2023 |
Williams LM, Berthon BS, Stoodley IL, Williams EJ, Wood LG, 'Medicinal Mushroom Extracts from Hericium coralloides and Trametes versicolor Exert Differential Immunomodulatory Effects on Immune Cells from Older Adults In Vitro', Nutrients, 15 2227-2227 [C1]
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Nova |
2022 |
Eslick S, Williams EJ, Berthon BS, Wright T, Karihaloo C, Gately M, Wood LG, 'Weight Loss and Short-Chain Fatty Acids Reduce Systemic Inflammation in Monocytes and Adipose Tissue Macrophages from Obese Subjects', Nutrients, 14 (2022) [C1]
Background: Chronic low-grade systemic inflammation is a characteristic of obesity that leads to various non-communicable diseases. Weight loss and SCFAs are potential strategies ... [more]
Background: Chronic low-grade systemic inflammation is a characteristic of obesity that leads to various non-communicable diseases. Weight loss and SCFAs are potential strategies for attenuating obese systemic inflammation. Methods: Blood samples were collected from 43 obese subjects (BMI = 30 kg/m2) scheduled for laparoscopic bariatric sleeve surgery, 26 obese subjects at follow-up 12¿18 months post-surgery and 8 healthy weight subjects (BMI 18.5¿24.9 kg/m2). Mono-cytes were isolated from blood and adipose tissue macrophages from visceral adipose tissue of obese subjects only. Isolated cells stimulated with 1 ng/mL LPS and treated simultaneously with 300 mM of sodium acetate or 30 mM of sodium propionate or butyrate and supernatant were har-vested after 15 h incubation. TNF-a and IL-6 cytokines were measured via ELISA and mRNA gene expression of FFAR2 and FFAR3, HDAC1, HDAC2 and HDAC9, RELA and NFKB1 and MAPK1 via RT-qPCR. Results: TNF-a and IL-6 production and NFKB1 and RELA mRNA expression were significantly decreased in follow-up subjects compared to baseline. SCFAs significantly reduced TNF-a and IL-6 and altered FFAR and HDAC mRNA expression in monocytes and macrophages from obese subjects. Conclusion: Weight loss and ex vivo SCFA treatments were successful in combatting systemic inflammation in obesity. Results highlighted molecular changes that occur with weight loss and as a result of SCFA treatment.
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Nova |
2022 |
Williams EJ, Berthon BS, Stoodley I, Williams LM, Wood LG, 'Nutrition in Asthma', SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 43 646-661 (2022) [C1]
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Nova |
2022 |
Williams EJ, Guilleminault L, Berthon BS, Eslick S, Wright T, Karihaloo C, et al., 'Sulforaphane reduces pro-inflammatory response to palmitic acid in monocytes and adipose tissue macrophages.', J Nutr Biochem, 104 108978 (2022) [C1]
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Nova |
2022 |
Hosseini B, Berthon BS, Jensen ME, McLoughlin RF, Wark PAB, Nichol K, et al., 'The Effects of Increasing Fruit and Vegetable Intake in Children with Asthma on the Modulation of Innate Immune Responses', Nutrients, 14 3087-3087 (2022) [C1]
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Nova |
2022 |
Thompson D, Wood LG, Williams EJ, McLoughlin RF, Rastogi D, 'Endotyping pediatric obesity-related asthma: Contribution of anthropometrics, metabolism, nutrients, and CD4
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Nova |
2022 |
Berthon BS, Williams LM, Williams EJ, Wood LG, 'Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis.', Advances in nutrition (Bethesda, Md.), 13 1799-1819 (2022) [C1]
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Nova |
2022 |
Scott HA, Wood LG, Williams EJ, Weaver N, Upham JW, 'Comparing the Effect of Acute Moderate and Vigorous Exercise on Inflammation in Adults with Asthma: A Randomized Controlled Trial.', Annals of the American Thoracic Society, 19 1848-1855 (2022) [C1]
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Nova |
2021 |
Berthon BS, McLoughlin RF, Jensen ME, Hosseini B, Williams EJ, Baines KJ, et al., 'The effects of increasing fruit and vegetable intake in children with asthma: A randomized controlled trial', CLINICAL AND EXPERIMENTAL ALLERGY, 51 1144-1156 (2021) [C1]
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Nova |
2021 |
Hosseini B, Berthon BS, Starkey MR, Collison A, McLoughlin RF, Williams EJ, et al., 'Children With Asthma Have Impaired Innate Immunity and Increased Numbers of Type 2 Innate Lymphoid Cells Compared With Healthy Controls', FRONTIERS IN IMMUNOLOGY, 12 (2021) [C1]
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Nova |
2021 |
'Abstracts', Respirology, 26 123-207 (2021)
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2021 |
Williams EJ, Negewo NA, Baines KJ, 'Role of the NLRP3 inflammasome in asthma: Relationship with neutrophilic inflammation, obesity, and therapeutic options', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147 2060-2062 (2021)
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2019 |
Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, et al., 'Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143 305-315 (2019) [C1]
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Nova |
2019 |
McLoughlin R, Berthon BS, Rogers GB, Baines KJ, Leong LEX, Gibson PG, et al., 'Soluble fibre supplementation with and without a probiotic in adults with asthma: A 7-day randomised, double blind, three way cross-over trial', EBioMedicine, 46 473-485 (2019) [C1]
Background: Soluble fibre modulates airway inflammation in animal models. The aim of this study was to investigate the effects of soluble fibre supplementation, with and without a... [more]
