
Dr Daniel Beard
Research Fellow
School of Biomedical Sciences and Pharmacy (Human Physiology)
- Email:daniel.j.beard@newcastle.edu.au
- Phone:(02) 4921 7402
Career Summary
Biography
Dr Daniel Beard completed his PhD (Human Physiology) in 2015 in the Translational Stroke Laboratory of Professor Neil Spratt at the University of Newcastle, Australia. His PhD thesis investigated the mechanisms regulating collateral blood flow after stroke. He found that changes in intracranial pressure (ICP) profoundly reduced collateral blood flow to the ischaemic brain during stroke. This work generated the novel hypothesis, that changes in ICP in human stroke may be the cause of the previously identified, but poorly understood phenomenon of collateral vessel failure and neurological deterioration in a subset of stroke patients. This work provided the stimulus for clinical investigations to the test this novel hypothesis.
In September 2016, Daniel was awarded a highly competitive postdoctoral fellowship in the laboratory of Professor Alastair Buchan, the Professor of Stroke Medicine and Pro-Vice Chancellor at the University of Oxford to work on a MRC UK funded project investigating the role of mammalian target of rapamycin mTOR in neurovascular dysfunction after stroke. In this role he continued to research the important role of the cerebral vasculature in determining stroke outcome. Specifically, he focused on targeting the mTOR pathway to protect the cells that make up the capillaries of the brain as a means of improving microvascular perfusion, reducing blood brain barrier disruption and ultimately improving neurological outcome after stroke. Adjacent to this work he received a prestigious EMBO short-term fellowship and grant funding from the Berlin Institute of Health to visit the Charité Universitätsmedizin in Berlin to establish a UK-European collaboration to investigate the role of the mTOR pathway in hypothermic neuroprotection in stroke. This project also served as a foundation to create a joint programme on neurovascular protection in stroke, as well as further foster the collaboration of the Charité with Oxford University. Daniel is continuing to collaborate with the scientists at Charite’ to continue this work.
As well as his research pursuits, Daniel continued to develop his expertise as a university educator. While at Oxford he was appointed as a Lecturer in Medicine at Corpus Christi College and a Tutor in Physiology at Harris Manchester College. He also completed the Enhancing Teaching Programme in Sciences, a programme designed to support academic and research staff across the Medical Science Division who teach at Oxford to help improve their teaching and thus enhance their students’ learning experiences.
Daniel was recently awarded an NHMRC Ideas Grant and has returned to the University of Newcastle as a lecturer to investigate novel therapies to enhance collateral blood flow after stroke.
Qualifications
- Doctor of Philosophy, University of Newcastle
- Bachelor of Biomedical Sciences, University of Newcastle
- Bachelor of Biomedical Sciences (Hons), University of Newcastle
Keywords
- Autonomic Nervous System
- Brain Cytoprotection
- Cardiovascular Physiology
- Cell Culture
- Cerebrospinal Fluid
- Collaterals
- Computed Tomography Perfusion Imaging
- Flow Cytometry
- Higher Education Teaching
- Hypothermia
- Immunohistochemistry
- Intracerebral Haemorrhage
- Intracranial Pressure
- Stress
- Stroke
- Systematic Review and Meta-analysis
Professional Experience
UON Appointment
Title | Organisation / Department |
---|---|
Research Fellow | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Research Fellow | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Academic appointment
Dates | Title | Organisation / Department |
---|---|---|
7/12/2009 - 25/6/2010 | Research Assistant- Centre for Information Based Medicine Laboratory | School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle Australia |
5/7/2010 - 28/1/2011 | Research Assistant- Translational Stroke Laboratory | School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle Australia |
27/8/2015 - 26/8/2016 | Postdoctoral Researcher - Translational Stroke Laboratory | Discipline of Human Physiology, School of Biomedical Sciences and Pharmacy, Faculty of health and Medicine, University of Newcastle Australia |
26/9/2016 - 31/10/2019 | Postdoctoral Scientist in Acute Stroke - Laboratory of Cerebral Ischaemia | University of Oxford Radcliffe Department of Medicine United Kingdom |
