| 2025 |
McKenzie BL, Cavenagh D, Collins C, Harris K, Woodward M, 'Diet Quality Indices, All-Cause Mortality, Cardiovascular Disease, and Dementia—Outcomes from the Australian Longitudinal Study on Women's Health', Journal of Nutrition, 155, 1508-1519 (2025) [C1]
Background: Cardiovascular disease (CVD) and dementia are the leading causes of death for Australian women. Diet is a modifiable risk factor; however, extent of risk re... [more]
Background: Cardiovascular disease (CVD) and dementia are the leading causes of death for Australian women. Diet is a modifiable risk factor; however, extent of risk reduction by type of diet is unclear. Objectives: This study aimed to evaluate the relationship between indices of diet quality: Australian Recommended Food Score (ARFS), Mediterranean diet food score (MDFS), and cluster analysis, with all-cause mortality, CVD, and dementia in women. A secondary aim was to investigate the influence of socioeconomic status (SES) on the relationship. Methods: In total, 9584 participants from the Australian Longitudinal Study on Women's Health (ALSWH) 1946¿1951 cohort, with diet information from Food Frequency Questionnaires in 2001 and outcomes assessed at 2020. Five food clusters were identified using the K-means approach. Cox models were used to obtain hazard ratios (HRs) and 95% CIs for all-cause mortality, CVD and dementia according to quarters of the ARFS and MDFS and by food group clusters, with final models adjusted for health status, behaviors and SES. Results: There were 656 deaths, 1585 incidents of CVD and 165 dementia diagnoses during 17.2 years of follow-up. For all-cause mortality, HRs comparing the highest (best) to lowest quarter of diet quality were 0.60 (95% CI: 0.46, 0.78; P < 0.001) for the ARFS, 0.64 (95% CI: 0.47, 0.87; P = 0.005) for the MDFS, and 0.67 (95% CI: 0.47, 0.95; P = 0.02) when comparing a diet higher in protein intake and lower milk/yogurt intake to diets higher in discretionary foods and lower in fruit and vegetables. There were no associations between diet indices with CVD and dementia outcomes or influence of SES on findings. Conclusions: Better quality diets were associated with a lower risk of all-cause mortality, and there were no associations identified between diet and CVD or dementia outcomes. These findings provide insights into the potential benefits of improving diet quality of Australian women to improve longevity.
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| 2025 |
Gebresillassie BM, Attia J, Cavenagh D, Harris ML, 'Development and Validation of a Risk Prediction Model to Identify Women With Chronic Obstructive Pulmonary Disease for Proactive Palliative Care', Respirology, 30, 623-632 (2025) [C1]
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| 2025 |
Gebresillassie BM, Attia J, Cavenagh D, Harris ML, 'Development, validation, and clinical utility of a risk prediction model to identify older women with dementia for proactive palliative care', Archives of Gerontology and Geriatrics, 134 (2025) [C1]
Background: Accurately estimating one-year mortality risk in older women with dementia can inform clinical decision-making, facilitate timely advanced care planning, an... [more]
Background: Accurately estimating one-year mortality risk in older women with dementia can inform clinical decision-making, facilitate timely advanced care planning, and optimise palliative care delivery. This study aimed to develop, validate, and assess the clinical utility of a prediction model for one-year all-cause mortality in this population using a nationally representative Australian cohort. Methods: This prognostic study utilised data from the 1921¿26 cohort of the nationally representative, population-based Australian Longitudinal Study on Women's Health (ALSWH) and linked national and state-based administrative health records. Candidate predictors were identified through a systematic review and expert consultation, then refined using a data-driven statistical approach. A multivariable binary logistic regression model was developed and validated to predict one-year all-cause mortality. Results: The analysis included 1576 older women with dementia (mean age, 72.6 ± 1.5 years). The model demonstrated good discrimination (AUC: 75.1 %, 95 % CI: 72.7 %¿77.5 %) and excellent calibration (slope = 1.00, 95 % CI: 0.87¿1.13; intercept = 0.00, 95 % CI: 0.11 ¿ 0.11). Model validation using both 10-fold cross-validation and 1000 bootstrap iterations showed minimal optimism in its predictive performance, with AUC optimism of 0.0047 and 0.0042, respectively. Decision curve analysis indicated a net benefit across probability thresholds from 0.24 to 0.88, supporting the model's clinical utility for guiding palliative care decisions. Conclusion: This prediction model, incorporating readily available predictors, demonstrated compelling performance and clinical utility for identifying older women with dementia at high risk of one-year mortality. The model has the potential to facilitate timely palliative care interventions and is publicly accessible via a web-based calculator. Further external validation in diverse populations and healthcare settings is warranted to confirm its generalisability.
