2023 |
Williams LM, Berthon BS, Stoodley IL, Williams EJ, Wood LG, 'Medicinal Mushroom Extracts from Hericium coralloides and Trametes versicolor Exert Differential Immunomodulatory Effects on Immune Cells from Older Adults In Vitro', Nutrients, 15 2227-2227 [C1]
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Nova |
2022 |
Pinkerton JW, Kim RY, Brown AC, Rae BE, Donovan C, Mayall JR, et al., 'Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 149 1270-1280 (2022) [C1]
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Nova |
2022 |
Eslick S, Thompson C, Berthon B, Wood L, 'Short-chain fatty acids as anti-inflammatory agents in overweight and obesity: a systematic review and meta-analysis.', Nutr Rev, 80 838-856 (2022) [C1]
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Nova |
2022 |
Eslick S, Williams EJ, Berthon BS, Wright T, Karihaloo C, Gately M, Wood LG, 'Weight Loss and Short-Chain Fatty Acids Reduce Systemic Inflammation in Monocytes and Adipose Tissue Macrophages from Obese Subjects', Nutrients, 14 (2022) [C1]
Background: Chronic low-grade systemic inflammation is a characteristic of obesity that leads to various non-communicable diseases. Weight loss and SCFAs are potential strategies ... [more]
Background: Chronic low-grade systemic inflammation is a characteristic of obesity that leads to various non-communicable diseases. Weight loss and SCFAs are potential strategies for attenuating obese systemic inflammation. Methods: Blood samples were collected from 43 obese subjects (BMI = 30 kg/m2) scheduled for laparoscopic bariatric sleeve surgery, 26 obese subjects at follow-up 12¿18 months post-surgery and 8 healthy weight subjects (BMI 18.5¿24.9 kg/m2). Mono-cytes were isolated from blood and adipose tissue macrophages from visceral adipose tissue of obese subjects only. Isolated cells stimulated with 1 ng/mL LPS and treated simultaneously with 300 mM of sodium acetate or 30 mM of sodium propionate or butyrate and supernatant were har-vested after 15 h incubation. TNF-a and IL-6 cytokines were measured via ELISA and mRNA gene expression of FFAR2 and FFAR3, HDAC1, HDAC2 and HDAC9, RELA and NFKB1 and MAPK1 via RT-qPCR. Results: TNF-a and IL-6 production and NFKB1 and RELA mRNA expression were significantly decreased in follow-up subjects compared to baseline. SCFAs significantly reduced TNF-a and IL-6 and altered FFAR and HDAC mRNA expression in monocytes and macrophages from obese subjects. Conclusion: Weight loss and ex vivo SCFA treatments were successful in combatting systemic inflammation in obesity. Results highlighted molecular changes that occur with weight loss and as a result of SCFA treatment.