Background: Soluble fibre modulates airway inflammation in animal models. The aim of this study was to investigate the effects of soluble fibre supplementation, with and without a probiotic, on plasma short chain fatty acids (SCFA), airway inflammation, asthma control and gut microbiome in adults with asthma. Methods: A randomised, double-blinded, placebo controlled 3-way cross-over trial in 17 subjects with stable asthma at the Hunter Medical Research Institute, Newcastle, Australia. Subjects received 3 × 7 day oral interventions in random order; soluble fibre (inulin 12 g/day), soluble fibre + probiotic (inulin 12 g/day + multi-strain probiotic >25 billion CFU) and placebo. Plasma SCFA, sputum cell counts and inflammatory gene expression, asthma control gut microbiota, adverse events including gastrointestinal symptoms were measured. Findings: There was no difference in change in total plasma SCFA levels (µmol/L) in the placebo versus soluble fibre (¿median [95% CI] 16·3 [-16·9, 49·5], p = 0·335) or soluble fibre+probiotic (18·7 [-14·5, 51·9], p = 0·325) group. Following the soluble fibre intervention there was an improvement in the asthma control questionnaire (ACQ6) (¿median (IQR) -0·35 (-0·5, -0·13), p = 0·006), sputum %eosinophils decreased (-1.0 (-2·5, 0), p = 0·006) and sputum histone deacetylase 9 (HDAC9) gene expression decreased (-0.49 (-0.83, -0.27) 2-¿Ct, p =.008). Individual bacterial operational taxonomic units changed following both inulin and inulin+probiotic arms. Interpretation: Soluble fibre supplementation for 7 days in adults with asthma did not change SCFA levels. Within group analysis showed improvements in airway inflammation, asthma control and gut microbiome composition following inulin supplementation and these changes warrant further investigation, in order to evaluate the potential of soluble fibre as a non-pharmacological addition to asthma management. Fund: John Hunter Hospital Charitable Trust.
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Nova |
2017 |
Williams EJ, Baines KJ, Berthon BS, Wood LG, 'Effects of an Encapsulated Fruit and Vegetable Juice Concentrate on Obesity-Induced Systemic Inflammation: A Randomised Controlled Trial', NUTRIENTS, 9 (2017) [C1]
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Nova |
2017 |
Guilleminault L, Williams EJ, Scott HA, Berthon BS, Jensen M, Wood LG, 'Diet and Asthma: Is It Time to Adapt Our Message?', Nutrients, 9 (2017) [C1]
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Nova |
2016 |
Williams EJ, Baines KJ, Smart JM, Gibson PG, Wood LG, 'Rosuvastatin, lycopene and omega-3 fatty acids: A potential treatment for systemic inflammation in COPD; a pilot study', Journal of Nutrition and Intermediary Metabolism, 5 86-95 (2016) [C1]
Background/Aims Chronic Obstructive Pulmonary Disease (COPD) is characterized by airway inflammation, in which contributes to loss of lung function. Systemic inflammation is also ... [more]
Background/Aims Chronic Obstructive Pulmonary Disease (COPD) is characterized by airway inflammation, in which contributes to loss of lung function. Systemic inflammation is also a feature of COPD contributing to many associated co-morbidities. Statins, omega-3 fatty acids (docosahexanoic acid, DHA and eicosapentanoic acid, EPA) and lycopene have been shown to decrease systemic inflammation; however their combined effects have not been investigated. This study aims to identify changes in systemic and airway inflammation induced by statins alone or in combination with DHA, EPA and lycopene in COPD. Methods COPD patients (n¿=¿11) received rosuvastatin (20¿mg/day) for 4 weeks, then a combination of rosuvastatin (20¿mg/day), DHA and EPA (1.5¿g/day) and lycopene (45¿mg/day) for 8 weeks. Blood and sputum were collected and lung function measured by spirometry at baseline, week 4 and 12. Plasma fatty acids were measured using gas chromatography, while plasma carotenoids were analysed using high-performance liquid chromatography. Plasma CRP and IL-6 concentrations were measured using ELISA; and peripheral blood gene expression was measured using the nCounter¿ GX Human Inflammation Kit 2. Results Following the interventions, clinical characteristics and plasma IL-6 and CRP were unchanged. Sputum neutrophil proportion and absolute count was increased and macrophage proportion decreased by rosuvastatin (P¿=¿0.020 and P¿=¿0.015; respectively). Rosuvastatin increased LTB4R and decreased CXCL10 and AGER gene expression in white blood cells. The addition of lycopene and omega-3 fatty acids decreased LTB4R and increased CXCL10 to basal levels, whilst combined use of interventions increased ALOX15 blood gene expression. Conclusion This study shows that rosuvastatin, omega-3 fatty acids and lycopene have some anti-inflammatory effects systemically, but rosuvastatin may increase airway neutrophils, which would be undesirable in COPD patients, warranting further investigation.
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Nova |
2015 |
Mate KE, Kerr KP, Pond D, Williams EJ, Marley J, Disler P, et al., 'Impact of Multiple Low-Level Anticholinergic Medications on Anticholinergic Load of Community-Dwelling Elderly With and Without Dementia', Drugs and Aging, 32 159-167 (2015) [C1]
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Nova |
2004 |
Azuma T, Williams EJ, Davie JE, 'Paws plus cause = pause? Memory load and memory blends in homophone recognition', PSYCHONOMIC BULLETIN & REVIEW, 11 723-728 (2004)
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