Dr Rebecca McLoughlin

Dr Rebecca McLoughlin

Postdoctoral Researcher

School of Nursing and Midwifery

Career Summary

Biography

Dr. Rebecca McLoughlin is an Accredited Practicing Dietitian and a Postdoctoral Researcher with the School of Nursing and Midwifery, College of Health, Medicine and Wellbeing, University of Newcastle. Rebecca has 6 years of doctoral and postdoctoral experience in undertaking clinical research studies. Her recent work focuses on the development of innovative approaches for the management of obstructive airway diseases, such as severe asthma.

Rebecca holds a Bachelor of Nutrition and Dietetics (Hons 1, University Medal) from the University of Newcastle, and in 2019 was awarded a PhD (Nutritional Biochemistry) at the University of Newcastle for her work examining the impact of nutritional on inflammation, and ultimately, the effect this has on the pathogenesis of asthma. 

A primary research goal of Dr. McLoughlin's is to conduct high quality research that is directly translatable into clinical practice, to improve the management of people with obstructive airway diseases.


Qualifications

  • Doctor of Philosophy in Nutritional Biochemistry, University of Newcastle
  • Bachelor of Nutrition and Dietetics (HonsClass1) Uni Medal, University of Newcastle

Keywords

  • asthma
  • nutrition
  • obstructive airway disease
  • respiratory

Fields of Research

Code Description Percentage
321001 Clinical nutrition 40
320103 Respiratory diseases 60

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Researcher University of Newcastle
School of Nursing and Midwifery
Australia

Professional appointment

Dates Title Organisation / Department
7/3/2019 - 16/10/2020 Postdoctoral Clinical Researcher The University of Newcastle - School of Biomedical Sciences and Pharmacy
Faculty of Health
Australia

Awards

Award

Year Award
2017 Best Oral Presentation of the Annual Scientific Meeting of the Nutrition Society of Australia in conjunction with the APCCN
Nutrition Society Australia
2017 Travel Grant for the 10th Asia Pacific Conference on Clinical Nutrition in Adelaide
Nutrition Society Australia
2016 Travel Grant for the Nutrition Society of Australia Annual Scientific Meeting in Melbourne
Nutrition Society Australia
2015 Travel Grant for the Joint NSA and New Zealand Annual Conference in Wellington
Nutrition Society Australia
2014 University of Newcastle, Faculty of Health and Medicine's (FHEAM) Scholar award
College of Health, Medicine and Wellbeing, University of Newcastle
2013 University of Newcastle, Faculty of Health and Medicine's (FHEAM) Scholar award
College of Health, Medicine and Wellbeing, University of Newcastle

Distinction

Year Award
2015 University Medal
School of Health Science, Faculty of Health & Medicine, The University of Newcastle

Scholarship

Year Award
2015 Australian Postgraduate Award
Faculty of Health and Medicine, The University of Newcastle
2014 School of Health Sciences Vacation Scholarship
School of Health Science, Faculty of Health & Medicine, The University of Newcastle
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2019 McLoughlin R, Berthon B, Williams E, Wood L, 'Vitamin E and air pollution', Vitamin E in Human Health, Springer, Switzerland 385-403 (2019)
Co-authors Bronwyn Berthon, Lisa Wood

Journal article (6 outputs)

Year Citation Altmetrics Link
2021 Berthon BS, McLoughlin RF, Jensen ME, Hosseini B, Williams EJ, Baines KJ, et al., 'The effects of increasing fruit and vegetable intake in children with asthma: A randomized controlled trial.', Clin Exp Allergy, 51 1144-1156 (2021)
DOI 10.1111/cea.13979
Citations Scopus - 1Web of Science - 1
Co-authors Joerg Mattes, Adam Collison, Lisa Wood, Bronwyn Berthon, Megan Jensen, Katherine Baines, Malcolm Starkey, Peter Wark
2021 Hosseini B, Berthon BS, Starkey MR, Collison A, McLoughlin RF, Williams EJ, et al., 'Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls.', Front Immunol, 12 664668 (2021)
DOI 10.3389/fimmu.2021.664668
Co-authors Lisa Wood, Adam Collison, Megan Jensen, Katherine Baines, Peter Wark, Joerg Mattes, Bronwyn Berthon, Malcolm Starkey
2021 McLoughlin RF, Berthon BS, Wood LG, 'Weight loss in obese children with asthma-is it important?', PAEDIATRIC RESPIRATORY REVIEWS, 37 10-14 (2021) [C1]
DOI 10.1016/j.prrv.2020.02.007
Citations Scopus - 2Web of Science - 1
Co-authors Lisa Wood, Bronwyn Berthon
2019 McLoughlin R, Berthon BS, Rogers GB, Baines KJ, Leong LEX, Gibson PG, et al., 'Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial', EBioMedicine, 46 473-485 (2019) [C1]

