Dr Geoffry De Iuliis

Dr Geoffry De Iuliis

Senior Lecturer

School of Environmental and Life Sciences (Reproductive Medicine)

Career Summary

Biography

Research Expertise

Geoff’s research interests involve sperm cell biology with specific focus on how reactive oxygen species negatively impact the male germ cell, including the processes which lead to protein and DNA damage. This damage has considerable impact on assisted reproduction technologies, leading to poorer reproductive outcomes for patients undergoing assisted conception therapies.  A new focus is on protein structure, using mass spectrometry and molecular modelling techniques to understand the function of critical proteins which may have importance as drugable targets, including avenues for novel contraceptives. His expertise includes sperm cell biology, analytical chemistry, bio-marker development, DNA damage detection and protein structure. Understanding the origins of protein and DNA damage in human spermatozoa and the consequences for human fertility, are his key research questions.


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle

Keywords

  • DNA Damage
  • Oxidative Stress
  • Proteomics
  • Sperm Cell Biology
  • Structural Biology

Fields of Research

Code Description Percentage
060112 Structural Biology (incl. Macromolecular Modelling) 20
111404 Reproduction 40
060199 Biochemistry and Cell Biology not elsewhere classified 40

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

Dates Title Organisation / Department
3/02/2014 - 23/02/2015 Postdoctoral Research Fellow The University of Newcastle - Faculty of Health and Medicine
School of Biomedical Sciences and Pharmacy
Australia
3/05/2004 - 1/01/2013 Postdoctoral Research Fellow The University of Newcastle - Faculty of Science and IT
School of Environmental and Life Sciences
Australia

Teaching

Code Course Role Duration
BIOL1001 MOLECULES, CELLS AND ORGANISMS
Faculty of Science and Information Technology, The University of Newcastle | Australia
Lecturer 23/02/2015 - 6/07/2018
BIOL2001 Molecular Biology Laboratory Skills
Faculty of Science and Information Technology, The University of Newcastle | Australia
Lecturer 23/02/2015 - 6/07/2018
BIOL2020 Animal Physiology and Development
Faculty of Science and Information Technology, The University of Newcastle | Australia
Lecturer 26/02/2018 - 11/06/2018
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (7 outputs)

Year Citation Altmetrics Link
2018 Aitken RJ, De Iuliis GN, Drevet JR, 'Role of Oxidative Stress in the Etiology of Male Infertility and the Potential Therapeutic Value of Antioxidants', Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction, Academic Press, 125 London Wall, London EC2Y 5AS, United Kingdom 91-98 (2018)
Co-authors John Aitken
2017 Nixon B, Bromfield EG, Cui J, De Iuliis GN, 'Heat shock protein A2 (HSPA2): regulatory roles in germ cell development and sperm', The Role of Heat Shock Proteins in Reproductive System Development and Function, Springer International Publishing, Cham, Switzerland 67-93 (2017) [B1]
DOI 10.1007/978-3-319-51409-3_4
Citations Scopus - 7Web of Science - 5
Co-authors Brett Nixon, Elizabeth Bromfield
2012 De Iuliis GN, King BV, Aitken RJ, 'Electromagnetic radiation and oxidative stress in the male germ line', Studies on Men's Health and Fertility, Springer, New York 3-20 (2012) [B1]
Citations Scopus - 1
Co-authors John Aitken, Bruce King
2012 Aitken RJ, De Iuliis GN, Baker MA, 'Direct methods for the detection of reactive oxygen species in human semen samples', Studies on Men's Health and Fertility, Springer, New York 275-299 (2012) [B1]
Citations Scopus - 2
Co-authors John Aitken, Mark Baker
2011 Aitken RJ, De Iuliis GN, 'Role of oxidative stress in the etiology of sperm DNA damage', Sperm Chromatin, Springer New York 277-293 (2011)
2010 Aitken RJ, Baker MA, De Iuliis GN, Nixon B, 'New insights into sperm physiology and pathology', Fertility Control, Springer, Berlin 99-115 (2010) [B1]
Citations Scopus - 51
Co-authors John Aitken, Brett Nixon, Mark Baker
2007 Aitken RJ, Roman SD, Baker MA, De Iuliis GN, 'Redox regulation of DNA damage in the male germ line', Male-Mediated Developmental Toxicity, Royal Society of Chemistry, London, United Kingdom 197-209 (2007) [B1]
Citations Scopus - 2Web of Science - 2
Co-authors Shaun Roman, John Aitken, Mark Baker
Show 4 more chapters

