Dr Gerard Kaiko

Research Fellow

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Dr Kaiko is an NHMRC Career Development Research Fellow and UON research fellow.

Background

Dr Kaiko's PhD studies in respiratory disease and immunology in Australia examined the role of the innate immune system in regulating the interaction between viral infections and asthma. After a stint working in London at NIMR (MRC) with an immunology focus, Dr Kaiko became an NHMRC overseas early career fellow (CJ Martin) and moved to Washington University in St Louis, USA (one of the top medical research centres in the world) in 2013. There he transitioned to the study of adult stem cells, as well as the study of metabolomics and the microbiota in gastrointestinal diseases. In these fields he has published in the world's top tier journals including Cell, 2016 and Science, 2017. His work in microbial metabolomics and disease has been the feature of media articles in multiple international news outlets such as the Huffington Post. While working in the USA, Dr Kaiko was a senior part of a team that developed a novel 3D technology to generate adult epithelial stem cells from all regions of the gastrointestinal and respiratory systems. These stem cells or "spheroids" are cultured in vitro and retain their properties of the mammalian host long term. Only a tiny patient biopsy is required to grow these stem cells in the laboratory. They can then be expanded and re-differentiated into mature "organ-like" tissues to conduct an unlimited array of 3D or 2D tests, including drug discovery, diagnostic tests for personalised medicine, toxicology screening, and better understanding of epithelial biology. 

Current Focus

Dr Kaiko (now an NHMRC CDF) returned to Australia to set up an independent research group with a current and future focus on:

1) The role of metabolites in respiratory diseases such as asthma.

2) The role of epithelial stem cells in tissue regeneration.

3) The function of novel epithelial cell subsets at mucosal barrier surfaces (such as the lung and intestines) and their interaction with other stromal cells and immune cells in health and disease.

4) Developing screening assays for translational medicine using the human adult stem cell technology. In particular, to screen for new therapies for respiratory (cystic fibrosis, asthma, COPD) and gastrointestinal (inflammatory bowel disease and oesophagitis) diseases and run drug toxicology screens. As the healthcare system evolves and more and more therapeutic options become available for mucosal diseases, this stem cell technology will also be used to improve precision medicine through personalised drug-functional assays that can match the right patient to the most optimal therapy in real-time. This has the potential to save tremendous costs and time, and reduces the likelihood of being prescribed a sub-optimal therapy. 

Dr Kaiko maintains strong international collaborations particularly in the USA and UK.

Editorial board member:

Journal of Leukocyte Biology


Qualifications

  • PhD (Immunology & Microbiology), University of Newcastle

Keywords

  • Adult stem cells
  • Asthma
  • COPD
  • Gastrointestinal disease
  • Metabolomics
  • Mucosal Immunology
  • Regenerative medicine
  • Tissue repair

Fields of Research

Code Description Percentage
100404 Regenerative Medicine (incl. Stem Cells and Tissue Engineering) 40
110203 Respiratory Diseases 40
110307 Gastroenterology and Hepatology 20

Professional Experience

UON Appointment

Title Organisation / Department
Research Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
4/01/2017 -  NHMRC CJ Martin fellow The University of Newcastle - Faculty of Health and Medicine
School of Biomedical Sciences and Pharmacy
Australia
1/02/2015 - 1/01/2018 Research Associate Washington University In St. Louis
Pathology and Immunology
United States
10/01/2013 - 31/01/2015 NHMRC CJ Martin (Overseas) fellow Washington University In St. Louis
Pathology and Immunology
United States
1/05/2012 - 1/12/2012 Postdoctoral researcher National Institute of Medical Research (MRC), Mill Hill, London
United Kingdom
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (25 outputs)

Year Citation Altmetrics Link
2018 Ryu SH, Kaiko GE, Stappenbeck TS, 'Cellular differentiation: Potential insight into butyrate paradox?', Molecular and Cellular Oncology, 5 (2018)

© 2018, © 2018 Taylor & Francis Group, LLC. We recently demonstrated that cellular responses to butyrate depend on the differentiation status of the colonic epithelium. Here... [more]

© 2018, © 2018 Taylor & Francis Group, LLC. We recently demonstrated that cellular responses to butyrate depend on the differentiation status of the colonic epithelium. Here, we apply the implications of these findings to cancer biology and discuss discrepancies in the effects of butyrate on cancer progression.

