Dr Megan Jensen

Dr Megan Jensen

Postdoctoral Clinical Researcher

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Dr Jensen is a clinical researcher (PhD, 2013) and Accredited Practicing Dietitian (Bachelor Nutrition & Dietetics, Hons, 2008), currently working in the Centre for Healthy Lungs, University of Newcastle. In 2015, Dr Jensen was listed as a key researcher for the recently established University of Newcastle Priority Research Centre Grow Up Well.  Prior to this position, she completed a 2 year overseas postdoctoral fellowship in Canada, at CHU Sainte-Justine, University of Montreal, under Prof Francine Ducharme, funded by the Canadian Institute of Health Research, exploring the role of vitamin D supplementation in viral-induced preschool wheeze. Dr Jensen's research focuses on randomised controlled nutritional interventions and nutritional assessment in maternal and childhood asthma. Her research areas include a focus on obesity and body composition, having conducted a dietary-induced weight loss trial in children with asthma and characterisation of paediatric obese asthma. Her current research involves the assessment of dietary intake and nutritional status in women with asthma during pregnancy and the relationship with outcomes in their offspring.
Dr Jensen serves as the National Convenor for both the Research Discussion Group and the Paediatric and Maternal Health Discussion Group for the Dietitians Association of Australia. She also currently serves as Chair of the Student Mentor Committee for the Nutrition Society of Australia (NSA), having previously served as co-chair and co-secretary for the local Newcastle branch of the NSA. Dr Jensen also serves as an Associate Editor for the journal Trials.


Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Nutrition and Dietetics (Honours), University of Newcastle

Keywords

  • asthma
  • body composition
  • clinical trials
  • dietitian
  • nutrition
  • obesity
  • pediatrics
  • pregnancy
  • vitamin D

Fields of Research

Code Description Percentage
110203 Respiratory Diseases 60
111199 Nutrition and Dietetics not elsewhere classified 20
111403 Paediatrics 20

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Clinical Researcher University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
Postdoctoral Clinical Researcher University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/04/2013 - 31/03/2015 Postdoctoral Research Fellow Hospital Sainte-Justine
Pediatrics
Canada

Awards

Award

Year Award
2017 Professional Development Grant
University of Newcastle - Faculty of Health and Medicine, School of Medicine and Public Health
2017 2016 Paper of the Year
Priority Research Centre Grow Up Well, University of Newcastle
2016 Allergy & Asthma SIG/ Asthma Australia Best Oral Presentation Award
The Thoracic Society of Australia & New Zealand
2016 Paper of the Year
School of Medicine & Public Health, Faculty of Health & Medicine, University of Newcastle | Australia
2016 Thoracic Society Australia New Zealand / Japanese Respiratory Society Early Career Development Award
Japanese Respiratory Society
2016 Thoracic Society Australia New Zealand Peter Phelan Pediatric Travel Award
The Thoracic Society of Australia & New Zealand
2015 Career Development Award
Priority Research Centre for Asthma and Respiratory Disease
2011 Education Prize
Hunter Medical Research Institute & Hunter Children’s Research Foundation
2008 Vice-Chancellor Honours scholarship
The University of Newcastle

Distinction

Year Award
2013 Rising Researcher
Canadian Child Health Clinician Scientist Program & Council for Canadian Child Health Research
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (30 outputs)

Year Citation Altmetrics Link
2017 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Lifestyle Risk Factors for Weight Gain in Children with and without Asthma.', Children (Basel), 4 (2017)
DOI 10.3390/children4030015
Citations Web of Science - 1
Co-authors Clare Collins, Peter Gibson, Lisa Wood
2017 McLoughlin RF, Berthon BS, Jensen ME, Baines KJ, Wood LG, 'Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis.', Am J Clin Nutr, (2017)
DOI 10.3945/ajcn.117.156265
Co-authors Lisa Wood, Katherine Baines
2017 Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Kerley CP, et al., 'Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data.', Lancet Respir Med, (2017)
DOI 10.1016/S2213-2600(17)30306-5
2017 Murphy VE, Jensen ME, Gibson PG, 'Asthma during Pregnancy: Exacerbations, Management, and Health Outcomes for Mother and Infant', SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 38 160-173 (2017)
DOI 10.1055/s-0037-1600906
Co-authors Vanessa Murphy, Peter Gibson
2017 Murphy VE, Jensen ME, Powell H, Gibson PG, 'Influence of Maternal Body Mass Index and Macrophage Activation on Asthma Exacerbations in Pregnancy.', J Allergy Clin Immunol Pract, 5 981-987.e1 (2017)
DOI 10.1016/j.jaip.2017.03.040
Citations Web of Science - 1
Co-authors Peter Gibson, Vanessa Murphy
2017 Burrows TL, Rollo ME, Williams R, Wood LG, Garg ML, Jensen M, Collins CE, 'A Systematic Review of Technology-Based Dietary Intake Assessment Validation Studies That Include Carotenoid Biomarkers', NUTRIENTS, 9 (2017) [C1]
DOI 10.3390/nu9020140
Co-authors Clare Collins, Tracy Burrows, Megan Rollo, Manohar Garg, Lisa Wood
2016 Murphy VE, Jensen ME, Mattes J, Hensley MJ, Giles WB, Peek MJ, et al., 'The Breathing for Life Trial: a randomised controlled trial of fractional exhaled nitric oxide (FENO)-based management of asthma during pregnancy and its impact on perinatal outcomes and infant and childhood respiratory health', BMC PREGNANCY AND CHILDBIRTH, 16 (2016)
DOI 10.1186/s12884-016-0890-3
Citations Scopus - 1Web of Science - 1
Co-authors John Attia, Joerg Mattes, Vanessa Murphy, Michael Hensley, Peter Gibson
2016 Ashman AM, Collins CE, Hure AJ, Jensen M, Oldmeadow C, 'Maternal diet during early childhood, but not pregnancy, predicts diet quality and fruit and vegetable acceptance in offspring', Maternal and Child Nutrition, 12 579-590 (2016) [C1]

