Dr Hayley Scott

Dr Hayley Scott

Post Doctoral Research Fellow

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Doctor Hayley Scott is a TSANZ/Astra-Zeneca Mid-Career Research Fellow and a senior member of the Nutrition Research Group at the Centre for Healthy Lungs, The University of Newcastle. She graduated with a Bachelor of Nutrition and Dietetics (Honours) in 2006 and is now an Accredited Practising Dietitian. Dr Scott completed her PhD in 2012, at The University of Newcastle. Her PhD studied the associations between obesity, fatty acids, airway and systemic inflammation and asthma, and investigated the effects of diet-induced weight loss and increased physical activity on these outcomes. Since the completion of her PhD, Dr Scott has continued her research in the areas of nutrition, exercise and obesity, and has expanded her research program to also include investigation of sex hormones and metabolic dysregulation. From 2014-2016, Dr Scott completed a Postdoctoral Fellowship at The University of Queensland, exploring whether exercising at different intensities produces a different inflammatory response in the airways of adults with asthma. Dr Scott is now completing her third Postdoctoral Fellowship, investigating the impact of sex hormones and obesity on immunometabolism and clinical asthma outcomes in women with asthma. Dr Scott’s qualification as a dietitian positions her uniquely within her field, as she has a thorough knowledge of nutrition and biochemical aspects of health and disease, and is able to perform specialised dietary manipulations to achieve specific changes in inflammation and clinical outcomes.

Dr Scott has published 30 manuscripts in international peer reviewed journals including European Respiratory Journal (IF=16.7), Progress in Lipid Research (IF=16.2), Allergy (IF=13.1) and American Journal of Clinical Nutrition (IF=6.4). She has also produced 49 conference abstracts and one book chapter. Dr Scott developed the first obesity management guidelines for adults with severe asthma, used by clinicians globally (Severe Asthma Toolkit, 2018, available here). She was also invited to contribute to “Better Living with COPD: A Patient Guide”, providing expertise regarding obesity in people with COPD (Lung Foundation Australia, 2015). The excellence of Dr Scott’s work has been recognised by >10 awards and prizes including a University of Newcastle Women in Research Fellowship (2017), the Outstanding Scholar Award from the Priority Research Centre for Healthy Lungs at The University of Newcastle (2018) and the Nutrition Society of Australia Emerging Researcher of the Year Award (2011). She was also invited to present her work at the Asian Pacific Society of Respirology International Conference in 2017 and a webinar for the NHMRC CRE in Severe Asthma in 2018, available online here.

Increasing interest in nutrition and lung health led Dr Scott to propose a Nutrition Special Interest Group (SIG) within the Thoracic Society of Australia and New Zealand (TSANZ), which she developed and Chaired from 2018-2019. From 2012-2014, Dr Scott Chaired the Newcastle Branch of the Nutrition Society of Australia (NSA) and was a National NSA Committee Member. She was the NSA Newcastle Branch Secretary from 2009-2011. Dr Scott is a Review Editor for Frontiers in Immunology and was the lead Guest Editor of a special issue on “Nutrition in Chronic Inflammatory Disease” for the Journal of Nutrition and Intermediary Metabolism (2019).

Research Expertise

Dr Scott's research examines the impact of nutrition, obesity, exercise and sex hormones on inflammation, and the effect this has on the pathogenesis of respiratory disease. The importance of these factors in lung health is now well recognised, but until recently there was a fundamental lack of good quality research in the field. Her research addresses this gap, demonstrating that improved weight status, modulation of dietary intake and increasing physical activity each independently reduces inflammation in the lungs and improves respiratory disease outcomes. The goal of Dr Scott’s research program is to provide mechanistic data that establishes how exactly these factors influence respiratory disease, to provide strong evidence for their inclusion in management guidelines. Her work has already contributed to the development of management guidelines and patient education materials, both internationally and nationally including the Global Strategy for Asthma Management and Prevention (GINA, 2021), the National Asthma Council Australian Asthma Handbook (2020) and Consumer Brochure Series (2013), the Severe Asthma Toolkit (NHMRC Centre of Research Excellence in Severe Asthma, 2018) and the British Guidelines for the Management of Asthma (2019).

Significant Discoveries to Date

Obesity: Dr Scott was the first internationally to demonstrate an association between obesity and airway inflammation in adults with asthma. She also proposed a new obese-asthma phenotype associated with obesity in women with late-onset asthma and elevated sputum neutrophils (named the "Neutrophilic Obese-Asthma Phenotype"). Dr Scott developed and tested a highly successful weight loss program for people with asthma, finding a 5-10% weight loss results in clinically important improvements in asthma symptoms and asthma-related quality of life in the majority of patients. This weight loss recommendation has since been translated into clinical practice guidelines published by the National Asthma Council and has been cited in international asthma management guidelines. Dr Scott also developed and implemented the dietetic components of the first weight loss intervention for obese adults with chronic obstructive pulmonary disease (COPD) which, coupled with resistance training, resulted in a 10% weight loss, maintenance of muscle mass and improvement in outcomes associated with mortality.

Diet: Dr Scott’s work demonstrates that higher levels of plasma saturated fatty acids are associated with a greater degree of airway inflammation in men with asthma, while reducing dietary intake of saturated fat is associated with a reduction in airway inflammation. In addition, saturated fat intake and obesity both independently cause NLRP3 inflammasome-mediated airway inflammation in adults with asthma. Taken together, her work suggests that both weight loss and dietary fat modulation are therapeutic targets for people with asthma, as each causes an increased inflammatory response. The team has also shown that increased erythrocyte omega-3 fatty acid levels are associated with better controlled asthma. The team has also shown that increasing antioxidant intake, by increasing the intake of fruits and vegetables, halves the risk of experiencing an asthma exacerbation and improves lung function, highlighting the large effect a single dietary modification can have on asthma outcomes.

Exercise: Dr Scott has demonstrated that exercise improves asthma, with 10 weeks of exercise training resulting in a halving of airway inflammation and an improvement in asthma-related quality of life. This training also resulted in significant increases in the anti-inflammatory gene, IL10, and the antioxidant gene, SOD2, in the airways. Dr Scott has also demonstrated an acute increase in plasma IL-1ra following a single bout of exercise, which strongly correlated with a reduction in airway inflammation. These novel findings suggest that the anti-inflammatory and antioxidant changes known to occur in response to exercise in the bloodstream of non-asthmatics are extending to the airways of those with asthma. Dr Scott recently led the first two studies internationally to examine the impact of exercise intensity on inflammation and asthma outcomes in adults, with the findings to be published in 2021.

Sex Hormones: Dr Scott was the first internationally to demonstrate that women with asthma using the oral contraceptive pill (OCP) have fewer asthma symptoms and less neutrophilic airway inflammation than those not using the OCP. The women not using the OCP had an increased expression of GLUT1 in their sputum, which is a key immunometabolic factor associated with increased inflammation. Dr Scott is now commencing a clinical study to establish the effect of sex hormones and the OCP on clinical outcomes and immunometabolism in women with severe and non-severe asthma. She will also determine whether obesity modifies these effects.

