Dr Ryan Duchatel

Dr Ryan Duchatel

Postdoctoral Fellow

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Dr Ryan John Duchatel is an Early Career Researcher, achieving his PhD in Experimental Pharmacology in November 2018. With a neuroscience focus, he examined the neurobiology, and immune and genetic fingerprints underpinning schizophrenia as characterized by altered neurodevelopment. His PhD focused on why people with schizophrenia have a greater density of neurons within white matter brain tracts compared to the healthy population. His research program was conducted under the hypothesis that the maternal immune system contributes to white matter development following sustained bacterial/viral infections in the antenatal context. His work contributed to the understanding of the development of schizophrenia, through alterations in neurodevelopment during pregnancy, and resulted in five first author publications in leading schizophrenia journals such as NPJ Schizophrenia (IF4.7), Schizophrenia Research (IF4.7) and Progress in Neuro-psychopharmacology and Biological Psychiatry (IF4.3).

Dr Duchatel has since transitioned to the Cancer Signalling Research Group (CSRG) of Dr Matthew Dun as a Post-Doctoral Fellow, based at University of Newcastle, Hunter Medical Research Institute. He guides a team of staff and students investigating the molecular mechanisms underpinning a rare and deadly form of paediatric brain cancer - 'Diffuse Intrinsic Pontine Glioma' or 'DIPG'. Dr Duchatel was instrumental in Dr Dun's establishment of University of Newcastle's program of DIPG research in 2018. The group combines cellular and molecular biology techniques, in vitro and in vivo modelling utilising patient samples, together coupled with high-resolution, quantitative proteomics. Dr Duchatel has recently published commentary of the known (and unknowns) of DIPG signal transduction in Proteomics (IF3.1)

Dr Duchatel is a specialist in DIPG neurosphere in vitro modelling. Trained by world-leading DIPG researchers (Monje - Stanford University USA, Ziegler - Children's Cancer Institute Australia, UNSW, AUS) he leads the patient derived xenograft, in vivo DIPG modelling of the CSRG, necessary for translation of the group's pre-clinical findings to the clinical trial setting.

Dr Duchatel's current research project, in conjunction with field-leading DIPG research collaborators (Nazarian, Mueller - DIPG Research Centre of Excellence, Switzerland) investigates new and improved treatment strategies to overcome the limitations of current investigative therapies for children with DIPG. Primarily focused on inhibitors of cell growth pathways controlled by 'PI3K' (Phosphoinositide 3-kinase), this has led to the first, high-resolution, quantitative proteomic analysis of DIPG, and identified the compensatory signalling pathways activated in response to PI3K inhibition, which are now under investigation for clinical utility.

Dr Duchatel has secured >$200K in DIPG research funding in 2018-2019, including philanthropic funding from the Isabella and Marcus Paediatric Brainstem Tumour Fund ($7000), the McDonald Jones Homes Charitable Foundation ($100,000), Jennie Thomas ($10,000) competitive project grants from the Hunter Medical Research Institute, Australia ($94,000), and industry linkages via Kazia Therapeutics Limited ($10,000).

Dr Duchatel engages with both the scientific and lay communities to further the reach and relevance of his research. As the Deputy Chair of the Hunter Cancer Research Alliance’s (HCRA), Future Leaders Group, and member of the 2020 HCRA symposium committee and community engagement committee, his position affords him the opportunity to raise awareness and profile of cancer research. He serves on the scientific advisory committee of the Hunter Cancer Biobank, Australia. Dr Duchatel’s leadership has seen him supervise two B.Biomed Sci students (one current, one complete with Class 1 Honours) and is presently co-supervisor to one PhD candidate.



Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Biomedical Sciences, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Acute Myeloid Leukaemia
  • Brain Cancer
  • Cancer Biology
  • Diffuse Intrinsic Pontine Glioma
  • Molecular Oncology
  • Neurobiology
  • Neuroscience
  • Schizophrenia

Languages

  • English (Mother)

Fields of Research

Code Description Percentage
110106 Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) 20
111201 Cancer Cell Biology 80

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (8 outputs)

Year Citation Altmetrics Link
2020 Afrin F, Chi M, Eamens AL, Duchatel RJ, Douglas AM, Schneider J, et al., 'Can hemp help? Low-THC cannabis and non-THC cannabinoids for the treatment of cancer', Cancers, 12 (2020) [C1]
DOI 10.3390/cancers12041033
Citations Scopus - 2Web of Science - 1
Co-authors Jennifer Schneider, Andy Eamens, Craig Gedye, Matt Dun
2020 Dun MD, Mannan A, Rigby CJ, Butler S, Toop HD, Beck D, et al., 'Shwachman Bodian Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia', Leukemia, (2020)
DOI 10.1038/s41375-020-0814-0
Co-authors Nikki Verrills, Hubert Hondermarck, Geoffry DeiuliIs, Heather Murray, David Skerrett-Byrne, Matt Dun, Sam Faulkner, Brett Nixon, Anoop Enjeti
2019 Duchatel RJ, Harms LR, Meehan CL, Michie PT, Bigland MJ, Smith DW, et al., 'Reduced cortical somatostatin gene expression in a rat model of maternal immune activation', PSYCHIATRY RESEARCH, 282 (2019) [C1]
DOI 10.1016/j.psychres.2019.112621
Citations Scopus - 1
Co-authors Deborah Hodgson, Paul Tooney, Lauren Harms, Pat Michie, Douglas Smith, Phillip Jobling
2019 Duchatel RJ, Shannon Weickert C, Tooney PA, 'White matter neuron biology and neuropathology in schizophrenia', npj Schizophrenia, 5 1-9 (2019) [C1]
DOI 10.1038/s41537-019-0078-8
Citations Scopus - 3Web of Science - 3
Co-authors Paul Tooney
2019 Duchatel RJ, Jackson ER, Alvaro F, Nixon B, Hondermarck H, Dun MD, 'Signal Transduction in Diffuse Intrinsic Pontine Glioma', PROTEOMICS, 19 (2019) [C1]
DOI 10.1002/pmic.201800479
Citations Scopus - 5Web of Science - 4
Co-authors Hubert Hondermarck, Matt Dun, Brett Nixon
2018 Duchatel RJ, Meehan CL, Harms LR, Michie PT, Bigland MJ, Smith DW, et al., 'Increased complement component 4 (C4) gene expression in the cingulate cortex of rats exposed to late gestation immune activation', SCHIZOPHRENIA RESEARCH, 199 442-444 (2018)
DOI 10.1016/j.schres.2018.03.035
Citations Scopus - 7Web of Science - 5
Co-authors Lauren Harms, Deborah Hodgson, Pat Michie, Douglas Smith, Phillip Jobling, Paul Tooney
2018 Duchatel RJ, Meehan CL, Harms LR, Michie PT, Bigland MJ, Smith DW, et al., 'Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring', Psychiatry Research, 266 175-185 (2018) [C1]

© 2018 Animal models of maternal immune activation study the effects of infection, an environmental risk factor for schizophrenia, on brain development. Microglia activation and c... [more]

© 2018 Animal models of maternal immune activation study the effects of infection, an environmental risk factor for schizophrenia, on brain development. Microglia activation and cytokine upregulation may have key roles in schizophrenia neuropathology. We hypothesised that maternal immune activation induces changes in microglia and cytokines in the brains of the adult offspring. Maternal immune activation was induced by injecting polyriboinosinic:polyribocytidylic acid into pregnant rats on gestational day (GD) 10 or GD19, with brain tissue collected from the offspring at adulthood. We observed no change in Iba1, Gfap, IL1-ß and TNF-a mRNA levels in the cingulate cortex (CC) in adult offspring exposed to maternal immune activation. Prenatal exposure to immune activation had a significant main effect on microglial IBA1-positive immunoreactive material (IBA1+IRM) in the corpus callosum; post-hoc analyses identified a significant increase in GD19 offspring, but not GD10. No change in was observed in the CC. In contrast, maternal immune activation had a significant main effect on GFAP+IRM in the CC at GD19 (not GD10); post-hoc analyses only identified a strong trend towards increased GFAP+IRM in the GD19 offspring, with no white matter changes. This suggests late gestation maternal immune activation causes subtle alterations to microglia and astrocytes in the adult offspring.

