Staff Directory

Staff Profile

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Career Summary

Qualifications

PhD, University of Newcastle

Research

Research keywords

Breast Cancer
Cancer
Chemotherapy
Drug Development
Dynamin
Glioblastoma
PP2A

Research expertise

Dr Sakoff is an experienced cell biologist and Chief Hospital Scientist in the Department of Medical Oncology at the Calvary Mater Newcastle Hospital. Dr Sakoff is the leader of the Experimental Therapeutics Group. She has made significant contributions to cancer research particularly in the development of small molecules for the treatment of cancer. Areas of expertise includes cell culture, drug screening, cell biology, proteomics, cell cycle analysis, drug combination studies, clinical toxicity.

Languages

English

Fields of Research

Code	Description	Percentage
111200	Oncology And Carcinogenesis	100

Awards

Research Award.

2000	Young medical researcher of the year Hunter Medical Insitute (Australia) Young medical researcher of the year

Teaching

Teaching keywords

Cancer

Teaching expertise

Selected lectures in drug development.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (49 outputs)

Year	Citation	Altmetrics	Link
2014	Gordon CP, Hizartzidis L, Tarleton M, Sakoff JA, Gilbert J, Campbell BE, et al., 'Discovery of acrylonitrile-based small molecules active against Haemonchus contortus', MEDCHEMCOMM, 5 159-164 (2014) [C1] DOI: 10.1039/c3md00255a \| Author URL Co-authors: ADAM MCCLUSKEY
2014	Al Otaibi A, Gordon CP, Gilbert J, Sakoff JA, McCluskey A, 'The influence of ionic liquids on the Knoevenagel condensation of 1H-pyrrole-2-carbaldehyde with phenyl acetonitriles-cytotoxic 3-substituted-(1H-pyrrol-2-yl)acrylonitriles', RSC Advances, 4 19806-19813 (2014) [C1] DOI: 10.1039/c3ra47418f Co-authors: ADAM MCCLUSKEY
2014	Dyson L, Young KA, McCluskey A, Wright AD, Sakoff JA, 'Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin', Bioorganic and Medicinal Chemistry, 22 1690-1699 (2014) DOI: 10.1016/j.bmc.2014.01.021 Co-authors: ADAM MCCLUSKEY
2013	McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, et al., 'Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis', Traffic, 14 1272-1289 (2013) [C1] DOI: 10.1111/tra.12119 Co-authors: ADAM MCCLUSKEY
2013	Tarleton M, Dyson L, Gilbert J, Sakoff JA, McCluskey A, 'Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents', BIOORGANIC & MEDICINAL CHEMISTRY, 21 333-347 (2013) [C1] DOI: 10.1016/j.bmc.2012.10.003 \| Author URL Co-authors: ADAM MCCLUSKEY
2013	McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, et al., 'Pyrimidyn compounds: Dual-action small molecule pyrimidine-based dynamin inhibitors', ACS Chemical Biology, 8 1507-1518 (2013) [C1] DOI: 10.1021/cb400137p Co-authors: ADAM MCCLUSKEY
2013	Deane FM, O'Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO, 'Synthesis and evaluation of novel ellipticines as potential anti-cancer agents', Organic & Biomolecular Chemistry, 11 1334-1344 (2013) [C1] DOI: 10.1039/c2ob27186a \| Author URL Co-authors: ADAM MCCLUSKEY
2013	McCluskey A, Daniel JA, Hadzic G, Ngoc C, Clayton EL, Mariana A, et al., 'Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis', TRAFFIC, 14 1272-1289 (2013) DOI: 10.1111/tra.12119 \| Author URL Co-authors: ADAM MCCLUSKEY
