Associate Professor Liz Milward

Associate Professor Liz Milward

Associate Professor

School of Biomedical Sciences and Pharmacy (Medical Genetics)

Career Summary

Biography

Research Expertise
Focus Area: Medical Genetics

Qualifications

  • PhD, University of Western Australia
  • Bachelor of Science, University of Western Australia

Keywords

  • Ageing-Related Disorders
  • Anaemias
  • Iron-Related Disorders
  • Medical Genetics
  • Neurodegenerative Disorders
  • Other Biomedical Sciences

Fields of Research

Code Description Percentage
110399 Clinical Sciences not elsewhere classified 40
110999 Neurosciences not elsewhere classified 30
060499 Genetics not elsewhere classified 30

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Membership

Dates Title Organisation / Department
Member - The Myelin Project The Myelin Project
Australia
Member - Human Genetics Society of Australia National Conference Local Organising Committee Human Genetics Society of Australia National Conference Local Organising Committee
Australia
Elected Member - University of Newcastle Academic Senate University of Newcastle
Australia

Awards

Recipient

Year Award
1995 Extraordinary Ability Alien O1 Visa award
Unknown
1992 International Fogarty Fellowship
Unknown

Invitations

PhD Examiner

Year Title / Rationale
2007 PhD Thesis Roula Papadopoulos 1999
Organisation: University of Melbourne
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (3 outputs)

Year Citation Altmetrics Link
2012 Milward AE, Acikyol B, Bassett BL, Williams EJ, Graham R, Delima R, et al., 'Brain changes in iron loading disorders', Metal Ions in Neurological Systems, Springer-Verlag Wien, Heidelberg 17-29 (2012) [B1]
2005 Milward AE, Roy TK, 'Genetic Regulation of the Matrix Metalloproteinases and Related Proteins', Matriz Metalloproteinases in the Central Nervous System, Imperial College Press, London, United Kingdom 19-66 (2005) [B1]
2005 Parsons CH, Koolwijk I, Roy TK, Roy CA, Johnstone DM, Vos CMP, et al., 'Matrix Metalloproteinases and Related Proteins in Alzheimer's Disease, Parkinson's Disease and Other Neurodegenerative Disorders', Matrix Metalloproteinases in the Central Nervous System, Imperial College Press, London, United Kingdom 279-310 (2005) [B1]

Journal article (68 outputs)

Year Citation Altmetrics Link
2016 Heidari M, Johnstone D, Bassett B, Horn R, Martin K, Huff D, et al., 'BRAIN IRON LOCALIZES TO MYELIN AND AFFECTS EXPRESSION OF GENES RELATED TO MYELIN AND NEURODEGENERATION WITH BRAIN IRON ACCUMULATION DISORDERS IN MICE WITH DISRUPTION OF HFE AND TFR2', AMERICAN JOURNAL OF HEMATOLOGY, 91 E100-E100 (2016)
2016 Martin K, Johnstone D, Graham R, van Helden D, Kerr K, Hollins S, et al., 'ALTERATIONS IN CARDIAC IRON STATUS, ELECTROPHYSIOLOGICAL RESPONSES AND TRANSCRIPT LEVELS IN MOUSE MODELS OF DIETARY AND GENETIC IRON LOADING', AMERICAN JOURNAL OF HEMATOLOGY, 91 E160-E160 (2016)
Co-authors Derek Laver, Dirk Vanhelden
2016 Shahandeh A, Johnston D, Brandli A, Milward L, 'RETINAL IRON LOADING AND ABNORMAL VISUAL FUNCTION IN A MOUSE MODEL OF HEMOCHROMATOSIS', AMERICAN JOURNAL OF HEMATOLOGY, 91 E264-E264 (2016)
2016 Bettencourt C, Forabosco P, Wiethoff S, Heidari M, Johnstone DM, Botía JA, et al., 'Gene co-expression networks shed light into diseases of brain iron accumulation', Neurobiology of Disease, 87 59-68 (2016)

© 2015 The Authors. Aberrant brain iron deposition is observed in both common and rare neurodegenerative disorders, including those categorized as Neurodegeneration with Brain Ir... [more]

© 2015 The Authors. Aberrant brain iron deposition is observed in both common and rare neurodegenerative disorders, including those categorized as Neurodegeneration with Brain Iron Accumulation (NBIA), which are characterized by focal iron accumulation in the basal ganglia. Two NBIA genes are directly involved in iron metabolism, but whether other NBIA-related genes also regulate iron homeostasis in the human brain, and whether aberrant iron deposition contributes to neurodegenerative processes remains largely unknown. This study aims to expand our understanding of these iron overload diseases and identify relationships between known NBIA genes and their main interacting partners by using a systems biology approach.We used whole-transcriptome gene expression data from human brain samples originating from 101 neuropathologically normal individuals (10 brain regions) to generate weighted gene co-expression networks and cluster the 10 known NBIA genes in an unsupervised manner. We investigated NBIA-enriched networks for relevant cell types and pathways, and whether they are disrupted by iron loading in NBIA diseased tissue and in an in vivo mouse model.We identified two basal ganglia gene co-expression modules significantly enriched for NBIA genes, which resemble neuronal and oligodendrocytic signatures. These NBIA gene networks are enriched for iron-related genes, and implicate synapse and lipid metabolism related pathways. Our data also indicates that these networks are disrupted by excessive brain iron loading.We identified multiple cell types in the origin of NBIA disorders. We also found unforeseen links between NBIA networks and iron-related processes, and demonstrate convergent pathways connecting NBIAs and phenotypically overlapping diseases. Our results are of further relevance for these diseases by providing candidates for new causative genes and possible points for therapeutic intervention.

