
Professor Eileen McLaughlin
Conjoint Professor
School of Environmental and Life Sciences (Biological Sciences)
- Email:eileen.mclaughlin@newcastle.edu.au
- Phone:(02) 4921 5708
A good egg
The mysteries of conception are this researcher's passion. As a young biologist, Professor Eileen McLaughlin produced her first test tube baby in 1983, just five years after Louise Brown was heralded as the world's first IVF birth.
It was a case of 'right time, right place' for McLaughlin, who graduated from the University of Glasgow to research positions involving assisted reproduction at the universities of Birmingham and Bristol at a time when Britain was the international hot spot in this emerging field.
That experience was the foundation for what has become a distinguished research career in reproductive science. McLaughlin's work has been recognised with awards from the British Fertility Society and the Society for Reproductive Biology in Australia and has been published in esteemed medical journals including Cell and The Lancet.
Since joining the University's reproductive science group in 2001, a focus of McLaughlin's research has been the fertility prospects of older women.
She says her research has reinforced the theory that declining egg quality, rather than quantity, is the major hindrance to conception in women in their late 30s and older.
While science has not delivered a magic formula to improve the quality of mature eggs, McLaughlin is researching the way oocytes, or immature egg cells, are 'woken' to be released from the ovary. The aim is that better understanding this process could lead to new ways of harvesting or prolonging the life of good eggs.
"The attrition rate of eggs is very high," she says. "A female has about 1 million eggs at birth but by the time she is in her mid 30s she is down to about 20,000. By the age of 40, she will have a few thousand," she says.
"She will only ovulate 400 eggs in her life, so the vast majority of them are wasted. The challenge is to find a way to a hold on to some of those good eggs longer."
McLaughlin's work has established that many chemicals used in everyday items such as glues, dyes and pesticides, are potentially toxic to eggs, which can further frustrate the efforts of older mothers to conceive.
"There are increasing numbers of women in their 30s who are having difficulty producing a sufficient number of good eggs to conceive. The evidence suggests that this may be influenced by lifetime exposure, probably at very low levels, to environmental toxicants," she says.
Exposure to these chemicals is a consequence of living in the modern world and McLaughlin says little can be done to reduce women's susceptibility. But the research underpins the importance of her work in trying to extend the life of healthy oocytes and improve outcomes for couples trying to conceive later in life.
Professor Eileen McLaughlin researches in collaboration with the Hunter Medical Research Institute's (HMRI) Pregnancy and Reproduction Program. HMRI is a partnership between the University, Hunter New England Local Health District and the community.
Visit the Centre for Reproductive Science website
Visit the HMRI website
A good egg
Biologist Professor Eileen McLaughlin is looking into the mysteries of conception.
Career Summary
Biography
Research Expertise
My research in the field of testicular biology has focused on spermatogonial development with particular emphasis on the identification and characterization of key regulators of spermatogonial stem cell replication (HOW), microRNA in germ cells, stem cell maintenance (Musashi), and male germ cell differentiation (c-Kit) and sperm function (Fertilin) (see McIver et al 2012 Human Reproduction Update, Monk et al 2010 Cell Stem Cell, Monk et al PLoS One 2012, Siddall et al 2006 PNAS, Prahbu et al 2006 Reproduction, McLaughlin et al 2001 Molecular Human Reproduction). In addition we study cytokines that control the activation of primordial follicles in the mammalian ovary and ovotoxic xenobiotics which cause oocyte loss and early menopause ( see Sutherland et al 2012 J Cellular Physiology, Sobinoff et al 2012, 2011, 2010 Toxicological Sciences, Blackmore et al 2004 Biology of Reproduction, Holt et al 2006 Developmental Biology, Hutt et al 2006 Biology of Reproduction, McLaughlin & McIver Reproduction 2009). In addition my lab has contributed to cell and molecular research in human and animal assisted reproduction with an emphasis on the characterization of gene and protein expression and function in male and female gametogenesis, reproductive tracts, roles in fertilization and as contraceptive targets (McLaughlin et al 2001, Asquith et al 2004, 2005, Nixon et al 2007, 2009, McLaughlin et al 2010, Redgrove et al 2011, Walker et al 2011).
Teaching Expertise
Senior Lecturer, Tutor & Demonstrator in Cell and Molecular Biology, Biochemistry, Immunobiology and Biotechnology (1000,2000 and 3000level) Implementation first ever Web-based delivery of all Level 1000 courses via Blackboard. Overseeing implementation of on-line assessments, and simulated laboratory computer experiments. Implementation Turnitin anti-plagiarism and collusion educational software for BIOL1000 cohort (2004). Awarded Graduate Certificate in Tertiary Teaching University of Newcastle 2006
Administrative Expertise
University Expertise Animal Ethics Committee Member Deputy Head of School of Environmental & Life Sciences Institutional Biosafety Committee Member ERA Cluster 8 committee member Animal Ethics Review Committee Member Faculty of Science Research and Research Training Committee Member Manager and Instructor-in-charge of Imaging Suite, Life Sciences Building (2001 - present) Chair of School Committee Review of Induction Materials for Honours students (2002 - 3) School Representative for Faculty of Science & IT International Committee (2004 - 2005) Biological Sciences Representative for School Research Higher Degree Progress Committee (2003 - present) Coordinator Level 1000 Biology - 500 students and 50 staff and Level 2000 Biology - 100 students and 10 staff Professional Activities Reviewer Grant Giving Bodies: NHMRC GRP member, Medical Research Council UK, the Biotechnology & Biological Sciences Research Council UK, and the Wellcome Trust. I also review for a number of specialist Reproduction journals. Positions in Learned Societies: President elect of Society for Reproductive Biology, Chairman of the British Andrology Society (1997-2000) and a Director of the Journal of Reproduction & Fertility (Ltd.). Committee member: British Fertility Society Association of Clinical Embryologists, Society for Reproductive Biology and the Society for Low Temperature Biology. Editor: multiple peer reviewed clinical guidelines and am an adviser to the United States of America Congress, Office of Technology Assessment and the UK Government Department of Health and the Human Fertilization and Embryology Authority.
Collaborations
Collaborators include: Dr Shaun Roman, Dr Brett Nixon, Prof John Aitken, Prof Adam McCluskey (University of Newcastle) Prof Keith Jones, Dr Janet Holt and Dr Julie Merriman Jones (University of Newcastle) Dr Gary Hime (University of Melbourne) and Prof Minx Fuller (Standford University) Prof Kate Loveland & Prof Moira O'Bryan (Monash University) Dr Darryl Russell and Dr Rebecca Robker (University of Adelaide) Prof Peter Koopman and Dr Jo Bowles (University of Queensland) Prof Ken Beagley (QUT) & Dr C Wira (Dartmouth University)
Qualifications
- PhD, University of Bristol
- Bachelor of Science (Honours), University of Glasgow - Scotland
Keywords
- Biochemistry
- Biology
- Biotechnology
- Immunobiology
- Ovarian Biology
- Reproductive Sciences
- Spermatogonial Stem Cells
Fields of Research
Code | Description | Percentage |
---|---|---|
060199 | Biochemistry and Cell Biology not elsewhere classified | 55 |
060699 | Physiology not elsewhere classified | 30 |
111499 | Paediatrics and Reproductive Medicine not elsewhere classified | 15 |
Professional Experience
Academic appointment
Dates | Title | Organisation / Department |
---|---|---|
1/11/2001 - 1/12/2004 | Lecturer | University of Newcastle School of Environmental and Life Sciences Australia |
1/1/2005 - 1/6/2008 | Senior Lecturer | University of Newcastle School of Environmental and Life Sciences Australia |
1/7/2008 - 1/4/2010 | Associate Professor | University of Newcastle School of Environmental and Life Sciences Australia |
1/4/2010 - | Professor | University of Newcastle School of Environmental and Life Sciences Australia |
Membership
Dates | Title | Organisation / Department |
---|---|---|
Programme Committee Member | Society for Reproductive Biology Australia |
Invitations
Participant
Year | Title / Rationale |
---|---|
2005 |
Primordial follicle activation and development Organisation: University of Adelaide |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (8 outputs)
Year | Citation | Altmetrics | Link | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2016 |
Holt JE, Stanger SJ, Nixon B, McLaughlin EA, 'Non-coding RNA in spermatogenesis and epididymal maturation', Advances in Experimental Medicine and Biology, Springer, Dordrecht 95-120 (2016) [B1]
|
||||||||||
2013 |
Sutherland JM, McLaughlin EA, Hime GR, Siddall NA, 'The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations', 233-245 (2013) [B1] In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have bee... [more] In order to maintain their unlimited capacity to divide, stem cells require controlled temporal and spatial protein expression. The Musashi family of RNA-binding proteins have been shown to exhibit this necessary translational control through both repression and activation in order to regulate multiple stem cell populations. This chapter looks in depth at the initial discovery and characterisation of Musashi in the model organism Drosophila, and its subsequent emergence as a master regulator in a number of stem cell populations. Furthermore the unique roles for mammalian Musashi-1 and Musashi-2 in different stem cell types are correlated with the perceived diagnostic power of Musashi expression in specific stem cell derived oncologies. In particular the potential role for Musashi in the identification and treatment of human cancer is considered, with a focus on the role of Musashi-2 in leukaemia. Finally, the manipulation of Musashi expression is proposed as a potential avenue towards the targeted treatment of specific aggressive stem cell cancers. © 2013 Springer Science+Business Media Dordrecht.