Teaching appointment
Dates | Title | Organisation / Department |
---|---|---|
5/2/2007 - 26/6/2015 | Casual Academic | School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle Australia |
4/9/2017 - 8/3/2019 | Lecturer in Medicine | Corpus Christi College, University of Oxford United Kingdom |
4/9/2017 - 8/3/2019 | Tutor in Physiology | Harris Manchester College, University of Oxford United Kingdom |
Awards
Award
Year | Award |
---|---|
2018 |
Guarantors of Brain Sponsorship Award for Short Meeting and Conferences: 8th Annual UK & Ireland Early Career Blood Brain Barrier Symposium, 30th of November 2018, Oxford. University of Oxford |
Distinction
Year | Award |
---|---|
2009 |
University Medal School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
Prize
Year | Award |
---|---|
2019 |
ISCBFM Early Career Investigator Travel Grant to attend the 29th International Symposium on Cerebral Blood Flow Metabolism and Function, Yokohama, Japan, 4-7th of July, 2019. University of Oxford |
2018 |
Guarantors of Brain Travel Grant to attend the 11th World Stroke Congress in Montreal, Canada. October 17-20, 2018 University of Oxford |
2018 |
Oxford Berlin Summer School Travel Grant University of Oxford |
2015 |
ISCBFM Young Investigator Travel Grant to attend the 27th International Symposium on Cerebral Blood Flow, Metabolism and Function, Vancouver, Canada, 27 to 30th June, 2015. School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
2012 |
3rd place in the University of Newcastle Three Minute Thesis Final School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
2009 |
Biorad Prize for Biomedical Science School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
2009 |
ADInstruments Prize for Human Structure and Function School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
2009 |
Biosystems Prize for Cellular and Molecular Science School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
Research Award
Year | Award |
---|---|
2015 |
School of Biomedical Sciences and Pharmacy Early Career Researcher Paper of the Month School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
2013 |
Best student presentation, Kioloa Neuroscience Colloquium 2013 School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
Scholarship
Year | Award |
---|---|
2011 |
Australian Postgraduate Award, University of Newcastle School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
2008 |
Biomedical Science Summer Vacation Scholarship School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
2007 |
University of Newcastle Summer Vacation Scholarship School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle |
Invitations
Committee Member
Year | Title / Rationale |
---|---|
2019 | Chair of the International Society of Cerebral Blood Flow and Metabolism Early Career Investigator Committee - Brain 2021 |
2018 | Founder and Chair of the Radcliffe Department of Medicine Researcher Association Committee |
2018 | International Society of Cerebral Blood Flow and Metabolism Early Career Investigator Committee - Brain 2019 |
2017 | Organizing committee for the 8th Annual UK & Ireland Early Career Blood Brain Barrier Symposium |
2017 | Postdoctoral Representative on the Radcliffe Department of Medicine Career Development Committee |
Panel Participant
Year | Title / Rationale |
---|---|
2018 | Radcliffe Department of Medicine Award for Excellent Supervision Selection Panel |
2017 | Accelerated Medical Course interview panel, Harris Manchester College, University of Oxford |
Peer Reviewer
Year | Title / Rationale |
---|---|
2015 | Hunter Medical Research Institute and Hunter Children’s Research Foundation Project Grant Review Panel. |
Teaching
Code | Course | Role | Duration |
---|---|---|---|
HUBS 1107 |
Neuroscience and Head and Neck Anatomy Faculty of Health, University of Newcastle Lab demonstrator |
Casual Academic | 1/7/2014 - 1/11/2014 |
MEDI 1015 |
Medical Science 1 Faculty of Health, University of Newcastle Lab demonstrator |
Casual Academic | 1/3/2009 - 31/5/2015 |
HUBS 3403 |
Neuroscience Faculty of Health, University of Newcastle Lab demonstrator |
Casual Academic | 1/3/2015 - 31/5/2015 |
MEDI 3018 |
General Practice and Subspecialties 2 Faculty of Health, University of Newcastle Lab demonstrator |
Casual Academic | 1/3/2009 - 31/5/2015 |
HUBS 1403 |
Biomedical Science Part 1 Faculty of Health, University of Newcastle PASS Leader |