DOI 10.1016/j.nbd.2015.12.004
2016 Heidari M, Johnstone DM, Bassett B, Graham RM, Chua ACG, House MJ, et al., 'Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features', Molecular Psychiatry, (2016)

© 2016 Macmillan Publishers Limited The ¿neurodegeneration with brain iron accumulation¿ (NBIA) disease family entails movement or cognitive impairment, often with psychiatric ... [more]

© 2016 Macmillan Publishers Limited The ¿neurodegeneration with brain iron accumulation¿ (NBIA) disease family entails movement or cognitive impairment, often with psychiatric features. To understand how iron loading affects the brain, we studied mice with disruption of two iron regulatory genes, hemochromatosis (Hfe) and transferrin receptor 2 (Tfr2). Inductively coupled plasma atomic emission spectroscopy demonstrated increased iron in the Hfe-/- × Tfr2mut brain (P=0.002, n =5/group), primarily localized by Perls¿ staining to myelinated structures. Western immunoblotting showed increases of the iron storage protein ferritin light polypeptide and microarray and real-time reverse transcription-PCR revealed decreased transcript levels (P<0.04, n =5/group) for five other NBIA genes, phospholipase A2 group VI, fatty acid 2-hydroxylase, ceruloplasmin, chromosome 19 open reading frame 12 and ATPase type 13A2. Apart from the ferroxidase ceruloplasmin, all are involved in myelin homeostasis; 16 other myelin-related genes also showed reduced expression (P<0.05), although gross myelin structure and integrity appear unaffected (P>0.05). Overlap (P<0.0001) of differentially expressed genes in Hfe-/- × Tfr2mut brain with human gene co-expression networks suggests iron loading influences expression of NBIA-related and myelin-related genes co-expressed in normal human basal ganglia. There was overlap (P<0.0001) of genes differentially expressed in Hfe-/- × Tfr2mut brain and post-mortem NBIA basal ganglia. Hfe-/- × Tfr2mut mice were hyperactive (P<0.0112) without apparent cognitive impairment by IntelliCage testing (P>0.05). These results implicate myelin-related systems involved in NBIA neuropathogenesis in early responses to iron loading. This may contribute to behavioral symptoms in NBIA and hemochromatosis and is relevant to patients with abnormal iron status and psychiatric disorders involving myelin abnormalities or resistant to conventional treatments.Molecular Psychiatry advance online publication, 5 January 2016; doi:10.1038/mp.2015.192.

