Dr Kira Groen

Dr Kira Groen

Research Associate

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Dr Kira Groen was recently awarded her PhD (September 2020) and now works with Dr Kelly Avery-Kiejda on the role p53 isoforms (which regulate the canonical function of p53) in breast cancer and melanoma. With Dr Avery-Kiejda and her research group, Dr Groen is evaluating the potential p53 isoforms have in serving as biomarkers in melanoma, determining the specific function of delta40p53, a p53 isoform, through knockdown and over-expression models, and investigating the possibility of modulating delta40p53 expression to reduce chemotherapy resistance in oestrogen-positive breast cancer. 

In addition to her research commitment, Dr Groen is actively involved in community engagement. She is a member of the Community Engagement Committee of the Hunter Cancer Research Alliance. Dr Groen is also a member of the Australian Society for Medical Research (ASMR), the Australian Metastasis Research Society (OzMRS), and the International Women in Multiple Sclerosis (iWiMS). Dr Groen also contributes to the research community as a peer-reviewer for Multiple Sclerosis and Related Disorder and Molecular Biology Reports.

During her PhD candidature, Dr Groen looked  at the role of erythrocyte and erythrocyte-derived extracellular vesicle microRNAs in multiple sclerosis. Dr Groen was interested in epigenetic mechanisms and the role of extracellular vesicles as intercellular messengers in health and disease. Throughout Dr Groen's Honours and PhD, she has developed and optimised erythrocyte purification protocols, RNA extraction from erythrocytes, library preparation and next-generation sequencing techniques. Dr Groen also developed a flow cytometry protocol to quantify extracellular vesicles in plasma. Further, Dr Groen has experience in RNA and DNA extractions, RT-qPCR, blood processing, and cell culture.


Qualifications

  • Doctor of Philosophy in Medicine, University of Newcastle
  • Bachelor of Biomedical Sciences, Bond University
  • Bachelor of Health Science (Honours), Bond University

Keywords

  • delta40p53
  • erythrocytes
  • extracellular vesicles
  • microRNA
  • multiple sclerosis
  • next-generation sequencing

Languages

  • English (Fluent)
  • Portuguese (Fluent)
  • German (Mother)
  • French (Working)

Professional Experience

UON Appointment

Title Organisation / Department

Professional appointment

Dates Title Organisation / Department
15/1/2017 - 31/12/2017 Laboratory Technician

School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Australia

Teaching appointment

Dates Title Organisation / Department
15/1/2015 - 31/12/2015 Semester Tutor

Problem-based learning facilitator for Microbiology and Immunology
Preparing of course material, running of tutorials, marking of oral participation and student engagement
Laboratory demonstrator for Microbiology, Immunology, Human Organ Systems 1, Cell Biology, Principles of Human Structure, and Function, and Year 1 Medicine

Bond University
Faculty of Health Sciences and Medicine
Australia

Awards

Award

Year Award
2018 Best Student Oral Presentation at the Australasian Extracellular Vesicle Meeting
International Society for Extracellular Vesicles
2014 First in Class Award BMED12-125 “Medical Biochemistry and Molecular Design”
Bond University
2014 First in Class Award HPER12-101 “Health Research Methods”
Bond University
2014 First in Class Award CORE11-101 “Public Speaking: Presentation Skills for Leaders”
Bond University
2014 First in Class Award BMED12-18 “Laboratory Medicine"
Bond University
2014 First in Class Award HPER11-102 “Health Promotion”
Bond University
2014 First in Class Award BMED12-120 “Pathophysiology and Pharmacology”
Bond University
2014 First in Class Award HPER12-103 “Health Communication”
Bond University
2013 First in Class Award BMED 12-124 “Human Organ Systems 2”
Bond University
2013 First in Class Award BMED11-110 “Human Organ Systems 1"
Bond University
2013 First in Class Award BMED11- 207 “Medical and Molecular Genetics”
Bond University
2013 First in Class Award BMED11-106 “Microbiology”
Bond University
2013 First in Class Award BMED11-204 “Chemistry"
Bond University
2013 First in Class Award BMED11-203 “Cell Biology”
Bond University