Teaching Expertise

Dr Scott’s teaching focuses on the nutritional and biochemical aspects of human health and disease. She has lectured undergraduate students in HUBS2207 (Human Metabolism and Nutritional Biochemistry), FSHN3020 (Nutrition in Health and Disease), FSHN3060 (Nutrition for the Life Cycle) and PHAR6704 (Pharmacology of Chronic Conditions). She has also managed computer labs for FSHN1020 (Introduction to Nutrition Science and Applications). Examples of her teaching areas include obesity and metabolic syndrome, cholesterol and lipid metabolism, cardiovascular disease, insulin secretion and signalling, biochemical aspects of diabetes, metabolism of omega-3 and omega-6 fatty acids, gastrointestinal disorders, food allergies and intolerances, antioxidants and oxidative stress, osteoporosis, and food allergies and intolerances.

Dr Scott is currently co-supervising one PhD student and has supervised 8 Honours students to completion (4x Nutrition & Dietetics, 2x Biomedical Sciences, 1x Food Science & Human Nutrition, 1x Exercise Physiology).


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Nutrition and Dietetics (Honours), University of Newcastle

Keywords

  • Asthma
  • Clinical trials
  • Fatty acids
  • Human Metabolism
  • Inflammation
  • Nutrition
  • Nutritional Biochemistry
  • Obesity
  • Respiratory Disease
  • Sex Hormones

Fields of Research

Code Description Percentage
321001 Clinical nutrition 34
320103 Respiratory diseases 33
320599 Medical biochemistry and metabolomics not elsewhere classified 33

Professional Experience

UON Appointment

Title Organisation / Department
Postdoctoral Research Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
Casual Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
3/8/2020 -  Casual Lecturer in Nutritional Biochemistry School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Australia
16/10/2019 -  TSANZ/Astra-Zeneca Mid-Career Research Fellow School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Australia
4/2/2019 - 15/11/2019 Lecturer in Human Nutrition School of Environmental and Life Sciences, University of Newcastle
Australia
2/4/2018 - 1/4/2019 TSANZ/National Asthma Council Australia Asthma and Airways Postdoctoral Research Fellow School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Australia
3/4/2017 -  Postdoctoral Research Fellow School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Australia
1/7/2014 - 30/6/2016 TSANZ/Astra-Zeneca Postdoctoral Research Fellow The University of Queensland
Australia
20/2/2012 - 30/6/2014 Postdoctoral Research Associate School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Australia
8/8/2011 - 10/3/2012 Research Assistant PRC in Physical Activity and Nutrition, University of Newcastle
Australia
1/2/2008 - 20/2/2012 CCRE in Respiratory and Sleep Medicine PhD Scholar School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle
Australia

Professional appointment

Dates Title Organisation / Department
1/2/2007 - 30/11/2007 Research Assistant in Nutrition and Dietetics

Nutrition and Dietetics

School of Health Sciences, Faculty of Health and Medicine, University of Newcastle
Australia

Teaching

Code Course Role Duration
FSHN1020 Food and Nutrients II
School of Environmental & Life Sciences - Faculty of Science & IT - The University of Newcastle | Australia
Computer Lab Manager 4/2/2019 - 30/6/2019
FSHN3020 Nutrition in Health and Disease
School of Environmental and Life Sciences, University of Newcastle
Lecturer in Human Nutrition 4/2/2019 - 30/6/2019
HUBS2207 Human Metabolism and Nutritional Biochemistry
School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Casual Lecturer in Nutritional Biochemistry 3/8/2020 - 31/12/2021
PHAR6704 Pharmacology of Chronic Conditions
School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle
Casual Lecturer 1/2/2021 - 30/6/2021
FSHN3060 Nutrition for the life cycle
School of Environmental and Life Sciences, University of Newcastle
Lecturer in Human Nutrition 1/7/2019 - 15/11/2019
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2013 Scott H, Wood LG, Garg ML, Gibson PG, 'Asthma and Inflammation', Nutrition and Physical activity in inflammatory diseases, CABI, Oxford, UK 299-321 (2013) [B1]
Co-authors Lisa Wood, Manohar Garg, Peter Gibson

Journal article (29 outputs)

Year Citation Altmetrics Link
2021 Niessen NM, Gibson PG, Simpson JL, Scott HA, Baines KJ, Fricker M, 'Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma.', ERJ Open Res, 7 (2021)
DOI 10.1183/23120541.00131-2021
Co-authors Katherine Baines, Michael Fricker, Jodie Simpson, Peter Gibson
2021 Niessen NM, Baines KJ, Simpson JL, Scott HA, Qin L, Gibson PG, Fricker M, 'Neutrophilic asthma features increased airway classical monocytes', CLINICAL AND EXPERIMENTAL ALLERGY, 51 305-317 (2021)
DOI 10.1111/cea.13811
Citations Scopus - 2Web of Science - 2
Co-authors Michael Fricker, Jodie Simpson, Katherine Baines, Peter Gibson
2021 Fricker M, Qin L, Sánchez-Ovando S, Simpson JL, Baines KJ, Riveros C, et al., 'An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype.', Allergy, (2021)
DOI 10.1111/all.15087
Co-authors Peter Wark, Lisa Wood, Carlos Riveros, Peter Gibson, Jodie Simpson, Michael Fricker
2020 Fricker M, Qin L, Niessen N, Baines KJ, McDonald VM, Scott HA, et al., 'Relationship of sputum mast cells with clinical and inflammatory characteristics of asthma', CLINICAL AND EXPERIMENTAL ALLERGY, 50 696-707 (2020) [C1]
DOI 10.1111/cea.13609
Citations Scopus - 6Web of Science - 7
Co-authors Michael Fricker, Jodie Simpson, Katherine Baines, Peter Gibson, Vanessa Mcdonald
2020 Simpson JL, Scott HA, 'What does the increasing prevalence of obesity mean for the management of asthma and airways disease?', JORNAL BRASILEIRO DE PNEUMOLOGIA, 46 (2020)
DOI 10.1590/1806-3713/e20200048
Citations Scopus - 2Web of Science - 2
Co-authors Jodie Simpson
2019 Williams LM, Scott HA, Wood LG, 'Soluble fibre as a treatment for inflammation in asthma', Journal of Nutrition and Intermediary Metabolism, 18 (2019) [C1]
DOI 10.1016/j.jnim.2019.100108
Citations Scopus - 2
Co-authors Lisa Wood
2019 Stoodley I, Garg M, Scott H, Macdonald-Wicks L, Berthon B, Wood L, 'Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study.', Nutrients, 12 (2019) [C1]
DOI 10.3390/nu12010074
Citations Scopus - 8Web of Science - 8
Co-authors Lisa Wood, Manohar Garg, Lesley Wicks, Bronwyn Berthon
2019 Wood LG, Li Q, Scott HA, Rutting S, Berthon BS, Gibson PG, et al., 'Saturated fatty acids, obesity, and the nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in asthmatic patients', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143 305-315 (2019) [C1]
DOI 10.1016/j.jaci.2018.04.037
Citations Scopus - 33Web of Science - 29
Co-authors Jodie Simpson, Philip Hansbro, Evan J Williams, Lisa Wood, Jay Horvat, Bronwyn Berthon, Peter Gibson, Katherine Baines
2019 Stoodley I, Williams L, Thompson C, Scott H, Wood L, 'Evidence for lifestyle interventions in asthma', Breathe, 15 e50-e61 (2019) [C1]