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Nova |
2022 |
Williams EJ, Berthon BS, Stoodley I, Williams LM, Wood LG, 'Nutrition in Asthma', SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 43 646-661 (2022) [C1]
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Nova |
2022 |
Williams LM, Stoodley IL, Berthon BS, Wood LG, 'The Effects of Prebiotics, Synbiotics, and Short-Chain Fatty Acids on Respiratory Tract Infections and Immune Function: A Systematic Review and Meta-Analysis.', Adv Nutr, 13 167-192 (2022) [C1]
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Nova |
2022 |
Williams EJ, Guilleminault L, Berthon BS, Eslick S, Wright T, Karihaloo C, et al., 'Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages.', J Nutr Biochem, 104 108978 (2022) [C1]
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Nova |
2022 |
Hosseini B, Berthon BS, Jensen ME, McLoughlin RF, Wark PAB, Nichol K, et al., 'The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses', Nutrients, 14 3087-3087 (2022) [C1]
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Nova |
2022 |
Berthon BS, Williams LM, Williams EJ, Wood LG, 'Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.', Advances in nutrition (Bethesda, Md.), 13 1799-1819 (2022) [C1]
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Nova |
2021 |
Thompson CA, Eslick SR, Berthon BS, Wood LG, 'Asthma medication use in obese and healthy weight asthma: systematic review/meta-analysis.', The European respiratory journal, 57 2000612 (2021) [C1]
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Nova |
2021 |
Berthon BS, McLoughlin RF, Jensen ME, Hosseini B, Williams EJ, Baines KJ, et al., 'The effects of increasing fruit and vegetable intake in children with asthma: A randomized controlled trial', CLINICAL AND EXPERIMENTAL ALLERGY, 51 1144-1156 (2021) [C1]
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Nova |
2021 |
Hosseini B, Berthon BS, Starkey MR, Collison A, McLoughlin RF, Williams EJ, et al., 'Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls', FRONTIERS IN IMMUNOLOGY, 12 (2021) [C1]
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Nova |
2021 |
McLoughlin RF, Berthon BS, Wood LG, 'Weight loss in obese children with asthma-is it important?', PAEDIATRIC RESPIRATORY REVIEWS, 37 10-14 (2021) [C1]
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Nova |
2019 |
Stoodley I, Garg M, Scott H, Macdonald-Wicks L, Berthon B, Wood L, 'Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study.', Nutrients, 12 (2019) [C1]
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Nova |
2019 |
Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, et al., 'Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143 305-315 (2019) [C1]
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Nova |
2019 |
McLoughlin R, Berthon BS, Rogers GB, Baines KJ, Leong LEX, Gibson PG, et al., 'Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial', EBioMedicine, 46 473-485 (2019) [C1]
Background: Soluble fibre modulates airway inflammation in animal models. The aim of this study was to investigate the effects of soluble fibre supplementation, with and without a... [more]
Background: Soluble fibre modulates airway inflammation in animal models. The aim of this study was to investigate the effects of soluble fibre supplementation, with and without a probiotic, on plasma short chain fatty acids (SCFA), airway inflammation, asthma control and gut microbiome in adults with asthma. Methods: A randomised, double-blinded, placebo controlled 3-way cross-over trial in 17 subjects with stable asthma at the Hunter Medical Research Institute, Newcastle, Australia. Subjects received 3 × 7 day oral interventions in random order; soluble fibre (inulin 12 g/day), soluble fibre + probiotic (inulin 12 g/day + multi-strain probiotic >25 billion CFU) and placebo. Plasma SCFA, sputum cell counts and inflammatory gene expression, asthma control gut microbiota, adverse events including gastrointestinal symptoms were measured. Findings: There was no difference in change in total plasma SCFA levels (µmol/L) in the placebo versus soluble fibre (¿median [95% CI] 16·3 [-16·9, 49·5], p = 0·335) or soluble fibre+probiotic (18·7 [-14·5, 51·9], p = 0·325) group. Following the soluble fibre intervention there was an improvement in the asthma control questionnaire (ACQ6) (¿median (IQR) -0·35 (-0·5, -0·13), p = 0·006), sputum %eosinophils decreased (-1.0 (-2·5, 0), p = 0·006) and sputum histone deacetylase 9 (HDAC9) gene expression decreased (-0.49 (-0.83, -0.27) 2-¿Ct, p =.008). Individual bacterial operational taxonomic units changed following both inulin and inulin+probiotic arms. Interpretation: Soluble fibre supplementation for 7 days in adults with asthma did not change SCFA levels. Within group analysis showed improvements in airway inflammation, asthma control and gut microbiome composition following inulin supplementation and these changes warrant further investigation, in order to evaluate the potential of soluble fibre as a non-pharmacological addition to asthma management. Fund: John Hunter Hospital Charitable Trust.
