Dr Geoffry De Iuliis

Dr Geoffry De Iuliis

Senior Lecturer

School of Environmental and Life Sciences (Reproductive Medicine)

Spotlighting male infertility to boost IVF success

By examining the biological factors of male infertility, Dr Geoffry De Iuliis’ work is helping to create new hope for millions of men and women struggling to conceive.

Image of Geoffrey De Iuliis

Infertility rates across the developed world are on the rise. Around one in six Australian couples will experience fertility problems, and Dr Geoffry De Iuliis warns that a decline in sperm count and quality is part of the problem.

To inform new solutions, Geoff and his research team are investigating the underlying causes of male infertility. This research, he explains, is more important than ever, especially as increasing numbers of Australians turn to assisted reproductive technologies like IVF for support.

“My research team asks questions such as, how and why does infertility occur in some men and how can we effectively treat those men?”

“By increasing our understanding of male infertility, we hope to develop better IVF practices, such as better ways of selecting the best possible cells to use in IVF. We also hope to be in a position where we can make recommendations on lifestyle that will improve fertility.”

World-renowned fertility research

With a strong background in chemistry, Geoff works alongside a highly skilled research team to examine the structure and biochemistry of the molecules that make up a sperm cell. The team then looks at how these cells might be damaged or break down in poor-quality sperm.

“I am very fortunate to have started my research career in a world-renowned reproductive science laboratory at the University of Newcastle, which continues to give me a fantastic platform to contribute knowledge on sperm cell biology.”

“So far, we have made great headway in understanding how sperm DNA can become damaged and the changes in biochemistry that degrade men’s sperm quality.”

Over the years, Geoff’s work has led to significant breakthroughs in our understanding of male factor infertility. For example, his work helped to clarify how chemical imbalances between free radicals and antioxidants in the body, known as “oxidative stress”, can lead to cell and tissue damage. Geoff suspects that oxidative stress is contributing to rising incidences of infertility within the male population.

“This stress, which is commonly seen in sub-fertile men, is responsible for damaging important molecules in sperm, including the paternal DNA.”

With a better understanding of the science behind male reproductive issues, Geoff and his team hope to aid global efforts in halting the increasing rates of male infertility and see more babies born healthy and strong.

“We want to reduce male infertility and improve outcomes for people undergoing assisted reproduction therapies. Our work also has important implications for ensuring the good health of children born from assisted reproductive procedures.”

As well as supporting improved human health, Geoff’s work also translates across to better fertility outcomes for some of our four-legged friends. The team’s reproductive science discoveries are also highly valued within the field of agriculture, providing insights to support healthy Australian livestock.

“Many processes of sperm biology are similar across mammalian species. This gives us the advantage of working with other species and contributing to the animal reproduction space, servicing both conservation and livestock programs.”

The mobile phone effect

For their most recent work, Geoff and his team are exploring how low energy radiation, such as the energy from mobile phones, can affect and damage sperm cells. Their research shows that this low energy radiation in the environment has a potential to impact health. However, Geoffry notes that more research is still needed.

“This low-level electromagnetic energy is the same medium that is used in mobile device communication, including 3, 4 and 5G and WiFi. In the laboratory, the effects we see from this energy on sperm are very clear; however, out in the environment, the effects are much more subtle. Hopefully this means that there are no risks to human health at all, but we can’t be certain.”

“Either way, we believe that people would rather know the truth. Which is why we are working at finding answers.”

Results from their work would not only help to progress reproductive health treatments, they would also serve as a useful model towards understanding how this type of energy may interact with other cells and tissues in general—something that is not currently known.

“Gaining this knowledge is critical towards informing any potential health risks for the public.”

Hope for prospective parents

Geoff’s research group works closely with IVF professionals from all over the world, allowing them to turn their ideas and learnings into real-world solutions for patients in the Hunter region, nationally and globally.

“As a born and bred Novocastrian, I am very proud to be part of Newcastle’s sustained global profile in reproductive science. I love the challenge of attacking a new scientific problem.”

Geoff shares that his work is also motivated by the personal experience of seeing friends and family struggle with infertility. For Geoff, there is no better feeling than knowing his research is helping to create new hope and new life.

“It must be incredibly difficult to find out that you may have trouble conceiving a child, and some of my friends have experienced this ordeal.”

“To be able to contribute, even in a small way, to improving fertility outcomes for people is pretty satisfying and keeps us pushing forward.”

Image of Geoffrey De Iuliis

Spotlighting male infertility to boost IVF success

By examining the biological factors of male infertility, Dr Geoffry De Iuliis’ work is helping to create new hope for millions of men and women struggling to conceive.Infertility rates across the developed world are on the rise. Around one in…

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Career Summary

Biography

Research Expertise

Geoff’s research interests involve sperm cell biology with specific focus on how reactive oxygen species negatively impact the male germ cell, including the processes which lead to protein and DNA damage. This damage has considerable impact on assisted reproduction technologies, leading to poorer reproductive outcomes for patients undergoing assisted conception therapies.  A new focus is on protein structure, using mass spectrometry and molecular modelling techniques to understand the function of critical proteins which may have importance as drugable targets, including avenues for novel contraceptives. His expertise includes sperm cell biology, analytical chemistry, bio-marker development, DNA damage detection and protein structure. Understanding the origins of protein and DNA damage in human spermatozoa and the consequences for human fertility, are his key research questions.


