Dr Peter Pockney

Dr Peter Pockney

Conjoint Senior Lecturer

School of Medicine and Public Health (Medicine)

Career Summary

Biography

Dr Pockney is a Conjoint Senior Lecturer in Surgery at the University of Newcastle

Research Profile: https://scholar.google.com/citations?user=DtG9EG0AAAAJ&hl=en



Qualifications

  • Doctor of Medicine, University of Southampton - UK
  • Bachelor of Science (Honours)(Geography), University of Exeter - UK
  • Bachelor of Medicine, Bachelor of Surgery, University of London
  • Post Graduate Cert-Completion of Train(Gen Surgery, Post Graduate Medical Educ & Training Board - UK

Keywords

  • Clinical Trials
  • Colorectal Cancer
  • Colorectal Cancer Screening
  • Colorectal Surgery
  • FAP
  • Neutrophil Extracellular Traps

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer Priority Research Centre (PRC) for Healthy Lungs | The University of Newcastle
School of Medicine and Public Health
Australia
Senior Lecturer University of Newcastle
School of Medicine and Public Health
Australia

Professional appointment

Dates Title Organisation / Department
11/1/2011 - 21/7/2028 Consultant Surgeon

Consultant Colorectal and General Surgeon.

John Hunter Hospital, Newcastle
Colorectal Surgery
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2019 Gould T, Jamaluddin M, Petit J, King SJ, Nixon B, Scott R, et al., 'Finding Needles in Haystacks: The Use of Quantitative Proteomics for the Early Detection of Colorectal Cancer', Advances in the Molecular Understanding of Colorectal Cancer, IntechOpen, Switzerland 1-32 (2019) [B1]
DOI 10.5772/intechopen.80942
Co-authors Matt Dun, Rodney Scott, Brett Nixon, Muhammad Jamaluddin

Journal article (55 outputs)

Year Citation Altmetrics Link
2021 Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, et al., 'Elective cancer surgery in COVID-19 Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study', Journal of Clinical Oncology, 39 66-78 (2021) [C1]

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aim... [more]

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19¿free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19¿free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19¿free surgical pathways. Patients who underwent surgery within COVID-19¿free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19¿free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score¿matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19¿free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19¿free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.

DOI 10.1200/JCO.20.01933
Citations Scopus - 21Web of Science - 15
2021 Stephensen BD, Reid F, Shaikh S, Carroll RNR, Smith SR, Pockney P, PREDICT Study Group collaborators, 'Comment on: C-reactive protein trajectory to predict colorectal anastomotic leak: PREDICT Study by Plate et al.', Br J Surg, (2021)
DOI 10.1093/bjs/znab064
2021 Dudi-Venkata NN, Cox DRA, Marson N, Tan L, Pockney P, Muralidharan V, et al., 'Variation in Human Research Ethics Committee and governance processes throughout Australia: a need for a uniform approach.', ANZ J Surg, (2021)
DOI 10.1111/ans.16842
2021 Reid FSW, Egoroff N, Pockney PG, Smith SR, 'A systematic scoping review on natural killer cell function in colorectal cancer.', Cancer Immunol Immunother, 70 597-606 (2021)
DOI 10.1007/s00262-020-02721-6
Co-authors Stephen Smith
2021 Knight SR, Shaw CA, Pius R, Drake TM, Norman L, Ademuyiwa AO, et al., 'Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries', The Lancet, 397 387-397 (2021)

Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs)... [more]

Background: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70¿8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39¿8·80) and upper-middle-income countries (2·06, 1·11¿3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26¿11·59) and upper-middle-income countries (3·89, 2·08¿7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit.

DOI 10.1016/S0140-6736(21)00001-5
Citations Scopus - 1
Co-authors Jonathan Gani, Amanda Dawson, Stephen Smith
2021 Wilkin R, Coe P, Duarte R, Stott M, Pockney P, Egoroff N, et al., 'An international pragmatic randomized controlled trial to compare a single-use negative-pressure dressing versus the surgeon's preference of dressing to reduce the incidence of surgical site infection following emergency laparotomy: the SUNRRISE trial protocol', COLORECTAL DISEASE, 23 989-1000 (2021)
DOI 10.1111/codi.15474
2020 Whitcher S, Magnusson M, Gani J, Oldmeadow C, Pockney PG, 'Comparison of colonic neoplasia detection rates in patients screened inside and outside the National Bowel Cancer Screening Program', Medical Journal of Australia, 212 275-276 (2020) [C1]
DOI 10.5694/mja2.50508
Citations Web of Science - 1
Co-authors Jonathan Gani, Christopher Oldmeadow
2020 Peters LE, Zhao J, Martin J, Smith SR, Pockney P, 'Comment on "Opioids After Surgery in the United States Versus the Rest of the World: The International Patterns of Opioid Prescribing (iPOP) Multicenter Study".', Annals of surgery, Publish Ahead of Print (2020)
DOI 10.1097/sla.0000000000004568
Co-authors Stephen Smith, Jen Martin
2020 Stephensen BD, Reid F, Shaikh S, Carroll R, Smith SR, Pockney P, 'C-reactive protein trajectory to predict colorectal anastomotic leak: PREDICT Study', British Journal of Surgery, 107 1832-1837 (2020)
DOI 10.1002/bjs.11812
Citations Scopus - 4Web of Science - 3
Co-authors Stephen Smith
2020 Glasbey JC, Nepogodiev D, Omar O, Simoes JFF, Ademuyiwa A, Fiore M, et al., 'Delaying surgery for patients with a previous SARS-CoV-2 infection', British Journal of Surgery, 107 e601-e602 (2020)
DOI 10.1002/bjs.12050
Citations Scopus - 15
Co-authors Jonathan Gani
2020 Peters L, Zhao J, Makanyengo S, Pockney P, 'Delayed Splenic Artery Pseudoaneurysm After Laparoscopic Sleeve Gastrectomy', OBESITY SURGERY, 31 872-874 (2020)
DOI 10.1007/s11695-020-04914-5
2020 Fenton M, Gani J, Pockney P, 'Adverse Events After Inpatient Colonoscopy in Octogenarians: Patient Selection Key for Colonoscopies', JOURNAL OF CLINICAL GASTROENTEROLOGY, 54 484-484 (2020)
DOI 10.1097/MCG.0000000000001345
Co-authors Jonathan Gani
2020 Chapman SJ, Blanco-Colino R, Pérez-Ajates S, Bautista OA, Hodson J, Blanco-Colino R, et al., 'Safety of hospital discharge before return of bowel function after elective colorectal surgery', British Journal of Surgery, 107 552-559 (2020)

Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the... [more]

Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien¿Dindo classification system. Results: A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4¿7) and 7 (6¿8) days respectively (P < 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110). Conclusion: Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients.

