
Dr Alan Hsu
Post-Doctoral Research Fellow
School of Medicine and Public Health (Immunology and Microbiology)
- Email:alan.hsu@newcastle.edu.au
- Phone:(02) 4042 0109
Career Summary
Biography
Influenza viruses will always pose a significant threat to humanity. The emergence of novel and re-emergence of ancient viruses are becoming great concerns globally. Despite the availability of annual vaccination and antiviral drugs, viruses continue to rapidly mutate and become resistant to antiviral drugs and evade from vaccine-mediated humoral immunity.
Dr. Alan Hsu is primarily focused on the molecular mechanisms of human innate immune responses to influenza viruses, including high pathogenic avian influenza viruses, and chronic airways diseases such as asthma and chronic obstructive pulmonary disease (COPD). By understanding the mechanisms of influenza virus infections and their interactions with the host innate immune signaling proteins, this will not only identify novel virus-host and host protein-protein-RNA interactions, this will also identify novel therapeutic targets for influenza. People with asthma and COPD are highly susceptible to infection with influenza viruses and experience more severe symptoms with increased mortality. The mechanisms of this high susceptibility and severe infection outcome in asthma and COPD are unknown.
He discovered that influenza virus endocytosis requires a multitude of host signaling proteins including EGFR, PI3K, and SOCS5 on the plasma membrane and in the cytoplasm. Inhibition of PI3K and SOCS5 activities resulted in reduced influenza virus entry and viral replication, regardless of virus strains/subtypes. He also discovered for the first time that bronchial epithelial cells from those with COPD were highly susceptible to more efficient influenza viral entry, and showed enhanced inflammatory but impaired antiviral responses to infection. Highly pathogenic avian influenza H5N1 completely abolished human antiviral response whilst led to a hyper-inflammatory response (aka inflammatory cytokine storm). Dr. Alan Hsu also discovered several innate immune mechanisms that regulate the antiviral and inflammatory responses to influenza virus infections, and how these immune regulations are altered in those with asthma and COPD. These novel immune mechanisms provide a unique class of “host-targeted” immuno-therapeutic options that would be effective against multiple subtypes/strains of influenza viruses, or even other families of viruses such as coronaviruses. This work is of tremendous importance in the preparation for future emergence of influenza viruses and pandemics that have unpredictable consequences.
“ The single biggest threat to men’s continued dominance on the planet is the virus.”
- Joshua Lederberg, Nobel laureate 1958
Qualifications
- PhD (Medicine), University of Newcastle
Keywords
- Asthma
- COPD
- Immunology
- Influenza
- Influenza virus
- Molecular Biology
- Virology
Languages
- English (Fluent)
Fields of Research
Code | Description | Percentage |
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060506 | Virology | 35 |
110203 | Respiratory Diseases | 30 |
110707 | Innate Immunity | 35 |
Professional Experience
UON Appointment
Title | Organisation / Department |
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Post-Doctoral Research Fellow | University of Newcastle School of Medicine and Public Health Australia |
Academic appointment
Dates | Title | Organisation / Department |
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1/01/2013 - | Membership - International Society for Interferon and Cytokine Research | International Society for Interferon and Cytokine Research United States |
1/01/2007 - | Membership - The Thoracic Society of Australia & New Zealand | The Thoracic Society of Australia & New Zealand Australia |
1/01/2007 - | Membership - Australasian Society for Immunology | Australasian Society for Immunology Australia |
Awards
Recipient
Year | Award |
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2015 |
Federation of Immunological Societies Asia-Oceania (FIMSA) Travel fellowship Singaporean Society for Immunology |
2014 |
The Milstein Travel Awards International Cytokine and Interferon Society |
2012 |
TSANZ Travel Award Thoracic Society of Australia and New Zealand |
2009 |
TSANZ Travel Award Thoracic Society of Australia and New Zealand |
Recognition
Year | Award |
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2013 |
Priority Research Centre Early Career Research Development Award Priority Research Centre (PRC) for Healthy Lungs | The University of Newcastle |
Research Award
Year | Award |
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2016 |
TSANZ / AstraZeneca Respiratory Research Fellowship The University of Newcastle - Faculty of Health and Medicine |
2012 |
Winner - Ann Woolcock Young Investigator Award Thoracic Society of Australia and New Zealand |
Invitations
Keynote Speaker
Year | Title / Rationale |
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2017 |
