Conjoint Associate Professor Christopher Grainge

Conjoint Associate Professor

School of Medicine and Public Health

Career Summary

Biography

I completed my undergraduate training at Imperial College, University of London including an intercalated BSc, with a period of research at Washington University, St Louis, USA. Towards the end of my undergraduate training I joined the Royal Navy, completing house officer jobs in Portsmouth and Plymouth followed by military training at Britannia Royal Naval College, Dartmouth. I was then appointed as medical officer to HMS Norfolk on deployment to the Caribbean. On my return I worked as a medical officer at the Institute of Naval Medicine specialising in diving medicine and around this time was awarded the Diploma in the Medical Care of Catastrophes, a qualification in remote and refugee medicine. I then deployed to sea again, this time on HMS Endurance spending a season in Antarctica supporting a scientific programme on the continent.

My Senior House Officer training was at Derriford Hospital in Plymouth, one of the largest district general hospitals in Europe, where I obtained membership of the Royal College of Physicians. I was then deployed to Southern Iraq as one of two physicians in the British military hospital, Shaibah and on my return worked at the Royal Brompton Hospital, London.

My Specialist training in Respiratory, Sleep and General (internal) Medicine started in Wales, then, following a competitive grant award, I moved to the University of Southampton to work with Professor Stephen Holgate’s group. I was awarded my PhD in 2011, the research leading to several International presentations and peer reviewed articles, including a first author paper published in the New England Journal of Medicine examining the effect of repeated bronchoconstriction on the airways in asthma. I also worked with the Defence Science and Technology Laboratories at Porton Down to examine causes and effects of acute lung injury, work which lead to the award of the Gilbert Blane medal by the Presidents of both the Royal College of Physicians and the Royal College of Surgeons.

I was then appointed as a Consultant physician in Respiratory, Sleep and General (Internal) Medicine at the University Hospital, Southampton and Senior Lecturer in Medicine at the University of Southampton. I have received grants from the British Lung Foundation, the Southampton Marine and Maritime Institute, the Institute for Life Sciences and the Gerald Kerkut Foundation to continue research into the effect of physical and environmental stress on lung disease.

I have recently been appointed as a Staff Specialist in Respiratory and General Medicine at the John Hunter Hospital, and a conjoint Associate Professor at the University of Newcastle. I hope to pursue my clinical interests in difficult asthma and interstitial lung disease, and also to continue my research into physical airway stress and fibrotic responses in the airway in collaboration with the team at the HMRI.

Research Expertise
Role of mechanical forces in the pathophysiology of asthma Dr Grainge recently demonstrated that mechanical forces may play an important role in determining long term changes in human airways, that research was published in the New England Journal of Medicine in 2011. Following his move to the University of Newcastle he and his team are investigating how the mechanical forces that are associated with airway narrowing in asthma influence the airway. The role of environmental dusts in pathogenesis of lung disease Recent clinical evidence has suggested that some individuals exposed to high levels of inhaled dusts develop the usually rare lung disease, constrictive bronchiolitis. Following the award of over £220,000 from the British Lung Foundation, the Institute of Life Sciences and the Southampton Marine and Maritime Institution Dr Grainge and his team are investigating the mechanisms underling the development of lung disease including constrictive bronchiolitis following environmental exposure to inhaled particles, and are attempting to identify potential therapies. This project is a collaboration between the National Oceanography Centre and the University of Southampton Faculty of Medicine. The effect of platelet antagonists on allergen challenge in asthma Platelet activation in the lungs occurs following many stimuli including allergen challenge and chemical injury to the lung. Dr Grainge and his group hypothesise that inhibiting platelet activation will decrease the lung injury associated with these stimuli and may provide an additional therapeutic pathway for asthma which has yet to be investigated. The project involves a double blind randomized controlled trial of Clopidogrel, an oral platelet antagonist, and its effects on inhaled allergen challenge.

Teaching Expertise
Teaching Responsibilities Delivers lectures and small group teaching on a variety of general medicine and respiratory medicine topics including respiratory physiology and pathophysiology. Provides clinical teaching on the wards and in clinic to medical students at various points in their undergraduate training. IMPACT. Was one of the first instructors on the Ill Medical Patient Acute Care and Treatment (IMPACT) courses which are run for doctors in their first few years of postgraduate training. Continues to teach and direct the courses at various centers around the country.

Collaborations
I continue to collaborate extensively with the Respiratory Research group at the University of Southampton with work examining the nature and treatment possibilities for severe asthma. In addition I am collaborating with the Asthma and COPD Research Group at the University of Groningen in the Netherlands looking at the mechanical forces within the airway and how these impact on both acute and long term changes in the lungs of patients with airways disease. I am also collaborating with the Microbiome group at the South Australia Medical Research Insitute, examining the differences in the airway microbiome that occur in health and disease.

Keywords

  • allergy
  • asthma
  • bronchoconstriction
  • general medicine
  • interstitial lung disease
  • physiology
  • respiratory

Fields of Research

Code Description Percentage
110203 Respiratory Diseases 100

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/01/2013 -  Editorial Board - Respirology Case Reports Respirology Case Reports
Australia
1/08/2012 - 1/02/2013 Senior Lecturer in Respiratory, Sleep and General Medicine University of Southampton
Faculty of Medicine
United Kingdom
1/10/2007 - 1/09/2010 Research Fellow in Respiratory Medicine University of Southampton
Infection and Inflammation Research Division, Faculty of Medicine
United Kingdom

Professional appointment

Dates Title Organisation / Department
1/08/2012 - 1/02/2013 Consultant Physician in Respiratory, Sleep and General Medicine University Hospital Southampton
Faculty of Medicine
United Kingdom
1/08/2011 - 1/07/2012 Specialist Registrar in Respiratory, Sleep and General Medicine University Hospital, Southampton
Department of Respiratory Medicine
United Kingdom
1/10/2010 - 1/07/2011 Specialist Registrar in Respiratory, Sleep and General Medicine Queen Alexandra Hospital, Portsmouth
Department of Respiratory Medicine
United Kingdom

Awards

Recognition

Year Award
2013 Leatherdale Prize for Clinical Teaching: Finalist
University of Southampton
2011 Military and Civilian Health Partnership Awards. Winner in the
Military and Civilian Health Partnership Awards
2011 University of Southampton Translational Medicine Research Prize
University of Southampton

Research Award

Year Award
2014 Michael Arthur Clinical Research Prize
University of Southampton
2011 British Lung Foundation Travel Fellowship
British Lung Foundation
2010 Gilbert Blane Medal
Royal College of Surgeons and Royal College of Physicians
2010 Colt Foundation Prize: Finalist
Royal Society of Medicine
2009 Asthma UK Travel Fellowship
Asthma UK Travel Fellowship
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (49 outputs)

Year Citation Altmetrics Link
2018 Reid AT, Veerati PC, Gosens R, Bartlett NW, Wark PA, Grainge CL, et al., 'Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches', Pharmacology and Therapeutics, 185 155-169 (2018) [C1]

© 2017 Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To... [more]

© 2017 Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.