Distinction

Year Award
2016 Vice Chancellor’s List of Academic Excellence
Bond University
2015 Valedictorian of the Faculty of Health Science and Medicine
Bond University
2014 Vice-Chancellor’s List of Academic Excellence
Bond University
2013 Vice-Chancellor’s List of Academic Excellence
Bond University

Nomination

Year Award
2015 Nomination for Pearson Student of the Year
Pearson Australia

Recognition

Year Award
2017 Three Minute Thesis Pre-Confirmation Finalist
The University of Newcastle

Scholarship

Year Award
2015 Dean’s Scholarship Bond University
Bond University
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (7 outputs)

Year Citation Altmetrics Link
2020 Maltby VE, Lea RA, Burnard S, Xavier A, Van Cao T, White N, et al., 'Epigenetic differences at the HTR2A locus in progressive multiple sclerosis patients.', Sci Rep, 10 22217 (2020)
DOI 10.1038/s41598-020-78809-x
Co-authors Rodney Scott, Vicki E Maltby, Jeannette Lechner-Scott
2020 Steffens Reinhardt L, Zhang X, Wawruszak A, Groen K, De Iuliis GN, Avery-Kiejda KA, 'Good Cop, Bad Cop: Defining the Roles of 40p53 in Cancer and Aging', Cancers, 12 (2020) [C1]
DOI 10.3390/cancers12061659
Citations Scopus - 1Web of Science - 1
Co-authors Geoffry DeiuliIs, Kelly Kiejda
2020 Groen K, Maltby VE, Scott RJ, Tajouri L, Lechner-Scott J, 'Erythrocyte microRNAs show biomarker potential and implicate multiple sclerosis susceptibility genes.', Clinical and translational medicine, 10 74-90 (2020) [C1]
DOI 10.1002/ctm2.22
Co-authors Jeannette Lechner-Scott, Vicki E Maltby, Rodney Scott
2020 Groen K, Maltby VE, Scott RJ, Tajouri L, Lechner-Scott J, 'Concentrations of plasma-borne extracellular particles differ between multiple sclerosis disease courses and compared to healthy controls', Multiple Sclerosis and Related Disorders, 45 (2020) [C1]
DOI 10.1016/j.msard.2020.102446
Co-authors Vicki E Maltby, Jeannette Lechner-Scott, Rodney Scott
2018 Groen K, Lea RA, Maltby VE, Scott RJ, Lechner-Scott J, 'Letter to the editor: blood processing and sample storage have negligible effects on methylation', CLINICAL EPIGENETICS, 10 (2018) [C1]
DOI 10.1186/s13148-018-0455-6
Citations Scopus - 6Web of Science - 6
Co-authors Vicki E Maltby, Rodney Scott, Jeannette Lechner-Scott
2018 Groen K, Maltby VE, Lea RA, Sanders KA, Fink JL, Scott RJ, et al., 'Erythrocyte microRNA sequencing reveals differential expression in relapsing-remitting multiple sclerosis.', BMC medical genomics, 11 (2018) [C1]
DOI 10.1186/s12920-018-0365-7
Citations Scopus - 5Web of Science - 6
Co-authors Vicki E Maltby, Rodney Scott, Jeannette Lechner-Scott
2016 Groen K, Maltby VE, Sanders KA, Scott RJ, Tajouri L, Lechner-Scott J, 'Erythrocytes in multiple sclerosis - forgotten contributors to the pathophysiology?', Multiple Sclerosis Journal Experimental, Translational and Clinical, 2 2055217316649981-2055217316649981 (2016) [C1]
DOI 10.1177/2055217316649981
Co-authors Vicki E Maltby, Rodney Scott, Jeannette Lechner-Scott
Show 4 more journal articles

Conference (7 outputs)