DOI 10.1016/j.psychres.2018.05.063
Citations Scopus - 5Web of Science - 4
Co-authors Pat Michie, Lauren Harms, Paul Tooney, Rohan Walker, Douglas Smith, Deborah Hodgson, Phillip Jobling
2016 Duchatel RJ, Jobling P, Graham BA, Harms LR, Michie PT, Hodgson DM, Tooney PA, 'Increased white matter neuron density in a rat model of maternal immune activation - Implications for schizophrenia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 65 118-126 (2016) [C1]

© 2015. Interstitial neurons are located among white matter tracts of the human and rodent brain. Post-mortem studies have identified increased interstitial white matter neuron (I... [more]

© 2015. Interstitial neurons are located among white matter tracts of the human and rodent brain. Post-mortem studies have identified increased interstitial white matter neuron (IWMN) density in the fibre tracts below the cortex in people with schizophrenia. The current study assesses IWMN pathology in a model of maternal immune activation (MIA); a risk factor for schizophrenia. Experimental MIA was produced by an injection of polyinosinic:polycytidylic acid (PolyI:C) into pregnant rats on gestational day (GD) 10 or GD19. A separate control group received saline injections. The density of neuronal nuclear antigen (NeuN<sup>+</sup>) and somatostatin (SST<sup>+</sup>) IWMNs was determined in the white matter of the corpus callosum in two rostrocaudally adjacent areas in the 12week old offspring of GD10 (n=10) or GD19 polyI:C dams (n=18) compared to controls (n=20). NeuN<sup>+</sup> IWMN density trended to be higher in offspring from dams exposed to polyI:C at GD19, but not GD10. A subpopulation of these NeuN<sup>+</sup> IWMNs was shown to express SST. PolyI:C treatment of dams induced a significant increase in the density of SST<sup>+</sup> IWMNs in the offspring when delivered at both gestational stages with more regionally widespread effects observed at GD19. A positive correlation was observed between NeuN<sup>+</sup> and SST<sup>+</sup> IWMN density in animals exposed to polyI:C at GD19, but not controls. This is the first study to show that MIA increases IWMN density in adult offspring in a similar manner to that seen in the brain in schizophrenia. This suggests the MIA model will be useful in future studies aimed at probing the relationship between IWMNs and schizophrenia.

DOI 10.1016/j.pnpbp.2015.09.006
Citations Scopus - 15Web of Science - 11
Co-authors Brett Graham, Paul Tooney, Deborah Hodgson, Phillip Jobling, Pat Michie, Lauren Harms
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Conference (6 outputs)

Year Citation Altmetrics Link
2019 Duchatel R, Jackson E, Patabendige A, Cain J, Tsoli M, Monje M, et al., 'TARGETING PI3K USING THE BLOOD BRAIN BARRIER PENETRABLE INHIBITOR, GDC-0084, FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)', NEURO-ONCOLOGY, San Francisco, CA (2019)
DOI 10.1093/neuonc/noz036.024
Co-authors Matt Dun, Adjanie Patabendige
2019 Afrin F, Chi M, Woldu A, Duchatel R, Dun MD, 'Anti-Acute Myeloid Leukaemia Properties of Low-THC Cannabis', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2019)
Co-authors Matt Dun
2018 Duchatel R, Jackson E, Verrills N, Cain J, Monje M, Alvaro F, Dun M, 'Investigating ACVR1 and PI3K as Novel Therapeutic Targets in H3.1 K27M+Diffuse Intrinsic Pontine Glioma', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)
Co-authors Matt Dun, Nikki Verrills
2018 Staudt D, Duchatel R, Kahl R, Murray H, Scott R, Verrills N, Dun M, 'Development of Novel Model Systems for the Study of Resistance to Targeted Therapies in Acute Myeloid Leukemia', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)
Co-authors Rodney Scott, Matt Dun
2018 Germon Z, Sillar J, Murray H, Duchatel R, Al-mazi J, Verrills N, Dun M, 'Intracellular Oxidative Stress Modulates FLT3 Regulatory Proteins Contributing to Oncogenic Signaling in Acute Myeloid Leukemia', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)
Co-authors Matt Dun, Heather Murray, Nikki Verrills
2015 Duchatel R, Jobling P, Graham B, Harms L, Michie P, Hodgson D, Tooney P, 'Modelling white matter neuron pathology in schizophrenia using maternal immune activation', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015) [E3]
Co-authors Lauren Harms, Pat Michie, Phillip Jobling, Deborah Hodgson, Paul Tooney, Brett Graham
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Grants and Funding

Summary

Number of grants 7
Total funding $240,000

Click on a grant title below to expand the full details for that specific grant.


