Dr Jacinta Martin

Dr Jacinta Martin

Research Associate

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

I am a Post-doctoral researcher in the Mothers and Babies Research Centre at the Hunter Medical Research Institute (HMRI) under the auspices of the Priority Research Centre for Reproductive Sciences. Together with Associate Professor Kirsty Pringle, my current research focuses on understanding what underscores a healthy and uncomplicated pregnancy

In the Pringle group we are examining how components of the circulating renin angiotensin system (RAS) (a hormone network that regulates blood pressure and fluid balance) functions to ensure healthy placental development. The placenta is critical for correct intrauterine development of the baby. Specifically it is responsible for determining the appropriate level of nutrition, oxygenation and maternal tolerance to the developing fetus. Unfortunately a large proportion of pregnancies are affected by complications arising from inadequate placentation (placenta formation), with significant adverse maternal and fetal outcomes. In particular preeclampsia, which affects 3-5% of all pregnancies in Australia, is responsible for over 60,000 maternal deaths annually. In addition, it may lead to preterm birth and fetal growth restriction with significance consequences for the health and wellbeing of these babies.  As such a better understanding of the pathophysiology of this syndrome is vital for early diagnosis and the development of new therapeutics to better treat preeclampsia. My role in the Pringle group is to develop innovate new laboratory models of preeclampsia so that we might uncover how key components of the RAS contribute to placental formation and the development of this pathology. Such a model would also enable us to uncover novel biomarkers of adverse pregnancy outcomes and to test new candidate therapies to prevent disease formation and progression in these women.

Previous Experience: I completed a Bachelor of Biotechnology (Honours) and a Doctor of Philosophy (PhD) under the supervision of Prof. Brett Nixon, Dr Elizabeth Bromfield and L. Prof. John Aitken at the University of Newcastle, Australia in 2019. My doctoral studies were focused on developing an understanding of the quality control mechanisms used by the egg and early embryo to ensure DNA quality. Specifically my work focused on the protective strategies afforded by efflux transporter proteins, DNA Repair pathways and the contribution of novel pro-survival factors on egg and embryo quality. These findings have provided a critical framework for the continued development of novel ways to preserve egg/embryo quality in the clinic and thus may contribute to improvements in contemporary assisted reproductive technologies such as in vitro fertilisation or IVF.  

My research has been recognised both nationally and internationally through publication in leading specialist and multidisciplinary journals, presentations meetings (Australian and America), invited seminars in the United Kingdom, America and Canada, in addition to the award of competitive peer-review awards. These include the Greaves Family Postgraduate Scholarship, the Jennie Thomas Medical Research Grant, two independent ‘Best Research Higher Degree Publication awards’ in 2016 and 2018 by the Faculty of Science and Information Technology and the University of Newcastle and the Frontiers in Reproduction Tuition Scholarship awarded by the Marine Biological Institute and the University of Chicago to attend the Frontiers in Reproduction’ research training course held at the Marine Biological Laboratory in Woods Hole, Massachusetts (USA).

My current research areas of interest include:

  1. Understanding the role of the early embryonic renin- angiotensin system (RAS) in successful placentation.
  2. Investigating the link between of mechanoenzymes in placental secretion and the pathophysiology of pre-eclampsia

I also maintain an active interest in gamete biology, maintenance of genomic integrity for oncofertilty management, embryogenesis and developmental biology.

 


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Biotechnology, University of Newcastle

Keywords

  • Cell Biology
  • Embryogenesis
  • Fertility
  • Gamete Biology
  • Oocyte
  • Placenta
  • Reproductive Biology

Languages

  • English (Mother)

Fields of Research

Code Description Percentage
060803 Animal Developmental and Reproductive Biology 30
111404 Reproduction 40
060802 Animal Cell and Molecular Biology 30

Professional Experience

UON Appointment

Title Organisation / Department
Research Associate University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Professional appointment

Dates Title Organisation / Department
1/01/2014 - 31/12/2016 Laboratory Technician

In my role at Hunter IVF, i was responsible for general laboratory maintenance, administrative services, data management, instrument sterilisation and media preparation, in addition to liaising with the patients, scientists, doctors and nursing staff.