2012	Garg MB, Lincz L, Adler K, Scorgie FE, Ackland S, Sakoff JA, 'Predicting 5-Fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length - A multivariate analysis', British Journal of Cancer, 107 1525-1533 (2012) [C1] Co-authors: LISA LINCZ, STEPHEN ACKLAND
2012	Tarleton MJ, Gilbert J, Sakoff JA, McCluskey A, 'Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents', European Journal of Medicinal Chemistry, 57 65-73 (2012) [C1] DOI: 10.1016/j.ejmech.2012.09.019 Co-authors: ADAM MCCLUSKEY
2012	Tarleton MJ, Gilbert J, Sakoff JA, McCluskey A, 'Synthesis and anticancer activity of a series of norcantharidin analogues', European Journal of Medicinal Chemistry, 54 573-581 (2012) [C1] Co-authors: ADAM MCCLUSKEY
2011	Campbell BE, Tarleton MJ, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB, 'Norcantharidin analogues with nematocidal activity in Haemonchus contortus', Bioorganic and Medicinal Chemistry Letters, 21 3277-3281 (2011) [C1] DOI: 10.1016/j.bmcl.2011.04.031 Co-authors: ADAM MCCLUSKEY
2011	Tarleton MJ, Gilbert J, Robertson MJ, McCluskey A, Sakoff JA, 'Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound', MedChemComm, 2 31-37 (2011) [C1] DOI: 10.1039/c0md00147c Co-authors: ADAM MCCLUSKEY
2011	Robertson MJ, Gordon CP, Gilbert J, McCluskey A, Sakoff JA, 'Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity', Bioorganic & Medicinal Chemistry, 19 5734-5741 (2011) [C1] DOI: 10.1016/j.bmc.2011.01.031 Co-authors: ADAM MCCLUSKEY
2011	Garg MB, Sakoff JA, Ackland S, 'A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 879 2201-2205 (2011) [C1] Co-authors: STEPHEN ACKLAND
2010	Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, et al., 'The Dynamin inhibitors MiTMAB and OcTMAB induce Cytokinesis failure and inhibit cell proliferation in human cancer cells', Molecular Cancer Therapeutics, 9 1995-2006 (2010) [C1] DOI: 10.1158/1535-7163.mct-10-0161 Co-authors: ADAM MCCLUSKEY
2010	Thaqi A, Scott JL, Gilbert J, Sakoff JA, McCluskey A, 'Synthesis and biological activity of Delta-5,6-norcantharimides: Importance of the 5,6-bridge', European Journal of Medicinal Chemistry, 45 1717-1723 (2010) [C1] DOI: 10.1016/j.ejmech.2010.01.004 Co-authors: ADAM MCCLUSKEY
2010	De Bock CE, Garg ML, Scott NM, Sakoff JA, Scorgie FE, Ackland S, Lincz L, 'Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo', Pharmacogenomics Journal, 1-8 (2010) [C1] DOI: 10.1038/tpj.2010.43 Co-authors: LISA LINCZ, MANOHAR GARG, STEPHEN ACKLAND
2009	Sauer B, Gilbert J, Sakoff JA, McCluskey A, 'Synthesis of 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl Acetic Acid Ethyl Esters as Norcantharidin Analogues', Letters in Drug Design & Discovery, 6 1-7 (2009) [C1] DOI: 10.2174/157018009787158535 Co-authors: ADAM MCCLUSKEY
2009	Holland IP, McCluskey A, Sakoff JA, Gilbert J, Chau N, Robinson PJ, et al., 'Steroids from an Australian Sponge Psammoclema sp', Journal of Natural Products, 72 102-106 (2009) [C1] DOI: 10.1021/np800688f Co-authors: ADAM MCCLUSKEY
2009	Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell L, Chau N, et al., 'Inhibition of dynamin mediated endocytosis by the dynoles-synthesis and functional activity of a family of indoles', Journal of Medicinal Chemistry, 52 3762-3773 (2009) [C1] DOI: 10.1021/jm900036m Co-authors: ADAM MCCLUSKEY
2008	Hill TA, Stewart SG, Gordon CP, Ackland SR, Gilbert J, Sauer B, et al., 'Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition', ChemMedChem, 3 1878-1892 (2008) [C1] DOI: 10.1002/cmdc.200800192 Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