© 2014 John Wiley & Sons Ltd Studies have identified prenatal flavour exposure as a determinant of taste preferences in infants; however, these studies have focused on rela... [more]

© 2014 John Wiley & Sons Ltd Studies have identified prenatal flavour exposure as a determinant of taste preferences in infants; however, these studies have focused on relatively small samples and limited flavours. As many parents struggle with getting children to accept a variety of nutritious foods, a study of the factors influencing food acceptance is warranted. The objective of this study was to determine whether exposure to a wider variety of fruit and vegetables and overall higher diet quality in utero results in acceptance of a greater variety of these foods and better diet quality for offspring during childhood. This study is a secondary data analysis of pregnant women (n = 52) and their resulting offspring recruited for the Women and Their Children's Health study in NSW, Australia. Dietary intake of mothers and children was measured using food frequency questionnaires. Diet quality and vegetable and fruit variety were calculated using the Australian Recommended Food Score and the Australian Chil d and Adolescent Recommended Food Score. Associations between maternal and child diet quality and variety were assessed using Pearson's correlations and the total effect of in utero maternal pregnancy diet on childhood diet was decomposed into direct and indirect effect using mediation analysis. Maternal pregnancy and post-natal diet were both correlated with child diet for overall diet quality and fruit and vegetable variety (P < 0.001). Mediation analyses showed that the indirect effect of maternal pregnancy diet on child diet was mediated through maternal post-natal diet, particularly for fruit (P = 0.045) and vegetables (P = 0.055). Nutrition intervention should therefore be aimed at improving diet quality and variety in mothers with young children, in order to subsequently improve eating habits of offspring.

DOI 10.1111/mcn.12151
Citations Scopus - 5Web of Science - 2
Co-authors Christopher Oldmeadow, Clare Collins, Alexis Hure
2016 Jensen ME, Ducharme FM, Théorêt Y, Bélanger AS, Delvin E, 'Data in support for the measurement of serum 25-hydroxyvitamin D (25OHD) by tandem mass spectrometry', Data in Brief, 8 925-929 (2016)

© 2016. This article provides data and a method related to a research paper entitled &quot;Assessing vitamin D nutritional status: is capillary blood adequate?&quot; (Jensen et a... [more]

© 2016. This article provides data and a method related to a research paper entitled "Assessing vitamin D nutritional status: is capillary blood adequate?" (Jensen et al., 2016) [1]. Circulating 25OHD, the accepted biomarker of the vitamin D nutritional status, is routinely measured by automated immunoassays, that although may be performed in hospital central laboratories, often suffer from a lack of specificity with regards to the different vitamin D metabolites, "Measurement of circulating 25-hydroxyvitamin D: a historical review" (Le Goff et al., 2015) [2] . Mass spectrometry offers this specificity. This article describes the performance of an in-house tandem mass spectrometry method for the individual measurement of 25OHD 3 , 25OHD 2 and 3-épi-25OHD 3 .

DOI 10.1016/j.dib.2016.07.017
2016 Ducharme FM, Jensen ME, Mendelson MJ, Parkin PC, Desplats E, Zhang X, Platt R, 'Asthma Flare-up Diary for Young Children to monitor the severity of exacerbations', Journal of Allergy and Clinical Immunology, 137 744-749.e6 (2016)

© 2015 American Academy of Allergy, Asthma &amp; Immunology. Background Few instruments exist to ascertain the severity of a preschool-aged child&apos;s asthma exacerbations ma... [more]

© 2015 American Academy of Allergy, Asthma & Immunology. Background Few instruments exist to ascertain the severity of a preschool-aged child's asthma exacerbations managed at home. Objective We sought to develop and validate a functional status instrument to assess asthma exacerbation severity in preschoolers. Methods The parent-completed Asthma Flare-up Diary for Young Children (ADYC), which was developed systematically, comprises 17 items, each scored from 1 (best) to 7 (worst). The ADYC was completed daily from the onset of an upper respiratory tract infection (URTI) until asthma symptom resolution; the cumulative daily score was reported. The ADYC was examined for key psychometric properties in a randomized placebo-controlled trial of pre-emptive high-dose fluticasone in preschoolers with URTI-induced asthma. Results In 121 children aged 2.7 ± 1.1 years (59.5% male), the ADYC's internal consistency (Cronbach a =.97), feasibility (97% completion), and test-retest reliability (r = 0.71; 95% CI, 0.59-0.80) were demonstrated. The ADYC was responsive to change between 2 consecutive days (Guyatt statistic = 0.77) with a minimal important difference of 0.22 (0.17-0.27). Of 871 episodes, the cumulative ADYC score was significantly higher during exacerbations than during URTIs (mean difference [MD], 7.6; 95% CI, 6.4-8.9) and for exacerbations with an acute-care visit (MD, 9.1; 95% CI, 7.6-10.7), systemic corticosteroids (MD, 10.1; 95% CI, 8.3-12.0), and hospitalization (MD, 6.8; 95% CI, 2.9-10.7) versus those without. In children receiving fluticasone, the ADYC score was significantly lower versus that in the placebo group (MD, 5.1; 95% CI, 1.8-8.3). Conclusions The 17-item ADYC proved feasible, responsive to day-to-day changes, and discriminative across exacerbations of different severities. In a trial testing effective therapy in preschoolers, it identified a significant reduction in asthma exacerbation severity.