DOI 10.1002/bjs.11422
Citations Scopus - 2
2020 Makanyengo SO, Carroll GM, Goggins BJ, Smith SR, Pockney PG, Keely S, 'Systematic Review on the Influence of Tissue Oxygenation on Gut Microbiota and Anastomotic Healing', JOURNAL OF SURGICAL RESEARCH, 249 186-196 (2020) [C1]
DOI 10.1016/j.jss.2019.12.022
Citations Scopus - 1Web of Science - 1
Co-authors Stephen Smith, Simon Keely, Bridie Goggins
2020 Almaadany FS, Samadov E, Namazov I, Jafarova S, Ramshorst GHV, Pattyn P, et al., 'Mortality and pulmonary complications in patients undergoing surgery with perioperative sars-cov-2 infection: An international cohort study', The Lancet, 396 27-38 (2020)

Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during an... [more]

Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (740%) had emergency surgery and 280 (248%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (261%) patients. 30-day mortality was 238% (268 of 1128). Pulmonary complications occurred in 577 (512%) of 1128 patients; 30-day mortality in these patients was 380% (219 of 577), accounting for 817% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 175 [95% CI 128-240], p<00001), age 70 years or older versus younger than 70 years (230 [165-322], p<00001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (235 [157-353], p<00001), malignant versus benign or obstetric diagnosis (155 [101-239], p=0046), emergency versus elective surgery (167 [106-263], p=0026), and major versus minor surgery (152 [101-231], p=0047). Interpretation Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research.

DOI 10.1016/S0140-6736(20)31182-X
Citations Scopus - 390
2020 Vavilov S, Smith G, Starkey M, Pockney P, Deshpande AV, 'Parental decision regret in childhood hypospadias surgery: A systematic review', Journal of Paediatrics and Child Health, 56 1514-1520 (2020) [C1]

We conducted a systematic review of the literature to establish the prevalence of and predictive factors for parental decision regret in hypospadias surgery. A search strategy wit... [more]

We conducted a systematic review of the literature to establish the prevalence of and predictive factors for parental decision regret in hypospadias surgery. A search strategy without language restrictions was developed with expert help, and two reviewers undertook independent study selection. Five studies were included in this review (four for quantitative analysis) with a total of 783 participants. The mean overall prevalence of parental decision regret was 65.2% (moderate to severe ¿ 20.3%). Although significant predictors of regret were identified (post-operative complications, small size glans, meatal location, decision conflict between parents, parental educational level and others), they had unexplained discordance between studies. Parental decision regret after proximal hypospadias surgery and refusing surgery was inadequately reported. In conclusion, even though the prevalence of parental decision regret after consenting for the hypospadias repair appears to be high, risk factors associated with it were discordant suggesting imprecision in estimates due to unknown confounders.

DOI 10.1111/jpc.15075
Co-authors Aniruddh Deshpande, Malcolm Starkey
2020 Chapman SJ, Clerc D, Blanco-Colino R, Otto A, Nepogodiev D, Pagano G, et al., 'Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery', British Journal of Surgery, 107 e161-e169 (2020)

Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-s... [more]

Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57¿75) years (54·9 per cent men). Some 1153 (27·7 per cent) received NSAIDs on postoperative days 1¿3, of whom 1061 (92·0 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4·6 versus 4·8 days; hazard ratio 1·04, 95 per cent c.i. 0·96 to 1·12; P = 0·360). There were no significant differences in anastomotic leak rate (5·4 versus 4·6 per cent; P = 0·349) or acute kidney injury (14·3 versus 13·8 per cent; P = 0·666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35·3 versus 56·7 per cent; P < 0·001). Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement.

DOI 10.1002/bjs.11326
Citations Scopus - 10
Co-authors Amanda Dawson
2020 Eliezer DD, Holmes M, Sullivan G, Gani J, Pockney P, Gould T, et al., 'High-Risk Emergency Laparotomy in Australia: Comparing NELA, P-POSSUM, and ACS-NSQIP Calculators', Journal of Surgical Research, 246 300-304 (2020) [C1]

Background: The National Emergency Laparotomy Audit (NELA) highlights the importance of identifying high-risk patients due to the potential for significant morbidity and mortality... [more]

Background: The National Emergency Laparotomy Audit (NELA) highlights the importance of identifying high-risk patients due to the potential for significant morbidity and mortality. The NELA risk prediction calculator (NRPC) was developed from data in England and Wales and is one of several calculators available. We seek to determine the utility of NRPC in the Australian population and compare it with Portsmouth Physiological and Operative Severity Score for the enumeration of mortality and Morbidity (P-POSSUM) and American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) calculators. Methods: A retrospective review of all emergency laparotomies undertaken at four Australian centers was performed between January 2016 and December 2017. Data extracted from patient records were used to calculate NRPC, ACS-NSQIP, and P-POSSUM scores for 30-day mortality risk. The sensitivity of NRPC was assessed using the NELA high-risk cohort score of =10% and this was compared with the other two calculators. Results: There were 562 (M = 261, mean age = 66 [±17] y) patient charts reviewed in the study period. 59 patients died within 30 d (10.5%). NRPC was able to identify 52 (sensitivity = 88.1%) of these as being within the high-risk group. Using the NELA high-risk cutoff, NRPC identified 52 deaths of 205 (25.4%) high-risk patients, P-POSSUM identified 46 of 245 (18.8%), and ACS-NSQIP identified 46 of 201 (22.9%). Using the McNemar test, no significant difference was noted between NRPC and P-POSSUM (P = 0.07) or NRPC and ACS-NSQIP (P = 0.18). Conclusions: In the Australian context, the NRPC is a highly sensitive and useful tool for predicting 30-day mortality in high-risk emergency laparotomy patients and is comparable with P-POSSUM and ACS-NSQIP calculators.

DOI 10.1016/j.jss.2019.09.024
Citations Scopus - 5Web of Science - 4
Co-authors Jonathan Gani
2020 Gani J, Pockney P, 'Comparison of colonic neoplasia detection rates in patients screened inside and outside the National Bowel Cancer Screening Program', MJA, (2020)
Co-authors Jonathan Gani
2020 Glasbey JC, Bibi S, Pata F, Ozkan BB, Van Straten S, Hodson J, et al., 'Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study', Colorectal Disease, 22 2288-2297 (2020)

Aim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim... [more]

Aim: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method: This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergoing elective colorectal surgery between January 2018 and April 2018 were eligible. Those receiving a NGT were divided into three groups, based on the timing of the insertion: routine NGT (inserted at the time of surgery), prophylactic NGT (inserted after surgery but before vomiting) and reactive NGT (inserted after surgery and after vomiting). The primary outcome was the development of pneumonia within 30¿days of surgery, which was compared between the prophylactic and reactive NGT groups using multivariable regression analysis. Results: A total of 4715 patients were included in the analysis and 1536 (32.6%) received a NGT. These were classified as routine in 926 (60.3%), reactive in 461 (30.0%) and prophylactic in 149 (9.7%). Two hundred patients (4.2%) developed pneumonia (no NGT 2.7%; routine NGT 5.2%; reactive NGT 10.6%; prophylactic NGT 11.4%). After adjustment for confounding factors, no significant difference in pneumonia rates was detected between the prophylactic and reactive NGT groups (odds ratio 1.03, 95% CI 0.56¿1.87, P¿=¿0.932). Conclusion: In patients who required the insertion of a NGT after surgery, prophylactic insertion was not associated with fewer cases of pneumonia within 30¿days of surgery compared with reactive insertion.