DOI 10.1016/j.pharmthera.2017.12.009
Citations Scopus - 1Web of Science - 1
Co-authors Nathan Bartlett, Andrew Reid, Fatemeh Moheimani, Darryl Knight, Philip Hansbro, Peter Wark
2018 Waters DW, Blokland KEC, Pathinayake PS, Burgess JK, Mutsaers SE, Prele CM, et al., 'Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis', American Journal of Physiology - Lung Cellular and Molecular Physiology, 315 L162-L172 (2018) [C1]

© 2018 American Physiological Society. All rights reserved. Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneu monia of unknown cause with a median survi... [more]

© 2018 American Physiological Society. All rights reserved. Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneu monia of unknown cause with a median survival of only three years. Little is known about the mechanisms that precede the excessive collagen deposition seen in IPF, but cellular senescence has been strongly implicated in disease pathology. Senescence is a state of irreversible cell-cycle arrest accompanied by an abnormal secretory profile and is thought to play a critical role in both development and wound repair. Normally, once a senescent cell has contributed to wound repair, it is promptly removed from the environment via infiltrating immune cells. However, if immune clearance fails, the persistence of senescent cells is thought to drive disease pathology through their altered secretory profile. One of the major cell types involved in wound healing is fibroblasts, and senescent fibroblasts have been identified in the lungs of patients with IPF and in fibroblast cultures from IPF lungs. The question of what is driving abnormally high numbers of fibroblasts into senescence remains unanswered. The transcription factor signal transducer and activator of transcription 3 (STAT3) plays a role in a myriad of processes, including cell-cycle progression, gene transcription, as well as mitochondrial respiration, all of which are dysregulated during senescence. Activation of STAT3 has previously been shown to correlate with IPF progression and therefore is a potential molecular target to modify early-stage senescence and restore normal fibroblast function. This review summarizes what is presently known about fibroblast senescence in IPF and how STAT3 may contribute to this phenotype.

DOI 10.1152/ajplung.00037.2018
Citations Scopus - 3Web of Science - 1
Co-authors Darryl Knight, Michael Schuliga
2018 Grainge C, Park J-A, 'Inflammatory insights into airway remodelling in asthma.', Respirology, (2018)
DOI 10.1111/resp.13390
2018 Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD, et al., 'Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations', NATURE COMMUNICATIONS, 9 (2018) [C1]
DOI 10.1038/s41467-018-04574-1
Co-authors Darryl Knight, Nathan Bartlett, Andrew Reid, Peter Wark
2018 Sarwar G, Bisquera A, Peel R, Hancock S, Grainge C, Attia J, 'The effect of inhaled corticosteroids on bone mineral density measured by quantitative ultrasonography in an older population', Clinical Respiratory Journal, 12 659-665 (2018) [C1]

© 2016 John Wiley & Sons Ltd Introduction: Prolonged use of systemic corticosteroids leads to reduced bone mineral density and osteoporosis, in turn increasing the risk of m... [more]

© 2016 John Wiley & Sons Ltd Introduction: Prolonged use of systemic corticosteroids leads to reduced bone mineral density and osteoporosis, in turn increasing the risk of minimal trauma fractures with their associated morbidity and mortality in elderly populations. However, the effect of inhaled corticosteroids on bone mineral density has been debated in the medical literature. Objectives: We aimed to determine the effect of inhaled corticosteroids on bone mineral density measured using calcaneal quantitative ultrasonography in a cohort of older Australians. Methods: Data was collected from the Hunter Community Study, a longitudinal cohort of Australians aged 55-85. Simple and multiple linear regression methods were used to test the cross-sectional association between inhaled corticosteroids and calcaneal bone mineral density measured with quantitative ultrasound at baseline. A causal diagram was used to determine the minimally sufficient number of co-variates necessary to determine the unconfounded effect of inhaled corticosteroids on bone mineral density; these included gender, body mass index, smoking, asthma, alcohol use, age, physical activity, and diet. Results: There were 152 (6.8%) patients on inhaled corticosteroids and 2098 (93%) controls. Simple and multiple linear regression methods showed a non-significant effect of inhaled steroids on BMD with slight decrease of BMD -0.010 g/cm2 (95% CI -0.042 to 0.022, P =.55) and -0.013 g/cm2 (95% CI -0.062 to 0.036, P =.61) respectively. Age, gender, body mass index, and smoking were stronger predictors of BMD. Conclusions: No statistically significant relationship was detected between the use of inhaled corticosteroids and reduced bone mineral density in this observational study of a cohort of older Australians.

DOI 10.1111/crj.12576
Co-authors John Attia, Roseanne Peel
2018 Jo HE, Prasad JD, Troy LK, Mahar A, Bleasel J, Ellis SJ, et al., 'Diagnosis and management of idiopathic pulmonary fibrosis: Thoracic Society of Australia and New Zealand and Lung Foundation Australia position statements summary', MEDICAL JOURNAL OF AUSTRALIA, 208 82-+ (2018)
DOI 10.5694/mja17.00799
Citations Web of Science - 1
2018 Schuliga M, Grainge C, Westall G, Knight D, 'The fibrogenic actions of the coagulant and plasminogen activation systems in pulmonary fibrosis', International Journal of Biochemistry and Cell Biology, 97 108-117 (2018) [C1]

© 2018 Elsevier Ltd Fibrosis causes irreversible damage to lung structure and function in restrictive lung diseases such as idiopathic pulmonary fibrosis (IPF). Extravascular coag... [more]

© 2018 Elsevier Ltd Fibrosis causes irreversible damage to lung structure and function in restrictive lung diseases such as idiopathic pulmonary fibrosis (IPF). Extravascular coagulation involving fibrin formation in the intra-alveolar compartment is postulated to have a pivotal role in the development of pulmonary fibrosis, serving as a provisional matrix for migrating fibroblasts. Furthermore, proteases of the coagulation and plasminogen activation (plasminergic) systems that form and breakdown fibrin respectively directly contribute to pulmonary fibrosis. The coagulants, thrombin and factor Xa (FXa) evoke fibrogenic effects via cleavage of the N-terminus of protease-activated receptors (PARs). Whilst the formation and activity of plasmin, the principle plasminergic mediator is suppressed in the airspaces of patients with IPF, localized increases are likely to occur in the lung interstitium. Plasmin-evoked proteolytic activation of factor XII (FXII), matrix metalloproteases (MMPs) and latent, matrix-bound growth factors such as epidermal growth factor (EGF) indirectly implicate plasmin in pulmonary fibrosis. Another plasminergic protease, urokinase plasminogen activator (uPA) is associated with regions of fibrosis in the remodelled lung of IPF patients and elicits fibrogenic activity via binding its receptor (uPAR). Plasminogen activator inhibitor-1 (PAI-1) formed in the injured alveolar epithelium also contributes to pulmonary fibrosis in a manner that involves vitronectin binding. This review describes the mechanisms by which components of the two systems primarily involved in fibrin homeostasis contribute to interstitial fibrosis, with a particular focus on IPF. Selectively targeting the receptor-mediated mechanisms of coagulant and plasminergic proteases may limit pulmonary fibrosis, without the bleeding complications associated with conventional anti-coagulant and thrombolytic therapies.

