Dr Jennifer Baker

Dr Jennifer Baker

Postdoctoral Reseacher

School of Environmental and Life Sciences (Chemistry)

Career Summary

Biography

Receiving undergraduate qualifications in Science from the University of Newcastle in 2014. Jennifer continued on to an Honours degree in Chemistry, graduating in 2016 with Honours Class I. Undertaking a PhD in Medicinal Chemistry, she completed this under the supervision of Prof. Adam McCluskey and Dr. Jennette Sakoff in 2020.

Beginning work as a post-doctoral researcher immediately upon completing her doctorate, Jennifer's interest lies primarily in the development of small molecules for various anti-cancer targets, particularly with the use of in silico modelling techniques for drug design. Additionally, she has a keen interest in the use of Flow Chemistry methodologies for both the synthesis and scale-up of biologically active small molecules. Jennifer is primarily involved with developing small molecules that target Dynamin, a large GTPase that has been associated with a number of human diseases including cancer: as well as the Arylhydrocarbon Receptor, a nuclear translocator that has been associated with breast cancer.

In addition to Jennifer's research, she has been involved in a number of different teaching roles, including the annual outreach events hosted by the School of Environmental and Life Sciences for high school students, Experiment Fest and ASSETS (co-hosted by CSIRO). She has also been involved in lecture and course-coordination roles for the University of Newcastle's enabling programs.


Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Science with a major in Chemistry, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle

Keywords

  • Drug Design
  • Medicinal Chemistry
  • Molecular Modelling
  • Organic Chemistry

Languages

  • English (Mother)

Fields of Research

Code Description Percentage
030401 Biologically Active Molecules 50
030503 Organic Chemical Synthesis 50

Professional Experience

UON Appointment

Title Organisation / Department
Casual Academic University of Newcastle
School of Environmental and Life Sciences
Australia
Casual Lecturer University of Newcastle
Learning and Teaching
Australia
Casual Lecturer University of Newcastle
Learning and Teaching
Australia
Casual Lecturer University of Newcastle
Centre for English Language and Foundation Studies
Australia
Postdoctoral Reseacher University of Newcastle
School of Environmental and Life Sciences
Australia
Casual Academic University of Newcastle
School of Environmental and Life Sciences
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (2 outputs)

Year Citation Altmetrics Link
2019 Paula S, Baker JR, Zhu X, McCluskey A, 'Binding of chlorinated phenylacrylonitriles to the aryl hydrocarbon receptor: computational docking and molecular dynamics simulations', Molecular Docking and Molecular Dynamics, Intech Open, Rijeka 7-18 (2019) [B1]
DOI 10.5772/intechopen.84818
Co-authors Adam Mccluskey
2017 Russell C, Cossar P, Baker J, McCluskey A, 'Recent Developments in the Use of Flow Hydrogenation in the Field of Medicinal Chemistry', New Advances in Hydrogenation Processes - Fundamentals and Applications, InTech, London (2017)
DOI 10.5772/65518
Co-authors Adam Mccluskey, Cecilia Russell

Journal article (9 outputs)

