2020 |
Balogh ZJ, King KL, 'Perspectives on tranexamic acid in surgery', ANZ JOURNAL OF SURGERY, 90 409-409 (2020)
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2020 |
Devaney GL, Bulman J, King KL, Balogh ZJ, 'Time to definitive fixation of pelvic and acetabular fractures', Journal of Trauma and Acute Care Surgery, 89 730-735 (2020) [C1]
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2020 |
Amico F, Anning R, Bendinelli C, Balogh ZJ, Participants of the 2019 World Society of Emergency Surgery (WSES) Nijmegen splenic injury collaboration group, 'Grade III blunt splenic injury without contrast extravasation - World Society of Emergency Surgery Nijmegen consensus practice.', World J Emerg Surg, 15 46 (2020)
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2020 |
Tarrant SM, Catanach MJ, Sarrami M, Clapham M, Attia J, Balogh ZJ, 'Direct Oral Anticoagulants and Timing of Hip Fracture Surgery', JOURNAL OF CLINICAL MEDICINE, 9 (2020) [C1]
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2020 |
Devaney GL, King KL, Balogh ZJ, 'Pelvic angioembolization: how urgently needed?', Eur J Trauma Emerg Surg, (2020)
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2020 |
Flabouris A, Civil IDS, Balogh ZJ, Isles S, 'The New Zealand trauma system verification', Journal of Trauma and Acute Care Surgery, 89 585-596 (2020) [C1]
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2020 |
Walsh M, Thomas S, Kwaan H, Aversa J, Anderson S, Sundararajan R, et al., 'Modern methods for monitoring hemorrhagic resuscitation in the United States: Why the delay?', J Trauma Acute Care Surg, 89 1018-1022 (2020)
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2020 |
Tarrant SM, Kim RG, McGregor KL, Palazzi K, Attia J, Balogh ZJ, 'Dual Antiplatelet Therapy and Surgical Timing in Geriatric Hip Fracture', Journal of orthopaedic trauma, 34 559-565 (2020) [C1]
OBJECTIVE: To determine how timing of surgery affects transfusion, major complications, and mortality in patients who sustain a geriatric hip fracture while taking dual antiplatel... [more]
OBJECTIVE: To determine how timing of surgery affects transfusion, major complications, and mortality in patients who sustain a geriatric hip fracture while taking dual antiplatelet therapy (DAPT; typically aspirin and clopidogrel). DESIGN: Retrospective cohort study. SETTING: University-affiliated Level 1 Trauma Center. PATIENTS: Patients 65 years of age or older on DAPT with a geriatric hip fracture were investigated at a single institution between 2002 and 2017. Demographic and perioperative data were collected from patient records, institutional databases, and national hip fracture registry. INTERVENTION: Fixation or arthroplasty. MAIN OUTCOME MEASUREMENT: Transfusion, major complications, and 30-day mortality. RESULTS: Of the 6724 patients sustaining a geriatric hip fracture, 122 patients were taking DAPT on admission. Timing of surgery did not influence transfused units (incidence rate ratio 1.00, 95% confidence interval: 0.87-1.15, P = 0.968) but did affect major complications (time modeled as quadratic term; odds ratios ranging from 0.20 to 7.91, ptime = 0.001, ptime*time<0.001) and 30-day mortality (odds ratio 1.32, 95% confidence interval: 1.03-1.68, P = 0.030). CONCLUSION: Surgical delay does not change the need for transfusion of hip fracture patients on DAPT, but it is associated with increased probabilities of major complications and 30-day mortality. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
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2020 |
Balogh ZJ, Way TL, Hoswell RL, 'The epidemiology of trauma during a pandemic', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 51 1243-1244 (2020)
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2020 |
Tarrant SM, Balogh ZJ, 'The Global Burden of Surgical Management of Osteoporotic Fractures', World Journal of Surgery, 44 1009-1019 (2020) [C1]
© 2020, Société Internationale de Chirurgie. Osteoporosis is an epidemic in the developed world. Fracture is a major burden associated with osteoporosis. Surgical management is re... [more]
© 2020, Société Internationale de Chirurgie. Osteoporosis is an epidemic in the developed world. Fracture is a major burden associated with osteoporosis. Surgical management is recommended for particular anatomical areas, whilst other fracture patterns have a less defined and controversial role for surgery. This review aims to highlight increase in the global burden of osteoporosis and subsequent fragility fractures. As health and life expectancy improves, osteoporotic fracture fixation will constitute a significant physical and economic burden. The surgical management of osteoporotic fractures involves awareness on all levels from government to the individual, from primary prevention of fracture to surgical aftercare in the community.
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2020 |
Bierl C, Balogh ZJ, 'Not Shockingly the CO2 Gap Correlates With Mortality.', Crit Care Med, 48 1914-1915 (2020)
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2020 |
Caterson AD, Olthof DC, Abel C, Balogh ZJ, 'The morphology of ligamentous sacroiliac lesions - challenge to the antero-posterior compression mechanism.', Injury, (2020)
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2020 |
Balogh ZJ, 'The Surgical Burden of Musculoskeletal Conditions and Injuries', WORLD JOURNAL OF SURGERY, 44 1007-1008 (2020)
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2020 |
Coimbra R, Edwards S, Kurihara H, Bass GA, Balogh ZJ, Tilsed J, et al., 'European Society of Trauma and Emergency Surgery (ESTES) recommendations for trauma and emergency surgery preparation during times of COVID-19 infection', European Journal of Trauma and Emergency Surgery, 46 505-510 (2020) [C1]
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. A series of recommendations regarding hospital perioperative preparation for the COVID-19 pandemic were compiled to ... [more]
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. A series of recommendations regarding hospital perioperative preparation for the COVID-19 pandemic were compiled to inform surgeons worldwide on how to provide emergency surgery and trauma care during enduring times.The recommendations are divided into eight domains: (1) General recommendation for surgical services; (2) Emergency Surgery for critically ill COVID-19 positive or suspected patients -Preoperative planning and case selection; (3) Operating Room setup; (4) patient transport to the OR; (5) Surgical staff preparation; (6) Anesthesia considerations; (7) Surgical approach; and (8) Case Completion.The European Society of Emergency Surgery board endorsed these recommendations.
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2020 |
Bendinelli C, Ku D, King KL, Nebauer S, Balogh ZJ, 'Trauma patients with prehospital Glasgow Coma Scale less than nine: not a homogenous group', European Journal of Trauma and Emergency Surgery, 46 873-878 (2020) [C1]
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Prehospital guidelines stratify and manage patients with Glasgow Coma Scale (GCS) less than nine and any si... [more]
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Prehospital guidelines stratify and manage patients with Glasgow Coma Scale (GCS) less than nine and any sign of head injury as affected by severe traumatic brain injury (STBI). We hypothesized that this group of patients is so inhomogeneous that uniform treatment guidelines cannot be advocated. Methods: Patients (2005¿2012) with prehospital GCS below nine and abbreviated injury scale head and neck above two were identified from trauma registry. Patients with acute lethal injuries, isolated neck injuries, extubated within 24¿h or transferred interhospitally were excluded. Patients were dichotomized based on the worst prehospital GCS (recorded before sedatives) into two groups: GCS 3¿5 and GCS 6¿8. These were statistically compared using univariate analysis. Results: The GCS 3¿5 group (99 patients) when compared with the GCS 6¿8 group (49 patients) had shorter prehospital times (63 vs. 79¿min; p < 0.05), more frequent episodes of both hypoxia (30.3% vs. 7.7%; p < 0.05) and hypotension (26.7% vs. 6.4%; p < 0.05), more often required craniectomy (15.1% vs. 4.0%; p = 0.05) and higher mortality (33.3% vs. 2%; p < 0.05). In the GCS 3¿5 group, prehospital endotracheal intubation was attempted more often (57.5% vs. 28.6%, p < 0.05) and was more often successful (39.3% vs. 10.2%; p = 0.05). Length of stay in ICU did not differ. Conclusions: STBI patients are fundamentally different based on whether their initial GCS falls into 3¿5 or 6¿8 category. Recommendations from trials investigating trauma patients with GCS less than nine as one group should be translated with caution to clinical practice.
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2020 |
Lawson A, Naylor J, Buchbinder R, Ivers R, Balogh Z, Smith P, et al., 'A Combined Randomised and Observational Study of Surgery for Fractures In the distal Radius in the Elderly (CROSSFIRE): a statistical analyses plan', TRIALS, 21 (2020)
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2020 |
Benz D, Tarrant SM, Balogh ZJ, 'Proximal femur fracture non-union with or without implant failure: A revision technique with clinical outcomes', Injury, 51 1925-1930 (2020) [C1]
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2020 |
Di Saverio S, Podda M, De Simone B, Ceresoli M, Augustin G, Gori A, et al., 'Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines', WORLD JOURNAL OF EMERGENCY SURGERY, 15 (2020) [C1]
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2020 |
Wheeler JA, Weaver N, Balogh ZJ, Drobetz H, Kovendy A, Enninghorst N, 'Radiation Exposure in Patients with Isolated Limb Trauma: Acceptable or Are We Imaging Too Much?', J Clin Med, 9 (2020)
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2020 |
Way TL, Tarrant SM, Balogh ZJ, 'Social restrictions during COVID-19 and major trauma volume at a level 1 trauma centre.', Med J Aust, (2020)
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2020 |
Balogh ZJ, Way TL, Bendinelli C, Warren K-RJ, 'Current concepts on haemorrhage control in severe trauma', ANZ JOURNAL OF SURGERY, 90 406-408 (2020)
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2020 |
Briggs GD, Balogh ZJ, 'Tranexamic acid and inflammation in trauma', ANZ JOURNAL OF SURGERY, 90 426-428 (2020)
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2020 |
Cooper S, Bendinelli C, Bivard A, Parsons M, Balogh ZJ, 'Abnormalities on Perfusion CT and Intervention for Intracranial Hypertension in Severe Traumatic Brain Injury.', J Clin Med, 9 (2020)
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2019 |
Warren K-RJ, Balogh ZJ, 'Major vascular trauma', EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY, 45 941-942 (2019)
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2019 |
Cooper S, Bendinelli C, Bivard A, Parsons M, Balogh ZJ, 'When a Slice Is Not Enough! Comparison of Whole-Brain versus Standard Limited-Slice Perfusion Computed Tomography in Patients with Severe Traumatic Brain Injury', JOURNAL OF CLINICAL MEDICINE, 8 (2019) [C1]
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2019 |
Kyriakedes JC, Crijns TJ, Teunis T, Ring D, Bafus BT, Abdel-Ghany M, et al., 'International Survey: Factors Associated With Operative Treatment of Distal Radius Fractures and Implications for the American Academy of Orthopaedic Surgeons' Appropriate Use Criteria', JOURNAL OF ORTHOPAEDIC TRAUMA, 33 E394-E402 (2019)
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2019 |
Gomez D, Sarrami P, Singh H, Balogh ZJ, Dinh M, Hsu J, 'External benchmarking of trauma services in New South Wales: Risk-adjusted mortality after moderate to severe injury from 2012 to 2016', Injury, 50 178-185 (2019) [C1]
© 2018 Elsevier Ltd Background: Trauma centres and systems have been associated with improved morbidity and mortality after injury. However, variability in outcomes across centres... [more]
© 2018 Elsevier Ltd Background: Trauma centres and systems have been associated with improved morbidity and mortality after injury. However, variability in outcomes across centres within a given system have been demonstrated. Performance improvement initiatives, that utilize external benchmarking as the backbone, have demonstrated system-wide improvements in outcomes. This data driven approach has been lacking in Australia to date. Recent improvement in local data quality may provide the opportunity to engage in data driven performance improvement. Our objective was to generate risk-adjusted outcomes for the purpose of external benchmarking of trauma services in New South Wales (NSW) based on existing data standards. Methods: Retrospective cohort study of the NSW Trauma Registry. We included adults (>16 years), with an Injury Severity Score >12, that received definitive care at either Major Trauma Services (MTS) or Regional Trauma Services (RTS) between 2012-2016. Hierarchical logistic regression models were then used to generate risk-adjusted outcomes. Our outcome measure was in-hospital death. Demographics, vital signs, transfer status, survival risk ratios, and injury characteristics were included as fixed-effects. Median odds ratios (MOR) and centre-specific odds ratios with 95% confidence intervals were generated. Centre-level variables were explored as sources of variability in outcomes. Results: 14,452 patients received definitive care at one of seven MTS (n = 12,547) or ten RTS (n = 1905). Unadjusted mortality was lower at MTS (9.4%) compared to RTS (11.2%). After adjusting for case-mix, the MOR was 1.33, suggesting that the odds of death was 1.33-fold greater if a patient was admitted to a randomly selected centre with worse as opposed to better risk-adjusted mortality. Definitive care at an MTS was associated with a 41% lower likelihood of death compared to definitive care at an RTS (OR 0.59 95%CI 0.35-0.97). Similar findings were present in the elderly and isolated severe brain injury subgroups. Conclusions: The NSW trauma system exhibited variability in risk-adjusted outcomes that did not appear to be explained by case-mix. A better understanding of the drivers of the described variation in outcomes is crucial to design targeted locally-relevant quality improvement interventions.
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2019 |
Benz D, Lim P, Balogh ZJ, 'Acute atraumatic bilateral acetabular insufficiency fractures', JOURNAL OF ORTHOPAEDIC SURGERY, 27 (2019)
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2019 |
Amico F, Briggs G, Balogh ZJ, 'Transfused trauma patients have better outcomes when transfused with blood components from young donors', Medical Hypotheses, 122 141-146 (2019) [C1]
© 2018 The physiology of tissue healing and aging share common pathways. Both patient age and tissue healing are crucial factors predicting outcomes in trauma patients. The presen... [more]
© 2018 The physiology of tissue healing and aging share common pathways. Both patient age and tissue healing are crucial factors predicting outcomes in trauma patients. The presented hypothesis focuses on the concept that transfused trauma patients have better outcomes when transfused with blood components from young donors. The age of the donor of a blood transfusion could affect recovery following a major traumatic insult and help avoid postinjury immune paralysis and its associated complications. The frequent transfusion of blood components to the severely injured trauma patient provides an opportunity for the recipient to benefit from the potentially favourable effect of blood originating from young donors. Different types of evidence support the presented hypothesis including work on soluble circulating factors, research on animal parabiontic models and epidemiological studies. Theories on the role of transfusion of cells, on bone marrow and on senolytics also represent grounds to elaborate pathways to test this hypothesis. The precise molecular mechanism underlying this hypothesis is uncertain. A beneficial effect on trauma patients following transfusion of blood could be due to a positive effect of blood donated from younger donors or instead to the lack of a negative effect possibly occurring when transfusing blood from older donors. Either way, identifying this mechanism would provide a powerful tool enhance long and short term recovery after trauma.