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle

Keywords

  • DNA Damage
  • Oxidative Stress
  • Proteomics
  • Sperm Cell Biology
  • Structural Biology

Fields of Research

Code Description Percentage
060112 Structural Biology (incl. Macromolecular Modelling) 20
111404 Reproduction 40
060199 Biochemistry and Cell Biology not elsewhere classified 40

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

Dates Title Organisation / Department
3/2/2014 - 23/2/2015 Postdoctoral Research Fellow The University of Newcastle - Faculty of Health and Medicine
School of Biomedical Sciences and Pharmacy
Australia
3/5/2004 - 1/1/2013 Postdoctoral Research Fellow The University of Newcastle - Faculty of Science and IT
School of Environmental and Life Sciences
Australia

Teaching

Code Course Role Duration
BIOL2020 Animal Physiology and Development
Faculty of Science and Information Technology, The University of Newcastle | Australia
Lecturer 26/2/2018 - 11/6/2018
BIOL1001 MOLECULES, CELLS AND ORGANISMS
Faculty of Science and Information Technology, The University of Newcastle | Australia
Lecturer 23/2/2015 - 6/7/2018
BIOL2001 Molecular Biology Laboratory Skills
Faculty of Science and Information Technology, The University of Newcastle | Australia
Lecturer 23/2/2015 - 6/7/2018
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (7 outputs)

Year Citation Altmetrics Link
2019 Aitken RJ, De Iuliis GN, Drevet JR, 'Role of Oxidative Stress in the Etiology of Male Infertility and the Potential Therapeutic Value of Antioxidants', Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction, Academic Press, London, UK 91-100 (2019) [B1]
DOI 10.1016/B978-0-12-812501-4.00010-9
Citations Scopus - 10
Co-authors John Aitken
2017 Nixon B, Bromfield EG, Cui J, De Iuliis GN, 'Heat shock protein A2 (HSPA2): regulatory roles in germ cell development and sperm', The Role of Heat Shock Proteins in Reproductive System Development and Function, Springer International Publishing, Cham, Switzerland 67-93 (2017) [B1]
DOI 10.1007/978-3-319-51409-3_4
Citations Scopus - 16Web of Science - 15
Co-authors Elizabeth Bromfield, Brett Nixon
2012 De Iuliis GN, King BV, Aitken RJ, 'Electromagnetic radiation and oxidative stress in the male germ line', Studies on Men's Health and Fertility, Springer, New York 3-20 (2012) [B1]
Citations Scopus - 2
Co-authors Bruce King, John Aitken
2012 Aitken RJ, De Iuliis GN, Baker MA, 'Direct methods for the detection of reactive oxygen species in human semen samples', Studies on Men's Health and Fertility, Springer, New York 275-299 (2012) [B1]
Citations Scopus - 4
Co-authors Mark Baker, John Aitken
2011 Aitken RJ, De Iuliis GN, 'Role of oxidative stress in the etiology of sperm DNA damage', Sperm Chromatin, Springer New York 277-293 (2011)
2010 Aitken RJ, Baker MA, De Iuliis GN, Nixon B, 'New insights into sperm physiology and pathology', Fertility Control, Springer, Berlin 99-115 (2010) [B1]
Citations Scopus - 55
Co-authors Brett Nixon, John Aitken, Mark Baker
2007 Aitken RJ, Roman SD, Baker MA, De Iuliis GN, 'Redox regulation of DNA damage in the male germ line', Male-Mediated Developmental Toxicity, Royal Society of Chemistry, London, United Kingdom 197-209 (2007) [B1]
Citations Scopus - 2Web of Science - 2
Co-authors Shaun Roman, John Aitken, Mark Baker
Show 4 more chapters

Journal article (57 outputs)

Year Citation Altmetrics Link
2020 Nixon B, Cafe SL, Eamens AL, De Iuliis GN, Bromfield EG, Martin JH, et al., 'Molecular insights into the divergence and diversity of post-testicular maturation strategies', Molecular and Cellular Endocrinology, 517 110955-110955 (2020) [C1]
DOI 10.1016/j.mce.2020.110955
Co-authors Elizabeth Bromfield, Brett Nixon, Matt Dun, Andy Eamens, David Skerrett-Byrne
2020 Gilbert J, De Iuliis GN, McCluskey A, Sakoff JA, 'A novel naphthalimide that selectively targets breast cancer via the arylhydrocarbon receptor pathway', Scientific Reports, 10 (2020) [C1]
DOI 10.1038/s41598-020-70597-8
Co-authors Jennette Sakoff, Adam Mccluskey
2020 Gibb Z, Griffin RA, Aitken RJ, De Iuliis GN, 'Functions and effects of reactive oxygen species in male fertility', Animal Reproduction Science, (2020)

© 2020 Elsevier B.V. Reactive oxygen species (ROS) are implicated in all aspects of cellular functions. While the importance of ROS as signalling molecules is well described, ROS ... [more]

© 2020 Elsevier B.V. Reactive oxygen species (ROS) are implicated in all aspects of cellular functions. While the importance of ROS as signalling molecules is well described, ROS are also associated with stress pathologies. Within the reproduction field, there are associations with reduced fertility as a result of lipid peroxidation, protein dysfunction, premature cell death and DNA damage which readily occur in spermatozoa. These oxidative insults can arise in vivo, or in vitro as a result of sperm storage, purification and processing. Following a brief description of the production, homeostasis and functions of ROS in mammalian sperm function, this review paper will focus on describing the predominant sources of ROS in the ejaculate, the effects of ROS on a cellular and molecular level, and the actions of ROS from the whole animal perspective. There is highlighting of some studies, which have revealed the mechanisms for these observations, along with some strategies to ameliorate or prevent the instigation of the oxidative stress cascade before irreversible damage to spermatozoa occurs.