DOI 10.1016/j.jaci.2015.07.028
Citations Scopus - 2
2016 Jensen ME, Mendelson MJ, Desplats E, Zhang X, Platt R, Ducharme FM, 'Caregiver's functional status during a young child's asthma exacerbation: A validated instrument', Journal of Allergy and Clinical Immunology, 137 782-788.e6 (2016)

© 2015 American Academy of Allergy, Asthma &amp; Immunology. Background Few instruments exist to measure caregivers&apos; functional status during a young child&apos;s asthma e... [more]

© 2015 American Academy of Allergy, Asthma & Immunology. Background Few instruments exist to measure caregivers' functional status during a young child's asthma exacerbation. Objective We sought to develop and validate a measure of caregivers' functional status during a preschooler's asthma exacerbation. Methods The psychometric properties of the 21-item questionnaire Effects of a Young Child's Asthma Flare-up on the Parents (ECAP) were tested in a randomized placebo-controlled trial of pre-emptive high-dose fluticasone in preschoolers with virus-induced asthma. Caregivers completed the ECAP questionnaire on the last day their child exhibited symptoms of an upper respiratory tract infection or asthma exacerbation (episode). The mean of each item, scored on a scale of 1 (best) to 7 (worst), provided the ECAP score. Results Ninety-three preschoolers (2.5 ± 1.0 years old; 62.4% male) experienced 878 episodes. Feasibility (80% questionnaire return rate; 90% completion) and internal consistency (Cronbach a = 0.97) were high. Of 628 episodes with a completed ECAP questionnaire, 621 (98.9%) had data on exacerbations, and 609 (97.0%) had data on health care use. The ECAP score was significantly higher for children experiencing an asthma exacerbation versus those who were not (mean difference, 0.8; 95% CI, 0.6-1.0) and for episodes resulting versus not resulting in an emergency visit (mean difference, 1.2; 95% CI, 1.0-1.4), systemic corticosteroid use (mean difference, 1.4; 95% CI, 1.1-1.7), or hospitalization (mean difference, 1.9; 95% CI, 1.4-2.5). The ECAP score was significantly lower in children treated with flutic asone versus those treated with placebo (mean difference, -0.7; 95% CI, -1.1 to -0.3). Conclusions The 21-item ECAP questionnaire, showing high feasibility, internal consistency, discriminative validity, and responsiveness, has the psychometric properties to serve as a validated outcome to measure the burden of preschoolers' asthma exacerbations on their caregivers' functional status.

DOI 10.1016/j.jaci.2015.08.031
Citations Scopus - 2
2016 Jensen ME, Mailhot G, Alos N, Rousseau E, White JH, Khamessan A, Ducharme FM, 'Vitamin D intervention in preschoolers with viral-induced asthma (DIVA): A pilot randomised controlled trial', Trials, 17 (2016)

© 2016 Jensen et al. Background: Trials in school-aged children suggest vitamin D supplementation reduces asthma exacerbations. Primary aim: to ex amine whether vitamin D 3 (100... [more]

© 2016 Jensen et al. Background: Trials in school-aged children suggest vitamin D supplementation reduces asthma exacerbations. Primary aim: to ex amine whether vitamin D 3 (100,000 IU) rapidly raises serum 25-hydroxyvitamin D (25OHD) =75 nmol/L in asthmatic preschoolers. Methods: In a double-blind, randomised, placebo-controlled trial, preschool-aged children with asthma received 100,000 IU vitamin D 3 (intervention) or placebo (control), followed by 400 IU vitamin D 3 daily for 6 months. Serum 25OHD was measured at baseline, 10 days, 3 and 6 months. Outcomes included the group difference in 25OHD change from baseline at 3 months (¿25OHD); the proportion of children with 25OHD =75 nmol/L at 3 months; the pattern in serum vitamin D over 6 months; the proportion of children with hypercalciuria at any time point (safety); and group rates for oral corticosteroids. Continuous outcomes were analysed using generalised linear mixed models and group rate ratios of events per child were assessed using a Poisson distribution model. Results: Twenty-two children were randomised (intervention:11; control:11) during winter. At 3 months, the group difference in ¿25OHD (7.2 nmol/L; 95 % CI: -13.7, 28.1) was not significant; yet, 100 % versus 54.5 % (intervention versus control) had serum 25OHD =75 nmol/L. There was a significant group difference in ¿25OHD at 10 days (110.3 nmol/L; 95 % CI: 64.0, 156.6). One child in each group had transient hypercalciuria at 10 days. Group oral corticosteroids rates were 0.82 and 1.18/child, intervention versus control (rate ratio = 0.68; 95 % CI: 0.30, 1.62; non-significant). Conclusions: Following 100,000 IU vitamin D 3 , all children reached serum 25OHD =75 nmol/L, compared with half who received placebo. Daily supplementation, sun exposure and insufficient power may explain the absence of a significant 3-month group difference in ¿25OHD. No clinically important alterations in bone metabolism biomarkers occurred. Group oral corticosteroid rates will inform sample size calculations for the larger trial. ( NCT01999907 , 25 November 2013).