Micro-RNAs in Innate immunity Invited seminar by A/Prof. Sandra Nicholson, WEHI, The Peter Doherty Institute for Infection and Immunity, and University of Melboune, Vic, Australia |
2016 |
The Elegance of Influenza & Human Immunity Invited seminar |
2016 |
The Age of Stress Invited seminar |
2016 |
Viral infections & Immunity: A Game of Homeostasis Invited seminar |
2016 |
COPD: Immune-dysregulations & Immuno-therapeutic potentials Invited seminar |
2015 |
Respiratory Viral Infections & Innate Immunity Special Seminar |
Grant Reviews
Year | Grant | Amount |
---|---|---|
2017 |
National Health & Medical Research Council Aust Competitive - Commonwealth - 1CS, Aust Competitive - Commonwealth - 1CS Project grant reviews |
$0 |
2017 |
Biotechnology and Biological Sciences Research Council (BBSRC) | United Kingdom International - Competitive - 3IFA, International - Competitive - 3IFA Keywords - Influenza virus ; avian influenza virus ; Influenza virus transmission ; Innate Immunity |
$0 |
2016 |
British Lung Foundation International - Competitive - 3IFA, International - Competitive - 3IFA |
$0 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (2 outputs)
Year | Citation | Altmetrics | Link | |||||
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2014 |
Hsu A, Zhong H, Hansbro P, Wark P, 'Innate Immunity in the Airways to Respiratory Viruses', Virology II - Advanced Issues, iConcept Press, Hong Kong 1-32 (2014) [B1]
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2014 |
Hsu A, Loo S, Fathi Aghdam F, Parsons K, Hansbro P, Wark P, 'Airway Epithelial and Early Innate Immune Responses to Virus Infections', Human Respiratory Viral Infections, CRC Press, Boca Raton, FL 29-44 (2014) [B1]
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Journal article (22 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2018 |
Hsu A, 'Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions', Frontiers in Immunology, 9 (2018)
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2018 |
Chellappan DK, Ng ZY, Wong J-Y, Hsu A, Wark P, Hansbro N, et al., 'Immunological axis of curcumin-loaded vesicular drug delivery systems.', Future Med Chem, (2018)
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2018 |
Tan DBA, Teo T-H, Setiawan AM, Ong NE, Zimmermann M, Hsu AC-Y, et al., 'Impaired Th1 responses in patients with acute exacerbations of COPD are improved with PD-1 blockade', CLINICAL IMMUNOLOGY, 188 64-66 (2018)
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2018 |
Pathinayake PS, Hsu AC-Y, Waters DW, Hansbro PM, Wood LG, Wark PAB, 'Understanding the Unfolded Protein Response in the Pathogenesis of Asthma', FRONTIERS IN IMMUNOLOGY, 9 (2018) [C1]
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2017 |
Conickx G, Mestdagh P, Cobos FA, Verhamme FM, Maes T, Vanaudenaerde BM, et al., 'MicroRNA profiling reveals a role for MicroRNA-218-5p in the pathogenesis of chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 195 43-56 (2017) [C1] Rationale: Aberrant expression of microRNAs (miRNAs) can have a detrimental role in disease pathogenesis. Objectives: To identify dysregulated miRNAs in lung tissue of patients wi... [more] Rationale: Aberrant expression of microRNAs (miRNAs) can have a detrimental role in disease pathogenesis. Objectives: To identify dysregulated miRNAs in lung tissue of patients with chronic obstructive pulmonary disease (COPD). Methods: We performed miRNA and mRNA profiling using high throughput stem-loop reverse-transcriptase quantitative polymerase chain reaction and mRNA microarray, respectively, on lung tissue of 30 patients (screening cohort) encompassing 8 never-smokers, 10 smokers without airflow limitation, and 12 smokers with COPD. Differential expression of miRNA-218-5p (miR-218-5p) was validated by reverse-transcriptase quantitative polymerase chain reaction in an independent cohort of 71 patients, an in vivo murine model of COPD, and primary human bronchial epithelial cells. Localization of miR-218-5p was assessed by in situ hybridization. In vitro and in vivo perturbation of miR-218-5p combined with RNA sequencing and gene set enrichment analysis was used to elucidate its functional role in COPD pathogenesis. Measurements and Main Results: Several miRNAs were differentially expressed among the different patient groups. Interestingly, miR-218-5p was significantly down-regulated in smokers without airflow limitation and in patients with COPD compared with never-smokers. Decreased pulmonary expression of miR-218-5p was validated in an independent validation cohort, in cigarette smoke-exposed mice, and in human bronchial epithelial cells. Importantly, expression of miR-218-5p strongly correlated with airway obstruction. Furthermore, cellular localization of miR-218-5p in human and murine lung revealed highest expression of miR-218-5p in the bronchial airway epithelium. Perturbation experiments with a miR-218-5p mimic or inhibitor demonstrated a protective role of miR-218-5p in cigarette smoke-induced inflammation and COPD. Conclusions: We highlight a role for miR-218-5p in the pathogenesis of COPD.