|
||||||||||
2012 | Sobinoff AP, Bernstein IR, McLaughlin EA, 'All your eggs in one basket: Mechanisms of xenobiotic induced female reproductive senescence', Senescence, InTech Press, Rijeka 559-584 (2012) [B1] | ||||||||||
2010 |
McLaughlin EA, Sobinoff AP, 'Contraception targets in mammalian ovarian development', Fertility Control, Springer, Berlin 45-66 (2010) [B1]
|
||||||||||
2009 | McLaughlin EA, Pacey AA, 'Cryopreservation and storage of spermatozoa', Textbook of Assisted Reproductive Technologies: Laboratory and Clinical Perspectives, Informa Healthcare, London 311-321 (2009) [B2] | ||||||||||
2004 | McLaughlin EA, 'Cryopreservation and storage of spermatozoa', Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives, Taylor & Francis, London 297-307 (2004) [B2] | ||||||||||
2002 | McLaughlin EA, Holland M, 'Developing Immunocontraceptives', Assisted Reproductive Technology: Accomplishments and New Horizons, Cambridge University Press, Cambridge, UK 355-365 (2002) [B1] | ||||||||||
Show 5 more chapters |
Journal article (166 outputs)
Year | Citation | Altmetrics | Link | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2020 |
Frost ER, Ford EA, Peters AE, Reed NL, McLaughlin EA, Baker MA, et al., 'Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line', Reproduction, Fertility and Development, 32 1027-1039 (2020) [C1]
|
||||||||||
2020 |
Ford E, Beckett EL, Roman S, McLaughlin EA, Sutherland J, 'Advances in human primordial follicle activation and premature ovarian insufficiency.', Reproduction, 159 R15-R29 (2020) [C1]
|
||||||||||
2020 |
Ford EA, Roman SD, McLaughlin EA, Beckett EL, Sutherland JM, 'The association between reproductive health smartphone applications and fertility knowledge of Australian women', BMC Women's Health, 20 (2020) [C1]
|
||||||||||
2020 |
Bryan ER, Redgrove KA, Mooney AR, Mihalas BP, Sutherland JM, Carey AJ, et al., 'Chronic testicular Chlamydia muridarum infection impairs mouse fertility and offspring development ', Biology of Reproduction, 102 888-901 (2020) [C1]
|
||||||||||
2020 |
Mihalas BP, Redgrove KA, Bernstein IR, Robertson MJ, McCluskey A, Nixon B, et al., 'Dynamin 2-dependent endocytosis is essential for mouse oocyte development and fertility', FASEB Journal, 34 5162-5177 (2020) [C1]
|
||||||||||
2019 |
Bryan ER, Kollipara A, Trim LK, Armitage CW, Carey AJ, Mihalas B, et al., 'Hematogenous dissemination of Chlamydia muridarum from the urethra in macrophages causes testicular infection and sperm DNA damage', Biology of Reproduction, 101 748-759 (2019) [C1]
|
||||||||||
2019 |
Bryan ER, McLachlan R, Rombauts L, Katz DJ, Yazdani A, Bogoevski K, et al., 'Detection of chlamydia infection within human testicular biopsies', HUMAN REPRODUCTION, 34 1891-1898 (2019) [C1]
|
||||||||||
2019 |
Zhou W, Stanger SJ, Anderson AL, Bernstein IR, De Iuliis GN, McCluskey A, et al., 'Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions.', BMC biology, 17 35-35 (2019) [C1]
|
||||||||||
2019 |
Bromfield E, Walters JLH, Cafe S, Bernstein I, Stanger SR, Anderson AL, et al., 'Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids', Molecular Human Reproduction, 25 241-256 (2019) [C1]
|
||||||||||
2019 |
Mihalas BP, Camlin NJ, Xavier MJ, Peters AE, Holt JE, Sutherland JM, et al., 'The small non-coding RNA profile of mouse oocytes is modified during aging', AGING-US, 11 2968-2997 (2019) [C1]
|
||||||||||
2018 |
Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Siddall NA, Koopman P, et al., 'RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis', JOURNAL OF CELLULAR PHYSIOLOGY, 233 3262-3273 (2018) [C1]
|
||||||||||
2018 |
Saeidi S, Shapouri F, de Iongh RU, Casagranda F, Sutherland JM, Western PS, et al., 'Esrp1 is a marker of mouse fetal germ cells and differentially expressed during spermatogenesis', PLOS ONE, 13 (2018) [C1]
|
||||||||||
2018 |
Micati DJ, Hime GR, McLaughlin EA, Abud HE, Loveland KL, 'Differential expression profiles of conserved Snail transcription factors in the mouse testis', ANDROLOGY, 6 362-373 (2018) [C1]
|
||||||||||
2018 |
Hall SE, Upton RMO, McLaughlin EA, Sutherland JM, 'Phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) and Janus kinase/signal transducer and activator of transcription (JAK/STAT) follicular signalling is conserved in the mare ovary', Reproduction, Fertility and Development, 30 624-633 (2018) [C1] © CSIRO 2018. The mare ovary is unique in its anatomical structure; however, the signalling pathways responsible for physiological processes, such as follicular activation, remain... [more] © CSIRO 2018. The mare ovary is unique in its anatomical structure; however, the signalling pathways responsible for physiological processes, such as follicular activation, remain uncharacterised. This provided us with the impetus to explore whether signalling molecules from important folliculogenesis pathways, phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) and Janus kinase/signal transducer and activator of transcription (JAK/STAT), are conserved in the mare ovary. Messenger RNA expression of six genes important in follicle development was measured using quantitative polymerase chain reaction and protein localisation of key pathway members (PI3K, AKT1, phosphatase and tensin homologue (PTEN), JAK1, STAT3 and suppressor of cytokine signalling 4 (SOCS4)) was compared in tissue from fetal and adult mare ovaries. Tissue from adult ovaries exhibited significantly increased levels of mRNA expression of PI3K, AKT1, PTEN, JAK1, STAT3 and SOCS4 compared with tissue from fetal ovaries. PI3K, AKT1, JAK1 and STAT3 demonstrated redistributed localisation, from pregranulosa cells in fetal development, to both the oocyte and granulosa cells of follicles in the adult ovary, whilst negative feedback molecules PTEN and SOCS4 were only localised to the granulosa cells in the adult ovary. These findings suggest that the PI3K/AKT and JAK/STAT signalling pathways are utilised during folliculogenesis in the mare, similarly to previously studied mammalian species, and may serve as useful biomarkers for assessment of ovary development in the horse.
|
||||||||||
2018 |
Sutherland JM, Frost ER, Ford EA, Peters AE, Reed NL, Seldon AN, et al., 'Janus Kinase JAK1 maintains the ovarian reserve of primordial follicles in the mouse ovary.', Molecular Human Reproduction, 24 533-542 (2018) [C1]
|
||||||||||
2018 |
Walters JLH, De Iuliis GN, Dun MD, Aitken RJ, McLaughlin EA, Nixon B, Bromfield EG, 'Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.', Biology of reproduction, 98 784-794 (2018) [C1]
|
||||||||||
2018 |
Mihalas BP, Bromfield EG, Sutherland JM, De Iuliis GN, McLaughlin EA, John Aitken R, Nixon B, 'Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity', Journal of Biological Chemistry, 293 18944-18964 (2018) [C1]
|
||||||||||
2017 |
Zhou W, De Iuliis GN, Turner AP, Reid AT, Anderson AL, McCluskey A, et al., 'Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis', BIOLOGY OF REPRODUCTION, 96 159-173 (2017) [C1]
|
||||||||||
2017 |
Bromfield EG, Aitken RJ, McLaughlin EA, Nixon B, 'Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse', MOLECULAR HUMAN REPRODUCTION, 23 91-105 (2017) [C1]
|
||||||||||
2017 |
Camlin NJ, Jarnicki AG, Vanders RL, Walters KA, Hansbro PM, McLaughlin EA, Holt JE, 'Grandmaternal smoke exposure reduces female fertility in a murine model, with great-grandmaternal smoke exposure unlikely to have an effect', HUMAN REPRODUCTION, 32 1270-1281 (2017) [C1]
|
||||||||||
2017 |
Sominsky L, Hodgson DM, McLaughlin EA, Smith R, Wall HM, Spencer SJ, 'Linking stress and infertility: a novel role for ghrelin', Endocrine Reviews, 38 432-467 (2017) [C1]
|
||||||||||
2017 |
Camlin NJ, McLaughlin EA, Holt JE, 'Motoring through: the role of kinesin superfamily proteins in female meiosis', HUMAN REPRODUCTION UPDATE, 23 409-420 (2017) [C1]
|
||||||||||
2017 |
Camlin NJ, McLaughlin EA, Holt JE, 'Kif4 Is Essential for Mouse Oocyte Meiosis', PLOS ONE, 12 (2017) [C1]
|
||||||||||
2017 |
Bromfield EG, Mihalas BP, Dun MD, Aitken RJ, McLaughlin EA, Walters JLH, Nixon B, 'Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced proteindamage in male germ cells', Biology of Reproduction, 96 598-609 (2017) [C1]
|
||||||||||
2017 |
Trinh TN, McLaughlin EA, Gordon CP, Bernstein IR, Pye VJ, Redgrove KA, McCluskey A, 'Small molecule Hedgehog pathway antagonists', ORGANIC & BIOMOLECULAR CHEMISTRY, 15 3046-3059 (2017) [C1]
|
||||||||||
2017 |
Mihalas BP, De Iuliis GN, Redgrove KA, McLaughlin EA, Nixon B, 'The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte', SCIENTIFIC REPORTS, 7 (2017) [C1]
|
||||||||||
2017 |
Mihalas BP, Redgrove KA, McLaughlin EA, Nixon B, 'Molecular mechanisms responsible for increased vulnerability of the ageing oocyte to oxidative damage', Oxidative Medicine and Cellular Longevity, 2017 1-22 (2017) [C1]
|
||||||||||
2017 |
Hutcheon K, McLaughlin EA, Stanger SJ, Bernstein IR, Dun MD, Eamens AL, Nixon B, 'Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa', RNA Biology, 14 1776-1790 (2017) [C1] © 2017 Taylor & Francis Group, LLC. Post-testicular sperm maturation and storage within the epididymis is a key determinant of gamete quality and fertilization competence. H... [more] © 2017 Taylor & Francis Group, LLC. Post-testicular sperm maturation and storage within the epididymis is a key determinant of gamete quality and fertilization competence. Here we demonstrate that mouse spermatozoa possess a complex small non-protein-coding RNA (sRNA) profile, the composition of which is markedly influenced by their epididymal transit. Thus, although microRNAs (miRNAs) are highly represented in the spermatozoa of the proximal epididymis, this sRNA class is largely diminished in mature spermatozoa of the distal epididymis. Coincident with this, a substantial enrichment in Piwi-interacting RNA (piRNA) abundance in cauda spermatozoa was detected. Further, features of cauda piRNAs, including; predominantly 29¿31 nts in length; preference for uracil at their 5' terminus; no adenine enrichment at piRNA nt 10, and; predominantly mapping to intergenic regions of the mouse genome, indicate that these piRNAs are generated by the PIWIL1-directed primary piRNA production pathway. Accordingly, PIWIL1 was detected via immunoblotting and mass spectrometry in epididymal spermatozoa. These data provide insight into the complexity and dynamic nature of the sRNA profile of spermatozoa and raise the intriguing prospect that piRNAs are generated in situ in maturing spermatozoa. Such information is of particular interest in view of the potential role for paternal sRNAs in influencing conception, embryo development and intergenerational inheritance.
|
||||||||||
2017 |
Zhou W, Anderson AL, Turner AP, De Iuliis GN, McCluskey A, McLaughlin EA, Nixon B, 'Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.', Molecular Human Reproduction, 23 657-673 (2017) [C1]
|
||||||||||
2017 |
Fuller EA, Sominsky L, Sutherland JM, Redgrove KA, Harms L, McLaughlin EA, Hodgson DM, 'Neonatal immune activation depletes the ovarian follicle reserve and alters ovarian acute inflammatory mediators in neonatal rats', BIOLOGY OF REPRODUCTION, 97 719-730 (2017) [C1]
|
||||||||||
2016 |
Redgrove KA, Bernstein IR, Pye VJ, Mihalas BP, Sutherland JM, Nixon B, et al., 'Dynamin 2 is essential for mammalian spermatogenesis', SCIENTIFIC REPORTS, 6 (2016) [C1]
|
||||||||||
2016 |
Bromfield EG, McLaughlin EA, Aitken RJ, Nixon B, 'Heat shock protein member A2 forms a stable complex with angiotensin convertingenzymeand protein disulfide isomerase A6 in human spermatozoa', Molecular Human Reproduction, 22 93-109 (2016) [C1]
|
||||||||||
2016 |
Shapouri F, Saeidi S, de Iongh RU, Casagranda F, Western PS, McLaughlin EA, et al., 'Tob1 is expressed in developing and adult gonads and is associated with the P-body marker, Dcp2', Cell and Tissue Research, 364 443-451 (2016) [C1] © 2015, Springer-Verlag Berlin Heidelberg. Tob1 is a member of the BTG/TOB family of proteins with established antiproliferative function. In Danio rerio and Xenopus laevis, the T... [more] © 2015, Springer-Verlag Berlin Heidelberg. Tob1 is a member of the BTG/TOB family of proteins with established antiproliferative function. In Danio rerio and Xenopus laevis, the Tob1 gene is expressed from the one-cell stage through to early gastrula stages, followed in later development by discrete expression in many tissues including the notochord and somites. In both mouse and human, Tob1 is expressed in many adult tissues including the testis and ovary; however, the specific cell types are unknown. We examine Tob1 gene expression in mouse in developing germ cells and in sorted male germ cells (gonocytes, spermatogonia, pachytene spermatocytes and round spermatids) by reverse transcription and droplet digital polymerase chain reaction (RT-ddPCR) and in adult ovary and testis by immunofluorescence with anti-Tob1 protein staining. By RT-ddPCR, Tob1 expression was low in developing male germ cells but was highly expressed in round spermatids. In developing female germ cells undergoing entry into meiosis, it increased 10-fold. Tob1 was also highly expressed in round spermatids and in oocytes in all stages of folliculogenesis. Notably, a marker for P-bodies, Dcp-2, was also highly expressed in round spermatids and all oocyte stages examined. The cytoplasmic presence of Tob1 protein in round spermatids and oocytes and the association of Tob1 protein with Dcp2 in both cell types suggest that Tob1 protein plays a role in post-transcriptional mechanisms.