Journal article (48 outputs)

Year Citation Altmetrics Link
2019 Nixon B, De Iuliis GN, Hart HM, Zhou W, Mathe A, Bernstein IR, et al., 'Proteomic profiling of mouse epididymosomes reveals their contributions to post-testicular sperm maturation', Molecular and Cellular Proteomics, 18 S91-S108 (2019) [C1]
DOI 10.1074/mcp.RA118.000946
Citations Scopus - 5Web of Science - 6
Co-authors Elizabeth Bromfield, Brett Nixon, Muhammad Jamaluddin, Matt Dun, Andrea Johns
2019 Zhou W, Stanger SJ, Anderson AL, Bernstein IR, De Iuliis GN, McCluskey A, et al., 'Mechanisms of tethering and cargo transfer during epididymosome-sperm interactions.', BMC biology, 17 35-35 (2019) [C1]
DOI 10.1186/s12915-019-0653-5
Citations Scopus - 1Web of Science - 1
Co-authors Eileen Mclaughlin, Adam Mccluskey, Brett Nixon, Matt Dun
2019 Nixon B, De Iuliis GN, Dun MD, Zhou W, Trigg NA, Eamens AL, 'Profiling of epididymal small non-protein-coding RNAs', Andrology, 7 669-680 (2019)

© 2019 American Society of Andrology and European Academy of Andrology Background: Our understanding of epididymal physiology and function has been transformed over the three deca... [more]

© 2019 American Society of Andrology and European Academy of Andrology Background: Our understanding of epididymal physiology and function has been transformed over the three decades in which the International Meeting Series on the Epididymis has been hosted. This transformation has occurred along many fronts, but among the most significant advances has been the unexpected discovery of the diversity of small non-protein-coding RNAs (sRNAs) expressed in the epididymal epithelium and differentially accumulated in the luminal population of spermatozoa. Objectives: Here we survey recent literature pertaining to profiling the sRNA landscape of the mammalian epididymis with the goal of demonstrating the contribution that these key regulatory elements, and their associated pathways, make to epididymal physiology and sperm maturation. Results and discussion: High throughput sequencing strategies have fueled an unprecedented advance in our understanding of RNA biology. In the last decade, such high throughput profiling tools have been increasingly applied to study the mammalian epididymis, presaging the discovery of diverse classes of sRNA expressed along the length of the tract. Among the best studied sRNA classes are the microRNAs (miRNA), a sRNA species shown to act in concert with endocrine signals to fine-tune the segmental patterning of epididymal gene expression. In addition to performing this homeostatic role, epithelial cell-derived sRNAs also selectively accumulate into the epididymosomes and spermatozoa that occupy the duct lumen. This exciting discovery alludes to a novel form of intracellular communication that contributes to the establishment of the sperm epigenome and its modification under conditions of paternal stress. Conclusion: Compelling literature has identified sRNAs as a crucial regulatory tier that allows the epididymis to fulfill its combined roles of sperm transport, maturation, and storage. Continued research in this emerging field will contribute to our growing understanding of the etiology of male factor infertility and potentially allow for the future design of rational therapeutic options for these individuals.

