Dr Kelly Asquith

Research Scientist

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Career Summary

Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Science (Biotechnology), University of Newcastle
  • Bachelor of Science (Honours)(Biotechnology), University of Newcastle

Keywords

  • Asthma
  • Allergy
  • Immunology
  • Biochemistry
  • Respiratory Infection

Fields of Research

Code Description Percentage
060199 Biochemistry and Cell Biology not elsewhere classified 15
110799 Immunology not elsewhere classified 70
060699 Physiology not elsewhere classified 15

Professional Experience

UON Appointment

Title Organisation / Department
Research Scientist University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/07/2008 - 1/09/2012 Fellow - NHMRC University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
15/01/2005 - 1/07/2008 Postdoctoral Researcher

Postdoctoral research position supported by an ARC Project Grant.

The University of Newcastle - School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (11 outputs)

Year Citation Altmetrics Link
2015 Siggs OM, Miosge LA, Daley SR, Asquith K, Foster PS, Liston A, Goodnow CC, 'Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation', Journal of Immunology, 194 2587-2595 (2015) [C1]

Copyright © 2015 by The American Association of Immunologists, Inc. Gene variants that disrupt TCR signaling can cause severe immune deficiency, yet less disruptive variants are s... [more]

Copyright © 2015 by The American Association of Immunologists, Inc. Gene variants that disrupt TCR signaling can cause severe immune deficiency, yet less disruptive variants are sometimes associated with immune pathology. Null mutations of the gene encoding the scaffold protein Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76), for example, cause an arrest of T cell positive selection, whereas a synthetic membrane-targeted allele allows limited positive selection but is associated with proinflammatory cytokine production and autoantibodies. Whether these and other enigmatic outcomes are due to a biochemical uncoupling of tolerogenic signaling, or simply a quantitative reduction of protein activity, remains to be determined. In this study we describe a splice variant of Lcp2 that reduced the amount of wild-type SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees. Mutant mice produced excessive amounts of proinflammatory cytokines, autoantibodies, and IgE, revealing that simple quantitative reductions of SLP-76 were sufficient to trigger immune dysregulation. This allele reveals a dose-sensitive threshold for SLP-76 in the balance of immunity and immune dysregulation, a common disturbance of atypical clinical immune deficiencies.

DOI 10.4049/jimmunol.1400326
Citations Scopus - 4Web of Science - 4
Co-authors Paul Foster
2012 Dun MD, Anderson AL, Bromfield EG, Asquith KL, Emmett BJ, McLaughlin EA, et al., 'Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)', International Journal of Andrology, 35 572-589 (2012) [C1]
DOI 10.1111/j.1365-2605.2011.01235.x
Citations Scopus - 15Web of Science - 12
Co-authors Elizabeth Bromfield, Matt Dun, John Aitken, Eileen Mclaughlin, Brett Nixon
2011 Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 (2011) [C1]
DOI 10.1371/journal.ppat.1001339
Citations Scopus - 37Web of Science - 36
Co-authors Paul Foster, Philip Hansbro, Gerard Kaiko, Jay Horvat
2010 Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Domachowske JB, Asquith KL, et al., 'Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice', Respiratory Research, 11 1-15 (2010) [C1]
DOI 10.1186/1465-9921-11-14
Citations Scopus - 54Web of Science - 52
Co-authors Paul Foster, Nicole Hansbro
2008 Foster PS, Rosenberg HF, Asquith KL, Kumar RK, 'Targeting eosinophils in asthma', Current Molecular Medicine, 8 585-590 (2008) [C1]
DOI 10.2174/156652408785748013
Citations Scopus - 21Web of Science - 19
Co-authors Paul Foster
2008 Asquith KL, Ramshaw HS, Hansbro PM, Beagley KW, Lopez AF, Foster PS, 'The IL-3/IL-5/GM-CSF common beta receptor plays a pivotal role in the regulation of Th2 immunity and allergic airway inflammation', Journal of Immunology, 180 1199-1206 (2008) [C1]
Citations Scopus - 73Web of Science - 71
Co-authors Paul Foster, Philip Hansbro
2006 Asquith KL, Kitchener AL, Kay DJ, 'Immunisation of the male tammar wallaby (Macropus eugenii) with spermatozoa elicits epididymal antigen-specific antibody secretion and compromised fertilisation rate', Journal of Reproductive Immunology, 69 127-147 (2006) [C1]
DOI 10.1016/j.jri.2005.08.004
Citations Scopus - 10Web of Science - 7
2005 Nixon B, Asquith KL, Aitken RJ, 'The role of molecular chaperones in mouse sperm-egg interactions', Molecular and Cellular Endocrinology, 240 1-10 (2005) [C1]
DOI 10.1016/j.mce.2005.06.004
Citations Scopus - 24Web of Science - 19
Co-authors Brett Nixon, John Aitken
2005 Asquith KL, Bielanowicz AJ, McLaughlin EA, Nixon B, Aitken RJ, 'Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction', Biology of Reproduction, 72 328-337 (2005) [C1]
DOI 10.1095/biolreprod.104.034470
Citations Scopus - 74Web of Science - 63
Co-authors Brett Nixon, Eileen Mclaughlin, John Aitken
2004 Ecroyd HW, Asquith KL, Jones RC, Aitken RJ, 'The development of signal transduction pathways during epididymal maturation is calcium dependent', Developmental Biology, 268 53-63 (2004) [C1]
DOI 10.1016/j.ydbio.2003.12.015
Citations Scopus - 35Web of Science - 33
Co-authors John Aitken
2004 Asquith KL, Baleato R, McLaughlin EA, Nixon B, Aitken RJ, 'Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition', Journal of Cell Science, 117 3645-3657 (2004) [C1]
DOI 10.1242/jcs.01214
Citations Scopus - 129Web of Science - 118
Co-authors Eileen Mclaughlin, Brett Nixon, John Aitken
Show 8 more journal articles