2008	Lincz L, Mudge L-M, Scorgie FE, Sakoff JA, Hamilton C, Seldon MR, 'Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the [beta symbol] deletion variant', Neoplasia, 10 1131-1137 (2008) [C1] DOI: 10.1593/neo.08644 Co-authors: LISA LINCZ
2007	Hill TA, Stewart SG, Ackland S, Gilbert J, Sauer B, Sakoff JA, McCluskey A, 'Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation', Bioorganic and Medicinal Chemistry, 15 6126-6134 (2007) [C1] DOI: 10.1016/j.bmc.2007.06.034 Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
2007	Stewart SG, Hill TA, Gilbert J, Ackland S, Sakoff JA, McCluskey A, 'Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity', Bioorganic and Medicinal Chemistry, 15 7301-7310 (2007) [C1] DOI: 10.1016/j.bmc.2007.08.028 Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
2007	Hill TA, Stewart SG, Sauer B, Gilbert J, Ackland S, Sakoff JA, McCluskey A, 'Heterocyclic substituted cantharidin and norcantharidin analogues-synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity', Bioorganic and Medicinal Chemistry Letters, 17 3392-3397 (2007) [C1] DOI: 10.1016/j.bmcl.2007.03.093 Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
2005	Hill TA, Sakoff JA, Robinson PJ, McCluskey A, 'Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity', Australian Journal of Chemistry, 58 94-103 (2005) [C1] DOI: 10.1071/CH04143 Co-authors: ADAM MCCLUSKEY
2004	Sakoff JA, Howitt IJ, Ackland S, McCluskey A, 'Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition', Cancer Chemotherapy and Pharmacology, 53 225-232 (2004) [C1] DOI: 10.1007/s00280-003-0730-9 Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
2004	Sakoff JA, McCluskey A, 'Protein Phosphatase Inhibition: Structure Based Design. Towards New Therapeutic Agents', Current Pharmaceutical Design, 10 1139-1159 (2004) [C1] DOI: 10.2174/1381612043452686 Co-authors: ADAM MCCLUSKEY
2004	Lincz L, Scorgie F, Sakoff J, Fagan K, Ackland S, Enno A, 'Telomere length predicts neutrophil recovery in absence of G-CSF after autologous peripheral blood stem cell transplantation', Bone Marrow Transplant, 34 439-445 (2004) [C1] DOI: 10.1038/sj.bmt.1704607 Co-authors: LISA LINCZ, STEPHEN ACKLAND
2004	Hart ME, Chamberlin AR, Walkom CC, Sakoff JA, McCluskey A, 'Modified norcantharidins: synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity', Bioorganic & Medicinal Chemistry Letters, 14 1969-1973 (2004) [C1] DOI: 10.1016/j.bmcl.2004.01.093 Co-authors: ADAM MCCLUSKEY
2003	Ackland S, Bowyer MC, Baldwin ML, Garner JA, Walkom CC, Sakoff JA, McCluskey A, 'Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines', Bioorganic Chemistry, 31 68-79 (2003) [C1] DOI: 10.1016/S0045-2068(02)00524-2 Co-authors: ADAM MCCLUSKEY, MICHAEL BOWYER, STEPHEN ACKLAND
2002	McCluskey A, Ackland S, Gardiner E, Walkom CC, Sakoff J, 'The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?', Anti-Cancer Drug Design, 16 291-303 (2002) [C1] Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
2002	Sakoff J, Ackland S, Baldwin ML, Atherton MA, McCluskey A, 'Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues', Investigational New Drugs, 20 1-11 (2002) [C1] Co-authors: ADAM MCCLUSKEY, MIRELLA ATHERTON, STEPHEN ACKLAND
2002	McCluskey A, Sim A, Sakoff J, 'Serine-threonine protein phosphatase inhibitors: Development of potential therapeutic strategies', Journal of Medicinal Chemistry, 45 1151-1175 (2002) [C1] Co-authors: ADAM MCCLUSKEY, ALISTAIR SIM