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2017 |
Huff RD, Hsu ACY, Nichol KS, Jones B, Knight DA, Wark PAB, et al., 'Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells', PLoS ONE, 12 1-17 (2017) [C1]
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2017 |
Liu G, Cooley MA, Nair PM, Donovan C, Hsu AC, Jarnicki AG, et al., 'Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c', JOURNAL OF PATHOLOGY, 243 510-523 (2017) [C1]
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2017 |
Kedzierski L, Tate MD, Hsu AC, Kolesnik TB, Linossi EM, Dagley L, et al., 'Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling', eLife, 6 1-27 (2017) [C1]
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2017 |
Hsu AC-Y, Dua K, Starkey MR, Haw T-J, Nair PM, Nichol K, et al., 'MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD', JCI INSIGHT, 2 (2017) [C1]
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2016 |
Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, et al., 'A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease', Mucosal Immunology, 9 859-872 (2016) [C1] Chronic obstructive pulmonary disease (COPD) is a life-Threatening inflammatory respiratory disorder, often induced by cigarette smoke (CS) exposure. The development of effective ... [more] Chronic obstructive pulmonary disease (COPD) is a life-Threatening inflammatory respiratory disorder, often induced by cigarette smoke (CS) exposure. The development of effective therapies is impaired by a lack of understanding of the underlining mechanisms. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine with inflammatory and apoptotic properties. We interrogated a mouse model of CS-induced experimental COPD and human tissues to identify a novel role for TRAIL in COPD pathogenesis. CS exposure of wild-Type mice increased TRAIL and its receptor messenger RNA (mRNA) expression and protein levels, as well as the number of TRAIL + CD11b + monocytes in the lung. TRAIL and its receptor mRNA were also increased in human COPD. CS-exposed TRAIL-deficient mice had decreased pulmonary inflammation, pro-inflammatory mediators, emphysema-like alveolar enlargement, and improved lung function. TRAIL-deficient mice also developed spontaneous small airway changes with increased epithelial cell thickness and collagen deposition, independent of CS exposure. Importantly, therapeutic neutralization of TRAIL, after the establishment of early-stage experimental COPD, reduced pulmonary inflammation, emphysema-like alveolar enlargement, and small airway changes. These data provide further evidence for TRAIL being a pivotal inflammatory factor in respiratory diseases, and the first preclinical evidence to suggest that therapeutic agents that target TRAIL may be effective in COPD therapy.
