Dr Kirsten Coupland

Dr Kirsten Coupland

Postdoctoral Researcher

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Dr. Kirsten Coupland is a postdoctoral researcher based at the Hunter Medical Research Institute (HMRI) and the University of Newcastle. Her current research examines the molecular basis of post-stroke outcomes, the results of which she aims to see implemented in a clinical setting.

Dr. Coupland was awarded her PhD from the University of New South Wales in 2015 for her work examining the expression of the microtubule associated protein tau (MAPT) gene in late-onset neurodegenerative disease and its association with disease risk and modifiable lifestyle factors. Under the supervision of Dr. Carol Dobson-Stone and A/Prof. John Kwok, Kirsten’s work identified multiple genetic factors with the potential to contribute to neurodegenerative disease risk. Her work led to the finding that increased DNA methylation (a modifiable epigenetic mark) of MAPT was associated with delayed onset of Parkinson’s disease, and that this methylation was modifiable by vitamin E. These findings led to two awards and an invitation by the Royal Society to present at the Commonwealth Science Conference in Bangalore, India.

Following her PhD, Kirsten took up a postdoctoral position at Karolsinka Institutet, Sweden in the lab of A/Prof Helena Karlström to examine the molecular underpinnings of an inherited vascular dementia (CADASIL). This condition arises due to mutations in a single gene (NOTCH3) and manifests as a series of small strokes that damage the brain and lead to memory impairment. This work focused on the development of a therapy that directs the immune system to remove a toxic build-up of protein in order to pre-emptively treat CADASIL. Her research at Karolinska Institutet resulted in the securing of several competitive grants that continue to fund this important work. In recognition of her skills and experience in neurodegenerative disease and vasculature, Kirsten was recruited to the labs of Prof. Neil Spratt and A/Prof Rohan Walker in May 2018 under the prestigious Dalara Foundation fellowship where she will investigate new targets for post-stroke therapy to improve patient outcomes.


Qualifications

  • Doctor of Philosophy, University of New South Wales
  • Bachelor of Science (Honours), University of New South Wales
  • Diploma in Innovation Management, University of New South Wales

Keywords

  • Cerebrovasculature
  • Epigenetics
  • Glymphatics
  • Neurodegeneration
  • Neuroscience
  • Stroke

Languages

  • English (Mother)

Fields of Research

Code Description Percentage
110999 Neurosciences not elsewhere classified 100

Professional Experience

UON Appointment

Title Organisation / Department

Academic appointment

Dates Title Organisation / Department
16/2/2015 - 27/4/2018 Postdoctoral Researcher Karolinska Institute
Neurobiology, Care Science and Society
Sweden
1/3/2010 - 23/12/2011 Research Assistant NeuRA
Ageing and Neurodegeneration
Australia

Awards

Prize

Year Award
2012 Junior Oral Presentation Prize
Prince of Wales Childrens Hospital
2012 Student Oral Presentation
Australasian GeneMappers Conference

Invitations

Participant

Year Title / Rationale
2015 Synthetic Biology Summer School

Speaker

Year Title / Rationale
2014 Commonwealth Science Conference
2013 Amplify Festival Brightsparks

Teaching

Code Course Role Duration
0000 Erasmus Internship
Karolinska Institute
In-lab supervisor 13/4/2015 - 14/9/2015
0000 Erasmus internship
Karolinska Institute
In-lab supervisor 4/9/2017 - 4/12/2017
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (8 outputs)

Year Citation Altmetrics Link
2020 Hinwood M, Ilicic M, Gyawali P, Kluge MG, Coupland K, Smith A, et al., 'Exploration of stress management interventions to address psychological stress in stroke survivors: A protocol for a scoping review', BMJ Open, 10 (2020)

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Several studies have sho... [more]

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Introduction Several studies have shown that stroke survivors report experiencing high and unremitting levels of stress, which can negatively affect brain repair processes and psychological outcomes and thereby compromise recovery. However, it is presently unclear which interventions have been trialled to manage stress in stroke survivors and whether they translate to clinically relevant outcomes. The aim of this scoping review will be to examine stress management interventions in stroke survivors in order to map the types of interventions trialled, commonly reported stress outcome measures and whether a reduction in stress contributes to reductions in relevant clinical outcomes. Methods and analysis The methodological framework described in Arksey and O'Malley will be applied to this review. A draft search strategy was developed in collaboration with an experienced senior health research librarian. A systematic search of Medline, Embase, CINAHL, Cochrane library, PsycInfo and Clinicaltrials.gov as well as hand searching of reference lists and reviews will identify relevant studies for inclusion. To be eligible for inclusion, studies must report on the outcomes of an intervention targeting stress management and resilience in stroke survivors. Study selection and critical appraisal of selected studies will be carried out independently by two authors, with discrepancies resolved by consensus. Data will be charted using a standard extraction form. Results will be tabulated and narratively summarised to highlight findings relevant to our research questions and to inform recommendations for future research. Ethics and dissemination This study does not require ethics approval. This scoping review will provide a synthesis of evidence for stress management interventions in stroke survivors. It will identify and clarify the gaps in stress research specific to stroke pathologies and highlight promising interventions for future research. Findings will be relevant to researchers and healthcare workers and will be disseminated via publications in peer-reviewed journals and presented at conferences.