2002	McCluskey A, Atherton MA, Walkom CC, Bowyer M, Sim A, Young D, Sakoff J, 'The first two cantharidin analogues displaying PP1 selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1] Co-authors: ADAM MCCLUSKEY, ALISTAIR SIM, MICHAEL BOWYER, MIRELLA ATHERTON
2002	Sakoff J, De Waal E, Garg M, Denham J, Scorgie F, Enno A, et al., 'Telomere Length in Haemopoietic Stem Cells can be Determined from that of Mononuclear Blood Cells or Whole Blood', Leukemia and Lymphoma, 43(10) 2017-2020 (2002) [C1] Co-authors: LISA LINCZ, STEPHEN ACKLAND
2002	Garg MB, Sevester JC, Sakoff JA, Ackland SP, 'Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity', JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 774 223-230 (2002) DOI: 10.1016/S1570-0232(02)00239-8 \| Author URL Co-authors: STEPHEN ACKLAND
2001	McCluskey A, Walkom CC, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA, 'Cantharimides: A new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A', Bioorganic & Medicinal Chemistry Letters, 11 2941-2946 (2001) [C1] Co-authors: ADAM MCCLUSKEY, MICHAEL BOWYER, STEPHEN ACKLAND
2001	McCluskey A, Sakoff JA, 'Small molecule inhibitors of serine/threonine protein phosphatases.', Mini reviews in medicinal chemistry, 1 43-55 (2001) Co-authors: ADAM MCCLUSKEY
2000	Bowyer MC, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1] Co-authors: ADAM MCCLUSKEY, ALISTAIR SIM, MICHAEL BOWYER
2000	Sakoff J, Ackland S, 'Thymidylate synthase inhibition induces S-phase arrest, biphasic mitochondrial alterations and caspase-dependent apoptosis in leukaemia cells', Cancer Chemotherapy and Pharmacology, 46 477-487 (2000) [C1] Co-authors: STEPHEN ACKLAND
2000	McCluskey A, Atherton MA, Mudgee L, Sim A, Sakoff JA, Quinn R, 'Anhydride modified cantharidin analogues. Is ring opening important in the inhibition of protein phosphatase 2A?', European Journal of Medicinal Chemistry, 35 957-964 (2000) [C1] Co-authors: ADAM MCCLUSKEY, ALISTAIR SIM, MIRELLA ATHERTON
2000	Sakoff JA, McCluskey A, Sims ATR, Stewart JF, Ackland SP, 'A counter intuitive therapy for the treatment of cancer: Inhibition of protein phosphatases 1 and 2A by cantharidin (Spanish Fly) analogues.', CLINICAL CANCER RESEARCH, 6 4495S-4495S (2000) Author URL Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
1996	Sakoff J, Dunstan RH, Murdoch RN, 'Uterine lipid alterations during early pseudopregnancy and following the artificial induction of decidualization by Concanavalin A in QS mice', Molecular reproductive Development, 44 93-102 (1996) [C1] Co-authors: HUGH DUNSTAN
1996	Sakoff J, Murdoch RN, 'The role of calcium ions in the Concanavalin A induced decidual cell reaction in pseudopregnant mice', Biochemical and Molecular Medicine, 57 81-90 (1996) [C1]
1996	Sakoff JA, Murdoch RN, 'The role of calcium in the artificially induced decidual cell reaction in pseudopregnant mice', BIOCHEMICAL AND MOLECULAR MEDICINE, 57 81-90 (1996) DOI: 10.1006/bmme.1996.0013 \| Author URL
1995	Sakoff J, Murdoch RN, 'Uterine receptivity to the artificial deciduogenic agent, Concanavalin A in pseudopregnant', Reproduction, Fertility and Development, 7 1095-1100 (1995) [C1]
1994	Sakoff J, Murdoch RN, 'Alterations in uterine calcium ions during the induction of the decidual cell reaction in pseudopregnant mice', journal of reproduction and fertility, 101 97-102 (1994) [C1]
Show 46 more