Year Citation Altmetrics Link
2020 Yusof KM, Mahmud R, Abdullah M, Groen K, Avery-Kiejda KA, Rosli R, 'Identification of modifiable and molecular factors associated with breast cancer-related lymphedema in Malaysian breast cancer survivors', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2020)
Co-authors Kelly Kiejda
2019 Maltby VE, Lea RA, Groen K, Burnard S, Sanders K, Seeto R, et al., 'Genome-wide DNA Methylation in Secondary Progressive Multiple Sclerosis Patients Reveals Unique Epigenetic Signature.', MULTIPLE SCLEROSIS JOURNAL, Sydney, AUSTRALIA (2019)
Co-authors Jeannette Lechner-Scott, Vicki E Maltby, Rodney Scott
2019 Groen K, Burnard S, Maltby VE, Scott RJ, Tajouri L, Lechner-Scott J, 'Increased plasma-borne extracellular vesicles in Multiple Sclerosis - Where did they come from?', MULTIPLE SCLEROSIS JOURNAL, Sydney, AUSTRALIA (2019)
Co-authors Vicki E Maltby, Jeannette Lechner-Scott, Rodney Scott
2019 Groen K, Maltby VE, Scott RJ, Tajouri L, Lechner-Scott J, 'Increased erythrocyte microRNA-183 cluster expression during relapse - A potential new MS-specific marker for disease activity?', MULTIPLE SCLEROSIS JOURNAL, Stockholm, SWEDEN (2019)
Co-authors Egbert Groen, Jeannette Lechner-Scott, Rodney Scott, Vicki E Maltby
2018 Maltby V, Lea R, Groen K, Burnard S, Sanders K, Seto R, et al., 'Genome-wide DNA methylation in secondary progressive multiple sclerosis patients reveals unique epigenetic signature', MULTIPLE SCLEROSIS JOURNAL, Berlin, GERMANY (2018)
Co-authors Rodney Scott, Jeannette Lechner-Scott
2018 Groen K, Burnard S, Maltby V, Scott R, Tajouri L, Lechner-Scott J, 'Plasma-borne exctracellular vesicles in multiple sclerosis where did they come from?', MULTIPLE SCLEROSIS JOURNAL, Berlin, GERMANY (2018)
Co-authors Vicki E Maltby, Jeannette Lechner-Scott, Rodney Scott
2017 Groen K, Maltby VE, Tajouri L, Lea RA, Fink L, Sanders KA, et al., 'Altered erythrocyte MicroRNA profiles in relapsing-remitting multiple sclerosis', MULTIPLE SCLEROSIS JOURNAL, Paris, FRANCE (2017)
Co-authors Vicki E Maltby, Rodney Scott, Jeannette Lechner-Scott
Show 4 more conferences
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Grants and Funding

Summary

Number of grants 2
Total funding $30,000

Click on a grant title below to expand the full details for that specific grant.


20191 grants / $5,000

Centre for Brain and Mental Health Infrastructure Grant Round$5,000

Funding for MinION Sequencer

Funding body: Centre for Brain and Mental Health Research

Funding body Centre for Brain and Mental Health Research
Project Team

K. Groen

Scheme Equipment Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo
Type Of Funding Internal
Category INTE
UON N

20181 grants / $25,000

Red blood cell-derived extracellular vesicle microRNAs in Multiple Sclerosis - A form of intercellular communication$25,000

Funding body: Multiple Sclerosis Research Australia Limited (MSRA)

Funding body Multiple Sclerosis Research Australia Limited (MSRA)
Project Team Conjoint Professor Jeannette Lechner-Scott, Doctor Vicki Maltby, Doctor Kira Groen, Miss Kira Groen, Dr Lotti Tajouri, Dr Lotti Tajouri
Scheme Incubator Grant
Role Investigator
Funding Start 2018
Funding Finish 2019
GNo G1800511
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y
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Research Supervision

Number of supervisions

Completed0
Current1

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2019 PhD The Link Between Aberrations in the P53 Pathway and Outcome from DNA-Damaging Therapies in Breast Cancer PhD (Medical Genetics), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
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Dr Kira Groen

Position

Research Associate
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Contact Details

Email kira.groen@newcastle.edu.au
Phone (02) 40420304

Office

Room HMRI, Level 3 West
Building Hunter Medical Research Institute Building
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