DOI 10.1111/codi.15311
Co-authors Amanda Dawson
2020 Carroll GM, Burns GL, Petit JA, Walker MM, Mathe A, Smith SR, et al., 'Does postoperative inflammation or sepsis generate neutrophil extracellular traps that influence colorectal cancer progression? A systematic review', Surgery Open Science, 2 57-69 (2020) [C1]
DOI 10.1016/j.sopen.2019.12.005
Co-authors Stephen Smith, Marjorie Walker, Andrea Johns, Simon Keely
2020 Watson DI, Tan L, Richards T, Muralidharan V, Pockney P, 'Trainee-led collaboratives, clinical trials and new opportunities in the COVID-19 era.', ANZ J Surg, 90 2175-2176 (2020)
DOI 10.1111/ans.16156
2020 Nepogodiev D, Omar OM, Glasbey JC, Li E, Simoes JFF, Abbott TEF, Ademuyiwa AO, 'Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans', British Journal of Surgery, 107 1440-1449 (2020)

Background: The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worl... [more]

Background: The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19. Methods: A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian ß-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations. Results: The best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption. Conclusion: A very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.

DOI 10.1002/bjs.11746
Citations Scopus - 258
2020 Zhao J, Peters L, Gelzinnis S, Carroll R, Nolan J, Di Sano S, et al., 'Post-discharge opioid prescribing after laparoscopic appendicectomy and cholecystectomy', ANZ JOURNAL OF SURGERY, 90 1014-1018 (2020) [C1]
DOI 10.1111/ans.15882
Citations Scopus - 1Web of Science - 1
Co-authors Stephen Smith
2019 Clarke L, Pockney P, Gillies D, Foster R, Gani J, 'Direct access colonoscopy service for bowel cancer screening produces a positive financial benefit for patients and local health districts', Internal Medicine Journal, 49 729-733 (2019) [C1]

Background: A direct access colonoscopy service (DACS) for the National Bowel Cancer Screening Program has become standard of care in Newcastle public hospitals because of the eff... [more]

Background: A direct access colonoscopy service (DACS) for the National Bowel Cancer Screening Program has become standard of care in Newcastle public hospitals because of the effect it has on time to colonoscopy. Cost-effectiveness has not been studied to date. Aim: The aim of this retrospective study was to analyse the cost-effectiveness of a DACS. Methods: Data were collected for patients referred to DACS between January 2014 and June 2016, and patients who were treated on the normal service pathway in 2013 prior to the introduction of the process. A cost-benefit analysis from the patient¿s and local health district¿s perspective was undertaken. Results: Introduction of the DACS produces a direct financial gain to patients in the form of reduced direct costs. It produces an indirect financial gain in terms of increased productivity if the patient is in work, and of increased leisure time if not in work. The DACS is modest income generating for the local health district, an evaluation which is sensitive to internal policies for distribution of government funding within a district. The DACS increases the availability of outpatient consultations to other patients, which is not a quantifiable economic benefit, but is likely to be an overall health benefit. Conclusion: The introduction of DACS in the public system in Australia is of financial benefit to patients and to the local health service provider. It is likely to produce health benefits to non-screening patients, by means of freeing consultations to be used for other indications.

DOI 10.1111/imj.14149
Citations Scopus - 2Web of Science - 2
Co-authors Jonathan Gani
2019 Clarke L, Pockney P, Gillies D, Foster R, Gani J, 'Time to colonoscopy for patients accessing the direct access colonoscopy service compared to the normal service in Newcastle, Australia', Internal Medicine Journal, 49 1132-1137 (2019) [C1]

Background: The 2017 National Bowel Cancer Screening Program report records a median time from positive faecal occult blood test to colonoscopy of 53 days. There is some intrinsic... [more]

Background: The 2017 National Bowel Cancer Screening Program report records a median time from positive faecal occult blood test to colonoscopy of 53 days. There is some intrinsic delay in accessing specialist medical opinion prior to colonoscopy. Aim: To examine the effect of the introduction of a Direct Access Colonoscopy Service (DACS). Methods: Using prospectively maintained databases, patients undergoing normal service (NS) colonoscopy and those referred to DACS were compared. The primary outcome measure was the time from general practitioner (GP) referral to colonoscopy. Secondary outcome measures included the proportion of patients who met the current recommended 30 days from GP referral to colonoscopy, and the proportion of patients who waited longer than 90 days. Results: There were 289 patients in the NS group, and 601 patients who progressed on the DACS pathway. The demographics of both groups were comparable. DACS patients had a median waiting time of 49 days, significantly shorter than NS patients whose median wait was 79 days (P < 0.0001). Approximately 15.1% patients in the DACS group had their colonoscopy within 30 days from GP referral, significantly better than in the NS group (4.5%, P < 0.001). In the NS group, 41.2% patients waited longer than 90 days from GP referral to colonoscopy, compared with 16.3% in the DACS group (P < 0.001). Conclusion: DACS reduces waiting times to colonoscopy and is associated with an increased proportion of patients undergoing colonoscopy in a timely manner.

DOI 10.1111/imj.14157
Citations Scopus - 2Web of Science - 2
Co-authors Jonathan Gani
2019 March B, Leigh L, Brussius-Coelho M, Holmes M, Pockney P, Gani J, 'Can CRP velocity in right iliac fossa pain identify patients for intervention? A prospective observational cohort study', Surgeon, 17 284-290 (2019) [C1]

Introduction: Previous studies have shown single CRP measurements at time of presentation to have limited predictive benefit for appendicitis. Our objective was to determine the d... [more]

Introduction: Previous studies have shown single CRP measurements at time of presentation to have limited predictive benefit for appendicitis. Our objective was to determine the diagnostic utility of serial CRP measurements (to determine CRP velocity [CRPv]) in patients with right iliac fossa (RIF) pain. Methods: A single-centre prospective observational study was conducted on adult patients admitted with RIF pain. CRP was measured on admission, at midnight, and the following morning. Appendicitis was diagnosed on histopathology, or diagnostic imaging in non-operatively managed patients. Therapeutic interventions included all appropriate operative procedures and effective non-operative treatment with antibiotics. Logistic regression was used to generate predictors of therapeutic intervention, and then used to create a new risk score incorporating CRPv. Results: 98 of 112 (87.5%) participants had complete CRP data. 58 patients met the criteria for appendicitis (59.2%). Most patients presented with intermediate Modified Alvarado Scores (MAS) 5¿6 (40.8%) or Appendicitis Inflammatory Response Scores (AIRS) 5¿8 (49%). Our risk score had an AUROC of 0.88 (95% CI 0.81¿0.96) in predicting therapeutic intervention. This score was superior to MAS, AIRS, and single admission biomarker measurements. Patients with an increasing CRPv had 14 times the odds (OR 14.07, 95% CI 0.63¿315.2) of complicated appendicitis, and no cases of complicated appendicitis were observed in patients with a flat CRPv. Conclusions: CRP velocity is superior to single CRP at predicting intervention. Our v-Score shows promise as a decision making-aide by predicting the need for surgical intervention in RIF pain. A flat CRPv identifies a group of patients with a very low risk of complicated appendicitis.