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2019 |
Doig CJ, Page SA, McKee JL, Moore EE, Abu-Zidan FM, Carroll R, et al., 'Ethical considerations in conducting surgical research in severe complicated intra-abdominal sepsis', World Journal of Emergency Surgery, 14 (2019)
© 2019 The Author(s). Background: Severe complicated intra-abdominal sepsis (SCIAS) has high mortality, thought due in part to progressive bio-mediator generation, systemic inflam... [more]
© 2019 The Author(s). Background: Severe complicated intra-abdominal sepsis (SCIAS) has high mortality, thought due in part to progressive bio-mediator generation, systemic inflammation, and multiple organ failure. Treatment includes early antibiotics and operative source control. At surgery, open abdomen management with negative-peritoneal-pressure therapy (NPPT) has been hypothesized to mitigate MOF and death, although clinical equipoise for this operative approach exists. The Closed or Open after Laparotomy (COOL) study (https://clinicaltrials.gov/ct2/show/NCT03163095) will prospectively randomize eligible patients intra-operatively to formal abdominal closure or OA with NPTT. We review the ethical basis for conducting research in SCIAS. Main body: Research in critically ill incapacitated patients is important to advance care. Conducting research among SCIAS is complicated due to the severity of illness including delirium, need for emergent interventions, diagnostic criteria confirmed only at laparotomy, and obtundation from anaesthesia. In other circumstances involving critically ill patients, clinical experts have worked closely with ethicists to apply principles that balance the rights of patients whilst simultaneously permitting inclusion in research. In Canada, the Tri-Council Policy Statement-2 (TCPS-2) describes six criteria that permit study enrollment and randomization in such situations: (a) serious threat to the prospective participant requires immediate intervention; (b) either no standard efficacious care exists or the research offers realistic possibility of direct benefit; (c) risks are not greater than that involved in standard care or are clearly justified by prospect for direct benefits; (d) prospective participant is unconscious or lacks capacity to understand the complexities of the research; (e) third-party authorization cannot be secured in sufficient time; and (f) no relevant prior directives are known to exist that preclude participation. TCPS-2 criteria are in principle not dissimilar to other (inter)national criteria. The COOL study will use waiver of consent to initiate enrollment and randomization, followed by surrogate or proxy consent, and finally delayed informed consent in subjects that survive and regain capacity. Conclusions: A delayed consent mechanism is a practical and ethical solution to challenges in research in SCIAS. The ultimate goal of consent is to balance respect for patient participants and to permit participation in new trials with a reasonable opportunity for improved outcome and minimal risk of harm.
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2019 |
Picetti E, Rossi S, Abu-Zidan FM, Ansaloni L, Armonda R, Baiocchi GL, et al., 'WSES consensus conference guidelines: Monitoring and management of severe adult traumatic brain injury patients with polytrauma in the first 24 hours', World Journal of Emergency Surgery, 14 1-9 (2019) [C1]
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2019 |
King KL, Balogh ZJ, 'Trauma registry: focus, funding and the future', ANZ JOURNAL OF SURGERY, 89 276-276 (2019)
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2019 |
Balogh ZJ, 'Damage control The goal posts have not only shifted but we are playing on another field', Injury, 50 1007-1008 (2019)
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2019 |
McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Palazzi K, et al., 'Comorbid tobacco and other substance use and symptoms of anxiety and depression among hospitalised orthopaedic trauma patients', BMC PSYCHIATRY, 19 (2019) [C1]
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2019 |
Civil I, Balogh Z, 'Nothing lasts forever: Donald D. Trunkey, MD, FACS 1937-2019', ANZ JOURNAL OF SURGERY, 89 807-808 (2019)
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2018 |
Ghoshal A, Enninghorst N, Sisak K, Balogh ZJ, 'An interobserver reliability comparison between the Orthopaedic Trauma Association's open fracture classification and the Gustilo and Anderson classification', Bone and Joint Journal, 100B 242-246 (2018) [C1]
© 2018 The British Editorial Society of Bone and Joint Surgery. Aims To evaluate interobserver reliability of the Orthopaedic Trauma Association's open fracture classificatio... [more]
© 2018 The British Editorial Society of Bone and Joint Surgery. Aims To evaluate interobserver reliability of the Orthopaedic Trauma Association's open fracture classification system (OTA-OFC). Patients and Methods Patients of any age with a first presentation of an open long bone fracture were included. Standard radiographs, wound photographs, and a short clinical description were given to eight orthopaedic surgeons, who independently evaluated the injury using both the Gustilo and Anderson (GA) and OTA-OFC classifications. The responses were compared for variability using Cohen's kappa. Results The overall interobserver agreement was ¿ = 0.44 for the GA classification and ¿ = 0.49 for OTA-OFC, which reflects moderate agreement (0.41 to 0.60) for both classifications. The agreement in the five categories of OTA-OFC was: for skin, ¿ = 0.55 (moderate); for muscle, ¿ = 0.44 (moderate); for arterial injury, ¿ = 0.74 (substantial); for contamination, ¿ = 0.35 (fair); and for bone loss, ¿ = 0.41 (moderate). Conclusion Although the OTA-OFC, with similar interobserver agreement to GA, offers a more detailed description of open fractures, further development may be needed to make it a reliable and robust tool.
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2018 |
Coccolini F, Roberts D, Ansaloni L, Ivatury R, Gamberini E, Kluger Y, et al., 'The open abdomen in trauma and non-trauma patients: WSES guidelines', World Journal of Emergency Surgery, 13 (2018) [C1]
© 2018 The Author(s). Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicio... [more]
© 2018 The Author(s). Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a "planned second-look" laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption. The open abdomen in trauma and non-trauma patients has been proposed to be effective in preventing or treating deranged physiology in patients with severe injuries or critical illness when no other perceived options exist. Its use, however, remains controversial as it is resource consuming and represents a non-anatomic situation with the potential for severe adverse effects. Its use, therefore, should only be considered in patients who would most benefit from it. Abdominal fascia-to-fascia closure should be done as soon as the patient can physiologically tolerate it. All precautions to minimize complications should be implemented.
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2018 |
Hirani R, Dean MM, Balogh ZJ, Lott NJ, Seggie J, Hsu JM, et al., 'Donor white blood cell survival and cytokine profiles following red blood cell transfusion in Australian major trauma patients', MOLECULAR IMMUNOLOGY, 103 229-234 (2018)
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2018 |
Bendinelli C, Ku D, Nebauer S, King KL, Howard T, Gruen R, et al., 'A tale of two cities: prehospital intubation with or without paralysing agents for traumatic brain injury.', ANZ journal of surgery, 88 455-459 (2018) [C1]
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2018 |
Ten Broek RPG, Krielen P, Di Saverio S, Coccolini F, Biffl WL, Ansaloni L, et al., 'Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group', WORLD JOURNAL OF EMERGENCY SURGERY, 13 (2018) [C1]
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2018 |
Kirkpatrick AW, Coccolini F, Ansaloni L, Roberts DJ, Tolonen M, McKee JL, et al., 'Closed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial', WORLD JOURNAL OF EMERGENCY SURGERY, 13 (2018)
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2018 |
Balogh ZJ, Marzi I, 'Novel concepts related to inflammatory complications in polytrauma', EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY, 44 299-300 (2018)
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2018 |
Brady J, Hardy BM, Yoshino O, Buxton A, Quail A, Balogh ZJ, 'The effect of haemorrhagic shock and resuscitation on fracture healing in a rabbit model: An animal study', Bone and Joint Journal, 100B 1234-1240 (2018) [C1]
© 2018 Author(s) et al. Aims: Little is known about the effect of haemorrhagic shock and resuscitation on fracture healing. This study used a rabbit model with a femoral osteotomy... [more]
© 2018 Author(s) et al. Aims: Little is known about the effect of haemorrhagic shock and resuscitation on fracture healing. This study used a rabbit model with a femoral osteotomy and fixation to examine this relationship. Materials and Methods: A total of 18 male New Zealand white rabbits underwent femoral osteotomy with intramedullary fixation with 'shock' (n = 9) and control (n = 9) groups. Shock was induced in the study group by removal of 35% of the total blood volume 45 minutes before resuscitation with blood and crystalloid. Fracture healing was monitored for eight weeks using serum markers of healing and radiographs. Results: Four animals were excluded due to postoperative complications. The serum concentration of osteocalcin was significantly elevated in the shock group postoperatively (p < 0.0001). There were otherwise no differences with regard to serum markers of bone healing. The callus index was consistently increased in the shock group on anteroposterior (p = 0.0069) and lateral (p = 0.0165) radiographs from three weeks postoperatively. The control group showed an earlier decrease of callus index. Radiographic scores were significantly greater in the control group (p = 0.0025). Conclusion: In a rabbit femoral osteotomy model with intramedullary fixation, haemorrhagic shock and resuscitation produced larger callus but with evidence of delayed remodelling.
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2018 |
Thurairajah K, Briggs GD, Balogh ZJ, 'The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies', European Journal of Trauma and Emergency Surgery, 44 325-334 (2018) [C1]
© 2018, The Author(s). Mitochondria play a key role in the pathophysiology of post-injury inflammation. Cell-free mitochondrial DNA (cf-mtDNA) is now understood to catalyse steril... [more]
© 2018, The Author(s). Mitochondria play a key role in the pathophysiology of post-injury inflammation. Cell-free mitochondrial DNA (cf-mtDNA) is now understood to catalyse sterile inflammation after trauma. Observations in trauma cohorts have identified high cf-mtDNA in patients with systemic inflammatory response syndrome and multiple organ failure as well as following major surgery. The source of cf-mtDNA can be various cells affected by mechanical and hypoxic injury (passive mechanism) or induced by inflammatory mechanisms (active mechanism). Multiple forms of cf-mtDNA exist; mtDNA fragments, mtDNA in microparticles/vesicles and cell-free mitochondria. Trauma to cells that are rich in mitochondria are believed to release more cf-mtDNA. This review describes the current understanding of the mechanisms of cf-mtDNA release, its systemic effects and the potential therapeutic implications related to its modification. Although current understanding is insufficient to change trauma management, focussed research goals have been identified to pave the way for monitoring and manipulation of cf-mtDNA release and effects in trauma.
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2018 |
Warren K-RJ, Balogh ZJ, 'Viscoelastic tests in trauma care', ANZ JOURNAL OF SURGERY, 88 664-665 (2018)
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2018 |
McIlroy DJ, Minahan K, Keely S, Lott N, Hansbro P, Smith DW, Balogh ZJ, 'Reduced deoxyribonuclease enzyme activity in response to high postinjury mitochondrial DNA concentration provides a therapeutic target for Systemic Inflammatory Response Syndrome.', J Trauma Acute Care Surg, 85 354-358 (2018) [C1]
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2018 |
McIlroy DJ, Minahan K, Keely S, Lott N, Hansbro P, Smith DW, Balogh ZJ, 'Reduced deoxyribonuclease enzyme activity in response to high postinjury mitochondrial DNA concentration provides a therapeutic target for Systemic Inflammatory Response Syndrome.', J Trauma Acute Care Surg, 85 354-358 (2018)
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2017 |
Bala M, Kashuk J, Moore EE, Kluger Y, Biffl W, Gomes CA, et al., 'Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery.', World J Emerg Surg, 12 38 (2017) [C1]
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2017 |
Coccolini F, Stahel PF, Montori G, Biffl W, Horer TM, Catena F, et al., 'Pelvic trauma: WSES classification and guidelines', World Journal of Emergency Surgery, 12 (2017) [C1]
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2017 |
Asehnoune K, Balogh Z, Citerio G, Cap A, Billiar T, Stocchetti N, et al., 'The research agenda for trauma critical care', Intensive Care Medicine, 43 1340-1351 (2017) [C1]
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2017 |
Thurairajah K, Broadhead ML, Balogh ZJ, 'Trauma and stem cells: Biology and potential therapeutic implications', International Journal of Molecular Sciences, 18 1-18 (2017) [C1]
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2017 |
Sartelli M, Kluger Y, Ansaloni L, Carlet J, Brink A, Hardcastle TC, et al., 'A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway', SURGICAL INFECTIONS, 18 846-853 (2017)
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2017 |
Stott S, Balogh ZJ, 'Postoperative Computed Tomography for Articular Fractures: A Systematic Review', Journal of Orthopaedic Trauma, 31 56-61 (2017) [C1]
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2017 |
Hauser CJ, Barrett C, Robinson BRH, Balogh ZJ, Dries DJ, Simmons JD, 'Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 82 1028-1029 (2017) |
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2017 |
Galante JM, Cryer HG, Moore EE, Demoya MA, Balogh ZJ, Costantini TW, 'Pelvic fracture pattern predicts the need for hemorrhage control intervention-Results of an AAST multi-institutional study DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 82 1036-1038 (2017) |
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2017 |
Oliver M, Dinh MM, Curtis K, Paschkewitz R, Rigby O, Balogh ZJ, 'Trends in Procedures at Major Trauma Centres in New South Wales, Australia: An Analysis of State-Wide Trauma Data', World Journal of Surgery, 41 2000-2005 (2017) [C1]
© 2017, Société Internationale de Chirurgie. Objectives: To describe the trend in major trauma surgical procedures and interventional radiology in major trauma patients in Austral... [more]
© 2017, Société Internationale de Chirurgie. Objectives: To describe the trend in major trauma surgical procedures and interventional radiology in major trauma patients in Australia over the past 6 years. Methods: This was a retrospective review of adult major trauma (Injury Severity Score greater than 15) patients using the New South Wales Statewide Trauma Registry between 2009 and 2014. Major trauma surgical procedures were classified into abdominal, neurosurgery, cardiothoracic and interventional radiology. The proportion of patients undergoing such procedures per year was the outcome of interest. Results: There were around ten thousand cases analysed. The proportion of cases undergoing interventional radiology procedures increased from 1% in 2009 to around 6% in 2014. Other major trauma surgical procedures remained stable. Only around 100 laparotomies were performed in 2014. The predictors of having an IR procedure performed were increasing from 2009 (OR 1.5 95% CI 1.4, 1.6 p¿<¿0.001), hypotension (OR 1.5 95% CI 1.1, 2.1 n¿=¿0.01), severe abdominal injury (OR 4.2 95% CI 3.2, 5.3 p¿<¿0.001) and lower limb (including pelvic) injury (OR 3.8 95% CI 3.0, 4.7 p¿<¿0.001). Conclusion: There has been a rapid increase in the use of interventional radiology over the past few years which will need to be addressed in future trauma service planning and models of care.