Asthma is a chronic inflammatory airways disease, estimated to affect 300 million people worldwide. Asthma management plans focus on optimisation of asthma pharmacotherapy. Lifest... [more]

Asthma is a chronic inflammatory airways disease, estimated to affect 300 million people worldwide. Asthma management plans focus on optimisation of asthma pharmacotherapy. Lifestyle interventions also hold great promise for asthma sufferers as they are accessible, low cost and have minimal side-effects, thus making adherence more likely. This review explores lifestyle interventions that have been tested in asthma, including improving nutrition, increasing physical activity and introduction of relaxation therapies such as yoga and massage therapy. Available evidence suggests a protective effect of increasing fruit, vegetable and wholegrain intake and increasing physical activity levels in asthma. Weight loss is recommended for obese asthmatic patients, as just 5¿10% weight loss has been found to improve quality of life and asthma control in most obese asthmatic patients. Other lifestyle interventions such as meditation, yoga and massage therapy show promise, with positive effects on asthma seen in some studies. However, the study protocols are highly variable and the results are inconsistent. Additional research is needed to further develop and refine recommendations regarding lifestyle modifications that can be implemented to improve asthma.

DOI 10.1183/20734735.0019-2019
Citations Scopus - 7
Co-authors Lisa Wood
2017 Scott HA, Wood LG, Gibson PG, 'Role of Obesity in Asthma: Mechanisms and Management Strategies', Current Allergy and Asthma Reports, 17 1-10 (2017) [C1]
DOI 10.1007/s11882-017-0719-9
Citations Scopus - 25Web of Science - 25
Co-authors Peter Gibson, Lisa Wood
2017 Guilleminault L, Williams EJ, Scott HA, Berthon BS, Jensen M, Wood LG, 'Diet and Asthma: Is It Time to Adapt Our Message?', Nutrients, 9 (2017) [C1]
DOI 10.3390/nu9111227
Citations Scopus - 57Web of Science - 60
Co-authors Lisa Wood, Megan Jensen, Bronwyn Berthon, Evan J Williams
2017 McLoughlin RF, McDonald VM, Gibson PG, Scott HA, Hensley MJ, MacDonald-Wicks L, Wood LG, 'The Impact of a Weight Loss Intervention on Diet Quality and Eating Behaviours in People with Obesity and COPD.', Nutrients, 9 1-14 (2017) [C1]
DOI 10.3390/nu9101147
Citations Scopus - 4Web of Science - 4
Co-authors Bec Mcloughlin, Lisa Wood, Vanessa Mcdonald, Peter Gibson, Michael Hensley, Lesley Wicks
2016 Scott HA, Gibson PG, Garg ML, Upham JW, Wood LG, 'Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype', Allergy: European Journal of Allergy and Clinical Immunology, 71 1037-1047 (2016) [C1]

Background Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese-asthma phenotype. The aim of this study was to examine the associatio... [more]

Background Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese-asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with asthma. Methods Obese (n = 39) and nonobese (n = 42) females and obese (n = 24) and nonobese (n = 25) males with asthma were recruited. Females were further categorized as reproductive-aged (<50 years old; n = 36) or older (>50 years old; n = 45). Thirteen (36.1%) reproductive-aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers. Results Obese reproductive-aged females had higher sputum %neutrophils than nonobese reproductive-aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C-reactive protein and IL-6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive-aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015). Conclusions This study suggests that sex hormones and systemic inflammation may be mediating the obese-asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive-aged females warrants further investigation.

DOI 10.1111/all.12891
Citations Scopus - 30Web of Science - 31
Co-authors Peter Gibson, Manohar Garg, Lisa Wood
2016 Ballantyne D, Scott H, MacDonald-Wicks L, Gibson PG, Wood LG, 'Resistin is a predictor of asthma risk and resistin:adiponectin ratio is a negative predictor of lung function in asthma', Clinical and Experimental Allergy, 46 1056-1065 (2016) [C1]

Background: Adipokines, such as resistin and adiponectin, modify inflammation and may contribute to increased asthma risk and severity in obese people. Objective: To examine plasm... [more]

Background: Adipokines, such as resistin and adiponectin, modify inflammation and may contribute to increased asthma risk and severity in obese people. Objective: To examine plasma resistin and resistin:adiponectin ratio (i) in asthmatics compared to healthy controls, (ii) according to asthma severity, obesity and gender (iii) following weight loss in obese asthmatics. Methods: In a cross-sectional observational study of asthmatic adults (n = 96) and healthy controls (n = 46), plasma resistin and adiponectin were measured. In a separate intervention study, obese asthmatic adults (n = 27) completed a 10-week weight loss intervention and plasma resistin and adiponectin concentrations were analysed. Results: Plasma resistin and resistin:adiponectin ratio were higher in asthma compared to controls and were higher again in subjects with a severe vs. mild-to-moderate asthma pattern. Amongst asthmatic subjects, resistin was not modified by gender or obesity, while adiponectin was lower in males and obese subjects. As a result, resistin:adiponectin ratio was higher in obese males, non-obese males and obese females, compared to non-obese females. In a logistic regression model, plasma resistin concentration was a predictor of asthma risk. In a multiple linear regression model, plasma resistin:adiponectin ratio was a negative predictor of FEV1 in asthma. Following weight loss, neither resistin, adiponectin nor resistin:adiponectin ratio was changed. However, the change (¿) in %body fat was associated with ¿ resistin:adiponectin ratio. Post-intervention ¿ resistin was negatively correlated with both ¿FRC and ¿RV. Conclusion and clinical relevance: This study demonstrates that resistin and resistin:adiponectin ratio are higher in asthma and are higher again in subjects who have more severe disease. Resistin:adiponectin ratio is highest in obese male asthmatics. As resistin is a predictor of asthma risk and resistin:adiponectin is a predictor of FEV1 in asthma, these adipokines may be contributing to the obese asthma phenotype, thus providing a potential therapeutic target for obese asthma.