|
||||||||||
2016 |
Stanger SJ, Law EA, Jamsai D, O'Bryan MK, Nixon B, McLaughlin EA, et al., 'A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation', FASEB Journal, 30 2777-2791 (2016) [C1] © 2016 FASEB. Spermatozoa require the process of capacitation to enable them to fertilize an egg. PKA is crucial to capacitation and the development of hyperactivated motility. Sp... [more] © 2016 FASEB. Spermatozoa require the process of capacitation to enable them to fertilize an egg. PKA is crucial to capacitation and the development of hyperactivated motility. Sperm PKA is activated by cAMP generated by the germ cell-enriched adenylyl cyclase encoded by Adcy10. Male mice lacking Adcy10 are sterile, because their spermatozoa are immotile. The current studywas designed to identify binding partners of the sperm-specific (Ca2) catalytic subunit of PKA (PRKACA) by using it as the "bait" in a yeast 2-hybrid system. This approach was used to identify a novel germ cell-enriched protein, sperm PKA interacting factor (SPIF), in 25% of the positive clones. Homozygous Spif-nullmice were embryonically lethal. SPIF was coexpressed and coregulated with PRKACA and with t-complex protein (TCP)-11, a protein associated with PKA signaling. We established that these 3 proteins form part of a novel complex in mouse spermatozoa. Upon capacitation, the SPIF protein becomes tyrosine phosphorylatedin > 95% of sperm. Anapparent molecular rearrangement in the complex occurs, bringing PRKACA and TCP11 into proximity. Taken together, these results suggest a role for the novel complex of SPIF, PRKACA, and TCP11 during spermcapacitation, fertilization, and embryogenesis.
|
||||||||||
2016 |
Reilly JN, McLaughlin EA, Stanger SJ, Anderson AL, Hutcheon K, Church K, et al., 'Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome', SCIENTIFIC REPORTS, 6 (2016) [C1]
|
||||||||||
2016 |
Camlin NJ, Sobinoff AP, Sutherland JM, Beckett EL, Jarnicki AG, Vanders RL, et al., 'Maternal Smoke Exposure Impairs the Long-Term Fertility of Female Offspring in a Murine Model.', Biol Reprod, 94 39 (2016) [C1]
|
||||||||||
2016 |
Trinh TN, McLaughlin EA, Abdel-Hamid MK, Gordon CP, Bernstein IR, Pye V, et al., 'Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors', ORGANIC & BIOMOLECULAR CHEMISTRY, 14 6304-6315 (2016) [C1]
|
||||||||||
2016 |
Kumar M, Camlin NJ, Holt JE, Teixeira JM, McLaughlin EA, Tanwar PS, 'Germ cell specific overactivation of WNT/beta catenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development', SCIENTIFIC REPORTS, 6 (2016) [C1]
|
||||||||||
2015 |
Sutherland JM, Sobinoff AP, Fraser BA, Redgrove KA, Davidson TL, Siddall NA, et al., 'RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus', FASEB Journal, 29 2759-2768 (2015) [C1] © FASEB. Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the process of gamete development, male germ cells experience... [more] © FASEB. Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the process of gamete development, male germ cells experience extended periods of inactive transcription despite requirements for continued growth and differentiation. Spermatogenesis therefore provides an ideal model to study the effects of posttranscriptional control on gene regulation. During spermatogenesis posttranscriptional regulation is orchestrated by abundantly expressed RNA-binding proteins. One such group of RNA-binding proteins is the Musashi family, previously identified as a critical regulator of testis germ cell development and meiosis in Drosophila and also shown to be vital to sperm development and reproductive potential in the mouse. We focus in depth on the role and function of the vertebrate Musashi ortholog Musashi-1 (MSI1). Through detailed expression studies and utilizing our novel transgenic Msi1 testis-specific overexpression model, we have identified 2 unique RNA-binding targets of MSI1 in spermatogonia,Msi2 and Erh, and have demonstrated a role for MSI1 in translational regulation. We have also provided evidence to suggest that nuclear import protein, IPO5, facilitates the nuclear translocation of MSI1 to the transcriptionally silenced XY chromatin domain in meiotic pachytene spermatocytes, resulting in the release of MSI1 RNA-binding targets. This firmly establishes MSI1 as a master regulator of posttranscriptional control during early spermatogenesis and highlights the significance of the subcellular localization of RNA binding proteins in relation to their function.
|
||||||||||
2015 |
Stenevi U, Lundström M, 'Can endophthalmitis be prevented?', Acta Ophthalmol, 93 301-302 (2015)
|
||||||||||
2015 |
Mihalas BP, Western PS, Loveland KL, McLaughlin EA, Holt JE, 'Changing expression and subcellular distribution of karyopherins during murine oogenesis', REPRODUCTION, 150 485-496 (2015) [C1]
|
||||||||||
2015 |
Anderson AL, Stanger SJ, Mihalas BP, Tyagi S, Holt JE, McLaughlin EA, Nixon B, 'Assessment of microRNA expression in mouse epididymal epithelial cells and spermatozoa by next generation sequencing', Genomics Data, 6 208-211 (2015) [C1] © 2015 Elsevier Inc. The mammalian epididymis is a highly specialized region of the male reproductive tract that is lined with a continuous layer of epithelial cells that display ... [more] © 2015 Elsevier Inc. The mammalian epididymis is a highly specialized region of the male reproductive tract that is lined with a continuous layer of epithelial cells that display a remarkable level of regionalized secretory and absorptive activity. The luminal environment created by this combined secretory and absorptive activity is directly responsible for promoting the functional maturation of spermatozoa and their maintenance in a quiescent and viable state prior to ejaculation. This study was designed to identify the complement of microRNAs (miRNAs) that are expressed within the mouse epididymal epithelial cells and the maturing populations of spermatozoa. Through the use of Next Generation Sequencing technology we have demonstrated that both epididymal epithelial cells and spermatozoa harbour a complex repertoire of miRNAs that have substantially different expression profiles along the length of the tract. These data, deposited in the Gene Expression Omnibus (GEO) with the accession numbers GSE70197 and GSE70198, afford valuable insight into the post-transcriptional control of gene expression within the epididymis and provide the first evidence for the dynamic transformation of the miRNA content of maturing sperm cells. Ultimately such information promises to inform our understanding of the aetiology of male infertility. Herein we provide a detailed description of the methodology used to generate these important data.
|
||||||||||
2015 |
Sobinoff AP, Dando SJ, Redgrove KA, Sutherland JM, Stanger SJ, Armitage CW, et al., 'Chlamydia muridarum infection-induced destruction of male germ cells and sertoli cells is partially prevented by Chlamydia major outer membrane protein-specific immune CD4 cells.', Biol Reprod, 92 27 (2015) [C1]
|
||||||||||
2015 |
Nixon B, Stanger SJ, Mihalas BP, Reilly JN, Anderson AL, Dun MD, et al., 'Next generation sequencing analysis reveals segmental patterns of microRNA expression in mouse epididymal epithelial cells', PLoS ONE, 10 (2015) [C1] © 2015 Nixon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and repro... [more] © 2015 Nixon et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The functional maturation of mammalian spermatozoa is accomplished as the cells descend through the highly specialized microenvironment of the epididymis. This dynamic environment is, in turn, created by the combined secretory and absorptive activity of the surrounding epithelium and displays an extraordinary level of regionalization. Although the regulatory network responsible for spatial coordination of epididymal function remains unclear, recent evidence has highlighted a novel role for the RNA interference pathway. Indeed, as noncanonical regulators of gene expression, small noncoding RNAs have emerged as key elements of the circuitry involved in regulating epididymal function and hence sperm maturation. Herein we have employed next generation sequencing technology to profile the genome-wide miRNA signatures of mouse epididymal cells and characterize segmental patterns of expression. An impressive profile of some 370 miRNAs were detected in the mouse epididymis, with a subset of these specifically identified within the epithelial cells that line the tubule (218). A majority of the latter miRNAs (75%) were detected at equivalent levels along the entire length of the mouse epididymis. We did however identify a small cohort of miRNAs that displayed highly regionalized patterns of expression, including miR-204-5p and miR-196b-5p, which were down- and up-regulated by approximately 39- and 45-fold between the caput/caudal regions, respectively. In addition we identified 79 miRNAs (representing ~ 21% of all miRNAs) as displaying conserved expression within all regions of the mouse, rat and human epididymal tissue. These included 8/14 members of let-7 family of miRNAs that have been widely implicated in the control of androgen signaling and the repression of cell proliferation and oncogenic pathways. Overall these data provide novel insights into the sophistication of the miRNA network that regulates the function of the male reproductive tract.
|
||||||||||
2015 |
Finke EH, Hickerson B, McLaughlin E, 'Parental Intention to Support Video Game Play by Children With Autism Spectrum Disorder: An Application of the Theory of Planned Behavior', LANGUAGE SPEECH AND HEARING SERVICES IN SCHOOLS, 46 154-165 (2015)
|
||||||||||
2015 |
Nixon B, Stanger SJ, Mihalas BP, Reilly JN, Anderson AL, Tyagi S, et al., 'The MicroRNA Signature of Mouse Spermatozoa Is Substantially Modified During Epididymal Maturation', Biology of Reproduction, 93 (2015) [C1] © 2015 by the Society for the Study of Reproduction, Inc. In recent years considerable effort has been devoted to understanding the epigenetic control of sperm development, leadin... [more] © 2015 by the Society for the Study of Reproduction, Inc. In recent years considerable effort has been devoted to understanding the epigenetic control of sperm development, leading to an increased appreciation of the importance of RNA interference pathways, and in particular miRNAs, as key regulators of spermatogenesis and epididymal maturation. It has also been shown that sperm are endowed with an impressive array of miRNA that have been implicated in various aspects of fertilization and embryo development. However, to date there have been no reports on whether the sperm miRNA signature is static or whether it is influenced by their prolonged maturation within the male reproductive tract. To investigate this phenomenon, we employed next-generation sequencing to systematically profile the miRNA signature of maturing mouse spermatozoa. In so doing we have provided the first evidence for the posttesticular modification of the sperm miRNA profile under normal physiological conditions. Such modifications include the apparent loss and acquisition of an impressive cohort of some 113 and 115 miRNAs, respectively, between the proximal and distal epididymal segments. Interestingly, the majority of these changes occur late in maturation and include the uptake of novel miRNA species in addition to a significant increase in many miRNAs natively expressed in immature sperm. Because sperm are not capable of de novo transcription, these findings identify the epididymis as an important site in establishing the sperm epigenome with the potential to influence the peri-conceptual environment of the female reproductive tract, contribute to the inheritance of acquired characteristics, and/or alter the developmental trajectory of the resulting offspring.
|
||||||||||
2015 |
Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation', FASEB JOURNAL, 29 2872-2882 (2015) [C1]
|
||||||||||
2015 |
Bromfield EG, Aitken RJ, Anderson AL, McLaughlin EA, Nixon B, 'The impact of oxidative stress on chaperone-mediated human sperm-egg interaction.', Hum Reprod, 30 2597-2613 (2015) [C1]
|
||||||||||
2015 |
Nixon B, Bromfield EG, Dun MD, Redgrove KA, McLaughlin EA, Aitken RJ, 'The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition', ASIAN JOURNAL OF ANDROLOGY, 17 568-573 (2015) [C1]
|
||||||||||
2015 |
Sutherland JM, Sobinoff AP, Gunter KM, Fraser BA, Pye V, Bernstein IR, et al., 'Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis.', Biomolecules, 5 1228-1244 (2015) [C1]
|
||||||||||
2014 |
Robker RL, Watson LN, Robertson SA, Dunning KR, McLaughlin EA, Russell DL, 'Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion', PLoS ONE, 9 (2014) [C1] The STAT3 transcription factor is a pleiotropic transducer of signalling by hormones, growth factors and cytokines that has been identified in the female reproductive tract from o... [more] The STAT3 transcription factor is a pleiotropic transducer of signalling by hormones, growth factors and cytokines that has been identified in the female reproductive tract from oocytes and granulosa cells of the ovary to uterine epithelial and stromal cells. In the present study we used transgenic models to investigate the importance of STAT3 for reproductive performance in these different tissues. The Cre-LoxP system was used to delete STAT3 in oocytes by crossing Stat3 fl/fl with Zp3-cre+ mice, or in ovarian granulosa cells and uterine stroma by crossing with Amhr2-Cre+ mice. Surprisingly, deletion of STAT3 in oocytes had no effect on fertility indicating that the abundance of STAT3 protein in maturing oocytes and fertilized zygotes is not essential to these developmental stages. In Stat3fl/fl;Amhr2-cre + females impaired fertility was observed through significantly fewer litters and smaller litter size. Ovulation rate, oocyte fertilization and development to blastocyst were unaffected in this line; however, poor recombination efficiency in granulosa cells had yielded no net change in STAT3 protein abundance. In contrast, uteri from these mice showed STAT3 protein depletion selectively from the stomal compartment. A significant reduction in number of viable fetuses on gestational day 18, increased fetal resorptions and disrupted placental morphology were evident causes of the reduced fertility. In conclusion, this study defines an important role for STAT3 in uterine stromal cells during embryo implantation and the development of a functional placenta. © 2014 Robker et al.