DOI 10.1080/23723556.2016.1212685
2018 Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, et al., 'Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease', The Journal of clinical investigation, 128 5110-5122 (2018)

It is suggested that subtyping of complex inflammatory diseases can be based on genetic susceptibility and relevant environmental exposure (G+E). We propose that using matched cel... [more]

It is suggested that subtyping of complex inflammatory diseases can be based on genetic susceptibility and relevant environmental exposure (G+E). We propose that using matched cellular phenotypes in human subjects and corresponding preclinical models with the same G+E combinations is useful to this end. As an example, defective Paneth cells can subtype Crohn's disease (CD) subjects; Paneth cell defects have been linked to multiple CD susceptibility genes and are associated with poor outcome. We hypothesized that CD susceptibility genes interact with cigarette smoking, a major CD environmental risk factor, to trigger Paneth cell defects. We found that both CD subjects and mice with ATG16L1T300A (T300A; a prevalent CD susceptibility allele) developed Paneth cell defects triggered by tobacco smoke. Transcriptional analysis of full-thickness ileum and Paneth cell-enriched crypt base cells showed the T300A-smoking combination altered distinct pathways, including proapoptosis, metabolic dysregulation, and selective downregulation of the PPAR¿ pathway. Pharmacologic intervention by either apoptosis inhibitor or PPAR¿ agonist rosiglitazone prevented smoking-induced crypt apoptosis and Paneth cell defects in T300A mice and mice with conditional Paneth cell-specific knockout of Atg16l1. This study demonstrates how explicit G+E can drive disease-relevant phenotype and provides rational strategies for identifying actionable targets.

DOI 10.1172/JCI120453
Citations Scopus - 1
2018 Kaiko GE, Wark PAB, 'Developments in cystic fibrosis personalised epithelial assays: Science and patient perspectives', JOURNAL OF CYSTIC FIBROSIS, 17 289-291 (2018)
DOI 10.1016/j.jcf.2018.03.012
Co-authors Peter Wark
2017 Foster PS, Maltby S, Rosenberg HF, Tay HL, Hogan SP, Collison AM, et al., 'Modeling T

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd In this review, we highlight experiments conducted in our laboratories that have elucidated functional... [more]

© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd In this review, we highlight experiments conducted in our laboratories that have elucidated functional roles for CD4+ T-helper type-2 lymphocytes (TH2 cells), their associated cytokines, and eosinophils in the regulation of hallmark features of allergic asthma. Notably, we consider the complexity of type-2 responses and studies that have explored integrated signaling among classical TH2 cytokines (IL-4, IL-5, and IL-13), which together with CCL11 (eotaxin-1) regulate critical aspects of eosinophil recruitment, allergic inflammation, and airway hyper-responsiveness (AHR). Among our most important findings, we have provided evidence that the initiation of TH2 responses is regulated by airway epithelial cell-derived factors, including TRAIL and MID1, which promote TH2 cell development via STAT6-dependent pathways. Further, we highlight studies demonstrating that microRNAs are key regulators of allergic inflammation and potential targets for anti-inflammatory therapy. On the background of TH2 inflammation, we have demonstrated that innate immune cells (notably, airway macrophages) play essential roles in the generation of steroid-resistant inflammation and AHR secondary to allergen- and pathogen-induced exacerbations. Our work clearly indicates that understanding the diversity and spatiotemporal role of the inflammatory response and its interactions with resident airway cells is critical to advancing knowledge on asthma pathogenesis and the development of new therapeutic approaches.

