Professor Alan Brichta
Professor
School of Biomedical Sciences and Pharmacy (Anatomy)
- Email:alan.brichta@newcastle.edu.au
- Phone:(02) 4921 7026
Deciphering the Balance Code
Tucked away deep in the hardest part of the skull hides the vestibular system, the mysterious unsung hero of the senses. Professor Alan Brichta is its number one fan.
"We need the vestibular system for balance, it is specifically there to tell us, amongst other things, which way is up and which way is down," Alan asserts.
"What is fascinating to me is that most of the time we just don't think about it. We don't realise this thing is working in our favour until it goes wrong."
The relatively recent recognition of the existence of the sense of balance, as well as the inaccessible position of the inner ear vestibular organs within the skull, means there is a lack of evidence-based research on this system in action.
To counter this, Alan and his team have developed a semi-intact model of the vestibular system, which allows for live cells to remain functional.
"We are concentrating on the peripheral balance organs, the ones out in the inner ear, to see how they work, and how they communicate with the brain," he clarifies.
"People talk about exploring outer space, really we are flipping that idea on its head and are trying to discover inner space."
When not investigating the inner ear, Alan is Head of Discipline (Anatomy), supervisor of multiple research students, and teaching into a number of programs including the Bachelor of Medicine and the Bachelor of Biomedical Science.
TEAM VESTIBULAR
If you were a mysterious and misunderstood body part, Alan would be your first choice for advocate.
His extensive knowledge and unbridled fascination are equally apparent as he talks up the balance system. He embodies a fervent team supporter as he derides the other senses for not being nearly as important.
"The vestibular system is how you remember which direction you came from, and is responsible for you knowing where you are as you move through your environment," Alan explains.
"You can thank it for your awareness of whether you are lying down or standing up, and for knowing which way to swim to reach the surface of the water."
"Importantly, it keeps your eyes steady when your body is moving, so your vision is more steadycam than jumpy jumble. It is so finely tuned," he discloses, "that drinking alcohol can cause it to make you wobbly, and echo wobbly the next day as it works to compensate for your previous night's wobbliness."
Unlike the other senses, the vestibular organs don't report back to one specific part of the brain, instead sending and receiving communications with many sections of the brain. Which Alan believes is proof of the critical importance of balance information to normal brain function.
"I think it's the way it works so exquisitely well for the most part that really fascinates me," Alan muses.
"What is also fascinating to me, is that most of the time we just don't think about it."
"The balance system works so well and with such little fanfare, that when something goes wrong our world is thrown into complete disarray."
DEVASTATING DIZZINESS
Alan explains that malfunction within the vestibular system can have devastating affects on quality of life.
"The balance system itself will never kill you directly, but the resulting falls, especially in the aged, can lead to fatal consequences," Alan asserts.
"Breaking a leg, or worse still a pelvis, that's going to lead to all sorts of problems."
It's not just fear of injury that affects those with dizziness. Alan cites understandable anxiety over the possibility of creating a scene or damaging property whilst falling, as two scenarios which may make sufferers stay at home.
Due to the similarities between the effects of excessive alcohol and balance problems, accusations of drunkenness can cause further embarrassment.
"It's remarkable how quickly people do lose confidence," Alan reveals.
"And as a result, it's a hidden problem because we rarely, if ever, see people with balance problems, they are not generally out in the community."
"Whenever we have a public forum on balance and dizziness, however, it's amazing how many people attend because they are desperate to find a cure for themselves or their loved ones."
MINOR MODULATION AND MAJOR MYSTERY
Milder effects of vestibular interruption are relatively common and can be countered.
"The brain is capable of a lot of plasticity, or modulation," Alan states.
"If the brain recognises that the signals aren't coming in quite as well as they used to, it might amplify or boost the incoming signal."
"But it can only do so much to compensate. People who have tried everything, from physiotherapy to medications to operations with little or no effect can have a very poor quality of life."
Despite the debilitating nature of balance problems, a lack of knowledge in this area means that optimum treatments are yet to be identified.
"The sad thing is we have no real treatment. We can give you sedatives; we can give you things that reduce your activity and maybe your anxiety," Alan says.
"But really there is nothing at all we can do to stop that dizziness. Because we don't know how it works, we don't know what happens when it goes wrong, or what drugs could be specifically aimed at treating the problem."
"And this is why we need more studies."
MONITORING THE MACHINE IN MOTION
The balance system is almost completely inaccessible, positioned within the thickest part of the skull, rendering the study of its working actions very difficult.
"Using an animal model, we were amongst the first to look at it as a semi-intact system, that's our specialty," Alan confirms.
As a result of their use of this system, Alan and his team have been able to test existing theoretical frameworks and generate evidence regarding previously unobserved functions.
"We can't always learn about functions from studying the parts, or by using modeling," Alan explains.
"We are at such a primitive stage of understanding that we need to study the system in action to advance our knowledge."
His most recent NHMRC-funded research has focused on the efferent branch of the vestibular system – the feedback pathway by which the brain can modulate inner ear sensitivity.
BALANCE PROSTHESIS
Ultimately, Alan is hoping that the work being completed by his team will result in a major improvement in the quality of life of people suffering from balance problems.
"By listening in on the communication between the inner ear organs and the brain, we are trying to decode the kinds of information that the brain is interested in," Alan explains.
"And if we do that, then maybe we can replace it if it is damaged, or supplement it as we age."
Although we accept that our hearing is likely to be affected by age, Alan points out that it is less commonly understood that balance, which uses similar receptors or sensory cells, can also be impacted by aging.
"So if we could develop a system whereby you had a prosthesis or an aid, that would be a boon to anyone who has balance problems, particularly the elderly."
Alan notes that technologies such as accelerometers and gyroscopes have shrunk in size and cost to the extent that they could be easily incorporated into a non-obtrusive aid.
"It could be like a hearing aid, but for the balance system," Alan suggests.
"It might be on a set of glasses, or possibly it could be a chip close to, or attached to the skull. It would then generate electric signals that would help the brain to know the position of our head in three-dimensional space."
"It's one of our major goals. But first we have to understand how it works to be able to fix it," he admits.
"At least in our case, because there is not that much known about it, and so few people working on it, we might just discover something really important tomorrow."
"Usually though, it's just little 'balanced' steps toward gaining more knowledge."
Deciphering the Balance Code
Professor Alan Brichta's primary research interest is balance and the vestibular system.
Alan Brichta
Professor Alan Brichta's primary research interest is balance and the vestibular system. His most recent NHMRC-funded research has focused on the efferent branch of the vestibular system – the pathway by which the brain can modulate inner ear sensitivity.
Despite fifty years of ongoing research, the functional purpose of the efferent vestibular system still remains a mystery – most likely due to its inherently complex mechanisms of action. To combat this, Alan has developed a semi-intact model of the vestibular system, which allows for faithful, high-resolution recordings of hair cell function. This recording technique has provided new information about the efferent vestibular system, with particular regards to the novel alpha-9 nicotinic receptor.
Alan has ongoing collaborations with vestibular experts Dr Americo Migliaccio (Neuroscience Research Australia; NeuRA), Dr Joseph Holt (University of Rochester, USA) and Dr Richard Rabbitt (University of Utah, USA), as well as HMRI neuroscientists Professor Bob Callister and Dr Doug Smith. He is also closely affiliated with the Garnett Passe and Rodney Williams Memorial Foundation (GPRWMF), and the Neuro-Otology Society of Australia (NOTSA). Alan is currently the Head of Discipline (Anatomy), supervises multiple PhD students, and teaches into a number of programs including Bachelor of Medicine and Bachelor of Biomedical Science.
What intrigues you most about the vestibular system?
I know it may sound a little strange but almost from the moment I learned about the vestibular system, I've been fascinated and intrigued by the subtle and mysterious way it works to provide us with a sense of balance.
The vestibular system allows us go about our daily activities, correcting almost every move we make, so that we don't fall over. And it does this with little or no fanfare or even very much recognition. The vestibular system is neither blatant nor does it intrude on our consciousness with the flamboyance of primary senses such as vision and hearing. If the vestibular system is doing its job properly it is almost imperceptible, working away with exquisite precision, speed, and accuracy. Perhaps it is precisely this 'backstage activity' that is responsible for our general lack of awareness and why we know so much less about this system in comparison to its close cousin, the hearing or auditory system. In short, the more I get to know the vestibular system the more I am in awe of the 'no nonsense' way in which it influences almost all aspects of our lives, making it the 'quiet achiever', or dare I say, the unsung hero or heroine of the central nervous system.
Alan Brichta
Professor Alan Brichta's primary research interest is balance and the vestibular system. His recent research has focused on the efferent branch of the vestibu
Career Summary
Biography
Alan Brichta is a neurobiologist with research interests in the anatomy and physiology of peripheral and central vestibular system. In particular, his studies have focused on vestibular hair cells and their associated primary afferents and has recently developed an isolated preparation of the mouse inner ear to study these unusual cellular components. This approach allows stable, high-resolution, intracellular recordings whilst the tissue undergoes near 'natural' (mechanical), rather than artificial (electrical) stimulation. Results from these studies are helping us understand the cellular mechanisms underlying normal and abnormal function associated with the peripheral vestibular apparatus. In addition, Dr. Brichta is studying vestibular nucleus neurons in the brainstem that are the major recipients of transmitted vestibular organ output. These regions are thought to be highly modifiable and may prove to be ideal targets for rational therapeutic strategies aimed at treating balance disorders. Dr. Brichta was awarded a prestigious five year Garnett Passe and Rodney Williams Memorial Foundation Senior/Principal Research Fellowship.
Research ExpertiseVestibular electrophysiological and anatomical techniques, including whole-cell patch-clamp recordings together with intracellular labelling and immunohistochemistry. Experience with in vivo and in vitro preparations. Awarded major nationally competitive grants: Continually funded NHMRC Project Grants; Garnett Passe and Rodney Williams Memorial Foundation Invited Speaker at the Royal College of Medicine, London, UK.