DOI 10.1111/andr.12640
Co-authors Matt Dun, Andy Eamens, Brett Nixon
2018 Zhou W, De Iuliis GN, Dun MD, Nixon B, 'Characteristics of the epididymal luminal environment responsible for sperm maturation and storage', Frontiers in Endocrinology, 9 (2018) [C1]
DOI 10.3389/fendo.2018.00059
Citations Scopus - 15Web of Science - 14
Co-authors Brett Nixon, Matt Dun
2018 Gilbert J, De Iuliis GN, Tarleton M, McCluskey A, Sakoff JA, '(Z)-2-(3,4-dichlorophenyl)-3-(1H-pyrrol-2-yl)acrylonitrile exhibits selective antitumor activity in breast cancer cell lines via the aryl hydrocarbon receptor pathway', Molecular Pharmacology, 93 168-177 (2018) [C1]
DOI 10.1124/mol.117.109827
Citations Scopus - 3
Co-authors Jennette Sakoff, Adam Mccluskey
2018 Zhou W, Sipilä P, De Iuliis G, Dun MD, Nixon B, 'Analysis of Epididymal Protein Synthesis and Secretion', Jove-Journal of Visualized Experiments, 138 (2018) [C1]
DOI 10.3791/58308
Citations Scopus - 2Web of Science - 2
Co-authors Matt Dun, Brett Nixon
2018 Houston BJ, Nixon B, King BV, Aitken RJ, De Iuliis GN, 'Probing the Origins of 1,800 MHz Radio Frequency Electromagnetic Radiation Induced Damage in Mouse Immortalized Germ Cells and Spermatozoa in vitro', FRONTIERS IN PUBLIC HEALTH, 6 (2018) [C1]
DOI 10.3389/fpubh.2018.00270
Citations Web of Science - 1
Co-authors John Aitken, Bruce King, Brett Nixon
2018 Walters JLH, De Iuliis G, Nixon B, Bromfield EG, 'Oxidative Stress in the Male Germline: A Review of Novel Strategies to Reduce 4-Hydroxynonenal Production', Antioxidants, 7 (2018) [C1]
DOI 10.3390/antiox7100132
Citations Scopus - 2Web of Science - 2
Co-authors Elizabeth Bromfield, Brett Nixon
2018 Walters JLH, De Iuliis GN, Dun MD, Aitken RJ, McLaughlin EA, Nixon B, Bromfield EG, 'Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress.', Biology of reproduction, 98 784-794 (2018) [C1]
DOI 10.1093/biolre/ioy058
Citations Scopus - 4Web of Science - 2
Co-authors Brett Nixon, Elizabeth Bromfield, John Aitken, Matt Dun, Eileen Mclaughlin
2018 Mihalas BP, Bromfield EG, Sutherland JM, De Iuliis GN, McLaughlin EA, John Aitken R, Nixon B, 'Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity', Journal of Biological Chemistry, 293 18944-18964 (2018) [C1]
DOI 10.1074/jbc.RA118.005751
Citations Scopus - 4Web of Science - 3
Co-authors Eileen Mclaughlin, Elizabeth Bromfield, Jessie Sutherland, Brett Nixon, John Aitken
2018 Houston BJ, Nixon B, Martin JH, De Iuliis GN, Trigg NA, Bromfield EG, et al., 'Heat exposure induces oxidative stress and DNA damage in the male germ line', BIOLOGY OF REPRODUCTION, 98 593-606 (2018) [C1]
DOI 10.1093/biolre/ioy009
Citations Scopus - 10Web of Science - 8
Co-authors John Aitken, Jacinta Martin, Elizabeth Bromfield, Brett Nixon
2017 Zhou W, De Iuliis GN, Turner AP, Reid AT, Anderson AL, McCluskey A, et al., 'Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis', BIOLOGY OF REPRODUCTION, 96 159-173 (2017) [C1]
DOI 10.1095/biolreprod.116.145433
Citations Scopus - 6Web of Science - 5
Co-authors Andrew Reid, Eileen Mclaughlin, Brett Nixon, Adam Mccluskey
2017 Mihalas BP, De Iuliis GN, Redgrove KA, McLaughlin EA, Nixon B, 'The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte', SCIENTIFIC REPORTS, 7 (2017) [C1]
DOI 10.1038/s41598-017-06372-z
Citations Scopus - 16Web of Science - 19
Co-authors Brett Nixon, Eileen Mclaughlin, Kate Redgrove
2017 Zhou W, Anderson AL, Turner AP, De Iuliis GN, McCluskey A, McLaughlin EA, Nixon B, 'Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.', Molecular Human Reproduction, 23 657-673 (2017) [C1]
DOI 10.1093/molehr/gax044
Citations Scopus - 3Web of Science - 3
Co-authors Eileen Mclaughlin, Brett Nixon, Adam Mccluskey
2016 Houston B, Nixon B, King BV, De Iuliis GN, Aitken RJ, 'The effects of radiofrequency electromagnetic radiation on sperm function', Reproduction, 152 R263-R276 (2016) [C1]
DOI 10.1530/REP-16-0126
Citations Scopus - 15Web of Science - 14
Co-authors Brett Nixon, John Aitken, Bruce King
2016 Aitken RJ, Muscio L, Whiting S, Connaughton HS, Fraser BA, Nixon B, et al., 'Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology', Biochemical Pharmacology, 121 78-96 (2016) [C1]
DOI 10.1016/j.bcp.2016.09.015
Citations Scopus - 8Web of Science - 7
Co-authors John Aitken, Brett Nixon
2014 Aitken RJ, Finnie JM, Muscio L, Whiting S, Connaughton HS, Kuczera L, et al., 'Potential importance of transition metals in the induction of DNA damage by sperm preparation media', Human Reproduction, 29 2136-2147 (2014) [C1]

© The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. STUDY QUESTION: What are the m... [more]