PASS Leader | 1/3/2007 - 1/11/2008 |
MEDI 2014 |
Medical Science 3 Faculty of Health, University of Newcastle Lab demonstrator |
Casual Academic | 1/3/2009 - 31/5/2015 |
HUBS 2105 |
Sports Science 2 Faculty of Health, University of Newcastle Lab Demonstrator |
Casual Academic | 1/3/2009 - 31/5/2012 |
HUBS1401 |
Human Biosciences Faculty of Health, University of Newcastle Casual tutor and lecturer. |
Casual Academic | 1/3/2009 - 31/5/2015 |
BC98 |
Integrative Systems Physiology for Biomedical Science Corpus Christi College, University of Oxford |
Tutor | 4/9/2017 - 8/3/2019 |
HUBS 1404 |
Biomedical Science Part 2 Faculty of Health, University of Newcastle PASS Leader |
PASS Leader | 1/3/2007 - 1/11/2008 |
HUBS2507 |
Integrative Physiology for Biomedical Science The University of Newcastle |
Lecturer | 27/7/2020 - 30/11/2020 |
HUBS2505 |
Human Pathophysiology Universtiy of Newcastle |
Lecturer | 2/3/2020 - 30/6/2020 |
HUBS 1105 |
Musculoskeletal Anatomy Faculty of Health, University of Newcastle Lab Demonstrator |
Casual Academic | 1/3/2014 - 31/5/2015 |
A101 |
Physiology for Graduate Entry Medicine Harris Manchester College, University of Oxford |
Tutor | 4/9/2017 - 8/3/2019 |
HUBS 2103 |
Neural and Visceral Anatomy Faculty of Health, University of Newcastle Lab demonstrator |
Casual Academic | 1/3/2015 - 31/5/2015 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (17 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2021 |
Omileke D, Bothwell S, Beard D, MacKovski N, Azarpeykan S, Coupland, et al., 'Short-Duration Hypothermia Induction in Rats using
Models for Studies examining Clinical Relevance and
Mechanisms', Jove-Journal of Visualized Experiments, (2021)
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2020 |
Beard DJ, Li Z, Schneider AM, Couch Y, Cipolla MJ, Buchan AM, 'Rapamycin Induces an eNOS (Endothelial Nitric Oxide Synthase) Dependent Increase in Brain Collateral Perfusion in Wistar and Spontaneously Hypertensive Rats', Stroke, 2834-2843 (2020) [C1] Background and Purpose: Rapamycin is a clinically approved mammalian target of rapamycin inhibitor that has been shown to be neuroprotective in animal models of stroke. However, t... [more] Background and Purpose: Rapamycin is a clinically approved mammalian target of rapamycin inhibitor that has been shown to be neuroprotective in animal models of stroke. However, the mechanism of rapamycin-induced neuroprotection is still being explored. Our aims were to determine if rapamycin improved leptomeningeal collateral perfusion, to determine if this is through eNOS (endothelial nitric oxide synthase)-mediated vessel dilation and to determine if rapamycin increases immediate postreperfusion blood flow. Methods: Wistar and spontaneously hypertensive rats (¿14 weeks old, n=22 and n=15, respectively) were subjected to ischemia by middle cerebral artery occlusion (90 and 120 minutes, respectively) with or without treatment with rapamycin at 30-minute poststroke. Changes in middle cerebral artery and collateral perfusion territories were measured by dual-site laser Doppler. Reactivity to rapamycin was studied using isolated and pressurized leptomeningeal anastomoses. Brain injury was measured histologically or with triphenyltetrazolium chloride staining. Results: In Wistar rats, rapamycin increased collateral perfusion (43±17%), increased reperfusion cerebral blood flow (16±8%) and significantly reduced infarct volume (35±6 versus 63±8 mm , P<0.05). Rapamycin dilated leptomeningeal anastomoses by 80±9%, which was abolished by nitric oxide synthase inhibition. In spontaneously hypertensive rats, rapamycin increased collateral perfusion by 32±25%, reperfusion cerebral blood flow by 44±16%, without reducing acute infarct volume 2 hours postreperfusion. Reperfusion cerebral blood flow was a stronger predictor of brain damage than collateral perfusion in both Wistar and spontaneously hypertensive rats. Conclusions: Rapamycin increased collateral perfusion and reperfusion cerebral blood flow in both Wistar and comorbid spontaneously hypertensive rats that appeared to be mediated by enhancing eNOS activation. These findings suggest that rapamycin may be an effective acute therapy for increasing collateral flow and as an adjunct therapy to thrombolysis or thrombectomy to improve reperfusion blood flow. 3
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2020 |