DOI 10.1111/cea.12742
Citations Scopus - 21Web of Science - 23
Co-authors Peter Gibson, Lisa Wood, Lesley Wicks
2016 McDonald VM, Gibson PG, Scott HA, Baines PJ, Hensley MJ, Pretto JJ, Wood LG, 'Should we treat obesity in COPD? The effects of diet and resistance exercise training', Respirology, 21 875-882 (2016) [C1]

Background and objective: Obesity is an established risk factor for poor health outcomes, but paradoxically in chronic obstructive pulmonary disease (COPD), it is associated with ... [more]

Background and objective: Obesity is an established risk factor for poor health outcomes, but paradoxically in chronic obstructive pulmonary disease (COPD), it is associated with improved survival and lung function. A major evidence gap exisits to inform treatment recommendations for patients with COPD who are obese. We aimed to determine the effect of weight reduction involving a low-energy diet utilizing a partial meal replacement plan, coupled with resistance exercise training in obese COPD patients. Methods: In a proof of concept before¿after clinical trial, obese (body mass index =30 kg/m2) COPD patients received a 12 week weight reduction programme involving meal replacements, dietary counselling by a dietitian and resistance exercise training prescribed and supervised by a physiotherapist. Patients were reviewed face to face by the dietitian and physiotherapist every 2 weeks for counselling. Results: Twenty-eight participants completed the intervention. Mean (standard deviation) body mass index was 36.3 kg/m2 (4.6) at baseline and reduced by 2.4 kg/m2 ((1.1) P < 0.0001) after the intervention. Importantly, skeletal muscle mass was maintained. Clinical outcomes improved with weight loss including exercise capacity, health status, dyspnea, strength and functional outcomes. There was also a significant reduction in the body mass index, obstruction, dyspnea and exercise score (BODE). Systemic inflammation measured by C-reactive protein however did not change. Conclusion: In obese COPD patients, dietary energy restriction coupled with resistance exercise training results in clinically significant improvements in body mass index, exercise tolerance and health status, whilst preserving skeletal muscle mass. This novel study provides a framework for development of guidelines for the management of obese COPD patients and in guiding future research.

DOI 10.1111/resp.12746
Citations Scopus - 33Web of Science - 35
Co-authors Peter Gibson, Michael Hensley, Vanessa Mcdonald, Lisa Wood
2016 Scott HA, Wood LG, Gibson PG, 'What About Neutrophils in Obese Asthma?', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 55 462-462 (2016)
DOI 10.1165/rcmb.2016-0085LE
Citations Scopus - 3Web of Science - 3
Co-authors Lisa Wood, Peter Gibson
2015 Periyalil HA, Wood LG, Scott HA, Jensen ME, Gibson PG, 'Macrophage activation, age and sex effects of immunometabolism in obese asthma', European Respiratory Journal, 45 388-395 (2015) [C1]

Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometa... [more]

Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometabolism in obese asthma. Obese and non-obese asthmatic children and adults underwent spirometry, body composition assessment by dual energy X-ray absorptiometry and measurement of serum soluble CD163 (sCD163), tryptase, C-reactive protein (CRP) and other adipocytokines. Plasma CRP (p<0.01) and leptin (p<0.01) were elevated in obese asthmatic adults, and sCD163 (p=0.003) was elevated in obese asthmatic children. We observed significantly higher sCD163 in obese female children compared to obese female adults and male children, and higher CRP in obese female adults compared to obese male children and adults. Serum tryptase concentrations were not significantly different across age groups. sCD163 positively correlated with the proportion of android fat in obese female children (r=0.70, p=0.003) and obese female adults (r=0.65, p=0.003). In obese female children, sCD163 was inversely associated with forced expiratory volume in 1 s % predicted (r=-0.55, p=0.02) and was positively associated with the Asthma Control Questionnaire (r=0.57, p=0.02). Obese children with asthma have sex-specific macrophage activation, which may contribute to worse asthma control and lung function. The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level.

DOI 10.1183/09031936.00080514
Citations Scopus - 27Web of Science - 25
Co-authors Megan Jensen, Lisa Wood, Peter Gibson
2015 Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, et al., 'Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma', Annals of Allergy, Asthma and Immunology, 114 470-479 (2015) [C1]

Background Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective To examin... [more]

Background Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective To examine the effects of acute exercise on inflammation in physically inactive and active adults with asthma. Methods Fourteen adults with asthma (n = 6 physically inactive, n = 8 physically active) completed (1) 30 minutes of moderate-intensity exercise on a treadmill and (2) 30 minutes of rest in random order, with 4 weeks between sessions. Exhaled nitric oxide (eNO) was measured before and after the intervention (0, 0.5, 1, 2, 4, and 24 hours). Blood inflammatory mediators were measured before and after the intervention (0, 2, and 24 hours). Results Physically inactive participants had a significant decrease in eNO 4 hours after exercise (-4.8 ppb, -6.4 to -0.5 ppb, P =.028), which was not observed in physically active participants (P =.362). Interluekin-1 receptor antagonist increased in the physically inactive group 2 hours after exercise, with this increase strongly correlated with the decrease in eNO at 4 hours (R = -0.685, P =.007) and 24 hours (R = -0.659, P =.014) after exercise. Interleukin-6 was increased significantly 2 hours after exercise in physically inactive participants. Blood neutrophils and nuclear factor erythroid 2-like 2 gene expression were increased 2 hours after exercise in the overall cohort. Conclusion This study demonstrates that acute moderate-intensity exercise is associated with decreased eNO in physically inactive adults with asthma and suggests that interluekin-1 receptor antagonist could have a role in mediating this effect. The attenuated response in physically active participants might be due to the sustained anti-inflammatory effects of exercise training. Future studies should investigate the impact of exercise intensity and exercise training on airway inflammation in those with asthma.

DOI 10.1016/j.anai.2015.04.002
Citations Scopus - 19Web of Science - 17
Co-authors Robin Callister, Katherine Baines, Lisa Wood
2015 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Determinants of weight loss success utilizing a meal replacement plan and/or exercise, in overweight and obese adults with asthma', Respirology, 20 243-250 (2015) [C1]

Background and objective While weight loss has been shown to reduce obesity-related comorbidity, many weight loss treatments fail. Factors that enhance weight loss success are unk... [more]

Background and objective While weight loss has been shown to reduce obesity-related comorbidity, many weight loss treatments fail. Factors that enhance weight loss success are unknown, particularly in those with asthma. The aim of the study was to identify patient characteristics that predict weight loss success in adults with asthma. Methods Baseline and change in asthma characteristics and eating behaviours were investigated for relationships with weight loss and fat loss using multiple linear regression, in 38 overweight and obese adults with asthma randomized to dietary, exercise or combined interventions targeting weight loss for 10 weeks. Results Mean ± standard deviation weight loss was 6.6 ± 5.1 kg. Greater %weight loss and %fat loss was achieved in those with poorer asthma-related quality of life at baseline ((rs = 0.398, P = 0.015) and (rs = 0.455, P = 0.005) respectively), with 1.7% greater absolute weight loss at week 10 corresponding to each one unit reduction in the asthma-related quality of life score at baseline. Furthermore, a lower baseline forced expiratory volume in 1 s/forced vital capacity correlated with greater weight loss (rs = 0.398, P = 0.015). Male sex was associated with a 3.6 kg greater weight loss (P = 0.087). Reducing emotional eating during the programme was associated with greater weight loss in women (rs = 0.576, P = 0.010). Conclusions This study demonstrates that individuals with more severe asthma at baseline are more successful in achieving weight loss, which could be a consequence of greater motivation and could be used as a motivational tool within the clinical setting. Gender tailoring of weight loss programmes may be useful to enhance weight loss success. Future studies are urgently needed to establish predictors of long-term weight loss maintenance in those with asthma. See Editorial, page 179 This study is the first to demonstrate that more severe asthma at baseline, male sex, and improvements in eating behaviours during weight loss are associated with greater weight loss success in overweight and obese adults with asthma. Our findings may inform the development of asthma-specific weight management guidelines.