© The Author 2014. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. STUDY QUESTION: What are the mechanisms by which the preparation of spermatozoa on discontinuous density gradients leads to an increase in oxidative DNA damage? SUMMARY ANSWER: The colloidal silicon solutions that are commonly used to prepare human spermatozoa for assisted reproduction technology (ART) purposes contain metals in concentrations that promote free radical-mediated DNA damage. WHAT IS KNOWN ALREADY: Sporadic reports have already appeared indicating that the use of colloidal silicon-based discontinuous density gradients for sperm preparation is occasionally associated with the induction of oxidative DNA damage. The cause of this damage is however unknown. STUDY DESIGN, SIZE, DURATION: This study comprised a series of experiments designed to: (i) confirm the induction of oxidativeDNA damage in spermatozoa prepared on commercially available colloidal silicon gradients, (ii) compare the levels of damage observed with alterative sperm preparation techniques including an electrophoretic approach and (iii) determine the cause of the oxidative DNA damage and develop strategies for its prevention. The semen samples employed for this analysis involved a cohort of >50 unselected donors and at least three independent samples were used for each component of the analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS: The setting was a University biomedical science laboratory. The major techniques employed were: (i) flow cytometry to study reactive oxygen species generation, lipid peroxidation and DNA damage, (ii) computeraided sperm analysis to measure spermmovement and (iii) inductively coupled mass spectrometry to determine the elemental composition of sperm preparation media. MAIN RESULTS AND THE ROLE OF CHANCE: Oxidative DNA damage is induced in spermatozoa prepared on PureSperm® discontinuous colloidal silicon gradients (P < 0.001 versus repeated centrifugation) because this medium contains metals, particularly Fe, Al and Cu, which are known to promote free radical generation in the immediate vicinity of DNA. This damage can be significantly accentuated by reducing agents, such as ascorbate (P < 0.001) and inhibited by selective chelation (P < 0.001). This problem is not confined to PureSperm®; analysis of additional commercial sperm preparation media revealed that metal contamination is a relatively constant feature of such products. LIMITATIONS, REASONS FOR CAUTION: While the presence of metals, particularly transition metals, may exacerbate the levels of oxidative DNA damage seen in human spermatozoa, the significance of such damage has not yet been tested in suitably powered clinical trials. WIDER IMPLICATIONS OF THE FINDINGS: The results explain why the preparation of spermatozoa on discontinuous colloidal silicon gradients can result in oxidative DNA damage. The results are of immediate relevance to the development of safe, effective protocols for the preparation of spermatozoa for ART purposes. STUDY FUNDING/COMPETING INTEREST(S): The studywas funded by the Australian Health and Medical ResearchCouncil. One of the authors (R.J.A.) has had a consultantship with a biotechnology company, NuSep, interested in the development of electrophoretic methods of sperm preparation. He has no current financial interest in this area. None of the other authors have a conflict of interest to declare.

DOI 10.1093/humrep/deu204
Citations Scopus - 35Web of Science - 30
Co-authors John Aitken, Tony Rothkirch
2014 Aitken RJ, Smith TB, Jobling MS, Baker MA, De Iuliis GN, 'Oxidative stress and male reproductive health', Asian Journal of Andrology, 16 31-38 (2014) [C1]

One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cell... [more]

One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to proteins and lipids in the sperm plasma membrane. The origins of such oxidative stress appear to involve the sperm mitochondria, which have a tendency to generate high levels of superoxide anion as a prelude to entering the intrinsic apoptotic cascade. Unfortunately, these cells have very little capacity to respond to such an attack because they only possess the first enzyme in the base excision repair (BER) pathway, 8-oxoguanine glycosylase 1 (OGG1). The latter successfully creates an abasic site, but the spermatozoa cannot process the oxidative lesion further because they lack the downstream proteins (APE1, XRCC1) needed to complete the repair process. It is the responsibility of the oocyte to continue the BER pathway prior to initiation of S-phase of the first mitotic division. If a mistake is made by the oocyte at this stage of development, a mutation will be created that will be represented in every cell in the body. Such mechanisms may explain the increase in childhood cancers and other diseases observed in the offspring of males who have suffered oxidative stress in their germ line as a consequence of age, environmental or lifestyle factors. The high prevalence of oxidative DNA damage in the spermatozoa of male infertility patients may have implications for the health of children conceivedin vitro and serves as a driver for current research into the origins of free radical generation in the germ line. © 2014 AJA, SIMM & SJTU. All rights reserved.