Conference (18 outputs)

Year	Citation	Altmetrics	Link
2014	Prawira A, Garg MB, Sakoff JA, Lincz LF, Adler K, Scorgie FE, Ackland SP, 'FACTORS PREDICTING RESPONSE AND SURVIVAL IN COLORECTAL CANCER PATIENTS RECEIVING ADJUVANT 5-FLUOROURACIL CHEMOTHERAPY: 10-YEAR FOLLOW-UP OF A PROSPECTIVE PATIENT COHORT', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3] Author URL Co-authors: LISA LINCZ, STEPHEN ACKLAND
2014	Garg MB, Sakoff JA, Johnson C, Bonaventura A, Ackland SP, 'CLINICAL STUDY OF MITOTANE PHARMACODYNAMICS IN ADRENOCORTICAL CANCER IN CHILDREN AND ADULTS', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3] Author URL Co-authors: STEPHEN ACKLAND
2014	Gilbert J, McCluskey A, Sakoff JA, 'ENHANCING RADIATION EFFECTS FOR THE TREATMENT OF BRAIN CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3] Author URL Co-authors: ADAM MCCLUSKEY
2014	Gilbert J, Dun MD, De Iuliis GN, McCluskey A, Sakoff JA, 'SELECTIVELY TARGETING BREAST CANCER CELLS VIA CHECKPOINT ACTIVATION', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3] Author URL Co-authors: ADAM MCCLUSKEY, GEOFFRY DEIULIIS, MATT DUN
2013	Sakoff JA, Gilbert J, Tarleton M, Robertson M, McCluskey A, 'New small molecules targeting breast cancer', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013) [E3] Author URL Co-authors: ADAM MCCLUSKEY
2012	Sakoff JA, Garg MB, Lincz L, Adler K, Scorgie FE, Ackland S, 'Predicting chemotherapy-induced toxicity in cancer patients from peripheral blood telomere length', European Journal of Cancer, Barcelona, Spain (2012) [E3] Co-authors: LISA LINCZ, STEPHEN ACKLAND
2010	Sakoff JA, Garg M, Adler K, Scorgie FE, Lincz L, Ackland S, 'Telomere length in peripheral blood mononuclear cells (PBMNC) predicts for leukopenia, neutropenia and mucositis in colorectal cancer patients treated with 5FU', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3] Co-authors: LISA LINCZ, STEPHEN ACKLAND
2010	Sakoff JA, Garg M, Adler K, Scorgie FE, Lincz L, Ackland S, 'Short telomeres in PBMNC predicts for haematological toxicity in colorectal cancer patients treated with 5FU', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3] Co-authors: LISA LINCZ, STEPHEN ACKLAND
2010	Joshi S, Gaddipatti S, Gilbert J, Smith CM, Gordon CP, Sakoff JA, et al., 'Dynamin inhibition: A new therapeutic approach for the treatment of cancer', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3] Co-authors: ADAM MCCLUSKEY
2010	Garg M, Sakoff JA, Ackland S, 'A simple HPLC method to measure plasma mitotane and its two main metabolites in adrenocortical cancer patients', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3] Co-authors: STEPHEN ACKLAND
2010	Chircop M, Perera S, Ma MPC, Lau H, Gilbert J, Jones NC, et al., 'Dynole 34-2 is a potent inhibitor of dynamin that induces cell death following cytokinesis failure and suppresses glioblastoma tumour growth in vivo', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3] Co-authors: ADAM MCCLUSKEY
2002	Sakoff JA, Ackland SP, Garg MB, Walkom CC, McCluskey A, 'Protein phosphatase 2A, a novel and unexplored anticancer target', EUROPEAN JOURNAL OF CANCER, FRANKFURT, GERMANY (2002) Author URL Co-authors: ADAM MCCLUSKEY, STEPHEN ACKLAND
1996	Sakoff JA, Murdoch RN, 'Uterine decidualization and calcium ion alterations in pseudopregnant mice' (1996) [E1]
1995	Sakoff JA, Dunstan RH, Murdoch RN, 'The n-3 and n-6 fatty acid profile of uterine tissue following the Concanavalin A induced decidual cell reaction in mice', Unknown, Unknown (1995) [E1]
1995	Sakoff JA, Dunstan RH, Murdoch RN, 'Alterations in uterine saturated fatty acids and cholesterol accompany induction of decidualization in pseudopregnant mice' (1995) [E1]
1994	Sakoff JA, Murdoch RN, 'The period of uterine receptivity in the pseudopregnant Quackenbush Special mouse as defined by the deciduogenic lectin, Concanavalin A' (1994) [E1]
1993	Sakoff JA, Murdoch RN, Dunstan RH, 'Changes in the poly-unsaturated fatty acid composition of the uterus during induction of the decidual cell reaction in pseudopregnant mice', Changes in the poly-unsaturated fatty acid composition of the uterus during induction of the decidual cell reaction in pseudopregnant mice, Unknown (1993) [E1]
1991	Sakoff J, Murdoch RN, 'Uterine decidualization and calcium ion alterations in pseudopregnant mice' (1991) [E1]
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Grants and Funding