DOI 10.1038/mp.2015.192
2015 Daneshi N, Graham ME, Milward ADRIENNEELIZABETHLIZ, 'An update on warfarin pharmacogenomics Part 1 of 2', Australian Pharmacist, 34 52-56 (2015) [C2]
2015 Graham ME, Milward ADRIENNEELIZABETHLIZ, 'Pharmacogenomics, personalised healthcare and herbal medicine - a paradoxical combination?', Australian Pharmacist, (2015) [C3]
2015 Daneshi N, Graham ME, Biswas M, Milward AE, 'Gene Scene - Health's New Frontier', Australian Pharmacist, (2015) [C2]
2014 Graham M, Milward AE, 'The future of personalised healthcare in pharmacy practice', Australian Pharmacist, (2014)
2014 Milward EA, Moscato P, Riveros C, Johnstone DM, 'Beyond Statistics: A New Combinatorial Approach to Identifying Biomarker Panels for the Early Detection and Diagnosis of Alzheimer's Disease', JOURNAL OF ALZHEIMERS DISEASE, 39 211-217 (2014) [C1]
DOI 10.3233/JAD-131424
Citations Scopus - 1Web of Science - 1
Co-authors Pablo Moscato, Carlos Riveros
2014 Mate K, Riveros C, Weidenhofer J, Goldie B, Scott J, Moscato P, et al., 'Strategies for Enhancing Communication between Students, Academics and Researchers participating in Large-Scale Undergraduate Research Projects', International Journal of Innovation in Science and Mathematics Education, 22 14-29 (2014) [C1]
Co-authors Judith Weidenhofer, Carlos Riveros, Karen Mate, Pablo Moscato
2013 Acikyol B, Graham RM, Trinder D, House MJ, Olynyk JK, Scott RJ, et al., 'Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation', Neuroscience, 235 119-128 (2013) [C1]
DOI 10.1016/j.neuroscience.2013.01.014
Citations Scopus - 4Web of Science - 2
Co-authors Rodney Scott
2013 Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
DOI 10.1002/bmb.20672
Citations Scopus - 1
Co-authors Alistair Sim, Karen Mate, Judith Weidenhofer
2013 Johnstone DM, Riveros C, Heidari M, Graham RM, Trinder D, Berretta R, et al., 'Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes', Microarrays, 2 131-152 (2013) [C1]
Co-authors Rodney Scott, Pablo Moscato, Carlos Riveros, Regina Berretta
2012 Chalmers KA, Knuiman MW, Divitini ML, Bruce DG, Olynyk JK, Milward AE, 'Long-term mortality risks associated with mild anaemia in older persons: The Busselton health study', Age and Ageing, 41 759-764 (2012) [C1]
Citations Scopus - 4Web of Science - 2
Co-authors Kerry Chalmers
2012 Delima RD, Riveros RC, Olynyk JK, Scott R, Moscato PA, Milward AE, et al., 'Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading', Brain Research, 1448 144-152 (2012) [C1]
Citations Scopus - 9Web of Science - 7
Co-authors Rodney Scott, Carlos Riveros, Pablo Moscato
2012 Milward AE, Daneshi N, Johnstone DM, 'Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery', Pharmacology and Therapeutics, 136 295-304 (2012) [C1]
DOI 10.1016/j.pharmthera.2012.08.008
Citations Scopus - 5Web of Science - 1
2012 Johnstone DM, Graham RM, Trinder D, Riveros RC, Olynyk JK, Scott R, et al., 'Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk', Journal of Alzheimers Disease, 30 791-803 (2012) [C1]
Citations Scopus - 4Web of Science - 3
Co-authors Pablo Moscato, Carlos Riveros, Rodney Scott
2012 Johnstone DM, Milward AE, Berretta RE, Moscato PA, 'Multivariate protein signatures of pre-clinical Alzheimer's disease in the Alzheimer's disease meuroimaging initiative (ADNI) plasma proteome dataset', PLoS One, 7 e34341 (2012) [C1]
Citations Scopus - 30Web of Science - 19
Co-authors Pablo Moscato, Regina Berretta
2011 Zhou J, Broe M, Huang Y, Anderson JP, Gai W-P, Milward AE, et al., 'Changes in the solubility and phosphorylation of alpha-synuclein over the course of Parkinson's disease', Acta Neuropathologica, 121 695-704 (2011) [C1]
DOI 10.1007/s00401-011-0815-1
Citations Scopus - 30Web of Science - 26
2010 Johnstone DM, Milward AE, 'Molecular genetic approaches to understanding the roles and regulation of iron in brain health and disease', Journal of Neurochemistry, 113 1387-1402 (2010) [C1]
DOI 10.1111/j.1471-4159.2010.06697.x
Citations Scopus - 20Web of Science - 16
2010 Johnstone DM, Milward AE, 'Genome-wide microarray analysis of brain gene expression in mice on a short-term high iron diet', Neurochemistry International, 56 856-863 (2010) [C1]
DOI 10.1016/j.neuint.2010.03.015
Citations Scopus - 14Web of Science - 13
2010 Graham RM, Chua ACG, Carter KW, Delima RD, Johnstone DM, Herbison CE, et al., 'Hepatic iron loading in mice increases cholesterol biosynthesis', Hepatology, 52 462-471 (2010) [C1]
DOI 10.1002/hep.23712
Citations Scopus - 26Web of Science - 20
2010 Yeap BB, Beilin J, Shi Z, Knuiman MW, Olynyk JK, Chubb SAP, et al., 'The C282Y polymorphism of the hereditary hemochromatosis gene is associated with increased sex hormone-binding globulin and normal testosterone levels in men', Journal of Endocrinological Investigation, 33 544-548 (2010) [C1]
DOI 10.3275/6864
Citations Scopus - 1
2010 House MJ, Pierre TGS, Milward AE, Bruce DG, Olynyk JK, 'Relationship Between Brain R-2 and Liver and Serum Iron Concentrations in Elderly Men', Magnetic Resonance in Medicine, 63 275-281 (2010) [C1]
DOI 10.1002/mrm.22263
Citations Scopus - 18Web of Science - 16