DOI 10.1016/j.anireprosci.2020.106456
Co-authors Zamira Gibb, John Aitken
2020 Steffens Reinhardt L, Zhang X, Wawruszak A, Groen K, De Iuliis GN, Avery-Kiejda KA, 'Good Cop, Bad Cop: Defining the Roles of 40p53 in Cancer and Aging', Cancers, 12 (2020) [C1]
DOI 10.3390/cancers12061659
Citations Scopus - 1Web of Science - 1
Co-authors Kira Groen, Kelly Kiejda
2020 Dun MD, Mannan A, Rigby CJ, Butler S, Toop HD, Beck D, et al., 'Shwachman Bodian Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia', Leukemia, (2020)
DOI 10.1038/s41375-020-0814-0
Co-authors Matt Dun, Heather Murray, Hubert Hondermarck, Brett Nixon, Ryan Duchatel, Sam Faulkner, David Skerrett-Byrne, Anoop Enjeti, Nikki Verrills
2020 Aitken RJ, De Iuliis GN, Nixon B, 'The Sins of Our Forefathers: Paternal Impacts on De Novo Mutation Rate and Development.', Annu Rev Genet, (2020) [C1]
DOI 10.1146/annurev-genet-112618-043617
Co-authors John Aitken, Brett Nixon
2019 Sillar JR, Germon ZP, DeIuliis GN, Dun MD, 'The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia.', International Journal of Molecular Sciences, 20 (2019) [C1]
DOI 10.3390/ijms20236003
Citations Scopus - 12Web of Science - 12
Co-authors Matt Dun
2019 Nixon B, De Iuliis GN, Dun MD, Zhou W, Trigg NA, Eamens AL, 'Profiling of epididymal small non-protein-coding RNAs', Andrology, 7 669-680 (2019) [C1]
DOI 10.1111/andr.12640
Citations Scopus - 2Web of Science - 2
Co-authors Matt Dun, Andy Eamens, Brett Nixon
2019 Nixon B, De Iuliis GN, Hart HM, Zhou W, Mathe A, Bernstein IR, et al., 'Proteomic profiling of mouse epididymosomes reveals their contributions to post-testicular sperm maturation', Molecular and Cellular Proteomics, 18 S91-S108 (2019) [C1]
DOI 10.1074/mcp.RA118.000946
Citations Scopus - 25Web of Science - 26
Co-authors Matt Dun, Andrea Johns, David Skerrett-Byrne, Elizabeth Bromfield, Muhammad Jamaluddin, Brett Nixon
2019 Houston BJ, Nixon B, McEwan KE, Martin J, King BV, Aitken RJ, De Iuliis GN, 'Whole-body exposures to radiofrequency-electromagnetic energy can cause DNA damage in mouse spermatozoa via an oxidative mechanism', Scientific Reports, 9 (2019) [C1]
DOI 10.1038/s41598-019-53983-9
Citations Scopus - 3Web of Science - 2
Co-authors John Aitken, Bruce King, Brett Nixon
2019 Nixon B, Bernstein IR, Cafe SL, Delehedde M, Sergeant N, Anderson AL, et al., 'A Kinase Anchor Protein 4 is vulnerable to oxidative adduction in male germ cells', Frontiers in Cell and Developmental Biology, 7 (2019) [C1]
DOI 10.3389/fcell.2019.00319
Citations Scopus - 3Web of Science - 4
Co-authors Matt Dun, Andy Eamens, Tessa Lord, Brett Nixon, Elizabeth Bromfield
2019 Zhou W, Stanger SJ, Anderson AL, Bernstein IR, De Iuliis GN, McCluskey A, et al., 'Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions.', BMC biology, 17 35-35 (2019) [C1]
DOI 10.1186/s12915-019-0653-5
Citations Scopus - 11Web of Science - 13
Co-authors Eileen Mclaughlin, Brett Nixon, Matt Dun, Adam Mccluskey
2018 Zhou W, De Iuliis GN, Dun MD, Nixon B, 'Characteristics of the epididymal luminal environment responsible for sperm maturation and storage', Frontiers in Endocrinology, 9 (2018) [C1]
DOI 10.3389/fendo.2018.00059
Citations Scopus - 40Web of Science - 40
Co-authors Brett Nixon, Matt Dun
2018 Gilbert J, De Iuliis GN, Tarleton M, McCluskey A, Sakoff JA, '(Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile exhibits selective antitumor activity in breast cancer cell lines via the aryl hydrocarbon receptor pathway', Molecular Pharmacology, 93 168-177 (2018) [C1]
DOI 10.1124/mol.117.109827
Citations Scopus - 7
Co-authors Adam Mccluskey, Jennette Sakoff
2018 Zhou W, Sipilä P, De Iuliis G, Dun MD, Nixon B, 'Analysis of Epididymal Protein Synthesis and Secretion', Jove-Journal of Visualized Experiments, 138 (2018) [C1]
DOI 10.3791/58308
Citations Scopus - 6Web of Science - 4
Co-authors Brett Nixon, Matt Dun
2018 Houston BJ, Nixon B, King BV, Aitken RJ, De Iuliis GN, 'Probing the Origins of 1,800 MHz Radio Frequency Electromagnetic Radiation Induced Damage in Mouse Immortalized Germ Cells and Spermatozoa in vitro', FRONTIERS IN PUBLIC HEALTH, 6 (2018) [C1]
DOI 10.3389/fpubh.2018.00270
Citations Web of Science - 7
Co-authors Bruce King, Brett Nixon, John Aitken
2018 Walters JLH, De Iuliis G, Nixon B, Bromfield EG, 'Oxidative Stress in the Male Germline: A Review of Novel Strategies to Reduce 4-Hydroxynonenal Production', Antioxidants, 7 (2018) [C1]
DOI 10.3390/antiox7100132
Citations Scopus - 8Web of Science - 10
Co-authors Brett Nixon, Elizabeth Bromfield
2018 Walters JLH, De Iuliis GN, Dun MD, Aitken RJ, McLaughlin EA, Nixon B, Bromfield EG, 'Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.', Biology of reproduction, 98 784-794 (2018) [C1]
DOI 10.1093/biolre/ioy058
Citations Scopus - 10Web of Science - 12
Co-authors John Aitken, Matt Dun, Brett Nixon, Eileen Mclaughlin, Elizabeth Bromfield
2018 Mihalas BP, Bromfield EG, Sutherland JM, De Iuliis GN, McLaughlin EA, John Aitken R, Nixon B, 'Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity', Journal of Biological Chemistry, 293 18944-18964 (2018) [C1]
DOI 10.1074/jbc.RA118.005751
Citations Scopus - 11Web of Science - 12
Co-authors John Aitken, Jessie Sutherland, Elizabeth Bromfield, Brett Nixon, Eileen Mclaughlin
2018 Houston BJ, Nixon B, Martin JH, De Iuliis GN, Trigg NA, Bromfield EG, et al., 'Heat exposure induces oxidative stress and DNA damage in the male germ line', BIOLOGY OF REPRODUCTION, 98 593-606 (2018) [C1]
DOI 10.1093/biolre/ioy009
Citations Scopus - 30Web of Science - 27
Co-authors Brett Nixon, John Aitken, Elizabeth Bromfield
2017 Zhou W, De Iuliis GN, Turner AP, Reid AT, Anderson AL, McCluskey A, et al., 'Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis', BIOLOGY OF REPRODUCTION, 96 159-173 (2017) [C1]
DOI 10.1095/biolreprod.116.145433
Citations Scopus - 9Web of Science - 8
Co-authors Andrew Reid, Eileen Mclaughlin, Brett Nixon, Adam Mccluskey
2017 Mihalas BP, De Iuliis GN, Redgrove KA, McLaughlin EA, Nixon B, 'The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte', SCIENTIFIC REPORTS, 7 (2017) [C1]
DOI 10.1038/s41598-017-06372-z
Citations Scopus - 32Web of Science - 32
Co-authors Brett Nixon, Kate Redgrove, Eileen Mclaughlin
2017 Zhou W, Anderson AL, Turner AP, De Iuliis GN, McCluskey A, McLaughlin EA, Nixon B, 'Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.', Molecular Human Reproduction, 23 657-673 (2017) [C1]
DOI 10.1093/molehr/gax044
Citations Scopus - 6Web of Science - 6
Co-authors Eileen Mclaughlin, Adam Mccluskey, Brett Nixon
2016 Houston B, Nixon B, King BV, De Iuliis GN, Aitken RJ, 'The effects of radiofrequency electromagnetic radiation on sperm function', Reproduction, 152 R263-R276 (2016) [C1]
DOI 10.1530/REP-16-0126
Citations Scopus - 23Web of Science - 23
Co-authors John Aitken, Brett Nixon, Bruce King
2016 Aitken RJ, Muscio L, Whiting S, Connaughton HS, Fraser BA, Nixon B, et al., 'Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology', Biochemical Pharmacology, 121 78-96 (2016) [C1]
DOI 10.1016/j.bcp.2016.09.015
Citations Scopus - 15Web of Science - 11
Co-authors John Aitken, Brett Nixon
2014 Aitken RJ, Finnie JM, Muscio L, Whiting S, Connaughton HS, Kuczera L, et al., 'Potential importance of transition metals in the induction of DNA damage by sperm preparation media', Human Reproduction, 29 2136-2147 (2014) [C1]