DOI 10.1186/s13063-016-1483-1
Citations Scopus - 4
2016 Martineau AR, Cates CJ, Urashima M, Jensen M, Griffiths AP, Nurmatov U, et al., 'Vitamin D for the management of asthma', COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (2016) [C1]
DOI 10.1002/14651858.CD011511.pub2
Citations Scopus - 26Web of Science - 4
2016 Jensen ME, Ducharme FM, Théorêt Y, Bélanger AS, Delvin E, 'Assessing vitamin D nutritional status: Is capillary blood adequate?', Clinica Chimica Acta, 457 59-62 (2016) [C1]

© 2016 Elsevier B.V. Background: Venous blood is the usual sample for measuring various biomarkers, including 25-hydroxyvitamin D (25OHD). However, it can prove challenging in in... [more]

© 2016 Elsevier B.V. Background: Venous blood is the usual sample for measuring various biomarkers, including 25-hydroxyvitamin D (25OHD). However, it can prove challenging in infants and young children. Hence the finger-prick capillary collection is an alternative, being a relatively simple procedure perceived to be less invasive. We elected to validate the use of capillary blood sampling for 25OHD quantification by liquid chromatography tandem-mass spectrometry (LC/MS-MS). Methods: Venous and capillary blood samples were simultaneously collected from 15 preschool-aged children with asthma 10 days after receiving 100,000 IU of vitamin-D 3 or placebo and 20 apparently healthy adult volunteers. 25OHD was measured by an in-house LC/MS-MS method. Results: The venous 25OHD values varied between 23 and 255 nmol/l. The venous and capillary blood total 25OHD concentrations highly correlated (r 2 = 0.9963). The mean difference (bias) of capillary blood 25OHD compared to venous blood was 2.0 (95% CI: -7.5, 11.5) nmol/l. Conclusion: Our study demonstrates excellent agreement with no evidence of a clinically important bias between venous and capillary serum 25OHD concentrations measured by LC/MS-MS over a wide range of values. Under those conditions, capillary blood is therefore adequate for the measurement of 25OHD.

DOI 10.1016/j.cca.2016.03.020
Citations Scopus - 1
2015 Periyalil HA, Wood LG, Scott HA, Jensen ME, Gibson PG, 'Macrophage activation, age and sex effects of immunometabolism in obese asthma', European Respiratory Journal, 45 388-395 (2015) [C1]

Copyright © ERS 2015. Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and se... [more]

Copyright © ERS 2015. Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometabolism in obese asthma. Obese and non-obese asthmatic children and adults underwent spirometry, body composition assessment by dual energy X-ray absorptiometry and measurement of serum soluble CD163 (sCD163), tryptase, C-reactive protein (CRP) and other adipocytokines. Plasma CRP (p < 0.01) and leptin (p < 0.01) were elevated in obese asthmatic adults, and sCD163 (p=0.003) was elevated in obese asthmatic children. We observed significantly higher sCD163 in obese female children compared to obese female adults and male children, and higher CRP in obese female adults compared to obese male children and adults. Serum tryptase concentrations were not significantly different across age groups. sCD163 positively correlated with the proportion of android fat in obese female children (r=0.70, p=0.003) and obese female adults (r=0.65, p=0.003). In obese female children, sCD163 was inversely associated with forced expiratory volume in 1 s % predicted (r=-0.55, p=0.02) and was positively associated with the Asthma Control Questionnaire (r=0.57, p=0.02). Obese children with asthma have sex-specific macrophage activation, which may contribute to worse asthma control and lung function. The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level.

DOI 10.1183/09031936.00080514
Citations Scopus - 11Web of Science - 11
Co-authors Lisa Wood, Hayley Scott, Peter Gibson
2015 Burrows TL, Williams R, Rollo M, Wood L, Garg ML, Jensen M, Collins CE, 'Plasma carotenoid levels as biomarkers of dietary carotenoid consumption: A systematic review of the validation studies', Journal of Nutrition and Intermediary Metabolism, 2 15-64 (2015) [C1]

© 2015 The Authors. Published by Elsevier Ltd. Background Previous research has demonstrated that plasma carotenoids are a reliable biomarker of usual fruit and vegetable intake.... [more]