DOI 10.1111/resp.12423
Citations Scopus - 13Web of Science - 13
Co-authors Philip Morgan, Robin Callister, Lisa Wood, Manohar Garg, Peter Gibson
2014 Scott HA, Jensen ME, Wood LG, 'Dietary interventions in asthma', Current Pharmaceutical Design, 20 1003-1010 (2014) [C1]

Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immu... [more]

Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immune system, via a predominantly IL-5 mediated, eosinophilic pathway. Stimuli such as viruses and bacteria activate the innate immune system, via a predominantly IL-8 mediated, neutrophilic pathway. Asthma has also been demonstrated to involve a systemic inflammatory component. Glucocorticoids are the predominant pharmacological treatment used to control inflammation in asthma. However, compliance with medications can be compromised due to patient concerns about side effects. Hence dietary interventions that target the inflammatory response in asthma have great potential. Various aspects of dietary intake are known to modulate inflammation. Saturated fatty acids can induce an inflammatory response via activation of pattern recognition receptors. Omega-3 fatty acids can be anti-inflammatory, via mechanisms such as modification of eicosanoid production. Antioxidants can have anti-inflammatory effects as they scavenge free radicals, preventing activation of transcription factors including NF-¿B. Chronic excess energy intake can lead to obesity, which augments inflammation due to the release of inflammatory mediators by adipose tissue. Here we review the role of these dietary components in asthma. © 2014 Bentham Science Publishers.

DOI 10.2174/13816128113190990421
Citations Scopus - 15Web of Science - 13
Co-authors Lisa Wood, Megan Jensen
2014 Morgan PJ, Scott HA, Young MD, Plotnikoff RC, Collins CE, Callister R, 'Associations between program outcomes and adherence to Social Cognitive Theory tasks: process evaluation of the SHED-IT community weight loss trial for men', INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY, 11 (2014) [C1]
DOI 10.1186/s12966-014-0089-9
Citations Scopus - 21Web of Science - 14
Co-authors Ron Plotnikoff, Philip Morgan, Robin Callister, Myles Young, Clare Collins
2013 Morgan PJ, Barnett LM, Cliff DP, Okely AD, Scott HA, Cohen KE, Lubans DR, 'Fundamental movement skill interventions in youth: A systematic review and meta-analysis', Pediatrics, 132 (2013) [C1]
DOI 10.1542/peds.2013-1167
Citations Scopus - 193Web of Science - 180
Co-authors Philip Morgan, David Lubans
2013 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial', Clinical and Experimental Allergy, 43 36-49 (2013) [C1]
DOI 10.1111/cea.12004
Citations Scopus - 157Web of Science - 149
Co-authors Manohar Garg, Lisa Wood, Robin Callister, Peter Gibson, Philip Morgan
2012 Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized controlled trial', American Journal of Clinical Nutrition, 96 534-543 (2012) [C1]
DOI 10.3945/ajcn.111.032623
Citations Scopus - 135Web of Science - 124
Co-authors Daniel Barker, Manohar Garg, Peter Gibson, Lisa Wood
2012 Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma', Chest, 142 86-93 (2012) [C1]
Citations Scopus - 185Web of Science - 171
Co-authors Lisa Wood, Peter Gibson, Katherine Baines
2012 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Relationship between body composition, inflammation and lung function in overweight and obese asthma', Respiratory Research, 13 1-10 (2012) [C1]
Citations Scopus - 33Web of Science - 34
Co-authors Lisa Wood, Philip Morgan, Robin Callister, Manohar Garg, Peter Gibson
2011 Scott HA, Gibson PG, Garg ML, Wood LG, 'Airway inflammation is augmented by obesity and fatty acids in asthma', European Respiratory Journal, 38 594-602 (2011) [C1]
DOI 10.1183/09031936.00139810
Citations Scopus - 190Web of Science - 179
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
2009 Wood LG, Scott HA, Garg ML, Gibson PG, 'Innate immune mechanisms linking non-esterified fatty acids and respiratory disease', Progress in Lipid Research, 48 27-43 (2009) [C1]
DOI 10.1016/j.plipres.2008.10.001
Citations Scopus - 43Web of Science - 41
Co-authors Manohar Garg, Lisa Wood, Peter Gibson
2009 McFarlane J, Scott HA, Robertson VJ, Gleeson C, Vanderkroft D, Wilson K, 'General practitioner and paediatrician self-reported capacity for the diagnosis and management of childhood and adolescent overweight and obesity', Nutrition & Dietetics, 66 176-185 (2009) [C1]
DOI 10.1111/j.1747-0080.2009.01363.x
Citations Scopus - 5Web of Science - 5
Show 26 more journal articles

Conference (47 outputs)