Beard DJ, Brown LS, Sutherland BA, 'The rise of pericytes in neurovascular research', Journal of Cerebral Blood Flow & Metabolism, 40 2366-2373 (2020)
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2016 |
Beard DJ, Murtha LA, McLeod DD, Spratt NJ, 'Intracranial Pressure and Collateral Blood Flow', Stroke, 47 1695-1700 (2016) [C1]
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2016 |
Beard DJ, Logan CL, McLeod DD, Hood RJ, Pepperall D, Murtha LA, Spratt NJ, 'Ischemic penumbra as a trigger for intracranial pressure rise - A potential cause for collateral failure and infarct progression?', J Cereb Blood Flow Metab, 36 917-927 (2016) [C1]
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2016 |
Murtha LA, Beard DJ, Bourke JT, Pepperall D, McLeod DD, Spratt NJ, 'Intracranial Pressure Elevation 24 h after Ischemic Stroke in Aged Rats Is Prevented by Early, Short Hypothermia Treatment.', Front Aging Neurosci, 8 124 (2016) [C1]
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2015 |
Murtha LA, McLeod DD, Pepperall D, McCann SK, Beard DJ, Tomkins AJ, et al., 'Intracranial pressure elevation after ischemic stroke in rats: Cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy', Journal of Cerebral Blood Flow and Metabolism, 35 592-600 (2015) [C1] In both the human and animal literature, it has largely been assumed that edema is the primary cause of intracranial pressure (ICP) elevation after stroke and that more edema equa... [more] In both the human and animal literature, it has largely been assumed that edema is the primary cause of intracranial pressure (ICP) elevation after stroke and that more edema equates to higher ICP. We recently demonstrated a dramatic ICP elevation 24 hours after small ischemic strokes in rats, with minimal edema. This ICP elevation was completely prevented by short-duration moderate hypothermia soon after stroke. Here, our aims were to determine the importance of edema in ICP elevation after stroke and whether mild hypothermia could prevent the ICP rise. Experimental stroke was performed in rats. ICP was monitored and short-duration mild (35 °C) or moderate (32.5 °C) hypothermia, or normothermia (37 °C) was induced after stroke onset. Edema was measured in three studies, using wet-dry weight calculations, T 2-weighted magnetic resonance imaging, or histology. ICP increased 24 hours after stroke onset in all normothermic animals. Short-duration mild or moderate hypothermia prevented this rise. No correlation was seen between ¿ICP and edema or infarct volumes. Calculated rates of edema growth were orders of magnitude less than normal cerebrospinal fluid production rates. These data challenge current concepts and suggest that factors other than cerebral edema are the primary cause of the ICP elevation 24 hours after stroke onset.
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2015 |
Beard DJ, Mcleod DD, Logan CL, Murtha LA, Imtiaz MS, Van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 35 861-872 (2015) [C1] Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite st... [more] Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite stable arterial occlusion. The cause for 'collateral failure' is unknown. We recently showed that intracranial pressure (ICP) rises dramatically but transiently 24 hours after even minor experimental stroke. We hypothesized that ICP elevation would reduce collateral blood flow. First, we investigated the regulation of flow through collateral vessels and the penetrating arterioles arising from them during stroke reperfusion. Wistar rats were subjected to intraluminal middle cerebral artery (MCA) occlusion (MCAo). Individual pial collateral and associated penetrating arteriole blood flow was quantified using fluorescent microspheres. Baseline bidirectional flow changed to MCA-directed flow and increased by >450% immediately after MCAo. Collateral diameter changed minimally. Second, we determined the effect of ICP elevation on collateral and watershed penetrating arteriole flow. Intracranial pressure was artificially raised in stepwise increments during MCAo. The ICP increase was strongly correlated with collateral and penetrating arteriole flow reductions. Changes in collateral flow post-stroke appear to be primarily driven by the pressure drop across the collateral vessel, not vessel diameter. The ICP elevation reduces cerebral perfusion pressure and collateral flow, and is the possible explanation for 'collateral failure' in stroke-in-progression.