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| 2024 |
Dingle SE, Bowe SJ, Bujtor M, Milte CM, Daly RM, Byles J, Cavenagh D, Torres SJ, 'Data-driven lifestyle patterns and risk of dementia in older Australianwomen', ALZHEIMERS & DEMENTIA, 20, 798-808 (2024) [C1]
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Open Research Newcastle |
| 2023 |
Nepal S, Dolja-Gore X, Cavenagh D, D'Este C, Anstey KJ, Brodaty H, Welberry HJ, Goh AMY, McNamara M, 'Addressing Dementia Through Analysis of Population Traits and Risk Factors (ADAPTOR) project: dementia incidence in an Australian cohort', PUBLIC HEALTH RESEARCH & PRACTICE, 33 (2023) [C1]
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Open Research Newcastle |
| 2023 |
Bizuayehu HM, Harris ML, Chojenta C, Cavenagh D, Forder PM, Loxton D, 'Patterns of Labour Interventions and Associated Maternal Biopsychosocial Factors in Australia: a Path Analysis', REPRODUCTIVE SCIENCES, 30, 2767-2779 (2023) [C1]
In Australia, nearly half of births involve labour interventions. Prior research in this area has relied on cross-sectional and administrative health data and has not c... [more]
In Australia, nearly half of births involve labour interventions. Prior research in this area has relied on cross-sectional and administrative health data and has not considered biopsychosocial factors. The current study examined direct and indirect associations between biopsychosocial factors and labour interventions using 19¿years of population-based prospective data. The study included singleton babies among primiparous women of the 1973¿1978 cohort of the Australian Longitudinal Study on Women's Health. Data from 5459 women who started labour were analysed using path analysis. 42.2% of babies were born without intervention (episiotomy, instrumental, or caesarean delivery): Thirty-seven percent reported vaginal birth with episiotomy and instrumental birth interventions, 18% reported an unplanned caesarean section without episiotomy and/or instrumental interventions, and 3% reported unplanned caesarean section after episiotomy and/or instrumental interventions. Vaginal births with episiotomy and/or instrumental interventions were more likely among women with chronic hypertension (RRR(95%-CI):1.50(1.12¿2.01)), a perceived length of labour of more than 36¿h (RRR(95%-CI):1.86(1.45¿2.39)), private health insurance (RRR(95%-CI):1.61(1.41¿1.85)) and induced labour (RRR(95%-CI):1.69(1.46¿1.94)). Risk factors of unplanned caesarean section without episiotomy and/or instrumental birth intervention included being overweight (RRR(95%-CI):1.30(1.07¿1.58)) or obese prepregnancy (RRR(95%-CI):1.63(1.28¿2.08)), aged = 35¿years (RRR(95%-CI):1.87(1.46¿2.41)), having short stature (< 154¿cm) (RRR(95%-CI):1.68(1.16¿2.42)), a perceived length of labour of more than 36¿h (RRR(95%-CI):3.26(2.50¿4.24)), private health insurance (RRR(95%-CI):1.38(1.17¿1.64)), and induced labour (RRR(95%-CI):2.56(2.16¿3.05)). Prevention and management of hypertension, diabetes, and obesity during preconception and/or antenatal care are keys for reducing labour interventions and strengthening the evidence-base around delivery of best practice obstetric care.