2010 Milward AE, Bruce DG, Knuiman MW, Divitini ML, Cole M, Inderjeeth CA, et al., 'A cross-sectional community study of serum iron measures and cognitive status in older adults', Journal of Alzheimers Disease, 20 617-623 (2010) [C1]
DOI 10.3233/JAD-2010-1402
Citations Scopus - 9Web of Science - 8
2009 Shi Z, Johnstone DM, Talseth-Palmer B, Evans T-J, Spigelman AD, Groombridge C, et al., 'Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age', International Journal of Cancer, 125 78-83 (2009) [C1]
DOI 10.1002/ijc.24304
Co-authors Rodney Scott, Bente Talseth-Palmer
2009 Yeap BB, Beilin J, Shi Z, Knuiman MW, Olynyk JK, Bruce DG, Milward AE, 'Serum testosterone levels correlate with haemoglobin in middle-aged and older men', Internal Medicine Journal, 39 532-538 (2009) [C1]
DOI 10.1111/j.1445-5994.2008.01789.x
Citations Scopus - 15Web of Science - 12
2008 Ayonrinde OT, Milward AE, Chua ACG, Trinder D, Olynyk JK, 'Clinical perspectives on hereditary hemochromatosis', Critical Reviews in Clinical Laboratory Sciences, 45 451-484 (2008) [C1]
DOI 10.1080/10408360802335716
Citations Scopus - 19Web of Science - 15
2008 Milward AE, Baines SK, Knijiman MW, Bartholomew HC, Divitini ML, Ravine DG, et al., 'Noncitrus fruits as novel dietary environmental modifiers of iron stores in people with or without HFE gene mutations', Mayo Clinic Proceedings, 83 543-549 (2008) [C1]
DOI 10.4065/83.5.543
Citations Scopus - 25Web of Science - 23
Co-authors Surinder Baines
2008 Milward AE, Kim KJ, Szklarczyk A, Nguyen T, Melli G, Nayak M, et al., 'Cleavage of myelin associated glycoprotein by matrix metalloproteinases', Journal of Neuroimmunology, 193 140-148 (2008) [C1]
DOI 10.1016/j.jneuroim.2007.11.001
Citations Scopus - 28Web of Science - 25
2007 Szklarczyk A, Stins M, Milward AE, Ryu H, Fitzsimmons C, Sullivan D, Conant K, 'Glial activation and matrix metalloproteinase release in cerebral malaria', Journal of Neurovirology, 13 2-10 (2007) [C1]
DOI 10.1080/13550280701258084
Citations Web of Science - 16
2007 Milward AE, Fitzsimmons C, Szklarczyk A, Conant K, 'The matrix metalloproteinases and CNS plasticity: An overview', Journal of Neuroimmunology, 187 9-19 (2007) [C1]
DOI 10.1016/j.jneuroim.2007.04.010
Citations Scopus - 41Web of Science - 36
2007 Milward AE, Johnstone DM, Trinder D, Ramm G, Olynyk J, 'The Nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT', Hepatology, 45 253-256 (2007) [C1]
DOI 10.1002/hep.21526
Citations Scopus - 11
2005 Olynyk JK, Trinder D, Milward AE, 'Hereditary haemochromatosis: To screen or not to screen? (editorial)', Journal of Hepatology, 43 9-10 (2005) [C3]
Citations Scopus - 5Web of Science - 5
2005 Kairupan CF, Meldrum CJ, Crooks R, Milward EA, Spigelman AD, Burgess B, et al., 'Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations', International Journal of Cancer, 116 73-77 (2005) [C1]
DOI 10.1002/ijc.20983
Citations Scopus - 30Web of Science - 24
Co-authors Rodney Scott
2005 Broe M, Shepherd CE, Mann DMA, Milward AE, Gai W-P, Thiel E, Halliday GM, 'Insoluble alpha-Synuclein in Alzheimer's Disease without Lewy Body Formation', Neurotoxicity Research, 7 69-76 (2005) [C1]
DOI 10.1007/BF03033777
Citations Web of Science - 9
2005 Milward AE, Trinder D, Wilcox C, Britton RS, Ramm GA, Olynyk JK, 'Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease?', Hepatology, 41 936-938 (2005) [C1]
DOI 10.1002/hep.20652
Citations Scopus - 4
2004 Verdile G, Gnjec A, Miklossy J, Fonte J, Veurink G, Bates K, et al., 'Protein markers for Alzheimer disease in the frontal cortex and cerebellum', Neurology, 63 1385-1392 (2004) [C1]
DOI 10.1212/01.WNL.0000141848.45315.A6
Citations Scopus - 17Web of Science - 14
2004 Milward EA, 'Student input into gene patent law reform', Issues 2004, 67 27-30 (2004) [C2]
2002 Conant K, Haughey N, Nath A, St Hillaire C, Gary DS, Pardo CA, et al., 'Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9', Journal of Neurochemistry, 82 885-893 (2002) [C1]
Citations Web of Science - 22
2001 Broe M, Shepherd CE, Milward EA, Halliday GM, 'Relationship between DNA fragmentation, morphological changes and neuronal loss in Alzheimer''s disease and dementia with Lewy bodies', Acta Neuropathologica, 101 616-624 (2001) [C1]
2001 Connor JR, Milward EA, Moalem S, Sampietro M, Boyer P, Percy ME, et al., 'Is hemochromatosis a risk factor for Alzheimer''s disease?', Journal of Alzheimer''s Disease, 3 471-477 (2001) [C1]
Citations Scopus - 60
Co-authors Rodney Scott
2000 Milward E, Grayson D, Creasey H, Kyngdon B, Janu M, Brooks W, Broe GA, 'Clinical issues - Anaemia and dementia in community-dwelling Australian elderly', AUSTRALASIAN JOURNAL ON AGEING, 19 25-25 (2000)
2000 Milward E, Zhang SC, Zhao M, Lundberg C, Ge B, Goetz BD, Duncan ID, 'Enhanced proliferation and directed migration of oligodendroglial progenitors co-grafted with growth factor secreting cells', Glia, 32 264-270 (2000) [C1]
Citations Scopus - 19Web of Science - 17
2000 Milward E, Grayson D, Creasey H, Kyngdon B, Janu M, Brooks W, Broe GA, 'Anaemia and dementia in community-dwelling Australian elderly', Australasian Journal of Ageing, 19 (2000) [C2]
2000 Broe M, Shepherd CE, Milward EA, Halliday GM, 'Morphological features of DNA fragmentation in patients with movement disorders and dementia', European Journal of Neuroscience, 12 (2000) [C2]