DOI 10.1111/imr.12549
Citations Scopus - 10Web of Science - 7
Co-authors Philip Hansbro, Hock Tay, Steven Maltby, Paul Foster, Nicole Hansbro, Ming Yang, Adam Collison, Joerg Mattes
2017 Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, et al., 'The microbial metabolite desaminotyrosine protects from influenza through type I interferon', Science, 357 498-502 (2017)

© 2017, American Association for the Advancement of Science. All rights reserved. The microbiota is known to modulate the host response to influenza infection through as-yet-uncle... [more]

© 2017, American Association for the Advancement of Science. All rights reserved. The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the microbiota exert effects through type I interferon (IFN), a hypothesis supported by analysis of influenza in a gain-of-function genetic mouse model. Here we show that a microbially associated metabolite, desaminotyrosine (DAT), protects from influenza through augmentation of type I IFN signaling and diminution of lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT and rescued antibiotic-treated influenza-infected mice. DAT protected the host by priming the amplification loop of type I IFN signaling. These findings show that specific components of the enteric microbiota have distal effects on responses to lethal infections through modulation of type I IFN.

DOI 10.1126/science.aam5336
Citations Scopus - 24
2017 Tay HL, 'Th22 Cells Form a Distinct Th Lineage from Th17 Cells In Vitro with Unique Transcriptional Properties and Tbet-Dependent Th1 Plasticity.', JOURNAL OF IMMUNOLOGY, 198 2182-2190 (2017) [C1]
DOI 10.4049/jimmunol.1601480
Citations Scopus - 9Web of Science - 9
Co-authors Steven Maltby, Paul Foster, Hock Tay
2016 Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, et al., 'The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites', Cell, 165 1708-1722 (2016) [C1]
DOI 10.1016/j.cell.2016.05.018
Citations Scopus - 85
2016 Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, et al., 'Erratum: The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites (Cell (2016) 165(7) (1708¿1720)(S0092867416305669)(10.1016/j.cell.2016.05.018))', Cell, 167 1137 (2016)

© 2016 (Cell 165, 1708¿1720; June 16, 2016) Our article investigated the effects of the metabolites produced by gut bacteria on intestinal stem cells and the role of intestinal mo... [more]

© 2016 (Cell 165, 1708¿1720; June 16, 2016) Our article investigated the effects of the metabolites produced by gut bacteria on intestinal stem cells and the role of intestinal morphology in mitigating those effects. Part of the study involved the generation of stem cells and colonocytes in¿vitro. In Figure¿S4, we characterized these stem cells and colonocytes with immunostaining. In the leftmost and middle images of panel C, we had intended to present micrographs from spheroids enriched in stem cells (leftmost) and in¿vitro differentiated colonocyte spheroids (middle) derived from colon tissue, as indicated in the original figure legend. However, we mistakenly presented micrographs of spheroids originally derived from small intestinal tissue. To correct the inconsistency introduced between the figure image panels and the legend, we now present below the figure in which the leftmost and middle images of panel C display our micrographs of a colon-derived stem cell spheroid (leftmost panel) and in¿vitro differentiated colonocyte spheroid (middle panel). The figure has been corrected online, and as the spheroids from both sources show similar polarity and localization of actin and ß-catenin, this change does not alter any of our conclusions.

DOI 10.1016/j.cell.2016.10.034
Citations Scopus - 11
2015 Hickey CA, Kuhn KA, Donermeyer DL, Porter NT, Jin C, Cameron EA, et al., 'Colitogenic Bacteroides thetaiotaomicron antigens access host immune cells in a sulfatase-dependent manner via outer membrane vesicles', Cell Host and Microbe, 17 672-680 (2015) [C1]

© 2015 Elsevier Inc. Microbes interact with the host immune system via several potential mechanisms. One essential step for each mechanism is the method by which intestinal microb... [more]