DOI 10.1016/j.biocel.2018.02.016
Co-authors Michael Schuliga, Darryl Knight
2018 Jo HE, Glaspole I, Goh N, Hopkins PMA, Moodley Y, Reynolds PN, et al., 'Implications of the diagnostic criteria of idiopathic pulmonary fibrosis in clinical practice: Analysis from the Australian Idiopathic Pulmonary Fibrosis Registry.', Respirology, (2018)
DOI 10.1111/resp.13427
2017 Williamson JP, Twaddell SH, Lee YCG, Salamonsen M, Hew M, Fielding D, et al., 'Thoracic ultrasound recognition of competence: A position paper of the Thoracic Society of Australia and New Zealand', Respirology, 22 405-408 (2017) [C1]

© 2017 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology The ability to perform bedside thoracic ultra... [more]

© 2017 The Authors. Respirology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Respirology The ability to perform bedside thoracic ultrasound is increasingly recognized as an essential skill for thoracic clinicians, extending the clinical examination and aiding diagnostic and therapeutic procedures. Thoracic ultrasound reduces complications and increases success rates when used prior to thoracentesis or intercostal chest tube insertion. It is increasingly difficult to defend performing these procedures without real or near-real time image guidance. To assist thoracic physicians and others achieve and demonstrate thoracic ultrasound competence, the Interventional Pulmonology Special Interest Group (IP-SIG) of the Thoracic Society of Australia and New Zealand (TSANZ) has developed a new pathway with four components: (i) completion of an approved thoracic ultrasound theory and hands-on teaching course. (ii) A log of at least 40 relevant scans. (iii) Two formative assessments (following 5¿10 scans and again after 20 scans) using the Ultrasound-Guided Thoracentesis Skills and Tasks Assessment Tool (UG-STAT). (iv) A barrier assessment (UG-STAT, pass score of 90%) by an accredited assessor not directly involved in the candidate's training. Upon completion of these requirements a candidate may apply to the TSANZ for recognition of competence. This pathway is intended to provide a regional standard for thoracic ultrasound training.

DOI 10.1111/resp.12977
Citations Scopus - 6Web of Science - 8
2017 Murray LA, Grainge C, Wark PA, Knight DA, 'Use of biologics to treat acute exacerbations and manage disease in asthma, COPD and IPF', Pharmacology and Therapeutics, 169 1-12 (2017) [C1]

© 2016 Elsevier Inc. A common feature of chronic respiratory disease is the progressive decline in lung function. The decline can be indolent, or it can be accelerated by acute ex... [more]

© 2016 Elsevier Inc. A common feature of chronic respiratory disease is the progressive decline in lung function. The decline can be indolent, or it can be accelerated by acute exacerbations, whereby the patient experiences a pronounced worsening of disease symptoms. Moreover, acute exacerbations may also be a marker of insufficient disease management. The underlying cause of an acute exacerbation can be due to insults such as pathogens or environmental pollutants, or the cause can be unknown. For each acute exacerbation, the patient may require medical intervention such as rescue medication, or in more severe cases, hospitalization and ventilation and have an increased risk of death. Biologics, such as monoclonal antibodies, are being developed for chronic respiratory diseases including asthma, COPD and IPF. This therapeutic approach is particularly well suited for chronic use based on the route and frequency of delivery and importantly, the potential for disease modification. In recent clinical trials, the frequency of acute exacerbation has often been included as an endpoint, to help determine whether the investigational agent is impacting disease. Therefore the significance of acute exacerbations in driving disease, and their potential as a marker of disease activity and progression, has recently received much attention. There is also now a need to standardize the definition of an acute exacerbation in specific disease settings, particularly as this endpoint is increasingly used in clinical trials to also assess therapeutic efficacy. Moreover, specifically targeting exacerbations may offer a new therapeutic approach for several chronic respiratory diseases.

DOI 10.1016/j.pharmthera.2016.11.003
Co-authors Peter Wark, Darryl Knight
2017 Glaspole IN, Watson AL, Allan H, Chapman S, Cooper WA, Corte TJ, et al., 'Determinants and outcomes of prolonged anxiety and depression in idiopathic pulmonary fibrosis', EUROPEAN RESPIRATORY JOURNAL, 50 (2017)
DOI 10.1183/13993003.00168-2017
Citations Scopus - 2Web of Science - 1
2017 Schuliga M, Jaffar J, Berhan A, Langenbach S, Harris T, Waters D, et al., 'Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity', American Journal of Physiology - Lung Cellular and Molecular Physiology, 312 L772-L782 (2017) [C1]

© 2017 the American Physiological Society. In lung injury and disease, including idiopathic pulmonary fibrosis (IPF), extravascular factor X is converted into factor Xa (FXa), a c... [more]

© 2017 the American Physiological Society. In lung injury and disease, including idiopathic pulmonary fibrosis (IPF), extravascular factor X is converted into factor Xa (FXa), a coagulant protease with fibrogenic actions. Extracellular annexin A2 binds to FXa, augmenting activation of the protease-activated receptor-1 (PAR-1). In this study, the contribution of annexin A2 in lung injury and fibrosis was investigated. Annexin A2 immunoreactivity was observed in regions of fibrosis, including those associated with fibroblasts in lung tissue of IPF patients. Furthermore, annexin A2 was detected in the conditioned media and an EGTA membrane wash of human lung fibroblast (LF) cultures. Incubation with human plasma (5% vol/vol) or purified FXa (15¿50 nM) evoked fibrogenic responses in LF cultures, with FXa increasing interleukin-6 (IL-6) production and cell number by 270 and 46%, respectively (P < 0.05, n = 5¿8). The fibrogenic actions of plasma or FXa were attenuated by the selective FXa inhibitor apixaban (10 µM, or antibodies raised against annexin A2 or PAR-1 (2 µg/ml). FXastimulated LFs from IPF patients (n = 6) produced twice as much IL-6 as controls (n = 10) (P < 0.05), corresponding with increased levels of extracellular annexin A2. Annexin A2 gene deletion in mice reduced bleomycin-induced increases in bronchoalveolar lavage fluid (BALF) IL-6 levels and cell number (*P < 0.05; n = 4¿12). Lung fibrogenic gene expression and dry weight were reduced by annexin A2 gene deletion, but lung levels of collagen were not. Our data suggest that annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa. Extracellular annexin A2 is a potential target for the treatment of IPF.