DOI 10.4103/1008-682X.122203
Citations Scopus - 192Web of Science - 166
Co-authors Mark Baker, John Aitken
2013 De Iuliis GN, Newey RJ, King BV, Aitken RJ, 'Correction: Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro (PLoS ONE)', PLoS ONE, 8 (2013)
DOI 10.1371/annotation/9a8a0172-3850-4059-b852-72c330769c1b
Citations Scopus - 1
Co-authors Bruce King, John Aitken
2013 Aitken RJ, Bronson R, Smith TB, De Iuliis GN, 'The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies', Molecular Human Reproduction, 19 475-485 (2013) [C1]
DOI 10.1093/molehr/gat025
Citations Scopus - 79Web of Science - 63
Co-authors John Aitken
2013 Smith TB, De Iuliis GN, Lord T, Aitken RJ, 'The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line', Reproduction, 146 253-262 (2013) [C1]
DOI 10.1530/REP-13-0186
Citations Scopus - 29Web of Science - 23
Co-authors John Aitken, Tessa Lord
2013 Lewis SEM, Aitken RJ, Conner SJ, De Iuliis G, Evenson DP, Henkel R, et al., 'The impact of sperm DNA damage in assisted conception and beyond: Recent advances in diagnosis and treatment', Reproductive BioMedicine Online, 27 325-337 (2013) [C1]
DOI 10.1016/j.rbmo.2013.06.014
Citations Scopus - 111Web of Science - 98
Co-authors John Aitken
2013 Aitken RJ, Smith TB, Lord T, Kuczera L, Koppers AJ, Naumovski N, et al., 'On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid', Andrology, 1 192-205 (2013) [C1]
DOI 10.1111/j.2047-2927.2012.00056.x
Citations Scopus - 42Web of Science - 38
Co-authors John Aitken, Tessa Lord, Mark Baker
2012 Aitken RJ, Gibb Z, Mitchell LA, Lambourne SR, Connaughton HS, De Iuliis GN, 'Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols', Biology of Reproduction, 87 1-11 (2012) [C1]
Citations Scopus - 94Web of Science - 87
Co-authors John Aitken, Zamira Gibb
2012 Aitken RJ, Whiting SJ, De Iuliis GN, McClymont SL, Mitchell LA, Baker MA, 'Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase', Journal of Biological Chemistry, 287 33048-33060 (2012) [C1]
DOI 10.1074/jbc.M112.366690
Citations Scopus - 96Web of Science - 93
Co-authors Mark Baker, John Aitken
2012 Aitken RJ, De Iuliis GN, Gibb Z, Baker MA, 'The Simmet lecture: New horizons on an old landscape - oxidative stress, DNA damage and apoptosis in the male germ line', Reproduction in Domestic Animals, 47 7-14 (2012) [C2]
Citations Scopus - 32Web of Science - 30
Co-authors John Aitken, Mark Baker, Zamira Gibb
2011 Aitken RJ, Mitchell L, De Iuliis GN, 'Reply: M540 bodies interfere with TUNEL analyses in human semen samples', HUMAN REPRODUCTION, 26 729-730 (2011) [C3]
DOI 10.1093/humrep/deq371
Citations Scopus - 1
Co-authors John Aitken
2010 Aitken RJ, De Iuliis GN, Finnie JM, Hedges A, McLachlan RI, 'Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: Development of diagnostic criteria', Human Reproduction, 25 2415-2426 (2010) [C1]
DOI 10.1093/humrep/deq214
Citations Scopus - 198Web of Science - 178
Co-authors John Aitken
2010 Mitchell LA, De Iuliis GN, Aitken RJ, 'The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: Development of an improved methodology', International Journal of Andrology, 34 2-13 (2010) [C1]
DOI 10.1111/j.1365-2605.2009.01042.x
Citations Scopus - 92Web of Science - 95
Co-authors John Aitken
2010 Aitken RJ, De Iuliis GN, 'On the possible origins of DNA damage in human spermatozoa', Molecular Human Reproduction, 16 3-13 (2010) [C1]
DOI 10.1093/molehr/gap059
Citations Scopus - 291Web of Science - 271
Co-authors John Aitken
2009 De Iuliis GN, Newey RJ, King BV, Aitken RJ, 'Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro', PLoS ONE, 4 e6446 (2009) [C1]
DOI 10.1371/journal.pone.0006446
Citations Scopus - 247Web of Science - 185
Co-authors Bruce King, John Aitken
2009 Bennetts LE, De Iuliis GN, Nixon B, Kime M, Zelski K, McVicar CM, et al., 'Impact of Estrogenic Compounds on DNA Integrity in Human Spermatozoa: Evidence for Cross-Linking and Redox Cycling Activities', JOURNAL OF UROLOGY, 181 914-915 (2009) [C1]
Citations Scopus - 70Web of Science - 68
Co-authors John Aitken, Brett Nixon
2009 De Iuliis GN, Thomson LK, Mitchell LA, Read JM, Koppers AJ, Hedges A, et al., 'DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress', Biology of Reproduction, 81 517-524 (2009) [C1]
DOI 10.1095/biolreprod.109.076836