DOI 10.1016/j.surge.2018.08.007
Citations Scopus - 3Web of Science - 3
Co-authors Jonathan Gani
2019 Petit J, Carroll G, Gould T, Pockney P, Dun M, Scott RJ, 'Cell-free DNA as a Diagnostic Blood-Based Biomarker for Colorectal Cancer: A Systematic Review', Journal of Surgical Research, 236 184-197 (2019) [C1]

Background: Circulating tumour DNA (ctDNA) has emerged as an excellent candidate for the future of liquid biopsies for many cancers. There has been growing interest in blood-based... [more]

Background: Circulating tumour DNA (ctDNA) has emerged as an excellent candidate for the future of liquid biopsies for many cancers. There has been growing interest in blood-based liquid biopsy because of the potential of ctDNA to produce a noninvasive test that can be used for: the diagnosis of colorectal cancer, monitoring therapy response, and providing information on overall prognosis. The aim of this review was to collate and explore the current evidence regarding ctDNA as a screening tool for colorectal cancer (CRC). Methods: A systematic review of published articles in English over the past 20 y was performed using Medline, Embase, and Cochrane databases on May 23, 2017. After a full-text review, a total of 69 studies were included. Two assessment tools were used to review and compare the methodological quality of these studies. Results: Among the 69 studies included, 17 studies reviewed total cfDNA, whereas six studies looked at the DNA integrity index and 15 focused on ctDNA. There were a total of 40 studies that reviewed methylated cfDNA with 19 of these focussing specifically on SEPT9. Conclusions: The results of this review indicate that methylated epigenetic ctDNA markers are perhaps the most promising candidates for a blood-based CRC-screening modality using cell-free (cf) DNA. Methylated cfDNA appears to be less specific for CRC compared to ctDNA; however, they have demonstrated good sensitivity for early-stage CRC. Further research is required to determine which methylated cfDNA markers are the most accurate when applied to large cohorts of patients. In addition, reliable comparison of results across multiple studies would benefit from standardization of methodology for DNA extraction and PCR techniques in the future.

DOI 10.1016/j.jss.2018.11.029
Citations Scopus - 19Web of Science - 14
Co-authors Rodney Scott, Matt Dun
2018 Smith SR, Murray D, Pockney PG, Bendinelli C, Draganic BD, Carroll R, 'Tranexamic Acid for Lower GI Hemorrhage: A Randomized Placebo-Controlled Clinical Trial', Diseases of the Colon and Rectum, 61 99-106 (2018) [C1]

BACKGROUND: Lower GI hemorrhage is a common source of morbidity and mortality. Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clin... [more]

BACKGROUND: Lower GI hemorrhage is a common source of morbidity and mortality. Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clinical conditions. Information regarding the use of tranexamic acid in treating lower GI hemorrhage is lacking. OBJECTIVE: The aim of this trial was to determine the clinical efficacy of tranexamic acid when used for lower GI hemorrhage. DESIGN: This was a prospective, double-blind, placebo-controlled, randomized clinical trial. SETTINGS: The study was conducted at a tertiary referral university hospital in Australia. PATIENTS: Consecutive patients aged >18 years with lower GI hemorrhage requiring hospital admission from November 2011 to January 2014 were screened for trial eligibility (N = 265). INTERVENTIONS: A total of 100 patients were recruited after exclusions and were randomly assigned 1:1 to either tranexamic acid or placebo. MAIN OUTCOME MEASURES: The primary outcome was blood loss as determined by reduction in hemoglobin levels. The secondary outcomes were transfusion rates, transfusion volume, intervention rates for bleeding, length of hospital stay, readmission, and complication rates. RESULTS: There was no difference between groups with respect to hemoglobin drop (11 g/L of tranexamic acid vs 13 g/L of placebo; p = 0.9445). There was no difference with respect to transfusion rates (14/49 tranexamic acid vs 16/47 placebo; p = 0.661), mean transfusion volume (1.27 vs 1.93 units; p = 0.355), intervention rates (7/49 vs 13/47; p = 0.134), length of hospital stay (4.67 vs 4.74 d; p = 0.934), readmission, or complication rates. No complications occurred as a direct result of tranexamic acid use. LIMITATIONS: A larger multicenter trial may be required to determine whether there are more subtle advantages with tranexamic acid use in some of the secondary outcomes. CONCLUSIONS: Tranexamic acid does not appear to decrease blood loss or improve clinical outcomes in patients presenting with lower GI hemorrhage in the context of this trial. see Video Abstract at http://links.lww.com/DCR/A453.

DOI 10.1097/DCR.0000000000000943
Citations Scopus - 8Web of Science - 9
Co-authors Cino Bendinelli, Stephen Smith
2018 Almazi JG, Pockney P, Gedye C, Smith ND, Hondermarck H, Verrills NM, Dun MD, 'Cell-Free DNA Blood Collection Tubes Are Appropriate for Clinical Proteomics: A Demonstration in Colorectal Cancer.', Proteomics. Clinical applications, 12 e1700121 (2018) [C1]
DOI 10.1002/prca.201700121
Co-authors Hubert Hondermarck, Craig Gedye, Matt Dun, Nikki Verrills
2018 Smith SR, Pockney P, Holmes R, Doig F, Attia J, Holliday E, et al., 'Biomarkers and anastomotic leakage in colorectal surgery: C-reactive protein trajectory is the gold standard.', ANZ journal of surgery, 88 440-444 (2018) [C1]
DOI 10.1111/ans.13937
Citations Scopus - 18Web of Science - 18
Co-authors Stephen Smith, John Attia, Liz Holliday
2018 Holmes R, Smith SR, Carroll R, Holz P, Mehrotra R, Pockney P, 'Randomized clinical trial to assess the ideal mode of delivery for local anaesthetic abdominal wall blocks.', ANZ journal of surgery, 88 786-791 (2018) [C1]
DOI 10.1111/ans.14317
Citations Scopus - 3Web of Science - 5
Co-authors Stephen Smith
2018 Smith SR, Holmes R, Pockney P, Holz P, Carroll R, Mehrotra R, 'Response to Re: Randomized clinical trial to assess the ideal mode of delivery for local anaesthetic abdominal wall blocks', ANZ JOURNAL OF SURGERY, 88 805-806 (2018)
DOI 10.1111/ans.14766
Citations Scopus - 1
Co-authors Stephen Smith
2018 Holmes M, Connor T, Oldmeadow C, Pockney PG, Scott RJ, Talseth-Palmer BA, 'CD36-a plausible modifier of disease phenotype in familial adenomatous polyposis', HEREDITARY CANCER IN CLINICAL PRACTICE, 16 (2018) [C1]
DOI 10.1186/s13053-018-0096-y
Citations Scopus - 2Web of Science - 2
Co-authors Rodney Scott, Bente Talseth-Palmer, Christopher Oldmeadow
2017 Penna M, Hompes R, Arnold S, Wynn G, Austin R, Warusavitarne J, et al., 'Transanal Total Mesorectal Excision: International Registry Results of the First 720 Cases', Annals of Surgery, 266 111-117 (2017) [C1]