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Nova |
2018 |
Hosseini B, Berthon BS, Saedisomeolia A, Starkey MR, Collison A, Wark PAB, Wood LG, 'Effects of fruit and vegetable consumption on inflammatory biomarkers and immune cell populations: a systematic literature review and meta-analysis.', The American journal of clinical nutrition, 108 136-155 (2018) [C1]
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Nova |
2017 |
McLoughlin RF, Berthon BS, Jensen ME, Baines KJ, Wood LG, 'Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: A systematic review and meta-analysis', American Journal of Clinical Nutrition, 106 930-945 (2017) [C1]
Background: Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflamm... [more]
Background: Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflammatory effects. Objective: This review examines the effect of SCFAs, prebiotics, and pre- and probiotic combinations (synbiotics) on systemic inflammation. Design: Relevant English language studies from 1947 to May 2017 were identified with the use of online databases. Studies were considered eligible if they examined the effects of SCFAs, prebiotics, or synbiotics; were delivered orally, intravenously, or per rectum; were on biomarkers of systemic inflammation in humans; and performed meta-analysis where possible. Results: Sixty-eight studies were included. Fourteen of 29 prebiotic studies and 13 of 26 synbiotic studies reported a significant decrease in =1 marker of systemic inflammation. Eight studies compared prebiotic and synbiotic supplementation, 2 of which reported a decrease in inflammation with synbiotics only, with 1 reporting a greater anti-inflammatory effect with synbiotics than with prebiotics alone. Meta-analyses indicated that prebiotics reduce C-reactive protein (CRP) [standardized mean difference (SMD): -0.60; 95% CI: -0.98, -0.23], and synbiotics reduce CRP (SMD: -0.40; 95% CI: -0.73, -0.06) and tumor necrosis factor-a (SMD -0.90; 95% CI: -1.50, -0.30). Conclusions: There is significant heterogeneity of outcomes in studies examining the effect of prebiotics and synbiotics on systemic inflammation. Approximately 50% of included studies reported a decrease in =1 inflammatory biomarker. The inconsistency in reported outcomes may be due to heterogeneity in study design, supplement formulation, dosage, duration, and subject population. Nonetheless, meta-analyses provide evidence to support the systemic anti-inflammatory effects of prebiotic and synbiotic supplementation.
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Nova |
2017 |
Halnes I, Baines KJ, Berthon BS, MacDonald-Wicks LK, Gibson PG, Wood LG, 'Soluble fibre meal challenge reduces airway inflammation and expression of GPR43 and GPR41 in asthma', Nutrients, 9 1-11 (2017) [C1]
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Nova |
2017 |
Williams EJ, Baines KJ, Berthon BS, Wood LG, 'Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial', NUTRIENTS, 9 (2017) [C1]
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Nova |
2017 |
Hosseini B, Berthon BS, Wark P, Wood LG, 'Effects of Fruit and Vegetable Consumption on Risk of Asthma, Wheezing and Immune Responses: A Systematic Review and Meta-Analysis', NUTRIENTS, 9 (2017) [C1]
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Nova |
2017 |
Berthon BS, Gibson PG, Wood LG, MacDonald-Wicks LK, Baines KJ, 'A sputum gene expression signature predicts oral corticosteroid response in asthma', EUROPEAN RESPIRATORY JOURNAL, 49 (2017) [C1]
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Nova |
2017 |
Guilleminault L, Williams EJ, Scott HA, Berthon BS, Jensen M, Wood LG, 'Diet and Asthma: Is It Time to Adapt Our Message?', Nutrients, 9 (2017) [C1]
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Nova |
2015 |
Berthon BS, Gibson PG, Mcelduff P, Macdonald-Wicks LK, Wood LG, 'Effects of short-term oral corticosteroid intake on dietary intake, body weight and body composition in adults with asthma - a randomized controlled trial', Clinical and Experimental Allergy, 45 908-919 (2015) [C1]
Background: Oral corticosteroids (OCS) are an efficacious treatment for asthma exacerbations, yet risk of adverse effects may decrease patient adherence to therapy. In particular,... [more]