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2014 |
Beard DJ, McLeod DD, Murtha LA, Spratt NJ, 'Elevation of intracranial pressure reduces leptomeningeal collateral and watershed blood flow during experimental stroke', CEREBROVASCULAR DISEASES, 37 65-65 (2014)
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2014 |
Murtha LA, McLeod DD, Beard DJ, Pepperall DG, Spratt NJ, 'Short duration mild hypothermia prevents delayed intracranial pressure rise following experimental ischaemic stroke', CEREBROVASCULAR DISEASES, 37 340-340 (2014)
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2014 |
Murtha LA, Yang Q, Parsons MW, Levi CR, Beard DJ, Spratt NJ, McLeod DD, 'Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats', Fluids and Barriers of the CNS, 11 (2014) [C1] Background: Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the... [more] Background: Many aspects of CSF dynamics are poorly understood due to the difficulties involved in quantification and visualization. In particular, there is debate surrounding the route of CSF drainage. Our aim was to quantify CSF flow, volume, and drainage route dynamics in vivo in young and aged spontaneously hypertensive rats (SHR) using a novel contrast-enhanced computed tomography (CT) method.Methods: ICP was recorded in young (2-5 months) and aged (16 months) SHR. Contrast was administered into the lateral ventricles bilaterally and sequential CT imaging was used to visualize the entire intracranial CSF system and CSF drainage routes. A customized contrast decay software module was used to quantify CSF flow at multiple locations.Results: ICP was significantly higher in aged rats than in young rats (11.52 ± 2.36 mmHg, versus 7.04 ± 2.89 mmHg, p = 0.03). Contrast was observed throughout the entire intracranial CSF system and was seen to enter the spinal canal and cross the cribriform plate into the olfactory mucosa within 9.1 ± 6.1 and 22.2 ± 7.1 minutes, respectively. No contrast was observed adjacent to the sagittal sinus. There were no significant differences between young and aged rats in either contrast distribution times or CSF flow rates. Mean flow rates (combined young and aged) were 3.0 ± 1.5 µL/min at the cerebral aqueduct; 3.5 ± 1.4 µL/min at the 3rd ventric= and 2.8 ± 0.9 µL/min at the 4th ventricle. Intracranial CSF volumes (and as percentage total brain volume) were 204 ± 97 µL (8.8 ± 4.3%) in the young and 275 ± 35 µL (10.8 ± 1.9%) in the aged animals (NS).Conclusions: We have demonstrated a contrast-enhanced CT technique for measuring and visualising CSF dynamics in vivo. These results indicate substantial drainage of CSF via spinal and olfactory routes, but there was little evidence of drainage via sagittal sinus arachnoid granulations in either young or aged animals. The data suggests that spinal and olfactory routes are the primary routes of CSF drainage and that sagittal sinus arachnoid granulations play a minor role, even in aged rats with higher ICP. © 2014 Murtha et al.; licensee BioMed Central Ltd.
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2013 |
Bobrovskaya L, Beard D, Bondarenko E, Beig MI, Jobling P, Walker FR, et al., 'Does exposure to chronic stress influence blood pressure in rats?', AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 177 217-223 (2013) [C1]
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2013 |
McLeod DD, Beard DJ, Parsons MW, Levi CR, Calford MB, Spratt NJ, 'Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model', PLOS ONE, 8 (2013) [C1]
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Show 14 more journal articles |
Conference (13 outputs)
Year | Citation | Altmetrics | Link | ||
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2020 | Schneider AM, Beard D, Buchan A, 'Rapamycin Improves Post-Recanalization Blood Flow After Acute Experimental Stroke in Rats', STROKE, Los Angeles, CA (2020) | ||||
2019 | Beard DJ, Couch Y, Li Z, Cipolla MJ, Buchan AM, 'Rapamycin induces an eNOS dependent increase in brain collateral perfusion after acute experimental stroke in rats', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Yokohama, JAPAN (2019) | ||||
2018 | Beard D, Hadley G, Thurley N, Howells D, Sutherland B, Buchan A, 'THE EFFECT OF RAPAMYCIN TREATMENT ON CEREBRAL ISCHEMIA: A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANIMAL MODELS', INTERNATIONAL JOURNAL OF STROKE (2018) | ||||
2013 |
Beard D, McLeod D, Spratt N, 'The collateral circulation: key to outcome in mice and men', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
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2012 |
Beard DJ, McLeod DD, Imtiaz MS, Spratt NJ, 'Quantitative assessment of leptomeningeal collateral flow in experimental stroke', The Stroke Interventionalist, Los Angeles, CA (2012) [E3]
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2012 |
McLeod DD, Beard DJ, Imtiaz MS, Spratt NJ, 'Validating a novel method for measuring leptomeningeal collateral flow in experimental stroke', The Stroke Interventionalist, Los Angeles, CA (2012) [E3]
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Show 10 more conferences |
Other (1 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2015 |
Murtha LA, Mcleod DD, Pepperall D, Mccann SK, Beard DJ, Tomkins AJ, et al., 'Erratum: Intracranial pressure elevation after ischemic stroke in rats: Cerebral edema is not the only cause, and short-duration mild hypothermia is a highly effective preventive therapy (Journal of Cerebral Blood Flow & Metabolism (2015) 35 (592-600) DOI: 10.1038/jcbfm.2014.230)', ( issue.12 pp.2109) (2015) [O1]
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Grants and Funding
Summary
Number of grants | 7 |
---|---|
Total funding | $479,222 |
Click on a grant title below to expand the full details for that specific grant.