Citations Scopus - 209Web of Science - 204
Co-authors John Aitken, Brett Nixon
2009 Czarny NA, Harris MS, De Iuliis GN, Rodger JC, 'Acrosomal integrity, viability, and DNA damage of sperm from dasyurid marsupials after freezing or freeze drying', Theriogenology, 72 817-825 (2009) [C1]
DOI 10.1016/j.theriogenology.2009.05.018
Citations Scopus - 14Web of Science - 12
Co-authors Merrilee Harris, John Rodger
2009 Aitken RJ, De Iuliis GN, McLachlan RI, 'Biological and clinical significance of DNA damage in the male germ line', International Journal of Andrology, 32 46-56 (2009) [C1]
DOI 10.1111/j.1365-2605.2008.00943.x
Citations Scopus - 231Web of Science - 201
Co-authors John Aitken
2009 Thomson LK, Fleming SD, Aitken RJ, De Iuliis GN, Zieschang JA, Clark AM, 'Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis', Human Reproduction, 24 2061-2070 (2009) [C1]
DOI 10.1093/humrep/dep214
Citations Scopus - 208Web of Science - 197
Co-authors John Aitken
2008 Koppers AJ, De Iuliis GN, Read JM, McLaughlin EA, Aitken RJ, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
DOI 10.1210/jc.2007-2616
Citations Scopus - 311Web of Science - 296
Co-authors Eileen Mclaughlin, John Aitken
2007 Aitken RJ, Wingate JK, De Iuliis GN, McLaughlin EA, 'Analysis of lipid peroxidation in human spermatozoa using BODIPY C11', Molecular Human Reproduction, 13 203-211 (2007) [C1]
DOI 10.1093/molehr/gal119
Citations Scopus - 102Web of Science - 100
Co-authors Eileen Mclaughlin, John Aitken
2007 Aitken RJ, De Iuliis GN, 'Value of DNA integrity assays for fertility evaluation', Society for Reproduction and Fertility Supplement, 65 81-92 (2007) [C1]
Citations Scopus - 66
Co-authors John Aitken
2007 Aitken RJ, De Iuliis GN, 'Origins and consequences of DNA damage in male germ cells', Reproductive Biomedicine Online, 14 727-733 (2007) [C1]
DOI 10.1016/S1472-6483(10)60676-1
Citations Scopus - 249Web of Science - 238
Co-authors John Aitken
2006 De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
DOI 10.1210/jc.2005-2711
Citations Scopus - 95Web of Science - 84
Co-authors John Aitken, Eileen Mclaughlin
2006 Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA, 'Cis-unsaturated Fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 4154-4163 (2006) [C1]
DOI 10.1210/jc.2006-1309
Citations Scopus - 109Web of Science - 105
Co-authors John Aitken, Eileen Mclaughlin
2006 McCann N, De Iuliis GN, Lawrance GA, Maeder M, Schrader K, Moore P, 'Mono- and dinuclear copper(II) complexes of pendant-arm macrocyclic polyamines: Synthesis, characterization and investigation as hydrolytic cleavage agents for DNA', Inorganic Reaction Mechanisms, 6 91-112 (2006) [C1]
DOI 10.1515/IRM.2006.6.2.91
Citations Scopus - 3Web of Science - 3
Co-authors Marcel Maeder, Geoffrey Lawrance
2004 Robertson MJ, De Iuliis GN, Maeder M, Lawrance GA, 'Metal-directed synthesis of a chiral acyclic pentaamine and pendant-arm macrocyclic hexaamine derived from an amino acid', Inorganica Chimica Acta, 357 557-570 (2004) [C1]
DOI 10.1016/j.ica.2003.08.018
Citations Scopus - 13Web of Science - 13
Co-authors Geoffrey Lawrance, Marcel Maeder
2003 Comba P, De Iuliis GN, Lawrance GA, Luther S, Maeder M, Nolan AL, et al., 'Geometrical isomerism in octahedral complexes arising from the presence of a fused ring on a triaza macrocycle', Dalton Transactions, 2188-2193 (2003) [C1]
DOI 10.1039/b303515h
Citations Scopus - 7Web of Science - 6
Co-authors Marcel Maeder, Geoffrey Lawrance
2003 De Iuliis GN, Lawrance GA, Bernhardt PV, 'DNA cleavage with dinuclear metal complexes of ligands with varying flexibility', Journal of Inorganic Biochemistry, 96 158 (2003) [C3]
Co-authors Geoffrey Lawrance
2002 De Iuliis GN, Lawrance GA, Wilson N, 'Metal complex-promoted cleavage of RNA dimers and trimers; electrospray ionisation mass spectrometry evidence for cleavage', Inorganic Reaction Mechanisms, 4 169-186 (2002) [C1]
Citations Web of Science - 1
Co-authors Geoffrey Lawrance
2000 De Iuliis GN, Lawrance GA, Fieuw-Makaroff S, 'Superior hydrolytic DNA cleavage by a dinuclear copper(II) N4S4-donor complex compared with a mononuclear N2S2-donor close analogue', INORGANIC CHEMISTRY COMMUNICATIONS, 3 307-309 (2000) [C1]
Citations Scopus - 37Web of Science - 31
Co-authors Geoffrey Lawrance
Show 45 more journal articles