© 2015 Elsevier Inc. Microbes interact with the host immune system via several potential mechanisms. One essential step for each mechanism is the method by which intestinal microbes or their antigens access specific host immune cells. Using genetically susceptible mice (dnKO) that develop spontaneous, fulminant colitis, triggered by Bacteroides thetaiotaomicron (B. theta), we investigated the mechanism of intestinal microbial access under conditions that stimulate colonic inflammation. B. theta antigens localized to host immune cells through outer membrane vesicles (OMVs) that harbor bacterial sulfatase activity. We deleted the anaerobic sulfatase maturating enzyme (anSME) from B. theta, which is required for post-translational activation of all B. theta sulfatase enzymes. This bacterial mutant strain did not stimulate colitis in dnKO mice. Lastly, access of B. theta OMVs to host immune cells was sulfatase dependent. These data demonstrate that bacterial OMVs and associated enzymes promote inflammatory immune stimulation in genetically susceptible hosts.

DOI 10.1016/j.chom.2015.04.002
Citations Scopus - 40
2015 Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie A-T, et al., 'Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung.', PLoS pathogens, 11 e1004956 (2015) [O1]
DOI 10.1371/journal.ppat.1004956
Citations Scopus - 1
Co-authors Paul Foster, Ming Yang, Philip Hansbro, Joerg Mattes, Hock Tay, Steven Maltby
2015 Tay HL, Kaiko GE, Plank M, Li JJ, Maltby S, Essilfie AT, et al., 'Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung', PLoS Pathogens, 11 (2015) [C1]

© 2015 Tay et al. Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to ... [more]

© 2015 Tay et al. Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-microbial machinery of the innate immune system may boost host defence responses. Here we demonstrate that miR-328 is a key element of the host response to pulmonary infection with non-typeable haemophilus influenzae and pharmacological inhibition in mouse and human macrophages augments phagocytosis, the production of reactive oxygen species, and microbicidal activity. Moreover, inhibition of miR-328 in respiratory models of infection, steroid-induced immunosuppression, and smoke-induced emphysema enhances bacterial clearance. Thus, miRNA pathways can be targeted in the lung to enhance host defence against a clinically relevant microbial infection and offer a potential new anti-microbial approach for the treatment of respiratory diseases.

DOI 10.1371/journal.ppat.1004549
Citations Scopus - 26Web of Science - 29
Co-authors Ming Yang, Philip Hansbro, Steven Maltby, Paul Foster, Joerg Mattes, Hock Tay
2014 Kaiko GE, Stappenbeck TS, 'Host-microbe interactions shaping the gastrointestinal environment', Trends in Immunology, 35 538-548 (2014)

© 2014 Elsevier Ltd. Tremendous advances have been made in mapping the complexity of the human gut microbiota in both health and disease states. These analyses have revealed that,... [more]

© 2014 Elsevier Ltd. Tremendous advances have been made in mapping the complexity of the human gut microbiota in both health and disease states. These analyses have revealed that, rather than a constellation of individual species, a healthy microbiota comprises an interdependent network of microbes. The microbial and host interactions that shape both this network and the gastrointestinal environment are areas of intense investigation. Here we review emerg-ing concepts of how microbial metabolic processes con-trol commensal composition, invading pathogens, immune activation, and intestinal barrier function. We posit that all of these factors are critical for the mainte-nance of homeostasis and avoidance of overt inflamma- tory disease. A greater understanding of the underlying mechanisms will shed light on the pathogenesis of many diseases and guide new therapeutic interventions.