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2017 |
Croker N, Lobo A, Croker A, Balogh ZJ, Dewar D, 'Who, where, what and where to now? A snapshot of publishing patterns in Australian orthopaedic surgery', ANZ Journal of Surgery, 87 1044-1047 (2017) [C1]
© 2017 The Authors ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons Background: Development of core r... [more]
© 2017 The Authors ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons Background: Development of core research competency is a principle of orthopaedic surgical training in Australia. This paper aims to provide an objective snapshot of publications by Australian orthopaedic trainees and surgeons, to contribute to the discussion on how to identify and build on research capability in the Australian Orthopaedic Association (AOA). Methods: By analysing journals with a journal impact factor >1 from 2009 to 2015, data were gathered to explore scientific journal publications by Australian orthopaedic surgeons and trainees in relation to who are the authors, what they are reporting and where they are publishing. Results: One thousand five hundred and thirty-nine articles were identified with 134 orthopaedic trainees and 519 surgeons as authors. The publication rate for both trainees and surgeons was just over two in five. The majority of studies were of level three or four evidence (Oxford's Centre for Evidence-Based Medicine guidelines). Only 5% of trainee papers were published without surgeons¿ co-authorship. Eighty-six percent of papers published by surgeons did not involve a trainee. The rates of trainees publishing with other trainees were low. Conclusion: Only 5% of trainee papers were published without surgeons' co-authorship, highlighting the importance of surgeon mentorship in developing trainee research capability. The 86% of papers published by surgeons without trainee co-authorship raises the question of missed mentoring opportunities. Low rates of trainee co-authorship highlight potential for trainees to work together to support each other's research efforts. There is scope for more studies involving higher levels of evidence. This paper raises discussion points and areas for further exploration in relation to AOA trainee research capability.
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2017 |
Sartelli M, Chichom-Mefire A, Labricciosa FM, Hardcastle T, Abu-Zidan FM, Adesunkanmi AK, et al., 'The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of ntra-abdominal infections (vol 12, 29, 2017)', WORLD JOURNAL OF EMERGENCY SURGERY, 12 (2017)
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2017 |
Benz D, Balogh ZJ, 'Damage control surgery: current state and future directions.', Current opinion in critical care, 23 491-497 (2017) [C1]
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2017 |
Tuboly E, McIlroy D, Briggs G, Lott N, Balogh ZJ, 'Clinical implications and pathological associations of circulating mitochondrial DNA', Frontiers in Bioscience - Landmark, 22 1011-1022 (2017) [C1]
Mitochondria are membrane-enclosed organelles, the energy-producing centers in almost all eukaryotic cells. The evolutionary emergence of mitochondria is a result of the endocytos... [more]
Mitochondria are membrane-enclosed organelles, the energy-producing centers in almost all eukaryotic cells. The evolutionary emergence of mitochondria is a result of the endocytosis of a-proteobacteria. There are several characteristic features which refer to its prokaryotic ancestors including its independent sets of double-stranded mitochondrial DNA, which is uniquely circular in form and contains a significant amount of unmethylated DNA as CpG islands. Resent research has proven that free mitochondrial DNA found in blood was associated with innate immunomodulation in a broad-range of clinical conditions. Upon release, mitochondrial DNA acts as a danger-associated molecular pattern in the circulation, it is recognized by pattern recognition receptors and it facilitates inflammatory responses. Besides its high receptor activation potential, mitochondrial DNA is likely to perform direct crosstalk with activated leukocytes and to be contributed to other anti-microbial activities. Here we highlight the pathological conditions where cell free mtDNA is involved, describe the potential sources and mechanisms of extracellular mtDNA release and explore evidence for its mechanism of action after being excreted and potential therapeutic strategies.
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2017 |
McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Naylor J, et al., 'Smoke-free recovery from trauma surgery: A pilot trial of an online smoking cessation program for orthopaedic trauma patients', International Journal of Environmental Research and Public Health, 14 1-12 (2017) [C1]
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2017 |
Harris IA, Naylor JM, Lawson A, Buchbinder R, Ivers R, Balogh Z, et al., 'A combined randomised and observational study of surgery for fractures in the distal radius in the elderly (CROSSFIRE) - a study protocol', BMJ OPEN, 7 (2017)
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2017 |
McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Palazzi K, et al., 'Who is More Likely to Use the Internet for Health Behavior Change? A Cross-Sectional Survey of Internet Use Among Smokers and Nonsmokers Who Are Orthopedic Trauma Patients.', JMIR Ment Health, 4 e18 (2017) [C1]
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2017 |
McCrabb S, Balogh Z, Baker AL, Harris IA, Attia J, Lott N, et al., 'Development of an online smoking cessation program for use in hospital and following discharge: Smoke-free recovery', BMJ Innovations, 3 115-122 (2017) [C1]
© 2017, BMJ Publishing Group. All rights reserved. Background Tobacco smoking can have negative health outcomes on recovery from surgery. Although it is recommended best practice ... [more]
© 2017, BMJ Publishing Group. All rights reserved. Background Tobacco smoking can have negative health outcomes on recovery from surgery. Although it is recommended best practice to provide patients with advice to quit and follow-up support, provision of postdischarge support is rare. Developing an online smoking cessation program may help address this gap. Objectives This paper describes the development and pretesting of an online smoking cessation program (smoke-free recovery, SFR) tailored to the orthopaedic trauma population for use while in hospital and post-discharge. Methods Drawing on the DoTTI framework for developing an online program, the following steps were followed for program development: (1) design and development; (2) testing early iteration; (3) testing for effectiveness and (4) integration and implementation. This article describes the first two stages of SFR program development. Results SFR is a 10-module online smoking cessation program tailored for patients with orthopaedic trauma. Of the participants who completed testing early iterations, none reported any difficulties orientating themselves to the program or understanding program content. The main themes were that it was ¿helpful¿, provision of ¿help to quit¿ was low and SFR increased thoughts of ¿staying quit post discharge¿. Conclusions This study found that a theory and evidence-based approach as the basis for an online smoking cessation program for patients with orthopaedic trauma was acceptable to users. A randomised controlled trial will be conducted to examine whether the online smoking cessation program is effective in increasing smoking cessation and how it can be integrated and implemented into hospital practice (stages three and four of the DoTTI framework).
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2017 |
Sartelli M, Chichom-Mefire A, Labricciosa FM, Hardcastle T, Abu-Zidan FM, Adesunkanmi AK, et al., 'The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections', World Journal of Emergency Surgery, 12 (2017) [C1]
© 2017 The Author(s). Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departme... [more]
© 2017 The Author(s). Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in the emergency departments worldwide. The cornerstones of effective treatment of IAIs are early recognition, adequate source control, and appropriate antimicrobial therapy. Prompt resuscitation of patients with ongoing sepsis is of utmost important. In hospitals worldwide, non-acceptance of, or lack of access to, accessible evidence-based practices and guidelines result in overall poorer outcome of patients suffering IAIs. The aim of this paper is to promote global standards of care in IAIs and update the 2013 WSES guidelines for management of intra-abdominal infections.
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2017 |
McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Palazzi K, et al., 'Smoking, Quitting, and the Provision of Smoking Cessation Support: A Survey of Orthopaedic Trauma Patients', Journal of Orthopaedic Trauma, 31 e255-e262 (2017) [C1]
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Objective: This study investigates orthopaedic trauma patients smoking cessation history, intentions to quit, rec... [more]
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Objective: This study investigates orthopaedic trauma patients smoking cessation history, intentions to quit, receipt of smoking cessation care during hospital admission, and patient-related factors associated with receipt of smoking cessation care. Methods: An online cross-sectional survey of orthopaedic trauma patients was conducted in 2 public hospitals in New South Wales, Australia. Prevalence of smoking and associated variables were described. Logistic regressions were used to examine whether patient characteristics were associated with receipt of smoking cessation care. Results: Eight hundred nineteen patients (response rate 73%) participated. More than 1 in 5 patients (21.8%) were current smokers (n = 175). Of the current smokers, more than half (55.3%) indicated making a quit attempt in the last 12 months and the majority (77.6%) were interested in quitting. More than a third of smokers (37.4%) were not advised to quit; 44.3% did not receive any form of nicotine replacement therapy; and 24.1% reported that they did not receive any of these 3 forms of smoking cessation care during their admission. Provision of care was not related to patient characteristics. Conclusions: The prevalence of smoking among the sample was high. Respondents were interested in quitting; however, the provision of care during admission was low. Smoking cessation interventions need to be developed to increase the provision of care and to promote quit attempts in this Australian population.
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2017 |
Sartelli M, Weber DG, Ruppe E, Bassetti M, Wright BJ, Ansaloni L, et al., 'Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) (vol 11, 33, 2016)', WORLD JOURNAL OF EMERGENCY SURGERY, 12 (2017)
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2017 |
McCrabb S, Baker AL, Attia J, Balogh ZJ, Lott N, Palazzi K, et al., 'Hospital smoke-free policy: Compliance, enforcement, and practices. A staff survey in two large public hospitals in Australia', International Journal of Environmental Research and Public Health, 14 (2017) [C1]
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2017 |
Yoshino O, Brady J, Young K, Hardy B, Matthys R, Buxton T, et al., 'Reamed locked intramedullary nailing for studying femur fracture and its complications', European Cells and Materials, 34 99-107 (2017) [C1]
© 2017, AO Research Institute. All rights reserved. Morbidity associated with femur fractures in polytrauma patients is known to be high. The many unsolved clinical questions incl... [more]
© 2017, AO Research Institute. All rights reserved. Morbidity associated with femur fractures in polytrauma patients is known to be high. The many unsolved clinical questions include the immunological effect of the fracture and its fixation, timing of fracture fixation, management of fracture non-union, effect of infection and critical size of bone defects. The aim of this study was to establish a clinically-relevant and reproducible animal model with regards to histological, biomechanical and radiological changes during bone healing. A custom-designed intramedullary nail with interlocking system (RabbitNail, RISystem AG, Davos Platz, Switzerland) was used for fixation, following femur fracture. New Zealand White rabbits were assigned to two groups: 1. closed fracture model (CF; non-survival model: n = 6, survival model: n = 3) with unilateral mid-shaft femur fracture created by blunt force; 2. osteotomy model (OT; survival model: n = 14) with unilateral transverse osteotomy creating femur fracture. There were no intraoperative complications and full-weight bearing was achieved in all survival rabbits. Significant periosteal reaction and callus formation were confirmed from 2 weeks postoperatively, with a significant volume formation (739.59 ± 62.14 mm3) at 8 weeks confirmed by micro-computed tomography (µ-CT). 2 months after fixation, there was no difference between the osteotomised and contralateral control femora in respect to the maximum torque (3.47 ± 0.35 N m vs. 3.26 ± 0.37 N m) and total energy (21.11 ± 3.09 N m × degree vs. 20.89 ± 2.63 N m × degree) required to break the femur. The data confirmed that a standardised internal fixation technique with an intramedullary nail for closed fracture or osteotomy produced satisfactory bone healing. It was concluded that important clinically-relevant studies can be conducted using this rabbit model.
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2017 |
Bendinelli C, Cooper S, Evans T, Bivard A, Pacey D, Parson M, Balogh ZJ, 'Perfusion Abnormalities are Frequently Detected by Early CT Perfusion and Predict Unfavourable Outcome Following Severe Traumatic Brain Injury', World Journal of Surgery, 41 2512-2520 (2017) [C1]
© 2017, Société Internationale de Chirurgie. Background: In patients with severe traumatic brain injury (TBI), early CT perfusion (CTP) provides additional information beyond the ... [more]
© 2017, Société Internationale de Chirurgie. Background: In patients with severe traumatic brain injury (TBI), early CT perfusion (CTP) provides additional information beyond the non-contrast CT (NCCT) and may alter clinical management. We hypothesized that this information may prognosticate functional outcome. Methods: Five-year prospective observational study was performed in a level-1 trauma centre on consecutive severe TBI patients. CTP (obtained in conjunction with first routine NCCT) was interpreted as: abnormal, area of altered perfusion more extensive than on NCCT, and the presence of ischaemia. Six months Glasgow Outcome Scale-Extended of four or less was considered an unfavourable outcome. Logistic regression analysis of CTP findings and core variables [preintubation Glasgow Coma Scale (GCS), Rotterdam score, base deficit, age] was conducted using Bayesian model averaging to identify the best predicting model for unfavourable outcome. Results: Fifty patients were investigated with CTP (one excluded for the absence of TBI) [male: 80%, median age: 35 (23¿55), prehospital intubation: 7 (14.2%); median GCS: 5 (3¿7); median injury severity score: 29 (20¿36); median head and neck abbreviated injury scale: 4 (4¿5); median days in ICU: 10 (5¿15)]. Thirty (50.8%) patients had an unfavourable outcome. GCS was a moderate predictor of unfavourable outcome (AUC¿=¿0.74), while CTP variables showed greater predictive ability (AUC for abnormal CTP¿=¿0.92; AUC for area of altered perfusion more extensive than NCCT¿=¿0.83; AUC for the presence of ischaemia¿=¿0.81). Conclusion: Following severe TBI, CTP performed at the time of the first follow-up NCCT, is a non-invasive and extremely valuable tool for early outcome prediction. The potential impact on management and its cost effectiveness deserves to be evaluated in large-scale studies. Level of evidence III: Prospective study.
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2016 |
Garner AA, Lee A, Weatherall A, Langcake M, Balogh ZJ, 'Physician staffed helicopter emergency medical service case identification - a before and after study in children', Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 24 (2016) [C1]
© 2016 The Author(s). Background: Severely injured children may have better outcomes when transported directly to a Paediatric Trauma Centre (PTC). A case identification system us... [more]
© 2016 The Author(s). Background: Severely injured children may have better outcomes when transported directly to a Paediatric Trauma Centre (PTC). A case identification system using the crew of a physician staffed helicopter emergency medical service (P-HEMS) that identified severely injured children for P-HEMS dispatch was previously associated with high rates of direct transfer. It was theorised that discontinuation of this system may have resulted in deterioration of system performance. Methods: Severe paediatric trauma cases were identified from a state based trauma registry over two time periods. In Period A the P-HEMS case identification system operated in parallel with a paramedic dispatcher (Rapid Launch Trauma Co-ordinator-RLTC) operating from a central control room (n = 71). In Period B the paramedic dispatcher operated in isolation (n = 126). Case identification and direct transfer rates were compared as was time to arrival at the PTC. Results: After cessation of the P-HEMS system the rate of case identification fell from 62 to 31 % (P < 0.001), identification of fatal cases fell from 100 to 47 % (P < 0.001), the rate of direct transfer to a PTC fell from 66 to 53 % (P = 0.076) and the time to arrival in a PTC increased from a median 69 (interquartile range 52 - 104) mins to 97 (interquartile range 56 - 305) mins (P = 0.003). When analysing the rate of direct transfer to a PTC as a function of team composition, after adjusting for age and injury severity scores, there was no change in the rate between the physician and paramedic groups across the two time periods (relative risk 0.92, 95 % CI: 0.44 to 1.41). Discussion: The parallel identification system improves case identification rates and decreases time to arrival at the PTC, whilst requiring RLTC authorisation preserves the safety and efficiency benefits of centralised dispatch. The model could be extended to adult patients with similar benefits. Conclusions: A case identification system relying solely on RLTC paramedics resulted in a significantly lower case identification rate and increased prehospital time with a non-significant fall in direct transfer rate to the PTC. The elimination of the P-HEMS input from the tasking system resulted in worse performance indicators and has the potential for poorer outcomes.