© The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. STUDY QUESTION: What are the m... [more]

© The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. STUDY QUESTION: What are the mechanisms by which the preparation of spermatozoa on discontinuous density gradients leads to an increase in oxidative DNA damage? SUMMARY ANSWER: The colloidal silicon solutions that are commonly used to prepare human spermatozoa for assisted reproduction technology (ART) purposes contain metals in concentrations that promote free radical-mediated DNA damage. WHAT IS KNOWN ALREADY: Sporadic reports have already appeared indicating that the use of colloidal silicon-based discontinuous density gradients for sperm preparation is occasionally associated with the induction of oxidative DNA damage. The cause of this damage is however unknown. STUDY DESIGN, SIZE, DURATION: This study comprised a series of experiments designed to: (i) confirm the induction of oxidativeDNA damage in spermatozoa prepared on commercially available colloidal silicon gradients, (ii) compare the levels of damage observed with alterative sperm preparation techniques including an electrophoretic approach and (iii) determine the cause of the oxidative DNA damage and develop strategies for its prevention. The semen samples employed for this analysis involved a cohort of >50 unselected donors and at least three independent samples were used for each component of the analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS: The setting was a University biomedical science laboratory. The major techniques employed were: (i) flow cytometry to study reactive oxygen species generation, lipid peroxidation and DNA damage, (ii) computeraided sperm analysis to measure spermmovement and (iii) inductively coupled mass spectrometry to determine the elemental composition of sperm preparation media. MAIN RESULTS AND THE ROLE OF CHANCE: Oxidative DNA damage is induced in spermatozoa prepared on PureSperm® discontinuous colloidal silicon gradients (P < 0.001 versus repeated centrifugation) because this medium contains metals, particularly Fe, Al and Cu, which are known to promote free radical generation in the immediate vicinity of DNA. This damage can be significantly accentuated by reducing agents, such as ascorbate (P < 0.001) and inhibited by selective chelation (P < 0.001). This problem is not confined to PureSperm®; analysis of additional commercial sperm preparation media revealed that metal contamination is a relatively constant feature of such products. LIMITATIONS, REASONS FOR CAUTION: While the presence of metals, particularly transition metals, may exacerbate the levels of oxidative DNA damage seen in human spermatozoa, the significance of such damage has not yet been tested in suitably powered clinical trials. WIDER IMPLICATIONS OF THE FINDINGS: The results explain why the preparation of spermatozoa on discontinuous colloidal silicon gradients can result in oxidative DNA damage. The results are of immediate relevance to the development of safe, effective protocols for the preparation of spermatozoa for ART purposes. STUDY FUNDING/COMPETING INTEREST(S): The studywas funded by the Australian Health and Medical ResearchCouncil. One of the authors (R.J.A.) has had a consultantship with a biotechnology company, NuSep, interested in the development of electrophoretic methods of sperm preparation. He has no current financial interest in this area. None of the other authors have a conflict of interest to declare.