|
||||||||||
2014 |
Redgrove KA, McLaughlin EA, 'The role of the immune response in chlamydia trachomatis infection of the male genital tract: A double-edged sword', Frontiers in Immunology, 5 1-22 (2014) [C1]
|
||||||||||
2014 |
Camlin NJ, McLaughlin EA, Holt JE, 'Through the smoke: Use of in vivo and in vitro cigarette smoking models to elucidate its effect on female fertility', Toxicology and Applied Pharmacology, 281 266-275 (2014) [C1] © 2014 Elsevier Inc. A finite number of oocytes are established within the mammalian ovary prior to birth to form a precious ovarian reserve. Damage to this limited pool of gamete... [more] © 2014 Elsevier Inc. A finite number of oocytes are established within the mammalian ovary prior to birth to form a precious ovarian reserve. Damage to this limited pool of gametes by environmental factors such as cigarette smoke and its constituents therefore represents a significant risk to a woman's reproductive capacity. Although evidence from human studies to date implicates a detrimental effect of cigarette smoking on female fertility, these retrospective studies are limited and present conflicting results. In an effort to more clearly understand the effect of cigarette smoke, and its chemical constituents, on female fertility, a variety of in vivo and in vitro animal models have been developed. This article represents a systematic review of the literature regarding four of experimental model types: 1) direct exposure of ovarian cells and follicles to smoking constituents' in vitro, 2) direct exposure of whole ovarian tissue with smoking constituents in vitro, 3) whole body exposure of animals to smoking constituents and 4) whole body exposure of animals to cigarette smoke. We summarise key findings and highlight the strengths and weaknesses of each model system, and link these to the molecular mechanisms identified in smoke-induced fertility changes.
|
||||||||||
2014 |
Yun Y, Holt JE, Lane SIR, McLaughlin EA, Merriman JA, Jones KT, 'Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice', Cell Cycle, 13 1938-1947 (2014) [C1] Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, ... [more] Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, a protector of centromeric cohesion, is lost. Here we show that the most common mouse strain, C57Bl6/J, is resistant to maternal aging, showing little increase in aneuploidy or Sgo2 loss. Instead it demonstrates significant kinetochore-associated loss in the spindle assembly checkpoint protein Mad2 and phosphorylated Aurora C, which is involved in microtubule-kinetochore error correction. Their loss affects the fidelity of bivalent segregation but only when spindle organization is impaired during oocyte maturation. These findings have an impact clinically regarding the handling of human oocytes ex vivo during assisted reproductive techniques and suggest there is a genetic basis to aneuploidy susceptibility. © 2014 Landes Bioscience.
|
||||||||||
2014 |
Holt JE, Pye V, Boon E, Stewart JL, Garcia-Higuera I, Moreno S, et al., 'The APC/C activator FZR1 is essential for meiotic prophase I in mice', DEVELOPMENT, 141 1354-U327 (2014) [C1]
|
||||||||||
2014 |
Trinh TN, McLaughlin EA, Gordon CP, McCluskey A, 'Hedgehog signalling pathway inhibitors as cancer suppressing agents', MedChemComm, 5 117-133 (2014) [C1] The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation. By controlling the correct maturation o... [more] The Hedgehog (Hh) signalling pathway plays a pivotal role in the spatial and temporal regulation of cell proliferation and differentiation. By controlling the correct maturation of developing tissues and ensuring attainment of the correct size, position and the presence of fully functioning cellular structures, the Hh plays a pivotal role in development. Conversely aberrant Hh signalling is involved in Gorlin syndrome, basal cell carcinoma (the most common cancer in the world), and more than one third of all human medulloblastoma cases. In all of these cases, it is believed that deregulated Hh signalling leads to increased cell proliferation and tumour formation. Inhibition of the Hedgehog signalling pathway, is a recently validated anti-cancer drug target, with vismodegib (Erivedge¿), approved by the U.S. Food and Drug Administration for the treatment of adult basal cell carcinoma. In this perspective we outline the current state of Hh pathway inhibitors with a particular focus on potential limitations of upstream Hh pathway inhibition in relation to resistance mutations and crosstalk pathways. Together, these limitations indicate that inhibition of downstream components, specifically the Gli family of transcription factors, may represent a next generation approach to suppress tumours associated with aberrant Hh pathway signalling. © 2014 The Royal Society of Chemistry.
|
||||||||||
2014 |
Sahin Z, Szczepny A, Mclaughlin EA, Meistrich ML, Zhou W, Ustunel I, Loveland KL, 'Dynamic Hedgehog signalling pathway activity in germline stem cells', Andrology, 2 267-274 (2014) [C1] Summary: Although the contribution of Hedgehog (Hh) signalling to stem cell development and oncogenesis is well recognised, its importance for spermatogonial stem cells (SSCs) has... [more] Summary: Although the contribution of Hedgehog (Hh) signalling to stem cell development and oncogenesis is well recognised, its importance for spermatogonial stem cells (SSCs) has not been established. Here we interrogate adult rat SSCs using an established model in which only undifferentiated spermatogonial cells remain in the testis at 15 weeks following irradiation, and spermatogonial differentiation is induced within 4 weeks by gonadotrophin-releasing hormone antagonist (GnRH-ant) administration. Synthesis of Hh pathway components in untreated adult rat testes was compared with that in irradiated testes prior to and after GnRH-ant exposure using in situ hybridization. In adult testes with complete spermatogenesis, the Desert Hedgehog ligand transcript, Dhh, was detected in Sertoli cells, some spermatogonia and in spermatocytes by in situ hybridization. Spermatogenic cells were identified as sites of Hh signalling through detection of transcripts encoding the Hh receptor, Ptc2 transcripts and proteins for the key downstream target of Hh signalling, Gli1 and the Hh transcriptional activator, Gli2. Remarkably, the undifferentiated spermatogonia present in irradiated adult rat testes contained Dhh in addition to Ptc2, Gli1 and Gli2, revealing the potential for an autocrine Hh signalling loop to sustain undifferentiated spermatogonial cells. These transcripts became undetectable by in situ hybridization following GnRH-ant induction of spermatogonial differentiation, however, detection of Gli1 protein in spermatogonia in all groups indicates that Hh signalling is sustained. This is the first evidence of active Hh signalling in mammalian male germline stem cells, as has been documented for some cancer stem cells. © 2014 American Society of Andrology and European Academy of Andrology.
|
||||||||||
2014 |
Sutherland JM, Fraser BA, Sobinoff AP, Pye VJ, Davidson T-L, Siddall NA, et al., 'Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.', Biol Reprod, 90 92 (2014) [C1]
|
||||||||||
2014 |
Sobinoff AP, Sutherland JM, Beckett EL, Stanger SJ, Johnson R, Jarnicki AG, et al., 'Damaging legacy: maternal cigarette smoking has long-term consequences for male offspring fertility.', Hum Reprod, 29 2719-2735 (2014) [C1]
|
||||||||||
2013 |
McIver SC, Roman SD, Nixon B, Loveland KL, McLaughlin EA, 'The rise of testicular germ cell tumours: The search for causes, risk factors and novel therapeutic targets', F1000 Research, 2 1-11 (2013) [C1]
|
||||||||||
2013 |
Merriman JA, Lane SIR, Holt JE, Jennings PC, García-Higuera I, Moreno S, et al., 'Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice1', Biology of Reproduction, 88 (2013) [C1]
|
||||||||||
2013 |
Sobinoff AP, Beckett EL, Jarnicki AG, Sutherland JM, McCluskey A, Hansbro PM, McLaughlin EA, 'Scrambled and fried: Cigarette smoke exposure causes antral follicle destruction and oocyte dysfunction through oxidative stress', TOXICOLOGY AND APPLIED PHARMACOLOGY, 271 156-167 (2013) [C1]
|
||||||||||
2013 |
Davies RG, Wagstaff KM, McLaughlin EA, Loveland KL, Jans DA, 'The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins', Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833 3436-3444 (2013) [C1]
|
||||||||||
2013 |
Redgrove KA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human spermoocyte recognition', MOLECULAR HUMAN REPRODUCTION, 19 120-135 (2013) [C1]
|
||||||||||
2013 |
Sobinoff AP, Sutherland JM, Mclaughlin EA, 'Intracellular signalling during female gametogenesis', Molecular Human Reproduction, 19 265-278 (2013) [C1] Female reproductive potential is dictated by the size of the primordial follicle pool and the correct regulation of oocyte maturation and activation-events essential for productio... [more] Female reproductive potential is dictated by the size of the primordial follicle pool and the correct regulation of oocyte maturation and activation-events essential for production of viable offspring. Although a substantial body of work underpins our understanding of these processes, the molecular mechanisms of follicular and oocyte development are not fully understood. This review summarizes recent findings which have improved our conception of how folliculogenesis and oocyte competence are regulated, and discusses their implications for assisted reproductive techniques. We highlight evidence provided by genetically modified mouse models and in vitro studies which have refined our understanding of Pi3k/Akt and mTOR signalling in the oocyte and have discovered a role for Jak/Stat/Socs signalling in granulosa cells during primordial follicle activation. We also appraise a novel role for the metal ion zinc in the regulation of meiosis I and meiosis II progression through early meiosis inhibitor (Emi2) and Mos-Mapk signalling, and examine studies which expand our understanding of intracellular calcium signalling and extrinsic Plc¿ in stimulating oocyte activation. © The Author 2012. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
|
||||||||||
2013 |
O'Bryan MK, Clark BJ, McLaughlin EA, D'Sylva RJ, O'Donnell L, Wilce JA, et al., 'RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility', PLOS GENETICS, 9 (2013) [C1]
|
||||||||||
2013 |
Sominsky L, Sobinoff AP, Jobling MS, Pye V, McLaughlin EA, Hodgson DM, 'Immune regulation of ovarian development: programming by neonatal immune challenge.', Frontiers in Neuroscience, 7 100 (2013) [C1]
|
||||||||||
2013 |