Teaching Expertise
Head of the Anatomy and his teaching expertise is in histology, neuroanatomy, and neurosicence. Has helped with major reorganisation of core anatomy courses to Medicine, Biomed Sci, Health Sciences, including Medical Radiation Science, Physiotherapy, Oral Health, and Speech Pathology. Developed three new specialist subjects: Oral Health, Speech Pathology, and Neural Visceral Anatomy. Re-designed second semester Neuroanatomy block for Medicine. Hosted the Universitys first US Fulbright Scholar. Help organise teaching in new Anatomy facility - Medical Sciences West.
Administrative Expertise
Currently, Director of the University of Newcastle Priority Research Centre for Brain and Mental Health. Is an NHMRC Assigners Academy member, an Associate Editor for the Journal of Association for Research in Otolaryngology, and is the Chair of the International Committee of the Association for Research in Otolaryngology. Former member of University Research Committee, Academic Senate, and Faculty Board during a period of major change in teaching and learning at the University. Attracted significant equipment funding to the EM /X-Ray Unit with a successful application for nationally competitive ARC-LEIF grant. Submission of Anatomy discipline Roadmap for Australian Medical Accreditation Committee. Contributed to the development of the Bachelor of Podiatry Program. Provided Biomedical Science input with regard to course provisions and assessment of background course pre-requisites. Member of NHMRC Grant Review Panels. External Ph.D. Examiner of Higher Degree Research Students.
Collaborations
In addition to his own studies on the vestibular system, Dr. Brichta has had a long-term collaboration with his good friend and colleague, Dr. Bob Callister. Together they have had over thirty years of collaborative efforts on sensory and motors systems. In addition Dr. Brichta collaborations with Neuroscience Research Australia (Sydney), the University of Utah, University of Rochester, and University College London.
Qualifications
- PhD, Ohio University - USA
- Bachelor of Science (Anatomy), University of New South Wales
Keywords
- Anatomy
- Electrophysiology
- Neuroscience
- Vestibular system
Fields of Research
Code | Description | Percentage |
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320907 | Sensory systems | 100 |
Professional Experience
UON Appointment
Title | Organisation / Department |
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Professor | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Academic appointment
Dates | Title | Organisation / Department |
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1/1/2015 - | Director | Priority Research Centre for Brain and Mental Health | The University of Newcastle Australia |
1/1/2013 - | Head of Anatomy Discipline | The University of Newcastle - Faculty of Health and Medicine School of Biomedical Sciences and Pharmacy Australia |
1/7/2008 - 1/6/2013 |
Senior/Principal Research Fellowship Garnett Passe and Rodney Williams Memorial Foundation |
University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
1/7/2007 - 31/12/2014 | Associate Professor. | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
1/11/1998 - 1/12/2000 | Lecturer | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
1/7/1995 - 1/10/1998 | Assistant Professor | University of Chicago, Chicago, Illinois Physiological and Pharmacological Sciences United States |
Membership
Dates | Title | Organisation / Department |
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1/1/2014 - | Membership - NHMRC Assigners Academy Committee | NHMRC Committee Australia |
1/1/2014 - | Chair - ARO International Committee | ARO International Committee Australia |
1/1/2011 - 31/12/2013 | Membership - NHMRC Committee | NHMRC (National Health & Medical Research Council) |
Invitations
Participant
Year | Title / Rationale |
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2012 |
A Question of Balance: The best-laid schemes o' mice an' men Organisation: The Royal Society of Medicine, London Description: Much of what we have learned about the human body has come not from direct observations but has been inferred from animal studies. Fortunately, as we have learned from the human and other genome projects, we are almost genetically identical to chimpanzees and remarkably similar to mice. Sequencing of the mouse genome for example, completed in late 2002, estimates a gene count of 23,786 and for comparison, humans are estimated to have 23,686 genes – a hundred fewer! Therefore, it can be argued that what we learn in mice is applicable to humans. This assertion is most likely true when it comes to ancient and evolutionarily conservative sensory systems such as the peripheral vestibular system. To date, however, its residence deep within the hardest bone of the skull (making it neither easy to access nor convenient to manipulate) has hampered our study of the vestibular organs of the inner ear. To overcome this significant technical obstacle we have developed a surgically isolated inner ear of the mouse. This preparation allows us unprecedented access to the workings of the organs of balance. Indeed, using our isolated in vitro preparation and altering the volume of inner ear fluid by only a few nano-litres we have observed anomalous neuronal activity that may contribute to the symptoms of Meniere’s disease. By stripping the isolated inner ear preparation still further, (like layers in an onion) but carefully preserving the important and unique micro-architectural features of the individual organs, we have discovered a novel way in which the important motion detectors of the vestibular system (hair cells) communicate with their closely associated nerve afferent nerves. These results would have been difficult if not impossible to obtain without semi-intact preparations of vestibular organs. Despite these notable advances one must acknowledge that these results are from a very small mammal that weighs four orders of magnitude less than an adult human (7 grams vs. 70 kilograms). Therefore, are any of these findings relevant to humans? To address this fundamental issue we have begun to isolate viable inner ears from post-mortem human foetal tissue (10 to 18 weeks gestation). This means we can now apply some of the techniques we have learned using mice to in vitro human vestibular tissue. The preliminary results are promising. We are able to record activity from foetal hair cells and nerve terminals up to 8 hours after the tissue arrives in the laboratory. Our data suggest the human peripheral vestibular system is fully functional midway through the second trimester and indeed resembles a 3 week old, fully weaned, postnatal mouse. Taken together, these various approaches provide us with new insights into basic machinery of the peripheral balance organs in humans. Our ultimate goal is to have the findings from these animal and foetal models translated into targeted clinical therapeutics. For example, due to pathological increases in endolymph volume, we believe the membranous labyrinth is distended causing abnormal and confusing signals to the brain. Alleviating these volume changes by pharmacological and/or surgical intervention would eliminate distensions and accompanying vertiginous attacks. Similarly, based on our new understanding of the key role potassium plays in vestibular organ function, particularly between hair cells and primary afferents, suggests this ion is tightly regulated to ensure normal balance function. Thus a focus on restoration and maintenance of potassium in the inner ear would be a clinical requirement. In short, our continued hope is that better basic understanding leads to targeted diagnostic and therapeutic strategies for treating the debilitating effects of balance disorders. |
2006 |
Developments in isolated inner ear preparations Organisation: Garnett Passe and Rodney Williams Foundation Description: Inivited speaker |
2002 |
Transduction in vestibular sense organs Organisation: The Australian Health and Medical Research Congress Description: Inivited speaker |
2001 |
Vestibular Influences on Movement Organisation: International B¿r¿ny Society Description: Inivited Speaker |
Speaker
Year | Title / Rationale |
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2010 |
The unusual calyx terminals of the inner ear Organisation: Barany Society Meeting |
Teaching
Code | Course | Role | Duration |
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MEDI1015 |
Medical Science - Histology The University of Newcastle - Faculty of Health and Medicine |
Presenter | 11/7/2011 - 31/12/2049 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (7 outputs)
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2023 |
Goldberg JM, Brichta AM, Wackym PA, 'Efferent Vestibular System: Anatomy, Physiology, and Neurochemistry', Neurochemistry of the Vestibular System 61-94 (2023) Most efferent vestibular neurons contain choline acetyltransferase and acetylcholinesterase. The labeling of the efferent neurons was an important step that led within a few years... [more] Most efferent vestibular neurons contain choline acetyltransferase and acetylcholinesterase. The labeling of the efferent neurons was an important step that led within a few years to studies of the effects of efferent stimulation on afferent discharge, as well as to later studies of the neurochemistry of efferent transmission. This chapter considers the locations of efferent cell bodies in mammals and compares the results with those obtained in other vertebrate species. The course of the efferent axons from the brain stem to the ear will only be described in mammals. There are striking variations in the efferent responses of afferents innervating different parts of the neuroepithelium and differing in their responses to natural stimulation. To understand the diversity of efferent responses, one need to consider the regional organization of the endorgans. Since the organization differs across species, separate sections are devoted to mammals, toadfish, and turtles. The chapter also reviews the role of substances that may function as efferent neurotransmitters.
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2012 |
Lim R, Brichta AM, 'Vestibular system', The Mouse Nervous System, Academic Press, San Diego 661-678 (2012) [B1]
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2011 |
Lim R, Brichta AM, 'Vestibular System', The Mouse Nervous System 661-681 (2011) The peripheral vestibular apparatus is housed within the petrous portion of the temporal bone. It consists of an outer protective bony labyrinth that encases a system of interconn... [more] The peripheral vestibular apparatus is housed within the petrous portion of the temporal bone. It consists of an outer protective bony labyrinth that encases a system of interconnected fluid-filled ducts called the membranous labyrinth. The vestibular labyrinth is comprised of three nearly orthogonal semicircular canals, anterior (superior), posterior (inferior), and horizontal (lateral), and two enlarged chambers that form the utricle and saccule. Each bony semicircular canal contains a curved membranous duct and an enlarged ampulla. Within each ampulla is a neuroepithelial crest or crista, in which are embedded the sensory hair cells, interdigitating supporting cells, and afferent and efferent nerve fibers. Together this ensemble detects angular acceleration of the head and transmits this signal via the ampullary branches of the vestibulocochlear nerve to the central nervous system (CNS). The utricle and saccule lie within the two enlarged bony chambers that are perpendicular to each other, and each contains a flattened neuroepithelial patch called a macula that also consists of hair cells, supporting cells, and nerve fibers. As components of a modified epithelium, vestibular hair cells and supporting cells separate two dissimilar fluids. Endolymph, found inside the membranous labyrinth, has a high potassium concentration; and perilymph, bathing the outside of the membranous labyrinth, has a composition similar to extracellular fluid. There are approximately 3,500 vestibular neurons in mouse Scarpa's ganglion, which are divided equally among the five organs with an estimated 680 to each. Since there are many more hair cells in macular organs, it follows that the ratio of hair cells to utricular and saccular afferents are greater. Despite an early study on the central projections of vestibular afferents in mice, much less information is available on central vestibular nuclei in this animal.