IVF Australia (Hunter IVF Clinic)
Australia

Awards

Scholarship

Year Award
2015 Australian Post Graduate Scholarship
Australian Government and UON

Invitations

Speaker

Year Title / Rationale
2018 ‘How Oocytes and Embryos Protect their Genetic Integrity’.
2018 ‘DNA Repair and Protection in the Female Germline’
2017 ‘How oocytes and embryos protect their genetic integrity’
2017 ‘How Oocytes and Embryos Protect their Genetic Integrity’.
2017 ‘How Oocytes and Embryos Protect their Genetic Integrity’.
2016 ‘A PhD in reproductive science: Investigating oocyte and embryo genetic integrity’
2016 'Identification of a Key Role for Permeability Glycoprotein in Enhancing the Cellular Defence Mechanisms of the Fertilized Oocyte'

Teaching

Code Course Role Duration
SSS101X Sex, Science and Society
edX

Sex, Science and Society is an interdisciplinary look at the biological, technological, and social factors that influence human reproduction.
Online Moderator 1/01/0001 - 1/01/0001
BIOL1003 Professional Skills for the Biological Sciences
Faculty of Science | University of Newcastle
Students are introduced to the principles of scientific investigation and initiate the development of analytical and practical skills necessary for an active career in the diverse fields of modern biology. This equips the student for further studies in both lab-based biotechnology and field based environmental biology subjects. Students will be taught practical laboratory and field skills together with experimental design, data evaluation and technical report writing within the context of a number of exciting hands on biological investigations.
Demonstrator 1/06/2017 - 31/12/2017
BIOL2001 Molecular Laboratory Skills for the Biological Sciences
Faculty of Science | University of Newcastle
The course is designed to provide extensive training in the laboratory practices associated with biological research. Module 1 will focus on enzymes and biochemical reactions; Module 2 will focus on the chemistry of DNA; and Module 3 will focus on Immunochemistry and its application to biological research.
Demonstrator 25/02/2014 - 31/07/2018
BIOL2020 Animal Physiology and Development
Faculty of Science | University of Newcastle
The course provides a conceptual physiological framework for understanding the lives of animals at every level of organisation. It starts with essential chemical and physical laws that govern physiological processes in animals. These provide a foundation to understand the breadth of physiology. The course illustrates how the major physiological systems function and integrate to sustain the lives of animals. Contemporary physiological research is also considered in the course. Although the basic principles and mechanisms of major physiological systems form the central theme of this course, the importance of integrating knowledge across physiology disciplines with molecular biology, behaviour, ecology and other fields is also emphasised.
Demonstrator 24/02/2015 - 31/07/2015
BIOL3020 Reproductive Physiology and Development
Faculty of Science | University of Newcastle
This course provides a basic understanding of reproductive physiology and development in mammals for those students who wish to major in biology, cell and molecular biology, biotechnology or environmental science. The course focuses on: the processes involved in the production of gametes and how their development is synchronized in males and females to achieve fertilization. Within this context, the course considers: the processes involved in sexual differentiation; the specialization of the male and female gametes and how they achieve fertilization and subsequent development; and the reproductive strategies which have been adopted in order to achieve fertilization and birth at the most suitable times of the year. The roles of the endocrine system and signal transduction processes in controlling reproduction are examined. Topical examples of reproductive adaptations and technologies are considered, such as the evolution of reproduction in humans, the development of contraceptive methods for humans and pest animals, and clonal technologies.
Demonstrator 1/07/2016 - 31/12/2017
BIOL2002 Laboratory Skills in Biological Systems
Faculty of Science | University of Newcastle
The course is designed to provide extensive training in the laboratory practices associated with biological research. Module I will focus on microbial systems; Module II will focus on plant biology systems; and Module 3 will focus on animal biology systems.
Demonstrator 1/07/2018 - 31/12/2018
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (11 outputs)