DOI 10.1152/ajplung.00553.2016
Citations Scopus - 4Web of Science - 2
Co-authors Michael Schuliga, Darryl Knight
2017 Jo HE, Glaspole I, Grainge C, Goh N, Hopkins PMA, Moodley Y, et al., 'Baseline characteristics of idiopathic pulmonary fibrosis: analysis from the Australian Idiopathic Pulmonary Fibrosis Registry', EUROPEAN RESPIRATORY JOURNAL, 49 (2017)
DOI 10.1183/13993003.01592-2016
Citations Web of Science - 8
2017 Jo HE, Troy LK, Keir G, Chambers DC, Holland A, Goh N, et al., 'Treatment of idiopathic pulmonary fibrosis in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia', Respirology, 22 1436-1458 (2017) [C1]
DOI 10.1111/resp.13146
Citations Scopus - 7Web of Science - 5
2017 Liu G, Cooley MA, Nair PM, Donovan C, Hsu AC, Jarnicki AG, et al., 'Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c', JOURNAL OF PATHOLOGY, 243 510-523 (2017) [C1]
DOI 10.1002/path.4979
Citations Scopus - 5Web of Science - 3
Co-authors Paul Foster, Peter Wark, Gang Liu, Alan Hsu, Philip Hansbro, Jay Horvat, Hock Tay, Darryl Knight, Chantal Donovan, Nicole Hansbro
2016 Grainge C, Thomas PS, Mak JCW, Benton MJ, Lim TK, Ko FWS, 'Year in review 2015: Asthma and chronic obstructive pulmonary disease', RESPIROLOGY, 21 765-775 (2016)
DOI 10.1111/resp.12771
Citations Scopus - 6Web of Science - 6
2016 Mackay RMA, Grainge CL, Lau LC, Barber C, Clark HW, Howarth PH, 'Airway surfactant protein D deficiency in adults with severe asthma', Chest, 149 1165-1172 (2016) [C1]

Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. BACKGROUND: Surfactant protein D (SP-D) is an essential component of the inn... [more]

Copyright © 2016 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. BACKGROUND: Surfactant protein D (SP-D) is an essential component of the innate immune defense against pathogens within the airways. SP-D also regulates allergic inflammation and promotes the removal of apoptotic cells. SP-D dysregulation is evident in several pulmonary diseases. Our aim was to investigate whether airway and serum levels of SP-D are altered in treatment-resistant severe asthma. METHODS: SP-D concentrations were measured in matched serum and BAL samples collected from 10 healthy control subjects (HC) and 50 patients with asthma (22 with mild asthma [MA] and 28 with severe asthma [SA]). These samples were also evaluated by using Western blot analysis to investigate variations in SP-D size. RESULTS: SP-D levels in BAL samples were significantly lower in SA compared with HC and MA (P < .001) and inversely correlated with BAL eosinophil cationic protein concentrations in SA (P < .01). Serum SP-D was significantly increased in SA compared with HC and MA (P < .001), and BAL/serum ratios were significantly lower in SA compared with HC and MA (P < .001). Reduced SP-D levels in BAL samples, with concomitant increases in serum in SA, were associated with degraded fragments of SP-D in the serum and increased BAL neutrophil counts and lipopolysaccharide levels. CONCLUSIONS: These findings suggest defective innate immunity within the airways in SA, as reflected by low BAL SP-D concentrations and altered bacterial presence with airway neutrophilia. Furthermore, BAL SP-D leakage into the serum in patients with SA may provide a peripheral blood biomarker, reflecting increased epithelial damage and/or epithelial permeability within the peripheral airways.

DOI 10.1016/j.chest.2015.11.012
Citations Scopus - 18Web of Science - 15
2016 Hill AR, Donaldson JE, Blume C, Smithers N, Tezera L, Tariq K, et al., 'IL-1 alpha mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit', TISSUE BARRIERS, 4 (2016) [C1]
DOI 10.1080/21688370.2016.1206378
Citations Scopus - 1Web of Science - 1
2016 Rupani H, Martinez-Nunez RT, Dennison P, Lau LCK, Jayasekera N, Havelock T, et al., 'Toll-like Receptor 7 Is Reduced in Severe Asthma and Linked to an Altered MicroRNA Profile', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 194 26-37 (2016) [C1]
DOI 10.1164/rccm.201502-0280OC
Citations Scopus - 15Web of Science - 12
2016 Mahmoodi E, Grainge C, Erdstein A, O'kane G, 'Septic arthritis caused by pet rodents: A diagnostic dilemma', AUSTRALASIAN MEDICAL JOURNAL, 9 270-273 (2016)
DOI 10.4066/AMJ.2016.2661
2016 Mackay R-MA, Grainge CL, Lau LC, Barber C, Clark HW, Howarth PH, 'Serum Surfactant Protein D as a Marker of Asthma Severity Response', CHEST, 150 474-474 (2016)
DOI 10.1016/j.chest.2016.05.033
2015 Gosens R, Grainge C, 'Bronchoconstriction and airway biology: Potential impact and therapeutic opportunities', Chest, 147 798-803 (2015) [C1]

© 2015 American College of Chest Physicians. Recent work has demonstrated that mechanical forces occurring in the airway as a consequence of bronchoconstriction are sufficient to ... [more]

© 2015 American College of Chest Physicians. Recent work has demonstrated that mechanical forces occurring in the airway as a consequence of bronchoconstriction are sufficient to not only induce symptoms but also influence airway biology. Animal and human in vitro and in vivo work demonstrates that the airways are structurally and functionally altered by mechanical stress induced by bronchoconstriction. Compression of the airway epithelium and mechanosensing by the airway smooth muscle trigger the activation and release of growth factors, causing cell proliferation, extracellular matrix protein accumulation, and goblet cell differentiation. These effects of bronchoconstriction are of major importance to asthma pathophysiology and appear sufficient to induce remodeling independent of the inflammatory response. We review these findings in detail and discuss previous studies in light of this new evidence regarding the influence of mechanical forces in the airways. Furthermore, we highlight potential impacts of therapies influencing mechanical forces on airway structure and function in asthma.

DOI 10.1378/chest.14-1142
Citations Scopus - 23Web of Science - 19
2015 Lim TK, Ko FW, Thomas PS, Grainge C, Yang IA, 'Year in review 2014: Chronic obstructive pulmonary disease, asthma and airway biology', Respirology, (2015) [C3]
DOI 10.1111/resp.12488
2015 Sarwar G, de Malmanche T, Rassam L, Grainge C, Williams A, Arnold D, 'Chronic granulomatous disease presenting as refractory pneumonia in late adulthood.', Respirology Case Reports, 3 54-56 (2015) [C3]
DOI 10.1002/rcr2.99
Citations Scopus - 3Web of Science - 2
2015 Tayler N, Grainge C, Gove K, Howarth P, Holloway J, 'Clinical assessment of speech correlates well with lung function during induced bronchoconstriction', Primary Care Respiratory Medicine, 25 (2015) [C1]

© 2015 Primary Care Respiratory Society UK/Macmillan Publishers Limited. Clinical assessment of asthma often includes a crude assessment of speech, for example whether the patient... [more]

© 2015 Primary Care Respiratory Society UK/Macmillan Publishers Limited. Clinical assessment of asthma often includes a crude assessment of speech, for example whether the patient can speak in full sentences. To date, this statement, despite appearing in national asthma guidelines, has not been related to lung function testing in asthma exacerbation. Seven asthmatics underwent a bronchial challenge and were then recorded reading a standardised text for 1 min. The recordings were played to 88 healthcare professionals who were asked to estimate FEV1% predicted. Health care professionals' estimations showed moderate correlation to FEV1% predicted (rho = 0.61 Po0.01). There were no significant differences between professionals grouped by seniority or speciality. Speech can intuitively be estimated by health care professionals with moderate accuracy. This gives an evidence basis for the assessment in speech in acute asthma and may provide a new avenue for monitoring.