Conference (10 outputs)

Year Citation Altmetrics Link
2009 Siegle JS, Hansbro NG, Herbert C, Rosenberg HF, Asquith KL, Foster PS, Kumar RK, 'Interaction between early-life viral infection and allergen exposure induces an asthmatic phenotype in mice', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01502_7.x
Co-authors Paul Foster, Nicole Hansbro
2008 Asquith KL, Ramshaw H, Lopez A, Foster PS, 'The IL-3/IL-5/GM-CSF Common beta Receptor Plays a Pivotal Role in Regulating Th2 Immunity and Allergic Airway Inflammation', FASEB JOURNAL (2008) [E3]
Co-authors Philip Hansbro, Paul Foster
2006 Asquith K, 'Mutation of the adaptor protein SLP-76 inihibits allergic airway inflammation', Auckland,New Zealand (2006) [E4]
2004 Nixon B, Bielanowicz AJ, Asquith KL, Aitken RJ, 'The Molecular Basis of Epididymal Sperm Maturation', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authors Brett Nixon, John Aitken
2004 Walsh AK, Asquith KL, Thomas CM, Mitchell LA, Nixon B, Aitken RJ, 'Identification of Potential Zona Pellucida-binding Sperm Proteins using Heat Shock Protein 60', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authors John Aitken, Brett Nixon
2004 Asquith KL, Nixon B, McLaughlin EA, Aitken RJ, 'Tyrosine phosphorylation of mouse sperm proteins in a prerequisite for Zona Pellucida binding: potential involvement of molecular chaperones', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3]
Citations Web of Science - 1
Co-authors John Aitken, Brett Nixon, Eileen Mclaughlin
2003 Asquith KL, Nixon B, Aitken RJ, 'Surface Localisation of Chaperone Proteins in Spermatozoa', 28th Annual Lorne Conference on Protein Structure & Function, Lorne, Victoria (2003) [E3]
Co-authors Brett Nixon, John Aitken
2003 Asquith KL, McLaughlin EA, Nixon B, Aitken RJ, 'Localisation of Tyrosine Phosphorylated Proteins on Mouse Spermatozoa during Zona Pellucida Interaction and Characterisation of Sperm Surface Phosphoproteins', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3]
Co-authors Eileen Mclaughlin, Brett Nixon, John Aitken
2002 Asquith KL, Ecroyd HW, Aitken RJ, 'Tyrosine phosphorylation and epididymal maturation in murine spermatozoa', Proceedings of the Thirty-third Annual Conference of the Society for Reproductive Biology, Adelaide, SA (2002) [E3]
Co-authors John Aitken
2002 Asquith KL, Ecroyd HW, Aitken RJ, 'Tyrosine phosphorylatoin and epididymal maturation in murine spermatozoa', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
Co-authors John Aitken
Show 7 more conferences
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Grants and Funding

Summary

Number of grants 8
Total funding $515,607

Click on a grant title below to expand the full details for that specific grant.


20121 grants / $50,000

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Associate Professor Jay Horvat, Associate Professor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100975
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20111 grants / $45,000

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Associate Professor Simon Keely, Associate Professor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Laureate Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100037
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20101 grants / $39,000

Buxco FinePointe software and FinePointe RC system for mice $39,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000053
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20091 grants / $41,150

Coulter counter$41,150

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189851
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20084 grants / $340,457

Therapeutic potential of the IL-3/IL-5/GM-CSF common beta receptor to treat upper and lower allergic airway inflammation$279,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Kelly Asquith
Scheme Early Career Fellowships
Role Lead
Funding Start 2008
Funding Finish 2011
GNo G0188056
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188541
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Therapeutic potential of targeting the IL-3/IL-5/GM-CSF common beta receptor to treat allergic inflammation and asthma$23,957

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Kelly Asquith, Laureate Professor Paul Foster
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188460
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Experimental Biology 2008, San Diego, USA, 5/4/2008 - 9/4/2008$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Kelly Asquith
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188582
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed1
Current0

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2011 PhD Regulation of Mast Cell Degranulation by Protein Phosphatase 2A PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
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Dr Kelly Asquith

Position

Research Scientist
VIVA
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Email kelly.asquith@newcastle.edu.au
Phone (02) 40420182
Links Research Networks
Research Networks
Research Networks

Office

Room HMRI Level 2 East
Building HMRI
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