1999 Milward EA, Grayson DA, Creasey H, Janu MR, Brooks WS, Broe GA, 'Evidence for association of anaemia with vascular dementia', Neuroreport, 10 2377-2381 (1999) [C1]
Citations Scopus - 29Web of Science - 21
1999 Kwok JBJ, Li Q-X, Hallupp M, Milward L, Whyte S, Schofield PR, 'Novel familial early-onset Alzheimer''s disease mutation (Leu723Pro) in amyloid precursor protein (APP) gene increases production of 42(43) amino acid isoform of amyloid-beta peptide.', Alzheimer''s Disease and Related Disorders, 69-79 (1999) [C1]
1997 Milward EA, Lundberg CG, Ge B, Lipsitz D, Zhao M, Duncan ID, 'Isolation and transplantation of multipotential populations of epidermal growth factor responsive neural progenitor cells from the canine brain', Journal of Neuroscience Research, 50 862-871 (1997) [C1]
Citations Scopus - 58Web of Science - 55
1997 Fannarraga M, Milward EA, 'Characterization of a putative novel type of oligodendrocyte in cultures from rat spinal cord.', European Journal of Neuroscience, 9 2213-2217 (1997) [C1]
Citations Web of Science - 6
1996 Zhao M, Milward EA, Duncan ID, 'Migration and myelination by CG4 cells in brain after intraventricular transplant', Journal of Neurochemistry, 66 (1996) [C2]
1996 Milward EA, Lundberg CG, Ge B, Lipsitz D, Duncan ID, 'EGF-responsive multipotential neural progenitor cells from normal and ''shaking'' pups.', Journal of Neurochemistry, 66 (1996) [C2]
1995 Wilt SG, Milward E, Zhou JM, Nagasato K, Patton H, Rusten R, et al., 'In vitro evidence for a dual role of tumor necrosis factor-alpha in human immunodeficiency virus type 1 encephalopathy', Annals of Neurology, 37 381-394 (1995) [C1]
Citations Scopus - 128Web of Science - 141
1995 Duncan ID, Milward EA, 'Glial cell transplants: experimental therapies of myelin diseases', Brain Pathology, 5 301-310 (1995) [C1]
Citations Scopus - 34Web of Science - 32
1994 Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O''Connor M, et al., 'Plasticity in the adult human oligodendrocyte lineage', Journal of Neuroscience, 14 4571-4587 (1994) [C1]
Citations Scopus - 91Web of Science - 94
1993 Milward EA, Dottori M, Papadopoulos R, Moir RD, Fuller SJ, Beyreuther K, Masters CL, 'Neurotrophic and cytotoxic actions of amyloid protein precursor of Alzheimer''s disease.', Advances in the Biosciences, 87 349-350 (1993) [C2]
1992 Moir RD, Martins RN, Bush AI, Small DH, Milward EA, Rumble BA, et al., 'Human brain beta A4 amyloid protein precursor of Alzheimer''s disease: purification and partial characterization', Journal of Neurochemistry, (1992) [C1]
Citations Scopus - 37Web of Science - 46
1992 Milward EA, Papadopoulos R, Fuller SJ, Moir RD, Small D, Beyreuther K, Masters CL, 'The amyloid protein precursor of Alzheimer''s disease is a mediator of the effects of nerve growth factor on neurite outgrowth.', Neuron, 9 129-137 (1992) [C1]
Citations Scopus - 335Web of Science - 373
1992 Milward EA, Dottori M, Papadopoulos R, Moir RD, Fuller SJ, Beyreuther K, Masters CL, 'Beta A4 amyloid protein precursor of Alzheimer''s disease: evidence for neurotrophic and cytotoxic actions.', Neurobiology of Aging, 13 (1992) [C2]
1991 Small DH, Moir RD, Fuller SJ, Michaelson S, Bush AI, Li QX, et al., 'A protease activity associated with acetylcholinesterase releases the membrane-bound form of the amyloid protein precursor of Alzheimer''s disease', Biochemistry, 30 10795-10799 (1991) [C1]
Citations Scopus - 49Web of Science - 65
1991 Milward EA, Papadopoulos R, Fuller S, Beyreuther K, Masters CL, 'Alzheimer''s disease amyloid precursor protein promotes neurite outgrowth in PC12 cells.', Journal of Neurochemistry, 57 (1991) [C2]
1990 BUSH AI, MARTINS RN, RUMBLE B, MOIR R, FULLER S, MILWARD E, et al., 'THE AMYLOID PRECURSOR PROTEIN OF ALZHEIMERS-DISEASE IS RELEASED BY HUMAN PLATELETS', JOURNAL OF BIOLOGICAL CHEMISTRY, 265 15977-15983 (1990)
Citations Web of Science - 244
1990 Milward EA, Yeoh GC, 'Expression of alpha-fetoprotein by differentiating fetal rat hepatocytes in vitro.', European Journal of Cell Biology, 52 185-192 (1990) [C1]
Citations Scopus - 6Web of Science - 6
1990 MASTERS CL, BUSH A, EVIN G, FULLER S, LI QX, MACKENZIE I, et al., 'THE BA4 AMYLOID PROTEIN AND ITS PRECURSORS AS BIOLOGICAL MARKERS FOR ALZHEIMERS-DISEASE', NEUROBIOLOGY OF AGING, 11 330-331 (1990)
DOI 10.1016/0197-4580(90)90874-Y
1990 Milward E, Martins R, Rumble B, Moir R, Weidemann A, Beyreuther K, Masters CL, 'Expression of Alzheimer''s disease amyloid precursor protein during postnatal development of rat brain.', Neurobiology of Aging, 11 (1990) [C2]
1990 Bush A, Martins R, Rumble B, Moir R, Fuller SJ, Milward E, et al., 'The amyloid precursor protein of Alzheimer''s disease is released by human platelets.', Neurobiology of Aging, 11 (1990) [C2]
Citations Scopus - 189
1989 Cake MH, Ho KK, Shelly L, Milward E, Yeoh GC, 'Insulin antagonism of dexamethasone induction of tyrosine aminotransferase in cultured fetal hepatocytes. A correlation between enzyme activity, synthesis, level of messenger RNA and transcription.', European Journal of Biochemistry, 182 429-435 (1989) [C1]
Citations Web of Science - 20
Show 65 more journal articles