DOI 10.1093/humrep/deu204
Citations Scopus - 46Web of Science - 41
Co-authors Tony Rothkirch, John Aitken
2014 Aitken RJ, Smith TB, Jobling MS, Baker MA, De Iuliis GN, 'Oxidative stress and male reproductive health', Asian Journal of Andrology, 16 31-38 (2014) [C1]

One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cell... [more]

One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to proteins and lipids in the sperm plasma membrane. The origins of such oxidative stress appear to involve the sperm mitochondria, which have a tendency to generate high levels of superoxide anion as a prelude to entering the intrinsic apoptotic cascade. Unfortunately, these cells have very little capacity to respond to such an attack because they only possess the first enzyme in the base excision repair (BER) pathway, 8-oxoguanine glycosylase 1 (OGG1). The latter successfully creates an abasic site, but the spermatozoa cannot process the oxidative lesion further because they lack the downstream proteins (APE1, XRCC1) needed to complete the repair process. It is the responsibility of the oocyte to continue the BER pathway prior to initiation of S-phase of the first mitotic division. If a mistake is made by the oocyte at this stage of development, a mutation will be created that will be represented in every cell in the body. Such mechanisms may explain the increase in childhood cancers and other diseases observed in the offspring of males who have suffered oxidative stress in their germ line as a consequence of age, environmental or lifestyle factors. The high prevalence of oxidative DNA damage in the spermatozoa of male infertility patients may have implications for the health of children conceivedin vitro and serves as a driver for current research into the origins of free radical generation in the germ line. © 2014 AJA, SIMM & SJTU. All rights reserved.