Background: Oral corticosteroids (OCS) are an efficacious treatment for asthma exacerbations, yet risk of adverse effects may decrease patient adherence to therapy. In particular, changes in appetite and dietary intake, which lead to weight gain and changes in body composition, are considered undesirable. Objective: To determine whether 10-day OCS therapy in adults with asthma causes changes in leptin, appetite, dietary intake, body weight and body composition. Methods: Double-blinded, placebo-controlled randomized cross-over trial of 10 days prednisolone (50 mg) in adults with stable asthma (n = 55) (ACTRN12611000562976). Pre- and post-assessment included spirometry, body weight, body composition measured by dual-energy X-ray absorptiometry and bioelectrical impedance analysis, appetite measured using a validated visual analogue scale (VAS) and dietary intake assessed using 4-day food records. Leptin was measured as a biomarker of appetite and eosinophils as an adherence biomarker. Outcomes were analysed by generalized linear mixed models. Results: Subject adherence was confirmed by a significant decrease in blood eosinophils (× 109/L) following prednisolone compared to placebo [Coef. -0.29, 95% CI: (-0.39, -0.19) P < 0.001]. There was no difference in serum leptin (ng/mL) [Coef. 0.13, 95% CI: (-3.47, 3.72) P = 0.945] or appetite measured by VAS (mm) [Coef. -4.93, 95% CI: (-13.64, 3.79) P = 0.267] following prednisolone vs. placebo. There was no difference in dietary intake (kJ/day) [Coef. 255, 95% CI: (-380, 891) P = 0.431], body weight (kg) [Coef. -0.38, 95% CI: (-0.81, 0.05) P = 0.083] or body fat (%) [Coef. -0.31, 95% CI: (-0.81, 0.20) P = 0.230]. Symptoms including sleep and gastrointestinal disturbance were reported significantly more often during prednisolone vs. placebo. Conclusions and Clinical Relevance: Short-term OCS in stable asthma did not induce significant changes in appetite, dietary intake, body weight or composition, although other adverse effects may require medical management. This evidence may assist in increasing medication adherence of asthmatics prescribed OCS for exacerbations.
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Nova |
2015 |
Berthon BS, Wood LG, 'Nutrition and Respiratory Health-Feature Review', NUTRIENTS, 7 1618-1643 (2015) [C1]
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Nova |
2015 |
Wood LG, Shivappa N, Berthon BS, Gibson PG, Hebert JR, 'Dietary inflammatory index is related to asthma risk, lung function and systemic inflammation in asthma', Clinical and Experimental Allergy, 45 177-183 (2015) [C1]
Background: Asthma prevalence has increased in recent years, and evidence suggests that diet may be a contributing factor. Increased use of processed foods has led to a decrease i... [more]
Background: Asthma prevalence has increased in recent years, and evidence suggests that diet may be a contributing factor. Increased use of processed foods has led to a decrease in diet quality, which may be creating a pro-inflammatory environment, thereby leading to the development and/or progression of various chronic inflammatory diseases and conditions. Recently, the dietary inflammatory index (DII) has been developed and validated to assess the inflammatory potential of individual diets. Objective: This study aimed to examine the DII in subjects with asthma compared to healthy controls and to relate the DII to asthma risk, lung function and systemic inflammation. Methods: Subjects with asthma (n = 99) and healthy controls (n = 61) were recruited. Blood was collected and spirometry was performed. The DII was calculated from food frequency questionnaires administered to study subjects. Results: The mean DII score for the asthmatics was higher than the mean DII score for healthy controls (- 1.40 vs. - 1.86, P = 0.04), indicating that their diets were more pro-inflammatory. For every 1 unit increase in DII score, the odds of having asthma increased by 70% (OR: 1.70, 95% CI: 1.03, 2.14; P = 0.040). FEV1 was significantly associated with DII score (ß = - 3.44, 95% CI: - 6.50, - 0.39; P = 0.020), indicating that for every 1 unit increase in DII score, FEV1 decreased by 3.44 times. Furthermore, plasma IL-6 concentrations were positively associated with DII score (ß = 0.13, 95% CI: 0.05, 0.21; P = 0.002). Conclusion and Clinical Relevance: As assessed using the DII score, the usual diet consumed by asthmatics in this study was pro-inflammatory relative to the diet consumed by the healthy controls. The DII score was associated with increased systemic inflammation and lower lung function. Hence, consumption of pro-inflammatory foods may contribute to worse asthma status, and targeting an improvement in DII in asthmatics, as an indicator of suitable dietary intake, might be a useful strategy for improving clinical outcomes in the disease.