Year Citation Altmetrics Link
2021 Fricker M, Qin L, Sanchez-Ovando S, Simpson J, Baines K, Riveros C, et al., 'SPUTUM MACROPHAGES ARE TRANSCRIPTOMICALLY ALTERED IN NEUTROPHILIC ASTHMA', RESPIROLOGY (2021)
Co-authors Jodie Simpson, Carlos Riveros, Peter Gibson, Katherine Baines, Michael Fricker
2021 Valkenborghs S, Wood L, Callister R, Upham J, Grainge C, Anderson S, et al., 'BOTH MODERATE-INTENSITY AND VIGOROUS-INTENSITY AEROBIC EXERCISE TRAINING ARE ASSOCIATED WITH IMPROVEMENTS IN ASTHMA', RESPIROLOGY (2021)
Co-authors Robin Callister, Lisa Wood, Christopher Grainge, Sarah Valkenborghs
2020 Fricker M, Niessen N, Baines K, Simpson J, Scott H, Gibson P, 'Neutrophilic asthma features increased airway classical monocytes', EUROPEAN RESPIRATORY JOURNAL (2020)
DOI 10.1183/13993003.congress-2020.1109
Co-authors Michael Fricker, Jodie Simpson, Peter Gibson, Katherine Baines
2020 Thompson C, Berthon BS, Scott HA, Gibson PG, Young PM, Oliver BG, Wood LG, 'Macronutrient Effects on Bronchodilator Responsiveness in Obese Asthma', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ELECTR NETWORK (2020)
Co-authors Peter Gibson, Lisa Wood, Bronwyn Berthon
2020 Stoodley I, Berthon B, Scott H, Baines P, Paradzayi B, Wood L, 'Comparison of Body Composition, Strength and Function between Older Adults at Risk and Not at Risk of Sarcopenia', Proceedings, Newcastle (2020)
Co-authors Lisa Wood
2020 Ferraris C, Beckett E, Scott H, 'Sour Taste Genetics (KCNJ2) Predict Cognitive Function in the Elderly', Proceedings, Newcastle, Australia (2020)
Co-authors Emma Beckett
2020 Fricker M, Qin L, Niessen N, Baines K, Scott H, Simpson J, Gibson P, 'RELATIONSHIP OF SPUTUM MAST CELLS WITH CLINICAL AND INFLAMMATORY CHARACTERISTICS OF ASTHMA.', RESPIROLOGY (2020)
Citations Web of Science - 7
Co-authors Katherine Baines, Michael Fricker, Jodie Simpson, Peter Gibson
2019 McDiarmid K, Upham J, Wood L, MacDonald-Wicks L, Nitin S, Hebert J, Scott H, 'An anti-inflammatory meal post-exercise augments the exercise-induced reduction in airway inflammation in adults with asthma', Proceedings, Canberra, Australia (2019)
Co-authors Lisa Wood, Lesley Wicks
2019 Thompson C, Berthon B, Scott H, Gibson P, Young P, Oliver P, Wood L, 'The effects of macronutrients on bronchodilator responsiveness in asthma', Proceedings, Canberra, Australia (2019)
Co-authors Lisa Wood, Peter Gibson, Bronwyn Berthon
2019 Stoodley I, Garg M, Scott H, MacDonald-Wicks L, Berthon B, Wood L, 'A higher omega-3 index in associated with better asthma control', Proceedings, Canberra, Australia (2019)
Co-authors Lesley Wicks, Manohar Garg, Bronwyn Berthon, Lisa Wood
2019 Thompson C, Berthon B, Scott H, Gibson P, Young P, Oliver B, Wood L, 'MACRONUTRIENT EFFECTS ON BRONCHODILATOR RESPONSIVENESS IN OBESE ASTHMA', RESPIROLOGY (2019)
Co-authors Bronwyn Berthon, Peter Gibson, Lisa Wood
2018 Scott H, Wood L, Upham J, 'A single bout of moderate-intensity exercise reduces eosinophilic airway inflammation in inactive adults with asthma, while vigorous-intensity exercise has no effect', Proceedings, Adelaide, Australia (2018)
Co-authors Lisa Wood
2017 Wood LG, Li Q, Scott HA, Berthon BS, Gibson PG, Baines KA, 'Saturated Fatty Acids, But Not N-6 Polyunsaturated Fatty Acids Or Carbohydrates, Increase Airway Inflammation In Non-Obese Asthmatics', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Washington, DC (2017)
Co-authors Peter Gibson, Katherine Baines, Bronwyn Berthon, Lisa Wood
2016 Wood L, Ballantyne D, Scott H, Mcdonald-Wicks L, Gibson P, 'RESISTIN AND RESISTIN : ADIPONECTIN RATIO AS PREDICTORS OF LUNG FUNCTION IN ASTHMA', RESPIROLOGY (2016)
Co-authors Peter Gibson
2016 Scott H, Gibson P, Grag M, Upham J, Wood L, 'SEX HORMONES AND SYSTEMIC CYTOKINES ARE INDEPENDENT MODULATORS OF THE OBESE-ASTHMA PHENOTYPE', RESPIROLOGY (2016)
Co-authors Peter Gibson
2016 Zapirain R, McDonald V, Scott H, MacDonald-Wicks L, Gibson P, Hensley M, Wood L, 'Evaluation of a weight-loss intervention in obese chronic obstructive pulmonary disease (COPD) participants', Journal of Nutrition and Intermediary Metabolism, Wellington, New Zealand (2016)
Co-authors Lesley Wicks, Vanessa Mcdonald, Lisa Wood, Peter Gibson, Michael Hensley
2016 Wood LG, Ballantyne D, Scott H, McDonald-Wicks L, Gibson PG, 'Lung Function Is Predicted By Resistin And Resistin: Adiponectin Ratio In Asthma', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, San Francisco, CA (2016)
Co-authors Lisa Wood, Peter Gibson
2016 Wood LG, Ballantyne D, Scott HA, MacDonald-Wicks L, Gibson PG, 'Resistin and resistin:adiponectin ratio predict lung function in asthma', Journal of Nutrition & Intermediary Metabolism (2016)
DOI 10.1016/j.jnim.2015.12.201
2015 Scott H, Latham J, Callister R, Pretto J, Saltos N, Upham J, Wood L, 'A SINGLE BOUT OF EXERCISE IS ASSOCIATED WITH A TRANSIENT REDUCTION TO EXHALED NITRIC OXIDE IN PHYSICALLY INACTIVE ADULTS WITH ASTHMA', RESPIROLOGY, Queensland, AUSTRALIA (2015) [E3]
Co-authors Lisa Wood, Robin Callister
2014 Morgan P, Scott H, Young M, Callister R, Collins C, Plotnikoff R, 'Process evaluation of the SHED-IT community weight loss program for men: program engagement and its association with changes to weight, physical activity and dietary intake', Obesity Reviews, Kuala Lumpur, Malaysia (2014)
Co-authors Robin Callister, Clare Collins, Philip Morgan, Ron Plotnikoff
2014 Scott H, Gibson P, Garg M, Smart J, Wood L, 'Reproductive Stage Drives The Association Between Obesity and Asthma in Females', Obesity Reviews, Kuala Lumpur, Malaysia (2014)
Co-authors Lisa Wood, Manohar Garg, Peter Gibson
2014 Periyalil H, Scott H, Jensen M, Wood L, Gibson P, 'MACROPHAGE ACTIVATION IS A DETERMINANT OF DEVELOPMENTAL EFFECTS OF IMMUNOMETABOLISM IN OBESE ASTHMA', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_7
Co-authors Megan Jensen, Lisa Wood, Peter Gibson
2014 Mcdonald V, Gibson P, Scott H, Baines P, Hensley M, Pretto J, Wood L, 'SHOULD WE TREAT OBESITY IN COPD? THE EFFECTS OF WEIGHT LOSS AND RESISTANCE TRAINING IN OBESE COPD', RESPIROLOGY (2014) [E3]
Co-authors Lisa Wood, Michael Hensley, Peter Gibson, Vanessa Mcdonald
2013 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Female Reproductive Stage Drives The Association Between Obesity And Neutrophilic Airway Inflammation In Adults With Asthma', American Journal of Respiratory and Critical Care Medicine, Philadelphia, PA (2013) [E3]
Co-authors Lisa Wood, Manohar Garg, Peter Gibson
2013 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'The Association Between Obesity and Asthma is Driven By Female Reproductive Stage', Australasian Medical Journal, Brisbane (2013) [E3]
Co-authors Lisa Wood, Manohar Garg, Peter Gibson
2013 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'REPRODUCTIVE STAGE DRIVES LINK BETWEEN OBESITY AND NEUTROPHILIC AIRWAY INFLAMMATION IN FEMALES WITH ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Lisa Wood, Peter Gibson, Manohar Garg
2012 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Female reproductive stage drives the association between obesity and neutrophilic airway inflammation in adults with asthma', Abstracts. American Thoracic Society 2012 International Conference, San Francisco, CA (2012) [E3]
Co-authors Peter Gibson, Manohar Garg, Lisa Wood
2012 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Reproductive stage drives link between obesity and neutrophilic airway inflammation in females with asthma', Abstracts. TSANZ Annual Scientific Meeting 2012, Canberra, ACT (2012) [E3]
Co-authors Manohar Garg, Peter Gibson, Lisa Wood
2012 Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized clinical trial', Respirology, Canberra, ACT (2012) [E3]
Citations Web of Science - 2
Co-authors Peter Gibson, Manohar Garg, Lisa Wood
2012 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Weight loss improves clinical asthma outcomes and airway inflammation in overweight and obese asthmatics', Obesity Research & Clinical Practice, Auckland, New Zealand (2012) [E3]
Co-authors Peter Gibson, Lisa Wood, Manohar Garg, Philip Morgan, Robin Callister
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'The influence of body composition and inflammation on lung function in asthma', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authors Philip Morgan, Robin Callister, Lisa Wood, Peter Gibson, Manohar Garg
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved after body fat reduction in overweight and obese asthmatics', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Manohar Garg, Peter Gibson, Philip Morgan, Robin Callister, Lisa Wood
2011 Wood LG, Scott HA, Gibson PG, 'Systemic inflammation is increased in neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Peter Gibson, Lisa Wood
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is greatest in subjects with more severe asthma', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Manohar Garg, Lisa Wood, Robin Callister, Philip Morgan, Peter Gibson
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is related to asthma severity', Respirology, Perth, WA (2011) [E3]
Co-authors Peter Gibson, Manohar Garg, Lisa Wood, Philip Morgan, Robin Callister
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Body fat reduction improves clinical asthma outcomes in overweight and obese asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Manohar Garg, Peter Gibson, Philip Morgan, Robin Callister, Lisa Wood
2011 Wood LG, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated increased systemic inflammation in asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Peter Gibson, Lisa Wood
2011 Fu J, Baines KJ, Wood LG, Scott HA, Gibson PG, 'Low-grade systemic inflammation is associated with airway neutrophilia in asthma', Respirology, Shanghai (2011) [E3]
Co-authors Peter Gibson, Lisa Wood, Katherine Baines
2011 Fu J, Baines KJ, Gibson PG, Scott HA, Wood LG, 'Systemic inflammation mediates airway neutrophilia via the regulation of IL-8 receptor mRNA expression', Respirology, Shanghai (2011) [E3]
Co-authors Peter Gibson, Katherine Baines, Lisa Wood
2010 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Fatty acids and obesity differentially affect airway inflammation in males and females with asthma', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Co-authors Lisa Wood, Peter Gibson, Manohar Garg
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric restriction and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research & Clinical Practice, Sydney, NSW (2010) [E3]
Co-authors Manohar Garg, Lisa Wood, Robin Callister, Peter Gibson, Philip Morgan
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric consumption and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research and Clinical Practice, Sydney, NSW (2010) [E3]
Co-authors Philip Morgan, Peter Gibson, Manohar Garg, Lisa Wood, Robin Callister
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved by caloric restriction and exercise in overweight and obese asthma', Proceedings of the Nutrition Society of Australia, Perth (2010) [E3]
Co-authors Manohar Garg, Lisa Wood, Robin Callister, Philip Morgan, Peter Gibson
2009 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Plasma fatty acid profiles are different in obese versus non-obese asthma', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authors Peter Gibson, Manohar Garg, Lisa Wood
2009 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Neutrophilic Airway Inflammation Links Asthma and Obesity', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
2009 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Asthma and obesity are linked via neutrophilic airway inflammation', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Gibson, Manohar Garg, Lisa Wood
2008 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Obesity is associated with increased inflammation in asthma', Asia Pacific Journal of Clinical Nutrition, Adelaide, SA (2008) [E3]
Co-authors Lisa Wood, Peter Gibson, Manohar Garg
Show 44 more conferences
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Grants and Funding