Summary

Number of grants	27
Total funding	$2,607,036

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (2 grants)

Enhancing radiation effects for the treatment of brain cancer $25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Dr JAYNE Gilbert, Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$25,000	2014	2014
GNo:G1301412

An Investigation on the Consensus Between Different Genomic and Transcriptomic Results in Breast Cancer$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Ms Heloisa Milioli, Professor Pablo Moscato, Doctor Jennette Sakoff, Associate Professor Regina Berretta
Scheme		Role
Jennie Thomas Medical Research Travel Grant		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2014	2014
GNo:G1401334

2013 (1 grants)

The integration of bioinformatics, chemoinformatics, and toxicogenomics methods: a new approach for the identification of combination tailored therapies and novel drug targets in breast cancer$210,000
Funding Body: Cancer Institute NSW

Project Team
Professor Pablo Moscato, Doctor Jennette Sakoff, Associate Professor Regina Berretta
Scheme		Role
NSW Premier's Awards for Outstanding Cancer Research: "Big Data, Big Impact" Grant		Investigator
Total Amount	Funding Start	Funding Finish
$210,000	2013	2015
GNo:G1300826

2012 (7 grants)

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW

Project Team
Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Emeritus Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar
Scheme		Role
Infrastructure Grants		Investigator
Total Amount	Funding Start	Funding Finish
$292,300	2012	2014
GNo:G1200798

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Ms Megan Chircop, Professor Adam McCluskey, Professor Phillip Robinson, Doctor Jennette Sakoff
Scheme		Role
Project Grant		Investigator
Total Amount	Funding Start	Funding Finish
$245,100	2012	2014
GNo:G1101106

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
Scheme		Role
Project Grant		Investigator
Total Amount	Funding Start	Funding Finish
$143,394	2012	2012
GNo:G1200555

Identification of a novel target for the treatment of hormone positive breast cancer$30,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Dr JAYNE Gilbert, Professor Adam McCluskey
Scheme		Role
Breast Cancer Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$30,000	2012	2012
GNo:G1200716

Mitotane pharmacodynamics in Adrenocortical Cancer in children and adults $20,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff, Ms MADHU Garg
Scheme		Role
Project Grant		Investigator
Total Amount	Funding Start	Funding Finish
$20,000	2012	2013
GNo:G1200319

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000
Funding Body: NSW Trade & Investment

Project Team
Professor Adam McCluskey, Doctor Jennette Sakoff
Scheme		Role
TechVouchers Program		Investigator
Total Amount	Funding Start	Funding Finish
$15,000	2012	2012
GNo:G1200796

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge
Scheme		Role
Equipment Grant		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2012	2012
GNo:G1100986

2011 (4 grants)

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Phillip Robinson, Professor Terence O'Brien, Ms Megan Chircop, Doctor Jennette Sakoff
Scheme		Role
Development Grants		Investigator
Total Amount	Funding Start	Funding Finish
$544,831	2011	2013
GNo:G1000740

Chemical Biology$444,961
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Doctor Warwick Belcher, Doctor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Conjoint Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills
Scheme		Role
Priority Research Centre		Investigator
Total Amount	Funding Start	Funding Finish
$444,961	2011	2015
GNo:G1100052

Computational prediction and functional clarification of novel drug combination strategies for the treatment of brain tumours$50,000
Funding Body: Maitland Cancer Appeal Committee

Project Team
Professor Pablo Moscato, Mr Dan Johnstone, Associate Professor Regina Berretta, Doctor Luke Mathieson, Professor Manuel Graeber, Doctor Jennette Sakoff
Scheme		Role
Research Project		Investigator
Total Amount	Funding Start	Funding Finish
$50,000	2011	2011
GNo:G1100275

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
Scheme		Role
Equipment Grant		Investigator
Total Amount	Funding Start	Funding Finish
$15,000	2011	2011
GNo:G1100028

2010 (1 grants)

New small molecules for the treatment of neuroblastoma$35,000
Funding Body: Hunter Medical Research Institute

Project Team
Dr JAYNE Gilbert, Doctor Jennette Sakoff, Ms Megan Chircop
Scheme		Role
Paediatric Oncology Project Grant		Investigator
Total Amount	Funding Start	Funding Finish
$35,000	2010	2010
GNo:G0900192

2007 (2 grants)

FACSAria - Fluorescence activated cell sorter$300,000
Funding Body: Cancer Institute NSW

Project Team
Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme		Role
Infrastructure Grants		Investigator
Total Amount	Funding Start	Funding Finish
$300,000	2007	2007
GNo:G0187666

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme		Role
Equipment Grant		Investigator
Total Amount	Funding Start	Funding Finish
$52,000	2007	2007
GNo:G0188207