Conference (16 outputs)

Year Citation Altmetrics Link
2018 De Iuliis GN, Milhalas BP, Redgrove KA, McLaughlin EA, Nixon B, 'Mechanisms responsible for the age-related decline in oocyte quality: the use of antioxidants to halt the aging process in eggs', Hunter Valley, NSW (2018)
Co-authors Eileen Mclaughlin, Kate Redgrove, Brett Nixon
2017 De Iuliis G, Nixon B, Aitken R, 'Causes and consequences of oxidative damage in the male germ line', Copenhagen, Denmark (2017)
Co-authors Brett Nixon, John Aitken
2016 De Iuliis GN, Cui J, Bromfield E, Nixon B, 'Oxidative Stress-Induced Protein Modifications in Spermatozoa and Consequences for Sperm-Oocyte Recognition', Gold Coast, Australia (2016)
Co-authors Brett Nixon
2014 De Iuliis GN, Verrills NM, Dun MD, 'IN SILICO ANALYSIS OF THE TARGETS OF SMALL-MOLECULE, ANTI-CANCER COMPOUNDS FOR IMPROVED CANCER THERAPEUTICS', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Matt Dun, Nikki Verrills
2014 Gilbert J, Dun MD, De Iuliis GN, McCluskey A, Sakoff JA, 'SELECTIVELY TARGETING BREAST CANCER CELLS VIA CHECKPOINT ACTIVATION', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Matt Dun, Jennette Sakoff, Adam Mccluskey
2009 Aitken RJ, De Iuliis GN, Koppers AJ, 'OXIDATIVE STRESS AND SPERMATOZOA HEALTH', JOURNAL OF ANDROLOGY, Barcelona, SPAIN (2009) [E3]
Co-authors John Aitken
2009 de Iuliis GN, Newey RJ, King BV, Aitken RJ, 'MOBILE PHONE RADIATION INDUCES REACTIVE OXYGEN SPECIES PRODUCTION AND DNA DAMAGE IN HUMAN SPERMATOZOA IN VITRO', JOURNAL OF ANDROLOGY, Barcelona, SPAIN (2009) [E3]
Co-authors John Aitken, Bruce King
2008 De Iuliis GN, Nixon K, Aitken RJ, 'Estrogenic compounds induce oxidative stress in human spermatozoa: Implications for DNA integrity and fertilization success', Biology of Reproduction, Kailua-Kona, Hawaii (2008) [E3]
Co-authors John Aitken
2008 Aitken RJ, De Iuliis GN, Nixon B, Roman SD, 'Causes and clinical significance of DNA damage in the male germ line', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authors Shaun Roman, John Aitken, Brett Nixon
2008 Aitken R, Do Iuliis G, Nixon B, Roman S, 'Causes and clinical significance of DNA damage in the male germ line', BIOLOGY OF REPRODUCTION, Kona, HI (2008) [E3]
Co-authors Brett Nixon, Shaun Roman, John Aitken
2007 Schjenken JE, Stanger SJ, Smith V, Douglas A, De Iuliis GN, Depaz I, et al., 'Expression and activity of phase 1 detoxifying enzymes in the male sperm line of the mouse', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authors Brett Nixon, John Aitken, Shaun Roman
2007 Aitken RJ, De Iuliis GN, 'Midnight's broken toll: The male germ cell and its role in the aetiology of genetic disease', Early Human Development, Perth, W.A. (2007) [E3]
Co-authors John Aitken
2007 De Iuliis GN, Zelski K, Aitken RJ, 'The Impact of Estrogenic Compounds on DNA Integrity in the Male Germ Line', Endocrine Society of Australia (ESA) & Society for Reproductive Biology (SRB) Annual Scientific Meeting. Proceedings, Christchurch, New Zealand (2007) [E3]
Co-authors John Aitken
2006 Aitken RJ, De Iuliis GN, 'Value of DNA integrity assays for fertility evaluation', Abstracts, Madrid, Spain (2006) [E3]
Co-authors John Aitken
2004 De Iuliis GN, MacDougall IJA, Griffith R, 'Molecular modelling of alpha 1b and alpha 1d adrenoceptors and investigations into the effects of water and adrenaline', MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]
2003 De Iuliis GN, Griffith R, 'Molecular Dynamics Studies On A Model Of The a1b-Adrenergic Receptor: The Effects Of Water, Adrenaline And Site Directed Mutagenesis', TOMECS International Symposium AIMECS 03 Post Symposium Meeting Abstracts, Sunforte, Japan (2003) [E3]
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Grants and Funding