20201 grants / $5,000
Laser Speckle Contrast Imager (LSCI) for imaging of perfusion in cerebral and peripheral vasculature in experimental models of Stroke and Peripheral Vascular Disease (PVD)$5,000
Funding body: School of Biomedical Sciences and Pharmacy
Funding body | School of Biomedical Sciences and Pharmacy |
---|---|
Project Team | Daniel Beard, Neil Spratt, Michael Bourke |
Scheme | SBSP Equipment Grant |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2020 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20193 grants / $134,000
Neuroprotection: Is the mechanism of hypothermic neuroprotection explained by hamartin's effects on mTOR? $113,500
Funding body: Berlin Institute of Health
Funding body | Berlin Institute of Health |
---|---|
Project Team | Alastair Buchan, Daniel Beard, Philipp Mergenthaler, Ulrich Dirnagl, Matthias Endres, Gabriele De Luca and Bryan Adriaanse. |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2019 |
Funding Finish | 2020 |
GNo | |
Type Of Funding | C3232 - International Govt - Other |
Category | 3232 |
UON | N |
Investigating the role of hamartin in hypothermic neuroprotection in ischaemic stroke$10,500
Funding body: John Fell Fund - University of Oxford
Funding body | John Fell Fund - University of Oxford |
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Project Team | Alastair Buchan, Daniel Beard, Gabriele De Luca, Bryan Adriaanse, Yvonne Couch |
Scheme | Small Grant Funding Scheme |
Role | Investigator |
Funding Start | 2019 |
Funding Finish | 2020 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
EMBO Short-term Fellowship $10,000
Funding body: European Molecular Biology Organization
Funding body | European Molecular Biology Organization |
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Project Team | Daniel Beard, Philipp Mergenthaler and Alastair Buchan |
Scheme | Short-term Fellowship Scheme |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
20153 grants / $340,222
A new understanding of increased pressure within the skull in brain diseases$300,000
Funding body: Brain Foundation (NSW Branch)
Funding body | Brain Foundation (NSW Branch) |
---|---|
Project Team | Professor Neil Spratt, Doctor Damian McLeod, Doctor Lucy Murtha, Doctor Daniel Beard |
Scheme | Major Research Gift Initiative |
Role | Investigator |
Funding Start | 2015 |
Funding Finish | 2017 |
GNo | G1501106 |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | Y |
Stroke In Progression: a new understanding of pathophysiology opening the door to effective therapy$25,222
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Doctor Ferdinand Miteff, Doctor Damian McLeod, Doctor Daniel Beard, Doctor Lucy Murtha, Professor Neil Spratt |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2015 |
Funding Finish | 2015 |
GNo | G1500830 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
A better understanding of intracranial pressure changes after brain injury$15,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Neil Spratt, Doctor Damian McLeod, Doctor Lucy Murtha, Doctor Daniel Beard |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2015 |
Funding Finish | 2017 |
GNo | G1500709 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2019 | PhD | Elucidating the Mechanisms Involved in Intracranial Pressure Elevation and Hypothermia Treatment for Ischaemic Stroke | PhD (Human Physiology), College of Health, Medicine and Wellbeing, The University of Newcastle | Consultant Supervisor |
2019 | PhD | The metabolic effects of mTOR inhibition in stroke | Biol Sc Not Elsewhere Classifd, University of Oxford | Co-Supervisor |
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2019 | Honours | Immunohistochemical Analysis of the Mammalian Target of Rapamycin Pathway in Human Hippocampi from Patients with Drug-Resistant Epilepsy | Biol Sc Not Elsewhere Classifd, Oxford University, UK | Principal Supervisor |
2019 | Honours | Analysis of the Mechanistic Target of Rapamycin (mTOR) Pathway in the Human Cerebral Cortex after Ischaemic Stroke | Biol Sc Not Elsewhere Classifd, University of Oxford | Principal Supervisor |
2018 | Honours | Investigating the Endogenous Neuroprotective Properties of Hamartin in Experimental Stroke | Biol Sc Not Elsewhere Classifd, Oxford University, UK | Principal Supervisor |
News
NHMRC awards $9.3 million to 13 University of Newcastle projects
December 18, 2019
Dr Daniel Beard
Position
Research Fellow
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Focus area
Human Physiology
Contact Details
daniel.j.beard@newcastle.edu.au | |
Phone | (02) 4921 7402 |
Fax | (02) 4921 7903 |
Link |
Office
Room | MS508 |
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Building | Medical Sciences |
Location | Callaghan University Drive Callaghan, NSW 2308 Australia |