Year Citation Altmetrics Link
2019 Nixon B, Johnston SD, Skerrett-Byrne DA, Anderson AL, Stanger SJ, Bromfield EG, et al., 'Modification of Crocodile Spermatozoa Refutes the Tenet That Post-testicular Sperm Maturation Is Restricted To Mammals.', Mol Cell Proteomics, 18 S59-S76 (2019)
DOI 10.1074/mcp.RA118.000904
Citations Web of Science - 1
Co-authors Brett Nixon, Matt Dun, Elizabeth Bromfield, Philip Hansbro
2019 Martin JH, Aitken RJ, Bromfield E, Cafe SL, Sutherland JM, Frost ER, et al., 'Investigation into the presence and functional significance of proinsulin C-peptide in the female germline', BIOLOGY OF REPRODUCTION, (2019)
Co-authors Elizabeth Bromfield, John Aitken, Brett Nixon, Jessie Sutherland, Tessa Lord
2019 Martin JH, Aitken RJ, Bromfield EG, Nixon B, 'DNA damage and repair in the female germline: contributions to ART.', Human Reproduction Update, 25 180-201 (2019) [C1]
DOI 10.1093/humupd/dmy040
Co-authors Brett Nixon, John Aitken, Elizabeth Bromfield
2018 Martin J, Bromfield EG, Aitken RJ, Lord T, Nixon B, 'Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes', Scientific Reports, 8 1-15 (2018) [C1]
DOI 10.1038/s41598-018-27892-2.
Citations Scopus - 3Web of Science - 3
Co-authors Brett Nixon, John Aitken, Elizabeth Bromfield, Tessa Lord
2018 Houston BJ, Nixon B, Martin JH, De Iuliis GN, Trigg NA, Bromfield EG, et al., 'Heat exposure induces oxidative stress and DNA damage in the male germ line', BIOLOGY OF REPRODUCTION, 98 593-606 (2018) [C1]
DOI 10.1093/biolre/ioy009
Citations Scopus - 5Web of Science - 3
Co-authors John Aitken, Elizabeth Bromfield, Geoffry DeiuliIs, Brett Nixon
2017 Kelleher AM, Khalaj K, Martin JH, Scaia MF, Wilson RL, 'Flourishing follicles: Overview of ovarioles.', Mol Reprod Dev, 84 1237 (2017)
DOI 10.1002/mrd.22858
2017 Martin JH, Bromfield EG, Aitken RJ, Nixon B, 'Biochemical alterations in the oocyte in support of early embryonic development', CELLULAR AND MOLECULAR LIFE SCIENCES, 74 469-485 (2017) [C1]
DOI 10.1007/s00018-016-2356-1
Citations Scopus - 5Web of Science - 5
Co-authors John Aitken, Brett Nixon, Elizabeth Bromfield
2016 Martin JH, Bromfield EG, Aitken RJ, Lord T, Nixon B, 'Data on the concentrations of etoposide, PSC833, BAPTA-AM, and cycloheximide that do not compromise the vitality of mature mouse oocytes, parthenogenetically activated and fertilized embryos', DATA IN BRIEF, 8 1215-1220 (2016)
DOI 10.1016/j.dib.2016.07.046
Citations Scopus - 4Web of Science - 4
Co-authors Elizabeth Bromfield, Brett Nixon, John Aitken, Tessa Lord
2016 Martin JH, Nixon B, Lord T, Bromfield EG, Aitken RJ, 'Identification of a key role for permeability glycoprotein in enhancing the cellular defense mechanisms of fertilized oocytes', DEVELOPMENTAL BIOLOGY, 417 63-76 (2016) [C1]
DOI 10.1016/j.ydbio.2016.06.035
Citations Scopus - 9Web of Science - 7
Co-authors Tessa Lord, John Aitken, Brett Nixon, Elizabeth Bromfield
2015 Lord T, Martin JH, Aitken RJ, 'Accumulation of Electrophilic Aldehydes During Postovulatory Aging of Mouse Oocytes Causes Reduced Fertility, Oxidative Stress, and Apoptosis', BIOLOGY OF REPRODUCTION, 92 (2015) [C1]
DOI 10.1095/biolreprod.114.122820
Citations Scopus - 20Web of Science - 21
Co-authors Tessa Lord, John Aitken
2015 Itman C, Bielanowicz A, Goh H, Lee Q, Fulcher AJ, Moody SC, et al., 'Murine Inhibin a-Subunit Haploinsufficiency Causes Transient Abnormalities in Prepubertal Testis Development Followed by Adult Testicular Decline.', Endocrinology, 156 2254-2268 (2015) [C1]
DOI 10.1210/en.2014-1555
Citations Scopus - 9Web of Science - 9
Show 8 more journal articles