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2001 |
Stuart DG, Pierce PA, Callister RJ, Brichta AM, McDonagh JC, 'Sir Charles Sherrington: Humanist, Mentor, and Movement Neuroscientist', Classics in Movement Science, Human Kinetics, U.S.A. 317-374 (2001) [B2]
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2000 | Goldberg J, Brichta AM, Wackym P, 'Efferent Vestibular System: Anatomy, Physiology, and Neurochemistry', Neurochemistry of the Vestibular System, CRC Press, Washington, D.C., U.S.A. 411 (2000) [B1] | |||||||
1999 |
McDonagh J, Callister RJ, Brichta AM, Stuart D, 'A commentary on the properties of spinal interneurons vs. motoneurons in vertebrates and their firing-rate behaviour during movement', Motor Control: Today and Tomorrow, Academic Publishing House "Prof.Marin Drinov", Sofia, Bulgaria 3-29 (1999) [B1]
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Journal article (82 outputs)
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2023 |
Liebenberg A, Nie VM, Brichta AM, Ahmadi S, James CL, 'Pre-employment hearing threshold levels of 59,601 Australian male coal miners compared to an otologically normal international male population (ISO7029:2019).', Int J Audiol, 62 729-737 (2023) [C1]
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2023 |
Poppi LA, Bigland MJ, Cresswell ET, Tabatabaee H, Lorincz D, Drury HR, et al., 'Molecular and Functional Changes to Postsynaptic Cholinergic Signaling in the Vestibular Sensory Organs of Aging C57BL/6 Mice.', J Gerontol A Biol Sci Med Sci, 78 920-929 (2023) [C1]
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2023 |
Sherwood CP, Crovador R, Posar JA, Brichta N, Simunovic MP, Louie F, et al., 'Design Parameters and Human Biocompatibility Assessment Protocols for Organic Semiconducting Neural Interfaces: Toward a Printed Artificial Retina with Color Vision', ADVANCED MATERIALS INTERFACES, [C1]
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2023 |
Lorincz D, Drury HR, Smith DW, Lim R, Brichta AM, 'Aged mice are less susceptible to motion sickness and show decreased efferent vestibular activity compared to young adults.', Brain and behavior, 13 e3064 (2023) [C1]
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2022 |
Lorincz D, Poppi LA, Holt JC, Drury HR, Lim R, Brichta AM, 'The Long and Winding Road Vestibular Efferent Anatomy in Mice', Frontiers in Neural Circuits, 15 (2022) [C1] The precise functional role of the Efferent Vestibular System (EVS) is still unclear, but the auditory olivocochlear efferent system has served as a reasonable model on the effect... [more] The precise functional role of the Efferent Vestibular System (EVS) is still unclear, but the auditory olivocochlear efferent system has served as a reasonable model on the effects of a cholinergic and peptidergic input on inner ear organs. However, it is important to appreciate the similarities and differences in the structure of the two efferent systems, especially within the same animal model. Here, we examine the anatomy of the mouse EVS, from its central origin in the Efferent Vestibular Nucleus (EVN) of the brainstem, to its peripheral terminations in the vestibular organs, and we compare these findings to known mouse olivocochlear anatomy. Using transgenic mouse lines and two different tracing strategies, we examine central and peripheral anatomical patterning, as well as the anatomical pathway of EVS axons as they leave the mouse brainstem. We separately tag the left and right efferent vestibular nuclei (EVN) using Cre-dependent, adeno-associated virus (AAV)-mediated expression of fluorescent reporters to map their central trajectory and their peripheral terminal fields. We couple this with Fluro-Gold retrograde labeling to quantify the proportion of ipsi- and contralaterally projecting cholinergic efferent neurons. As in some other mammals, the mouse EVN comprises one group of neurons located dorsal to the facial genu, close to the vestibular nuclei complex (VNC). There is an average of just 53 EVN neurons with rich dendritic arborizations towards the VNC. The majority of EVN neurons, 55%, project to the contralateral eighth nerve, crossing the midline rostral to the EVN, and 32% project to the ipsilateral eighth nerve. The vestibular organs, therefore, receive bilateral EVN innervation, but without the distinctive zonal innervation patterns suggested in gerbil. Similar to gerbil, however, our data also suggest that individual EVN neurons do not project bilaterally in mice. Taken together, these data provide a detailed map of EVN neurons from the brainstem to the periphery and strong anatomical support for a dominant contralateral efferent innervation in mammals.
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2022 |
Khan S, Brichta AM, Migliaccio AA, 'A Once-Daily High Dose of Intraperitoneal Ascorbate Improves Vestibulo-ocular Reflex Compensation After Unilateral Labyrinthectomy in the Mouse', JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 23 27-34 (2022) [C1]
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2022 |
Stitt IM, Wellings TP, Drury HR, Jobling P, Callister RJ, Brichta AM, Lim R, 'Properties of Deiters? neurons and inhibitory synaptic transmission in the mouse lateral vestibular nucleus', JOURNAL OF NEUROPHYSIOLOGY, 128 131-147 (2022) [C1]
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2022 |
Khan S, Huebner PP, Brichta AM, Migliaccio AA, 'Vestibulo-Ocular Reflex Short-Term Adaptation Is Halved After Compensation for Unilateral Labyrinthectomy', JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 23 457-466 (2022) [C1]
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2021 |
Liebenberg A, Brichta AM, Nie VM, Ahmadi S, James CL, 'Hearing threshold levels of Australian coal mine workers: a retrospective cross-sectional study of 64196 audiograms', INTERNATIONAL JOURNAL OF AUDIOLOGY, 60 808-819 (2021) [C1]
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2021 |
Quinn RK, Drury HR, Cresswell ET, Tadros MA, Nayagam BA, Callister RJ, et al., 'Expression and Physiology of Voltage-Gated Sodium Channels in Developing Human Inner Ear', FRONTIERS IN NEUROSCIENCE, 15 (2021) [C1]
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2021 |
Crovador R, Heim H, Cottam S, Feron K, Bhatia V, Louie F, et al., 'Advanced Control of Drug Delivery for in Vivo Health Applications via Highly Biocompatible Self-Assembled Organic Nanoparticles', ACS Applied Bio Materials, 4 6338-6350 (2021) [C1] The use of nanostructured materials for targeted and controlled delivery of bioactive molecules is an attractive alternative to conventional drug administration protocols, enablin... [more] The use of nanostructured materials for targeted and controlled delivery of bioactive molecules is an attractive alternative to conventional drug administration protocols, enabling selective targeting of diseased cells, lower administered dosages, and reduced systemic side effects. Although a variety of nanocarriers have been investigated in recent years, electroactive organic polymer nanoparticles present several exciting advantages. Here we demonstrate that thin films created from nanoparticles synthesized from violanthrone-79, an n-type semiconducting organic material, can incorporate and release dexamethasone in vitro in a highly controlled manner. By systematically altering the nanoparticle formation chemistry, we successfully tailored the size of the nanoparticles between 30 and 145 nm to control the initial amount of drug loaded into the organic particles. The biocompatibility of the different particles was tested using live/dead assays of dorsal root ganglion neurons isolated and cultured from mice, revealing that elevated levels of the sodium dodecyl sulfate surfactant used to create the smaller nanoparticles are cytotoxic; however, cell survival rates in nanoparticles larger than 45 nm exceed 86% and promote neurite growth and elongation. By manipulating the electrical stimulus applied to the electroactive nanoparticle films, we show an accelerated rate of drug release in comparison to passive release in aqueous media. Furthermore, pulsing the electrical stimulus was successfully used to selectively switch the accelerated release rate on and off. By combining the tuning of drug loading (through tailored nanoparticle synthesis) and drug release rate (through electrical stimulus protocols), we demonstrate a highly advanced control of drug delivery dosage in a biocompatible delivery vehicle. This work highlights the significant potential of electroactive organic nanoparticles for implantable devices that can deliver corticosteroids directly to the nervous system for the treatment of inflammation associated with neurological disorders, presenting a translatable pathway toward precision nanomedicine approaches for other drugs and diseases.
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2021 |
Sherwood CP, Elkington DC, Dickinson MR, Belcher WJ, Dastoor PC, Feron K, et al., 'Organic semiconductors for optically triggered neural interfacing: The impact of device architecture in determining response magnitude and polarity', IEEE Journal of Selected Topics in Quantum Electronics, 27 (2021) [C1]
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2020 |
Callister RJ, Brichta AM, Schaefer AT, Graham BA, Stuart DG, 'Pioneers in CNS inhibition: 2. Charles Sherrington and John Eccles on inhibition in spinal and supraspinal structures', BRAIN RESEARCH, 1734 (2020) [C1]
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2020 |
Poppi LA, Holt JC, Lim R, Brichta AM, 'A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications', Journal of Neurophysiology, 123 608-629 (2020) [C1] It has been over 60 years since peripheral efferent vestibular terminals were first identified in mammals, and yet the function of the efferent vestibular system remains obscure. ... [more] It has been over 60 years since peripheral efferent vestibular terminals were first identified in mammals, and yet the function of the efferent vestibular system remains obscure. One reason for the lack of progress may be due to our deficient understanding of the peripheral efferent synapse. Although vestibular efferent terminals were identified as cholinergic less than a decade after their anatomical characterization, the cellular mechanisms that underlie the properties of these synapses have had to be inferred. In this review we examine how recent mammalian studies have begun to reveal both nicotinic and muscarinic effects at these terminals and therefore provide a context for fast and slow responses observed in classic electrophysiological studies of the mammalian efferent vestibular system, nearly 40 years ago. Although incomplete, these new results together with those of recent behavioral studies are helping to unravel the mysterious and perplexing action of the efferent vestibular system. Armed with this information, we may finally appreciate the behavioral framework in which the efferent vestibular system operates.