DOI 10.1038/npjpcrm.2015.6
Citations Web of Science - 1
2014 Grainge C, Dennison P, Lau L, Davies D, Howarth P, 'Asthmatic and Normal Respiratory Epithelial Cells Respond Differently to Mechanical Apical Stress', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 190 477-480 (2014) [C1]
DOI 10.1164/rccm.201401-0107LE
Citations Scopus - 9Web of Science - 7
2014 Green BJ, Wiriyachaiporn S, Grainge C, Rogers GB, Kehagia V, Lau L, et al., 'Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma', PLOS ONE, 9 (2014) [C1]
DOI 10.1371/journal.pone.0100645
Citations Scopus - 89Web of Science - 82
2013 Grainge CL, Davies DE, 'Epithelial Injury and Repair in Airways Diseases', CHEST, 144 1906-1912 (2013) [C1]
DOI 10.1378/chest.12-1944
Citations Scopus - 40Web of Science - 39
2013 Grainge C, Jayasekera N, Dennison P, Rupani H, Kurukulaaratchy R, Howarth P, 'Case series reporting the effectiveness of mycophenolate mofetil in treatment-resistant asthma', EUROPEAN RESPIRATORY JOURNAL, 42 1134-1137 (2013) [C1]
DOI 10.1183/09031936.00026413
Citations Scopus - 2Web of Science - 3
2013 Grainge C, Jayasekera N, Dennison P, Rupani H, Kurukulaaratchy R, Howarth P, 'MYCOPHENOLATE MOFETIL IMPROVES LUNG FUNCTION AND SYMPTOMS IN SEVERE TREATMENT RESISTANT ASTHMA', RESPIROLOGY, 18 12-12 (2013) [E3]
2012 Grainge C, Dulay V, Ward J, Lau L, Cottey L, Haitchi HM, et al., 'RESISTIN-LIKE MOLECULE BETA IN BRONCHIAL EPITHELIUM INCREASES WITH ASTHMA SEVERITY AND AIRWAY CHALLENGES', RESPIROLOGY, 17 26-26 (2012) [E3]
2012 Grainge C, Dennison P, Davies DE, Howarth PH, 'COMPRESSION STIMULATES TGF beta 2 RELEASE FROM ASTHMATIC BUT NOT NORMAL PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY, 17 42-42 (2012) [E3]
2012 Grainge C, Dragolea N, Howarth PH, 'ALLERGEN CHALLENGE INCREASES ALTERNATIVELY ACTIVATED MACROPHAGES WITHIN THE AIRWAYS IN ALLERGIC ASTHMA', RESPIROLOGY, 17 51-51 (2012) [E3]
2012 Grainge C, Dulay V, Ward J, Sammut D, Davies E, Green B, et al., 'Resistin-like molecule-beta is induced following bronchoconstriction of asthmatic airways', RESPIROLOGY, 17 1094-1100 (2012) [C1]
DOI 10.1111/j.1440-1843.2012.02215.x
Citations Scopus - 9Web of Science - 9
2011 Grainge C, Howarth PH, 'Repeated high-dose inhalation allergen challenge in asthma', CLINICAL RESPIRATORY JOURNAL, 5 150-155 (2011) [C1]
DOI 10.1111/j.1752-699X.2010.00212.x
Citations Scopus - 8Web of Science - 9
2011 Grainge CL, Lau LCK, Ward JA, Dulay V, Lahiff G, Wilson S, et al., 'Effect of Bronchoconstriction on Airway Remodeling in Asthma', NEW ENGLAND JOURNAL OF MEDICINE, 364 2006-2015 (2011) [C1]
DOI 10.1056/NEJMoa1014350
Citations Scopus - 306Web of Science - 269
2011 Grainge CL, Howarth PH, 'Bronchoconstriction and Airway Remodeling REPLY', NEW ENGLAND JOURNAL OF MEDICINE, 365 1157-1157 (2011)
2011 Grainge CL, Howarth PH, 'The authors reply', New England Journal of Medicine, 365 1157 (2011)
2011 Cakebread JA, Xu Y, Grainge C, Kehagia V, Howarth PH, Holgate ST, Davies DE, 'Exogenous IFN-beta has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 127 1148-U416 (2011) [C1]
DOI 10.1016/j.jaci.2011.01.023
Citations Scopus - 77Web of Science - 67
2010 Grainge C, Jugg BJ, Smith AJ, Brown RFR, Jenner J, Parkhouse DA, Rice P, 'Delayed low-dose supplemental oxygen improves survival following phosgene-induced acute lung injury', INHALATION TOXICOLOGY, 22 552-560 (2010)
DOI 10.3109/08958370903571831
Citations Web of Science - 15
2010 Grainge C, Rice P, 'Management of phosgene-induced acute lung injury', CLINICAL TOXICOLOGY, 48 497-508 (2010) [D1]
DOI 10.3109/15563650.2010.506877
Citations Web of Science - 33
2010 Grainge C, Smith AJ, Jugg BJ, Fairhall SJ, Mann T, Perrott R, et al., 'Furosemide in the treatment of phosgene induced acute lung injury.', Journal of the Royal Army Medical Corps, 156 245-250 (2010)
DOI 10.1136/jramc-156-04-09
2010 Hatzivlassiou M, Grainge C, Kehagia V, Lau L, Howarth PH, 'The allergen specificity of the late asthmatic reaction', ALLERGY, 65 355-358 (2010)
DOI 10.1111/j.1398-9995.2009.02184.x
Citations Scopus - 21Web of Science - 18
2009 Grainge C, Brown R, Jugg BJ, Smith AJ, Mann TM, Jenner J, et al., 'Early treatment with nebulised salbutamol worsens physiological measures and does not improve survival following phosgene induced acute lung injury.', Journal of the Royal Army Medical Corps, 155 105-109 (2009)
DOI 10.1136/jramc-155-02-05
2005 Grainge C, Traer E, Fulton J, 'Do weekend plan standard forms improve communication and influence quality of patient care?', POSTGRADUATE MEDICAL JOURNAL, 81 524-525 (2005)
DOI 10.1136/pgmj.2004.030064
Citations Web of Science - 7
2005 Grainge C, Heber M, 'The role of the physician in modern military operations: 12 months experience in Southern Iraq.', Journal of the Royal Army Medical Corps, 151 101-104 (2005)
DOI 10.1136/jramc-151-02-08
2005 Grainge C, Nokes T, 'Cerebral arterial thrombosis in a young woman following vasopressin for von Willebrand's disease.', Thrombosis and haemostasis, 93 380 (2005)
2004 Grainge C, 'Breath of life: the evolution of oxygen therapy.', Journal of the Royal Society of Medicine, 97 489-493 (2004)
DOI 10.1258/jrsm.97.10.489
2001 Blanco G, Coulton GR, Biggin A, Grainge C, Moss J, Barrett M, et al., 'The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein', HUMAN MOLECULAR GENETICS, 10 9-16 (2001)
DOI 10.1093/hmg/10.1.9
Citations Scopus - 57Web of Science - 54
Show 46 more journal articles