DOI 10.1016/j.it.2014.08.002
Citations Scopus - 49
2013 Kaiko G, Loh Z, Spann K, Lynch J, Lalwani A, Davidson S, et al., 'TLR7 gene deficiency and early-life pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Co-authors Paul Foster
2013 Kaiko GE, Loh Z, Spann K, Lynch JP, Lalwani A, Zheng Z, et al., 'Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 1331-U132 (2013) [C1]
DOI 10.1016/j.jaci.2013.02.041
Citations Scopus - 42Web of Science - 41
Co-authors Katherine Baines, Jodie Simpson, Paul Foster
2013 Foster PS, Plank MW, Collison AM, Tay HL, Kaiko GE, Li J, et al., 'The emerging role of microRNAs in regulating immune and inflammatory responses in the lung', Immunological Reviews, 253 198-215 (2013) [C1]
Citations Scopus - 56Web of Science - 58
Co-authors Ming Yang, Philip Hansbro, Hock Tay, Paul Foster, Joerg Mattes, Adam Collison
2013 Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
Citations Scopus - 40Web of Science - 37
Co-authors Jay Horvat, Malcolm Starkey, Ming Yang, Philip Hansbro, Paul Foster
2011 Kaiko GE, Foster PS, 'New insights into the generation of Th2 immunity and potential therapeutic targets for the treatment of asthma', Current Opinion in Allergy and Clinical Immunology, 11 39-45 (2011) [C1]
DOI 10.1097/aci.0b013e328342322f
Citations Scopus - 37Web of Science - 36
Co-authors Paul Foster
2011 Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 (2011) [C1]
DOI 10.1371/journal.ppat.1001339
Citations Scopus - 41Web of Science - 40
Co-authors Kelly Asquith, Paul Foster, Jay Horvat, Philip Hansbro
2011 Hansbro PM, Kaiko GE, Foster PS, 'Cytokine/anti-cytokine therapy - Novel treatments for asthma?', British Journal of Pharmacology, 163 81-95 (2011) [C2]
DOI 10.1111/j.1476-5381.2011.01219.x
Citations Scopus - 91Web of Science - 84
Co-authors Philip Hansbro, Paul Foster
2011 Davidson SK, Kaiko GE, Loh Z, Lalwani A, Zhang V, Spann K, et al., 'Plasmacytoid Dendritic Cells promote host defense against Acute Pneumovirus infection via the TLR7-MyD88-Dependent signaling pathway', Journal of Immunology, 186 5938-5948 (2011) [C1]
DOI 10.4049/jimmunol.1002635
Citations Scopus - 56Web of Science - 53
Co-authors Nicole Hansbro, Paul Foster
2010 Kaiko GE, Phipps S, Angkasekwinai P, Dong C, Foster PS, 'NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25', Journal of Immunology, 185 4681-4690 (2010) [C1]
DOI 10.4049/jimmunol.1001758
Citations Scopus - 85Web of Science - 83
Co-authors Paul Foster
2009 Phipps S, Lam CE, Kaiko GE, Foo A, Collison AM, Mattes J, et al., 'Toll/IL-1 signaling is critical for house dust mite-specific Th1 and Th2 responses', American Journal of Respiratory and Critical Care Medicine, 179 883-893 (2009) [C1]
DOI 10.1164/rccm.200806-974oc
Citations Scopus - 123Web of Science - 118
Co-authors Joerg Mattes, Adam Collison, Paul Foster
2008 Kaiko GE, Horvat JC, Beagley KW, Hansbro PM, 'Immunological decision-making: How does the immune system decide to mount a helper T-cell response?', Immunology, 123 326-338 (2008) [C1]
DOI 10.1111/j.1365-2567.2007.02719.x
Citations Scopus - 230Web of Science - 214
Co-authors Philip Hansbro, Jay Horvat
2008 Kaiko GE, Phipps S, Hickey DK, Lam CE, Hansbro PM, Foster PS, Beagley KW, 'Chlamydia muridarum infection subverts dendritic cell function to promote Th2 immunity and airways hyperreactivity', Journal of Immunology, 180 2225-2232 (2008) [C1]
Citations Scopus - 36Web of Science - 37
Co-authors Philip Hansbro, Paul Foster
2007 Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI 10.1164/rccm.200607-1005OC
Citations Scopus - 64Web of Science - 64
Co-authors Jay Horvat, Philip Hansbro, Nicole Hansbro, Peter Gibson, Paul Foster
Show 22 more journal articles