McIver SC, Loveland KL, Roman SD, Nixon B, Kitazawa R, McLaughlin EA, 'The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis', ANDROLOGY, 1 517-529 (2013) [C1]
|
||||||||||
2012 |
Merriman-Jones JA, Jennings PC, McLaughlin EA, Jones KT, 'Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months', Biology of Reproduction, 86 1-6 (2012) [C1]
|
||||||||||
2012 |
Sominsky Bar L, Meehan CL, Walker AK, Bobrovskaya L, McLaughlin EA, Hodgson DM, 'Neonatal immune challenge alters reproductive development in the female rat', Hormones and Behavior, 62 345-355 (2012) [C1]
|
||||||||||
2012 |
Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL, McLaughlin EA, 'Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation', Journal of Cellular Physiology, 227 1188-1198 (2012) [C1]
|
||||||||||
2012 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Jumping the gun: Smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress', Toxicology and Applied Pharmacology, 260 70-80 (2012) [C1]
|
||||||||||
2012 |
Dun MD, Anderson AL, Bromfield EG, Asquith KL, Emmett BJ, McLaughlin EA, et al., 'Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)', International Journal of Andrology, 35 572-589 (2012) [C1]
|
||||||||||
2012 |
Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity', Toxicological Sciences, 128 258-271 (2012) [C1]
|
||||||||||
2012 |
McIver SC, Roman SD, Nixon B, McLaughlin EA, 'miRNA and mammalian male germ cells', Human Reproduction Update, 18 44-59 (2012) [C1]
|
||||||||||
2012 |
McIver SC, Stanger SJ, Santarelli DMF, Roman SD, Nixon B, McLaughlin EA, 'A unique combination of male germ cell mirnas coordinates gonocyte differentiation', PLoS One, 7 1-14 (2012) [C1]
|
||||||||||
2012 |
Siddall NA, Kalcina M, Johanson TM, Monk AC, Casagranda F, Been RP, et al., 'Drosophila Rbp6 Is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour', PloS One, 7 (2012) [C1]
|
||||||||||
2011 |
Gunter KM, McLaughlin EA, 'Translational control in germ cell development: A role for the RNA-binding proteins Musashi-1 and Musashi-2', IUBMB Life, 63 678-685 (2011) [C1]
|
||||||||||
2011 |
Monk AC, Siddall NA, Fraser BA, McLaughlin EA, Hime GR, 'Differential roles of HOW in male and female Drosophila germline differentiation', PLoS ONE, 6 (2011) [C1]
|
||||||||||
2011 |
Redgrove KA, Anderson AL, Dun MD, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae', Developmental Biology, 356 460-474 (2011) [C1]
|
||||||||||
2011 |
Nixon B, Mitchell LA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Proteomic and functional analysis of human sperm detergent resistant membranes', Journal of Cellular Physiology, 226 2651-2665 (2011) [C1]
|
||||||||||
2011 |
McLaughlin EA, Aitken RJ, 'Is there a role for immunocontraception?', Molecular and Cellular Endocrinology, 335 78-88 (2011) [C1]
|
||||||||||
2011 |
Walker AK, Hiles SA, Sominsky Bar L, McLaughlin EA, Hodgson DM, 'Neonatal lipopolysaccharide exposure impairs sexual development and reproductive success in the Wistar rat', Brain, Behavior, and Immunity, 25 674-684 (2011) [C1]
|
||||||||||
2011 |
Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA, 'Understanding the villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling', Toxicological Sciences, 123 563-575 (2011) [C1]
|
||||||||||
2010 |
Monk AC, Siddall NA, Volk T, Fraser BA, Quinn LM, McLaughlin EA, Hime GR, 'HOW is required for stem cell maintenance in the drosophila testis and for the onset of transit-amplifying divisions', Cell Stem Cell, 6 348-360 (2010) [C1]
|
||||||||||
2010 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Adding insult to injury: Effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility', Toxicological Sciences, 118 653-666 (2010) [C1]
|
||||||||||
2009 |
Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin MA, Aitken RJ, 'Composition and significance of detergent resistant membranes in mouse spermatozoa', Journal of Cellular Physiology, 218 122-134 (2009) [C1]
|
||||||||||
2009 |
Yu DMT, Ajami K, Gall MG, Park J, Lee CS, Evans KA, et al., 'The in vivo expression of dipeptidyl peptidases 8 and 9', Journal of Histochemistry & Cytochemistry, 57 1025-1038 (2009) [C1]
|
||||||||||
2009 |
McLaughlin EA, McIver SC, 'Awakening the oocyte: Controlling primordial follicle development', Reproduction, 137 1-11 (2009) [C1]
|
||||||||||
2008 |
Koppers AJ, De Iuliis GN, Read JM, McLaughlin EA, Aitken RJ, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
|
||||||||||
2007 |
Fitzsimmons C, McLaughlin EA, Mahony MJ, Clulow J, 'Optimisation of handling, activation and assessment procedures for Bufo marinus spermatozoa', Reproduction, Fertility and Development, 19 594-601 (2007) [C1]
|
||||||||||
2007 |
Aitken RJ, Wingate JK, De Iuliis GN, McLaughlin EA, 'Analysis of lipid peroxidation in human spermatozoa using BODIPY C11', Molecular Human Reproduction, 13 203-211 (2007) [C1]
|
||||||||||
2007 |
Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', Cellular and Molecular Life Sciences, 64 1805-1823 (2007) [C1]
|
||||||||||
2007 |
Aitken RJ, McLaughlin EA, 'Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state', Society of Reproduction and Fertility Supplement, 63 273-293 (2007) [C1]
|
||||||||||
2006 |
De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
|
||||||||||
2006 |
Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA, 'Cis-unsaturated Fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 4154-4163 (2006) [C1]
|
||||||||||
2006 |
Holt JE, Roman SD, Aitken RJ, McLaughlin EA, 'Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline', Genomics, 87 490-499 (2006) [C1]
|
||||||||||
2006 |
Curry BJ, Holt JE, McLaughlin EA, Aitken RJ, 'Characterization of structure and expression of the Dzip1 gene in the rat and mouse', Genomics, 87 275-285 (2006) [C1]
|
||||||||||
2006 |
Holt JE, Jackson A, Roman SD, Aitken RJ, Koopman PA, McLaughlin EA, 'CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary', Developmental Biology, 293 449-460 (2006) [C1]
|
||||||||||
2006 |
Hutt KJ, McLaughlin EA, Holland MK, 'Primordial follicle activation and follicular development in the juvenile rabbit ovary', Cell and Tissue Research, 326 809-822 (2006) [C1]
|
||||||||||
2006 |
Hutt KJ, McLaughlin EA, Holland MK, 'Kit ligand and c-Kit have diverse roles during mammalian oogenesis and folliculogenesis', Molecular Human Reproduction, 12 61-69 (2006) [C1]
|
||||||||||
2006 |
Prabhu SM, Meistrich ML, McLaughlin EA, Roman SD, Warne S, Mendis S, et al., 'Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis', Reproduction, 131 489-499 (2006) [C1]
|
||||||||||
2006 |
Siddall NA, McLaughlin EA, Marriner NL, Hime GR, 'The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity', Proceedings of the National Academy of Sciences of the United States of America, 103 8402-8407 (2006) [C1]
|
||||||||||
2006 |
Mackenzie SM, McLaughlin EA, Perkins HD, French N, Sutherland T, Jackson RJ, et al., 'Immunocontraceptive effects on female rabbits infected with recombinant myxoma virus expressing rabbit ZP2 or ZP3', Biology of Reproduction, 74 511-521 (2006) [C1]
|
||||||||||
2006 |
Hutt KJ, McLaughlin EA, Holland MK, 'KIT/KIT ligand in mammalian oogenesis and folliculogenesis: Roles in rabbit and murine ovarian follicle activation and oocyte growth', Biology of Reproduction, 75 421-433 (2006) [C1]
|
||||||||||
2005 |
Asquith KL, Bielanowicz AJ, McLaughlin EA, Nixon B, Aitken RJ, 'Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction', Biology of Reproduction, 72 328-337 (2005) [C1]
|
||||||||||
2005 |
Telfer EE, Gosden RG, Byskov AG, Spears N, Albertini D, Andersen CY, et al., 'On regenerating the ovary and generating controversy', Cell, 122 821-822 (2005) [C1]
|
||||||||||
2004 |
Blackmore DG, Baillie LR, Holt JE, Dierkx LM, Aitken RJ, McLaughlin EA, 'Biosynthesis of the Canine Zona Pellucida Requires the Integrated Participation of Both Oocytes and Granulosa Cells', Biology of Reproduction, 71 661-668 (2004) [C1]
|
||||||||||
2004 |
Baker MA, Krutskikh A, Curry BJ, McLaughlin EA, Aitken RJ, 'Identification of Cytochrome P450-Reductase as the Enzyme Responsible for NADPH-Dependent Lucigenin and Tetrazolium Salt Reduction in Rat Epididymal Sperm Preparations', Biology of Reproduction, 71 307-318 (2004) [C1]
|
||||||||||
2004 |
Asquith KL, Baleato R, McLaughlin EA, Nixon B, Aitken RJ, 'Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition', Journal of Cell Science, 117 3645-3657 (2004) [C1]
|
||||||||||
2004 |
Kerr PJ, Perkins HD, Inglis B, Stagg R, McLaughlin EA, Collins SV, Van Leeuwen BH, 'Expression of rabbit IL-4 by recombinant myxoma viruses enhances virulence and overcomes genetic resistance to myxomatosis', Virology, 324 117-128 (2004) [C1]
|
||||||||||
2004 |
Curry BJ, Su H, Law EG, McLaughlin EA, Nixon B, Aitken RJ, 'Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells', Genomics, 84 406-418 (2004) [C1]
|
||||||||||
2004 |
Aitken RJ, Ryan AL, Baker MA, McLaughlin EA, 'Redox activity associated with the maturation and capacitation of mammalian spermatozoa', Free Radical Biology and Medicine, 36 994-1010 (2004) [C1]
|
||||||||||
2003 |
McLaughlin EA, Holland MK, Aitken RJ, 'Contraceptive vaccines', Expert Opinion on Biological Therapy, 3 829-841 (2003) [C1]
|
||||||||||
2002 |
Hancock P, McLaughlin EA, 'British Andrology Society guidelines for the assessment of post vasectomy semen samples', Journal of Clinical Pathology, 55 812-816 (2002) [C1]
|
||||||||||
2002 |
McLaughlin EA, 'Cryopreservation, screening and storage of sperm The challenges for the twenty-first century', Human Fertility, 5 S61-S65 (2002) [C1] The advent of HIV and the serious nature of the sequelae resulted in a major reassessment of artificial insemination practices in the UK. The development of human semen cryopreser... [more] The advent of HIV and the serious nature of the sequelae resulted in a major reassessment of artificial insemination practices in the UK. The development of human semen cryopreservation had enormous impact on reproductive medicine and the availability of cryopreserved quarantined donor semen became a mainstay for the treatment of male infertility in the UK. The regulation and accreditation of assisted reproductive technologies and the introduction of peer-reviewed guidelines have largely standardized clinical and laboratory practice. The introduction of assisted fertilization techniques such as intracytoplasmic sperm injection, testicular sperm retrieval and improved oncology treatments have placed pressure on reproductive biologists and cryobiologists to design and use cryopreservation protocols for the optimum survival of sperm. © 2002, Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. All rights reserved.