Background: Soluble fibre modulates airway inflammation in animal models. The aim of this study was to investigate the effects of soluble fibre supplementation, with and without a... [more]

Background: Soluble fibre modulates airway inflammation in animal models. The aim of this study was to investigate the effects of soluble fibre supplementation, with and without a probiotic, on plasma short chain fatty acids (SCFA), airway inflammation, asthma control and gut microbiome in adults with asthma. Methods: A randomised, double-blinded, placebo controlled 3-way cross-over trial in 17 subjects with stable asthma at the Hunter Medical Research Institute, Newcastle, Australia. Subjects received 3 × 7 day oral interventions in random order; soluble fibre (inulin 12 g/day), soluble fibre + probiotic (inulin 12 g/day + multi-strain probiotic >25 billion CFU) and placebo. Plasma SCFA, sputum cell counts and inflammatory gene expression, asthma control gut microbiota, adverse events including gastrointestinal symptoms were measured. Findings: There was no difference in change in total plasma SCFA levels (µmol/L) in the placebo versus soluble fibre (¿median [95% CI] 16·3 [-16·9, 49·5], p = 0·335) or soluble fibre+probiotic (18·7 [-14·5, 51·9], p = 0·325) group. Following the soluble fibre intervention there was an improvement in the asthma control questionnaire (ACQ6) (¿median (IQR) -0·35 (-0·5, -0·13), p = 0·006), sputum %eosinophils decreased (-1.0 (-2·5, 0), p = 0·006) and sputum histone deacetylase 9 (HDAC9) gene expression decreased (-0.49 (-0.83, -0.27) 2-¿Ct, p =.008). Individual bacterial operational taxonomic units changed following both inulin and inulin+probiotic arms. Interpretation: Soluble fibre supplementation for 7 days in adults with asthma did not change SCFA levels. Within group analysis showed improvements in airway inflammation, asthma control and gut microbiome composition following inulin supplementation and these changes warrant further investigation, in order to evaluate the potential of soluble fibre as a non-pharmacological addition to asthma management. Fund: John Hunter Hospital Charitable Trust.

DOI 10.1016/j.ebiom.2019.07.048
Citations Scopus - 21Web of Science - 18
Co-authors Lisa Wood, Katherine Baines, Bronwyn Berthon, Peter Gibson
2017 McLoughlin RF, Berthon BS, Jensen ME, Baines KJ, Wood LG, 'Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: A systematic review and meta-analysis', American Journal of Clinical Nutrition, 106 930-945 (2017) [C1]

Background: Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflamm... [more]

Background: Prebiotic soluble fibers are fermented by beneficial bacteria in the colon to produce short-chain fatty acids (SCFAs), which are proposed to have systemic anti-inflammatory effects. Objective: This review examines the effect of SCFAs, prebiotics, and pre- and probiotic combinations (synbiotics) on systemic inflammation. Design: Relevant English language studies from 1947 to May 2017 were identified with the use of online databases. Studies were considered eligible if they examined the effects of SCFAs, prebiotics, or synbiotics; were delivered orally, intravenously, or per rectum; were on biomarkers of systemic inflammation in humans; and performed meta-analysis where possible. Results: Sixty-eight studies were included. Fourteen of 29 prebiotic studies and 13 of 26 synbiotic studies reported a significant decrease in =1 marker of systemic inflammation. Eight studies compared prebiotic and synbiotic supplementation, 2 of which reported a decrease in inflammation with synbiotics only, with 1 reporting a greater anti-inflammatory effect with synbiotics than with prebiotics alone. Meta-analyses indicated that prebiotics reduce C-reactive protein (CRP) [standardized mean difference (SMD): -0.60; 95% CI: -0.98, -0.23], and synbiotics reduce CRP (SMD: -0.40; 95% CI: -0.73, -0.06) and tumor necrosis factor-a (SMD -0.90; 95% CI: -1.50, -0.30). Conclusions: There is significant heterogeneity of outcomes in studies examining the effect of prebiotics and synbiotics on systemic inflammation. Approximately 50% of included studies reported a decrease in =1 inflammatory biomarker. The inconsistency in reported outcomes may be due to heterogeneity in study design, supplement formulation, dosage, duration, and subject population. Nonetheless, meta-analyses provide evidence to support the systemic anti-inflammatory effects of prebiotic and synbiotic supplementation.