Objective: This study aims to report short-term clinical and oncological outcomes from the international transanal Total Mesorectal Excision (taTME) registry for benign and malign... [more]

Objective: This study aims to report short-term clinical and oncological outcomes from the international transanal Total Mesorectal Excision (taTME) registry for benign and malignant rectal pathology. Background: TaTME is the latest minimally invasive transanal technique pioneered to facilitate difficult pelvic dissections. Outcomes have been published from small cohorts, but larger series can further assess the safety and efficacy of taTME in the wider surgical population. Methods: Data were analyzed from 66 registered units in 23 countries. The primary endpoint was "good-quality TME surgery." Secondary endpoints were short-term adverse events. Univariate and multivariate regression analyses were used to identify independent predictors of poor specimen outcome. Results: A total of 720 consecutively registered cases were analyzed comprising 634 patients with rectal cancer and 86 with benign pathology. Approximately, 67% were males with mean BMI 26.5 kg/m 2. Abdominal or perineal conversion was 6.3% and 2.8%, respectively. Intact TME specimens were achieved in 85%, with minor defects in 11% and major defects in 4%. R1 resection rate was 2.7%. Postoperative mortality and morbidity were 0.5% and 32.6% respectively. Risk factors for poor specimen outcome (suboptimal TME specimen, perforation, and/or R1 resection) on multivariate analysis were positive CRM on staging MRI, low rectal tumor <2 cm from anorectal junction, and laparoscopic transabdominal posterior dissection to <4 cm from anal verge. Conclusions: TaTME appears to be an oncologically safe and effective technique for distal mesorectal dissection with acceptable short-term patient outcomes and good specimen quality. Ongoing structured training and the upcoming randomized controlled trials are needed to assess the technique further.

DOI 10.1097/SLA.0000000000001948
Citations Scopus - 202Web of Science - 207
Co-authors Stephen Smith
2017 Schmiegel W, Scott RJ, Dooley S, Lewis W, Meldrum CJ, Pockney P, et al., 'Blood-based detection of RAS mutations to guide anti-EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue-based RAS testing', MOLECULAR ONCOLOGY, 11 208-219 (2017) [C1]
DOI 10.1002/1878-0261.12023
Citations Scopus - 61Web of Science - 62
Co-authors Stephen Smith, Rodney Scott
2017 Zala A, Bollipo SJ, Pockney P, Foster R, 'Endoscopic Removal of a Large Kitchen Knife', GASTROINTESTINAL ENDOSCOPY, 85 AB126-AB126 (2017)
DOI 10.1016/j.gie.2017.03.210
2017 'Abstract Journal General Surgery', ANZ Journal of Surgery, 87 41-60 (2017)
DOI 10.1111/ans.13993
2015 Smith S, Pockney P, Attia J, 'Corrigendum: A Meta-analysis on the Effect of Sham Feeding Following Colectomy: Should Gum Chewing Be Included in Enhanced Recovery After Surgery Protocols?', Diseases of the colon and rectum, 58 e416 (2015) [O1]
DOI 10.1097/dcr.0000000000000407
Citations Scopus - 1
Co-authors Stephen Smith, John Attia
2015 Smith SR, Draganic B, Pockney P, Holz P, Holmes R, Mcmanus B, Carroll R, 'Transversus abdominis plane blockade in laparoscopic colorectal surgery: a double-blind randomized clinical trial', INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 30 1237-1245 (2015) [C1]
DOI 10.1007/s00384-015-2286-7
Citations Scopus - 25Web of Science - 27
Co-authors Stephen Smith
2015 'Abstract Journal for General Surgery', ANZ Journal of Surgery, 85 43-59 (2015)
DOI 10.1111/ans.13084
2015 'Abstract Journal for Pain Medicine (RACS)', ANZ Journal of Surgery, 85 93-94 (2015)
DOI 10.1111/ans.13093
2014 Ho YM, Smith SR, Pockney P, Lim P, Attia J, 'A Meta-analysis on the Effect of Sham Feeding Following Colectomy: Should Gum Chewing Be Included in Enhanced Recovery After Surgery Protocols?', DISEASES OF THE COLON & RECTUM, 57 115-126 (2014) [C1]
DOI 10.1097/DCR.0b013e3182a665be
Citations Scopus - 32Web of Science - 28
Co-authors John Attia, Stephen Smith
2014 'Colorectal Surgery Program Abstracts', ANZ Journal of Surgery, 84 30-52 (2014)
DOI 10.1111/ans.12609
2014 'The Six Best Abstracts', Colorectal Disease, 16 1-2 (2014)
DOI 10.1111/codi.12638
2010 Reid K, Pockney PG, Pollitt T, Draganic B, Smith SR, 'Randomized clinical trial of short-term outcomes following purse-string versus conventional closure of ileostomy wounds', British Journal of Surgery, 97 1511-1517 (2010) [C1]
DOI 10.1002/bjs.7151
Citations Scopus - 51Web of Science - 45
Co-authors Stephen Smith
2010 Reid K, Pockney P, Draganic B, Smith S, 'Barrier wound protection decreases surgical site infection in open elective colorectal surgery: A randomized clinical trial', Diseases of the Colon & Rectum, 53 1374-1380 (2010) [C1]
DOI 10.1007/DCR.0b013e3181ed3f7e
Citations Scopus - 69Web of Science - 63
Co-authors Stephen Smith
2009 Pockney PG, Primrose J, George S, Jayatilleke N, Leppard B, Smith H, et al., 'Recognition of skin malignancy by general practitioners: Observational study using data from a population-based randomised controlled trial', British Journal of Cancer, 100 24-27 (2009) [C1]
DOI 10.1038/sj.bjc.6604810
Citations Scopus - 18Web of Science - 17
2008 George S, Pockney PG, Primrose J, Smith H, Little P, Kinley H, et al., 'A prospective randomised comparison of minor surgery in primary and secondary care. The MISTIC trial', Health Technology Assessment, 12 1-30 (2008) [C1]
DOI 10.3310/hta12230
Citations Scopus - 32
2008 George S, Pockney P, Primrose J, Smith H, Little P, Kinley H, et al., 'A prospective randomised comparison of minor surgery in primary and secondary care. The MiSTIC trial', HEALTH TECHNOLOGY ASSESSMENT, 12 III-+ (2008)
Citations Web of Science - 27
2004 Pockney P, George S, Primrose J, Smith H, Kinley H, Little P, et al., 'Impact of the introduction of fee for service payments on types of minor surgical procedures undertaken by general practitioners: observational study', JOURNAL OF PUBLIC HEALTH, 26 264-267 (2004)
DOI 10.1093/pubmed/fdh152
Citations Scopus - 3Web of Science - 4
2002 Smith GB, Nolan J, King A, Pockney P, Nielsen M, Coombes M, et al., 'Medical emergency teams and cardiac arrests in hospital [3] (multiple letters)', British Medical Journal, 324 1215-1216 (2002)
Citations Scopus - 4
2002 King A, Pockney P, Nielsen M, Coombes M, Bailey I, Clancy M, 'Medical emergency teams and cardiac arrests in hospital. Bottom up approach works too.', BMJ (Clinical research ed.), 324 (2002)
Citations Scopus - 1
2002 Smith GB, Nolan J, 'Medical emergency teams and cardiac arrests in hospital - Results may have been due to education of ward staff', BRITISH MEDICAL JOURNAL, 324 1215-1215 (2002)
Citations Scopus - 9Web of Science - 11
1998 Clancy MJ, Pockney PG, 'Fitness to drive', JOURNAL OF ACCIDENT & EMERGENCY MEDICINE, 15 366-366 (1998)
Show 52 more journal articles