Conference (2 outputs)

Year Citation Altmetrics Link
2019 Pringle KG, Mukherjee P, Morosin SK, Delforce SJ, Martin JH, Nixon B, 'Inhibition of Dynamin Reduces Soluble (Pro) renin Receptor (s(P) RR) Secretion from Human Trophoblasts.', REPRODUCTIVE SCIENCES, Paris, FRANCE (2019)
Co-authors Kirsty Pringle, Brett Nixon
2014 Lord T, Martin JH, Aitken RJ, 'ACCUMULATION OF 4-HYDROXYNONENAL DURING POST-OVULATORY AGEING OF MOUSE OOCYTES CAUSES REDUCED FERTILITY, OXIDATIVE STRESS AND APOPTOSIS.', FERTILITY AND STERILITY, Honolulu, HI (2014) [E3]
DOI 10.1016/j.fertnstert.2014.07.1118
Co-authors John Aitken, Tessa Lord
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Grants and Funding

Summary

Number of grants 16
Total funding $53,054

Click on a grant title below to expand the full details for that specific grant.


20193 grants / $16,700

Ignite EMCR Equipment Grant. $13,200

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Scheme Early and Mid-Career Equipment Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

2019 Faculty of Health and Medicine Conference Travel Grant.$2,000

Funding body: Faculty of Health and Medicine, University of Newcastle

Funding body Faculty of Health and Medicine, University of Newcastle
Scheme Faculty of Health and Medicine Conference Travel Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

Priority Research Centre for Reproductive Science Strategic Support Travel Grant Schemes$1,500

Funding body: Priority Research Centre in Reproductive Science

Funding body Priority Research Centre in Reproductive Science
Scheme PRC Strategic Support Travel Grant Scheme
Role Lead
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

20184 grants / $14,702

Jennie Thomas Medical Research Travel Grant $8,900

Funding body: Jennie Thomas - Philanthropic Donor

Funding body Jennie Thomas - Philanthropic Donor
Scheme Jennie Thomas Medical Research Travel Grant
Role Lead
Funding Start 2018
Funding Finish 2019
GNo
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON N

University of Newcastle-School of Biomedical Sciences and Pharmacy Researcher Equipment Grant $4,642

Funding body: University of Newcastle-School of Biomedical Sciences and Pharmacy

Funding body University of Newcastle-School of Biomedical Sciences and Pharmacy
Scheme University of Newcastle-School of Biomedical Sciences and Pharmacy Researcher Equipment Grant
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

Faculty of Science and IT Best Higher Degree Research Publication Award$1,000

Funding body: Faculty of Science and Information Technology The University of Newcastle

Funding body Faculty of Science and Information Technology The University of Newcastle
Scheme Faculty of Science and IT Best Higher Degree Research Publication Award (2018)
Role Lead
Funding Start 2018
Funding Finish 2018
GNo
Type Of Funding Internal
Category INTE
UON N