DOI 10.3945/ajcn.117.156265
Citations Scopus - 90Web of Science - 86
Co-authors Lisa Wood, Megan Jensen, Bronwyn Berthon, Katherine Baines
2017 McLoughlin RF, McDonald VM, Gibson PG, Scott HA, Hensley MJ, MacDonald-Wicks L, Wood LG, 'The Impact of a Weight Loss Intervention on Diet Quality and Eating Behaviours in People with Obesity and COPD.', Nutrients, 9 1-14 (2017) [C1]
DOI 10.3390/nu9101147
Citations Scopus - 4Web of Science - 4
Co-authors Hayley Scott, Peter Gibson, Vanessa Mcdonald, Lisa Wood, Michael Hensley, Lesley Wicks
Show 3 more journal articles

Conference (2 outputs)

Year Citation Altmetrics Link
2020 Wood LG, Berthon BS, McLoughlin RL, Jensen ME, Hosseini B, Williams EJ, et al., 'A Fruit and Vegetable Intervention in Children with Asthma Improved Lung Function and Decreased Asthma Related Illness', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ELECTR NETWORK (2020)
Co-authors Adam Collison, Peter Wark, Katherine Baines, Megan Jensen, Lisa Wood, Joerg Mattes, Malcolm Starkey, Bronwyn Berthon
2018 McLoughlin R, Berthon BS, Baines KJ, Gibson PG, Rogers GB, Arnold D, Wood LG, 'Soluble Fibre Downregulates Airway Histone Deacetylase 9 Expression Which Is Associated with Eosinophilic Inflammation in Asthma', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, San Diego, CA (2018)
Co-authors Peter Gibson, Lisa Wood, Katherine Baines, Bronwyn Berthon
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Grants and Funding

Summary

Number of grants 4
Total funding $57,182

Click on a grant title below to expand the full details for that specific grant.


20213 grants / $48,182

HMRI RSP Seed Funding Grant $25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Rebecca McLoughlin, Doctor Vanessa Clark
Scheme Research Grant
Role Investigator
Funding Start 2021
Funding Finish 2021
GNo G2001470
Type Of Funding C3300 – Aust Philanthropy
Category 3300
UON Y

Personalised medicine for severe asthma: treatable traits$18,182

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Doctor Rebecca McLoughlin, Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Vanessa Clark
Scheme John Hunter Hospital Charitable Trust Grant
Role Lead
Funding Start 2021
Funding Finish 2021
GNo G2100272
Type Of Funding C2400 – Aust StateTerritoryLocal – Other
Category 2400
UON Y

Understanding Breathlessness in Asthma$5,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Vanessa Clark, Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Sarah Hiles, Conjoint Associate Professor Anne Vertigan, Doctor Rebecca McLoughlin
Scheme Research Grant
Role Investigator
Funding Start 2021
Funding Finish 2021
GNo G2100080
Type Of Funding C3300 – Aust Philanthropy
Category 3300
UON Y

20201 grants / $9,000

Investigating inflammatory pathways in children with asthma$9,000

Funding body: PRC GrowUpWell

Funding body PRC GrowUpWell
Project Team

Prof. Lisa Wood, Dr. Rebecca McLoughlin

Scheme Seed Funding
Role Investigator
Funding Start 2020
Funding Finish 2020
GNo
Type Of Funding Internal
Category INTE
UON N
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Dr Rebecca McLoughlin

Position

Postdoctoral Researcher
School of Nursing and Midwifery
College of Health, Medicine and Wellbeing

Contact Details

Email bec.mcloughlin@newcastle.edu.au
Phone (02) 40420011

Office

Room HMRI level 2 west
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