Conference (16 outputs)

Year Citation Altmetrics Link
2017 Tay HL, Hsu A, Nguyen T, Donovan C, Collison A, Mattes J, et al., 'Interleukin-36 gamma: Roles in lungs innate immunity, inflammation and allergy', CYTOKINE, Int Cytokine & Interferon Soc, Kanazawa, JAPAN (2017)
Co-authors Paul Foster, Chantal Donovan, Hock Tay, Philip Hansbro, Ming Yang, Joerg Mattes, Adam Collison, Alan Hsu
2017 Plank MW, Kaiko GE, Maltby S, Weaver J, Tay H, Shen W, et al., 'Th22 cells form a distinct th lineage from Th17 cells in vitro with unique transcriptional properties and Tbet-dependent Th1 plasticity', ALLERGY, Helsinki, FINLAND (2017)
Co-authors Steven Maltby, Paul Foster
2017 Plank MW, Kaiko GE, Maltby S, Weaver J, Tay H, Shen W, et al., 'TH22 CELLS FORM A DISTINCT TH LINEAGE FROM TH17 CELLS IN VITRO WITH UNIQUE TRANSCRIPTIONAL PROPERTIES AND TBET-DEPENDENT TH1 PLASTICITY DURING INFLUENZA INFECTION IN VIVO', RESPIROLOGY (2017)
Co-authors Paul Foster, Steven Maltby
2015 Tay H, Kaiko G, Plank M, Li J, Essilfie A, Maltby S, et al., 'THE ROLE OF MIR-328 IN RESPIRATORY DISEASES', RESPIROLOGY, Queensland, AUSTRALIA (2015) [E3]
Co-authors Paul Foster, Joerg Mattes, Steven Maltby, Philip Hansbro, Ming Yang
2015 Tay H, Kaiko G, Mattes J, Hansbro P, Foster P, 'The role of miR-328 in respiratory diseases', JOURNAL OF IMMUNOLOGY, New Orleans, LA (2015)
Co-authors Joerg Mattes, Paul Foster, Philip Hansbro
2013 Tay H, Kaiko G, Hansbro P, Foster P, 'The role of miRNA in regulating bacterial clearance', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Citations Web of Science - 1
Co-authors Paul Foster, Hock Tay, Philip Hansbro
2012 Kaiko GE, Tay HL, Plank MW, Hansbro PM, Foster PS, 'MicroRNA regulate bacterial phagocytosis in the lung', Immunology: Abstracts of the European Congress of Immunology, Glasgow, Scotland (2012) [E3]
Co-authors Paul Foster, Philip Hansbro
2012 Kaiko GE, Phipps S, Plank MW, Tay HL, Lam CE, Foster PS, 'Inhibition of microRNA reverses CD8 T cell exhaustion and improves immunity against respiratory virus infection', Respirology, Canberra, ACT (2012) [E3]
Co-authors Paul Foster, Hock Tay
2012 Plank MW, Kaiko GE, Luck H, Li J, Mattes J, Hansbro PM, Foster PS, 'The role of micrornas in CD4 T cell function', Respirology, Canberra, ACT (2012) [E3]
Co-authors Philip Hansbro, Joerg Mattes, Paul Foster
2012 Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, Foster PS, 'MiRNAs regulate bacterial infection in lungs', Respirology, Canberra, ACT (2012) [E3]
Co-authors Paul Foster, Philip Hansbro, Hock Tay, Joerg Mattes
2011 Foster PS, Tay HL, Kaiko GE, Plank MW, Mattes J, Hansbro PM, 'MiRNA and its roles in regulating bacterial infection in lungs', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Paul Foster, Joerg Mattes, Hock Tay, Philip Hansbro
2007 Phipps S, Lam CE, Kaiko GE, Collison A, Smith L, Mansell A, et al., 'Contribution of multiple toll-like receptors to the development of murine allergic airways inflammation', Immunology and Cell Biology, Manly, NSW (2007) [E3]
Co-authors Paul Foster
2007 Kaiko GE, Phipps S, Foster PS, 'Importance of CD4 T cells in the clearance of a primary Respiratory Syncytial Virus infection and in protection against the development of exhausted CD8 T cell memory', Immunology and Cell Biology, Manly, NSW (2007) [E3]
Co-authors Paul Foster
2007 Kaiko GE, Phipps S, Foster PS, 'Respiratory Syncytial Virus up-regulates PD-1 expression; comparison to a model of CD8 T cell exhaustion in BALB/c mice', Immuno 2007: 13th International Congress of Immunology, Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authors Paul Foster
2006 Kaiko GE, Phipps S, Lam CE, Hickey DK, Hansbro NG, Foster PS, Beagley KW, 'The chlamydia infection of dendritic cells drives the development of a pro-asthmatic response', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authors Paul Foster, Nicole Hansbro
2005 Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens, Melbourne, Australia (2005) [E3]
Citations Web of Science - 1
Co-authors Paul Foster, Jay Horvat, Philip Hansbro, Peter Gibson
Show 13 more conferences
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Grants and Funding

