The University of Newcastle, Australia
Available in 2019

Course handbook

Description

This course is designed to examine chemistry at the important interface between the chemical and biological sciences. The basic principles of synthetic and structural chemistry are applied to examination of the synthesis of biologically active molecules and drugs, and the structure, activity and interaction of biomolecules, including metalloproteins and natural products. The course aims to develop an understanding of the key features of the rational design of new medicinal agents. The importance of close links between the biological and chemical sciences will become apparent.

The course forms part of the accredited degree program required for Membership of Royal Australian Chemical Institute Inc. and Chartered Chemist qualifications.


Availability2019 Course Timetables

Callaghan

  • Semester 2 - 2019

Learning outcomes

On successful completion of the course students will be able to:

1. To develop expertise relevant to the professional practice of medicinal and biological chemistry

2. To develop an understanding of the range and chemistry of compounds of biological or medicinal relevance

3. To establish an appreciation of the role of the chemist in investigations of biological molecules

4. To develop an understanding of the role of the chemist in the development of drugs and pharmaceuticals

5. To provide an understanding of the principal tasks for the synthesis or isolation and characterization of natural molecules and proto-drugs

6. To provide experience in the scientific methods employed in natural products, bioinorganic and medicinal chemistry

7. To develop skills in procedures and instrumental methods applied in structure determination of natural molecules

8. To further develop skills in the scientific method of planning, developing, conducting, reviewing and reporting experiments

9. To develop some understanding of the professional, legal and safety responsibilities residing in working with natural and pharmaceutical products


Content

The course involves study of:

  1. Natural Compounds:
  • the isolation of compounds from natural organisms such as bacteria, fungi, plants and invertebrate animals
  • applications of isolated compounds
  1. Metal-containing Natural Compounds:
  • metal ions in natural systems, particularly metalloproteins and metalloenzymes
  • the role of the metal ion in these biomolecules
  • the development of synthetic model systems to mimic natural enzymes
  1. Medicinal Compounds:
  • the range and role of synthetic molecules in medicine
  • current approaches to the chemical synthesis of new drugs
  • current approaches to the rational design and development of new drugs

Requisite

Students must have successfully completed CHEM2310 or CHEM2201 to be enrolled in this course.


Assumed knowledge

CHEM3550Medicinal and Biological ChemistryThis course is designed to examine chemistry at the important interface between the chemical and biological sciences. The basic principles of synthetic and structural chemistry are applied to examination of the synthesis of biologically active molecules and drugs, and the structure, activity and interaction of biomolecules, including metalloproteins and natural products. The course aims to develop an understanding of the key features of the rational design of new medicinal agents. The importance of close links between the biological and chemical sciences will become apparent.

The course forms part of the accredited degree program required for Membership of Royal Australian Chemical Institute Inc. and Chartered Chemist qualifications.FSCITFaculty of Science723School of Environmental and Life Sciences1030005980Semester 2 - 2019CALLAGHANCallaghan2019CHEM2210 and CHEM2310The course involves study of:

Natural Compounds:

the isolation of compounds from natural organisms such as bacteria, fungi, plants and invertebrate animals

applications of isolated compounds

Metal-containing Natural Compounds:

metal ions in natural systems, particularly metalloproteins and metalloenzymes

the role of the metal ion in these biomolecules

the development of synthetic model systems to mimic natural enzymes

Medicinal Compounds:

the range and role of synthetic molecules in medicine

current approaches to the chemical synthesis of new drugs

current approaches to the rational design and development of new drugs YOn successful completion of this course, students will be able to:1To develop expertise relevant to the professional practice of medicinal and biological chemistry2To develop an understanding of the range and chemistry of compounds of biological or medicinal relevance3To establish an appreciation of the role of the chemist in investigations of biological molecules4To develop an understanding of the role of the chemist in the development of drugs and pharmaceuticals5To provide an understanding of the principal tasks for the synthesis or isolation and characterization of natural molecules and proto-drugs6To provide experience in the scientific methods employed in natural products, bioinorganic and medicinal chemistry7To develop skills in procedures and instrumental methods applied in structure determination of natural molecules8To further develop skills in the scientific method of planning, developing, conducting, reviewing and reporting experiments9To develop some understanding of the professional, legal and safety responsibilities residing in working with natural and pharmaceutical products Students must have successfully completed CHEM2310 or CHEM2201 to be enrolled in this course.Written Assignment: Written AssignmentsTutorial / Laboratory Exercises: Laboratory Exercises *Formal Examination: Formal Examination ** This assessment has a compulsory requirement.CallaghanLaboratoryFace to Face On Campus3hour(s)per Week for12Weeks0LectureFace to Face On Campus2hour(s)per Week for13Weeks0TutorialFace to Face On Campus1hour(s)per Week for12Weeks0In order to pass this course, each student must complete ALL of the following compulsory requirements:General Course Requirements:Laboratory: Attendance Requirement - Students must attend a minimum number of these sessions.Students must attend all scheduled laboratory sessionsLaboratory: Induction Requirement - Students must attend and pass the induction requirements before attending these sessions. Course Assessment Requirements:Tutorial / Laboratory Exercises: Attempt / Submission Requirement - Students must attempt/submit this assessment item to pass the course. Tutorial / Laboratory Exercises: Pass Requirement - Students must pass this assessment item to pass the course.All submitted and overall mark of 50 or more to pass coursesFormal Examination: Minimum Grade / Mark Requirement - Students must obtain a specified minimum grade / mark in this assessment item to pass the course.Students must obtain a mark of 40 or more to pass this course.


Assessment items

Written Assignment: Written Assignments

Tutorial / Laboratory Exercises: Laboratory Exercises *

Formal Examination: Formal Examination *

* This assessment has a compulsory requirement.


Compulsory Requirements

In order to pass this course, each student must complete ALL of the following compulsory requirements:

General Course Requirements:

  • Laboratory: Attendance Requirement - Students must attend a minimum number of these sessions. - Students must attend all scheduled laboratory sessions
  • Laboratory: Induction Requirement - Students must attend and pass the induction requirements before attending these sessions.

Course Assessment Requirements:

  • Tutorial / Laboratory Exercises: Attempt / Submission Requirement - Students must attempt/submit this assessment item to pass the course.
  • Tutorial / Laboratory Exercises: Pass Requirement - Students must pass this assessment item to pass the course. - All submitted and overall mark of 50 or more to pass courses
  • Formal Examination: Minimum Grade / Mark Requirement - Students must obtain a specified minimum grade / mark in this assessment item to pass the course. - Students must obtain a mark of 40 or more to pass this course.

Contact hours

Callaghan

Laboratory

Face to Face On Campus 3 hour(s) per Week for 12 Weeks

Lecture

Face to Face On Campus 2 hour(s) per Week for 13 Weeks

Tutorial

Face to Face On Campus 1 hour(s) per Week for 12 Weeks