Summary

Number of grants 5
Total funding $535,645

Click on a grant title below to expand the full details for that specific grant.


20192 grants / $486,645

Utilising the male germline to define our understanding of the biological effects of radio frequency electromagnetic energy$431,775

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Geoffry De Iuliis, Dr King Yuk Chan, chan, King Yuk, Professor Brett Nixon, Professor Rodica Ramer, Ramer, Rodica
Scheme Project Grant
Role Lead
Funding Start 2019
Funding Finish 2021
GNo G1800050
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

IVOS II-Animal-basic for computer assisted analysis of sperm from multiple species$54,870

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Mark Baker, Doctor Zamira Gibb, Doctor Aleona Swegen, Doctor Geoffry De Iuliis, Doctor Benjamin Curry
Scheme Equipment Grant
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1900305
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

20171 grants / $20,000

The quantitative analysis of the oxidative stress biomarker 8-OHG in infertile men$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Geoffry De Iuliis
Scheme Project Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1700989
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

20131 grants / $14,000

NucleoCounter SP100$14,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling, Doctor Zamira Gibb, Mr Nenad Naumovski
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201175
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20121 grants / $15,000

BMG SPECTROstar Nano$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Associate Professor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100971
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y
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Research Supervision

Number of supervisions

Completed3
Current5

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2019 PhD The Development of Novel Materials for the Selection of High Quality Spermatozoa and the Assessment of Cellular Oxidative Status Through the Analysis of Lipid Peroxide Metabolites PhD (Biological Sciences), Faculty of Science, The University of Newcastle Principal Supervisor
2019 Masters Heat Shock Protein A2 (HSPA2): Regulatory Roles in Germ Cell Development and Sperm Function M Philosophy (Biological Sc), Faculty of Science, The University of Newcastle Principal Supervisor
2018 PhD Targeting Oxidative Stress for the Improved Treatment of Acute Myeloid Leukaemia PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Epididymosomes and Environmental Epigenetic Inheritance PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
2017 PhD Regulation of Sperm Function and Oxidative Stress by Lipoxygenase Enzymes PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2019 PhD Functional Characterisation of Dynamin in Spermatozoa Epididymal Maturation and Acrosomal Exocytosis PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
2018 PhD Investigating the Effects of Mobile Phone Radiation and Heating on Spermatogenesis and Sperm Function PhD (Biological Sciences), Faculty of Science, The University of Newcastle Co-Supervisor
2016 Masters Oxidative Stress, Sperm DNA Fragmentation and Outcome of Assisted Reproduction Medical Science, University of Western Sydney Co-Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 59
New Zealand 6
United Kingdom 3
United States 2
Germany 1
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News

New hope to stop the female biological clock

July 25, 2017

UON researchers have identifyied an antioxidant which has demonstrated potential to halt the aging process in female eggs.

Dr Geoffry De Iuliis

Position

Senior Lecturer
School of Environmental and Life Sciences
Faculty of Science

Focus area

Reproductive Medicine

Contact Details

Email geoffry.deiuliis@newcastle.edu.au
Phone (02) 4921 7295
Fax (02) 4921 6308
Link Research Networks

Office

Room LS4-47
Building Life Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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