DOI 10.1136/bmjopen-2019-035592
Co-authors Murielle Kluge, Madeleine Hinwood, Marina Ilicic, Michael Nilsson, Rohan Walker
2018 Panahi M, Mesri NY, Samuelsson E-B, Coupland KG, Forsell C, Graff C, et al., 'Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGF beta expression', JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 22 3016-3024 (2018)
DOI 10.1111/jcmm.13534
Citations Scopus - 4Web of Science - 4
2018 Coupland K, Lendahl U, Karlström H, 'Role of NOTCH3 mutations in the cerebral small vessel disease cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy', Stroke, 49 2793-2800 (2018)
DOI 10.1161/STROKEAHA.118.021560
Citations Scopus - 8
2016 Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease', PLOS ONE, 11 (2016)
DOI 10.1371/journal.pone.0157924
Citations Scopus - 23Web of Science - 22
2015 Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JBJ, 'Effect of PSEN1 Mutations on MAPT Methylation in Early-Onset Alzheimer's Disease', CURRENT ALZHEIMER RESEARCH, 12 745-751 (2015)
DOI 10.2174/1567205012666150710110756
Citations Scopus - 4Web of Science - 5
2014 Coupland KG, Mellick GD, Silburn PA, Mather K, Armstrong NJ, Sachdev PS, et al., 'DNA Methylation of the MAPT Gene in Parkinson's Disease Cohorts and Modulation by Vitamin E In Vitro', MOVEMENT DISORDERS, 29 1606-1614 (2014)
DOI 10.1002/mds.25784
Citations Scopus - 39Web of Science - 37
2012 Zemb O, Lee M, Gutierrez-Zamora ML, Hamelin J, Coupland K, Hazrin-Chong NH, et al., 'Improvement of RNA-SIP by pyrosequencing to identify putative 4-n-nonylphenol degraders in activated sludge', WATER RESEARCH, 46 601-610 (2012)
DOI 10.1016/j.watres.2011.10.047
Citations Scopus - 20Web of Science - 19
2010 Luty AA, Kwok JBJ, Dobson-Stone C, Loy CT, Coupland KG, Karlstrom H, et al., 'Sigma Nonopioid Intracellular Receptor 1 Mutations Cause Frontotemporal Lobar Degeneration-Motor Neuron Disease', ANNALS OF NEUROLOGY, 68 639-649 (2010)
DOI 10.1002/ana.22274
Citations Scopus - 126Web of Science - 119
Show 5 more journal articles

Conference (1 outputs)

Year Citation Altmetrics Link
2015 Kwok J, Coupland K, Mellick G, Mather K, Thalamuthu A, Armstrong N, et al., 'Genome-wide association study identifies the SLC2A14 gene on chromosome 12P13 as a trans-acting locus for methylation of MAPT gene', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015)
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Grants and Funding

Summary

Number of grants 14
Total funding $850,362

Click on a grant title below to expand the full details for that specific grant.


20201 grants / $12,162

Mapping changes in cerebrospinal fluid composition after stroke to identify novel therapeutic targets for future drug discovery.$12,162

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Kirsten Coupland, Professor Neil Spratt, Doctor David Skerrett-Byrne
Scheme Research Grant
Role Lead
Funding Start 2020
Funding Finish 2020
GNo G2000282
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

20182 grants / $33,400

New tools to tackle familial vascular dementia$19,400

Funding body: Karolinska Institutet

Funding body Karolinska Institutet
Scheme Karolinska Institutet Forskningsbidrag
Role Lead
Funding Start 2018
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

New tools to tackle familial vascular dementia$14,000

Funding body: Karolinska Institutet

Funding body Karolinska Institutet
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2018
Funding Finish 2020
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20174 grants / $761,500

HMRI Early Career Research Fellowship in Stroke$712,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Neil Spratt, Doctor Kirsten Coupland
Scheme Project Grant
Role Investigator
Funding Start 2017
Funding Finish 2022
GNo G1701347
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Understanding the role of Notch3 in familial vascular dementia and its potential use in immunotherapies$21,000

Funding body: Karolinska Institutet Fonden Geriatrik

Funding body Karolinska Institutet Fonden Geriatrik
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$17,000

Funding body: Loo och Hans Ostermans

Funding body Loo och Hans Ostermans
Scheme Loo och Hans Ostermans
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Foundation Grant$11,000

Funding body: Gamla Tjänarinnor

Funding body Gamla Tjänarinnor
Scheme Gamla Tjänarinnor
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20164 grants / $20,000

Institutional grant$8,300

Funding body: Karolinska Institutet Fonden Geriatrik

Funding body Karolinska Institutet Fonden Geriatrik
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Foundation Grant$5,000

Funding body: Gamla Tjänarinnor

Funding body Gamla Tjänarinnor
Scheme Gamla Tjänarinnor
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$4,200

Funding body: Strokeförbundet

Funding body Strokeförbundet
Scheme Strokeförbundet
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$2,500

Funding body: Stohnes Stiftelse

Funding body Stohnes Stiftelse
Scheme Stohnes Stiftelse
Role Lead
Funding Start 2016
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20153 grants / $23,300

Institutional grant$15,000

Funding body: Karolinska Institutet Fonden Geriatrik

Funding body Karolinska Institutet Fonden Geriatrik
Scheme Karolinska Institutet Fonden Geriatrik
Role Lead
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Foundation Grant$6,700

Funding body: Gamla Tjänarinnor

Funding body Gamla Tjänarinnor
Scheme Gamla Tjänarinnor
Role Lead
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Research Grant$1,600

Funding body: Stohnes Stiftelse

Funding body Stohnes Stiftelse
Scheme Stohnes Stiftelse
Role Lead
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Non Competitive
Category 3IFB
UON N
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 7
Sweden 4
United States 2
Finland 1
United Kingdom 1
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Dr Kirsten Coupland

Position

Postdoctoral Researcher
Spratt Lab
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Human Physiology

Contact Details

Email kirsten.coupland@newcastle.edu.au
Phone (02) 4921 16903
Mobile +61 402 180 915

Office

Room MS-502
Building Medical Sciences Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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