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2016 |
Kirkpatrick AW, Roberts DJ, De Waele J, Blaser AR, Malbrain MLNG, Bjorck M, Balogh ZJ, 'Permissive Intraabdominal Hypertension following Complex Abdominal Wall Reconstruction', PLASTIC AND RECONSTRUCTIVE SURGERY, 137 762E-764E (2016)
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2016 |
Di Saverio S, Birindelli A, Kelly MD, Catena F, Weber DG, Sartelli M, et al., 'WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis.', World J Emerg Surg, 11 34 (2016) [C1]
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2016 |
Miu J, Curtis K, Balogh ZJ, 'Profile of fall injury in the New South Wales older adult population', Australasian Emergency Nursing Journal, 19 179-185 (2016) [C1]
© 2016 Background A previous report from the New South Wales (NSW) Trauma Registry identified falls and increasing age of severely injured patients as highly prevalent, but detail... [more]
© 2016 Background A previous report from the New South Wales (NSW) Trauma Registry identified falls and increasing age of severely injured patients as highly prevalent, but detailed injury and demographic profiles, outcomes and their predictors are poorly reported. This study describes the fall-injury profile in the older adult major trauma patient in NSW. Methods A retrospective registry based study between 2010 and 2014 on patients aged 55 years and over who sustained a moderate to critical injury from a fall, examining mortality and length of stay using regression analyses. Results There were 4263 major trauma falls between 2010 and 2014, most occurring at home (55.4%), on the same level (46.7%) and resulting in head injury (63.2%). Significant predictors for mortality following a fall were increased age, male gender, falls in residential care institutions, isolated head injuries and injury classified as critical (ISS 41¿75). Conclusions The outcomes of falls in the older adult are very poor and a focused prospective study is required to identify areas for intervention and prevention. The predictors of mortality following a fall identified in this study can be used with existing research to develop tools and design care pathways for implementation in the emergency context to improve patient care and outcomes.
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2016 |
Dinh MM, Curtis K, Mitchell RJ, Bein KJ, Balogh ZJ, Seppelt I, et al., 'Major trauma mortality in rural and metropolitan NSW, 2009-2014: A retrospective analysis of trauma registry data', Medical Journal of Australia, 205 403-407 (2016) [C1]
© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. Objective: To determine trends in crude and risk-adjusted mortality for major trauma patients injured in rur... [more]
© 2016 AMPCo Pty Ltd. Produced with Elsevier B.V. All rights reserved. Objective: To determine trends in crude and risk-adjusted mortality for major trauma patients injured in rural or metropolitan New South Wales, 2009e2014. Design: A retrospective analysis of NSW statewide trauma registry data. Participants: Adult patients (aged 16 years or more) who presented with major trauma (Injury Severity Scores greater than 15) to a NSW hospital during 2009e2014. Main outcome measures: The main covariate of interest was geographic location of injury (metropolitan v rural/regional areas). Inpatientmortalitywasanalysedbymultivariable logistic regression. Results: Data for 11 423 eligible patients were analysed. Inpatient mortality for those injured in metropolitan locations was 14.7% in 2009 and 16.1% in 2014 (P = 0.45). In rural locations, there was a statistically significant decline in in-hospital mortality over the study period, from 12.1% in 2009 to 8.7% in 2014 (P = 0.004). Risk-adjusted mortality for those injured in a rural location was lower in 2013 than during 2009, but remained stable for those injured in metropolitan locations. Conclusion: Crude and risk-adjusted mortality after major trauma have remained stable in those injured in metropolitan areas of NSW between 2009 and 2014. The apparent downward trend in mortality associated with severe trauma in rural/regional locations requires further analysis.
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2016 |
Ansaloni L, Pisano M, Coccolini F, Peitzmann AB, Fingerhut A, Catena F, et al., '2016 WSES guidelines on acute calculous cholecystitis (vol 11, 25, 2016)', WORLD JOURNAL OF EMERGENCY SURGERY, 11 (2016)
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2016 |
Miu J, Dinh MM, Curtis K, Balogh ZJ, 'Ladder-related injuries in New South Wales', MEDICAL JOURNAL OF AUSTRALIA, 204 302-+ (2016)
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2016 |
Lumsdaine W, Weber DG, Balogh ZJ, 'Pelvic fracture-specific scales versus general patient reported scales for pelvic fracture outcomes: a systematic review', ANZ Journal of Surgery, 86 687-690 (2016) [C1]
© 2016 Royal Australasian College of Surgeons Background: Multiple scoring systems are used in the assessment of post-injury outcomes in pelvic fracture patients. Although commonl... [more]
© 2016 Royal Australasian College of Surgeons Background: Multiple scoring systems are used in the assessment of post-injury outcomes in pelvic fracture patients. Although commonly used, there is scarce evidence as to their validity. Methods: We performed a systematic review of the current literature to compare a well validated generic outcome tool (Short Form-36 (SF-36)) and three commonly used pelvic-specific outcome tools, the Iowa Pelvic Score, Majeed Pelvic Score and Orlando Pelvic Score. Results: Eleven papers were found that used both the SF-36 and one or more of the pelvic-specific outcome tools. The data demonstrate great variability in both the method of application and form of reporting. Conclusion: The pelvic-specific tools produce similar results to the SF-36 and are potentially more sensitive in examining specific areas related to pelvic injuries and easier to perform and calculate than the SF-36.
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2016 |
Ansaloni L, Pisano M, Coccolini F, Peitzmann AB, Fingerhut A, Catena F, et al., '2016 WSES guidelines on acute calculous cholecystitis', WORLD JOURNAL OF EMERGENCY SURGERY, 11 (2016) [C1]
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2016 |
Sartelli M, Weber DG, Ruppe E, Bassetti M, Wright BJ, Ansaloni L, et al., 'Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)', WORLD JOURNAL OF EMERGENCY SURGERY, 11 (2016) [C1]
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2016 |
Miu J, Dinh MM, Curtis K, Balogh ZJ, 'Ladder-related injuries in New South Wales', MEDICAL JOURNAL OF AUSTRALIA, 204 302-302 (2016)
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2015 |
Tarrant SM, Balogh ZJ, 'Low-energy falls', ANZ JOURNAL OF SURGERY, 85 202-203 (2015) [C3]
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2015 |
Verbeek DO, Sugrue M, Balogh Z, Cass D, Civil I, Harris I, et al., 'Erratum: Acute MANAGEMENT of HEMODYNAMICALLY UNSTABLE PELVIC TRAUMA PATIENTS: Time for a change? Multicenter review of recent practice', World Journal of Surgery, 38 2741 (2015) [O1]
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2015 |
McIlroy DJ, Bigland M, White AE, Hardy BM, Lott N, Smith DW, Balogh ZJ, 'Cell necrosis-independent sustained mitochondrial and nuclear DNA release following trauma surgery', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 78 282-288 (2015) [C1]
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2015 |
Duchesne JC, Kaplan LJ, Balogh ZJ, Malbrain MLNG, 'Role of permissive hypotension, hypertonic resuscitation and the global increased permeability syndrome in patients with severe haemorrhage: Adjuncts to damage control resuscitation to prevent intra-abdominal hypertension', Anaesthesiology Intensive Therapy, 47 143-155 (2015) [C1]
Secondary intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are closely related to fluid resuscitation. IAH causes major deterioration of the cardiac fun... [more]
Secondary intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are closely related to fluid resuscitation. IAH causes major deterioration of the cardiac function by affecting preload, contractility and afterload. The aim of this review is to discuss the different interactions between IAH, ACS and resuscitation, and to explore a new hypothesis with regard to damage control resuscitation, permissive hypotension and global increased permeability syndrome. The recognition of the association between the development of ACS and resuscitation urged the need for new approach in traumatic shock management. Over a decade after wide spread application of damage control surgery damage control resuscitation was developed. DCR differs from previous resuscitation approaches by attempting an earlier and more aggressive correction of coagulopathy, as well as metabolic derangements like acidosis and hypothermia, often referred to as the 'deadly triad' or the 'bloody vicious cycle'. Permissive hypotension involves keeping the blood pressure low enough to avoid exacerbating uncontrolled haemorrhage while maintaining perfusion to vital end organs. The potential detrimental mechanisms of early, aggressive crystalloid resuscitation have been described. Limitation of fluid intake by using colloids, hypertonic saline (HTS) or hyperoncotic albumin solutions have been associated with favourable effects. HTS allows not only for rapid restoration of circulating intravascular volume with less administered fluid, but also attenuates post-injury oedema at the microcirculatory level and may improve microvascular perfusion. Capillary leak represents the maladaptive, often excessive, and undesirable loss of fluid and electrolytes with or without protein into the interstitium that generates oedema. The global increased permeability syndrome (GIPS) has been articulated in patients with persistent systemic inflammation failing to curtail transcapillary albumin leakage and resulting in increasingly positive net fluid balances. GIPS may represent a third hit after the initial insult and the ischaemia reperfusion injury. Novel markers like the capillary leak index, extravascular lung water and pulmonary permeability index may help the clinician in guiding appropriate fluid management. Capillary leak is an inflammatory condition with diverse triggers that results from a common pathway that includes ischaemia-reperfusion, toxic oxygen metabolite generation, cell wall and enzyme injury leading to a loss of capillary endothelial barrier function. Fluid overload should be avoided in this setting.
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2015 |
Kirkpatrick AW, De Waele JJ, De Laet I, De Keulenaer B, D'Amours S, Björck M, et al., 'WSACS-The Abdominal Compartment Society. A Society dedicated to the study of the physiology and pathophysiology of the abdominal compartment and its interactions with all organ systems', Anaesthesiology Intensive Therapy, 47 191-194 (2015) [C3]
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2015 |
Lukins TR, Ferch R, Balogh ZJ, Hansen MA, 'Cervical spine immobilization following blunt trauma: a systematic review of recent literature and proposed treatment algorithm.', ANZ J Surg, 85 917-922 (2015) [C1]
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2015 |
Leppäniemi A, Kimball EJ, De Laet I, Malbrain MLNG, Balogh ZJ, De Waele JJ, 'Management of abdominal sepsis - A paradigm shift?', Anaesthesiology Intensive Therapy, 47 400-408 (2015) [C1]
The abdomen is the second most common source of sepsis and secondary peritonitis. The most common causes of abdominal sepsis are perforation, ischemic necrosis or penetrating inju... [more]
The abdomen is the second most common source of sepsis and secondary peritonitis. The most common causes of abdominal sepsis are perforation, ischemic necrosis or penetrating injury to the abdominal viscera. Management consists of control of the infection source, restoration of gastrointestinal tract (GI) function, systemic antimicrobial therapy and support of organ function. Mortality after secondary peritonitis is still high. Excluding patient-related factors such as age or co-morbidities that can not be influenced at the time of intervention, delay to surgical intervention and inability to obtain source control are the main determinants of outcome. In patients with severe physiological derangement or difficult intraperitoneal conditions, where a prolonged operation and complete anatomical repair may not be possible or appropriate, it is becoming increasingly popular to utilize a damage control strategy with abbreviated laparotomy and planned reoperations. The main components of damage control laparotomy for secondary peritonitis are postponing the reconstruction of intestinal anastomoses to a second operation (deferred anastomosis) and leaving the abdomen open with some form of temporary abdominal closure (TAC). Advances in the management techniques of the open abdomen and new negative pressure-based TAC-devices have significantly reduced the previously observed prohibitive morbidity associated with open abdomens. These advancements have led to current fascial closure rates after TAC approaching 90%. The cornerstones of appropriate antimicrobial therapy are the timing, spectrum and dosing of antibiotics. Enteral nutrition should be started as soon as possible in hemodynamically stable patients but withheld when the patient is on a significant dose of vasopressors or whenever GI hypoperfusion is suspected. Timely source control with appropriate use of antimicrobial agents and early intensive care offers the best chance of survival for patients with abdominal sepsis. The introduction of the concept of damage control to the management of secondary peritonitis represents a paradigm shift in the same way as in management of major trauma. Although limited and repeated surgical interventions have been shown to be safe, the actual benefits need to be demonstrated in controlled studies.
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2015 |
Kirkpatrick AW, Roberts DJ, Jaeschke R, De Waele JJ, De Keulenaer BL, Duchesne J, et al., 'Methodological background and strategy for the 2012-2013 updated consensus definitions and clinical practice guidelines from the abdominal compartment society.', Anaesthesiology intensive therapy, 47 Spec No s63-s77 (2015) [C1]
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2015 |
Gunning AC, Lansink KWW, Van Wessem KJP, Balogh ZJ, Rivara FP, Maier RV, Leenen LPH, 'Demographic Patterns and Outcomes of Patients in Level i Trauma Centers in Three International Trauma Systems', World Journal of Surgery, 39 2677-2684 (2015) [C1]
© 2015 The Author(s). Introduction: Trauma systems were developed to improve the care for the injured. The designation and elements comprising these systems vary across countries.... [more]
© 2015 The Author(s). Introduction: Trauma systems were developed to improve the care for the injured. The designation and elements comprising these systems vary across countries. In this study, we have compared the demographic patterns and patient outcomes of Level I trauma centers in three international trauma systems. Methods: International multicenter prospective trauma registry-based study, performed in the University Medical Center Utrecht (UMCU), Utrecht, the Netherlands, John Hunter Hospital (JHH), Newcastle, Australia, and Harborview Medical Center (HMC), Seattle, the United States. Inclusion: patients =18 years, admitted in 2012, registered in the institutional trauma registry. Results: In UMCU, JHH, and HMC, respectively, 955, 1146, and 4049 patients met the inclusion criteria of which 300, 412, and 1375 patients with Injury Severity Score (ISS) > 15. Mean ISS was higher in JHH (13.5; p < 0.001) and HMC (13.4; p < 0.001) compared to UMCU (11.7). Unadjusted mortality: UMCU = 6.5 %, JHH = 3.6 %, and HMC = 4.8 %. Adjusted odds of death: JHH = 0.498 [95 % confidence interval (CI) 0.303-0.818] and HMC = 0.473 (95 % CI 0.325-0.690) compared to UMCU. HMC compared to JHH was 1.002 (95 % CI 0.664-1.514). Odds of death patients ISS > 15: JHH = 0.507 (95 % CI 0.300-0.857) and HMC = 0.451 (95 % CI 0.297-0.683) compared to UMCU. HMC = 0.931 (95 % CI 0.608-1.425) compared to JHH. TRISS analysis: UMCU: Ws = 0.787, Z = 1.31, M = 0.87; JHH, Ws = 3.583, Z = 6.7, M = 0.89; HMC, Ws = 3.902, Z = 14.6, M = 0.84. Conclusion: This study demonstrated substantial differences across centers in patient characteristics and mortality, mainly of neurological cause. Future research must investigate whether the outcome differences remain with nonfatal and long-term outcomes. Furthermore, we must focus on the development of a more valid method to compare systems.
