022
GNo
Type Of Funding C3212 - International Not for profit
Category 3212
UON N

Cardiovascular Research Network Professional Development Award$2,000

Funding body: Cardiovascular Research Network

Funding body Cardiovascular Research Network
Project Team

Coupland K. G.

Scheme Professional Development Award
Role Lead
Funding Start 2021
Funding Finish 2021
GNo
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON N

20201 grants / $12,162

Mapping changes in cerebrospinal fluid composition after stroke to identify novel therapeutic targets for future drug discovery.$12,162

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Kirsten Coupland, Professor Neil Spratt, Doctor David Skerrett-Byrne
Scheme Research Grant
Role Lead
Funding Start 2020
Funding Finish 2020
GNo G2000282
Type Of Funding C3200 – Aust Not-for Profit
Category 3200
UON Y

20191 grants / $800

Travel grant$800

Funding body: NEWCASTLE UNIVERSITY

Funding body NEWCASTLE UNIVERSITY
Project Team

Coupland K. G.

Scheme Faculty of Health and Medicine Travel Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding C3200 – Aust Not-for Profit
Category 3200
UON N

20182 grants / $33,400

New tools to tackle familial vascular dementia$19,400

Funding body: Karolinska Institutet

Funding body Karolinska Institutet
Scheme Karolinska Institutet Forskningsbidrag
Role Lead
Funding Start 2018
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

New tools to tackle familial vascular dementia$14,000

Funding body: Karolinska Institutet

Funding body Karolinska Institutet
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2018
Funding Finish 2020
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20174 grants / $761,500

HMRI Early Career Research Fellowship in Stroke$712,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Neil Spratt, Doctor Kirsten Coupland
Scheme Project Grant
Role Investigator
Funding Start 2017
Funding Finish 2022
GNo G1701347
Type Of Funding C3300 – Aust Philanthropy
Category 3300
UON Y

Understanding the role of Notch3 in familial vascular dementia and its potential use in immunotherapies$21,000

Funding body: Karolinska Institutet Fonden Geriatrik

Funding body Karolinska Institutet Fonden Geriatrik
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$17,000

Funding body: Loo och Hans Ostermans

Funding body Loo och Hans Ostermans
Scheme Loo och Hans Ostermans
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Foundation Grant$11,000

Funding body: Gamla Tjänarinnor

Funding body Gamla Tjänarinnor
Scheme Gamla Tjänarinnor
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20164 grants / $20,000

Institutional grant$8,300

Funding body: Karolinska Institutet Fonden Geriatrik

Funding body Karolinska Institutet Fonden Geriatrik
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Foundation Grant$5,000

Funding body: Gamla Tjänarinnor

Funding body Gamla Tjänarinnor
Scheme Gamla Tjänarinnor
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$4,200

Funding body: Strokeförbundet

Funding body Strokeförbundet
Scheme Strokeförbundet
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$2,500

Funding body: Stohnes Stiftelse

Funding body Stohnes Stiftelse
Scheme Stohnes Stiftelse
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20153 grants / $23,300

Institutional grant$15,000

Funding body: Karolinska Institutet Fonden Geriatrik

Funding body Karolinska Institutet Fonden Geriatrik
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Foundation Grant$6,700

Funding body: Gamla Tjänarinnor

Funding body Gamla Tjänarinnor
Scheme Gamla Tjänarinnor
Role Lead
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$1,600

Funding body: Stohnes Stiftelse

Funding body Stohnes Stiftelse
Scheme Stohnes Stiftelse
Role Lead
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON N
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 9
Sweden 4
United Kingdom 2
United States 2
Finland 1
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Dr Kirsten Coupland

Positions

Postdoctoral Researcher
Spratt Lab
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Casual Lecturer
Spratt Lab
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Focus area

Human Physiology

Contact Details

Email kirsten.coupland@newcastle.edu.au
Phone (02) 49217402
Mobile +61 402 180 915

Office

Room MS-502
Building Medical Sciences Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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