Summary

Number of grants 5
Total funding $1,546,013

Click on a grant title below to expand the full details for that specific grant.


20191 grants / $437,036

Investigation of the role of novel cell types and metabolites in the pathogenesis of asthma$437,036

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Gerard Kaiko
Scheme Career Development Fellowships
Role Lead
Funding Start 2019
Funding Finish 2022
GNo G1800379
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20181 grants / $821,399

Functional characterisation of novel metabolites in asthma and identification of new biomarkers $821,399

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Gerard Kaiko, Laureate Professor Paul Foster
Scheme Project Grant
Role Lead
Funding Start 2018
Funding Finish 2021
GNo G1700376
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20171 grants / $20,000

Precision medicine in Cystic Fibrosis: A personalised test to target individual mutations to specific CFTR modulators$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Gerard Kaiko, Conjoint Professor Peter Wark
Scheme Project Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1701536
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

20132 grants / $267,578

Investigating the interaction between susceptibility genes, viral infection, and gut microbiota in inflammation and epithelial repair processes$247,578

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Gerard Kaiko
Scheme Early Career Fellowships
Role Lead
Funding Start 2013
Funding Finish 2017
GNo G1100647
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Associate Professor Jay Horvat, Associate Professor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y
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Research Opportunities

Postdoctoral research positions available

Postdoctoral research positions available from 2019 to work on the role of adult stem cells in diseases of the lung (asthma and COPD) and gastrointestinal tract (IBD). This will include working with 3D model systems and patient-derived cells. Level A position. Research is based in the Priority Research Centre for Healthy Lungs at UON/HMRI.

Postdoctoral

Faculty Of Health

20/01/2019 - 31/01/2022

Contact

Doctor Gerard Kaiko
University of Newcastle
School of Biomedical Sciences and Pharmacy
gerard.kaiko@newcastle.edu.au

PhD scholarships to study adults stem cells in regenerative medicine OR study mechanisms of respiratory diseases

Study adults stem cells in regenerative medicine OR study mechanisms of respiratory diseases (asthma, COPD, cystic fibrosis).

PHD

Faculty of Health and Medicine

10/01/2018 - 10/01/2021

Contact

Doctor Gerard Kaiko
University of Newcastle
School of Biomedical Sciences and Pharmacy
gerard.kaiko@newcastle.edu.au

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News

Funding success to address chronic disease

August 16, 2018

Researchers from the University of Newcastle have received more than $5.8 million in NHMRC funding to tackle chronic disease.

Dr Gerard Kaiko

Position

Research Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Email gerard.kaiko@newcastle.edu.au
Phone (02) 40420184

Office

Building HMRI
Location Level 2 East Hunter Medical Research Institute (HMRI)

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