Summary

Number of grants 21
Total funding $826,720

Click on a grant title below to expand the full details for that specific grant.


20211 grants / $18,182

Exploring the link between female sex hormones and asthma: a clinical trial $18,182

Funding body: Hunter New England Local Health District

Funding body Hunter New England Local Health District
Project Team Doctor Hayley Scott, Professor Lisa Wood, Doctor Geoff Tyler
Scheme John Hunter Hospital Charitable Trust Grant
Role Lead
Funding Start 2021
Funding Finish 2021
GNo G2100227
Type Of Funding C2400 – Aust StateTerritoryLocal – Other
Category 2400
UON Y

20201 grants / $5,000

Academic Staff Leave Support Grant$5,000

Funding body: Faculty of Health and Medicine Equity, Diversity and Inclusion Committee, The University of Newcastle

Funding body Faculty of Health and Medicine Equity, Diversity and Inclusion Committee, The University of Newcastle
Project Team

Doctor Hayley Scott

Scheme Academic Leave Support Grant
Role Lead
Funding Start 2020
Funding Finish 2020
GNo
Type Of Funding Internal
Category INTE
UON N

20192 grants / $92,225

Understanding female sex hormones in asthma$60,000

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team Doctor Hayley Scott
Scheme TSANZ/AstraZeneca - Respiratory Research Fellowship
Role Lead
Funding Start 2019
Funding Finish 2019
GNo G1900822
Type Of Funding C3200 – Aust Not-for Profit
Category 3200
UON Y

Understanding how exercise improves asthma$32,225

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Hayley Scott, Professor Lisa Wood, Conjoint Professor Robin Callister, Doctor Sarah Valkenborghs, Doctor Geoff Tyler
Scheme Research Grant
Role Lead
Funding Start 2019
Funding Finish 2020
GNo G1900260
Type Of Funding C2400 – Aust StateTerritoryLocal – Other
Category 2400
UON Y

20182 grants / $105,000

Exercise, diet and obesity for asthma management: it’s time to weigh up our options$60,000

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team Doctor Hayley Scott
Scheme TSANZ/National Asthma Council Australia - Asthma and Airways Career Development Fellowship
Role Lead
Funding Start 2018
Funding Finish 2018
GNo G1701493
Type Of Funding C3200 – Aust Not-for Profit
Category 3200
UON Y

Acute Exercise in Adults with Asthma: Establishing the roles of inflammation, oxidative stress and endogenous antioxidants$45,000

Funding body: Priority Research Centre (PRC) for Healthy Lungs | The University of Newcastle

Funding body Priority Research Centre (PRC) for Healthy Lungs | The University of Newcastle
Project Team

Doctor Hayley Scott

Scheme PRC Healthy Lungs Outstanding Scholar Award
Role Lead
Funding Start 2018
Funding Finish 2018
GNo
Type Of Funding Internal
Category INTE
UON N

20172 grants / $84,175

CLARIOstar high performance microplate reader$66,175

Funding body: Hunter Medical Research Institute (HMRI)

Funding body Hunter Medical Research Institute (HMRI)
Project Team

Doctor Katie Baines, Professor Jodie Simpson, Professor Lisa Wood, Professor Peter Gibson, Doctor Vanessa Murphy, Doctor Hayley Scott

Scheme Hunter Medical Research Institute
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding C3112 - Aust Not for profit
Category 3112
UON N