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2014 |
Butcher NE, D'Este C, Balogh ZJ, 'The quest for a universal definition of polytrauma: a trauma registry-based validation study.', J Trauma Acute Care Surg, 77 620-623 (2014) [C1]
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2014 |
Hirani R, Balogh ZJ, Lott NJ, Hsu JM, Irving DO, 'Leukodepleted blood components do not remove the potential for long-term transfusion-associated microchimerism in Australian major trauma patients.', Chimerism, 5 86-93 (2014)
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2014 |
Sartelli M, Catena F, Ansaloni L, Coccolini F, Corbella D, Moore EE, et al., 'Complicated intra-abdominal infections worldwide: The definitive data of the CIAOW Study', World Journal of Emergency Surgery, 9 (2014) [C1]
The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a... [more]
The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs).1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients.827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses.The overall mortality rate was 10.5% (199/1898).According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001). © 2014 Sartelli et al.; licensee BioMed Central Ltd.
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2014 |
Otomo Y, Holcomb JB, Mullins RJ, Bulger EM, Cohen MJ, Balogh Z, et al., 'Hemostatic resuscitation is neither hemostatic nor resuscitative in trauma hemorrhage DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 76 567-568 (2014) |
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2014 |
Arbabi S, Balogh Z, Froehlich MN, 'Epidemiology and risk factors of multiple-organ failure after multiple trauma: An analysis of 31,154 patients from the TraumaRegister DGU DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 76 927-927 (2014)
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2014 |
Neptune D, Bonevski B, Enninghorst N, Balogh ZJ, 'The prevalence of smoking and interest in quitting among surgical patients with acute extremity fractures', Drug and Alcohol Review, (2014) [C1]
Introduction and Aims: We studied the prevalence of smoking, the effect of hospital stay on motivation to quit and the exposure to smoking cessation advice in orthopaedic patients... [more]
Introduction and Aims: We studied the prevalence of smoking, the effect of hospital stay on motivation to quit and the exposure to smoking cessation advice in orthopaedic patients who required surgical intervention for acute extremity fractures. Design and Methods: This cross-sectional study involved a self-administered pen-and-paper survey assessing smoking status, interest and motivation to quit smoking, and current advice to quit among a consecutive cohort of patients aged 18-65 years old with acute extremity fractures. These patients were admitted to the John Hunter Hospital Level 1 trauma facility in New South Wales, Australia, for surgical intervention over a three month period. Results: A total of 183 patients (response rate 98%) completed the survey. Sixty-eight patients (37.2%) reported a current smoking habit. The prevalence of smoking was 42.2% among males and 25.5% among females. A total of 40% of smokers reported that they had not received advice to quit from medical staff during hospital admission. Prior to admission, 12.1% of smokers were interested in smoking cessation; this percentage increased to 26.8% post-admission. Discussion and Conclusions: The prevalence of smoking among surgical patients with extremity fractures was found to be more than twice the prevalence of the population of New South Wales. Hospital admission had a positive impact on the patient's interest in smoking cessation. Our study suggests that the identification of orthopaedic patients who smoke is suboptimal, and the opportunity to encourage smoking cessation during hospital admission is currently being overlooked. © 2014 Australasian Professional Society on Alcohol and other Drugs.
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2014 |
Weber DG, Bendinelli C, Balogh ZJ, 'Damage control surgery for abdominal emergencies', British Journal of Surgery, 101 (2014) [C1]
Background: Damage control surgery is a management sequence initiated to reduce the risk of death in severely injured patients presenting with physiological derangement. Damage co... [more]
Background: Damage control surgery is a management sequence initiated to reduce the risk of death in severely injured patients presenting with physiological derangement. Damage control principles have emerged as an approach in non-trauma abdominal emergencies in order to reduce mortality compared with primary definitive surgery. Methods: A PubMed/MEDLINE literature review was conducted of data available over the past decade (up to August 2013) to gain information on current understanding of damage control surgery for abdominal surgical emergencies. Future directions for research are discussed. Results: Damage control surgery facilitates a strategy for life-saving intervention for critically ill patients by abbreviated laparotomy with subsequent reoperation for delayed definitive repair after physiological resuscitation. The six-phase strategy (including damage control resuscitation in phase 0) is similar to that for severely injured patients, although non-trauma indications include shock from uncontrolled haemorrhage or sepsis. Minimal evidence exists to validate the benefit of damage control surgery in general surgical abdominal emergencies. The collective published experience over the past decade is limited to 16 studies including a total of 455 (range 3-99) patients, of which the majority are retrospective case series. However, the concept has widespread acceptance by emergency surgeons, and appears a logical extension from pathophysiological principles in trauma to haemorrhage and sepsis. The benefits of this strategy depend on careful patient selection. Damage control surgery has been performed for a wide range of indications, but most frequently for uncontrolled bleeding during elective surgery, haemorrhage from complicated gastroduodenal ulcer disease, generalized peritonitis, acute mesenteric ischaemia and other sources of intra-abdominal sepsis. Conclusion: Damage control surgery is employed in a wide range of abdominal emergencies and is an increasingly recognized life-saving tactic in emergency surgery performed on physiologically deranged patients. © 2013 BJS Society Ltd.
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2014 |
Easton R, Balogh ZJ, 'Peri-operative changes in serum immune markers after trauma: A systematic review', Injury, (2014) [C1]
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2014 |
Lumsdaine W, Easton RM, Lott NJ, White A, Malmanche TLD, Lemmert K, et al., 'Neutrophil oxidative burst capacity for peri-operative immune monitoring in trauma patients', Injury, (2014) [C1]
Background: Post injury immune dysfunction can result in serious complications. Measurement of biomarkers may guide the optimal timing of surgery in clinically borderline patients... [more]
Background: Post injury immune dysfunction can result in serious complications. Measurement of biomarkers may guide the optimal timing of surgery in clinically borderline patients and therefore prevent complications. Aim: peri-operative measurement of neutrophil oxidative burst capacity as an indicator of the immune response to major orthopaedic surgical procedures. Methods: Prospective cohort study of trauma patients aged =16 yrs with pelvic, acetabular, femoral shaft or tibial shaft fractures requiring surgical intervention. Blood samples were taken immediately pre-op and at 30 min, 7, 24 and 72-96 h post-operatively. Neutrophil oxidative burst capacity was measured both with and without stimulation by formyl-methionyl-leucyl-phenylalanine (fMLP, a chemotactic factor). Clinical outcomes measured were mortality, length of stay, MOF, pneumonia, acute respiratory distress syndrome (ARDS) and sepsis. Results: 100 consecutive orthopaedic trauma patients were enrolled over a 16 month period. 78% were male, with a mean age of 42 ± 18 years and an average ISS of 19 ± 13. Neutrophil oxidative burst capacity was significantly elevated at 7 h (p = 0.006) and 24 h (p = 0.022) post operatively. Patients who developed infective complications (pneumonia and sepsis) had higher levels of oxidative burst capacity pre-operatively (pneumonia: 1.52 ± 0.93 v 0.99 ± 0.66 p = 0.032, sepsis: 1.39 ± 0.86 v 0.97 ± 0.56 p = 0.024) and at 24 h post op (pneumonia: 2.72 ± 2.38 v 1.12 ± 0.63 p = <0.001, sepsis: 2.16 ± 2.09 v 1.10 ± 0.54 p = <0.001). When analysed by operation type, no statistical difference was seen between major and minor operations. No correlation was found between length of stay, length of ICU stay, ISS or age and neutrophil oxidative burst capacity at any time point. Conclusions: Neutrophil oxidative burst capacity response to orthopaedic trauma surgery is associated with the infective post injury complications. There was no correlation between magnitude of injury or operation and oxidative burst capacity. These results are promising for the development of tools for prediction of post-operative complications and guidance for optimal timing for surgical intervention. © 2014 Elsevier Ltd. All rights reserved.
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2014 |
Tay W-H, de Steiger R, Richardson M, Gruen R, Balogh ZJ, 'Health outcomes of delayed union and nonunion of femoral and tibial shaft fractures', Injury, (2014) [C1]
Introduction: Knowledge about the functional consequences of lower limb long bone fractures is helpful to inform patients, clinicians and employers about their recovery process an... [more]
Introduction: Knowledge about the functional consequences of lower limb long bone fractures is helpful to inform patients, clinicians and employers about their recovery process and prognosis. This study aims to describe the epidemiology and health outcomes of femoral and tibial shaft fractures treated at two level I trauma centres, by comparing the differences between patients with delayed union or nonunion and patients with union. Patients and methods: An analysis of registry data over two years, supplemented with medical record review, was conducted. Fracture healing was retrospectively assessed by clinical and radiological evidence of union, and the need for surgical intervention. SF-12 scores, and work and pain status were prospectively recorded at six and twelve months post injury. Results: 285 fractures progressed to union and 138 fractures developed delayed union or nonunion. There was a significant difference between the two cohorts with regards to the mechanism of injury, association with multi-trauma, open fractures, grade of Gustilo classification, patient fund source, smoking status and presence of comorbidities. The SF-12 physical component score was less than 50 at both six and twelve months with improvement in the union group, but not in the delayed union or nonunion group. 72% of patients with union had returned to work at one year, but 54% continued to have pain. The difference compared to patients with delayed union or nonunion was significant. Discussion: Even patients whose fractures unite in the expectant time-frame will have residual physical disability. Patients with delayed union or nonunion have still poorer outcomes, including ongoing problems with returning to work and pain. It is important to educate patients about their injury so that they have realistic expectations. This is particularly relevant given that the patients most likely to sustain femoral or tibial shaft fractures are working-age healthy adults, and up to a third of fractures may develop delayed union or nonunion. Conclusion: Despite modern treatment, the patient-reported outcomes of lower limb long bone shaft fractures do not return to normal at one year. Patients with delayed union or nonunion can expect poorer outcomes. © 2014 Elsevier Ltd. All rights reserved.
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Balogh ZJ, Lumsdaine W, Moore EE, Moore FA, 'Postinjury abdominal compartment syndrome: from recognition to prevention', LANCET, 384 1466-1475 (2014) [C1]
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2014 |
Verbeek DO, Sugrue M, Balogh Z, Cass D, Civil I, Harris I, et al., 'Erratum to: Acute Management of Hemodynamically Unstable Pelvic Trauma Patients: Time for a Change? Multicenter Review of Recent Practice', World Journal of Surgery, (2014) [O1]
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2014 |
McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery', Journal of Critical Care, 29 1133.e1-1133.e5 (2014) [C1]
© 2014 The Authors. Introduction: Neutrophil extracellular traps (NETs) have not been demonstrated after trauma and subsequent surgery. Neutrophil extracellular traps are formed f... [more]
© 2014 The Authors. Introduction: Neutrophil extracellular traps (NETs) have not been demonstrated after trauma and subsequent surgery. Neutrophil extracellular traps are formed from pure mitochondrial DNA (mtDNA) under certain conditions, which is potently proinflammatory. We hypothesized that injury and orthopedic trauma surgery would induce NET production with mtDNA as a structural component. Methods: Neutrophils were isolated 8 trauma patients requiring orthopedic surgery postinjury and up to 5 days postoperatively. Four healthy volunteers provided positive and negative controls. Total hip replacement patients acted as an uninjured surgical control group. Neutrophil extracellular traps were visualized with DNA (Hoechst 33342TM/Sytox Green/MitoSox/MitoTracker) stains using live cell fluorescence microscopy with downstream quantitative polymerase chain reaction analysis of DNA composition. Results: Neutrophil extracellular traps were present after injury in all 8 trauma patients. They persisted for 5 days postoperatively. Delayed surgery resulted in NET resolution, but they reformed postoperatively. Total hip replacement patients developed NETs postoperatively, which resolved by day 5. Quantitative polymerase chain reaction analysis of NET-DNA composition revealed that NETs formed after injury and surgery were made of mtDNA with no detectable nuclear DNA component. Conclusions: Neutrophil extracellular traps formed after major trauma and subsequent surgery contain mtDNA and represent a novel marker of heightened innate immune activation. They could be considered when timing surgery after trauma to prevent systemic NET-induced inflammatory complications.
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2014 |
Toth L, King KL, McGrath B, Balogh ZJ, 'Factors associated with pelvic fracture-related arterial bleeding during trauma resuscitation: A prospective clinical study', Journal of Orthopaedic Trauma, 28 489-495 (2014) [C1]
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2014 |
Balogh ZJ, 'Trauma verification: for the trauma centre or for the trauma system?', ANZ JOURNAL OF SURGERY, 84 499-500 (2014) [C3]
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2014 |
Tarrant SM, Hardy BM, Balogh ZJ, 'Repair of traumatic muscle herniation with acellular porcine collagen matrix', ANZ Journal of Surgery, 84 464-467 (2014) [C1]
Background: Muscle hernias are uncommon clinical conditions with no uniform solution of repair. Biocompatible mesh allows for repair of hernias without the donor site morbidity an... [more]
Background: Muscle hernias are uncommon clinical conditions with no uniform solution of repair. Biocompatible mesh allows for repair of hernias without the donor site morbidity and complications from direct repair under tension. Methods: Over a 6-month period at a Level 1 Trauma centre, four consecutive symptomatic muscle hernias were identified, two in the forearm and two in the lower limb. Three resulted from high-speed motorbike accidents, one from a mining accident. All patients had hernia repair at a minimum of 4 months post accident. A 10×15cm×1.0mm sheet of acellular collagen matrix was fashioned to fit as an underlay of the fascia defect. Patients were clinically followed at the 2-, 6-, 12- and 26-week mark. Final phone contact was made 18 months post-operatively. Results: All patients were pleased with their cosmetic and functional outcomes. All patients returned to work and sport 3 months after reconstruction. Conclusion: Symptomatic hernias as a result of trauma can be safely reconstructed with a biological mesh implant. This approach can prevent complications from previously described methods and return to active lifestyles with good results. © 2013 Royal Australasian College of Surgeons.
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2014 |
Tarrant SM, Hardy BM, Byth PL, Brown TL, Attia J, Balogh ZJ, 'Preventable mortality in geriatric hip fracture inpatients', Bone and Joint Journal, 69B 1178-1184 (2014) [C1]
© 2014 The British Editorial Society of Bone & Joint Surgery. There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine ... [more]
© 2014 The British Editorial Society of Bone & Joint Surgery. There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management of these patients. A 12 month prospective study was performed on patients aged > 65 years who had sustained a fracture of the hip. This was conducted at a Level 1 Trauma Centre with no orthogeriatric service. A multidisciplinary review of the medical records by four specialists was performed to analyse errors of management and elements of preventable mortality. During 2011, there were 437 patients aged > 65 years admitted with a fracture of the hip (85 years (66 to 99)) and 20 died while in hospital (86.3 years (67 to 96)). A total of 152 errors were identified in the 80 individual reviews of the 20 deaths. A total of 99 errors (65%) were thought to have at least a moderate effect on death; 45 reviews considering death (57%) were thought to have potentially been preventable. Agreement between the panel of reviewers on the preventability of death was fair. A larger-scale assessment of preventable mortality in elderly patients who sustain a fracture of the hip is required. Multidisciplinary review panels could be considered as part of the quality assurance process in the management of these patients.