© 2015 The Authors. Published by Elsevier Ltd. Background Previous research has demonstrated that plasma carotenoids are a reliable biomarker of usual fruit and vegetable intake. The review aims were to synthesize (i) the mean dietary intake and (ii) plasma concentrations of carotenoids reported from validation studies (iii) compare the strength of the relationship between the two, measured using different dietary assessment methods. Methods Six databases were used to locate studies that included: adult populations, assessment of dietary intake, measurement of plasma carotenoids and reported the comparison between the two measures. Results One hundred and forty-two studies were included with 95,480 participants, the majority of studies were cross-sectional (n = 86), with randomized controlled trials (RCTs) (n = 18), 14 case-control studies and 13 cohorts. The most common reported dietary carotenoid and plasma carotenoid was lycopene: weighted dietary mean intake (4555.4 ug/day), and plasma concentration 0.62 umol/L (95% CI: 0.61, 0.63, n = 56studies. The strongest weighted correlation between the two measures was found for cryptoxanthin (r = 0.38, 95% CI 0.34, 0.42) followed by a-carotene (r = 0.34, 95% CI 0.31, 0.37). Conclusion This review summarizes typical dietary intakes and plasma concentrations and their expected associations based on validation studies conducted to date which provides a benchmark for future validation studies.

DOI 10.1016/j.jnim.2015.05.001
Citations Scopus - 6
Co-authors Megan Rollo, Lisa Wood, Tracy Burrows, Manohar Garg, Clare Collins
2014 O'Brien KM, Hutchesson MJ, Jensen M, Morgan P, Callister R, Collins CE, 'Participants in an online weight loss program can improve diet quality during weight loss: a randomized controlled trial.', Nutrition journal, 13 82 (2014) [C1]
DOI 10.1186/1475-2891-13-82
Co-authors Clare Collins, Robin Callister, Melinda Hutchesson, Philip Morgan
2014 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Lean mass, not fat mass, is associated with lung function in male and female children with asthma', Pediatric Research, 75 93-98 (2014) [C1]

Background:Whether body composition is associated with lung function in asthmatic children has not been investigated. This study aimed to primarily investigate whether BMI z-score... [more]

Background:Whether body composition is associated with lung function in asthmatic children has not been investigated. This study aimed to primarily investigate whether BMI z-score and body composition were associated with respiratory function in asthmatic children.Methods:In a cross-sectional study, male (n = 27; mean age: 11.9 y (SD: 2.3)) and female (n = 21; mean age: 13.6 y (SD: 2.2)) asthmatic children underwent clinical assessment.Results:BMI z-score was associated with forced expiratory volume in 1 s (FEV 1 ; r = 0.458), forced vital capacity (FVC; r = 0.477), and total lung capacity (TLC; r = 0.451) in males only (P < 0.05). Total lean mass was associated with FEV 1 (r = 0.655), FVC (r = 0.562), and TLC (r = 0.635) in males, as was thoracic lean mass (FEV 1 (r = 0.573), FVC (r = 0.526), and TLC (r = 0.497); P < 0.05). TLC was associated with total (r = 0.522) and thoracic (r = 0.532) lean mass in females (P < 0.05). Fat mass was not associated with lung function in this group.Conclusion:Lean mass, not fat mass, is associated with lung function in children with asthma. The positive association between BMI z-score and respiratory function in male children is driven by lean mass. Although body weight can be easily monitored in the clinical setting, body composition can provide important information. Future research exploring lean mass and lung function associations could inform future interventions. Copyright © 2014 International Pediatric Research Foundation, Inc.

DOI 10.1038/pr.2013.181
Citations Scopus - 2Web of Science - 1
Co-authors Clare Collins, Lisa Wood, Peter Gibson
2014 Scott HA, Jensen ME, Wood LG, 'Dietary interventions in asthma', Current Pharmaceutical Design, 20 1003-1010 (2014) [C1]

Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immu... [more]

Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immune system, via a predominantly IL-5 mediated, eosinophilic pathway. Stimuli such as viruses and bacteria activate the innate immune system, via a predominantly IL-8 mediated, neutrophilic pathway. Asthma has also been demonstrated to involve a systemic inflammatory component. Glucocorticoids are the predominant pharmacological treatment used to control inflammation in asthma. However, compliance with medications can be compromised due to patient concerns about side effects. Hence dietary interventions that target the inflammatory response in asthma have great potential. Various aspects of dietary intake are known to modulate inflammation. Saturated fatty acids can induce an inflammatory response via activation of pattern recognition receptors. Omega-3 fatty acids can be anti-inflammatory, via mechanisms such as modification of eicosanoid production. Antioxidants can have anti-inflammatory effects as they scavenge free radicals, preventing activation of transcription factors including NF-¿B. Chronic excess energy intake can lead to obesity, which augments inflammation due to the release of inflammatory mediators by adipose tissue. Here we review the role of these dietary components in asthma. © 2014 Bentham Science Publishers.