|
||||||||||
2001 |
Ford WCL, Williams KM, Harrison S, Rees JM, Ray BD, McLaughlin EA, Hull MGR, 'Value of the hamster oocyte test and computerised measurements of sperm motility in predicting if four or more viable embryos will be obtained in an IVF cycle', INTERNATIONAL JOURNAL OF ANDROLOGY, 24 109-119 (2001) [C1]
|
||||||||||
2001 |
McLaughlin EA, Frayne J, Bloomberg G, Hall L, 'Do fertilin beta and cyritestin play a major role in mammalian sperm-oolemma interactions? A critical re-evaluation of the use of peptide mimics in identifying specific oocyte recognition proteins', MOLECULAR HUMAN REPRODUCTION, 7 313-317 (2001)
|
||||||||||
2000 | McLaughlin EA, 'Recruitment of only cytomegalovirus (CMV) negative semen donors', HUMAN REPRODUCTION, 15 2248-2249 (2000) | ||||||||||
2000 |
McLaughlin EA, 'Recruitment of only cytomegalovirus (CMV) negative semen donors', HUMAN REPRODUCTION, 15 2247-2247 (2000)
|
||||||||||
2000 |
Curson R, Karakosta C, McLaughlin EA, 'Recruitment of only cytomegalovirus (CMV) negative semen donors (multiple letters)', Human Reproduction, 15 2247-2249 (2000)
|
||||||||||
2000 |
Curson R, Karakosta C, 'Recruitment of only cytomegalovirus (CMV) negative semen donors', HUMAN REPRODUCTION, 15 2247-2248 (2000)
|
||||||||||
2000 |
Turner K, Troup S, Morroll D, Glew A, McLaughlin E, Avery S, et al., 'Accreditation standards and guidelines for IVF laboratories', Human Fertility, 3 174-180 (2000)
|
||||||||||
1999 |
Whittington K, Harrison SC, Williams KM, Day JL, Mclaughlin EA, Hull MGR, Ford WCL, 'Reactive oxygen species (ROS) production and the outcome of diagnostic tests of sperm function', INTERNATIONAL JOURNAL OF ANDROLOGY, 22 236-242 (1999)
|
||||||||||
1999 |
McLaughlin EA, 'Ensuring the safe cryopreservation of tissues & cells', CRYO-LETTERS, 20 133-136 (1999)
|
||||||||||
1998 |
McLaughlin EA, Day J, Harrison S, Mitchell J, Prosser C, Hull M, 'Recruitment of gamete donors and payment of expenses', HUMAN REPRODUCTION, 13 1130-1132 (1998)
|
||||||||||
1998 |
Hull MGR, Williams JAC, Ray B, McLaughlin EA, Akande VA, Ford WCL, 'The contribution of subtle oocyte or sperm dysfunction affecting fertilization in endometriosis-associated or unexplained infertility: A controlled comparison with tubal infertility and use of donor spermatozoa', HUMAN REPRODUCTION, 13 1825-1830 (1998)
|
||||||||||
1998 |
Williams K, Frayne J, McLaughlin EA, Hall L, 'Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein', MOLECULAR HUMAN REPRODUCTION, 4 235-242 (1998)
|
||||||||||
Show 163 more journal articles |
Review (6 outputs)
Year | Citation | Altmetrics | Link | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2015 |
Sutherland JM, Siddall NA, Hime GR, McLaughlin EA, 'RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family', ASIAN JOURNAL OF ANDROLOGY (2015) [C1]
|
||||||||||
2013 |
McIver SM, Roman SD, Nixon B, Loveland KL, McLaughlin EA, 'The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets', F1000Research (2013)
|
||||||||||
2013 |
Loveland KL, McLaughlin EA, 'Hidden gems in the niche: a new approach to the study of spermatogonial stem cells', ASIAN JOURNAL OF ANDROLOGY (2013) [C3]
|
||||||||||
2011 |
McLaughlin EA, Hime GR, 'Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis?', Asian Journal of Andrology (2011) [C2]
|
||||||||||
2007 |
Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', CELLULAR AND MOLECULAR LIFE SCIENCES (2007) [D1]
|
||||||||||
1998 |
Avery SM, McLaughlin EA, Dawson KJ, 'Safe cryopreservation of sperm and embryos', Human Fertility (1998)
|
||||||||||
Show 3 more reviews |
Conference (72 outputs)
Year | Citation | Altmetrics | Link | |||||
---|---|---|---|---|---|---|---|---|
2018 |
De Iuliis GN, Milhalas BP, Redgrove KA, McLaughlin EA, Nixon B, 'Mechanisms responsible for the age-related decline in oocyte quality: the use of antioxidants to halt the aging process in eggs', Hunter Valley, NSW (2018)
|
|||||||
2017 |
Siddall N, Sutherland J, McLaughlin E, Hime G, 'Drosophila Musashi is required in the ovary to regulate follicle stem cell behaviour and maintain niche homeostasis', MECHANISMS OF DEVELOPMENT, Natil Univ Singapore, Singapore, SINGAPORE (2017)
|
|||||||
2016 |
Saeidi SS, Shapouri F, De Iongh R, Casagranda F, Western P, McLaughlin E, et al., 'The role of ESRP1 during gametogenesis', CLINICAL ENDOCRINOLOGY, Adelaide, AUSTRALIA (2016)
|
|||||||
2014 | Adler J, Pratt J, Werger N, Marquez A, McLaughlin E, Markmann J, Yeh H, 'Psychosocial and Economic Differences Between Donors and Recipients', TRANSPLANTATION, San Francisco, CA (2014) | |||||||
2012 |
Sobinoff AP, Beckett EL, Nixon B, Roman SD, Hansbro PM, McLaughlin EA, 'The impact of maternal cigarette smoke exposure on the male germline', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
|
|||||||
2012 |
Sutherland JM, Fraser BA, Siddall NA, Hime GR, Davidson T-L, Koopman P, McLaughlin EA, 'Musashi-2: an essential regulator of DNA recombination and repair', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
|
|||||||
2012 |
Sominsky Bar L, Moussavi M, Sobinoff AP, McLaughlin EA, Hodgson DM, 'Postnatal peripheral inflammatory challenge alters expression of ovarian signalling pathway - Implications for impaired reproductive development', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
|
|||||||
2012 | Loveland K, McLaughlin EA, Szczepny A, Jans D, 'Expression of hedgehog pathway regulators in the adult testis reveals dynamic control of signalling activity', Journal of Andrology, Tucson, AZ (2012) [E3] | |||||||
2012 |
Sominsky Bar L, Meehan CL, Walker AK, Bobrovskaya L, McLaughlin EA, Hodgson DM, 'Programming of reproductive development by neonatal immunological challenge: Evidence for transgenerational inheritance', Brain, Behavior, and Immunity, San Diego, CA (2012) [E3]
|
|||||||
2010 | Siddall NA, Monk AC, Horvay K, Kalcina M, Johanson TM, Casagranda F, et al., 'Genetic regulation of stem cell differentiation by transcriptional and translational repressors', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts, Melbourne, Vic (2010) [E3] | |||||||
2010 | McLaughlin EA, Fraser BA, Pye VJ, Bigland MJ, Siddall NA, Hime GR, 'RNA binding protein Msi2: Cell cycle regulator in spermatogenesis', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Abstracts, Melbourne, Vic (2010) [E3] | |||||||
2010 |
Fraser BA, Sobinoff AP, Pye VJ, Roman SD, Hime GR, Siddall NA, et al., 'Targets of RNA-binding protein Musashi-1 in mouse germ cell development', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]
|
|||||||
2010 |
McIver SC, Roman SD, Nixon B, McLaughlin EA, 'MicroRNA signalling in early male germ cells', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
|
|||||||
2010 |
Pye VJ, Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Xenobiotics; influence on long term oocyte viability', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
|
|||||||
2010 |
Redgrove KA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Identification and characterisation of surface protein complexes in human spermatozoa', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
|
|||||||
2010 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Consistent mechanism of primordial follicle activation in neonatal mouse ovotoxicity', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
|
|||||||
2010 |
Redgrove KA, Nixon B, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Identification and Characterisation of Surface Protein Complexes in Human Spermatozoa', Reproduction, Fertility and Development, Sydney (2010) [E3]
|
|||||||
2010 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Short Term Xenobiotic Exposure Compromises Long Term Oocyte Viability', Reproduction, Fertility and Development, Sydney (2010) [E3]
|
|||||||
2010 |
Sutherland JM, Keightley RA, Robker RL, Russell DL, McLaughlin EA, 'JAK/STAT Signalling in Folliculogenesis', Reproduction, Fertility and Development, Sydney (2010) [E3]
|
|||||||
2010 | Watson LN, Robker RL, Dunning KR, McLaughlin EA, Russell DL, 'Conditional Targeted Deletions of STAT3 to Identify its Role in Oocytes and Granulosa Cells', Reproduction, Fertility and Development, Sydney (2010) [E3] | |||||||
2010 |
McIver SC, Roman SD, Nixon B, McLaughlin EA, 'Microrna and Early Male Germ Cells', Reproduction, Fertility and Development, Sydney (2010) [E3]
|
|||||||
2010 | Gunter KM, Fraser BA, Sobinoff AP, Pye VJ, Siddall NA, Hime GR, McLaughlin EA, 'Translational Control in Folliculogenesis and Oocyte Development: A Role for RNA-Binding Protein Musashi-1', Reproduction, Fertility and Development, Sydney (2010) [E3] | |||||||
2010 | McLaughlin EA, Fraser BA, Pye VJ, Bigland MJ, Siddall NA, Hime GR, 'Musashi Family of RNA Binding Proteins: Cell Cycle Regulators in Spermatogenesis', Reproduction, Fertility and Development, Sydney (2010) [E3] | |||||||
2010 |
Hopkins LA, Pye VJ, Fraser BA, Holt JE, Jones KT, McLaughlin EA, 'The Role of Fizzy Related 1 in Male Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
|
|||||||
2010 |
Anderson AL, Mitchell LA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Proteomic and Functional Analysis of Human Sperm Detergent Resistant Membranes', Reproduction, Fertility and Development, Sydney (2010) [E3]
|
|||||||
2010 | Bernstein IR, McLaughlin EA, O'Bryan MK, 'SLX4, A Key Regulator of Meisosis and DNA Repair in the Male Germline', Reproduction, Fertility and Development, CSIRO Publishing (2010) [E3] | |||||||
2010 |
Tannock SJ, McLaughlin EA, Aitken RJ, Roman SD, 'SPIF - A Novel Testis-Specific Gene and its Interaction with PKA', Reproduction, Fertility and Development, Sydney (2010) [E3]
|
|||||||
2009 |
Roman SD, Stanger SJ, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Characterisation of spermatogonial stem cells', Regulatory Networks in Stem Cells: Program & Abstract Book, Singapore (2009) [E3]
|
|||||||
2008 |
Fraser BA, Sobinoff A, Hime G, Siddall N, Roman SD, McLaughlin EA, 'The role of the RNA-binding protein, Musashi-1 in murine spermatogonial stem cell maintenance', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
|
|||||||
2008 |
Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin M, Aitken RJ, 'The composition and significance of lipid rafts in mouse spermatozoa', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
|
|||||||
2008 |
McLaughlin EA, Gunter KM, Woollett K, Roman SD, 'Chemokines: Role in germ cell migration and survival', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
|
|||||||
2007 |
Gunter KM, Fraser BA, Holt JE, Stanger SJ, Aitken RJ, Roman SD, McLaughlin EA, 'CXCR4/SDF1 interaction in the neonatal mouse testes', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
|
|||||||
2007 |
Koppers AJ, McLaughlin EA, Aitken RJ, 'Mitochondria are a significant source of reactive oxygen species in human spermatozoa', Combined Conference Abstracts - ComBio 2007 Conference, Sydney (2007) [E3]
|
|||||||
2007 | Hime GR, Siddall NA, Monk AC, Marriner NL, McLaughlin EA, 'Genetics of stem cells - How fruitflies can assist reproductive technology', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3] | |||||||
2007 | McLaughlin EA, 'Under attack: Germ cell defences against environmental toxins?', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3] | |||||||
2007 |
Roman SD, Stanger SJ, Fraser BA, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Isolating and genotyping spermatogonial stem cells', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
|
|||||||
2006 |
Fraser BA, Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, et al., 'CXCR4/SDF1 Interactionin the Embryonic and Neonatal Mpise Testes', Abstracts, Brisbane Convention Centre, QLD, Australia (2006) [E3]
|
|||||||
2006 |
McLaughlin EA, Dorey RA, Roman SD, Aitken RJ, 'Xenobiotis and Fertility: Expression Profiling of Defence Mechanisms Present in Murine Ovary', Abstract Book, Lorne, VIC, Australia (2006) [E3]
|
|||||||
2006 |
Schjenken JE, Gilliam E, Borg Z, Aitken RJ, McLaughlin EA, Roman SD, 'Cytocrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line', Abstract Book, Lorne, VIC, Australia (2006) [E3]
|
|||||||
2006 |
Aitken RJ, 'Impact of unsaturated fatty acids on human sperm function', Abstracts, Qwest Center Omaha, Omaha, Nebraska (2006) [E3]
|
|||||||
2006 |
Aitken RJ, McLaughlin EA, 'Molecular mechanism in spem capacitation: progesterone induced secondary calcium oscillations reflect the attainment of a capacitated state', Book of Abstracts, New Delhi (2006) [E3]
|
|||||||
2006 |
Paul JW, Aitken RJ, McLaughlin EA, 'Oolemmal Proteomics: Characterisation of Glycophosphatidylinositol Anchored Proteins Involved in Murine Fertilisation', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
|
|||||||
2006 |
Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, Peter K, McLaughlin EA, 'CXCR4/SDF-1 interaction in the embryonic and neonatal mouse tests', Book of Abstracts, Chicago, Illinois (2006) [E3]
|
|||||||
2005 | Ellem GK, McLaughlin EA, 'Tales from the coalface: From tragedy to triumph in a blended learning approach to the teaching of 1st year biology', Proceedings of the Blended Learning in Science Teaching and Learning Symposium, Sydney, NSW (2005) [E1] | |||||||
2005 |
Holt JE, Aitken RJ, Roman SD, McLaughlin E, 'Use of RNA interference for the functional analysis of genes involved in ovarian development', MECHANISMS OF DEVELOPMENT (2005) [E3]
|
|||||||
2005 |
Hime G, Marriner N, McLaughlin E, Roman S, Loveland K, Siddall N, 'The RNA-binding protein musashi is required for stem cell maintenance in the Drosophila testis', MECHANISMS OF DEVELOPMENT (2005) [E3]
|
|||||||
2004 |
Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Expression of the Chemokine CXCL12 and its receptor CXCR4 in the activating Mammalian Ovarian follicle', Reproduction, Fertility and Development, Sydney (2004) [E3]
|
|||||||
2004 |
Paul JW, McLaughlin EA, Aitken RJ, 'Oolemmal Proteomics: Identification of the Oocyte Cell Surface Protein Complexes Involved in Sperm-egg Interaction', Reproduction, Fertility and Development, Sydney (2004) [E3]
|
|||||||
2004 | Hutt KJ, McLaughlin EA, Holland MK, 'Kit Ligand promotes follicle activation in cultured neonatal mouse ovaries but not in cultured rabbit ovarian cortical explants', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3] | |||||||
2004 |
Asquith KL, Nixon B, McLaughlin EA, Aitken RJ, 'Tyrosine phosphorylation of mouse sperm proteins in a prerequisite for Zona Pellucida binding: potential involvement of molecular chaperones', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3]
|
|||||||
2004 |
Roman SD, McLaughlin EA, 'Peer pressure and performance: meaningful team work', Proceedings of Scholarly Inquiry into Science Teaching and Leaning, University of Sydney (2004) [E3]
|
|||||||
2003 |
Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Gene expression in the activating mammalian ovarian follicle', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
|
|||||||
2003 |
Blackmore DG, McLaughlin EA, Aitken RJ, 'Lectin expression patterns of feline and canine oogenesis', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
|
|||||||
2003 |
Asquith KL, McLaughlin EA, Nixon B, Aitken RJ, 'Localisation of Tyrosine Phosphorylated Proteins on Mouse Spermatozoa during Zona Pellucida Interaction and Characterisation of Sperm Surface Phosphoproteins', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3]