2006 (1 grants)

Overcoming radiation resistance in malignant melanoma$11,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Lisa Lincz, Doctor Jennette Sakoff
Scheme		Role
Project Grant		Investigator
Total Amount	Funding Start	Funding Finish
$11,000	2006	2007
GNo:G0186528

2003 (1 grants)

High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Assoc. Prof David Young, Doctor Jennette Sakoff
Scheme		Role
Discovery Projects		Investigator
Total Amount	Funding Start	Funding Finish
$50,000	2003	2003
GNo:G0182117

2002 (1 grants)

New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff
Scheme		Role
Project Grant		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2002	2002
GNo:G0181459

2001 (3 grants)

Synergistic interaction between thymidylate synthase and protein phosphatase inhibition in colon cancer cells$10,450
Funding Body: University of Newcastle

Project Team
Doctor Jennette Sakoff
Scheme		Role
Early Career Researcher Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$10,450	2001	2001
GNo:G0181233

Predicting bone marrow regeneration in cancer patients through the use of telomere quantitative (Q)-FISH$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Lisa Lincz, Doctor Jennette Sakoff
Scheme		Role
Lions Club of Stroud		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2001	2001
GNo:G0181502

Pulse Education Prize for 2001$3,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$3,000	2001	2001
GNo:G0181503

2000 (3 grants)

A counter-intuitive anticancer treatment.$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$20,000	2000	2000
GNo:G0180205

Influence of Haematopoetic stem cell telorase activity on bone marrow recovery following myoablative therapy.$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Lisa Lincz, Ms Kerry Fagan, Doctor Jennette Sakoff
Scheme		Role
Research Grant		Investigator
Total Amount	Funding Start	Funding Finish
$20,000	2000	2000
GNo:G0180171

Young Medical Researcher of the Year.$5,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$5,000	2000	2000
GNo:G0180182

1999 (1 grants)

Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Professor Adam McCluskey, Conjoint Professor Stephen Ackland
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$25,000	1999	1999
GNo:G0178390

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Research Supervision

Number of current supervisions	1
Total current UoN PhD EFTSL	0.3

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

Commenced	Proposed Completion	Program	Supervisor Type	Research Title
2013	2016	PhD (Biological Sciences)	Co-Supervisor	Biomarker Discovery in Breast Cancer

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Dr Jennette Sakoff

Work Phone	(02) 4921 1149
Fax	(02) 4968 0384
Email	Jennette.Sakoff@newcastle.edu.au
Position	Conjoint Lecturer Experimental Therapeutics Group School of Environmental and Life Sciences Faculty of Science and Information Technology The University of Newcastle, Australia
Focus Area	Chemistry
Office	Department of Medical Oncology, Calvary Mater Newcastle Hospital
URL:	www.newcastle.edu.au/profile/jennette-sakoff

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Staff Profile

Career Summary

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Research

Research keywords

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Languages

Fields of Research

Awards

Research Award.

Teaching

Teaching keywords

Teaching expertise

Publications

Journal article (49 outputs)

Conference (18 outputs)

Grants and Funding

Summary

2014 (2 grants)

Enhancing radiation effects for the treatment of brain cancer $25,000Funding Body: Hunter Medical Research Institute

An Investigation on the Consensus Between Different Genomic and Transcriptomic Results in Breast Cancer$10,000Funding Body: Hunter Medical Research Institute

2013 (1 grants)

The integration of bioinformatics, chemoinformatics, and toxicogenomics methods: a new approach for the identification of combination tailored therapies and novel drug targets in breast cancer$210,000Funding Body: Cancer Institute NSW

2012 (7 grants)

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300Funding Body: Cancer Institute NSW

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100Funding Body: NHMRC (National Health & Medical Research Council)

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394Funding Body: Hunter Medical Research Institute

Identification of a novel target for the treatment of hormone positive breast cancer$30,000Funding Body: Hunter Medical Research Institute

Mitotane pharmacodynamics in Adrenocortical Cancer in children and adults $20,000Funding Body: Hunter Medical Research Institute

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000Funding Body: NSW Trade & Investment

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000Funding Body: NHMRC (National Health & Medical Research Council)

2011 (4 grants)

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831Funding Body: NHMRC (National Health & Medical Research Council)