DOI 10.2174/13816128113190990421
Citations Scopus - 9Web of Science - 8
Co-authors Hayley Scott, Lisa Wood
2014 Blomfield RL, Collins CE, Hutchesson MJ, Young MD, Jensen ME, Callister R, Morgan PJ, 'Impact of self-help weight loss resources with or without online support on the dietary intake of overweight and obese men: The SHED-IT randomised controlled trial', Obesity Research and Clinical Practice, 8 e476-e487 (2014) [C1]

©2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. Background: Obese men are more likely to have poor dietary patterns com... [more]

©2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. Background: Obese men are more likely to have poor dietary patterns compared to women, increasing diet-related chronic disease risk. The impact of a male-only weight loss intervention on dietary intakes is under-evaluated. The aim was to deter-mine whether overweight/obese men randomised to self-help paper-based resources with or without online support, achieved greater improvements in diet compared with Wait-list controls at 3 and 6 months following a gender tailored weight-loss intervention. Methods: Dietary intake was assessed using a 120-item semi-quantitative food fre-quency questionnaire (FFQ), in a secondary analysis of a three-arm weight lossRCT grounded in Social Cognitive Theory; (1) Resources: gender-tailored weight lossresources (DVD, handbooks, pedometer, tape measure); (2) Online: resources pluswebsite and efeedback, (3) Wait-list control. Results: Energy, total fat, saturated fat, and carbohydrate intakes decreased in theonline group, which differed significantly from controls at 3- and 6-month follow-up(P < 0.05). There was a significant reduction in energy, fat and carbohydrate intakesin the Resource group at 3 and 6 months, but no difference from controls (P > 0.05).In the online group there was an increase in %energy from core foods and decreasein %energy from energy-dense nutrient-poor foods (P < 0.05) that was significantlydifferent compared to controls at 3 and 6 months (P < 0.05). Conclusion: Results suggest that men randomised to the SHED-IT intervention armswere able to implement key dietary messages up to 6 months compared to con-trols. Future interventions should include targeted and gender-tailored messages asa strategy to improve mens dietary intake within weight loss interventions.© 2013 Asian Oceanian Association for the Study of Obesity.

DOI 10.1016/j.orcp.2013.09.004
Citations Scopus - 5Web of Science - 5
Co-authors Myles Young, Robin Callister, Melinda Hutchesson, Philip Morgan, Clare Collins
2013 Jensen ME, Wood LG, Williams RB, Collins CE, 'Associations between sleep, dietary intake and physical activity in children: systematic review', JBI Database of Systematic Reviews and Implementation Reports, 11 227-262 (2013) [C1]
Co-authors Lisa Wood, Clare Collins
2013 Al-jadani HM, Patterson A, Sibbritt D, Hutchesson MJ, Jensen ME, Collins CE, 'Diet quality, measured by fruit and vegetable intake, predicts weight change in young women.', Journal of Obesity, 2013 (2013) [C1]
DOI 10.1155/2013/525161
Citations Scopus - 20
Co-authors Amanda Patterson, Melinda Hutchesson, Clare Collins
2013 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Airway and systemic inflammation in obese children with asthma', EUROPEAN RESPIRATORY JOURNAL, 42 1012-1019 (2013) [C1]
DOI 10.1183/09031936.00124912
Citations Scopus - 32Web of Science - 25
Co-authors Peter Gibson, Lisa Wood, Clare Collins
2013 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Diet-induced weight loss in obese children with asthma: a randomized controlled trial', CLINICAL AND EXPERIMENTAL ALLERGY, 43 775-784 (2013) [C1]
DOI 10.1111/cea.12115
Citations Scopus - 33Web of Science - 32
Co-authors Peter Gibson, Lisa Wood, Clare Collins
2013 Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG, 'Increased sleep latency and reduced sleep duration in children with asthma', SLEEP AND BREATHING, 17 281-287 (2013) [C1]
DOI 10.1007/s11325-012-0687-1
Citations Scopus - 10Web of Science - 8
Co-authors Peter Gibson, Lisa Wood, Clare Collins
2013 Ho M, Jensen ME, Burrows T, Neve M, Garnett SP, Baur L, et al., 'Best practice dietetic management of overweight and obese children and adolescents: a 2010 update of a systematic review', JBI Database of Systematic Reviews and Implementation Reports, 11 190-293 (2013)
DOI 10.11124/jbisrir-2013-890
Co-authors Melinda Hutchesson
2013 Collins CE, Jensen ME, Young MD, Callister R, Plotnikoff RC, Morgan PJ, 'Improvement in erectile function following weight loss in obese men: The SHED-IT randomized controlled trial', Obesity Research and Clinical Practice, 7 (2013) [C1]
DOI 10.1016/j.orcp.2013.07.004
Citations Scopus - 4Web of Science - 3
Co-authors Robin Callister, Ron Plotnikoff, Clare Collins, Philip Morgan, Myles Young
2012 Jensen ME, Wood LG, Gibson PG, 'Obesity and childhood asthma - Mechanisms and manifestations', Current Opinion in Allergy and Clinical Immunology, 12 186-192 (2012) [C1]
Citations Scopus - 38Web of Science - 35
Co-authors Peter Gibson, Lisa Wood
2011 Jensen ME, Collins CE, Gibson PG, Wood LG, 'The obesity phenotype in children with asthma', Paediatric Respiratory Reviews, 12 152-159 (2011) [C1]
DOI 10.1016/j.prrv.2011.01.009
Citations Scopus - 24Web of Science - 29
Co-authors Lisa Wood, Peter Gibson, Clare Collins
2011 Jensen ME, Collins CE, Latham N, Wood LG, 'Associations between Sleep Architecture, Dietary Intake and Physical Activity in Children: A Systematic Review. (Protocol)', JBI Library of Systematic Reviews, 9 S37-S51 (2011)
Co-authors Lisa Wood, Clare Collins
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Conference (15 outputs)