DOI 10.4103/1008-682X.122203
Citations Scopus - 257Web of Science - 225
Co-authors Mark Baker, John Aitken
2013 De Iuliis GN, Newey RJ, King BV, Aitken RJ, 'Correction: Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro (PLoS ONE)', PLoS ONE, 8 (2013)
DOI 10.1371/annotation/9a8a0172-3850-4059-b852-72c330769c1b
Citations Scopus - 2
Co-authors Bruce King, John Aitken
2013 Aitken RJ, Bronson R, Smith TB, De Iuliis GN, 'The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies', Molecular Human Reproduction, 19 475-485 (2013) [C1]
DOI 10.1093/molehr/gat025
Citations Scopus - 92Web of Science - 79
Co-authors John Aitken
2013 Smith TB, De Iuliis GN, Lord T, Aitken RJ, 'The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line', Reproduction, 146 253-262 (2013) [C1]
DOI 10.1530/REP-13-0186
Citations Scopus - 31Web of Science - 25
Co-authors John Aitken, Tessa Lord
2013 Lewis SEM, Aitken RJ, Conner SJ, De Iuliis G, Evenson DP, Henkel R, et al., 'The impact of sperm DNA damage in assisted conception and beyond: Recent advances in diagnosis and treatment', Reproductive BioMedicine Online, 27 325-337 (2013) [C1]
DOI 10.1016/j.rbmo.2013.06.014
Citations Scopus - 130Web of Science - 117
Co-authors John Aitken
2013 Aitken RJ, Smith TB, Lord T, Kuczera L, Koppers AJ, Naumovski N, et al., 'On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid', Andrology, 1 192-205 (2013) [C1]
DOI 10.1111/j.2047-2927.2012.00056.x
Citations Scopus - 56Web of Science - 51
Co-authors Mark Baker, John Aitken, Tessa Lord
2012 Aitken RJ, Gibb Z, Mitchell LA, Lambourne SR, Connaughton HS, De Iuliis GN, 'Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols', Biology of Reproduction, 87 1-11 (2012) [C1]
Citations Scopus - 111Web of Science - 101
Co-authors John Aitken, Zamira Gibb
2012 Aitken RJ, Whiting SJ, De Iuliis GN, McClymont SL, Mitchell LA, Baker MA, 'Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase', Journal of Biological Chemistry, 287 33048-33060 (2012) [C1]
DOI 10.1074/jbc.M112.366690
Citations Scopus - 127Web of Science - 121
Co-authors John Aitken, Mark Baker
2012 Aitken RJ, De Iuliis GN, Gibb Z, Baker MA, 'The Simmet lecture: New horizons on an old landscape - oxidative stress, DNA damage and apoptosis in the male germ line', Reproduction in Domestic Animals, 47 7-14 (2012) [C2]
Citations Scopus - 37Web of Science - 37
Co-authors Zamira Gibb, Mark Baker, John Aitken
2011 Aitken RJ, Mitchell L, De Iuliis GN, 'Reply: M540 bodies interfere with TUNEL analyses in human semen samples', HUMAN REPRODUCTION, 26 729-730 (2011) [C3]
DOI 10.1093/humrep/deq371
Citations Scopus - 1
Co-authors John Aitken
2010 Aitken RJ, De Iuliis GN, Finnie JM, Hedges A, McLachlan RI, 'Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: Development of diagnostic criteria', Human Reproduction, 25 2415-2426 (2010) [C1]
DOI 10.1093/humrep/deq214
Citations Scopus - 228Web of Science - 208
Co-authors John Aitken
2010 Mitchell LA, De Iuliis GN, Aitken RJ, 'The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: Development of an improved methodology', International Journal of Andrology, 34 2-13 (2010) [C1]
DOI 10.1111/j.1365-2605.2009.01042.x
Citations Scopus - 109Web of Science - 109
Co-authors John Aitken
2010 Aitken RJ, De Iuliis GN, 'On the possible origins of DNA damage in human spermatozoa', Molecular Human Reproduction, 16 3-13 (2010) [C1]
DOI 10.1093/molehr/gap059
Citations Scopus - 321Web of Science - 299
Co-authors John Aitken
2009 De Iuliis GN, Newey RJ, King BV, Aitken RJ, 'Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro', PLoS ONE, 4 e6446 (2009) [C1]
DOI 10.1371/journal.pone.0006446
Citations Scopus - 270Web of Science - 217
Co-authors Bruce King, John Aitken
2009 Bennetts LE, De Iuliis GN, Nixon B, Kime M, Zelski K, McVicar CM, et al., 'Impact of Estrogenic Compounds on DNA Integrity in Human Spermatozoa: Evidence for Cross-Linking and Redox Cycling Activities', JOURNAL OF UROLOGY, 181 914-915 (2009) [C1]
Citations Scopus - 73Web of Science - 71
Co-authors John Aitken, Brett Nixon
2009 De Iuliis GN, Thomson LK, Mitchell LA, Read JM, Koppers AJ, Hedges A, et al., 'DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress', Biology of Reproduction, 81 517-524 (2009) [C1]
DOI 10.1095/biolreprod.109.076836
Citations Scopus - 230Web of Science - 232
Co-authors John Aitken, Brett Nixon
2009 Czarny NA, Harris MS, De Iuliis GN, Rodger JC, 'Acrosomal integrity, viability, and DNA damage of sperm from dasyurid marsupials after freezing or freeze drying', Theriogenology, 72 817-825 (2009) [C1]
DOI 10.1016/j.theriogenology.2009.05.018
Citations Scopus - 17Web of Science - 14
Co-authors John Rodger, Merrilee Harris
2009 Aitken RJ, De Iuliis GN, McLachlan RI, 'Biological and clinical significance of DNA damage in the male germ line', International Journal of Andrology, 32 46-56 (2009) [C1]
DOI 10.1111/j.1365-2605.2008.00943.x
Citations Scopus - 255Web of Science - 236
Co-authors John Aitken
2009 Thomson LK, Fleming SD, Aitken RJ, De Iuliis GN, Zieschang JA, Clark AM, 'Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis', Human Reproduction, 24 2061-2070 (2009) [C1]
DOI 10.1093/humrep/dep214
Citations Scopus - 243Web of Science - 228
Co-authors John Aitken
2008 Koppers AJ, De Iuliis GN, Read JM, McLaughlin EA, Aitken RJ, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
DOI 10.1210/jc.2007-2616
Citations Scopus - 360Web of Science - 339
Co-authors Eileen Mclaughlin, John Aitken
2007 Aitken RJ, Wingate JK, De Iuliis GN, McLaughlin EA, 'Analysis of lipid peroxidation in human spermatozoa using BODIPY C11', Molecular Human Reproduction, 13 203-211 (2007) [C1]
DOI 10.1093/molehr/gal119
Citations Scopus - 122Web of Science - 115
Co-authors John Aitken, Eileen Mclaughlin
2007 Aitken RJ, De Iuliis GN, 'Value of DNA integrity assays for fertility evaluation', Society for Reproduction and Fertility Supplement, 65 81-92 (2007) [C1]
Citations Scopus - 67
Co-authors John Aitken
2007 Aitken RJ, De Iuliis GN, 'Origins and consequences of DNA damage in male germ cells', Reproductive Biomedicine Online, 14 727-733 (2007) [C1]
DOI 10.1016/S1472-6483(10)60676-1
Citations Scopus - 273Web of Science - 264
Co-authors John Aitken
2006 De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
DOI 10.1210/jc.2005-2711
Citations Scopus - 106Web of Science - 101
Co-authors Eileen Mclaughlin, John Aitken
2006 Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA, 'Cis-unsaturated Fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 4154-4163 (2006) [C1]
DOI 10.1210/jc.2006-1309
Citations Scopus - 123Web of Science - 116
Co-authors Eileen Mclaughlin, John Aitken
2006 McCann N, De Iuliis GN, Lawrance GA, Maeder M, Schrader K, Moore P, 'Mono- and dinuclear copper(II) complexes of pendant-arm macrocyclic polyamines: Synthesis, characterization and investigation as hydrolytic cleavage agents for DNA', Inorganic Reaction Mechanisms, 6 91-112 (2006) [C1]
DOI 10.1515/IRM.2006.6.2.91
Citations Scopus - 3Web of Science - 3
Co-authors Marcel Maeder, Geoffrey Lawrance
2004 Robertson MJ, De Iuliis GN, Maeder M, Lawrance GA, 'Metal-directed synthesis of a chiral acyclic pentaamine and pendant-arm macrocyclic hexaamine derived from an amino acid', Inorganica Chimica Acta, 357 557-570 (2004) [C1]
DOI 10.1016/j.ica.2003.08.018
Citations Scopus - 13Web of Science - 13
Co-authors Marcel Maeder, Geoffrey Lawrance
2003 Comba P, De Iuliis GN, Lawrance GA, Luther S, Maeder M, Nolan AL, et al., 'Geometrical isomerism in octahedral complexes arising from the presence of a fused ring on a triaza macrocycle', Dalton Transactions, 2188-2193 (2003) [C1]
DOI 10.1039/b303515h
Citations Scopus - 7Web of Science - 6
Co-authors Geoffrey Lawrance, Marcel Maeder
2003 De Iuliis GN, Lawrance GA, Bernhardt PV, 'DNA cleavage with dinuclear metal complexes of ligands with varying flexibility', Journal of Inorganic Biochemistry, 96 158 (2003) [C3]
Co-authors Geoffrey Lawrance
2002 De Iuliis GN, Lawrance GA, Wilson N, 'Metal complex-promoted cleavage of RNA dimers and trimers; electrospray ionisation mass spectrometry evidence for cleavage', Inorganic Reaction Mechanisms, 4 169-186 (2002) [C1]
Citations Web of Science - 1
Co-authors Geoffrey Lawrance
2000 De Iuliis GN, Lawrance GA, Fieuw-Makaroff S, 'Superior hydrolytic DNA cleavage by a dinuclear copper(II) N4S4-donor complex compared with a mononuclear N2S2-donor close analogue', INORGANIC CHEMISTRY COMMUNICATIONS, 3 307-309 (2000) [C1]
Citations Scopus - 38Web of Science - 31
Co-authors Geoffrey Lawrance
Show 54 more journal articles