Conference (37 outputs)

Year Citation Altmetrics Link
2016 Biswas M, Daneshi N, Dias T, Rasiah R, Mate K, Holliday E, et al., 'Prevalence of drug and gene interactions for cardiovascular drugs in older Australians' (2016)
Co-authors John Attia, Karen Kerr
2016 Martin K, Johnstone D, Graham R, Van Helden D, Kerr KP, Hollins S, et al., 'Alterations in cardiac iron status, electrophysiological responses and transcript levels in mouse models of dietary and genetic iron loading' (2016)
Co-authors Karen Kerr
2016 Martin K, Johnstone D, Dosen P, Graham R, van Helden D, Kerr KP, et al., 'Assessment of cardiac iron loading and pacemaker activity in two mouse models of genetic haemochromatosis.' (2016)
Co-authors Karen Kerr
2016 Martin K, Johnstone D, Dosen P, Graham R, Van Helden D, Kerr KP, et al., 'Cardiac iron loading and pacemaker activity in two mouse models of genetic haemochromatosis' (2016)
Co-authors Karen Kerr
2016 Martin K, Johnstone D, Dosen P, Graham R, Liu J, Van helden D, et al., 'Increased iron loading in mouse models of genetic haemochromatosis and the assessment of cardiac function' (2016)
Co-authors Karen Kerr
2015 Daneshi N, Graham M, Holliday E, Schneider J, Kerr KP, Rasiah R, et al., 'Clinically actionable pharmacogenomic variants in community-dwelling older Australians.', ASMR XXIII NSW Scientific Meeting: Programme and Abstracts (2015)
Co-authors Karen Kerr, John Attia
2015 Baldwin M, Martin K, Kerr KP, Bower C, Van Helden D, Johnstone D, Milward AE, 'Heart iron accumulation and altered sinoatrial node response in a Tfr2mut mouse model of the iron disorder haemochromatosis' (2015)
Co-authors Karen Kerr
2015 Baldwin M, Kerr KP, Bower C, Van Helden D, Johnstone D, Milward AE, Martin K, 'Altered sinoatrial node response and iron accumulation in the hearts of a Tfr2mut mouse model of the iron overload disorder haemochromatosis.' (2015)
Co-authors Karen Kerr
2015 Martin K, Johnstone D, Graham R, Van Helden D, Kerr KP, Hollins S, et al., 'The effects of iron loading on electrophysiological responses and transcript levels in dietary or genetic mouse models.' (2015)
Co-authors Karen Kerr
2015 Biswas M, Daneshi N, Rasiah R, Mate K, Holliday E, Attia J, et al., 'Prevalence of cytochrome P450 (CYP) substrate-inhibitor interactions in patients on clopidogrel and frequency of CYP2C19*2 gene variants', Australasian Pharmaceutical Science Association (APSA)- Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) Joint Scientific Meeting. Book of Poster Abstracts (2015) [E3]
Co-authors John Attia, Karen Kerr, Karen Mate, Liz Holliday, Rohan Rasiah
2013 Milward E, Heidari M, Acikyol B, Graham R, Chua A, Delima R, et al., 'IRON ACCUMULATION IN THE CHOROID PLEXUS AND OTHER BRAIN BARRIER COMPONENTS IN MOUSE MODELS OF HEMOCHROMATOSIS', AMERICAN JOURNAL OF HEMATOLOGY (2013) [E3]
Co-authors Pablo Moscato
2013 Heidari M, Johnstone D, Graham R, Martin K, Olynyk J, Trinder D, et al., 'DOES IRON HAVE CAUSAL ROLES IN NEURODEGENERATION WITH BRAIN IRON ACCUMULATION? - A NEW VIEW FROM A MOUSE MODEL OF HEMOCHROMATOSIS', AMERICAN JOURNAL OF HEMATOLOGY (2013) [E3]
2013 Graham R, Delima RD, Johnstone D, Milward EA, Olynyk JK, Trinder D, 'CHANGES IN GENE EXPRESSION OF CHOLESTEROL METABOLISM PATHWAYS IN MOUSE MODELS OF HAEMOCHROMATOSIS', AMERICAN JOURNAL OF HEMATOLOGY (2013) [E3]
2011 Johnstone DM, Acikyol B, Graham R, House M, Trinder D, Olynyk J, et al., 'Gene expression studies in four different mouse models support the case for brain perturbations in iron overload disorders', Program Book: Fourth Congress of the International BioIron Society (IBIS) (2011) [E3]
Co-authors Pablo Moscato
2011 Acikyol B, Johnstone DM, Trinder D, Cairns MJ, Milward AE, 'Gene expression changes relating to key brain functions and neuropsychiatric disorders in the TFR2 mutant mouse', Program Book: Fourth Congress of the International BioIron Society (IBIS) (2011) [E3]
Co-authors Murray Cairns
2011 Milward AE, Hollins SL, Graham R, Trinder D, Van Balen M, Olynyk J, et al., 'Iron and the biogenesis of melanin and melanosomes in the retina', Program Book: Fourth Congress of the International BioIron Society (IBIS) (2011) [E3]
Co-authors Murray Cairns
2011 Johnstone DM, Zandvakili S, Graham R, Trinder D, Scott R, Olynyk J, et al., 'Molecular changes relevant to motor neuron disease in the HFE-/- mouse model of hemochromatosis', Program Book: Fourth Congress of the International BioIron Society (IBIS) (2011) [E3]
Co-authors Pablo Moscato, Rodney Scott
2011 Graham RM, Chua ACG, Delima RD, Johnstone DM, Milward AE, Olynyk JK, Trinder D, 'Upregulation of genes involved in cholesterol sorting in the face of hepatic iron loading', Program Book: Fourth Congress of the International BioIron Society (IBIS) (2011) [E3]
2010 Milward, Ravetti M, Rosso O, Berretta RE, Johnstone D, Moscato P, 'A new approach to tracking progression of molecular pathogenesis in Alzheimer¿s disease identifies hippocampla iron dyshomeostasis as a novel potential biomarker' (2010)