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2019 |
Geaghan MP, Atkins JR, Brichta AM, Tooney PA, Scott RJ, Carr VJ, Cairns MJ, 'Alteration of miRNA-mRNA interactions in lymphocytes of individuals with schizophrenia', Journal of Psychiatric Research, 112 89-98 (2019) [C1] The aetiology of schizophrenia is complex, heterogeneous, and involves interplay of many genetic and environmental influences. While significant progress has been made in the unde... [more] The aetiology of schizophrenia is complex, heterogeneous, and involves interplay of many genetic and environmental influences. While significant progress has been made in the understanding the common heritable component, we are still grappling with the genomic encoding of environmental risk. One class of molecule that has tremendous potential is miRNA. These molecules are regulated by genetic and environmental factors associated with schizophrenia and have a very significant impact on temporospatial patterns of gene expression. To better understand the relationship between miRNA and gene expression in the disorder we analysed these molecules in RNA isolated from peripheral blood mononuclear cells (PBMCs) obtained from an Australian cohort of 36 individuals with schizophrenia and 15 healthy controls using next-generation RNA sequencing. Significant changes in both mRNA and miRNA expression profiles were observed implicating important interaction networks involved in immune activity and development. We also observed sexual dimorphism, particularly in relation to variation in mRNA, with males showing significantly more differentially expressed genes. Interestingly, while we explored expression in lymphocytes, the systems biology of miRNA-mRNA interactions was suggestive of significant pleiotropy with enrichment of networks related to neuronal activity.
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2019 |
Kennett J, Carter A, Bourne JA, Hall W, Levy N, Mattingley JB, et al., 'A Neuroethics Framework for the Australian Brain Initiative', Neuron, 101 365-369 (2019) [C1] Neuroethics is central to the Australian Brain Initiative's aim to sustain a thriving and responsible neurotechnology industry. Diverse and inclusive community and stakeholde... [more] Neuroethics is central to the Australian Brain Initiative's aim to sustain a thriving and responsible neurotechnology industry. Diverse and inclusive community and stakeholder engagement and a trans-disciplinary approach to neuroethics will be key to the success of the Australian Brain Initiative.
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2019 |
de Oliveira RB, Petiz LL, Lim R, Lipski J, Gravina FS, Brichta AM, et al., 'Crosstalk between mitochondria, calcium channels and actin cytoskeleton modulates noradrenergic activity of locus coeruleus neurons.', Journal of neurochemistry, 149 471-487 (2019) [C1]
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2019 |
Curthoys IS, Grant JW, Pastras CJ, Brown DJ, Burgess AM, Brichta AM, Lim R, 'A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing.', Journal of neurophysiology, 122 259-176 (2019) [C1]
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2018 |
Poppi LA, Tabatabaee H, Drury HR, Jobling P, Callister RJ, Migliaccio AA, et al., 'ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells', Journal of Neurophysiology, 119 312-325 (2018) [C1] In the mammalian vestibular periphery, electrical activation of the efferent vestibular system (EVS) has two effects on afferent activity: 1) it increases background afferent disc... [more] In the mammalian vestibular periphery, electrical activation of the efferent vestibular system (EVS) has two effects on afferent activity: 1) it increases background afferent discharge and 2) decreases afferent sensitivity to rotational stimuli. Although the cellular mechanisms underlying these two contrasting afferent responses remain obscure, we postulated that the reduction in afferent sensitivity was attributed, in part, to the activation of a9- containing nicotinic acetylcholine (ACh) receptors (a9*nAChRs) and small-conductance potassium channels (SK) in vestibular type II hair cells, as demonstrated in the peripheral vestibular system of other vertebrates. To test this hypothesis, we examined the effects of the predominant EVS neurotransmitter ACh on vestibular type II hair cells from wild-type (wt) and a9-subunit nAChR knockout (a9 -/- ) mice. Immunostaining for choline acetyltransferase revealed there were no obvious gross morphological differences in the peripheral EVS innervation among any of these strains. ACh application onto wt type II hair cells, at resting potentials, produced a fast inward current followed by a slower outward current, resulting in membrane hyperpolarization and decreased membrane resistance. Hyperpolarization and decreased resistance were due to gating of SK channels. Consistent with activation of a9*nAChRs and SK channels, these ACh-sensitive currents were antagonized by the a9*nAChR blocker strychnine and SK blockers apamin and tamapin. Type II hair cells from a9 -/- mice, however, failed to respond to ACh at all. These results confirm the critical importance of a9nAChRs in efferent modulation of mammalian type II vestibular hair cells. Application of exogenous ACh reduces electrical impedance, thereby decreasing type II hair cell sensitivity. NEW & NOTEWORTHY Expression of a9 nicotinic subunit was crucial for fast cholinergic modulation of mammalian vestibular type II hair cells. These findings show a multifaceted efferent mechanism for altering hair cell membrane potential and decreasing membrane resistance that should reduce sensitivity to hair bundle displacements.
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2018 |
Bigland MJ, Brichta AM, Smith DW, 'Effects of ageing on the mitochondrial genome in rat vestibular organs', Current Aging Science, 11 108-117 (2018) [C1] Background: Deterioration in vestibular function occurs with ageing and is linked to age-related falls. Sensory hair cells located in the inner ear vestibular labyrinth are critic... [more] Background: Deterioration in vestibular function occurs with ageing and is linked to age-related falls. Sensory hair cells located in the inner ear vestibular labyrinth are critical to vestibular function. Vestibular hair cells rely predominantly on oxidative phosphorylation (OXPHOS) for energy production and contain numerous mitochondria. Mitochondrial DNA (mtDNA) mutations and perturbed energy production are associated with the ageing process. Objective: We investigated the effects of ageing on mtDNA in vestibular hair and support cells, and vestibular organ gene expression, to better understand mechanisms of age-related vestibular deficits. Methods: Vestibular hair and supporting cell layers were microdissected from young and old rats, and mtDNA was quantified by qPCR. Additionally, vestibular organ gene expression was analysed by microarray and gene set enrichment analyses. Results: In contrast to most other studies, we found no evidence of age-related mtDNA deletion mutations. However, we found an increase in abundance of major arc genes near the mtDNA control region. There was also a marked age-related reduction in mtDNA copy number in both cell types. Vestibular organ gene expression, gene set enrichment analysis showed the OXPHOS pathway was down regulated in old animals. Conclusion: Given the importance of mtDNA to mitochondrial OXPHOS and hair cell function, our findings suggest the vestibular organs are potentially on the brink of an energy crisis in old animals.
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2018 |
Feron K, Lim R, Sherwood C, Keynes A, Brichta A, Dastoor PC, 'Organic Bioelectronics: Materials and Biocompatibility.', International Journal of Molecular Sciences, 19 (2018) [C1]
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2017 |
Wellings TP, Brichta AM, Lim R, 'Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson s disease', Experimental Brain Research, 235 3695-3708 (2017) [C1]
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2017 |
Farrell KE, Keely S, Walker MM, Brichta AM, Graham BA, Callister RJ, 'Altered intrinsic and synaptic properties of lumbosacral dorsal horn neurons in a mouse model of colitis', Neuroscience, 362 152-167 (2017) [C1] Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after vis... [more] Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation are unknown. However, clinical and pre-clinical evidence suggests plasticity within the spinal cord dorsal horn is a contributing factor. Here we use an in vivo preparation and patch-clamp electrophysiology to test whether the synaptic and intrinsic properties of superficial dorsal horn (SDH) neurons are altered 5 days after the induction of mild colitis in adult male mice (i.e. during acute inflammation of the colon). Whole-cell recordings were made from lumbosacral (L6-S1) superficial dorsal horn neurons (SDH), in animals under isoflurane anesthesia. Noxious colorectal distension (CRD) was used to identify SDH neurons with colonic inputs, while stimulation of the hind paw and tail was employed to assess convergent cutaneous input. Following inflammation, a significantly increased proportion of SDH neurons received both colonic and cutaneous inputs, compared to neurons in naïve animals. In addition, the nature and magnitude of responses to CRD and cutaneous stimulation differed in inflamed animals, as was spontaneous excitatory synaptic drive. Conversely, several measures of intrinsic excitability were altered in a manner that would decrease SDH network excitability following colitis. We propose that during inflammation, sensitization of colonic afferents results in increased signaling to the SDH. This is accompanied by plasticity in SDH neurons whereby their intrinsic properties are changed to compensate for altered afferent activity.
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2017 |
Khan SI, Hübner PP, Brichta AM, Smith DW, Migliaccio AA, 'Aging reduces the high-frequency and short-term adaptation of the vestibulo-ocular reflex in mice', Neurobiology of Aging, 51 122-131 (2017) [C1] Prevailing evidence indicates a relatively late life decline in human vestibulo-ocular reflex (VOR) function. Although mice are commonly used in mechanistic studies of vestibular ... [more] Prevailing evidence indicates a relatively late life decline in human vestibulo-ocular reflex (VOR) function. Although mice are commonly used in mechanistic studies of vestibular function, it remains unclear whether aging produces a corresponding decline in VOR function in mice. We sought to determine how the baseline VOR and its short-term adaptation were affected by aging. We tested 8 young (3-month old) and 8 aged (30-month old¿equivalent to a ~80-year old human) C57BL/6 mice. We measured their VOR response to whole-body static tilts and during 0.1¿10¿Hz whole-body sinusoidal and transient rotations before and after VOR adaptation training. Our data revealed minimal differences in static counter-tilt response between young and aged mice, but a significant deficit in baseline VOR gain in aged mice during transient rotations. Moreover, aged mice had a significant decrease in short-term VOR adaptation, particularly for training that sought to decrease the VOR response.