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2016 |
Hsu ACY, Parsons K, Moheimani F, Knight DA, Hansbro PM, Fujita T, Wark PA, 'Impaired antiviral stress granule and IFN-ß enhanceosome formation enhances susceptibility to influenza infection in chronic obstructive pulmonary disease epithelium', American Journal of Respiratory Cell and Molecular Biology, 55 117-127 (2016) [C1] Chronic obstructive pulmonary disease (COPD) is a serious lung disease that progressively worsens lung function. Those affected are highly susceptible to influenza virus infection... [more] Chronic obstructive pulmonary disease (COPD) is a serious lung disease that progressively worsens lung function. Those affected are highly susceptible to influenza virus infections that result in exacerbations with exaggerated symptoms with increased mortality. The mechanisms underpinning this increased susceptibility to infection in COPD are unclear. In this study, we show that primary bronchial epithelial cells (pBECs) from subjects with COPD have impaired induction of type I IFN (IFN-ß) and lead to heightened viral replication after influenza viral infection. COPD pBECs have reduced protein levels of protein kinase (PK) R and decreased formation of PKR-mediated an tiviral stress granules, which are critical in initiating type I IFNinductions. In addition, reduced protein expression of p300 resulted in decreased activation of IFN regulatory factor 3 and subsequent formation of IFN-ß enhanceosome in COPD pBECs. The decreased p300 induction was the result of enhanced levels of microRNA (miR)-132. Ectopic expression of PKR or miR-132 antagomiR alone failed to restore IFN-ß induction, whereas cotreatment increased antiviral stress granule formation, induction of p300, and IFN-ß in COPD pBECs. This study reveals that decreased induction of both PKR and p300 proteins contribute to impaired induction of IFN-ß in COPD pBECs upon influenza infection.
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2016 |
Gang L, Hsu A, Cooley MA, Jarnicki AG, Nair PM, Haw TJ, et al., 'Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases', Journal of Clinical Investigation Insight, 1 (2016) [C1]
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2016 |
Moheimani F, Hsu AC-Y, Reid AT, Williams T, Kicic A, Stick SM, et al., 'The genetic and epigenetic landscapes of the epithelium in asthma', RESPIRATORY RESEARCH, 17 (2016) [C1]
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2015 |
Pathinayake PS, Hsu A, wark PA, 'Innate Immunity and Immune Evasion by Enterovirus 71', Viruses, 7 (2015) [C1]
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2015 |
Hsu ACY, Starkey MR, Hanish I, Parsons K, Haw TJ, Howland LJ, et al., 'Targeting PI3K-p110a suppresses influenza virus infection in chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 191 1012-1023 (2015) [C1] Copyright © 2015 by the American Thoracic Society. Rationale: Chronic obstructive pulmonary disease (COPD) and influenza virus infections are major global health issues. Patients ... [more] Copyright © 2015 by the American Thoracic Society. Rationale: Chronic obstructive pulmonary disease (COPD) and influenza virus infections are major global health issues. Patients with COPD are more susceptible to infection, which exacerbates their condition and increases morbidity and mortality. The mechanisms of increased susceptibility remain poorly understood, and current preventions and treatments have substantial limitations. Objectives: To characterize the mechanisms of increased susceptibility to influenza virus infection in COPD and the potential for therapeutic targeting. Methods: We used a combination of primary bronchial epithelial cells (pBECs) from COPD and healthy control subjects, a mouse model of cigarette smoke-induced experimental COPD, and influenza infection. The role of the phosphoinositide-3-kinase (PI3K) pathway was characterized using molecular methods, and its potential for targeting assessed using inhibitors. Measurements and Main Results: COPDpBECs were susceptible to increased viral entry and replication. Infected mice with experimental COPD also had more severe infection (increased viral titer and pulmonary inflammation, and compromised lung function). These processes were associated with impaired antiviral immunity, reduced retinoic acid-inducible gene-I, and IFN/cytokine and chemokine responses. Increased PI3K-p110a levels and activity inCOPDpBECs and/or mice were responsible for increased infection and reduced antiviral responses. Global PI3K, specific therapeutic p110a inhibitors, or exogenous IFN-b restored protective antiviral responses, suppressed infection, and improved lung function. Conclusions: The increased susceptibility of individuals with COPD to influenza likely results from impaired antiviral responses, which are mediated by increased PI3K-p110a activity. This pathway may be targeted therapeutically in COPD, or in healthy individuals, during seasonal or pandemic outbreaks to prevent and/or treat influenza.