Chemical Biology$444,961Funding Body: University of Newcastle

Computational prediction and functional clarification of novel drug combination strategies for the treatment of brain tumours$50,000Funding Body: Maitland Cancer Appeal Committee

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000Funding Body: NHMRC (National Health & Medical Research Council)

2010 (1 grants)

New small molecules for the treatment of neuroblastoma$35,000Funding Body: Hunter Medical Research Institute

2007 (2 grants)

FACSAria - Fluorescence activated cell sorter$300,000Funding Body: Cancer Institute NSW

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000Funding Body: Hunter Medical Research Institute

2006 (1 grants)

Overcoming radiation resistance in malignant melanoma$11,000Funding Body: Hunter Medical Research Institute

2003 (1 grants)

High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000Funding Body: ARC (Australian Research Council)

2002 (1 grants)

New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000Funding Body: University of Newcastle

2001 (3 grants)

Synergistic interaction between thymidylate synthase and protein phosphatase inhibition in colon cancer cells$10,450Funding Body: University of Newcastle

Predicting bone marrow regeneration in cancer patients through the use of telomere quantitative (Q)-FISH$10,000Funding Body: Hunter Medical Research Institute

Pulse Education Prize for 2001$3,000Funding Body: Hunter Medical Research Institute

2000 (3 grants)

A counter-intuitive anticancer treatment.$20,000Funding Body: Hunter Medical Research Institute

Influence of Haematopoetic stem cell telorase activity on bone marrow recovery following myoablative therapy.$20,000Funding Body: Hunter Medical Research Institute

Young Medical Researcher of the Year.$5,000Funding Body: Hunter Medical Research Institute

1999 (1 grants)

Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000Funding Body: Hunter Medical Research Institute

Research Supervision

Current Supervision

Dr Jennette Sakoff

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Information for

University of Newcastle

Enhancing radiation effects for the treatment of brain cancer $25,000
Funding Body: Hunter Medical Research Institute

An Investigation on the Consensus Between Different Genomic and Transcriptomic Results in Breast Cancer$10,000
Funding Body: Hunter Medical Research Institute

The integration of bioinformatics, chemoinformatics, and toxicogenomics methods: a new approach for the identification of combination tailored therapies and novel drug targets in breast cancer$210,000
Funding Body: Cancer Institute NSW

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100
Funding Body: NHMRC (National Health & Medical Research Council)

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute

Identification of a novel target for the treatment of hormone positive breast cancer$30,000
Funding Body: Hunter Medical Research Institute

Mitotane pharmacodynamics in Adrenocortical Cancer in children and adults $20,000
Funding Body: Hunter Medical Research Institute

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000
Funding Body: NSW Trade & Investment

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831
Funding Body: NHMRC (National Health & Medical Research Council)

Chemical Biology$444,961
Funding Body: University of Newcastle

Computational prediction and functional clarification of novel drug combination strategies for the treatment of brain tumours$50,000
Funding Body: Maitland Cancer Appeal Committee

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)

New small molecules for the treatment of neuroblastoma$35,000
Funding Body: Hunter Medical Research Institute

FACSAria - Fluorescence activated cell sorter$300,000
Funding Body: Cancer Institute NSW

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000
Funding Body: Hunter Medical Research Institute

Overcoming radiation resistance in malignant melanoma$11,000
Funding Body: Hunter Medical Research Institute

High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000
Funding Body: ARC (Australian Research Council)

New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000
Funding Body: University of Newcastle

Synergistic interaction between thymidylate synthase and protein phosphatase inhibition in colon cancer cells$10,450
Funding Body: University of Newcastle

Predicting bone marrow regeneration in cancer patients through the use of telomere quantitative (Q)-FISH$10,000
Funding Body: Hunter Medical Research Institute

Pulse Education Prize for 2001$3,000
Funding Body: Hunter Medical Research Institute

A counter-intuitive anticancer treatment.$20,000
Funding Body: Hunter Medical Research Institute

Influence of Haematopoetic stem cell telorase activity on bone marrow recovery following myoablative therapy.$20,000
Funding Body: Hunter Medical Research Institute

Young Medical Researcher of the Year.$5,000
Funding Body: Hunter Medical Research Institute

Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000
Funding Body: Hunter Medical Research Institute