Review (1 outputs)

Year Citation Altmetrics Link
2016 Grainge CL, Maltby S, Gibson PG, Wark PAB, McDonald VM, 'Targeted therapeutics for severe refractory asthma: monoclonal antibodies', EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2016)
DOI 10.1586/17512433.2016.1172208
Citations Scopus - 6Web of Science - 11
Co-authors Vanessa Mcdonald, Peter Gibson, Peter Wark, Steven Maltby

Conference (28 outputs)

Year Citation Altmetrics Link
2018 Schuliga M, Waters D, Blokland K, Jaffar J, Westall G, Burgess J, et al., 'MITOCHONDRIAL DYSFUNCTION REINFORCES THE SENESCENT PHENOTYPE IN IPF LUNG FIBROBLASTS', RESPIROLOGY (2018)
Co-authors Andrew Reid, Michael Schuliga, Darryl Knight
2018 Reid A, Nichol K, Wei L, Moheimani F, Bartlett N, Hansbro P, et al., 'NOTCH3 INHIBITION SIGNIFICANTLY REDUCES MUC5AC IN HUMAN AIRWAY EPITHELIAL CELLS', RESPIROLOGY (2018)
Co-authors Fatemeh Moheimani, Peter Wark, Darryl Knight, Philip Hansbro, Nathan Bartlett
2018 Blokland K, Waters D, Schuliga M, Grainge C, Mutsaers S, Prele C, et al., 'SENESCENT LUNG FIBROBLASTS ATTENUATE ALVEOLAR EPITHELIAL CELL PROLIFERATION AND MIGRATION IN IPF', RESPIROLOGY (2018)
Co-authors Michael Schuliga, Darryl Knight
2018 Waters D, Schuliga M, Blockland K, Burgess J, Grainge C, Westall G, et al., 'STAT3 ACTIVATION REINFORCES SENESCENCE IN HUMAN LUNG FIBROBLASTS', RESPIROLOGY (2018)
Co-authors Darryl Knight, Michael Schuliga
2018 Sarwar G, Grainge C, Arnold D, 'PARATHYROID ADENOMA DIAGNOSED WITH ENDOSCOPIC ULTRASOUND WITH BRONCHOSCOPE (EUS-B) GUIDED BIOPSY IN ASYMPTOMATIC PATIENT WITH PRIMARY HYPERPARATHYROIDISM', RESPIROLOGY (2018)
2017 Veerati P, Bartlett N, Parsons K, Moheimani F, Wark P, Knight D, Grainge C, 'MECHANICAL FORCES ATTENUATE ANTI-VIRAL IMMUNITY IN PRIMARY HUMAN AIRWAY EPITHELIAL CELLS FROM ASTHMATIC DONORS', RESPIROLOGY (2017)
Co-authors Nathan Bartlett, Fatemeh Moheimani, Darryl Knight, Peter Wark
2017 Reid A, Moheimani F, Nichol K, Bartlett N, Wark P, Grainge C, Knight D, 'ACUTE INHIBITION OF NOTCH SIGNALLING ABLATES MUC5AC PRODUCTION IN HUMAN AIRWAY EPITHELIAL CELLS FROM ASTHMATIC, NON-ASTHMATIC AND COPD DONORS.', RESPIROLOGY (2017)
Co-authors Fatemeh Moheimani, Peter Wark, Andrew Reid, Darryl Knight, Nathan Bartlett
2017 Waters DW, Schuliga M, Fogarty E, Burgess JK, Grainge C, Westall G, et al., 'Dysregulated Stat3 Signaling Induces And Reinforces Fibroblast Senescence In Lung Fibroblasts Of Ipf Patients', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Washington, DC (2017)
Co-authors Darryl Knight, Michael Schuliga
2017 Fogarty E, Waters D, Grainge C, Burgess JK, Prele CM, Laurent G, et al., 'Senescent Lung Fibroblasts Reduce Alveolar Epithelial Cell Number In Co-Culture', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Washington, DC (2017)
Co-authors Darryl Knight, Michael Schuliga
2017 Reid AT, Moheimani F, Nichol K, Bartlett N, Wark PAB, Grainge C, et al., 'Short-Term Inhibition Of Notch Signalling Ablates Muc5ac Production In Human Airway Epithelial Cells From Asthmatic, Non-Asthmatic And COPD Donors', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Washington, DC (2017)
Co-authors Darryl Knight, Peter Wark, Nathan Bartlett, Fatemeh Moheimani, Andrew Reid, Philip Hansbro
2017 Schuliga M, Pechkovsky D, Waters DW, Fogarty E, Khalil N, Burgess JK, et al., 'Lung Fibroblasts Of Ipf Patients Display Senescence-Like Features In Vitro', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Washington, DC (2017)
Co-authors Michael Schuliga, Darryl Knight
2017 Jo HE, Glaspole I, Grainge C, Goh NS, Hopkins P, Moodley Y, et al., 'Patient Reported Outcome Measures In Idiopathic Pulmonary Fibrosis: Analysis From The Australian Ipf Registry', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Washington, DC (2017)
2017 Jo HE, Corte TJ, Glaspole I, Grainge C, Goh NS, Hopkins P, et al., 'Biomarkers Can Predict Disease Progression In Idiopathic Pulmonary Fibrosis: Analysis From The Australian Ipf Registry', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Washington, DC (2017)
2017 Burgess A, Goon K, Attia J, Palazzi K, Brannan J, Grainge C, 'ELIGIBILITY FOR ANTI-FIBROTIC TREATMENT IN IDIOPATHIC PULMONARY FIBROSIS (IPF) DEPENDS ON THE PREDICTIVE EQUATION USED IN PULMONARY FUNCTION TESTING', RESPIROLOGY (2017)
Co-authors John Attia
2017 Jo HE, Corte TJ, Glaspole I, Grainge C, Goh N, Hopkins PM, et al., 'BIOMARKERS CAN PREDICT DISEASE PROGRESSION IN IDIOPATHIC PULMONARY FIBROSIS: ANALYSIS FROM THE AUSTRALIAN IPF REGISTRY', RESPIROLOGY (2017)
2017 Dunn E, Vos W, De Backer J, Brannan JD, Soans B, Grainge C, 'FUNCTIONAL RESPIRATORY IMAGING DEMONSTRATES HETEROGENEOUS ALTERATIONS IN AIRWAY MECHANICS AND AIRFLOW DURING BRONCHOCONSTRICTION', RESPIROLOGY (2017)
2017 Jo HE, Glaspole I, Grainge C, Goh N, Hopkins PMA, Moodley Y, et al., 'PATIENT REPORTED OUTCOME MEASURES IN IDIOPATHIC PULMONARY FIBROSIS: ANALYSIS FROM THE AUSTRALIAN IPF REGISTRY', RESPIROLOGY (2017)
2017 Schuliga M, Pechkovsky DV, Waters D, Fogarty E, Hogaboam CM, Yao E, et al., 'LUNG FIBROBLASTS OF IPF PATIENTS DISPLAY SENESCENCE-LIKE FEATURES IN VITRO', RESPIROLOGY (2017)
Co-authors Darryl Knight, Michael Schuliga
2017 Waters DW, Schuliga M, Fogarty E, Burgess J, Grainge C, Westall G, et al., 'DYSREGULATED STAT3 SIGNALING INDUCES AND REINFORCES FIBROBLAST SENESCENCE IN LUNG FIBROBLASTS OF IPF PATIENTS', RESPIROLOGY (2017)
Co-authors Darryl Knight, Michael Schuliga
2017 Jo H, Corte T, Glaspole I, Hopkins P, Moodley Y, Reynolds P, et al., 'GASTROESOPHAGEAL REFLUX IN IDIOPATHIC PULMONARY FIBROSIS: ANALYSIS FROM THE AUSTRALIAN IPF REGISTRY', RESPIROLOGY (2017)
2016 Glaspole I, Watson A, Macansh S, Chapman S, Cooper W, Allan H, et al., 'ANXIETY AND DEPRESSION IN IDIOPATHIC PULMONARY FIBROSIS', RESPIROLOGY (2016)
2016 Arnold A, Arnold D, Twaddell S, Gupta S, Grainge C, 'ANTHRACOSIS CAN CAUSE POSITRON EMISSION TOMOGRAPHY POSITIVE MEDIASTINAL AND HILAR LYMPHADENOPATHY, MIMICKING MALIGNANCY', RESPIROLOGY (2016)
2016 Glaspole I, Watson A, Macansh S, Chapman S, Cooper W, Allan H, et al., 'Anxiety And Depression In Idiopathic Pulmonary Fibrosis', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, San Francisco, CA (2016)
2016 Jo H, Glaspole I, Goh N, Hopkins P, Moodley Y, Reynolds P, et al., 'Baseline Pulmonary Function Test Predicts Survival: Analysis From The Australian Ipf Registry', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, San Francisco, CA (2016)
2015 Glaspole I, Goh N, Hopkins P, Moodley Y, Reynolds PN, Walters E, et al., 'Multidisciplinary Review Of Idiopathic Pulmonary Fibrosis (ipf) Patients: Review Of Clinical Diagnosis For Patients Referred To The Australian Ipf Registry', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Denver, CO (2015)
2014 Hill A, Tezera L, Blume C, Grainge C, Davies DE, Swindle EJ, 'ROLE FOR IL-1ALPHA IN VIRAL-INDUCED INFLAMMATORY RESPONSES IN A CO-CULTURE MODEL OF THE AIRWAY MUCOSA', THORAX, London, ENGLAND (2014) [E3]
DOI 10.1136/thoraxjnl-2014-206260.96
2010 Cottey L, Jayasekera N, Haitchi H-M, Green B, Grainge C, Howarth P, 'AIRWAY EPITHELIAL TOLL RECEPTOR EXPRESSION IN ASTHMA AND ITS RELATIONSHIP TO DISEASE SEVERITY', THORAX, Westminster, ENGLAND (2010)
DOI 10.1136/thx.2010.150912.42
Citations Web of Science - 2
2009 Dulay V, Grainge C, Howarth P, 'Transforming growth factor-beta and resistin-like molecule-alpha are upregulated in asthmatic airways following both repeated allergen and methacholine inhalation', EUROPEAN JOURNAL OF MEDICAL RESEARCH (2009)
Show 25 more conferences
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Grants and Funding