Year Citation Altmetrics Link
2016 Jensen ME, Camargo CA, Gibson PG, Mattes J, Murphy VE, 'Maternal Serum Ditamin D Levels \= 75nmol/l During Pregnancy Are Associated With Fewer Adverse Respiratory Outcomes In Infants At 12 Months Of Age', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)
Co-authors Peter Gibson, Vanessa Murphy, Joerg Mattes
2016 Jensen ME, Gibson PG, Garg M, Wood LG, 'Neutrophil Activity Markers Are Reduced Following A High, Versus A Low, Fruit And Vegetable Diet, In Overweight And Obese Adults With Asthma', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)
Co-authors Lisa Wood, Peter Gibson
2014 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Sleep, Diet, Activity, And Metabolic Outcomes In Children With And Without Asthma: A Cross-Sectional Study', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
Co-authors Peter Gibson, Lisa Wood, Clare Collins
2014 Periyalil H, Scott H, Jensen M, Wood L, Gibson P, 'MACROPHAGE ACTIVATION IS A DETERMINANT OF DEVELOPMENTAL EFFECTS OF IMMUNOMETABOLISM IN OBESE ASTHMA', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_7
Co-authors Peter Gibson, Hayley Scott, Lisa Wood
2013 Collins CE, Jensen MJ, Young MD, Callister R, Plotnikoff RC, Morgan PJ, 'Erectile function improves in obese men following weight loss during the SHED-IT randomised controlled trial', Obesity Research and Clinical Practice (2013) [E3]
Co-authors Myles Young, Robin Callister, Ron Plotnikoff, Philip Morgan, Clare Collins
2012 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Distribution of lean and fat mass differentially affect lung function in children', Abstracts. American Thoracic Society 2012 International Conference (2012) [E3]
Co-authors Clare Collins, Lisa Wood, Peter Gibson
2012 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Systemic inflammation and clinical asthma outcomes in obese and non-obese children: A cross-sectional study', Abstracts. American Thoracic Society 2012 International Conference (2012) [E3]
Co-authors Lisa Wood, Peter Gibson, Clare Collins
2011 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Dietary induced weight loss improves asthma control and lung function after 10 weeks in obese children and adolescents with asthma', Australasian Medical Journal (2011) [E3]
Co-authors Clare Collins, Peter Gibson, Lisa Wood
2011 Jensen ME, Gibson PG, Collins CE, Wood LG, 'Lean mass is positively associated with respiratory function in male asthmatic children', Australasian Medical Journal (2011) [E3]
Co-authors Clare Collins, Peter Gibson, Lisa Wood
2011 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Characterising the obese phenotype in asthmatic children and adolescents', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Clare Collins, Lisa Wood, Peter Gibson
2011 Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG, 'Gender differences in sleep duration & sleep quality in children with & without asthma using polysomnography', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Lisa Wood, Clare Collins, Peter Gibson
2011 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Results from a ten week pilot weight loss intervention in obese asthmatic children and adolescents', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Clare Collins, Peter Gibson, Lisa Wood
2010 Jensen ME, Gibson PG, Collins CE, Hilton JM, Wood LG, 'Body composition may be associated with systemic and airway inflammation in children with asthma', Obesity Research and Clinical Practice (2010) [E3]
Co-authors Peter Gibson, Clare Collins, Lisa Wood
2010 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Obesity is associated with increased airway inflammation in children with asthma', Respirology (2010) [E3]
Co-authors Peter Gibson, Clare Collins, Lisa Wood
2010 Jensen ME, Collins CE, Gibson PG, Hilton JM, Wood LG, 'Obesity affects airway inflammation in asthmatic children', Nutrition & Dietetics (2010) [E3]
Co-authors Lisa Wood, Peter Gibson, Clare Collins
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Grants and Funding

Summary

Number of grants 19
Total funding $3,956,489

Click on a grant title below to expand the full details for that specific grant.


20173 grants / $3,426,889

Vitamin D In the prevention of Viral-induced Asthma of preschoolers (DIVA): a multicentre randomized controlled trial$3,404,389

Funding body: Canadian Institutes of Health Research (CIHR)

Funding body Canadian Institutes of Health Research (CIHR)
Scheme Project Grant
Role Investigator
Funding Start 2017
Funding Finish 2021
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Nutritional status and exacerbation risk in pregnant women with asthma$20,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Megan Jensen, Doctor Vanessa Murphy, Emeritus Professor Michael Hensley
Scheme Research Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1700387
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The relationship between Vitamin D levels during pregnancy in women with asthma and infant respiratory outcomes$2,500

Funding body: Faculty of Health and Medicine, University of Newcastle

Funding body Faculty of Health and Medicine, University of Newcastle
Scheme Strategic Pilot Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding Internal
Category INTE
UON N

20166 grants / $67,445

Changes in the gut microbiome induced by dietary intervention in children with asthma$25,000

Funding body: Priority Research Centre Grow Up Well, University of Newcastle

Funding body Priority Research Centre Grow Up Well, University of Newcastle
Project Team

Wood LG, Jensen ME, Starkey M, Nightingale S, Mattes J, Collinson A

Scheme Pilot Grant
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding Internal
Category INTE
UON N