Conference (9 outputs)

Year Citation Altmetrics Link
2020 Petit J, Carroll G, Zhao J, Roper E, Pockney P, Scott R, 'Combined epigenetic methylation biomarker panel for the detection of colorectal cancer', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2020)
Co-authors Rodney Scott
2020 Thirugnanasundralingam V, Stieler M, Campbell C, Pockney P, Shah K, Spitta M, 'Somatic Symptom Disorder (SSD) and Abdominal Pain: Prevalence, Diagnostic Accuracy, Co-Morbidity and Relationship to Opioid Prescribing', BRITISH JOURNAL OF SURGERY, Glasgow, SCOTLAND (2020)
2018 Petit J, Pockney P, Scott R, 'Methylation Specific Droplet Digital PCR Accurately Quantifies BCAT1 Allele in Colorectal Cancer Patients', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)
Citations Web of Science - 3
Co-authors Rodney Scott
2018 Gould T, Jamaluddin MFB, Pockney P, Dun M, 'Quantitative Proteomics for the Early Detection of Colorectal Cancer', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)
Co-authors Muhammad Jamaluddin, Matt Dun
2016 Al Mazi JT, Verrills N, Smith N, Pockney P, Hondermarck H, Dun M, 'A COMPARISON BETWEEN DATA-DEPENDENT ANALYSIS AND HIGH-RESOLUTION ACCURATE MASS TARGETED PROTEOMICS APPROACHES FOR THE QUANTIFICATION OF PLASMA BIOMARKERS IN COLORECTAL CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2016)
Co-authors Matt Dun, Hubert Hondermarck
2015 Scott R, Dooley S, Lewis W, Meldrum C, Pockney P, Draganic B, et al., 'Concordance of RAS mutation status in CRC patients by comparison of results from circulating tumour DNA and tissue-based testing', ANNALS OF ONCOLOGY, Barcelona, SPAIN (2015) [E3]
DOI 10.1093/annonc/mdv233.270
Co-authors Stephen Smith, Rodney Scott
2014 Gillies D, Gani J, Foster R, Pockney P, Duggan A, 'FAST TRACK COLONOSCOPY FOR POSITIVE FAECAL OCCULT BLOOD TESTING ( plus FOBT) IN A PUBLIC HOSPITAL SETTING', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014)
Co-authors Jonathan Gani
2013 Grice DM, Bauer DC, Duesing K, Li D, Greenfield P, Nielsen S, et al., 'Human and microbial transcriptomics from lean and obese individuals with colorectal cancer: A comparison of Total and Poly A RNA sequencing from clinical samples.', CANCER RESEARCH, Washington, DC (2013) [E3]
DOI 10.1158/1538-7445.AM2013-LB-237
Co-authors Rodney Scott, Stephen Smith
2003 King AT, Pockney PG, Clancy MJ, Moore BA, Bailey IS, 'An Early Warning System reliably identifies high-risk surgical ward patients early in their clinical deterioration', BRITISH JOURNAL OF ANAESTHESIA, LONDON, ENGLAND (2003)
Citations Web of Science - 1
Show 6 more conferences
Edit

Grants and Funding

Summary

Number of grants 29
Total funding $3,126,766

Click on a grant title below to expand the full details for that specific grant.


20211 grants / $286,439

20201 grants / $23,750

Gut-Brain interactions in the development of Necrotising Enterocolitis$23,750

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Bridie Goggins, Doctor Julia Shaw, Professor Simon Keely, Doctor Aniruddh Deshpande, Doctor Peter Pockney
Scheme Project Grant
Role Investigator
Funding Start 2020
Funding Finish 2020
GNo G2000806
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

20199 grants / $1,545,723

Sunrrise Australia - A randomised clinical trial of Single Use Negative pRessure dressing for Reduction In Surgical site infection following Emergency laparotomy$783,718

Funding body: Department of Health

Funding body Department of Health
Project Team Doctor Peter Pockney, David Watson, Prof Toby Richards, Vijayaragavan Muralidharan, Tarik Sammour, Associate Professor Tarik Sammour, Hossein Haji Ali Afzali, Dr Bree Stephensen, Associate Professor Amanda Dawson, Dr Thomas Arthur
Scheme MRFF International Clinical Trial Collaborations
Role Lead
Funding Start 2019
Funding Finish 2021
GNo G1900263
Type Of Funding C1300 - Aust Competitive - Medical Research Future Fund
Category 1300
UON Y

Testing the impact of an Interactive Health Communication Application on days alive out of hospital and quality of life following surgery for colorectal cancer$306,710

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Steve Smith, Laureate Professor Robert Sanson-Fisher, Dr Jon Gani, Conjoint Professor Jonathan Gani, Professor Mariko Carey, Sancha Robinson, Doctor Sancha Robinson, Conjoint Professor Andrew Searles, Professor Andrew Searles, Doctor Peter Pockney, Doctor Christopher Oldmeadow, Mr Chris Oldmeadow, Conjoint Associate Professor Ross Kerridge
Scheme Partnership Projects
Role Investigator
Funding Start 2019
Funding Finish 2025
GNo G1800929
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure Funding Cancer Program 2019$275,294