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2017 |
Tu L, Poppi L, Rudd J, Cresswell ET, Smith DW, Brichta A, Nalivaiko E, 'Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice', Physiology and Behavior, 174 114-119 (2017) [C1] Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the eff... [more] Hypothermic responses accompany motion sickness in humans and can be elicited by provocative motion in rats. We aimed to determine the potential role in these responses of the efferent cholinergic vestibular innervation. To this end, we used knockout (KO) mice lacking a9 cholinoreceptor subunit predominantly expressed in the vestibular hair cells and CBA strain as a wild-type (WT) control. In WT mice, circular horizontal motion (1¿Hz, 4¿cm radius, 20¿min) caused rapid and dramatic falls in core body temperature and surface head temperature associated with a transient rise in the tail temperature; these responses were substantially attenuated in KO mice; changes were (WT vs. KO): for the core body temperature¿-¿5.2¿±¿0.3 vs. -¿2.9¿±¿0.3¿°C; for the head skin temperature¿-¿3.3¿±¿0.2 vs. -¿1.7¿±¿0.2¿°C; for the tail skin temperature¿+¿3.9¿±¿1.1 vs¿+¿1.1¿±¿1.2¿°C. There was a close correlation in the time course of cooling the body and the surface of the head. KO mice also required 25% more time to complete a balance test. We conclude: i) that the integrity of cholinergic efferent vestibular system is essential for the full expression of motion-induced hypothermia in mice, and that the role of this system is likely facilitatory; ii) that the system is involvement in control of balance, but the involvement is not major; iii) that in mice, motion-induced body cooling is mediated via increased heat flow through vasodilated tail vasculature and (likely) via reduced thermogenesis. Our results support the idea that hypothermia is a biological correlate of a nausea-like state in animals.
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2016 |
Lim R, Brichta AM, 'Anatomical and physiological development of the human inner ear.', Hearing research, 338 9-21 (2016) [C1]
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2016 |
Tadros MA, Fuglevand AJ, Brichta AM, Callister RJ, 'Intrinsic excitability differs between murine hypoglossal and spinal motoneurons.', Journal of neurophysiology, 115 2672-2680 (2016) [C1]
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2016 |
Farrell KE, Rank MM, Keely S, Brichta AM, Graham BA, Callister RJ, 'In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord', Neuroscience, 316 13-25 (2016) [C1] Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible for ongoing pai... [more] Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible for ongoing pain are unknown, clinical and preclinical evidence suggests lumbosacral spinal cord dorsal horn neurons contribute to these symptoms. At present, we know little about the intrinsic and synaptic properties of this population of neurons in either normal or inflammed conditions. Therefore, we developed an in vivo preparation to make patch-clamp recordings from superficial dorsal horn (SDH) neurons receiving colonic inputs in naïve male mice. Recordings were made in the lumbosacral spinal cord (L6-S1) under isoflurane anesthesia. Noxious colorectal distension (CRD) was used to determine whether SDH neurons received inputs from mechanical stimulation/distension of the colon. Responses to hind paw/tail cutaneous stimulation and intrinsic and synaptic properties were also assessed, as well as action potential discharge properties. Approximately 11% of lumbosacral SDH neurons in the cohort of neurons sampled responded to CRD and a majority of these responses were subthreshold. Most CRD-responsive neurons (80%) also responded to cutaneous stimuli, compared with <50% of CRD-non-responsive neurons. Furthermore, CRD-responsive neurons had more hyperpolarized resting membrane potentials, larger rheobase currents, and reduced levels of excitatory drive, compared to CRD-non-responsive neurons. Our results demonstrate that CRD-responsive neurons can be distinguished from CRD-non-responsive neurons by several differences in their membrane properties and excitatory synaptic inputs. We also demonstrate that SDH neurons with colonic inputs show predominately subthreshold responses to CRD and exhibit a high degree of viscerosomatic convergence.
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2016 |
Rabbitt RD, Brichta AM, Tabatabaee H, Boutros PJ, Ahn JH, Della Santina CC, et al., 'Heat pulse excitability of vestibular hair cells and afferent neurons', Journal of Neurophysiology, 116 825-843 (2016) [C1] In the present study we combined electrophysiology with optical heat pulse stimuli to examine thermodynamics of membrane electrical excitability in mammalian vestibular hair cells... [more] In the present study we combined electrophysiology with optical heat pulse stimuli to examine thermodynamics of membrane electrical excitability in mammalian vestibular hair cells and afferent neurons. We recorded whole cell currents in mammalian type II vestibular hair cells using an excised preparation (mouse) and action potentials (APs) in afferent neurons in vivo (chinchilla) in response to optical heat pulses applied to the crista (¿T ¿ 0.25°C per pulse). Afferent spike trains evoked by heat pulse stimuli were diverse and included asynchronous inhibition, asynchronous excitation, and/or phase-locked APs synchronized to each infrared heat pulse. Thermal responses of membrane currents responsible for APs in ganglion neurons were strictly excitatory, with Q10 ¿ 2. In contrast, hair cells responded with a mix of excitatory and inhibitory currents. Excitatory hair cell membrane currents included a thermoelectric capacitive current proportional to the rate of temperature rise (dT/dt) and an inward conduction current driven by ¿T. An iberiotoxin-sensitive inhibitory conduction current was also evoked by ¿T, rising in <3 ms and decaying with a time constant of ~24 ms. The inhibitory component dominated whole cell currents in 50% of hair cells at -68 mV and in 67% of hair cells at -60 mV. Responses were quantified and described on the basis of first principles of thermodynamics. Results identify key molecular targets underlying heat pulse excitability in vestibular sensory organs and provide quantitative methods for rational application of optical heat pulses to examine protein biophysics and manipulate cellular excitability.
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2015 |
Tadros MA, Lim R, Hughes DI, Brichta AM, Callister RJ, 'Electrical maturation of spinal neurons in the human fetus: Comparison of ventral and dorsal horn', Journal of Neurophysiology, 114 2661-2671 (2015) [C1] The spinal cord is critical for modifying and relaying sensory information to, and motor commands from, higher centers in the central nervous system to initiate and maintain conte... [more] The spinal cord is critical for modifying and relaying sensory information to, and motor commands from, higher centers in the central nervous system to initiate and maintain contextually relevant locomotor responses. Our understanding of how spinal sensorimotor circuits are established during in utero development is based largely on studies in rodents. In contrast, there is little functional data on the development of sensory and motor systems in humans. Here, we use patch-clamp electrophysiology to examine the development of neuronal excitability in human fetal spinal cords (10¿18 wk gestation; WG). Transverse spinal cord slices (300 µm thick) were prepared, and recordings were made, from visualized neurons in either the ventral (VH) or dorsal horn (DH) at 32°C. Action potentials (APs) could be elicited in VH neurons throughout the period examined, but only after 16 WG in DH neurons. At this age, VH neurons discharged multiple APs, whereas most DH neurons discharged single APs. In addition, at 16¿18 WG, VH neurons also displayed larger AP and after-hyperpolarization amplitudes than DH neurons. Between 10 and 18 WG, the intrinsic properties of VH neurons changed markedly, with input resistance decreasing and AP and after-hyperpolarization amplitudes increasing. These findings are consistent with the hypothesis that VH motor circuitry matures more rapidly than the DH circuits that are involved in processing tactile and nociceptive information.
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2015 |
Tadros MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons', Molecular Pain, 11 (2015) [C1] Background: Superficial dorsal horn (SDH) neurons process nociceptive information and their excitability is partly determined by the properties of voltage-gated sodium channels. R... [more] Background: Superficial dorsal horn (SDH) neurons process nociceptive information and their excitability is partly determined by the properties of voltage-gated sodium channels. Recently, we showed the excitability and action potential properties of mouse SDH neurons change markedly during early postnatal development. Here we compare sodium currents generated in neonate (P0-5) and young adult (=P21) SDH neurons. Results: Whole cell recordings were obtained from lumbar SDH neurons in transverse spinal cord slices (CsF internal, 32°C). Fast activating and inactivating TTX-sensitive inward currents were evoked by depolarization from a holding potential of 100mV. Poorly clamped currents, based on a deflection in the IV relationship at potentials between 60 and 50mV, were not accepted for analysis. Current density and decay time increased significantly between the first and third weeks of postnatal development, whereas time to peak was similar at both ages. This was accompanied by more subtle changes in activation range and steady state inactivation. Recovery from inactivation was slower and TTX-sensitivity was reduced in young adult neurons. Conclusions: Our study suggests sodium channel expression changes markedly during early postnatal development in mouse SDH neurons. The methods employed in this study can now be applied to future investigations of spinal cord sodium channel plasticity in murine pain models.
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2015 |
Rancz EA, Moya J, Drawitsch F, Brichta AM, Canals S, Margrie TW, 'Widespread Vestibular Activation of the Rodent Cortex', JOURNAL OF NEUROSCIENCE, 35 5926-5934 (2015) [C1]
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2014 |
Tadros MA, Farrell KE, Schofield PR, Brichta AM, Graham BA, Fuglevand AJ, Callister RJ, 'Intrinsic and synaptic homeostatic plasticity in motoneurons from mice with glycine receptor mutations', Journal of Neurophysiology, 111 1487-1498 (2014) [C1] Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in t... [more] Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in three murine mutants with distinct naturally occurring mutations in the glycine receptor (GlyR), leads to intrinsic and/or synaptic homeostatic plasticity. Whole cell recordings were obtained from HMs in transverse brainstem slices from wild-type (wt), spasmodic (spd), spastic (spa), and oscillator (ot) mice (C57Bl/6, approximately postnatal day 21). Passive and action potential (AP) properties in spd and ot HMs were similar to wt. In contrast, spa HMs had lower input resistances, more depolarized resting membrane potentials, higher rheobase currents, smaller AP amplitudes, and slower afterhyperpolarization current decay times. The excitability of HMs, assessed by "gain" in injected current/firing-frequency plots, was similar in all strains whereas the incidence of rebound spiking was increased in spd. The difference between recruitment and derecruitment current (i.e., ¿I) for AP discharge during ramp current injection was more negative in spa and ot. GABAA miniature inhibitory postsynaptic current (mIPSC) amplitude was increased in spa and ot but not spd, suggesting diminished glycinergic drive leads to compensatory adjustments in the other major fast inhibitory synaptic transmitter system in these mutants. Overall, our data suggest long-term reduction in glycinergic drive to HMs results in changes in intrinsic and synaptic properties that are consistent with homeostatic plasticity in spa and ot but not in spd. We propose such plasticity is an attempt to stabilize HM output, which succeeds in spa but fails in ot. © 2014 the American Physiological Society.