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Nova |
2015 |
Berthon B, wood LG, 'Oral Corticosteroid Use in Exacerbations of Asthma', Clinical Immunology, Endocrine & Metabolic Drugs, 2 2-3 (2015) [C3]
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Nova |
2015 |
Wood LG, Lagleva M, Shah S, Berthon BS, Galbraith S, Henry R, et al., 'Dietary changes in migrant adolescents with increasing length of stay in Australia and associated risk of wheeze - a retrospective, cross sectional study', BMC Pediatrics, 15 (2015) [C1]
Background: Recent studies have reported that asthma prevalence increases on migration to Australia. We hypothesised that changes in dietary intake contribute to this phenomenon. ... [more]
Background: Recent studies have reported that asthma prevalence increases on migration to Australia. We hypothesised that changes in dietary intake contribute to this phenomenon. The aim of this study was to assess dietary intake in relation to migration status, length of stay in Australia and the association with self-reported wheeze. Methods: Students (n = 144) in a multicultural high school in Western Sydney completed the asthma symptoms ISAAC video questionnaire (AVQ3.0), spirometry and allergy skin prick tests. A dietitian administered a'Food Frequency' and 'Food Habits' questionnaire and a dietary history interview. Results: Students who spoke a language other than English, consumed a traditional or mixed dietary pattern, with lower consumption of saturated fat, compared to students who spoke English only. Saturated fat intake increased and fibre intake decreased with length of time in Australia. Intake of foods high in saturated or trans fatty acids were positively associated with length of stay in Australia. No associations between nutrient intake or whole food intake and self-reported wheeze were observed. Conclusion: As time progressed, dietary intake of immigrant children changed. While this was not associated with the development of wheeze in the students in this cohort, these changes are likely to have negative health consequences.
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Nova |
2014 |
Berthon BS, MacDonald-Wicks LK, Wood LG, 'A systematic review of the effect of oral glucocorticoids on energy intake, appetite, and body weight in humans', NUTRITION RESEARCH, 34 179-190 (2014) [C1]
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Nova |
2013 |
Berthon BS, Macdonald-Wicks LK, Gibson PG, Wood LG, 'Investigation of the association between dietary intake, disease severity and airway inflammation in asthma', RESPIROLOGY, 18 447-454 (2013) [C1]
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Nova |
2012 |
Burrows TL, Berthon B, Garg ML, Collins CE, 'A comparative validation of a child food frequency questionnaire using red blood cell membrane fatty acids', European Journal of Clinical Nutrition, 66 825-829 (2012) [C1]
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Nova |
2012 |
Morgan PJ, Collins CE, Plotnikoff RC, Cook AT, Berthon B, Mitchell S, Callister R, 'The impact of a workplace-based weight loss program on work-related outcomes in overweight male shift workers', Journal of Occupational and Environmental Medicine, 54 122-127 (2012) [C1]
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Nova |
2011 |
Morgan PJ, Collins CE, Plotnikoff RC, Cook AT, Berthon B, Mitchell S, Callister R, 'Efficacy of a workplace-based weight loss program for overweight male shift workers: The Workplace POWER (Preventing Obesity Without Eating like a Rabbit) randomized controlled trial', Preventive Medicine, 52 317-325 (2011) [C1]
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Nova |