PhD2Postdoc Tuition Scholarship $160

Funding body: Faculty of Science and Information Technology The University of Newcastle

Funding body Faculty of Science and Information Technology The University of Newcastle
Scheme Tuition Scholarship
Role Lead
Funding Start 2018
Funding Finish 2018
GNo
Type Of Funding Internal
Category INTE
UON N

20176 grants / $18,652

Frontiers in Reproduction Tuition Scholarship$8,302

Funding body: Marine Biological Institute (MBL)

Funding body Marine Biological Institute (MBL)
Scheme Marine Biological Laboratory Tuition Scholarship for Frontiers in Reproduction
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding C3212 - International Not for profit
Category 3212
UON N

Greaves Family Postgraduate Scholarship in Medical Research $5,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Scheme Greaves Family Postgraduate Top Up Scholarship in Medical Research
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON N

Higher Degree Research International Travel Scholarship $2,600

Funding body: The University of Newcastle - Faculty of Science and Information Technology

Funding body The University of Newcastle - Faculty of Science and Information Technology
Scheme Higher Degree Research International Travel Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding Internal
Category INTE
UON N

Faculty of Science and Information technology, Head of School International Travel Scholarship$2,500

Funding body: Faculty of Science and Information Technology The University of Newcastle

Funding body Faculty of Science and Information Technology The University of Newcastle
Scheme Faculty of Science and Information Technology, International Travel Support Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding Internal
Category INTE
UON N

Conference Travel Grant to attend the 2017 ANZCDB Cell & Developmental Biology Meeting$150

Funding body: The Company of Biologists

Funding body The Company of Biologists
Scheme ANZSCB 2017 Conference Travel Grant
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding External
Category EXTE
UON N

The Australia and New Zealand Society for Cell and Developmental Biology-Cell & Developmental Biology Meeting 'Best Science image award'$100

Funding body: The Company of Biologists

Funding body The Company of Biologists
Scheme Conference Award
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding External
Category EXTE
UON N

20161 grants / $1,000

Faculty of Science and IT Best Higher Degree Research Publication Award $1,000

Funding body: Faculty of Science and Information Technology The University of Newcastle

Funding body Faculty of Science and Information Technology The University of Newcastle
Scheme Faculty of Science and IT Best Higher Degree Research Publication Award (2016)
Role Lead
Funding Start 2016
Funding Finish 2018
GNo
Type Of Funding Internal
Category INTE
UON N

20151 grants / $500

Excellence Award for First Year Presentation’ 20th Annual Research Higher Degree Conference$500

Funding body: Faculty of Science and Information Technology The University of Newcastle

Funding body Faculty of Science and Information Technology The University of Newcastle
Scheme Research Higher Degree Research Conference |Australia
Role Lead
Funding Start 2015
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

20131 grants / $1,500

Priority Research Centre in Reproductive Science: Molecular Basis of Sperm-Egg Interaction Vacation Scholarship$1,500

Funding body: Faculty of Science and Information Technology The University of Newcastle

Funding body Faculty of Science and Information Technology The University of Newcastle
Scheme Priority Research Centre in Reproductive Science Vacation Scholarship
Role Lead
Funding Start 2013
Funding Finish 2014
GNo
Type Of Funding Internal
Category INTE
UON N
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Research Supervision

Number of supervisions

Completed0
Current1

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2018 Honours The Effect of DNA Damage in Sperm on Fertilisation and Embryo Development Biological Sciences, Faculty of Science | University of Newcastle Co-Supervisor
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Dr Jacinta Martin

Position

Research Associate
Pringle Group/lab- Mothers and Babies research group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Email jacinta.martin@newcastle.edu.au
Phone (02) 4921 20327
Mobile N/A
Links Twitter
Research Networks
Research Networks

Office

Room HMR1 LVL 3 West (Work space: W3078)
Building HMRI LVL 3 West- W3-078
Location HMRI LVL 3 West- W3-078

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