20192 grants / $36,000

Moving safe and well-tolerated therapies from the bench to the clinic for the treatment of childhood brain cancer$26,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Matt Dun, Doctor Ryan Duchatel, Doctor Frank Alvaro, Dr Javad Nazarian, Dr Michelle Monje
Scheme Research Grant
Role Investigator
Funding Start 2019
Funding Finish 2020
GNo G1901488
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Preclinical research into the potential applications of GDC-0084 in diffuse intrinsic pontine glioma (DIPG)$10,000

Funding body: Kazia Therapeutics Limited

Funding body Kazia Therapeutics Limited
Project Team Doctor Matt Dun, Associate Professor David Ziegler, Doctor Heather Murray, Doctor Ryan Duchatel, Doctor Frank Alvaro
Scheme Research Grant
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1801161
Type Of Funding C3111 - Aust For profit
Category 3111
UON Y

20185 grants / $204,000

Proteomic architecture of diffuse pontine intrinsic glioma$100,000

Funding body: McDonald Jones Charitable Foundation

Funding body McDonald Jones Charitable Foundation
Project Team Doctor Matt Dun, Doctor Frank Alvaro, Doctor Ryan Duchatel, Doctor Heather Murray, Associate Professor David Ziegler
Scheme Postdoctoral fellowship
Role Investigator
Funding Start 2018
Funding Finish 2020
GNo G1801130
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Non-invasive detection of DIPG specific DNA and protein using sequential blood collections$57,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Matt Dun, Doctor Muhammad Fairuz Jamaluddin, Doctor Ryan Duchatel, Doctor Frank Alvaro
Scheme Project Grant
Role Investigator
Funding Start 2018
Funding Finish 2020
GNo G1801235
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Enhancing the efficacy of new inhibitors targeting the PI3K–AKT–mTOR signalling axis for the treatment of high-grade diffuse intrinsic pontine gliomas (DIPG)$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Matt Dun, Doctor Ryan Duchatel, Doctor Adjanie Patabendige
Scheme Project Grant
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo G1801386
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Building international collaborations for DIPG research$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Ryan Duchatel, Doctor Matt Dun
Scheme Jennie Thomas Medical Research Travel Grant
Role Lead
Funding Start 2018
Funding Finish 2018
GNo G1801371
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Targeting oncogenic signalling in DIPG using drugs that cross the blood brain barrier.$7,000

Funding body: Australian Communities Foundation

Funding body Australian Communities Foundation
Project Team Doctor Matt Dun, Doctor Ryan Duchatel, Ms Terina Vale
Scheme Isabella and Marcus Paediatric Brainstem Tumour Fund
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo G1800977
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y
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Research Supervision

Number of supervisions

Completed1
Current2

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2020 Honours Neoantigen immunopeptidomics for the development of immunotherapies for the treatment for the treatment of diffuse intrinsic pontine glioma (DIPG) Biochemistry & Cell Biology, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle Co-Supervisor
2020 PhD Molecular Characterisation of Oncogenic Signalling Networks to Develop Treatment Strategies for Diffuse Intrinsic Pontine Glioma PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2019 Honours In vitro efficacy of ONC201 in diffuse intrinsic pontine glioma (DIPG) Biochemistry & Cell Biology, Faculty of Health and Medicine, University of Newcastle Co-Supervisor
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Dr Ryan Duchatel

Position

Postdoctoral Fellow
Cancer Signalling Group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email ryan.duchatel@newcastle.edu.au
Phone (02) 49854489
Mobile (+61) 419268714

Office

Room LS338
Building Life Science
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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