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2014 |
Butcher NE, Balogh ZJ, 'Update on the definition of polytrauma', European Journal of Trauma and Emergency Surgery, (2014) [C1]
Purpose The definition and use of the term "polytrauma" is inconsistent and lacks validation. This article describes the historical evolution of the term and geographica... [more]
Purpose The definition and use of the term "polytrauma" is inconsistent and lacks validation. This article describes the historical evolution of the term and geographical differences in its meaning, examines the challenges faced in defining it adequately in the current context, and summarizes where the international consensus process is heading, in order to provide the trauma community with a validated and universally agreed upon definition of polytrauma. Conclusion A lack of consensus in the definition of "polytrauma" was apparent. According to the international consensus opinion, both anatomical and physiological parameters should be included in the definition of polytrauma. An Abbreviated Injury Scale (AIS) based anatomical definition is the most practical and feasible given the ubiquitous use of the system. Convincing preliminary data show that two body regions with AIS >2 is a good marker of polytrauma-better than other ISS cutoffs, which could also indicate monotrauma. The selection of the most accurate physiological parameters is still underway, but they will most likely be descriptors of tissue hypoxia and coagulopathy. © 2014 Springer-Verlag Berlin Heidelberg.
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2014 |
Cryer HG, Rhee P, Dr H, Balogh ZJ, Sauaia A, 'Temporal trends of postinjury multiple-organ failure: Still resource intensive, morbid, and lethal DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 76 592-593 (2014) [C1]
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2014 |
White AE, Edelman JJB, Lott N, Bannon PG, McElduff P, Curnow JL, Balogh ZJ, 'Characterization of the hypercoagulable state following severe orthopedic trauma', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 77 231-237 (2014) [C1]
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2014 |
Pape H-C, Lefering R, Butcher N, Peitzman A, Leenen L, Marzi I, et al., 'The definition of polytrauma revisited: An international consensus process and proposal of the new 'Berlin definition'', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 77 780-786 (2014) [C1]
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2014 |
Dewar DC, White A, Attia J, Tarrant SM, King KL, Balogh ZJ, 'Comparison of postinjury multiple-organ failure scoring systems: Denver versus sequential organ failure assessment', Journal of Trauma and Acute Care Surgery, 77 624-629 (2014) [C1]
Copyright © 2014 by Lippincott Williams & Wilkins. BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidemi... [more]
Copyright © 2014 by Lippincott Williams & Wilkins. BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidemiology of postinjury multiple-organ failure; however, differences in these scores make it difficult to compare incidence, duration, and mortality of multiple-organ failure. The study aim was to compare the performance of the Denver and SOFA scores with respect to the outcomes of mortality, intensive care unit length of stay (ICU LOS), and ventilator days.METHODS: A 60-month prospective epidemiologic study was undertaken at an Australian Level I trauma center. Data were collected on trauma patients that met inclusion criteria (ICU admission, Injury Severity Score [ISS] 9 15, age 9 18 years, head Abbreviated Injury Scale [AIS] score G 3, survival for 948 hours). Demographics, ISS, physiologic parameters, SOFA and Denver scores, and outcome data were prospectively collected. Sensitivity/specificity and receiver operating characteristic curve were calculated for both scores. Analysis was also completed for a Day 3 postinjury SOFA and Denver score.RESULTS: A total of 140 patients met the inclusion criteria (mean [SD] age, 47 [21] years; ISS, 30; male, 69%; mortality rate, 6%; mean [SD] ICU LOS, 9 [7] days; mean [SD] ventilation period, 6 [7] days). There was no difference in the score performance predicting mortality. Day 3 SOFA score of 4 or greater outperformed the Denver score of greater than 3 when predicting ICU LOS and ventilator days (area under the curve, 0.83 vs. 0.69, 0.86 vs. 0.73, respectively). The SOFA score was more sensitive and the Denver score was more specific when predicting mortality, ICU LOS, and ventilator days.CONCLUSION: Both scores had similar performance predicting mortality; however, the Day 3 SOFA score outperforms the Denver score when predicting ICU LOS and ventilator days. Either score could be superior based on whether one is seeking to optimize specificity or sensitivity. It is important to note that these findings are in a non-head-injured population and that there are practical difficulties using the SOFA in head-injured patients.LEVEL OF EVIDENCE: Diagnostic study, level II.
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Balogh ZJ, 'Publishing trauma-related topics in ANZ Journal of Surgery.', ANZ J Surg, 84 399-400 (2014) [C3]
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2013 |
Burge K, Young D, 'Striving for excellence', MEDICAL JOURNAL OF AUSTRALIA, 198 C5-C5 (2013) |
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2013 |
Burge K, Shymko G, 'Mind matters Dr Gordon Shymko reflects on his career in psychiatry', MEDICAL JOURNAL OF AUSTRALIA, 198 C5-C5 (2013) |
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2013 |
Bendinelli C, Bivard A, Nebauer S, Parsons MW, Balogh ZJ, 'Brain CT perfusion provides additional useful information in severe traumatic brain injury', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 1208-1212 (2013) [C1]
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2013 |
Sartelli M, Catena F, Ansaloni L, Moore E, Malangoni M, Velmahos G, et al., 'Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)', WORLD JOURNAL OF EMERGENCY SURGERY, 8 (2013) [C1]
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2013 |
Sartelli M, Viale P, Catena F, Ansaloni L, Moore E, Malangoni M, et al., '2013 WSES guidelines for management of intra-abdominal infections', WORLD JOURNAL OF EMERGENCY SURGERY, 8 (2013) [C2]
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2013 |
Butcher NE, Balogh ZJ, 'The practicality of including the systemic inflammatory response syndrome in the definition of polytrauma: Experience of a level one trauma centre', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 12-17 (2013) [C1]
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2013 |
Lumsdaine W, Enninghorst N, Hardy BM, Balogh ZJ, 'Patterns of CT use and surgical intervention in upper limb periarticular fractures at a level-1 trauma centre', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 471-474 (2013) [C1]
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2013 |
Sisak K, Manolis M, Hardy BM, Enninghorst N, Bendinelli C, Balogh ZJ, 'Acute transfusion practice during trauma resuscitation: Who, when, where and why?', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 581-586 (2013) [C1]
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2013 |
Soederlund T, Yoshino O, Bendinelli C, Enninghorst N, Balogh ZJ, 'Acute repair of traumatic abdominal muscle avulsion from iliac crest: A mesh-free technique using suture anchors', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 1257-1259 (2013) [C3]
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2013 |
Burge K, Balogh Z, 'Striving for excellence', MEDICAL JOURNAL OF AUSTRALIA, 198 C5-C5 (2013) [C3] |
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2013 |
Hunt JJ, Lumsdaine W, Attia J, Balogh ZJ, 'AO type-C distal radius fractures: the influence of computed tomography on surgeon's decision-making', ANZ JOURNAL OF SURGERY, 83 676-678 (2013) [C3]
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2013 |
Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain MLNG, De Keulenaer B, et al., 'Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome', INTENSIVE CARE MEDICINE, 39 1190-1206 (2013) [C1]
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2013 |
Balogh ZJ, McIlroy DJ, Smith DW, Hansbro PM, 'The origin and the role of mitochondrial DNA in postinjury inflammation', Journal of Critical Care, 28 1099-1100 (2013) [C3]
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2013 |
Sisak K, Manolis M, Hardy BM, Enninghorst N, Balogh ZJ, 'Epidemiology of Acute Transfusions in Major Orthopaedic Trauma', JOURNAL OF ORTHOPAEDIC TRAUMA, 27 413-418 (2013) [C1]
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2013 |
Mitchell RJ, Curtis K, Holland AJ, Balogh ZJ, Evans J, Wilson KL, 'Acute costs and predictors of higher treatment costs for major paediatric trauma in New South Wales, Australia', Journal of Paediatrics and Child Health, 49 557-563 (2013) [C1]
Aims To describe the costs of acute trauma admissions for children aged =15 years in trauma centres; to identify predictors of higher treatment costs and quantify differences in a... [more]
Aims To describe the costs of acute trauma admissions for children aged =15 years in trauma centres; to identify predictors of higher treatment costs and quantify differences in actual and state-wide average cost in New South Wales (NSW), Australia. Method Admitted trauma patient data provided by 12 trauma centres was linked with financial data for 2008-2009. Demographic, injury details and injury severity scores (ISS) were obtained from trauma registries. Individual patient costs, Australian Refined Diagnostic Related Groups (AR-DRG) and state-wide average costs were obtained. Actual costs incurred by each hospital were compared with state-wide AR-DRG average costs. Multivariate multiple linear regression identified predictors of cost. Results There were 3493 patients with a total cost of AUD$20.2 million. Falls (AUD$6.7 million) and road trauma (AUD$4.4 million) had the highest total expenditure. The reduction in cost between ISS < 9 compared to ISS 9-12 and ISS > 12 was significant (P < 0.0001). The median cost of injury increased with every additional body region injured (P < 0.0001). For each additional day spent in hospital, there was an increased cost of AUD$1898 and patients admitted to an intensive care unit (ICU) cost AUD$7358 more than patients not admitted to ICU. The total costs incurred by trauma centres were AUD$1.4 million above the NSW peer group average cost estimates. Conclusions The high financial cost of paediatric patient treatment highlights the need to ensure prevention remains a priority in Australia. Hospitals tasked with providing trauma care should be appropriately funded and future funding models should consider trauma severity. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
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Balogh ZJ, 'Severe trauma in elderly patients', ANZ JOURNAL OF SURGERY, 83 2-3 (2013) [C3]
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2013 |
Balogh ZJ, Fischer A, 'Potential preventive measures against quad bike injuries', ANZ JOURNAL OF SURGERY, 83 198-198 (2013) [C3]
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2013 |
Balogh ZJ, Balogh R, 'Practical Management of Head and Neck Injury. Edited by J. V. Rosenfeld . Sydney: Churchill Livingstone, 2012. Illustrations: \ 250 colour and black and whites. Page count: XII and 389 pages. ISBN 9780729539562. Price: $150.00.', ANZ JOURNAL OF SURGERY, 83 393-393 (2013) [C3]
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2013 |
O'Reilly-Harbidge SC, Balogh ZJ, 'Three-point suture anchor repair of traumatic sternoclavicular joint dislocation', ANZ JOURNAL OF SURGERY, 83 883-886 (2013) [C1]
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2013 |
Hardy BM, Chan S, Martin AB, Brieva J, Gallagher A, Sokolowsky A, Balogh ZJ, 'Temperature change in the helicopter transport of trauma patients', ANZ JOURNAL OF SURGERY, 83 894-895 (2013) [C3]
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2013 |
Balogh ZJ, Weber DG, 'Polytrauma and Organ Crosstalk', ICU Management, 13 - (2013) [C3] |
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2013 |
Mitchell RJ, Bambach MR, Muscatello D, McKenzie K, Balogh ZJ, 'Can SNOMED CT as implemented in New South Wales, Australia be used for road trauma injury surveillance in emergency departments?', Health Information Management Journal, 42 4-8 (2013) [C1]
The introduction of Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT) for diagnosis coding in emergency departments (EDs) in New South Wales (NSW) has implication... [more]
The introduction of Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT) for diagnosis coding in emergency departments (EDs) in New South Wales (NSW) has implications for injury surveillance abilities. This study aimed to assess the consequences of its introduction, as implemented as part of the ED information system in NSW, for identifying road trauma-related injuries in EDs. It involved a retrospective analysis of road trauma-related injuries identified in linked police, ED and mortality records during March 2007 to December 2009. Of all SNOMED CT codes in the principal provisional diagnosis field, between 53.7% and 78.4% referred to the type of injury or symptom experienced by the individual. Of the road users identified by police, 3.2% of vehicle occupants, 6% of motorcyclists, 10.0% of pedal cyclists and 5.2% of pedestrians were identified using SNOMED CT codes in the principal provisional diagnosis field. The introduction of SNOMED CT may provide flexible terminologies for clinicians. However, unless carefully implemented in information systems, its flexibility can lead to mismatches between the intention and actual use of defined data fields. Choices available in SNOMED CT to indicate symptoms, diagnoses, or injury mechanisms need to be controlled and these three concepts need to be retained in separate data fields to ensure a clear distinction between their classifications in the ED.
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2013 |
Williams N, Hardy BM, Tarrant S, Enninghorst N, Attia J, Oldmeadow C, Balogh ZJ, 'Changes in hip fracture incidence, mortality and length of stay over the last decade in an Australian major trauma centre.', Archives of Osteoporosis, 8 (2013) [C1]
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2013 |
Enninghorst N, Hardy BM, Sisak K, Lott N, Balogh ZJ, 'Tissue oxygen saturation changes during intramedullary nailing of lower-limb fractures', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 123-127 (2013) [C1]
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2013 |
Dewar DC, Tarrant SM, King KL, Balogh ZJ, 'Changes in the epidemiology and prediction of multiple-organ failure after injury', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 774-779 (2013) [C1]
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2013 |
Wong TH, Lumsdaine W, Hardy BM, Balogh ZJ, 'The impact of specialist trauma service on major trauma mortality', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 780-784 (2013) [C1]
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2013 |
Butcher NE, Enninghorst N, Sisak K, Balogh ZJ, 'The definition of polytrauma: Variable interrater versus intrarater agreement-A prospective international study among trauma surgeons', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 884-889 (2013) [C1]
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2013 |
Enninghorst N, McDougall D, Evans JA, Sisak K, Balogh ZJ, 'Population-based epidemiology of femur shaft fractures', Journal of Trauma and Acute Care Surgery, 74 1516-1520 (2013) [C1]
BACKGROUND: Themanagement of patientswith femoral shaft fractures (FSFs) is often a decisionmaking dilemma (damage-control orthopedics vs. early total care), with equivocal eviden... [more]
BACKGROUND: Themanagement of patientswith femoral shaft fractures (FSFs) is often a decisionmaking dilemma (damage-control orthopedics vs. early total care), with equivocal evidence. The comprehensive, population-based epidemiology of patients with FSF is unknown. The purpose of this prospective study was to describe the epidemiology of patientswith FSF, with special focus on patient physiology and timing of surgery. METHODS: A 12-month prospective population-based study was performed on consecutive patients with FSF in an area with 850,000 population including all ages and prehospital deaths. Patient demographics, mechanism, Injury Severity Score (ISS), shock parameters (systolic blood pressure, base deficit and lactate), transfusion requirement, fracture type [Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association classification (OA/OTA)], comorbidities, procedures, and outcomes were recorded. Patients hemodynamic status was described as stable, borderline, unstable, and "in extremis." RESULTS: Atotal of 126 patients (21 per 100,000 per year)with 136 femur fractures (62%male; age, 38 [28] years; ISS, 20 [19]; 51%multiple injuries) were identified in the region. Sixty patients (48.4%) sustained a high-energy injury with 19 (31.1%) of these being polytrauma patients (ISS, 28 [12]; systolic blood pressure, 98 [39]; base deficit, 6.5 [5.8]; lactate 4 [2]).Fifteen polytrauma patients (94%) required massive transfusion (12 [12] U of packed red blood cells, 8 [5] fresh frozen plasma, 1 [0.4] platelet, 13 [8] cryoprecipitate). Twenty-one patients (16.7%) died at the prehospital setting (3.5 per 100,000 per year). From the 105 hospital admissions, 68.3% was stable (14.3 per 100,000 per year), 8.7% was borderline (1.8 per 100,000 per year), 4.0% was unstable (0.8 per 100,000 per year) and 2.4%(0.5 per 100,000 per year)was in extremis. Six patients (5.7%) died. The length of stay (LOS) was 18 (15) days, and the intensive care unit LOS was 5 (6) days. Fourty-five patients sustained a low-energy injury that had in 85%of casesmultiple comorbidities. Eight low-energy patients needed 3 (1) transfusions, and none of the patients died. The LOS was 15 (11) days. CONCLUSION: Patients with low-energy FSF have a hospital admission rate similar to the patients with high-energy FSF. Sixty-eight percent of patients with FSF are complicated (open, compromised physiology, multiple injuries, bilateral, elderly with comorbidities, etc.), requiring major resources and highly specialized care. LEVEL OF EVIDENCE: Epidemiology study, level III. Copyright © 2013 Lippincott Williams & Wilkins.