Funding body: NSW Ministry of Health

Funding body NSW Ministry of Health
Project Team Conjoint Professor Stephen Ackland, Professor Xu Dong Zhang, Laureate Professor Rodney Scott, Associate Professor Nikki Verrills, Doctor Peter Pockney, Doctor Steve Smith, Doctor Liz Fradgley, Professor Amanda Baker, Doctor Jude Weidenhofer, Conjoint Professor Stephen Ackland
Scheme Medical Research Support Program (MRSP)
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1900048
Type Of Funding C2220 - Aust StateTerritoryLocal - Other
Category 2220
UON Y

A Double-Blind Randomised Placebo-Controlled Trial Assessing the Effect of Peri-Operative Intravenous Lignocaine and Post-Operative Lignocaine Neurovascular Plane Infusion on Natural Killer Ce$60,000

Funding body: Colorectal Surgical Society of Australia and New Zealand Foundation Pty Ltd

Funding body Colorectal Surgical Society of Australia and New Zealand Foundation Pty Ltd
Project Team Doctor Steve Smith, Professor Simon Keely, Conjoint Professor Jonathan Gani, Doctor Gang Liu, Doctor Peter Pockney
Scheme Research Grant
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1901026
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

Hide and Seek with hereditary cancer: Improving detection of colorectal cancer patients with a high risk of Lynch Syndrome$43,688

Funding body: Cancer Council NSW

Funding body Cancer Council NSW
Project Team Doctor Peter Pockney
Scheme Research Grant
Role Lead
Funding Start 2019
Funding Finish 2020
GNo G1801224
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON Y

MULTICENTRE COLORECTAL CANCER GENETIC BIOMARKER DISCOVERY PROJECT$27,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Dr JOEL Petit, Doctor Peter Pockney, Laureate Professor Rodney Scott
Scheme Research Grant
Role Investigator
Funding Start 2019
Funding Finish 2020
GNo G1901572
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Lignocaine infusion in Colerectal cancer Patient Immune Cells LICPIC Study$20,063

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Peter Pockney
Scheme Research Grant
Role Lead
Funding Start 2019
Funding Finish 2019
GNo G1900371
Type Of Funding C2220 - Aust StateTerritoryLocal - Other
Category 2220
UON Y

A new diagnostic test for prostate cancer$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Mr Brayden March, Doctor Sam Faulkner, Doctor Jude Weidenhofer, Doctor Peter Pockney
Scheme Research Grant
Role Investigator
Funding Start 2019
Funding Finish 2020
GNo G1901603
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

The Microbiome of Surgical Site Infections$14,250

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Simon Keely, Doctor Steve Smith, Doctor Peter Pockney
Scheme Project Grant
Role Investigator
Funding Start 2019
Funding Finish 2019
GNo G1901238
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

20188 grants / $787,778

HMRI MRSP Infrastructure Funding Cancer Program 2018$365,173

Funding body: NSW Ministry of Health

Funding body NSW Ministry of Health
Project Team Conjoint Professor Stephen Ackland, Professor Xu Dong Zhang, Laureate Professor Rodney Scott, Associate Professor Nikki Verrills, Doctor Peter Pockney, Doctor James Lynam, Professor Christine Paul, Professor Amanda Baker
Scheme Medical Research Support Program (MRSP)
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo G1800336
Type Of Funding C2220 - Aust StateTerritoryLocal - Other
Category 2220
UON Y

The role of microbial oxygen sensing in the development of anastomotic leaks$121,525

Funding body: Fisher & Paykel Healthcare Limited

Funding body Fisher & Paykel Healthcare Limited
Project Team Professor Simon Keely, Doctor Peter Pockney, Doctor Steve Smith
Scheme Research Consultancy
Role Investigator
Funding Start 2018
Funding Finish 2019
GNo G1701624
Type Of Funding C3211 - International For profit
Category 3211
UON Y

Mary Sawyer Postgraduate Scholarship in Cancer Research$99,750

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Dr Georgia Carroll, Professor Simon Keely, Doctor Peter Pockney, Professor Marjorie Walker, Doctor Steve Smith, Doctor Andrea Johns
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2018
Funding Finish 2021
GNo G1800612
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Investigation of disease markers in asymptomatic patients with colorectal carcinoma or colonic adenomas$81,337

Funding body: Streck

Funding body Streck
Project Team Associate Professor Matt Dun, Doctor Peter Pockney, Laureate Professor Rodney Scott
Scheme Research Grant
Role Investigator
Funding Start 2018
Funding Finish 2019
GNo G1800707
Type Of Funding C3211 - International For profit
Category 3211
UON Y

Lignocaine Infusion in Colorectal Cancer Patient Immune Cells LICPIC Study$59,993

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Doctor Steve Smith, Doctor Peter Pockney
Scheme Research Funding
Role Investigator
Funding Start 2018
Funding Finish 2019
GNo G1801298
Type Of Funding C2220 - Aust StateTerritoryLocal - Other
Category 2220
UON Y

Analysis of luminal bacteria at the site of colorectal anastomoses and their association with anastomotic leaks$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Simon Keely, Doctor Peter Pockney, Doctor Steve Smith, Associate Professor Ian Grainge, Doctor Andrea Johns
Scheme Project Grant
Role Investigator
Funding Start 2018
Funding Finish 2018
GNo G1701630
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

A novel minimally invasive assay to identify patients with bowel cancer$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Peter Pockney, Laureate Professor Rodney Scott
Scheme Project Grant
Role Lead
Funding Start 2018
Funding Finish 2018
GNo G1800199
Type Of Funding C3120 - Aust Philanthropy
Category 3120
UON Y

Proteo Genomics for Screening Bowel Cancer$20,000

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Doctor Peter Pockney, Laureate Professor Rodney Scott
Scheme Research Funding
Role Lead
Funding Start 2018
Funding Finish 2020
GNo G1801085
Type Of Funding C2220 - Aust StateTerritoryLocal - Other
Category 2220
UON Y

20173 grants / $201,000

Improving access to colonoscopy by targeted waitlist management$141,000

A grant to examine waitlists for colonoscopy in public hospitals in Newcastle to look for concordance or otherwise with National Guidelines in the indication for colonoscopy.  Using the data extracted, a pragmatic proposal for ensuring closer adherence to guidelines to ensure appropriate use of public resources will be devised

Funding body: Cancer Institute of NSW

Funding body Cancer Institute of NSW
Project Team

C/Professor Jon Gani, C A/Prof Tony Proietto, Dr R Foster, Ms D Gillies, Mrs J Lack

