The University of Newcastle, Australia
Available in 2019

Course handbook


Presents the pathophysiology of altered health states and their management including both pharmacological and non-pharmacological interventions. Specific conditions covered in this course include cardiovascular and renal disease. The course considers aspects of pharmacy practice including a systematic review of prescription and non-prescription medications and Complementary and Alternate Medicines, which will address the quality use of medicines in the treatment of these conditions.

Pharmacokinetic considerations in conditions of the cardiovascular and renal system are covered including pharmacokinetic modelling: volume of distribution and protein binding and renal clearance. An introduction to dose regimen design and therapeutic drug monitoring will also be covered.

Application of the knowledge developed in this course will be complemented by clinical skills training.

Availability2019 Course Timetables


  • Semester 1 - 2019

Learning outcomes

On successful completion of the course students will be able to:

1. Describe the pathophysiology and management of cardiovascular and renal disease.

2. Gain an understanding of the signs, symptoms and complications of common infections affecting the cardiovascular system including endocarditis, be aware of the pathogens involved, understand relevant diagnostic tests and be aware of first and second line anti-infective therapy as well as non-pharmacological approaches to the management of these conditions.

3. Describe the pathophysiology and basic management principles of anaemia as a result of renal impairment.

4. Describe the quality use of medicines' issues surrounding these therapeutic agents in the treatment of these conditions and continue to develop clinical skills and communication skills in the therapeutic management of these conditions.

5. Describe the role of pharmacodynamics and pharmacokinetic factors as determinants of drug response in cardiovascular and renal conditions.

6. Understand the underlying principles of pharmacokinetic modelling; volume of distribution and protein binding; renal clearance; and basic underlying principles of dose regimen design and therapeutic drug monitoring.


1. This course will cover the pathophysiology, therapeutic treatment and pharmacy practice issues in the management of:

- Cardiovascular conditions (including hypertension, heart failure, angina, arrhythmias, clotting disorders, stroke).

-  Renal disease.

-  Anaemia of renal impairment.

-  The pathophysiology and principles for the treatment of Endocarditis.

2. The concept of minor illness and major disease will be discussed, including the use of prescription and non-prescription products, including Complementary and Alternate Medicines. Non-pharmacological approaches to the management of these conditions will also be discussed.

3. The course covers all pharmacokinetic considerations for therapeutic agents used in the management of cardiovascular and renal conditions including:

-  Pharmacokinetic modelling.

-  Volume of distribution and protein binding.

-  Clearance of substances by the kidney.

-  Principles underlying dose regimen design.

-  Application of therapeutic drug monitoring in the therapeutic management of patients.


This course is only available to students enrolled in the Bachelor of Pharmacy (Honours) program.

Pre-requisite - successful completion of PHAR1101 and PHAR1201

Assumed knowledge

PHAR1101 Introduction to Pharmacy and Formulation Sciences 1 and PHAR1201 Introduction to Pharmacy and Formulation Sciences 2, HUBS1403 Human Bioscience Part 1 and HUBS1404 Human Bioscience Part 2

Assessment items

Formal Examination: Written exam *

In Term Test: Examination Class

In Term Test: Tutorial Quiz

* This assessment has a compulsory requirement.

Compulsory Requirements

In order to pass this course, each student must complete ALL of the following compulsory requirements:

General Course Requirements:

  • Tutorial: Attendance Requirement - Students must attend a minimum number of these sessions. - Students must attend all tutorial sessions unless a valid reason is provided.

Course Assessment Requirements:

  • Formal Examination: Pass Requirement - Students must pass this assessment item to pass the course.

Contact hours



Face to Face On Campus 38 hour(s) per Term Full Term

3 hr per week for 12 weeks and an in term examination


Face to Face On Campus 2 hour(s) per Week for 10 Weeks