Year Citation Altmetrics Link
2020 Baker JR, Russell CC, Gilbert J, Sakoff JA, McCluskey A, 'Amino Alcohol Acrylonitriles as Activators of the Aryl Hydrocarbon Receptor Pathway: An Unexpected MTT Phenotypic Screening Outcome', ChemMedChem, 15 490-505 (2020) [C1]
DOI 10.1002/cmdc.201900643
Co-authors Cecilia Russell, Jennette Sakoff, Adam Mccluskey
2019 Baker JR, Sakoff JA, McCluskey A, 'The aryl hydrocarbon receptor (AhR) as a breast cancer drug target', MEDICINAL RESEARCH REVIEWS, 40 972-1001 (2019)
DOI 10.1002/med.21645
Citations Scopus - 1Web of Science - 1
Co-authors Adam Mccluskey, Jennette Sakoff
2019 Russell CC, Stevens A, Young KA, Baker JR, McCluskey SN, Khazandi M, et al., 'Discovery of 4,6-bis(2-((E)-benzylidene)hydrazinyl)pyrimidin-2-Amine with Antibiotic Activity.', ChemistryOpen, 8 896-907 (2019) [C1]
DOI 10.1002/open.201800241
Co-authors Cecilia Russell, Adam Mccluskey
2018 Baker JR, Gilbert J, Paula S, Zhu X, Sakoff JA, McCluskey A, 'Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro', CHEMMEDCHEM, 13 1447-1458 (2018) [C1]
DOI 10.1002/cmdc.201800256
Citations Scopus - 6Web of Science - 6
Co-authors Jennette Sakoff, Adam Mccluskey
2018 Cossar PJ, Baker JR, Cain N, McCluskey A, 'In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of beta-amino alcohols', ROYAL SOCIETY OPEN SCIENCE, 5 (2018) [C1]
DOI 10.1098/rsos.171190
Citations Scopus - 4Web of Science - 4
Co-authors Adam Mccluskey
2018 Ghods A, Gilbert J, Baker JR, Russell CC, Sakoff JA, McCluskey A, 'A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone', Royal Society Open Science, 5 (2018) [C1]

© 2018 The Authors. Bolinaquinone is a natural product that is a structurally complex, cytotoxic sesquiterpene quinone. A scaffold simplification and focused library approach usin... [more]

© 2018 The Authors. Bolinaquinone is a natural product that is a structurally complex, cytotoxic sesquiterpene quinone. A scaffold simplification and focused library approach using a microwave-assisted Suzuki coupling gave 32 bolinaquinone analogues with good-to-excellent cytotoxicity profiles. Mono-arylbenzoquinones, Library A, were preferentially toxic towards BE2-C (neuroblastoma) cells with growth inhibition (GI50) values of 4¿12 µM; only the 3,4-dimethoxyphenyl 23 and 3-biphenyl 28 variants were broad-spectrum active¿HT29 (colon carcinoma), U87 and SJ-G2 (glioblastoma), MCF-7 (breast carcinoma), A2780 (ovarian carcinoma), H460 (lung carcinoma), A431 (skin carcinoma), Du145 (prostate carcinoma), BE2-C (neuroblastoma), MIA (pancreatic carcinoma) and SMA (spontaneous murine astrocytoma). Library B with a second aryl moiety exhibited broad-spectrum cytotoxicity with MCF-7 cells¿ GI50 values of 5.6 ± 0.7 and 5.1 ± 0.5 µM for 2,5-dimethoxy-3-(naphthalene-1-yl)-6-(naphthalene-3-yl) 33 and 2,5-dimethoxy-3-(biaryl-2-yl)-6-(naphthalene-3-yl) 36, respectively. Similar potencies were also noted with 2,5-dimethoxy-3,6-diphenyl 30 against A2780 (GI50 = 5.9 ± 0.0 µM) and with 2,5-dimethoxy-3-(biaryl-3-yl)-6-(naphthalene-3-yl) 37 against HT29 (GI50 = 5.4 ± 0.4 µM), while the 3,4-dimethoxy mono-aryl analogue 23 exhibited good levels of activity against A2780 (GI50 = 3.8 ± 0.75 µM), the neuroblastoma cell line BE2-C (GI50 = 3 ± 0.35 µM) and SMA (GI50 = 3.9 ± 0.54 µM). Introduction of the amino-substituted Library C gave 2-(naphthalen-1-yl)-5-(naphthalen-3-yl)-3,6-bis(propylamino) 43, with excellent activity against HT29 (0.08 ± 0.0 µM), MCF-7 (0.17 ± 0.1 µM), A2780 (0.14 ± 0.1 µM), A431 (0.11 ± 0.0 µM), Du145 (0.16 ± 0.1 µM), BE2-C (0.08 ± 0.0 µM) and MIA (0.1 ± 0.0 µM).