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2012 |
Butcher NE, Balogh ZJ, 'AIS \ 2 in at least two body regions: A potential new anatomical definition of polytrauma', Injury, 43 196-199 (2012) [C1]
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2012 |
Van Wessem KJP, Mackay PJ, King KL, Balogh ZJ, 'Selective faecal diversion in open pelvic fractures: Reassessment based on recent experience', Injury-International Journal of the Care of the Injured, 43 522-525 (2012) [C3]
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2012 |
Toth L, King KL, McGrath B, Balogh ZJ, 'Efficacy and safety of emergency non-invasive pelvic ring stabilisation', Injury: International Journal of the Care of the Injured, 43 1330-1334 (2012) [C1]
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2012 |
Easton RM, Bendinelli C, Sisak K, Enninghorst N, Regan D, Evans J, Balogh ZJ, 'Recalled pain scores are not reliable after acute trauma', Injury: International Journal of the Care of the Injured, 43 1029-1032 (2012) [C1]
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2012 |
Koller H, Balogh ZJ, 'Single training session for first time pelvic C-clamp users: Correct pin placement and frame assembly', Injury: International Journal of the Care of the Injured, 43 436-439 (2012) [C1]
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2012 |
Yoshino O, Quail AW, Oldmeadow CJ, Balogh ZJ, 'The interpretation of intra-abdominal pressures from animal models: The rabbit to human example', Injury: International Journal of the Care of the Injured, 43 169-173 (2012) [C1]
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2012 |
Curtis KA, Mitchell RJ, Chong SS, Balogh ZJ, Reed DJ, Clark PT, et al., 'Injury trends and mortality in adult patients with major trauma in New South Wales', Medical Journal of Australia, 197 233-237 (2012) [C1]
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2012 |
Gruen RL, Brohi K, Schreiber M, Balogh ZJ, Pitt V, Narayan M, Maier RV, 'Haemorrhage control in severely injured patients', Lancet, 380 1099-1108 (2012) [C1]
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2012 |
Balogh ZJ, Reumann MK, Gruen RL, Mayer-Kuckuk P, Schuetz MA, Harris IA, et al., 'Advances and future directions for management of trauma patients with musculoskeletal injuries', Lancet, 380 1109-1119 (2012) [C1]
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2012 |
Puchwein P, Enninghorst N, Sisak K, Ortner T, Schildhauer TA, Balogh ZJ, Pichler W, 'Percutaneous fixation of acetabular fractures: Computer-assisted determination of safe zones, angles and lengths for screw insertion', Archives of Orthopaedic and Trauma Surgery, 132 805-811 (2012) [C1]
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2012 |
Sisak K, Soeyland K, McLeod MG, Jansen M, Enninghorst N, Martin A, Balogh ZJ, 'Massive transfusion in trauma: Blood product ratios should be measured at 6 hours', ANZ Journal of Surgery, 82 161-167 (2012) [C1]
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2012 |
Easton RM, Sisak K, Balogh ZJ, 'Time to computed tomography scanning for major trauma patients: The Australian reality', ANZ Journal of Surgery, 82 644-647 (2012) [C1]
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2012 |
Alrahbi R, Easton RM, Bendinelli C, Enninghorst N, Sisak K, Balogh ZJ, 'Intercostal catheter insertion: Are we really doing well?', ANZ Journal of Surgery, 82 392-394 (2012) [C1]
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2012 |
Bendinelli C, Martin A, Nebauer SD, Balogh ZJ, 'Strangulated intercostal liver herniation subsequent to blunt trauma. First report with review of the world literature', World Journal of Emergency Surgery, 7 23 (2012) [C3]
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2012 |
Pape HC, Balogh ZJ, 'Physician involvement in the care of multiply injured patients: The role of guidelines and subspecialties', European Journal of Trauma and Emergency Surgery, 38 209-210 (2012) [C3] |
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2012 |
Hofman M, Sellei R, Peralta R, Balogh ZJ, Wong TH, Evans JA, et al., 'Trauma systems: Models of prehospital and inhospital care', European Journal of Trauma and Emergency Surgery, 38 253-260 (2012) [C1]
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2012 |
Livingston D, Gilani R, Balogh Z, Burlew CC, Thorson CM, 'Operating room or angiography suite for hemodynamically unstable pelvic fractures? DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 72 371-372 (2012) [C3]
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2012 |
Barquist E, Lucas CE, Cohen MJ, Balogh ZJ, Wohlauer MV, 'Acute kidney injury and posttrauma multiple organ failure: The canary in the coal mine DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 72 379-380 (2012) [C3]
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2012 |
Arnold TDW, Balogh ZJ, 'Re: Bland-Altman plot agreement: It is time to stop the stab', Journal of Trauma and Acute Care Surgery, 72 1452-1453 (2012) [C3] |
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2012 |
Easton RM, Bendinelli C, Sisak K, Enninghorst N, Balogh ZJ, 'Prehospital nausea and vomiting after trauma: Prevalence, risk factors, and development of a predictive scoring system', Journal of Trauma and Acute Care Surgery, 72 1249-1253 (2012) [C1]
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2011 |
Balogh ZJ, Pape HC, 'The challenges and advances of polytrauma care in 2012', European Journal of Trauma and Emergency Surgery, 37 537-538 (2011) [C3] |
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2011 |
Sisak K, Dewar D, Butcher N, King K, Evans J, Miller M, et al., 'The treatment of traumatic shock: Recent advances and unresolved questions', European Journal of Trauma and Emergency Surgery, 37 567-575 (2011) [C1]
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2011 |
Enninghorst N, Peralta R, Yoshino O, Pfeifer R, Pape HC, Hardy BM, et al., 'Physiological assessment of the polytrauma patient: initial and secondary surgeries', European Journal of Trauma and Emergency Surgery, 37 559-566 (2011) [C1]
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2011 |
Dewar D, Balogh ZJ, 'The epidemiology of multiple-organ failure: A definition controversy', Acta Anaesthesiologica Scandinavica, 55 248-249 (2011) [C3]
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2011 |
Balogh ZJ, Leppaniemi A, 'Patient populations at risk for intra-abdominal hypertension and abdominal compartment syndrome', American Surgeon, 77 S12-S16 (2011) [C1]
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2011 |
Balogh ZJ, Malbrain M, 'Resuscitation in intra-abdominal hypertension and abdominal compartment syndrome', American Surgeon, 77 S31-S33 (2011) [C1]
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2011 |
Balogh ZJ, Martin A, Van Wessem KP, King KL, Mackay P, Havill K, 'Mission to eliminate postinjury abdominal compartment syndrome', Archives of Surgery, 146 938-943 (2011) [C1]
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2011 |
Harrigan PW, Balogh ZJ, 'Quality trauma research and major trauma registries', Injury, 42 38-39 (2011) [C3]
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2011 |
Davis KA, Knudson MM, Shackford SR, Balogh Z, Tinkoff G, Shapiro M, Forsythe RM, 'Discussion', Journal of Trauma - Injury, Infection and Critical Care, 70 1386-1388 (2011)
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2011 |
Cohen MJ, Lottenberg L, Cryer HG, Balogh Z, Moore EE, Kaplan LJ, Cotton BA, 'Rapid Thrombelastography Delivers Real-Time Results That Predict Transfusion Within 1 Hour of Admission DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 71 414-417 (2011) [C3]
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2011 |
Arnold TDW, Miller MK, Van Wessem KP, Evans JA, Balogh ZJ, 'Base deficit from the first peripheral venous sample: A surrogate for arterial base deficit in the trauma bay', Journal of Trauma - Injury, Infection and Critical Care, 71 793-797 (2011) [C1]
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2011 |
Balogh ZJ, 'Editorial comment', Journal of Trauma - Injury, Infection and Critical Care, 71 590 (2011) [C3]
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2011 |
Enninghorst N, McDougall D, Hunt JJ, Balogh ZJ, 'Open tibia fractures: Timely debridement leaves injury severity as the only determinant of poor outcome', Journal of Trauma-Injury Infection and Critical Care, 70 352-356 (2011) [C1]
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2011 |
Bhandari M, Guyatt G, Jeray K, Balogh ZJ, King KL, Flow Investigators, 'Fluid lavage of open wounds (FLOW): A multicenter, blinded, factorial pilot trial comparing alternative irrigating solutions and pressures in patients with open fractures', Journal of Trauma-Injury Infection and Critical Care, 71 596-606 (2011) [C1]
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2011 |
Balogh ZJ, 'Traumatic shock resuscitation with a 1:1 plasma to packed red blood cell ratio: Is it to please ourselves or the injured?', Critical Care Medicine, 39 1597-1598 (2011) [C3]
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2011 |
Crash-2 Collaborators, Balogh ZJ, 'The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial', The Lancet, 377 1096.e2-1101.e2 (2011) [C1]
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2011 |
Nicholas B, Toth L, Van Wessem K, Evans J, Enninghorst N, Balogh ZJ, 'Borderline femur fracture patients: Early total care or damage control orthopaedics?', ANZ Journal of Surgery, 81 148-153 (2011) [C1]
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2011 |
Fick AEA, Raychaudhuri P, Bear J, Roy G, Balogh ZJ, Kumar R, 'Factors predicting the need for splenectomy in children with blunt splenic trauma', ANZ Journal of Surgery, 81 717-719 (2011) [C1]
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2011 |
Balogh ZJ, 'Solutions for complex upper extremity trauma', ANZ Journal of Surgery, 81 567-568 (2011) [C3] |
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2011 |
Dewar D, Butcher NE, King KL, Balogh ZJ, 'Post injury multiple organ failure', Trauma, 13 81-91 (2011) [C1]
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2010 |
Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, et al., 'Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial', LANCET, 376 23-32 (2010) [C1]
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2010 |
De Waele JJ, Cheatham ML, Balogh ZJ, Bjorck M, D'Amours S, De Keulenaer B, et al., 'Intra-abdominal pressure measurement using a U-Tube technique: Caveat emptor', Annals of Surgery, 252 890-891 (2010) [C3]
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2010 |
Balogh ZJ, Martin AB, 'Prospective cohorts and risk adjusted outcomes for trauma', Injury-International Journal of the Care of the Injured, 41S 24-26 (2010) [C2]
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2010 |
Balogh ZJ, Wiles CE, Mullins R, Bosse MJ, 'Skeletal Traction Versus External Fixation in the Initial Temporization of Femoral Shaft Fractures in Severely Injured Patients DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 68 638-639 (2010) [C3] |
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2010 |
Hoyt DB, Balogh ZJ, Kozar RA, Cook A, 'Acute Definitive Internal Fixation of Pelvic Ring Fractures in Polytrauma Patients: A Feasible Option DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 68 939-941 (2010) [C3] |
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2010 |
Coimbra R, Billiar TR, Balogh Z, Poggetti RS, Huynh TT, 'Reducing Leukocyte Trafficking Preserves Hepatic Function After Sepsis DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 69 366-367 (2010) [C3] |
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2010 |
Balogh ZJ, 'Discussion', Journal of Trauma, 68 638-640 (2010) [C3]
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2010 |
Balogh ZJ, 'Editorial comment', Journal of Trauma - Injury, Infection and Critical Care, 68 638-640 (2010) [C3]
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2010 |
Enninghorst N, Toth L, King KL, McDougall D, Mackenzie S, Balogh ZJ, 'Acute definitive internal fixation of pelvic ring fractures in polytrauma patients: A feasible option', Journal of Trauma - Injury, Infection and Critical Care, 68 935-939 (2010) [C1]
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2010 |
Toth L, Balogh ZJ, 'Isolated unilateral sacroiliac dislocation without anterior pelvic ring disruption', Journal of Trauma-Injury Infection and Critical Care, 68 E83-E86 (2010) [C3]
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2010 |
Balogh ZJ, 'Skeletal traction versus external fixation in the initial temporization of femoral shaft fractures in severely injured patients. Editorial Comment', Journal of Trauma-Injury Infection and Critical Care, 68 639-640 (2010) [C3] |
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2010 |
Balogh ZJ, Butcher N, 'Compartment syndromes from head to toe', Critical Care Medicine, 38 S445-S451 (2010) [C1]
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2010 |
Balogh ZJ, Evans JA, 'Epidemiology of trauma deaths: Volume, methodology, and comparability-Reply to Letter', World Journal of Surgery, 34 1722-1723 (2010) [C3]
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2010 |
Balogh ZJ, Evans JA, 'Epidemiology of trauma deaths: Location, location, location! Reply', World Journal of Surgery, 34 1722-1723 (2010) [C3] |
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2010 |
Evans JA, Van Wessem KJP, McDougall D, Lee KA, Lyons TJ, Balogh ZJ, 'Epidemiology of traumatic deaths: Comprehensive population-based assessment', World Journal of Surgery, 34 158-163 (2010) [C1]
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2010 |
Williams-Johnson JA, McDonald AH, Strachan GG, Williams EW, 'Effects of Tranexamic Acid on Death, Vascular Occlusive Events, and Blood Transfusion in Trauma Patients with Significant Haemorrhage (CRASH-2) A Randomised, Placebo-Controlled Trial', WEST INDIAN MEDICAL JOURNAL, 59 612-624 (2010)
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2010 |
Coimbra R, Huynh TT, Billiar TR, Balogh Z, Poggetti RS, 'Discussion', Journal of Trauma - Injury, Infection and Critical Care, 69 366-367 (2010)
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2010 |
Balogh ZJ, 'Traumatology in Australia: Provision of clinical care and trauma system development', ANZ Journal of Surgery, 80 119-121 (2010) [C3]
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2009 |
De Waele JJ, Cheatham ML, Malbrain MLNG, Kirkpatrick AW, Sugrue M, Balogh ZJ, et al., 'Recommendations for research from the international conference of experts on intra-abdominal hypertension and abdominal compartment syndrome', Acta Clinica Belgica, 64 203-209 (2009) [C1]
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2009 |
Cheatham M, De Waele J, Kirkpatrick A, Sugrue M, Malbrain MLN, Ivatury RR, et al., 'Criteria for a diagnosis of abdominal compartment syndrome', Canadian Journal of Surgery, 52 315-316 (2009) [C3]
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2009 |
Dewar D, Moore FA, Moore EE, Balogh ZJ, 'Postinjury multiple organ failure', Injury, 40 912-918 (2009) [C1]
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2009 |
Tan SLE, Balogh ZJ, 'Indications and limitations of locked plating', Injury, 40 683-691 (2009) [C1]
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2009 |
Butcher N, Balogh ZJ, 'The definition of polytrauma: The need for international consensus', Injury - International Journal of the Care of the Injured, 40S4 S12-S22 (2009) [C1]
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2009 |