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2014 |
Parsons KS, Hsu AC, Wark PAB, 'TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection', Clinical and Experimental Allergy, 44 91-101 (2014) [C1] Summary: Background: Rhinoviruses (RV) are the most common acute triggers of asthma, and airway epithelial cells are the primary site of infection. Asthmatic bronchial epithelial ... [more] Summary: Background: Rhinoviruses (RV) are the most common acute triggers of asthma, and airway epithelial cells are the primary site of infection. Asthmatic bronchial epithelial cells (BECs) have been found to have impaired innate immune responses to RV. RV entry and replication is recognized by pathogen recognition receptors (PRRs), specifically toll-like receptor (TLR)3 and the RNA helicases; retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). Objective: Our aim was to assess the relative importance of these PRRs in primary bronchial epithelial cells (pBEC) from healthy controls and asthmatics following RV infection and determine whether deficient innate immune responses in asthmatic pBECs were due to abnormal signalling via these PRRs. Methods: The expression patterns and roles of TLR3 and MDA5 were investigated using siRNA knock-down, with subsequent RV1B infection in pBECs from each patient group. We also used BX795, a specific inhibitor of TBK1 and IKKi. Results: Asthmatic pBECs had significantly reduced release of IL-6, CXCL-8 and IFN-¿ in response to RV1B infection compared with healthy pBECs. In healthy pBECs, siMDA5, siTLR3 and BX795 all reduced release of IL-6, CXCL-10 and IFN-¿ to infection. In contrast, in asthmatic pBECs where responses were already reduced, there was no further reduction in IL-6 and IFN-¿, although there was in CXCL-10. Conclusion and Clinical Relevance: Impaired antiviral responses in asthmatic pBECs are not due to deficient expression of PRRs; MDA5 and TLR3, but an inability to later activate types I and III interferon immune responses to RV infection, potentially increasing susceptibility to the effects of RV infection. © 2013 John Wiley & Sons Ltd.
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2013 |
Baines KJ, Hsu AC-Y, Tooze M, Gunawardhana LP, Gibson PG, Wark PAB, 'Novel immune genes associated with excessive inflammatory and antiviral responses to rhinovirus in COPD', RESPIRATORY RESEARCH, 14 (2013) [C1]
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2012 |
Hsu A, See HV, Hansbro PM, Wark PA, 'Innate immunity to influenza in chronic airways diseases', Respirology, 17 1166-1175 (2012) [C1]
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2012 |
Hsu A, Parsons KS, Barr I, Lowther S, Middleton D, Hansbro PM, Wark PA, 'Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection', PLoS One, 7 (2012) [C1]
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2011 |
Hsu A, Barr I, Hansbro PM, Wark PA, 'Human influenza is more effective than Avian influenza at antiviral suppression in airway cells', American Journal of Respiratory Cell and Molecular Biology, 44 906-913 (2011) [C1]
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Show 19 more journal articles |
Review (1 outputs)
Year | Citation | Altmetrics | Link | ||
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2018 |
Hsu A, 'Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions', Frontiers in Immunology (2018)
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Conference (30 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2018 |
Hsu A, Hansbro P, Wark P, 'HDAC6 PROMOTES DDX1-MEDIATED ANTIVIRAL IMMUNITY AND IS IMPAIRED IN COPD', RESPIROLOGY (2018)
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2018 |
Loo S, Nichol K, Hsu A, Londrigan S, Reading P, Bartlett N, Wark P, 'AIRWAY EPITHELIAL INNATE IMMUNE RESPONSES TO CORONAVIRUSES', RESPIROLOGY (2018)
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2018 |
Pathinayake P, Nichol K, Baines K, Wood L, Hsu A, Wark P, 'THE UNFOLDED PROTEIN RESPONSE VARIES BETWEEN INFLAMMATORY PHENOTYPES OF ASTHMA', RESPIROLOGY (2018)
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2015 |
Hsu A, Parsons K, Hansbro P, Wark P, 'ENHANCED PI3K ACTIVITY LEADS TO DECREASED INTERFERON-beta RESPONSE TO INFLUENZA INFECTION IN COPD', RESPIROLOGY, Queensland, AUSTRALIA (2015) [E3]