Conference (17 outputs)

Year Citation Altmetrics Link
2019 De Iuliis G, Houston B, Miller K, 'Calling all sperm mobile phone radiation and its effects on sperm health', Melbourne, Victoria, Australia (2019)
2018 De Iuliis GN, Milhalas BP, Redgrove KA, McLaughlin EA, Nixon B, 'Mechanisms responsible for the age-related decline in oocyte quality: the use of antioxidants to halt the aging process in eggs', Hunter Valley, NSW (2018)
Co-authors Kate Redgrove, Eileen Mclaughlin
2017 De Iuliis G, Nixon B, Aitken R, 'Causes and consequences of oxidative damage in the male germ line', Copenhagen, Denmark (2017)
Co-authors John Aitken
2016 De Iuliis GN, Cui J, Bromfield E, Nixon B, 'Oxidative Stress-Induced Protein Modifications in Spermatozoa and Consequences for Sperm-Oocyte Recognition', Gold Coast, Australia (2016)
2014 De Iuliis GN, Verrills NM, Dun MD, 'IN SILICO ANALYSIS OF THE TARGETS OF SMALL-MOLECULE, ANTI-CANCER COMPOUNDS FOR IMPROVED CANCER THERAPEUTICS', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Matt Dun, Nikki Verrills
2014 Gilbert J, Dun MD, De Iuliis GN, McCluskey A, Sakoff JA, 'SELECTIVELY TARGETING BREAST CANCER CELLS VIA CHECKPOINT ACTIVATION', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Matt Dun, Jennette Sakoff, Adam Mccluskey
2009 Aitken RJ, De Iuliis GN, Koppers AJ, 'OXIDATIVE STRESS AND SPERMATOZOA HEALTH', JOURNAL OF ANDROLOGY, Barcelona, SPAIN (2009) [E3]
Co-authors John Aitken
2009 de Iuliis GN, Newey RJ, King BV, Aitken RJ, 'MOBILE PHONE RADIATION INDUCES REACTIVE OXYGEN SPECIES PRODUCTION AND DNA DAMAGE IN HUMAN SPERMATOZOA IN VITRO', JOURNAL OF ANDROLOGY, Barcelona, SPAIN (2009) [E3]
Co-authors John Aitken, Bruce King
2008 De Iuliis GN, Nixon K, Aitken RJ, 'Estrogenic compounds induce oxidative stress in human spermatozoa: Implications for DNA integrity and fertilization success', Biology of Reproduction, Kailua-Kona, Hawaii (2008) [E3]
Co-authors John Aitken
2008 Aitken RJ, De Iuliis GN, Nixon B, Roman SD, 'Causes and clinical significance of DNA damage in the male germ line', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authors Shaun Roman, John Aitken
2008 Aitken R, Do Iuliis G, Nixon B, Roman S, 'Causes and clinical significance of DNA damage in the male germ line', BIOLOGY OF REPRODUCTION, Kona, HI (2008) [E3]
Co-authors Shaun Roman, John Aitken
2007 Schjenken JE, Stanger SJ, Smith V, Douglas A, De Iuliis GN, Depaz I, et al., 'Expression and activity of phase 1 detoxifying enzymes in the male sperm line of the mouse', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authors Shaun Roman, John Aitken
2007 Aitken RJ, De Iuliis GN, 'Midnight's broken toll: The male germ cell and its role in the aetiology of genetic disease', Early Human Development, Perth, W.A. (2007) [E3]
Co-authors John Aitken
2007 De Iuliis GN, Zelski K, Aitken RJ, 'The Impact of Estrogenic Compounds on DNA Integrity in the Male Germ Line', Endocrine Society of Australia (ESA) & Society for Reproductive Biology (SRB) Annual Scientific Meeting. Proceedings, Christchurch, New Zealand (2007) [E3]
Co-authors John Aitken
2006 Aitken RJ, De Iuliis GN, 'Value of DNA integrity assays for fertility evaluation', Abstracts, Madrid, Spain (2006) [E3]
Co-authors John Aitken
2004 De Iuliis GN, MacDougall IJA, Griffith R, 'Molecular modelling of alpha 1b and alpha 1d adrenoceptors and investigations into the effects of water and adrenaline', MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]
2003 De Iuliis GN, Griffith R, 'Molecular Dynamics Studies On A Model Of The a1b-Adrenergic Receptor: The Effects Of Water, Adrenaline And Site Directed Mutagenesis', TOMECS International Symposium AIMECS 03 Post Symposium Meeting Abstracts, Sunforte, Japan (2003) [E3]
Show 14 more conferences
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Grants and Funding