DOI 10.1098/rsos.171189
Co-authors Cecilia Russell, Jennette Sakoff, Adam Mccluskey
2018 Russell CC, Stevens A, Pi H, Khazandi M, Ogunniyi AD, Young KA, et al., 'Gram-Positive and Gram-Negative Antibiotic Activity of Asymmetric and Monomeric Robenidine Analogues', CHEMMEDCHEM, 13 2573-2580 (2018) [C1]
DOI 10.1002/cmdc.201800463
Citations Scopus - 1Web of Science - 1
Co-authors Adam Mccluskey, Cecilia Russell
2016 Robertson MJ, Horatscheck A, Sauer S, von Kleist L, Baker JR, Stahlschmidt W, et al., '5-Aryl-2-(naphtha-1-yl)sulfonamido-thiazol-4(5H)-ones as clathrin inhibitors', ORGANIC & BIOMOLECULAR CHEMISTRY, 14 11266-11278 (2016) [C1]
DOI 10.1039/c6ob02308h
Citations Scopus - 1Web of Science - 1
Co-authors Adam Mccluskey
2016 Lin AJS, Russell CC, Baker JR, Frailey SL, Sakoff JA, McCluskey A, 'A facile hybrid 'flow and batch' access to substituted 3,4-dihydro-2: H -benzo [b] [1,4]oxazinones', Organic and Biomolecular Chemistry, 14 8732-8742 (2016) [C1]

© The Royal Society of Chemistry 2016. We describe a simple flow chemistry approach to libraries of ethyl 3-oxo-2-(substituted-phenylamino)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-c... [more]

© The Royal Society of Chemistry 2016. We describe a simple flow chemistry approach to libraries of ethyl 3-oxo-2-(substituted-phenylamino)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylates (12a-l) and N-ethyl-3-oxo-2-(substituted-phenylamino)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxamides (13a-l) in 38-87% yields. This scaffold is poorly described in the chemical literature. Screening against a panel of 11 cancer and one normal cell line showed that the amide linked library 13a-l was devoid of toxicity. Whereas the ester linked analogues 12b, 12c, 12g, 12j and 12l were highly cytotoxic with growth inhibition (GI50) values from 0.34 to >50 µM across all cell lines, with the 2-OH-Ph substituted 12l analogue presenting with sub-micromolar potency against the A2780 (ovarian; 0.34 ± 0.04 µM), BEC-2 (glioblastoma; 0.35 ± 0.06 µM), MIA (pancreas; 0.91 ± 0.054 µM) and SMA (murine glioblastoma; 0.77 ± 0.029 µM) carcinoma cell lines. Interestingly, the U87 glioblastoma cell line showed inherent resistance to growth inhibition by all analogues (GI50 32 to >50 µM) while the A2780 cells were highly sensitive (GI50 3.8-0.34 µM), suggesting that the analogues developed herein may be valuable lead compounds for the development of ovarian carcinoma specific cytotoxic agents. The differences in amide versus ester cytotoxicity was consitent with esterase cleaveage to release the cytotoxic warhead.

DOI 10.1039/c6ob01153e
Citations Scopus - 3Web of Science - 3
Co-authors Adam Mccluskey, Cecilia Russell, Jennette Sakoff
Show 6 more journal articles
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 9
United States 3
Germany 1
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Dr Jennifer Baker

Positions

Postdoctoral Reseacher
School of Environmental and Life Sciences
Faculty of Science

Casual Academic
School of Environmental and Life Sciences
Faculty of Science

Casual Lecturer
Learning and Teaching
Academic Division

Casual Lecturer
Learning and Teaching
Academic Division

Casual Academic
School of Environmental and Life Sciences
Faculty of Science

Focus area

Chemistry

Contact Details

Email jennifer.r.baker@newcastle.edu.au
Phone (02) 4921 5464

Office

Room C216c
Building Science Building.
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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