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2014 |
Lim R, Drury HR, Tadros MA, Callister RJ, Brichta AM, Camp AJ, 'Preliminary Characterization of Voltage-Activated Whole-Cell Currents in Developing Human Vestibular Hair Cells and Calyx Afferent Terminals', Journal of the Association for Research in Otolaryngology, (2014) [C1] We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hai... [more] We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hair cells or calyx terminals in semi-intact cristae prepared from human fetuses aged between 11 and 18 weeks gestation (WG). During early fetal development (11-14 WG), hair cells expressed whole-cell conductances that were qualitatively similar but quantitatively smaller than those observed previously in mature rodent type II hair cells. As development progressed (15-18 WG), peak outward conductances increased in putative type II hair cells but did not reach amplitudes observed in adult human hair cells. Type I hair cells express a specific low-voltage activating conductance, G. A similar current was first observed at 15 WG but remained relatively small, even at 18 WG. The presence of a "collapsing" tail current indicates a maturing type I hair cell phenotype and suggests the presence of a surrounding calyx afferent terminal. We were also able to record from calyx afferent terminals in 15-18 WG cristae. In voltage clamp, these terminals exhibited fast inactivating inward as well as slower outward conductances, and in current clamp, discharged a single action potential during depolarizing steps. Together, these data suggest the major functional characteristics of type I and type II hair cells and calyx terminals are present by 18 WG. Our study also describes a new preparation for the functional investigation of key events that occur during maturation of human vestibular organs. © 2014 The Author(s).
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2013 |
Tung VWK, Di Marco S, Lim R, Brichta AM, Camp AJ, 'An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy', Journal of Visualized Experiments, (2013) [C1]
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2013 |
Hübner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Horizontal Vestibulo-ocular Reflex: a Study on the SPD1J Mouse', Journal of the Association for Research in Otolaryngology, 14 249-259 (2013) [C1]
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2012 |
Tadros MA, Harris B, Anderson WB, Brichta AM, Graham BA, Callister RJ, 'Are all spinal segments equal: Intrinsic membrane properties of superficial dorsal horn neurons in the developing and mature mouse spinal cord', Journal of Physiology, 590 2409-2425 (2012) [C1]
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2012 |
De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1]
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2011 |
De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1]
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2011 |
Lim R, McPherson AE, Donne SW, Callister RJ, Brichta AM, 'Potassium accumulation between type I hair cells and calyx terminals in mouse crista', Experimental Brain Research, 210 607-621 (2011) [C1]
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2011 |
Flynn JR, Brichta AM, Galea MP, Callister RJ, Graham BA, 'A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord', Journal of Neuroscience Methods, 200 113-120 (2011) [C1]
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2010 |
Jobling P, Graham BA, Brichta AM, Callister RJ, 'Cervix stimulation evokes predominantly subthreshold synaptic responses in mouse thoracolumbar and lumbosacral superficial dorsal horn neurons', Journal of Sexual Medicine, 7 2068-2076 (2010) [C1]
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2010 |
Lim R, Callister RJ, Brichta AM, 'An increase in glycinergic quantal amplitude and frequency during early vestibular compensation in mouse', Journal of Neurophysiology, 103 16-24 (2010) [C1]
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2010 |
De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
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2010 |
Camp AJ, Lim R, Anderson WB, Schofield PR, Callister RJ, Brichta AM, 'Attenuated glycine receptor function reduces excitability of mouse medial vestibular nucleus neurons', Neuroscience, 170 348-360 (2010) [C1]
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2010 |
De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Pacemaker currents in mouse locus coeruleus neurons', Neuroscience, 170 166-177 (2010) [C1]
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2009 |
Anderson WB, Graham BA, Beveridge NJ, Tooney PA, Brichta AM, Callister RJ, 'Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons', Molecular Pain, 5 1-16 (2009) [C1]
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2009 |
Tadros MA, Graham BA, Brichta AM, Callister RJ, 'Evidence for a critical period in the development of excitability and potassium currents in mouse lumbar superficial dorsal horn neurons', Journal of Neurophysiology, 101 1800-1812 (2009) [C1]
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2008 |
Graham BA, Brichta AM, Callister RJ, 'Recording temperature affects the excitability of mouse superficial dorsal horn neurons, in vitro', Journal of Neurophysiology, 99 2048-2059 (2008) [C1]
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2007 |
Graham BA, Brichta AM, Callister RJ, 'Moving from an averaged to specific view of spinal cord pain processing circuits', Journal of Neurophysiology, 98 1057-1063 (2007) [C1]
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2007 |
Graham BA, Brichta AM, Callister RJ, 'Pinch-current injection defines two discharge profiles in mouse superficial dorsal horn neurones, in vitro', Journal of Physiology, 578 787-798 (2007) [C1]
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2007 |
Graham BA, Brichta AM, Schofield PR, Callister RJ, 'Altered potassium channel function in the superficial dorsal horn of the spastic mouse', Journal of Physiology, 584 121-136 (2007) [C1]
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2006 |
Holt JC, Xue J-T, Brichta AM, Goldberg JM, 'Transmission between type II hair cells and bouton afferents in the turtle posterior crista', Journal of Neurophysiology, 95 428-452 (2006) [C1]
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2006 |
Camp AJ, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission differs in mouse type A and B medial vestibular nucleus neurons in vitro', Journal of Neurophysiology, 95 3208-3218 (2006) [C1]
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2005 |
Lee HY, Camp AJ, Callister RJ, Brichta AM, 'Vestibular primary afferent activity in an in vitro preparation of the mouse inner ear', Journal of Neuroscience Methods, 145 73-87 (2005) [C1]
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2004 |
Graham BA, Brichta AM, Callister RJ, 'In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation', Journal of Physiology, 561.3 749-763 (2004) [C1]
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2004 |
Graham BA, Brichta AM, Callister RJ, 'An in vivo mouse spinal cord preparation for patch-clamp analysis of nociceptive processing', Journal of Neuroscience Methods, 136 221-228 (2004) [C1]
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2002 |
Camp AJ, Lee H, Callister RJ, Brichta AM, 'Afferent responses to mechanical stimulation and drug application in mouse in-vitro labyrinth', Journal of Vestibular Research, 11 175 (2002) [C3]
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2002 |
Brichta AM, Camp AJ, Lee H, Callister RJ, 'Intra-axonal recordings from canal afferents in the mouse in-vitro labyrinth', Journal of Vestibular Research, 11 177-178 (2002) [C3]
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2002 |
Brichta AM, Aubert A, Eatock RA, Goldberg JM, 'Regional analysis of whole-cell currents from hair cells of the turtle posterior crista', Journal of Neurophysiology, 88 3259-3278 (2002) [C1]
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2000 |
Brichta AM, Goldberg J, 'Morphological Identification of Physiologically Characterized Afferents Innervating the Turtle Posterior Crista', Journal of Neurophysiology, 83 No. 3 1202-1223 (2000) [C1]
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2000 |
Brichta AM, Goldberg J, 'Responses to Efferent Activation and Excitatory Response-Intensity Relations of Turtle Posterior-Crista Afferents', Journal of Neurophysiology, 83 No. 3 1224-1242 (2000) [C1]
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2000 |
Won Y-S, Brichta AM, Baroody F, Boonlayangoor S, Naclerio R, 'Bactrim reduces the inflammatory response in a murine model of acute rhinosinusitis', Rhinology, 38 68-71 (2000) [C1]
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1999 |
Basile A, Brichta AM, Harris B, Morse D, Coling D, Skolnick P, 'Dizocilpine attenuates streptomycin-induced vestibulotoxicity in rats', Neuroscience Letters, 265 71-74 (1999) [C1]
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1999 |
Callister RJ, Peterson E, Brichta AM, 'Neuromuscular strategies underlying ballistic movements', Progress in Brain Research, 123 233-243 (1999) [C1]
|
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Show 79 more journal articles |
Review (2 outputs)
Year | Citation | Altmetrics | Link | |||||
---|---|---|---|---|---|---|---|---|
2015 |
Lim R, Wellings TP, Brichta AM, 'Central Vestibular Signal Processing (2015) [D1]
|
Nova | ||||||
2014 |
Wellings TP, Brichta AM, Lim R, 'Vestibular Adaptation and Compensation (2014) [D1]
|
Nova |
Conference (59 outputs)
Year | Citation | Altmetrics | Link | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2020 |
Pan S, Welsh JS, Brichta AM, Drury HR, Stoddard JG, 'Estimating the Membrane Properties of Vestibular Type II Hair Cells using Continuous-time System Identification', IFAC PAPERSONLINE, ELECTR NETWORK (2020) [E1]
|
Nova | |||||||||
2016 |
Smith JM, Case M, Yates Z, Mayhew J, Dargan J, Brichta A, 'The Advanced Surgical Anatomy Postgraduate Training Course: Supporting the needs of junior doctors in the Hunter New England Health District', Canberra, ACT (2016)
|
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2016 |
Stoddard J, Van Eerdewijk R, Welsh J, Camp A, Brichta A, 'Using indirect inference to identify models of vestibular nerve response in an isolated inner ear', 2016 Australian Control Conference, AuCC 2016, Newcastle, NSW (2016) [E1]
|
Nova | |||||||||
2015 |