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Open Research Newcastle |
| 2023 |
Byles J, Cavenagh D, Bryant J, Carey M, Mazza D, Sanson-Fisher R, 'Do health assessments affect time to permanent residential aged care admission for older women with and without dementia?', GERIATRICS & GERONTOLOGY INTERNATIONAL, 23, 595-602 (2023) [C1]
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Open Research Newcastle |
| 2022 |
White J, Hambisa MT, Cavenagh D, Dolja-Gore X, Byles J, 'Understanding the relationship between eye disease and driving in very old Australian women: a longitudinal thematic evaluation', BMC OPHTHALMOLOGY, 22 (2022) [C1]
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Open Research Newcastle |
| 2021 |
White J, Cavenagh D, Byles J, Mishra G, Tooth L, Loxton D, 'The experience of delayed health care access during the COVID 19 pandemic in Australian women: A mixed methods exploration', HEALTH & SOCIAL CARE IN THE COMMUNITY, 30, E1384-E1395 (2021) [C1]
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Open Research Newcastle |
| 2021 |
Loxton D, Forder PM, Cavenagh D, Townsend N, Holliday E, Chojenta C, Melka AS, 'The impact of adverse childhood experiences on the health and health behaviors of young Australian women', CHILD ABUSE & NEGLECT, 111 (2021) [C1]
Background: Adverse childhood experiences have been linked to poor health and adverse health behavior in adulthood. Objective: This study aimed to estimate the prevalen... [more]
Background: Adverse childhood experiences have been linked to poor health and adverse health behavior in adulthood. Objective: This study aimed to estimate the prevalence of adverse childhood experiences among young Australian women (aged 20¿25) and examine associations between adverse childhood experiences and adult health behaviors and physical and mental health. Participants and Settings: Data were from the 1989-95 cohort of the Australian Longitudinal Study on Women's Health, who completed the Adverse Childhood Experiences Scale at Survey 3 in 2015 (N = 8609). Methods: Outcomes included: self-rated health, sexual health, psychological distress, depression, anxiety, suicide ideation, self-harm, substance abuse (drinking, smoking, illicit drugs), severe obesity, and exercise. Prevalence of childhood adversities were presented, with the association between childhood adversity and outcomes evaluated using log-binomial multivariable regressions (99% CI). Results: While 59% of women reported experiencing at least one childhood adversity, 10% of participants reported adverse childhood experiences across four or more categories, indicating a significant burden of risk for young Australian women. Women reporting four or more categories had higher rates of poor physical health (adjPR = 1.79, 99% CI = 1.51¿2.12), sexually transmitted infections (adjPR = 1.36, 99% CI = 1.11¿1.67), and poor mental health (adjPR = 2.78, 99% CI = 2.34¿3.32), and increased rates of severe obesity (adjPR = 2.14, 99% CI = 1.61¿2.86) and smoking (adjPR = 2.23, 99% CI = 1.89¿2.64). Conclusion: Using nationally representative data, this study shows adverse childhood experiences directly impact physical and mental health, and health behaviors in adulthood among young Australian women. The management of health and wellbeing in adulthood should look beyond the contemporaneous factors, incorporating a focus on how childhood adversity may negatively influence health behavior, health and wellbeing in later life.
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Open Research Newcastle |
| 2021 |
Byles J, Cavenagh D, Bryant J, Mazza D, Browning C, O'Loughlin S, Sanson-Fisher R, 'Use of medical services by older Australian women with dementia: a longitudinal cohort study', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, 45, 497-503 (2021) [C1]
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Open Research Newcastle |
| 2020 |
Thiruchelvam K, Byles J, Hasan SS, Egan N, Cavenagh D, Kairuz T, 'Common combinations of medications used among oldest-old women: a population-based study over 15 years', AGING CLINICAL AND EXPERIMENTAL RESEARCH, 33, 1919-1928 (2020) [C1]
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Open Research Newcastle |
| 2020 |
Anderson AE, Cavenagh D, Forder P, Loxton D, Byles J, 'Alcohol-related risk from pre-loading and heavy episodic drinking (HED) among a cohort of young Australian women: a cross-sectional analysis', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, 44, 382-389 (2020) [C1]
Objective: To cross-sectionally examine heavy episodic drinking (HED) and pre-loading with alcohol among young Australian women in relation to the alcohol-induced adver... [more]
Objective: To cross-sectionally examine heavy episodic drinking (HED) and pre-loading with alcohol among young Australian women in relation to the alcohol-induced adverse outcomes of memory loss, vomiting and injury. Methods: A total of 7,800 participants, aged 20¿25 years, from the 1989¿95 cohort of the Australian Longitudinal Study on Women's Health answered all questions on alcohol use, reported drinking alcohol in the previous year and were not pregnant at the third survey in 2015. Log-binomial models were used to estimate prevalence ratios for adverse outcomes associated with increased frequency of HED and pre-loading. Results: The majority of participants reported HED (83.4%) and/or pre-loading (65.6%), which had a moderate correlation (r=0.646). Just over half (55.2%) of participants experienced at least one adverse event, with vomiting being most common. As the frequency of HED or pre-loading increased, so did the risk of an adverse outcome. Conclusions: Both HED and pre-loading pose a risk to young Australian women, and that risk rises with increased frequency. Implications for public health: Although HED has been a target of public health policy and interventions, pre-loading has received limited attention. In addition to addressing HED, there is a need to consider the risk posed by pre-loading, a related, yet unique risky drinking behaviour.
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Open Research Newcastle |