Co-authors Pablo Moscato, Regina Berretta
2009 Graham RM, Chua ACG, Carter K, Delima RD, Johnstone DM, Herbison CE, et al., 'Alterations in iron status are associated with changes in the cholesterol biosynthesis pathway', 2009 International Biolron Society Meeting: Program Book (2009) [E3]
2009 Hollins SL, Johnstone DM, Graham R, Van Helden DF, Kerr KP, Laver DR, et al., 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book (2009) [E3]
Co-authors Rodney Scott, Derek Laver, Dirk Vanhelden, Karen Kerr
2009 House M, St Pierre T, Milward AE, Bruce D, Olynyk J, 'Relationship between brain R2 and liver and serum iron concentrations in elderly men', 2009 International Biolron Society Meeting: Program Book (2009) [E3]
DOI 10.1002/mrm.22263
2009 Johnstone DM, Graham R, Trinder D, Scott R, Olynyk J, Milward AE, 'Gene expression changes related to Alzheimer's disease and other neurodegenerative disorders in a hemochromatosis Hfe knockout mouse model', 2009 International Biolron Society Meeting: Program Book (2009) [E3]
Co-authors Rodney Scott
2009 Johnstone DM, Graham RM, Trinder D, Scott R, Olynyk J, Milward AE, 'Genome-wide microarray analysis of brain from a hemochromatosis Hfe knockout mouse model shows few changes in iron-related gene expression', 2009 International Biolron Society Meeting: Program Book (2009) [E3]
Co-authors Rodney Scott
2009 Johnstone DM, Ravetti MG, Riveros C, Moscato PA, Hersey P, Scott R, Milward AE, 'Genome-wide microarray analysis of melanoma reveals unexpected anomalies in iron-related gene expression', 2009 International Biolron Society Meeting: Program Book (2009) [E3]
Co-authors Rodney Scott, Pablo Moscato, Carlos Riveros
2009 Milward AE, Bruce D, Cole M, Knuiman M, Divitini M, Bartholomew H, et al., 'Serum ferritin is not related to cognitive status: Results from a perspective community study of older Australians', 2009 International Biolron Society Meeting: Program Book (2009) [E3]
2009 Johnstone DM, Graham RM, Trinder D, Scott R, Olynyk J, Milward AE, 'Genome-wide brain gene expression changes related to Alzheimer's disease and other neurodegenerative disorders in mouse models of dietary iron overload and human haemochromatosis', ASMR National Scientific Conference 2009. Proceedings of The Australian Society for Medical Research, 48th National Scientific Conference (2009) [E3]
Co-authors Rodney Scott
2009 Fitzsimmons C, Johnstone DM, Conant K, Milward AE, 'Matrix metalloproteinase (MMP) - mediated cleavage of the low-density lipoprotein receptor-related protein (LRP)', ASMR XVII NSW Scientific Meeting: Programme and Abstracts (2009) [E3]
2009 Hollins SL, Johnstone DM, Van Helden DF, Kerr KP, Laver DR, Metelerkamp KM, et al., 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts (2009) [E3]
Co-authors Rodney Scott, Karen Kerr, Dirk Vanhelden, Derek Laver
2009 Johnstone DM, Ravetti MG, Moscato PA, Hersey P, Scott R, Milward AE, 'Metabolic gene expression in advanced melanoma', ASMR XVII NSW Scientific Meeting: Programme and Abstracts (2009) [E3]
Co-authors Pablo Moscato, Rodney Scott
2009 Goldie BJ, Johnstone DM, Milward AE, 'Evaluation of bioinformatics tools for ontology analysis', ASMR XVII NSW Scientific Meeting: Programme and Abstracts (2009) [E3]
2009 Graham RM, Chua ACG, Carter K, Delima RD, Johnstone DM, Herbison CE, et al., 'Alterations in iron status are associated with changes in the cholesterol biosynthesis pathway', Proceedings of the 19th Annual Combined Biological Sciences Meeting: Programme and Abstracts (2009) [E3]
2009 Milward AE, Johnstone DM, Ravetti MG, Berretta RE, Hersey P, Scott R, Moscato PA, 'The relationship between Parkinson's disease and melanoma: Insights from microarray analysis of genome-wide gene expression changes in melanoma', ASMR National Scientific Conference 2009. Proceedings of The Australian Society for Medical Research, 48th National Scientific Conference (2009) [E3]
Co-authors Regina Berretta, Rodney Scott, Pablo Moscato
2008 Milward AE, Bruce D, Cole M, Kniuman M, Divitini M, Bartholomew H, et al., 'No relationship between serum ferritin and cognitive status in a prospective community study of older adults', Alzheimer's and Dementia (2008) [E3]
2008 Fitzsimmons C, Johnstone DM, Conant K, Milward AE, 'Matrix metalloproteina-mediated cleavage of the low-density lipoprotein receptor-related protein to generate soluble species with neurodegenerative potential', Alzheimer's and Disease (2008) [E3]
2008 Johnstone DM, Graham R, Trinder D, Scott R, Olynyk JK, Milward AE, 'Alterations in the expression of genes important in Alzheimer's disease (APP presenilin 1 tau) in the HFE knockout mouse model of the iron disorder hemochromatosis', Alzheimer's and Disease (2008) [E3]
Co-authors Rodney Scott
2008 Johnstone DM, Riveros C, Moscato P, Milward EA, 'Effects of different normalisation and analysis procedures on illumina gene expression microarray data' (2008)
Co-authors Carlos Riveros, Pablo Moscato
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Grants and Funding