Cairns M, Geaghan MP, Cairns HM, Carroll AP, Brichta AM, 'Molecular determinants of schizophrenia-associated alteration of miRNA biogenesis', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015) [E3]
|
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2015 |
Tadros M, Lim R, Hughes D, Jobling P, Brichta A, Callister R, 'Electrical maturation of sensorimotor processing in the human foetus', JOURNAL OF NEUROCHEMISTRY, Cairns, AUSTRALIA (2015) [E3]
|
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2014 |
Lim R, Drury HR, Camp AJ, Tadros MA, Callister RJ, Brichta AM, 'Anatomical and physiological characterisation of human vestibular hair cells', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science, Buenos Aires, Argentina (2014) [E3]
|
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2014 |
Wellings TP, Graham BA, Camp AJ, Callister RJ, Brichta AM, Lim R, 'Calcium binding proteins subdivide medial vestibular nucleus neurons', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science, Buenos Aires, Argentina (2014) [E3]
|
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2014 |
Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'Cholinergic Activity of the Peripheral Efferent Vestibular System', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science, Buenos Aires, Argentina (2014) [E3]
|
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2014 |
Khan SI, Hübner PP, Smith DW, Brichta AM, Migliaccio AA, 'Ageing reduces vestibulo-ocular reflex adaptation in mice J Vestib Res', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science (2014) [E3]
|
||||||||||
2013 |
Huebner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Vestibulo-Ocular Reflex: A Study on the SPD1J Mouse', 36th Association for Research in Otolaryngology, Baltimore, MD (2013) [E3]
|
||||||||||
2013 |
Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'From the ear to the brain, and back again the Efferent Vestibular System', 4th UWS Sensory Neuroscience Symposium, Sydney (2013) [E3]
|
Nova | |||||||||
2013 |
Wellings TP, Brichta AM, Lim R, 'Revealing the functional organisation of central vestibular nuclei', Neuro-Otology Society of Australia, Melbourne (2013) [E3]
|
||||||||||
2013 |
Poppi LA, Tabatabaee H, Callister RJ, Lim R, Brichta AM, 'Efferent Vestibular System the mysterious part of the periphery', Neuro-Otology Society of Australia, Melbourne (2013) [E3]
|
Nova | |||||||||
2013 |
Bigland M, Parkinson G, Brichta AM, Smith DW, 'Evidence for mitochondrial DNA deletions in vestibular hair cells of the aged rat', Proceedings of the Australian Neuroscience Society, Melbourne (2013) [E3]
|
Nova | |||||||||
2013 |
Tadros MA, Fuglevand AJ, Brichta AM, Callister RJ, 'Electrophysiological properties of cranial and spinal motor neurons in mice', Proceedings of the Australian Neuroscience Society, Melbourne (2013) [E3]
|
Nova | |||||||||
2013 | Drawitsch F, Rancz EA, Brichta AM, Canals SG, Margrie TW, 'Widespread representation of vestibular activity in the rodent brain.', Society for Neuroscience, San Diego, California, USA (2013) [E3] | ||||||||||
2012 |
Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
|
||||||||||
2012 |
Lim R, Camp AJ, Tadros MA, Drury HR, Callister RJ, Brichta AM, 'Whole cell conductances of developing human hair cells', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
|
||||||||||
2012 |
Lim R, Callister RJ, Brichta AM, 'The other part of the ear - a 'balanced' view', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
|
||||||||||
2011 |
Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Poster Abstracts. Australian Neuroscience Society Annual Meeting, Auckland, NZ (2011) [E3]
|
||||||||||
2011 |
Graham BA, Sah P, Brichta AM, Callister RJ, Hughes DI, 'Neuroanatomical and neurochemical features of parvalbumin-expressing neurons in the mouse spinal dorsal horn', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
|
||||||||||
2010 |
Lim R, Camp AJ, Walsh M, Callister RJ, Brichta AM, 'In-vitro whole-cell conductances recorded from developing human cristae', Journal of Vestibular Research, Reykavik, Iceland (2010) [E3]
|
||||||||||
2010 |
Lim R, Stitt I, Camp AJ, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission in the lateral vestibular nucleus', Journal of Vestibular Research, Reykavik, Iceland (2010) [E3]
|
||||||||||
2010 |
Callister RJ, Walsh MA, Harris BM, Anderson WB, Brichta AM, Graham BA, 'Segmental and developmental differences in the excitability of mouse superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
|
||||||||||
2010 |
Walsh MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Sodium current properties differ in neonate and adult superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
|
||||||||||
2010 |
Harris BM, Graham BA, Bolton PS, Brichta AM, Callister RJ, 'Influence of acute neck muscle inflammation on the excitability of superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
|
||||||||||
2010 |
Graham BA, Hughes DI, Lim R, Sah P, Brichta AM, Callister RJ, 'Characterization of calretinin expressing interneurons in the superficial dorsal horn of the mouse spinal cord', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
|
||||||||||
2009 |
De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Ion channel modulation by reactive species in mice locus coeruleus neurons', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
|
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2009 |
De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Effect of antioxidants in pacemaking of mice locus coeruleus neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
|
||||||||||
2009 |
Brichta AM, Lamont E, Lim R, Callister RJ, 'Vestibular effects of endolymphatic ionic and volume changes in an isolated preparation of a mouse labyrinth', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
|
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2009 |
McPherson AE, Lim R, Callister RJ, Brichta AM, 'Voltage dependent currents in Type I and II hair cells and calyx terminals of primary afferents in an intact in vitro mouse vestibular crista preparation', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
|
||||||||||
2009 |
Lim R, Callister RJ, Brichta AM, 'Changes in glycinergic synaptic transmission and neuronal excitability in mouse medial vestibular nucleus neurons during early vestibular compensation', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
|
||||||||||
2009 |
Lim R, McPherson AE, Pow DV, Callister RJ, Brichta AM, 'Glutamate transport in the mouse inner ear is mediated by the excitatory amino acid transporter, EAAT5', Abstracts of the Thirty-Second Annual Midwinter Research Meeting Association for Research in Otolaryngology, Baltimore, MD (2009) [E3]
|
||||||||||
2008 |
Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch clamp recording of synaptic events evoked in superficial dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
|
Nova | |||||||||
2008 |
De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Influence of mitochondria in the interspike interval pacemaking currents of mice Locus Coeruleus neurons', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
|
||||||||||
2008 |
Callister RJ, Brichta AM, Graham BA, 'Beyond the dorsal horn: The use of animal models to discover new sites for pain therapy', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
|
||||||||||
2007 |
Camp AJ, Anderson WB, Callister RJ, Schofield PR, Brichta AM, 'Contribution of inhibitory synaptic transmission to the intrinsic membrane properties of Medial Vestibular Nucleus (MVN) neurons (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
|
||||||||||
2006 |
Anderson WB, Graham BA, Jobling P, Lim R, Brichta AM, Callister RJ, 'Glycine receptor diversity in the dorsal horn of the mouse spinal cord', Society for Neuroscience, Atlanta, GA (2006) [E3]
|
||||||||||
2006 |
Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch-clamp recording of subthreshold synaptic events evoked in dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Society for Neuroscience, Atlanta, Georgia (2006) [E3]
|
||||||||||
2006 |
Walsh MA, Graham BA, Brichta AM, Callister RJ, 'Postnatal development of electrophysiological properties in mouse supeficial dorsal horn neurones', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
|
||||||||||
2005 |
Graham BA, Brichta AM, Callister RJ, 'Effect of Temperature on the Discharge Properties of Mouse Superficial Dorsal Horn Neurons', Proceedings of the Australian Neuroscience Society, Perth (2005) [E3]
|
||||||||||
2005 |
Camp AJ, Watson PJ, Schofield PR, Callister RJ, Brichta AM, 'Inhibitory Synaptic Transmission in Medial Vestibular Nucleus Neurons of Wildtype, Spastic, Spasmodic, and Oscillator Mice', Proceedings of the Australian Neuroscience Society, Perth (2005) [E3]
|
||||||||||
2005 |
Callister RJ, Graham BA, Brichta AM, 'In Vivo Responses of Mouse Spinal Neurones to Electrical and Functionally-Relevant Stimulation', Proceedings of the Australian Neuroscience Society Conference, Perth (2005) [E3]
|
||||||||||
2004 |
Krajniak SG, Callister RJ, Imtiaz MS, Brichta AM, Van Helden DF, 'Investigation of a brain rhythm', Proceedings of the Australian Neuroscience Society, Australia (2004) [E3]
|
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2001 |
Lee H-Y, Callister RJ, Brichta AM, 'Morphophysiology of Vestibular Afferents Recorded from an In Vitro Preparation of the Mouse Inner Ear', Abstracts of the Twenty-Fourth Annual Midwinter Research Meeting of the Association for Research in Otolaryngology, U.S.A. (2001) [C3]
|
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2001 |
Lee H-Y, Callister RJ, Brichta AM, 'Physiology of Labelled Vestibular Afferents Recorded from an In Vitro Preparation of the Mouse Inner Ear', Proceedings of the Australian Neuroscience Society, Australia (2001) [C3]
|
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1999 | Brichta AM, Goldberg J, 'Ionic Currents of Isolated Hair Cells Selectively Harvested from Different Zones of the Turtle Posterior Crista', Proceedings of the Australian Neuroscience Society. Vol. 10, University of Tasmania, Hobart, Tasmania. (1999) [E2] | ||||||||||
Show 56 more conferences |
Presentation (2 outputs)
Year | Citation | Altmetrics | Link | ||
---|---|---|---|---|---|
2019 |
Liebenberg A, 'The prevalence of hearing loss: Pre-employment audiograms in NSW Coal Mining', (2019)
|
||||
2017 |
Liebenberg A, James C, Brichta A, Nie V, 'Audiometric profiles: NSW Coal Mine workers 1991 - 2015', (2017)
|
Grants and Funding
Summary
Number of grants | 67 |
---|---|
Total funding | $9,860,310 |
Click on a grant title below to expand the full details for that specific grant.