Scheme Innovations in Cancer Control Grants
Role Lead
Funding Start 2017
Funding Finish 2018
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

HCRA Infrastructure Funding$40,000

Funding body: Hunter Cancer Research Alliance (HCRA)

Funding body Hunter Cancer Research Alliance (HCRA)
Scheme ....
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding External
Category EXTE
UON N

The Impact of Surgery, Inflammation and Sepsis on Neutrophil Extracellular Trap (NET) Formation and Subsequent Metastatic Disease in Colorectal Cancer$20,000

Funding body: John Hunter Charitable Trust Grant

Funding body John Hunter Charitable Trust Grant
Scheme John Hunter Charitable Trust Grant
Role Lead
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding External
Category EXTE
UON N

20162 grants / $111,200

Improving Access to Colonoscopy for Diagnosis of Symptomatic Patients at High Risk of Colorectal Cancer (CRD) in HNE LHD$90,000

Funding body: Cancer Instititue NSW

Funding body Cancer Instititue NSW
Scheme Innovation Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding External
Category EXTE
UON N

A Propective Observational Study of CRP Velocity in Suspected Acute Appendicitis$21,200

Funding body: John Hunter Charitable Trust Grant

Funding body John Hunter Charitable Trust Grant
Scheme John Hunter Charitable Trust Grant
Role Lead
Funding Start 2016
Funding Finish 2016
GNo
Type Of Funding External
Category EXTE
UON N

20133 grants / $120,876

Introduction of Streamlined Access Pathways for Potential Colorectal Cancer Cases in the Lower Hunter$50,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Scheme Evidence to Practice Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo
Type Of Funding External
Category EXTE
UON N

Providing tailored web-based information to support colorectal cancer patients in their preparation for and recovery from surgery: A feasibility study$48,656

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Laureate Professor Robert Sanson-Fisher, Doctor Steve Smith, Doctor Sancha Robinson, Ms Gill Batt, Conjoint Professor Frans Henskens, Conjoint Associate Professor Ross Kerridge, Doctor Christopher Oldmeadow, Doctor Peter Pockney, Doctor Christopher Hayes
Scheme Evidence to Practice Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300868
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

A Phase 3 Randomised, Double Blind, Placebo Controlled Pragmatic Trial to Assess the Efficacy of Tranexamic Acid in Reducing the Blood Loss in Patients with Per Rectal Bleeding$22,220

Funding body: John Hunter Charitable Trust Grant

Funding body John Hunter Charitable Trust Grant
Scheme John Hunter Charitable Trust Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo
Type Of Funding External
Category EXTE
UON N

20121 grants / $20,000

Standardisation of Operative Equipment and Techniques for Common Acute General Surgery Operations$20,000

Funding body: Hunter New England LHD, NSW Health

Funding body Hunter New England LHD, NSW Health
Scheme Innovation Support Scholarship
Role Lead
Funding Start 2012
Funding Finish 2012
GNo
Type Of Funding External
Category EXTE
UON N

20111 grants / $30,000

Donation to Support CNC GI Clinical Research Position$30,000

Funding body: Hunter New England LHD, NSW Health

Funding body Hunter New England LHD, NSW Health
Scheme Division of Surgery
Role Lead
Funding Start 2011
Funding Finish 2011
GNo
Type Of Funding External
Category EXTE
UON N
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Research Supervision

Number of supervisions

Completed5
Current10

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2021 PhD Somatic Symptom Disorder and Undifferentiated Abdominal Pain; Prevalence, Diagnostic Accuracy and Comorbidity PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle Principal Supervisor
2021 PhD Over-Prescription of Opioid Analgesics on Discharge after Common General Surgical Procedures PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
2021 PhD The Role of Microbial Oxygen Sensing in the Development of Anastomotic Leaks PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
2020 PhD ProNGF as a Urinary Biomarker for Prostate Cancer? PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
2019 PhD Childhood Hypospadias: Evaluating the Long-Term Outcomes and Revisiting the Ideal Model of Care. PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
2018 PhD The Introduction of an Emergency Laparotomy Audit in Australia PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle Principal Supervisor
2018 PhD The Functional Effects of CD36 Polymorphisms in Colorectal Cancer PhD (Medical Genetics), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
2018 PhD Microbiome of Surgical Site PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
2017 PhD Circulating Tumour DNA as a Novel Biomarker for Colorectal Cancer PhD (Medical Genetics), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor
2017 PhD The Impact of Surgery, Inflammation and Sepsis on Neutrophil Extracellular Trap (NET) Formation and Subsequent Metastatic Disease in Colorectal Cancer PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2018 Masters Morbidity and Mortality of Colonoscopies in the Hunter New England Region
Masters degree in Surgical Sciences by distance learning, final year consists of a supervised research program leading through project design, interim reports and progress poster presentation to a final thesis submitted for assessment
Surgery, University of Edinburgh Principal Supervisor
2016 Masters A Potential Modifier Gene in Familial Adenosis Polyposis
This was a project that examined the genes of patients with FAP looking for evidence of modifier genes that affect the age of onset of polyposis and of developing cancer in patients with FAP.
Genetics, University of Edinburgh Co-Supervisor
2014 Masters Haemorhoid Goligher grade versus symptom severity
This was a pilot study of the correlation of patient reported symptoms compared to surgeon assessed clinical severity.
Surgery, The University of Sydney Principal Supervisor
2014 Honours Development of a Novel CO2 Insulflation Device for Laparotomy
This was an honours student project that developed a device that provided a constant infusion of CO2 to the wound edge in an animal model of a laparotomy wound, with the long term aim of developing a device that can reduce the incidence of aerobic infections in surgical wounds.
Surgery, NEWCASTLE UNIVERSITY Co-Supervisor
2013 Honours A randomised clinical trial to assess the efficacy of bolus vs infusion as a mode of delivery for local anaesthetic blocks following abdominal surgery
This was a randomised clinical trial of two methods of delivery of local anaesthetic to manage post-operative pain in patients who underwent abdominal surgery. &nbsp;The trial showed a modest difference in favour of bolus delivery. &nbsp;The trial included 120 patients. It has been presented at the Royal Australasian College of Surgeons Annual Scientific Meeting in 2015
Surgery, NEWCASTLE UNIVERSITY Co-Supervisor
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News

Major funding to train the next generation of surgical researchers and reduce surgical infections

October 9, 2019

Academic surgeons from across Australia have been awarded more than $780,000 from the Medical Research Future Fund (MRFF) to investigate the causes of surgical site infections and train the next generation of surgical researchers.

Dr Peter Pockney

Position

Conjoint Senior Lecturer
School of Medicine and Public Health
College of Health, Medicine and Wellbeing

Focus area

Medicine

Contact Details

Email peter.pockney@newcastle.edu.au
Phone (02) 4985 5527
Fax (02) 4921 4274

Office

Building .
Location John Hunter Hospital, Newcastle

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