Summary

Number of grants 21
Total funding $1,748,906

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $20,000

Investigation of the progression of Alzheimers Disease: Identification of potential drivers of disease$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Associate Professor Liz Milward, Professor Phil Hansbro, Dr Daniel Johnstone
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500589
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20142 grants / $95,240

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

Miltenyi Biotec GentleMACS Octo Dissociator with Heaters $23,566

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Darryl Knight, Professor Dirk Van Helden, Professor Joerg Mattes, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Associate Professor Liz Milward, Dr NATHAN Bartlett, Doctor Simon Keely, Doctor Steven Maltby, Doctor Andrew Jarnicki, Doctor Malcolm Starkey, Doctor Adam Collison, Ms Shaan Gellatly
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500861
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20132 grants / $59,596

20121 grants / $1,500

Molecular and Functional Responses to Iron Dysregulation in the Heart$1,500

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Bassett, Brianna, Associate Professor Liz Milward
Scheme Summer Scholarship
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1201015
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20111 grants / $10,000

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Associate Professor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Bristow, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Dr DAN Johnstone, Ms BELINDA Goldie, Doctor Natalie Beveridge
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100030
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20102 grants / $101,115

HMRI MRSP Infrastructure Grant (10-11) - Cardiovascular$76,117

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Eugene Nalivaiko, Associate Professor Liz Milward, Professor Robert Callister, Professor Manohar Garg, Conjoint Professor Tony Quail
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1100525
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Identification of novel biomarkers for pre-clinical Alzheimer's disease$24,998

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Pablo Moscato, Associate Professor Liz Milward, Doctor Martin Ravetti, Dr DAN Johnstone, Dr M Guillemin, Associate Professor Regina Berretta
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900149
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20083 grants / $29,000

The effects of iron status on calcium handling systems in heart and brain$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Derek Laver, Associate Professor Liz Milward, Professor Dirk Van Helden, Professor Rodney Scott
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188463
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

International Conference on Alzheimer's Disease ICAD 2008, Chicago, 26/7/2008 - 31/7/2008$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Liz Milward
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189220
Type Of Funding Internal
Category INTE
UON Y

Changes in heart gene expression in mice with a genetic iron disorder$1,500

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Associate Professor Liz Milward
Scheme Summer Scholarship
Role Lead
Funding Start 2008
Funding Finish 2009
GNo G0189532
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20073 grants / $46,414

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Associate Professor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188196
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

2007 Research Development Fellowship$8,224

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Liz Milward
Scheme Research Development Fellowship
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188237
Type Of Funding Internal
Category INTE
UON Y

Microarray analyses of genes important in iron regulation and related disorders$8,190

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Liz Milward, Professor Rodney Scott
Scheme Pilot Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187902
Type Of Funding Internal
Category INTE
UON Y

20063 grants / $1,184,915

PRC - Priority Research Centre for Gender health & Ageing$543,772

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Julie Byles, Professor Sandra Capra, Associate Professor Pauline Chiarelli, Conjoint Professor David Henry, Professor Tina Koch, Ms Chris Landorf, Conjoint Professor Chris Levi, Associate Professor Deb Loxton, Associate Professor Liz Milward, Conjoint Associate Professor Lynne Parkinson, Professor Dimity Pond, Conjoint Professor David Sibbritt, Associate Professor Anne Young
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2013
GNo G0186949
Type Of Funding Internal
Category INTE
UON Y

Anaemia in older Australians$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Liz Milward, Professor John Olynyk, Associate Professor Matthew Knuiman, Associate Professor David Bruce, Professor Joseph Hung, Professor Paola Ferrari
Scheme Near Miss Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186060
Type Of Funding Internal
Category INTE
UON Y

20051 grants / $29,326

Scholarship - Matching - Semester 2, 2005$29,326

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Liz Milward
Scheme Multi-Year Project Grant Scholarship
Role Lead
Funding Start 2005
Funding Finish 2008
GNo G0185744
Type Of Funding Internal
Category INTE
UON Y

20041 grants / $15,000

Effects of relaxation training in anxiety levels in patients with Alzheimers$15,000

Funding body: Alzheimers Australia Dementia Research Foundation Limited

Funding body Alzheimers Australia Dementia Research Foundation Limited
Project Team Ms Cherie Roy, Associate Professor Liz Milward
Scheme Dementia Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183983
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20031 grants / $156,800

Iron and cognition in older adults$156,800

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Liz Milward
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2005
GNo G0182748
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y
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Research Supervision

Number of supervisions

Completed6
Current8

Total current UON EFTSL

PhD4.5

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2016 PhD The Effects of Iron Deficiency on the Hearts of Mouse Models of Haemochromatosis
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2015 PhD Neuropathological Effects of Putative Modifiers of Alzheimer's Disease Risk and Progression: Investigation in Mouse Models
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Effect of Iron loading on vision in a mouse model of haemochromatosis
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Investigating the inter-relationship between iron, infection and immunity in the pathogenesis of lung disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Assessment of Potential Drug and Gene Interactions from High-Throughput Genotyping Data in a Community Cohort of Older Australians
PhD (Pharmacy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Genomic Factors Influencing Individual Disease or Drug Responses in Rheumatoid Arthritis
PhD (Pharmacy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Do Iron Abnormalities Exacerbate Alzheimers Disease? Investigations in Novel Mouse Models
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD The Feasibility and Value of Holistic Systems-Based Approaches to Personalised, Patient-Centred Healthcare in Modern Pharmacy
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2016 PhD Cellular and Molecular Changes in Brain of the Hfe-/-xTfr2mut Mouse, A Model of Human Iron Loading
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 Masters Gene Expression in the Brain of Mutant Mouse Models of Human Iron Overload
M Philosophy (Medical Genetic), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD Cleavage of the Low-Density Lipoprotein-Receptor-Related Protein (LRP) by Matrix Metalloproteinases (MMPs) in a Neural Cell Model: Identification of Multiple Soluble LRP (sLRP) Cleavage Products
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
2012 PhD Matrix Metalloproteinase-2 in Early Embryo Implantation in the Mouse
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2011 PhD Microarray Studies of Genome-Wide Changes in Brain and Heart Gene Expression in Mouse Models of Iron Overload
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2009 PhD Genetic Variations in the Base Excision Repair Gene Mutyh and its Relationship with Two Common Malignancies
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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Associate Professor Liz Milward

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Genetics

Contact Details

Email liz.milward@newcastle.edu.au
Phone (02) 4921 5167
Fax (02) 4921 7903

Office

Room MS408
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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