Airway resistance, body composition and wheeze in young children at high risk of asthma$21,745

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Megan Jensen, Doctor Vanessa Murphy, Emeritus Professor Michael Hensley
Scheme Research Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1600597
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Peter Phelan Travel Award$7,500

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team Doctor Megan Jensen
Scheme Peter Phelan Travel Award
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1600594
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Vitamin D and Obesity in Childhood Asthma (VOCA)$5,000

Funding body: Priority Research Centre Grow Up Well, University of Newcastle

Funding body Priority Research Centre Grow Up Well, University of Newcastle
Project Team

Jensen ME

Scheme Strategic Funding
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding Internal
Category INTE
UON N

Dual Energy X-ray Absorptiometry (DEXA) software upgrade: pediatric$4,200

Funding body: The University of Newcastle - Faculty of Health and Medicine

Funding body The University of Newcastle - Faculty of Health and Medicine
Project Team

Jensen ME, Berthon BS

Scheme Equipment Round
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding Internal
Category INTE
UON N

Dietary intake during pregnancy and lactation: associations with maternal and infant respiratory outcomes$4,000

Funding body: The University of Newcastle - Faculty of Health and Medicine

Funding body The University of Newcastle - Faculty of Health and Medicine
Project Team

Jensen ME

Scheme Strategic ECR Pilot Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding Internal
Category INTE
UON N

20155 grants / $251,675

Improving diet quality to reduce risk of asthma attacks in children$120,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Lisa Wood, Professor Joerg Mattes, Conjoint Professor Peter Wark, Doctor Katie Baines, Doctor Megan Jensen
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo G1500957
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Vitamin D In the prevention of Viral-induced Asthma of pre-schoolers: a RCT (DIVA)$100,000

Funding body: Canadian Institutes of Health Research (CIHR)

Funding body Canadian Institutes of Health Research (CIHR)
Project Team

Prof Francine Ducharme

Scheme Health Research
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

GC & HPLC service contract$20,000

Funding body: The University of Newcastle - Faculty of Health and Medicine

Funding body The University of Newcastle - Faculty of Health and Medicine
Project Team

LG Wood, PG Gibson, PAB Wark, CE Collins, R Callister, V McDonald, J Mattes, K Baines, J Horvat, L McDonald-Wicks, BS Berthon, ME Jensen

Scheme Equipment Round
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

Adult Forced Oscillation Technique equipment$10,000

Funding body: The University of Newcastle - Faculty of Health and Medicine

Funding body The University of Newcastle - Faculty of Health and Medicine
Project Team

Murphy VE, Gibson PG, Jensen ME

Scheme Equipment Round
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

Joint Annual Scientific Meeting of the Nutrition Society of New Zealand and the Nutrition Society of Australia, Wellington New Zealand, 1-4 December 2015$1,675

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Megan Jensen
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501140
Type Of Funding Internal
Category INTE
UON Y

20141 grants / $100,000

Vitamin D In the prevention of Viral-induced Asthma of pre-schoolers: a RCT (DIVA) $100,000

Funding body: Canadian Institutes of Health Research (CIHR)

Funding body Canadian Institutes of Health Research (CIHR)
Project Team

Prof Francine Ducharme

Scheme Health Research
Role Investigator
Funding Start 2014
Funding Finish 2015
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20131 grants / $36,480

Vitamin D supplementation to prevent exacerbations in children with asthma – a pilot RCT $36,480

Funding body: Thrasher Research Fund

Funding body Thrasher Research Fund
Scheme Early Career Award
Role Lead
Funding Start 2013
Funding Finish 2015
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20121 grants / $4,000

HCRF Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Megan Jensen
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200221
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20101 grants / $20,000

Obesity Risk in Childhood Asthma$20,000

Funding body: Hunter Medical Research Institute (HMRI)

Funding body Hunter Medical Research Institute (HMRI)
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2011
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

20091 grants / $50,000

Obesity and airway inflammation in children with asthma$50,000

Funding body: Hunter Medical Research Institute (HMRI)

Funding body Hunter Medical Research Institute (HMRI)
Project Team

A/Prof Lisa Wood

Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N
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Research Supervision

Number of supervisions

Completed0
Current5

Total current UON EFTSL

PhD1.25

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 PhD Attitudes and Adherence to Asthma Medication During Pregnancy PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Maternal and Early Life Nutritional Status and Respiratory Health Outcomes of the Offspring PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2016 PhD Dietary Fibre As A Modulator of Inflammation In Asthma PhD (Nutritional Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Assessing Acceptability of a Novel Antenatal Asthma Management Approach for Pregnant Women PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Inflammatory gene expression profiling during pregnancy to predict future asthma exacerbations and poor maternal and neonatal outcomes PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
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News

Vitamin D shines in review of asthma management

September 9, 2016

An international asthma review involving University of Newcastle (UON) researcher Dr Megan Jensen has found that Vitamin D supplements can reduce the need for corticosteroid treatment and hospital visits.

Dr Megan Jensen

Positions

Postdoctoral Clinical Researcher
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Postdoctoral Clinical Researcher
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email megan.jensen@newcastle.edu.au
Phone 40420115

Office

Room L2, West Wing, HMRI Bldg
Building HMRI Bldg
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