|
|||||||
2003 | Hutt KJ, McLaughlin EA, Holland MK, 'The effect of kit ligand on follicle growth initiation in cultured rabbit and mouse ovaries', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3] | |||||||
2002 | McLaughlin EA, Robinson A, Inglis B, Swan J, Holland M, Kerr P, 'Immunocontraceptive effect of recombinant porcine Zona Pellucida C protein in rabbits', Proceedings of the Thirty-third Annual Conference of the Society for Reproductive Biology, Adelaide, SA (2002) [E3] | |||||||
Show 69 more conferences |
Grants and Funding
Summary
Number of grants | 88 |
---|---|
Total funding | $35,100,961 |
Click on a grant title below to expand the full details for that specific grant.
20181 grants / $178,000
Male Chlamydia infections: The key role of macrophages in testicular dissemination and disrupted spermatogenesis$178,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Kenneth Beagley, Professor Eileen McLaughlin, Dr Alison Carey, Associate Professor Tim Dargaville |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2019 |
GNo | G1800415 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
20171 grants / $7,000
Jennie Thomas Travel Award$7,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Miss Bettina Mihalas, Professor Brett Nixon, Professor Eileen McLaughlin |
Scheme | Jennie Thomas Medical Research Travel Grant |
Role | Investigator |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | G1701509 |
Type Of Funding | C3120 - Aust Philanthropy |
Category | 3120 |
UON | Y |
20165 grants / $1,488,556
The role of dynamin in spermatogenesis, sperm maturation and sperm-oocyte interactions$567,478
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Brett Nixon, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2018 |
GNo | G1500178 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Investigation of the mechanisms underpinning HSPA2 dysfunction in the spermatozoa of infertile patients$494,958
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Brett Nixon, Laureate Professor John Aitken, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2018 |
GNo | G1500165 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Persistent Chlamydial infection in the Male germline$365,186
Funding body: University of Auckland
Funding body | University of Auckland |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2018 |
GNo | G1601219 |
Type Of Funding | C3212 - International Not for profit |
Category | 3212 |
UON | Y |
Beckman Coulter Optima Max-TL, Benchtop Ultra Centrifuge, TLA-110 Fixed-Angle Rotor Package, TLS-55 Swinging Bucket Rotor Package$40,934
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Brett Nixon, Laureate Professor John Aitken, Professor Eileen McLaughlin, Associate Professor Mark Baker, Doctor Jessie Sutherland, Doctor Elizabeth Bromfield |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2016 |
GNo | G1601314 |
Type Of Funding | C2120 - Aust Commonwealth - Other |
Category | 2120 |
UON | Y |
Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship$20,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Miss Bettina Mihalas, Professor Brett Nixon, Professor Eileen McLaughlin |
Scheme | Postgraduate Research Scholarship |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | G1601053 |
Type Of Funding | C3120 - Aust Philanthropy |
Category | 3120 |
UON | Y |
20147 grants / $1,191,850
Chlamydia infection in males $652,019
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Kenneth Beagley |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2016 |
GNo | G1300117 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
miRNA regulation of sperm maturation $396,157
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Brett Nixon, Professor Eileen McLaughlin, Doctor Janet Bristow |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2016 |
GNo | G1300125 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
JuLI Stage $71,674
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Pradeep Tanwar, Professor Eileen McLaughlin, Conjoint Professor Robin Callister, Professor Xu Dong Zhang, Professor Murray Cairns, Professor Brett Nixon, Professor Hubert Hondermarck, Associate Professor Phillip Dickson, Associate Professor Nikki Verrills, Associate Professor Matt Dun, Doctor Jessie Sutherland, Doctor Janani Kumar, Associate Professor Jay Horvat, Associate Professor Susan Hua, Professor Liz Milward, Associate Professor Estelle Sontag, Professor Dirk Van Helden, Doctor Janet Bristow, Doctor Jean-Marie Sontag |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1500860 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
The Role of the GTPase Dynamin in the Female Germline$30,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Kate Redgrove, Doctor Janet Bristow, Professor Eileen McLaughlin, Professor Brett Nixon |
Scheme | Bridging Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1301333 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
The role of dynamin is spermatogenesis and sperm-oocyte interactions$20,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Brett Nixon, Professor Eileen McLaughlin, Professor Adam McCluskey |
Scheme | Near Miss Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1301400 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Understanding the Effects of Persistent Chlamydia Infection in the Male Germline$20,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Kate Redgrove, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1401440 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
Faculty PVC Conference Assistance Grant 2014$2,000
Funding body: University of Newcastle - Faculty of Science & IT
Funding body | University of Newcastle - Faculty of Science & IT |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | PVC Conference Assistance Grant |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1401229 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20135 grants / $362,182
Novel function of heat shock protein 2A in the regulation of human sperm-egg interactions$292,182
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Brett Nixon, Laureate Professor John Aitken, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2015 |
GNo | G1200193 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Pradeep Tanwar, Professor Eileen McLaughlin, Professor Xu Dong Zhang, Conjoint Professor Robert Callister, Associate Professor Phillip Dickson, Professor Hubert Hondermarck, Doctor Jean-Marie Sontag, Professor Dirk Van Helden, Associate Professor Doug Smith, Associate Professor Phil Jobling, Associate Professor Estelle Sontag, Associate Professor Paul Tooney, Associate Professor Susan Hua, Doctor Janet Bristow, Associate Professor Jay Horvat, Professor Liz Milward, Professor Adam McCluskey, Professor Brett Nixon, Associate Professor Rebecca Lim, Professor Alan Brichta |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1201185 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Chlamydia - Vaccine development to prevent adverse reproductive outcomes in males.$15,000
Funding body: University of Newcastle - Faculty of Science & IT
Funding body | University of Newcastle - Faculty of Science & IT |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Strategic Small Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1401066 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Dynamin - role in sperm oocyte interaction$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Brett Nixon, Professor Adam McCluskey |
Scheme | Near Miss Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1300483 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Dynamin - role in sperm oocyte interaction$10,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Brett Nixon, Professor Adam McCluskey |
Scheme | Near Miss |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1300700 |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | Y |
20126 grants / $480,100
Role of Musashi in the regulation of cell cycle proteins$280,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Dr Gary Hime, Professor Margaret Fuller |
Scheme | Discovery Projects |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2014 |
GNo | G1100068 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Hedgehog Signalling in Spermatogenesis$150,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Dr Kate Loveland, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2014 |
GNo | G1101100 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
The effects of cigarette smoke on the reproductive health of offspring using our unique mouse model.$15,100
Funding body: University of Newcastle - Faculty of Science & IT
Funding body | University of Newcastle - Faculty of Science & IT |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Strategic Small Grant |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1401103 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
BMG SPECTROstar Nano$15,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Associate Professor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1100971 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Associate Professor Ian Grainge |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1100986 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
The role of miRNAs in the regulation of sperm maturation$10,000
Funding body: University of Newcastle - Faculty of Science & IT
Funding body | University of Newcastle - Faculty of Science & IT |
---|---|
Project Team | Professor Brett Nixon, Professor Eileen McLaughlin, Doctor Natalie Beveridge |
Scheme | Strategic Initiative Research Fund (SIRF) |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1401028 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20118 grants / $2,219,139
Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm$644,178
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Professor Sergio Moreno |
Scheme | Discovery Projects |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2014 |
GNo | G1000020 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Establishment of a comprehensive regional biophysical analysis facility $500,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1000630 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Chemical Biology$444,961
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Adam McCluskey, Doctor Warwick Belcher, Associate Professor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Emeritus Professor Ray Rose, Doctor Jennette Sakoff, Associate Professor Nikki Verrills |
Scheme | Priority Research Centre |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2013 |
GNo | G1100052 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Establishment of a Biomolecular Analysis Facility$325,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Peter Lewis, Professor Eileen McLaughlin, Professor Adam McCluskey, Laureate Professor Paul Foster, Laureate Professor John Aitken |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1000465 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Establishment of a comprehensive regional biophysical analysis facility $230,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) Partner Funding |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1100484 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Towards a Chlamydia vaccine for males: The key role of mucosal IgA$35,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Kenneth Beagley, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G0190618 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
SLX4 - a key regulator of male germ cell development and DNA repair$25,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Brett Nixon |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1001000 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Associate Professor Ian Grainge, Doctor Janet Bristow, Doctor Xiao Yang |
Scheme | Equipment Grant |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1100028 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20109 grants / $3,160,904
Development of a humane non-surgical sterilization method for domestic animals$1,006,825
Funding body: Found Animals Foundation Inc
Funding body | Found Animals Foundation Inc |
---|---|
Project Team | Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Adam McCluskey |
Scheme | Michelson Grants in Reproductive Biology |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2012 |
GNo | G0900113 |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | Y |
Sex Ratio and Sterility for Commercial animal production - round 5 Cluster$700,000
Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation
Funding body | CSIRO - Commonwealth Scientific and Industrial Research Organisation |
---|---|
Project Team | Laureate Professor John Aitken, Professor Eileen McLaughlin, Doctor Shaun Roman |
Scheme | National Research Flagship Cluster |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2011 |
GNo | G1000045 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Emeritus Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Conjoint Professor Rob Atkin, Associate Professor Clovia Holdsworth, Associate Professor Mark Baker, Associate Professor Nikki Verrills, Professor Gottfried Otting, Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G0190402 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Laser microdissection microscopy system for cell and development biology$350,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Lead |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G0190369 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Emeritus Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Conjoint Professor Rob Atkin, Associate Professor Clovia Holdsworth, Associate Professor Mark Baker, Associate Professor Nikki Verrills, Professor Gottfried Otting, Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000873 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Laser microdissection microscopy system for cell and development biology$215,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Equipment Grant |
Role | Lead |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000874 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Laser microdissection microscopy system for cell and development biology (HMRI contribution towards 2010 ARC LIEF grant)$50,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Equipment Grant |
Role | Lead |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000144 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Associate Professor Mark Baker, Laureate Professor John Aitken, Professor Adam McCluskey, Professor Brett Nixon, Emeritus Professor John Rostas, Professor Eileen McLaughlin |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000051 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000052 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20098 grants / $2,307,489
The role of the Anaphase-Promoting Complex activator Cdh1 in mammalian oocytes and aneuploidy$506,250
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Keith Jones, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2011 |