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2015 |
Loo S, Hsu A, Hansbro P, Wark P, 'THE ROLE OF PI3 KINASE IN INFLUENZA H1N1 AND RHINOVIRUS VIRAL ENTRY INTO PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY, Queensland, AUSTRALIA (2015) [E3]
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2014 |
Hsu A, Parsons K, Fujita T, Hansbro P, Wark P, 'Critical role of PKR in antiviral stress granule and IFN-beta enhanceosome formation, and is impaired in chronic obstructive pulmonary disease', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
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2014 |
Hsu A, Parsons K, Hansbro P, Wark P, 'Enhanced PI3K activity leads to decreased IFN-beta response to influenza infection in chronic obstructive pulmonary disease', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
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2014 |
Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
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2014 |
Fathi F, Hsu A, Parsons K, Keely S, Wood L, Wark P, 'OXIDATIVE STRESS IMPAIRS MITOCHONDRIAL FUNCTION AND LEADS TO DEFICIENT ANTIVIRAL RESPONSES IN PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY (2014) [E3]
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2014 |
Hsu A, Parsons K, Hansbro P, Wark P, Wark P, 'IMPAIRED FORMATION OF ANTIVIRAL STRESS GRANULE AND INTERFERON-BETA ENHANCEOSOME LEADS TO REDUCED ANTIVIRAL RESPONSES TO INFLUENZA IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY (2014) [E3]
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2014 |
Starkey MR, Hanish I, Dua K, Hsu A, Monogar P, Foster PS, et al., 'Interleukin-13 Predisposes Mice To More Severe Influenza Infection And Exacerbated Allergic Airways Disease', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)
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2013 |
Baines KJ, Simpson JL, Mcdonald VM, Hsu AC, Gibson PG, 'DIFFERENTIAL AIRWAY GENE EXPRESSION IN COPD', RESPIROLOGY (2013) [E3]
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2012 |
Hsu A, Parsons KS, Barr I, Hansbro PM, Wark PA, 'Deficient antiviral responses to influenza in primary bronchial epithelial cells of chronic obstructive pulmonary disease', Respirology, Canberra, ACT (2012) [E3]
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2012 |
Wark PA, Tooze MK, Hsu A, Parsons KS, 'Silencing of MDA5 and TLR3 does not reduce innate immune responses to rhinovirus in defective asthmatic bronchial epithelial cells', Respirology, Canberra, ACT (2012) [E3]
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2011 |
Parsons KS, Tooze MK, Hsu A, Wark PA, 'Oxidative stress induces mitochondrial dusfunction in airway epithelial cells and impairs response to rhinovirus', Respirology, Perth, WA (2011) [E3]
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2011 |
Wark PA, Parsons KS, Tooze MK, Hsu A, 'MDA5 is crucial inhibiting rhinovirus replication in primary bronchial epithelial cells', Respirology, Perth, WA (2011) [E3]
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2009 |
Wark PA, Hsu A, Hansbro PM, 'Innate immune response of bronchial epithelial cells to infection with influenza', Journal of Immunology, Seattle, WASH. (2009) [E3]
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2009 |
Hsu A, Hansbro PM, Barr I, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', Respirology, Darwin, NT (2009) [E3]
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2008 |
Hsu A, Grissell TV, Wark PA, 'Distribution of SAa2,6GAL and SAa2,3GAL linked receptors in human respiratory tract and influenza virus replication', Respirology, Melbourne, VIC (2008) [E3]
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2008 |
Hsu A, Hansbro PM, Wark PA, 'Innate immune response of bronchial epithelial cells to human and avian influenza virus', The 4th Congress of the Federation of Immunology Societies of Asia-Oceania: Conference Program, Taipei, Taiwan (2008) [E3]
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Show 27 more conferences |
Grants and Funding
Summary
Number of grants | 12 |
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Total funding | $357,854 |
Click on a grant title below to expand the full details for that specific grant.