Summary

Number of grants 21
Total funding $3,946,889

Click on a grant title below to expand the full details for that specific grant.


20183 grants / $1,089,818

How does bronchoconstriction worsen asthma? $1,067,511

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Christopher Grainge, Associate Professor Nathan Bartlett, Professor Darryl Knight, Conjoint Professor Peter Wark, Professor Alastair Stewart, Stewart, Alastair
Scheme Project Grant
Role Lead
Funding Start 2018
Funding Finish 2021
GNo G1700343
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The role of apical mechanical shear stress on epithelial cell function in asthma$17,307

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Andrew Reid, Mr Punnam Veerati, Conjoint Associate Professor Christopher Grainge
Scheme Research Grant
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo G1800434
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

Annexin A2 in IPF and potential as novel therapeutic target$5,000

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team Doctor Michael Schuliga, Professor Darryl Knight, Conjoint Associate Professor Christopher Grainge
Scheme Lizotte Family Research Award for Interstitial Pulmonary Fibrosis Research
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo G1801058
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

20176 grants / $954,058

Anti-viral immune dysfunction in severe asthma varies across inflammatory phenotypes$444,633

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jodie Simpson, Professor John Upham, Conjoint Associate Professor Christopher Grainge
Scheme Project Grant
Role Investigator
Funding Start 2017
Funding Finish 2019
GNo G1700111
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Imaging treatable traits$399,186

Funding body: Cyclopharm Limited

Funding body Cyclopharm Limited
Project Team Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Natalie Rutherford, Conjoint Professor Peter Wark, Conjoint Associate Professor Christopher Grainge
Scheme Research Grant
Role Investigator
Funding Start 2017
Funding Finish 2018
GNo G1700386
Type Of Funding C3111 - Aust For profit
Category 3111
UON Y

Does bronchoconstriction in asthma impair anti-viral immunity and promote airway inflammation$75,000

Funding body: Royal Australasian College of Physicians

Funding body Royal Australasian College of Physicians
Project Team Conjoint Associate Professor Christopher Grainge
Scheme Research Funding
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1700559
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Mechano-transduction signaling complexes of urokinase and its receptor in lung fibrosis: A potential target for idiopathic pulmonary fibrosis (IPF)$20,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Michael Schuliga, Conjoint Associate Professor Christopher Grainge, Professor Darryl Knight
Scheme Research Funding
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1700697
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

Registry Coordinator – Australian Idiopathic Pulmonary Fibrosis (IPF) Registry$9,397

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team Conjoint Associate Professor Christopher Grainge
Scheme Research Award
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1701503
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

2017 International Visitor from Harvard University, USA$5,842

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Christopher Grainge, Associate Professor Jin-Ah Park
Scheme International Research Visiting Fellowship
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1600876
Type Of Funding Internal
Category INTE
UON Y

20163 grants / $452,917

Collaborative Research Agreement: New pathways and targets in severe asthma and COPD$411,172

Funding body: Boehringer Ingelheim Pharma GmbH & Co KG

Funding body Boehringer Ingelheim Pharma GmbH & Co KG
Project Team Professor Darryl Knight, Conjoint Associate Professor Christopher Grainge, Conjoint Professor Peter Wark, Associate Professor Nathan Bartlett
Scheme Research Grant
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1601257
Type Of Funding C3211 - International For profit
Category 3211
UON Y

Cryobiopsy versus open lung biopsy in the diagnosis of interstitial lung disease$21,745

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Conjoint Associate Professor Christopher Grainge, Dr Lauren Troy
Scheme Research Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1601016
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

Inflammation based management of severe asthma: utility of blood oesinophils$20,000