Sekine K, Holcomb JB, Moore FA, Duchesne J, Schreiber M, Hawkins ML, et al., 'Predefined Massive Transfusion Protocols are Associated With a Reduction in Organ Failure and Postinjury Complications DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 66 48-49 (2009) [C3]
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2009 |
Croce MA, Livingston DH, Duane TM, Asensio JA, McQuay N, Balogh ZJ, Dabbs DN, 'Major Hepatic Necrosis: A Common Complication After Angioembolization for Treatment of High-Grade Liver Injuries Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 66 627-629 (2009) [C3]
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2009 |
Sekine K, Holcomb JB, Moore FA, Duchesne J, Schreiber M, Hawkins ML, et al., 'Discussion', Journal of Trauma - Injury, Infection and Critical Care, 66 48-49 (2009) [C3]
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2009 |
Croce MA, Livingston DH, Duane TM, Asensio JA, McQuay N, Balogh ZJ, Dabbs DN, 'Discussion', Journal of Trauma - Injury, Infection and Critical Care, 66 627-629 (2009) [C3]
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2009 |
Balogh ZJ, Leppaniemi A, 'The neglected (abdominal) compartment: What is new at the beginning of the 21st century?', World Journal of Surgery, 33 1109 (2009) [C3]
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2009 |
Balogh ZJ, Van Wessem K, Yoshino O, Moore FA, 'Postinjury abdominal compartment syndrome: Are we winning the battle?', World Journal of Surgery, 33 1134-1141 (2009) [C1]
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2009 |
Dewar D, Mackay P, Balogh ZJ, 'Epidemiology of post-injury multiple organ failure in an Australian trauma system', ANZ Journal of Surgery, 79 431-436 (2009) [C1]
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2008 |
Lameire N, Balogh Z, Lumb P, 'Editorial introductions', Current Opinion in Critical Care, 14 (2008) [C3] |
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2008 |
Balogh ZJ, 'Section editor', Current Opinion in Critical Care, 14 (2008) [C2] |
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2008 |
Bendinelli C, Balogh ZJ, 'Postinjury thromboprophylaxis', Current Opinion in Critical Care, 14 673-678 (2008) [C1]
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2008 |
Sugrue M, Balogh ZJ, Lynch J, Bardsley J, Sisson G, Weigelt J, 'Guidelines for the management of haemodynamically stable patients with stab wounds [Letter]', ANZ Journal of Surgery, 78 106-107 (2008) [C3]
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2008 |
Sugrue M, Balogh ZJ, Lynch J, Bardsley J, Sisson G, Weigelt J, 'Re: Guidelines for the management of haemodynamically stable patients with stab wounds to the anterior abdomen [Letter]', ANZ Journal of Surgery, 78 111 (2008) [C3]
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2008 |
Balogh ZJ, 'Australian trauma care: Time for change', ANZ Journal of Surgery, 78 935-936 (2008) [C3]
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2008 |
Balogh ZJ, Bendinelli C, Pollitt T, Kozar RA, Moore FA, 'Postinjury primary abdominal compartment syndrome', European Journal of Trauma and Emergency Surgery, 34 369-377 (2008) [C1]
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2008 |
Cameron P, Phillips L, Balogh Z, Joseph A, Pearce A, Parr M, Jankelowitz G, 'The use of recombinant activated factor VII in trauma patients: Experience from the Australian and New Zealand haemostasis registry (vol 38, pg 1030, 2007)', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 39 138-139 (2008) [C3]
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2008 |
Collins JP, Civil ID, Sugrue M, Balogh ZJ, Chehade MJ, 'Surgical education and training in Australia and New Zealand', World Journal of Surgery, 32 2138-2144 (2008) [C1]
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2008 |
Verbeek D, Sugrue M, Balogh ZJ, Cass D, Civil I, Harris I, et al., 'Acute management of hemodynamically unstable pelvic trauma patients: Time for a change? Multicenter review of recent practice', World Journal of Surgery, 32 1874-1882 (2008) [C1]
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2007 |
Moore F, McKinley B, Balogh Z, 'The problem: Coagulopathy of posttraumatic massive transfusion (PMT)', INFLAMMATION RESEARCH, 56 S187-S188 (2007) |
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2007 |
Bodnar Z, Sipka S, Szentkereszty Z, Hajdu Z, Balogh Z, 'The gold standard technique for intra-abdominal pressure monitoring in septic patients: Continuous intra-abdominal pressure monitoring (CIAPM)', INFLAMMATION RESEARCH, 56 S213-S214 (2007)
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2007 |
Balogh Z, Bodnar Z, Moore F, 'Abdominal compartment syndrome complicating infection', INFLAMMATION RESEARCH, 56 S240-S240 (2007) |
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2007 |
Sugrue M, Balogh ZJ, Lynch J, Bardsley J, Sisson G, Weigelt J, 'Guidelines for the management of haemodynamically stable patients with stab wounds to the anterior abdomen', ANZ Journal of Surgery, 77 614-620 (2007) [C1]
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2007 |
Cheatham ML, Malbrain M, Kirkpatrick A, Sugrue M, Parr M, Dewaele J, et al., 'Results from the International Conference of Experts on Intra-Abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations', Intensive Care Medicine, 33 951-962 (2007) [C1]
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2007 |
Balogh Z, 'Continuous intra-abdominal pressure monitoring', ACTA CLINICA BELGICA, 62 234-234 (2007) |
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2007 |
Mackay P, van Wessem K, Balogh Z, 'Post-injury abdominal compartment syndrome: Is it still a problem?', ACTA CLINICA BELGICA, 62 293-293 (2007) |
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2007 |
Balogh ZJ, De Waele JJ, Malbrain M, 'Continuous intra-abdominal pressure monitoring', Acta Clinica Belgica, 62 26-32 (2007) [C1]
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2007 |
Cameron P, Phillips L, Balogh ZJ, Joseph A, Pearce A, Parr M, Jankelowitz G, 'The use of recombinant activated factor VII in trauma patients: Experience from the Australian and New Zealand haemostasis registry', Injury, 38 1030-1038 (2007) [C1]
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2007 |
Balogh ZJ, Moore FA, Moore EE, Biffl WL, 'Secondary abdominal compartment syndrome: A potential threat for all trauma clinicians', Injury - International Journal of the Care of the Injured, 38 272-279 (2007) [C1]
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2007 |
Peitzman AB, Balogh Z, Hauser C, 'The epidemiology of pelvic ring fractures: A population-based study - Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 63 1072-1073 (2007)
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2007 |
Balogh ZJ, Evans JA, Seah PW, King KL, 'Supraclavicular cyanosis: Clinical sign of acute blunt traumatic pericardial tamponade', Journal of Trauma - Injury, Infection and Critical Care, 63 245 (2007) [C3] |
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2007 |
Balogh Z, King KL, Mackay P, McDougall D, Mackenzie S, Evans JA, et al., 'The epidemiology of pelvic ring fractures: A population-based study', Journal of Trauma-Injury Infection and Critical Care, 63 1066-1073 (2007) [C1]
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2007 |
Balogh ZJ, De Waele JJ, Kirkpatrick A, Cheatham M, D'Amours S, Malbrain M, 'Intra-abdominal pressure measurement and abdominal compartment syndrome: The opinion of the World Society of the Abdominal Compartment Syndrome (Letter)', Critical Care Medicine, 35 677-678 (2007) [C3]
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2006 |
Malbrain MLNG, Cheatham ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, et al., 'Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions', Intensive Care Medicine, 32 1722-1732 (2006) [C1]
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2006 |
Balogh Z, Kirkpatrick AW, Ball CG, Zygun D, 'The secondary abdominal compartment syndrome: Iatrogenic or unavoidable?', JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 203 406-407 (2006)
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2006 |
Kirkpatrick AW, Balogh ZJ, Ball CG, Ahmed N, Chun R, McBeth P, et al., 'The secondary abdominal compartment syndrome: Iatrogenic or unavoidable?', Journal of the American College of Surgeons, 202 668-679 (2006) [C1]
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2006 |
Ollerton JE, Sugrue M, Balogh Z, D'Amours SK, Giles A, Wyllie P, 'Prospective study to evaluate the influence of FAST on trauma patient management', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 60 785-791 (2006)
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2005 |
Balogh Z, Moore FA, 'Intra-abdominal hypertension: Not just a surgical critical care curiosity', CRITICAL CARE MEDICINE, 33 447-449 (2005)
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2005 |
Balogh Z, Caldwell E, Heetveld M, D'Amours S, Schlaphoff G, Harris I, Sugrue M, 'Institutional practice guidelines on management of pelvic fracture-related hemodynamic instability: Do they make a difference?', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 58 778-782 (2005)
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2004 |
Cribari C, Balogh Z, Moore F, Kuhls D, 'Continuous intra-abdominal pressure measurement technique - Discussion', AMERICAN JOURNAL OF SURGERY, 188 683-684 (2004) |
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2004 |
Balogh Z, Moore FA, McKinley BA, 'Supranormal trauma resuscitation and abdominal compartment syndrome - In reply', ARCHIVES OF SURGERY, 139 226-227 (2004)
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2004 |
Heetveld MJ, Harris I, Schlaphoff G, Balogh Z, D'Amours SK, Sugrue M, 'Hemodynamically unstable pelvic fractures: Recent care and new guidelines', WORLD JOURNAL OF SURGERY, 28 904-909 (2004)
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2004 |
Balogh Z, Moore FA, 'Recent advances in the characterisation of post-injury abdominal compartment syndrome', International Journal of Intensive Care, 11 30-42 (2004)
Abdominal compartment syndrome (ACS) is defined as intra-abdominal pressure (IAP) higher than 25 mmHg with organ dysfunction (cardiac, respiratory, renal) if the organ dysfunction... [more]
Abdominal compartment syndrome (ACS) is defined as intra-abdominal pressure (IAP) higher than 25 mmHg with organ dysfunction (cardiac, respiratory, renal) if the organ dysfunction improves after abdominal decompression. ACS is the imbalance between abdominal volume and abdominal content where the abdominal volume is defined by the least tensile component of the abdominal compartment (i.e. the fascia). Increasing abdominal content or decreasing volume causes ACS, which impairs abdominal organ perfusion, as in other well recognised 'compartment' conditions of increased intra-cranial pressure, pericardial tamponade, tension pneumothorax or extremity compartment syndromes.
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2004 |
Sugrue M, Balogh Z, Malbrain M, 'Intra-abdominal hypertension and renal failure', ANZ JOURNAL OF SURGERY, 74 78-78 (2004)
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2004 |
Ivatury RR, Balogh Z, Moore FA, McKinley BA, 'Supranormal Trauma Resuscitation and Abdominal Compartment Syndrome [2] (multiple letters)', Archives of Surgery, 139 225-227 (2004)
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2003 |
Balogh ZJ, 'Supra-normal trauma resuscitation causes more cases of abdominal compartment syndrome', Archives of Surgery, 637-642 (2003) [C1]
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2003 |
Balogh Z, Voros E, Suveges G, Simonka JA, 'Stent graft treatment of an external iliac artery injury associated with pelvic fracture - A case report', JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 85A 919-922 (2003)
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2003 |
Reilly P, Balogh Z, Shackford SR, Wang D, 'Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure - Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 54 859-861 (2003)
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2003 |
Miller CC, Balogh Z, McKinley BA, Moore FA, 'Letter to the Editor - The Author's Reply', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 55 1004-1005 (2003) |
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2003 |
Miller CC, Balogh Z, McKinley BA, Moore FA, 'The Author s Reply', Journal of Trauma, 55 1004-1005 (2003)
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2003 |
Balogh ZJ, Varga E, Tomka J, Suveges G, Toth L, Simonka JA, 'The new injury severity score is a better predictor of extended hospitalization and intensive care unit admission than the injury severity score in patients with multiple orthopaedic injuries', JOURNAL OF ORTHOPAEDIC TRAUMA, 17 508-512 (2003)
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2003 |
Balogh Z, McKinley BA, Cox CS, Allen SJ, Cocanour CS, Kozar RA, et al., 'Abdominal compartment syndrome: The cause or effect of postinjury multiple organ failure', SHOCK, 20 483-492 (2003)
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2002 |
Balogh Z, Wolfard A, Szalay L, Orosz E, Simonka JA, Boros M, 'Dalteparin sodium treatment during resuscitation inhibits hemorrhagic shock-induced leukocyte rolling and adhesion in the mesenteric microcirculation', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 52 1062-1069 (2002)
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2002 |
Burch J, Balogh Z, Smith S, 'Secondary abdominal compartment syndrome is an elusive early complication of traumatic shock resuscitation - Discussion', AMERICAN JOURNAL OF SURGERY, 184 543-544 (2002)
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2000 |
Balogh Z, Offner PJ, Moore EE, Biffl WL, 'NISS predicts postinjury multiple organ failure better than the ISS', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 48 624-627 (2000)
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2000 |
Osler TM, West A, Hauser CJ, Lewis FR, Balogh Z, 'NISS predicts postinjury multiple organ failure better than the ISS - Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 48 627-628 (2000)
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1999 |
Wolfard A, Kaszaki J, Szabo C, Balogh Z, Nagy S, Boros M, 'Effects of selective nitric oxide synthase inhibition in hyperdynamic endotoxemia in dogs', EUROPEAN SURGICAL RESEARCH, 31 314-323 (1999)
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1997 |
Wolfárd A, Kaszaki J, Szabó C, Balogh Z, Nagy S, 'Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia.', Acta chirurgica Hungarica, 36 393-394 (1997)
In this study we compared the circulatory effects of the arginine analogue non-specific nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (NNA), and the specific indu... [more]
In this study we compared the circulatory effects of the arginine analogue non-specific nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (NNA), and the specific inducible NOS (iNOS) inhibitor S-methylisothiourea (SMT) and S-(2-aminoethyl)-isothiourea (AEST) in a hyperdynamic endotoxemic dog model. Mean arterial pressure (MAP), cardiac output (CO), and myocardial contractility (MC) were measured. A hyperdynamic circulatory response was elicited with a 2-h infusion of a total dose of 5.3 micrograms/kg E. coli endotoxin (ETX). NOS inhibitory treatment (2 mg/kg) was administrated from the 45th min of endotoxemia. ETX induced a hyperdynamic circulatory response, and a significant myocardial depression. NNA induced a prolonged, SMT a transient increase in MC, both drugs elevated MAP, but decreased CO. AEST significantly prolonged the elevation in CO, but did not affect MAP. Selective inhibition of the iNOS may be a beneficial in sepsis.
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