Summary

Number of grants 7
Total funding $2,184,361

Click on a grant title below to expand the full details for that specific grant.


20211 grants / $325,846

Pregnancy and Reproduction Program$325,846

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Laureate Professor Roger Smith, Laureate Professor John Aitken, Professor Craig Pennell, Professor Brett Nixon, Associate Professor Kirsty Pringle, Associate Professor Mark Baker, Professor Jon Hirst, Doctor Elizabeth Bromfield, Doctor Jonathan Paul, Doctor Geoffry De Iuliis, Doctor Yogavijayan Kandasamy, Doctor Jessie Sutherland, Professor Lee Smith
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2021
Funding Finish 2021
GNo G2001363
Type Of Funding C2220 - Aust StateTerritoryLocal - Other
Category 2220
UON Y

20201 grants / $1,319,338

Utilising male fertility as a biomarker of health to understand the biological effects of PFAS$1,319,338

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Brett Nixon, Doctor Brett Turner, Doctor Brett Turner, Doctor Geoffry De Iuliis, Doctor Geoffry De Iuliis, Dr Bradley Clarke, Doctor Shaun Roman, Doctor Shaun Roman, Doctor Matt Dun, Doctor Matt Dun, Doctor Andy Eamens, Doctor Andy Eamens, Dr Mark Green, Dr Mark Green, Dr Bradley Clarke
Scheme Targeted Call for Research - Per and Poly-Fluoroalkylated Substances (PFAS)
Role Investigator
Funding Start 2020
Funding Finish 2023
GNo G1900626
Type Of Funding C1100 - Aust Competitive - NHMRC
Category 1100
UON Y

20192 grants / $490,177

Utilising the male germline to define our understanding of the biological effects of radio frequency electromagnetic energy$435,307

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Geoffry De Iuliis, Dr King Yuk Chan, chan, King Yuk, Professor Brett Nixon, Professor Rodica Ramer, Ramer, Rodica
Scheme Project Grant
Role Lead
Funding Start 2019
Funding Finish 2021
GNo G1800050
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

IVOS II-Animal-basic for computer assisted analysis of sperm from multiple species$54,870

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Mark Baker, Doctor Zamira Gibb, Doctor Aleona Swegen, Doctor Geoffry De Iuliis, Doctor Benjamin Curry
Scheme Equipment Grant
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1900305
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

20171 grants / $20,000

The quantitative analysis of the oxidative stress biomarker 8-OHG in infertile men$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Geoffry De Iuliis
Scheme Project Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1700989
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

20131 grants / $14,000

NucleoCounter SP100$14,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling, Doctor Zamira Gibb, Mr Nenad Naumovski
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201175
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20121 grants / $15,000

BMG SPECTROstar Nano$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Associate Professor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100971
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y
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Research Supervision

Number of supervisions

Completed3
Current5

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2019 PhD The Development of Novel Materials for the Selection of High Quality Spermatozoa and the Assessment of Cellular Oxidative Status Through the Analysis of Lipid Peroxide Metabolites PhD (Biological Sciences), Faculty of Science, The University of Newcastle Principal Supervisor
2019 Masters The Application of Chemical Cross-linking Mass Spectrometry towards Understanding the Protein Interactome in Human Spermatozoa M Philosophy (Biological Sc), Faculty of Science, The University of Newcastle Principal Supervisor
2018 PhD Targeting Oxidative Stress for the Improved Treatment of Acute Myeloid Leukaemia PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Epididymosomes and Environmental Epigenetic Inheritance PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
2017 PhD Regulation of Sperm Function and Oxidative Stress by Lipoxygenase Enzymes PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2019 PhD Functional Characterisation of Dynamin in Spermatozoa Epididymal Maturation and Acrosomal Exocytosis PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
2018 PhD Investigating the Effects of Mobile Phone Radiation and Heating on Spermatogenesis and Sperm Function PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
2016 Masters Oxidative Stress, Sperm DNA Fragmentation and Outcome of Assisted Reproduction Medical Science, University of Western Sydney Co-Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 69
New Zealand 6
United Kingdom 3
France 2
United States 2
More...
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News

Effects of Wi-fi on Human Cells

October 9, 2019

Faculty research examines the impact of low-frequency radio waves on human cells.

New hope to stop the female biological clock

July 25, 2017

UON researchers have identifyied an antioxidant which has demonstrated potential to halt the aging process in female eggs.

Dr Geoffry De Iuliis

Position

Senior Lecturer
School of Environmental and Life Sciences
Faculty of Science

Focus area

Reproductive Medicine

Contact Details

Email geoffry.deiuliis@newcastle.edu.au
Phone (02) 4921 7295
Fax (02) 4921 6308
Links Research Networks
UoN Blogs

Office

Room LS4-47
Building Life Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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