Funding body: National Clinical CRE in Severe Asthma

Funding body National Clinical CRE in Severe Asthma
Project Team Conjoint Professor Peter Wark, Professor Jodie Simpson, Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Conjoint Associate Professor Christopher Grainge
Scheme Seed Research Project
Role Investigator
Funding Start 2016
Funding Finish 2016
GNo G1601079
Type Of Funding Internal
Category INTE
UON Y

20151 grants / $25,222

Do viral infection and bronchoconstriction interact during exacerbation of asthma prolonging viral infection and worsening disease in the long term?$25,222

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Conjoint Associate Professor Christopher Grainge, Professor Darryl Knight
Scheme Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500546
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20143 grants / $477,974

Investigation of the role of mechanical forces in respiratory disease$245,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Conjoint Associate Professor Christopher Grainge
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2018
GNo G1401248
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

Role of mechanical forces in asthma disease progression$210,474

An examination of the role of mechanical forces in the progression of asthma

Funding body: Respiratory Medicine Charitable Trust John Hunter Hospital

Funding body Respiratory Medicine Charitable Trust John Hunter Hospital
Project Team

Chris Grainge

Scheme Respiratory Medicine Charitable Trust John Hunter Hospital
Role Lead
Funding Start 2014
Funding Finish 2017
GNo
Type Of Funding Not Known
Category UNKN
UON N

Do asthma attacks worsen asthma in the long term?$22,500

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Christopher Grainge, Professor Darryl Knight
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1401402
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20131 grants / $198,000

The role of environmental dust from the Middle East in the pathogenesis of constrictive bronchiolitis$198,000

Recent clinical evidence has suggested that some individuals exposed to high levels of inhaled dusts develop the usually rare lung disease, constrictive bronchiolitis. Using over £220,000 from the British Lung Foundation, the Institute of Life Sciences and the Southampton Marine and Maritime Institution we will investigate the mechanisms underling this finding. This project is a collaboration between the National Oceanography Centre and the University of Southampton.

Funding body: British Lung Foundation and the Insitute for Life Sciences

Funding body British Lung Foundation and the Insitute for Life Sciences
Project Team

CHris Grainge

Scheme British Lung Foundation and the Insitute for Life Sciences, Southampton
Role Lead
Funding Start 2013
Funding Finish 2016
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20121 grants / $36,900

The effect of clopidogrel on allergen-induced airway inflammation in asthma.$36,900

Platelet activation in the lungs occurs following allergen challenge. We hypothesise that inhibiting platelet activation will decrease the eosinophilic inflammation associated with allergen challenge, and may provide an additional therapeutic pathway which has yet to be investigated. The project involves a double blind randomized controlled trial of Clopidogrel, an oral platelet antagonist, and its effects on inhaled allergen challenge. This project is funded by the Asthma, Allergy and Inflammation Research Charity with a contribution to costs from the Southampton Centre for Biomedical Research.

Funding body: Asthma, Allergy and Inflammation Research Charity (AAIRC)

Funding body Asthma, Allergy and Inflammation Research Charity (AAIRC)
Project Team

Chris Grainge

Scheme Asthma, Allergy and Inflammation Research Charity
Role Lead
Funding Start 2012
Funding Finish 2014
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20111 grants / $198,000

Role of mechanical forces in the pathophysiology of asthma.$198,000

My recent work, published in the New England Journal of Medicine, has demonstrated that mechanical forces may play an important role in determining long term changes in human airways. Following the award of £110,000 from the Gerald Kerkut Trust and a University of Southampton Doctoral Training Award we will investigate how the mechanical forces that are associated with airway narrowing in asthma influence the airway.

Funding body: University of Southampton

Funding body University of Southampton
Project Team

Chris Grainge

Scheme Gerald Kerkut Trust and Southampton University Doctoral Training Award
Role Lead
Funding Start 2011
Funding Finish 2015
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20091 grants / $27,000

A novel approach to rapidly screen commercial off the shelf therapies for acute lung injury$27,000

Investigating the mechanisms and potential treatments of chemically induced acute lung injury. This included the development of an in vitro model enabling rapid screening of potential treatments for acute lung injury. Work lead to the award of the Gilbert Blane medal and several peer-reviewed publications.

Funding body: Defence Science and Technology Laboratories

Funding body Defence Science and Technology Laboratories
Project Team

CHris Grainge

Scheme Defence Science and Technology Laboratories
Role Lead
Funding Start 2009
Funding Finish 2009
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20071 grants / $487,000

Airway permeability and reactivity in acute lung injury and allergic asthma$487,000

This project demonstrated for the first time that airway remodelling in asthma can be triggered by bronchoconstriction, rather than by airway inflammation. Work formed the basis of my PhD, and a first author paper in the New England Journal of Medicine.

Funding body: Defence Postgraduate Medical Deanery (DPMD)

Funding body Defence Postgraduate Medical Deanery (DPMD)
Project Team

Chris Grainge

Scheme Defence Postgraduate Medical Deanery
Role Lead
Funding Start 2007
Funding Finish 2010
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N
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Research Supervision

Number of supervisions

Completed2
Current13

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2018 PhD Acute Exacerbation-Idiopathic Pulmonary Fibrosis (AE-IPF): The Role of Alveolar Epithelial Cell Senescence PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2018 PhD The Role of Beta-catenin in the Development of the Asthmatic Epithelial Phenotype PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Extracellular DNA (eDNA) in Pleural Fluid as a Determinant of Pathology and Treatment Response PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2017 PhD The Role of Pulmonary Macrophages and Primary Bronchial Epithelial Cells in Anti-Viral Immune Dysfunction in Severe Asthma PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD An Investigation of Regional Heterogeneity of the Pulmonary Microenvironment in Idiopathic Pulmonary Fibrosis PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2017 PhD Fibroblast Senescence as a Driver of Idiopathic Pulmonary Fibrosis PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD The Cross-Talk Between STAT Proteins Drives Dysfunctional Epithelial Responses to Viruses in Asthma PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2016 PhD Development of Epithelial Targeted Nanoparticles for Asthma Therapy PhD (Pharmacy), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Fibroblast Senescence as a Driver of Idiopathic Pulmonary Fibrosis PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Role of Mechanical Forces in Asthma Pathogenesis PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Principal Supervisor
2013 Masters Non invasive measures of asthma severity Medical Science, University of Southampton Co-Supervisor
2013 PhD The role of environmental dusts in the pathogenesis of lung disease Biological Sciences, University of Southampton Principal Supervisor
2012 PhD Epithelial fibroblast interaction during respiratory virus infection Medical Science, University of Southampton Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2011 Honours Role of bronchoconstriction in asthma Biological Sciences, University of Southampton Co-Supervisor
2010 Honours ROle of bronchoconstriction in asthma Biological Sciences, University of Southampton Co-Supervisor
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Research Opportunities

The role of acute mechanical forces in antiviral respiratory immunity

A funded PhD project examining the effects of technical forces in the lung on antiviral innate immunity.

Employment

Hunter Medical Research Institute - VIVA

25/07/2016 - 26/07/2019

Contact

Conjoint Associate Professor Christopher Grainge


christopher.grainge@newcastle.edu.au

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Conjoint Associate Professor Christopher Grainge

Position

Conjoint Associate Professor
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email christopher.grainge@newcastle.edu.au
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