Investigating the role of exercise in people with asthma$18,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Hayley Scott
Scheme Women in Research Fellowship
Role Lead
Funding Start 2017
Funding Finish 2018
GNo G1701404
Type Of Funding Internal
Category INTE
UON Y

20151 grants / $150,000

Improving asthma through lifestyle interventions: how much exercise is best?$150,000

Funding body: Asthma Australia

Funding body Asthma Australia
Project Team

Professor John Upham, Doctor Hayley Scott, Professor Lisa Wood

Scheme National Research Program
Role Investigator
Funding Start 2015
Funding Finish 2019
GNo
Type Of Funding C3100 – Aust For Profit
Category 3100
UON N

20146 grants / $227,648

Understanding the Beneficial Role of Exercise in Modifying Eosinophilic Airway Inflammation in Asthma$160,000

This project will examine the concept that exercise assists in optimising asthma management. While it is well established that exercise has multiple benefits on general health, relatively little attention has been paid to the potential therapeutic effects of exercise in modifying inflammation in asthma. We have recently published a study showing that moderate-intensity aerobic exercise can reduce airway eosinophilia in adults with asthma. This project will build on this exciting data, by examining the importance of exercise intensity and assessing the mechanisms through which exercise exerts these beneficial effects.

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team

Dr Hayley Scott

Scheme Postdoctoral Respiratory Research Fellowship
Role Lead
Funding Start 2014
Funding Finish 2016
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

Greaves Family Early Career Support Grant$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Hayley Scott
Scheme Bridging Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301292
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Exercise Training as a Potential Treatment for Eosinophilic Airway Inflammation in Asthma$26,648

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Hayley Scott, Professor Lisa Wood, Conjoint Associate Professor Nick Saltos
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400219
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Centrifuge Rotor$7,000

Funding body: Faculty of Health and Medicine Research Equipment Grant Round

Funding body Faculty of Health and Medicine Research Equipment Grant Round
Project Team

Professor Lisa Wood, Professor Peter Gibson, Professor Peter Wark, Professor Clare Collins, Professor Robin Callister, Professor Vanessa McDonald, Professor Joerg Mattes, Doctor Katie Baines, Doctor Hayley Scott, Professor Lesley McDonald-Wicks

Scheme Faculty of Health and Medicine Research Equipment Grant Round
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo
Type Of Funding Internal
Category INTE
UON N

12th International congress on Obesity, Kuala Lumpur Malaysia, 17-20 March 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Hayley Scott
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400427
Type Of Funding Internal
Category INTE
UON Y

Early Career Travel Grant$2,000

Funding body: Nutrition Society of Australia

Funding body Nutrition Society of Australia
Project Team

Doctor Hayley Scott

Scheme Early Career Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo
Type Of Funding C3100 – Aust For Profit
Category 3100
UON N

20131 grants / $23,810

The Effect of Exercise on Asthmatic Airway Inflammation$23,810

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Hayley Scott, Conjoint Associate Professor Nick Saltos
Scheme Research Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300780
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20123 grants / $52,909

Bioimpedance Analyser – InBody 720 $28,000

Funding body: Faculty of Health and Medicine Research Equipment Grant Round

Funding body Faculty of Health and Medicine Research Equipment Grant Round
Project Team

Prof Vanessa McDonald, Prof Peter Gibson, Prof Peter Wark, Prof Jodie Simpson, Dr Katie Baines, Dr Vanessa Murphy, Prof Lisa Wood, Dr Hayley Scott et al

Scheme Faculty of Health and Medicine Research Equipment Grant Round
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo
Type Of Funding Internal
Category INTE
UON N

Follow-Up of a Weight Loss Intervention in COPD$14,989

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Professor Lisa Wood, Doctor Hayley Scott, Emeritus Professor Michael Hensley
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200763
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The Role of Sex Hormones and Leptin in Obese-Asthma$9,920

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Hayley Scott
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200809
Type Of Funding Internal
Category INTE
UON Y

20111 grants / $1,000

Emerging Researcher of the Year$1,000

Funding body: Nutrition Society of Australia

Funding body Nutrition Society of Australia
Project Team

Doctor Hayley Scott

Scheme Travel Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo
Type Of Funding C3100 – Aust For Profit
Category 3100
UON N

20081 grants / $66,771

CCRE in Respiratory and Sleep Medicine Postgraduate Research Scholarship$66,771

Funding body: CCRE in Respiratory and Sleep Medicine

Funding body CCRE in Respiratory and Sleep Medicine
Project Team

Professor Lisa Wood, Conjoint Professor Peter Gibson, Professor Manohar Garg, Hayley Scott

Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON N
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Research Supervision

Number of supervisions

Completed8
Current1

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2018 PhD Addressing Sarcopenia in an Aging Population PhD (Nutritional Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2019 Honours Inflammatory responses of sex hormones to obesity in asthma Medical Science, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle Co-Supervisor
2019 Honours An investigation into the relationships between taste genetics, diet and indexes of anxiety, depression and cognitive function in an elderly cohort Food Science & Biotechnology, School of Environmental and Life Sciences, University of Newcastle Co-Supervisor
2018 Honours Does dietary intake modify the inflammatory response to an acute bout of exercise? Nutrition & Dietetics, School of Health Sciences, Faculty of Health and Medicine, University of Newcastle Principal Supervisor
2018 Honours Responses to Aerobic Exercise Training in Adults with Asthma Human Movement, School of Environmental and Life Sciences, University of Newcastle Co-Supervisor
2017 Honours Omega-3 Index and Asthma Nutrition & Dietetics, School of Health Sciences, Faculty of Health and Medicine, University of Newcastle Co-Supervisor
2014 Honours Evaluation of a weight loss intervention in obese COPD subjects Nutrition & Dietetics, School of Health Sciences, Faculty of Health and Medicine, University of Newcastle Co-Supervisor
2014 Honours Effect of Exercise on Asthmatic Airway Inflammation Medical Science, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle Co-Supervisor
2013 Honours Adipokines and the role in overweight and obese asthma Nutrition & Dietetics, School of Health Sciences, Faculty of Health and Medicine, University of Newcastle Co-Supervisor
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News

Women In Research Fellowships awarded

October 27, 2017

Thirteen UON researchers have been awarded a Women in Research (WIR) Fellowship thanks to Research Advantage.

Weight-loss study challenges COPD’s obesity puzzle

February 29, 2016

Faced with a clinical paradox where obesity seemingly offers a protective effect for Chronic Obstructive Pulmonary Disease (COPD), Hunter researchers have perfo

Dr Hayley Scott

Positions

Post Doctoral Research Fellow
Centre for Healthy Lungs
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Postdoctoral Research Fellow
Centre for Healthy Lungs
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Casual Lecturer
Centre for Healthy Lungs
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Casual Lecturer
Centre for Healthy Lungs
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing

Contact Details

Email hayley.scott@newcastle.edu.au
Phone 02 4042 0113
Fax 02 4042 0046
Link Twitter

Office

Room Level 2 West
Building Hunter Medical Research Institute
Location Lot 1 Kookaburra Circuit, New Lambton Heights NSW 2305

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