20172 grants / $22,500
Mechanisms of heightened airway inflammation in asthma and chronic obstructive pulmonary disease$20,000
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
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Project Team | Doctor Alan Hsu, Mr Prabuddha Pathinayake, Conjoint Professor Peter Wark |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | G1700465 |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | Y |
Inhibition of microRNA-200 subfamily restores HDAC6-deficiency-mediated abnormal innate immunity to influenza in chronic obstructive pulmonary disease$2,500
Funding body: Faculty of Health and Medicine Pilot Grant University of Newcastle
Funding body | Faculty of Health and Medicine Pilot Grant University of Newcastle |
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Project Team | Alan Hsu |
Scheme | UON Faculty of Health and Medicine Pilot Grant |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20161 grants / $150,000
Enhancing stress granule formation and antiviral immunity to resolve high oxidative stress-inflammation in Chronic Obstructive Pulmonary Disease $150,000
Funding body: Thoracic Society of Australia and New Zealand
Funding body | Thoracic Society of Australia and New Zealand |
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Project Team | Doctor Alan Hsu |
Scheme | TSANZ/AstraZeneca - Respiratory Research Fellowship |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | G1600731 |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | Y |
20151 grants / $25,222
Enhanced oxidative stress impairs mitochondrial function and antiviral responses to rhinovirus infection in asthma and chronic obstructive pulmonary disease$25,222
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Doctor Alan Hsu, Conjoint Professor Peter Wark, Miss Kristy Nichol |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2015 |
GNo | G1500012 |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | Y |
20141 grants / $27,512
Mechanisms of dysregulated antiviral signallings to influenza infection in chronic obstructive pulmonary disease$27,512
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Doctor Alan Hsu, Doctor Fatemeh Moheimani, Professor Darryl Knight, Conjoint Professor Peter Wark |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1400435 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
20136 grants / $112,620
BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1201180 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Mechanisms of impaired antiviral interferon response to influenza infection in primary bronchial epithelial cells from chronic obstructive pulmonary disease$23,810
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Doctor Alan Hsu, Conjoint Professor Peter Wark |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1300711 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
Mechanisms of impaired antiviral interferon response to influenza infection in primary bronchial epithelial cells from chronic obstructive pulmonary disease$23,810
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Alan Hsu |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2014 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Associate Professor Jay Horvat, Associate Professor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1201186 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Mechanisms of increased respiratory viral entry into primary bronchial epithelial cells from people with chronic obstructive pulmonary disease$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Alan Hsu |
Scheme | Early Career Researcher Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1300661 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Role of the transcriptional co-activator p300 in resetting epithelial differentiation: A potential pathway involved in asthma prevention and therapy$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Fatemeh Moheimani, Professor Darryl Knight, Ms Kirsty Wark, Doctor Alan Hsu, Doctor Malcolm Starkey |
Scheme | Early Career Researcher Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1301174 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20121 grants / $20,000
Molecular mechanism of high susceptibility to influenza infection in people with chronic obstructive pulmonary disease$20,000
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Alan Hsu |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2013 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
Research Supervision
Number of supervisions
Total current UON EFTSL
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2016 | PhD | Mechanisms and Therapeutic Targeting of Oxidative Stress in Lung Disease | PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
2015 | PhD | Functional roles of unfolded protein response and mitochondrial dysfunction in innate immunity in airway epithelium. | PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
2013 | PhD | Innate Anti-Viral Responses of Airway Epithelial Cells to Infection with Rhinovirus and Coronavirus | PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
Research Collaborations
The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.
Country | Count of Publications | |
---|---|---|
Australia | 45 | |
Canada | 8 | |
United States | 6 | |
United Kingdom | 4 | |
Malaysia | 4 | |
More... |
Dr Alan Hsu
Position
Post-Doctoral Research Fellow
Centre for Asthma and Respiratory Diseases
School of Medicine and Public Health
Faculty of Health and Medicine
Focus area
Immunology and Microbiology
Contact Details
alan.hsu@newcastle.edu.au | |
Phone | (02) 4042 0109 |
Fax | (02) 4042 0022 |
Link |
Office
Room | RM 2109 |
---|---|
Building | Level 2 West, Hunter Medical Research Institute (HMRI) |
Location | Lot 1, Kookaburra Circuit, New Lambton Height, NSW 2305. , |