GNo | G0188850 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding body: ARC (Australian Research Council)
Characterization of the molecular basis of human sperm-oocyte interaction$474,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Brett Nixon, Professor Eileen McLaughlin, Dr M O'Bryan |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2011 |
GNo | G0188867 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
RNA binding proteins Musashi: role in foliculogenesis and oocyte development$402,750
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Dr Gary Hime |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2009 |
Funding Finish | 2011 |
GNo | G0188862 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Emeritus Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Associate Professor Nikki Verrills, Professor Brett Nixon, Doctor Shaun Roman, Professor Yong-Ling Ruan, Doctor Rick Thorne, Prof MIKE Calford |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2009 |
GNo | G0189038 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Aging eggs: understanding the molecular mechanisms of declining female fertility$79,489
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Conjoint Professor Keith Jones, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2010 |
GNo | G0189795 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding body: ARC (Australian Research Council)
LAS-4000 Chemiluminescence imaging system$25,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Professor Brett Nixon, Doctor Shaun Roman |
Scheme | Equipment Grant |
Role | Lead |
Funding Start | 2009 |
Funding Finish | 2009 |
GNo | G0189852 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
200811 grants / $11,077,403
Centre for Biotechnology and Development$8,999,866
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair |
Scheme | ARC Centres of Excellence |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2010 |
GNo | G0188624 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Feasibility of Humane Camel Management$1,032,504
Funding body: CRC for Invasive Animals
Funding body | CRC for Invasive Animals |
---|---|
Project Team | Laureate Professor John Aitken, Professor Eileen McLaughlin |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2018 |
GNo | G1100665 |
Type Of Funding | CRC - Cooperative Research Centre |
Category | 4CRC |
UON | Y |
Xenobiotics - ocidative stress in the mammalian ovary$362,625
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Brett Nixon, Doctor Shaun Roman |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2010 |
GNo | G0187620 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Centre for Biotechnology and Development$297,273
Funding body: NSW Department of State and Regional Development
Funding body | NSW Department of State and Regional Development |
---|---|
Project Team | Laureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair |
Scheme | ARC Centres of Excellence Partner Funding |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2010 |
GNo | G0189183 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
Cellular signals controlling oocyte activation$270,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Dr Darryl Russell, Dr Rebecca Robker |
Scheme | Discovery Projects |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2010 |
GNo | G0187536 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
CEF Admin Relief McLaughlin$50,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Hugh Dunstan, Professor Eileen McLaughlin |
Scheme | Career Enhancement Fellowship for Academic Women |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0189257 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Understanding the aetiology of human male infertility: Elucidation of the mechanisms underpinning sperm-egg interaction$21,650
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Brett Nixon, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0188465 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Characterization of the molecular basis of mouse sperm-oocyte interaction$18,285
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Brett Nixon, Professor Eileen McLaughlin |
Scheme | Near Miss Grant |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0188405 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Programmed mammalian oocyte activation: the production line model of primordial follicle development$14,700
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones |
Scheme | Pilot Grant |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0189084 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Personal career development within the University of Newcastle in 2008$8,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Career Enhancement Fellowship for Academic Women |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0188507 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
41st Annual Meeting of the Society for the Study of Reproduction $2,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0188937 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20079 grants / $669,867
FACSAria - Fluorescence activated cell sorter$300,000
Funding body: Cancer Institute NSW
Funding body | Cancer Institute NSW |
---|---|
Project Team | Associate Professor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff |
Scheme | Research Infrastructure Grants |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0187666 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$134,998
Funding body: Pestat Pty Ltd
Funding body | Pestat Pty Ltd |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken |
Scheme | Linkage Projects Partner Funding |
Role | Lead |
Funding Start | 2007 |
Funding Finish | 2010 |
GNo | G0188204 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Centre for Biotechnology and Development.$96,220
Funding body: NSW Department of State and Regional Development
Funding body | NSW Department of State and Regional Development |
---|---|
Project Team | Laureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland |
Scheme | ARC Centres of Excellence Partner Funding |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0187937 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Associate Professor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0188207 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
High speed/sensitivity CCD camera$30,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Conjoint Professor Robert Callister, Associate Professor Brett Graham, Professor Derek Laver, Professor Liz Milward, Associate Professor John Holdsworth |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0188196 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Cytokines and Folliculogenesis$20,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Near Miss Grant |
Role | Lead |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0187187 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Chemokines and spermatogenesis: roles of SDF-1 and CXCR-4 in the establishment of spermatogenesis$20,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Doctor Shaun Roman, Professor Brett Nixon |
Scheme | Near Miss Grant |
Role | Lead |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0187197 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Musashi 1 and 2 - role of RNA binding proteins in oocyte maturation$14,550
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Pilot Grant |
Role | Lead |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0186712 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
2007 SRB Annual Scientific Conference to be held in cnjunction with the ESA, Christchurch Convention Centre, New Zealand, 2/9/2007 - 5/9/2007$2,099
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0188058 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20064 grants / $573,055
PRC - Priority Research Centre for Reproductive Science$544,282
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Eileen McLaughlin, Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Professor Ian Symonds |
Scheme | Priority Research Centre |
Role | Investigator |
Funding Start | 2006 |
Funding Finish | 2013 |
GNo | G0186945 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Environmental impacts on female fertility and the menopause$17,273
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken, Doctor Shaun Roman |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2006 |
Funding Finish | 2006 |
GNo | G0186620 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Cytokine signalling pathway and ovarian folliculogenesis$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Dr Darryl Russell |
Scheme | Near Miss Grant |
Role | Lead |
Funding Start | 2006 |
Funding Finish | 2006 |
GNo | G0186066 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
American Society of Andrology 31st Annual Conference, April 8 -11, 2006$1,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2006 |
Funding Finish | 2006 |
GNo | G0186466 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20053 grants / $224,726
High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Peter Lewis, Conjoint Associate Professor Renate Griffith, Emeritus Professor Ray Rose, Emeritus Professor John Patrick, Associate Professor David McCurdy, Professor Adam McCluskey, Emeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor John Rostas, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Laureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor Roger Smith, Professor Alistair Sim, Associate Professor Paul Tooney, Dr Fraser Ross |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2005 |
Funding Finish | 2005 |
GNo | G0184185 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
SOCS-4 - modulation of cytokine and growth factor signalling in the mammalian ovary$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Associate Professor Renate Griffith |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2005 |
Funding Finish | 2005 |
GNo | G0184635 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Oolemmal receptors - the role of the tetraspanin CD151 in sperm-egg fusion$7,537
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Emeritus Professor Leonie Ashman |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2005 |
Funding Finish | 2005 |
GNo | G0184625 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20046 grants / $1,655,790
Multifunctional confocal laser scanning microscope with time resolved and two photon imaging and fluorescence correlation capabilities $579,230
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Prof Ewa Goldys |
Scheme | Unknown |
Role | Lead |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | |
Type Of Funding | Not Known |
Category | UNKN |
UON | N |
Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals$465,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien |
Scheme | Linkage Projects |
Role | Lead |
Funding Start | 2004 |
Funding Finish | 2006 |
GNo | G0183627 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$298,368
Funding body: Jurox
Funding body | Jurox |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien |
Scheme | Linkage Projects Partner Funding |
Role | Lead |
Funding Start | 2004 |
Funding Finish | 2006 |
GNo | G0183816 |
Type Of Funding | Not Known |
Category | UNKN |
UON | Y |
High-Speed Confocal Microscope Live Cell Recording System$274,692
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0183031 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
High-speed Confocal Microscope Live Cell Recording System$30,000
Funding body: University of New South Wales
Funding body | University of New South Wales |
---|---|
Project Team | Professor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) Partner Funding |
Role | Investigator |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0183841 |
Type Of Funding | Not Known |
Category | UNKN |
UON | Y |
Activation of the mammalian primordial follicle.$8,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0183443 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20034 grants / $9,492,900
Centre for Biotechnology and Development.$9,458,900
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland |
Scheme | ARC Centres of Excellence |
Role | Investigator |
Funding Start | 2003 |
Funding Finish | 2007 |
GNo | G0182214 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
The role of cytokines in the activation of the ovarian follicle.$17,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2003 |
Funding Finish | 2003 |
GNo | G0182197 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Oolemmal Proteomics - identification of oocyte cell surface protein complexes involved in sperm-egg interaction$12,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2003 |
Funding Finish | 2003 |
GNo | G0182320 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Profiling germ cell gene expression during spermatogonial differentiation$5,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2003 |
Funding Finish | 2003 |
GNo | G0182402 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20021 grants / $12,000
Oocyte selection in the female germ line - survival of the fittest?$12,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin |
Scheme | New Staff Grant |
Role | Lead |
Funding Start | 2002 |
Funding Finish | 2002 |
GNo | G0182024 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2007 | Honours | Musashi 1 and 2 RNA binding proteins role in mammalian folliculogenesis | Biol Sc Not Elsewhere Classifd, University of Newcastle | Principal Supervisor |
2007 | Honours | Chemokines and spermatogenesis | Biol Sc Not Elsewhere Classifd, University of Newcastle | Co-Supervisor |
2007 | Honours | Oxidiative stress and Folliculogenesis | Biol Sc Not Elsewhere Classifd, University of Newcastle | Principal Supervisor |
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2005 | Honours | Non genomic action of progesterone in human spermatozoa | Biol Sc Not Elsewhere Classifd, University of Newcastle | Principal Supervisor |
2005 | Honours | Xenobiotics Effects on mammalian folliculogenesis | Biol Sc Not Elsewhere Classifd, University of Newcastle | Co-Supervisor |
2004 | PhD | The role of Kit Ligand in primordial follicle activation in the juvenile rabbit ovary | Biol Sc Not Elsewhere Classifd, Australian National University | Consultant Supervisor |
2004 | Masters | A novel GTPase activating protein RhGAPs in the male gamete | Biol Sc Not Elsewhere Classifd, University of Newcastle | Co-Supervisor |
2004 | Honours | Supressors of Cytokine Signalling | Biol Sc Not Elsewhere Classifd, University of Newcastle | Principal Supervisor |
2003 | Honours | Characterisation of the sperm progesterone receptor | Biol Sc Not Elsewhere Classifd, University of Newcastle | Co-Supervisor |
News
Smoking and male fertility breakthrough finding
October 1, 2014
Professor Eileen McLaughlin
Position
Conjoint Professor
Biological Sciences
School of Environmental and Life Sciences
Faculty of Science
Focus area
Biological Sciences
Contact Details
eileen.mclaughlin@newcastle.edu.au | |
Phone | (02) 4921 5708 |
Mobile | 0419307514 |
Fax | (02) 4921 7949 |
Office
Room | LS4.38 |
---|---|
Building | Life Sciences. |
Location | Callaghan University Drive Callaghan, NSW 2308 Australia |