20232 grants / $182,663
Organic Bioelectronics: Solving Key Barriers to Precision Neuromodulation$142,663
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Paul Dastoor, Professor Alan Brichta, Dr Matthew Griffith, Associate Professor Rebecca Lim |
Scheme | Discovery Projects |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2025 |
GNo | G2300070 |
Type Of Funding | C1200 - Aust Competitive - ARC |
Category | 1200 |
UON | Y |
Specific targeting of proNGF, p75NTR, and sortilin for the treatment of acoustic neuroma$40,000
Funding body: Brain Foundation (NSW Branch)
Funding body | Brain Foundation (NSW Branch) |
---|---|
Project Team | Associate Professor Rebecca Lim, Professor Alan Brichta, Associate Professor Robert Eisenberg, Professor Hubert Hondermarck, Associate Professor Phil Jobling |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | G2200681 |
Type Of Funding | C1700 - Aust Competitive - Other |
Category | 1700 |
UON | Y |
20223 grants / $510,347
BioSHeM: A High-Resolution Imaging and Spectroscopic Helium Atom Microscope$420,347
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Paul Dastoor, Laureate Professor Roger Smith, Professor Alan Brichta, Professor Chris Dayas, Associate Professor Ian Grainge, Jamie Quinton, Elizabeth Dinsdale, Prof Peter Cumpson, Jane Evans, Elizabeth Dinsdale, Jane Evans, Jamie Quinton |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | G2100336 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
BioSHeM: A High-Resolution Imaging and Spectroscopic Helium Atom Microscope$50,000
Funding body: Flinders University
Funding body | Flinders University |
---|---|
Project Team | Professor Paul Dastoor, Laureate Professor Roger Smith, Professor Alan Brichta, Professor Chris Dayas, Associate Professor Ian Grainge, Jamie Quinton, Elizabeth Dinsdale, Prof Peter Cumpson, Jane Evans, Elizabeth Dinsdale, Jane Evans, Jamie Quinton |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) Partner Funding |
Role | Investigator |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | G2201230 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
BioSHeM: A High-Resolution Imaging and Spectroscopic Helium Atom Microscope$40,000
Funding body: University of New South Wales
Funding body | University of New South Wales |
---|---|
Project Team | Professor Paul Dastoor, Laureate Professor Roger Smith, Professor Alan Brichta, Professor Chris Dayas, Associate Professor Ian Grainge, Jamie Quinton, Elizabeth Dinsdale, Prof Peter Cumpson, Jane Evans, Elizabeth Dinsdale, Jane Evans, Jamie Quinton |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) Partner Funding |
Role | Investigator |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | G2201231 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
20211 grants / $16,824
Nanoengineered Bioelectronic Systems for All-Optical Control of Neuron Growth and Stimulation$16,824
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Associate Professor Rebecca Lim, Professor Alan Brichta, Professor Paul Dastoor, Dr Natalie Holmes, Pro Julie Cairney, Dr Matthew Griffith, Mr Mitchell Bonham |
Scheme | Ideas Grants |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2024 |
GNo | G2100150 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
20201 grants / $658,262
The Efferent Vestibular System as a new target to treat balance disorders and motion sickness$658,262
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Alan Brichta, Associate Professor Eugene Nalivaiko, Associate Professor Rebecca Lim, Conjoint Professor Robert Callister, Dr Lauren Poppi, Associate Professor Joseph Holt |
Scheme | Ideas Grants |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2023 |
GNo | G1900582 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
20183 grants / $175,501
All-optical manipulation and recording of neural circuit activity$100,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Chris Dayas, Professor Alan Brichta, Professor Gavan McNally, Professor Brett Graham, McNully, Gavan |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2018 |
Funding Finish | 2018 |
GNo | G1700451 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Multi-Channel Systems: Multi-Electrode Array (MEA) System: MEA2100-60-System-E$65,761
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Associate Professor Rebecca Lim, Professor Murray Cairns, Professor Alan Brichta, Professor Xu Dong Zhang, Professor Paul Dastoor, Professor Brett Neilan |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2018 |
Funding Finish | 2018 |
GNo | G1800481 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Jennie Thomas Medical Research Travel Grant$9,740
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Miss Lauren Poppi, Professor Alan Brichta |
Scheme | Jennie Thomas Medical Research Travel Grant |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2018 |
GNo | G1800715 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
20171 grants / $21,000
The role of calcium in the Efferent Vestibular System (EVS)$21,000
Funding body: The Garnett Passe and Rodney Williams Memorial Foundation
Funding body | The Garnett Passe and Rodney Williams Memorial Foundation |
---|---|
Project Team | Professor Alan Brichta, Associate Professor Rebecca Lim |
Scheme | Grant-in-Aid (Supplementation) |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2018 |
GNo | G1700178 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
20162 grants / $517,157
Mechanisms underlying efferent feedback in the vestibular system$510,121
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Alan Brichta, Professor Brett Graham, Associate Professor Rebecca Lim, Conjoint Professor Robert Callister, Professor Chris Dayas, Dr Chris Holt, Professor Richard Rabbitt |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2019 |
GNo | G1500239 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
Improving rapid decisions made under duress$7,036
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Scott Brown, Professor Ami Eidels, Doctor Keith Nesbitt, Professor Alan Brichta |
Scheme | Linkage Pilot Research Grant |
Role | Investigator |
Funding Start | 2016 |
Funding Finish | 2018 |
GNo | G1501472 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20152 grants / $22,000
Dizzy and Deaf - restoring signals from the inner ear$20,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Associate Professor Rebecca Lim, Professor Alan Brichta, Conjoint Professor Robert Callister, Associate Professor Doug Smith |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2015 |
Funding Finish | 2015 |
GNo | G1501395 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
Association for Research in Otolaryngology, 21-25 February 2015$2,000
Funding body: University of Newcastle - Faculty of Health and Medicine
Funding body | University of Newcastle - Faculty of Health and Medicine |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2015 |
GNo | G1500257 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20143 grants / $647,772
Spinal processing of sensory signals from the gut$554,477
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Simon Keely, Professor Brett Graham, Professor Alan Brichta, Dr David Hughes |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2014 |
Funding Finish | 2017 |
GNo | G1300361 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Physiological and Behavioural Characterisation of Central Vestibular Function$91,295
Funding body: The Garnett Passe and Rodney Williams Memorial Foundation
Funding body | The Garnett Passe and Rodney Williams Memorial Foundation |
---|---|
Project Team | Dr Thomas Wellings, Professor Alan Brichta, Associate Professor Rebecca Lim |
Scheme | Research Scholarship |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2015 |
GNo | G1301066 |
Type Of Funding | C3500 – International Not-for profit |
Category | 3500 |
UON | Y |
XXVIIIth Barany Society Meeting, Buenos Aires Argentina, 25-29 May 2014$2,000
Funding body: University of Newcastle - Faculty of Health and Medicine
Funding body | University of Newcastle - Faculty of Health and Medicine |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1400597 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20135 grants / $543,370
Development of functional connections in the human peripheral vestibular system$438,370
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Associate Professor Rebecca Lim, Professor Alan Brichta, Conjoint Professor Robert Callister |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2017 |
GNo | G1200254 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Pradeep Tanwar, Professor Eileen McLaughlin, Professor Xu Dong Zhang, Conjoint Professor Robert Callister, Associate Professor Phillip Dickson, Professor Hubert Hondermarck, Doctor Jean-Marie Sontag, Professor Dirk Van Helden, Associate Professor Doug Smith, Associate Professor Phil Jobling, Associate Professor Estelle Sontag, Associate Professor Paul Tooney, Associate Professor Susan Hua, Doctor Janet Bristow, Professor Jay Horvat, Prof LIZ Milward, Professor Adam McCluskey, Professor Brett Nixon, Associate Professor Rebecca Lim, Professor Alan Brichta |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1201185 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Murray Cairns, Professor Rohan Walker, Professor Alan Brichta, Doctor Natalie Beveridge |
Scheme | Near Miss Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1300468 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Murray Cairns, Professor Rohan Walker, Professor Alan Brichta, Doctor Natalie Beveridge |
Scheme | Near Miss |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1300801 |
Type Of Funding | Grant - Aust Non Government |
Category | 3AFG |
UON | Y |
microRNA and translation dynamics of synaptic plasticity$20,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Murray Cairns, Professor Alan Brichta, Professor Rohan Walker |
Scheme | Near Miss Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1300463 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20122 grants / $479,319
Development of peripheral sensory pathways in humans$477,504
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Alan Brichta, Associate Professor Phil Jobling, Dr David Hughes |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2014 |
GNo | G1100102 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Association for Research in Otolaryngology 35th Annual Mid Winter Meeting, San Diego, 25 - 29 February 2012$1,815
Funding body: University of Newcastle - Faculty of Health and Medicine
Funding body | University of Newcastle - Faculty of Health and Medicine |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2013 |
GNo | G1200416 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20112 grants / $349,208
Efferent modulation of the vestibular periphery$339,208
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister, Associate Professor Rebecca Lim |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2011 |
Funding Finish | 2013 |
GNo | G1000315 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
IMPLEN NanoPhotometer pearl$10,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Prof ULLI Schall, Associate Professor Phillip Dickson, Professor Rohan Walker, Doctor Rick Thorne, Professor Chris Dayas, Associate Professor Nikki Verrills, Doctor Janet Bristow, Doctor Severine Roselli Dayas, Associate Professor Kathryn Skelding, Doctor Jude Weidenhofer, Prof LIZ Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Doctor Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1100030 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20106 grants / $1,129,500
Molecular and cellular characterisation of schizophrenia associated dysfunction in microRNA biogenesis$478,500
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Murray Cairns, Professor Rodney Scott, Associate Professor Paul Tooney, Emeritus Professor John Rostas, Professor Alan Brichta |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2012 |
GNo | G0190196 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Laser microdissection microscopy system for cell and development biology$350,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Distinguished Emeritus Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Aprof DAVID McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G0190369 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Laser microdissection microscopy system for cell and development biology$215,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Distinguished Emeritus Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Aprof DAVID McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000874 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Laser microdissection microscopy system for cell and development biology (HMRI contribution towards 2010 ARC LIEF grant)$50,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Distinguished Emeritus Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Aprof DAVID McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000144 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
ABI 7500 Real Time PCR System $34,000
Funding body: NHMRC (National Health & Medical Research Council)
XXVI Barany Society Meeting, Reykjavik, 15 - 21st August 2010 , $2,000
Funding body: University of Newcastle - Faculty of Health and Medicine
Funding body | University of Newcastle - Faculty of Health and Medicine |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2010 |
Funding Finish | 2011 |
GNo | G1000134 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20095 grants / $1,216,144
Electron Microscopes for Nanometer-scale Imaging/Microanalysis in the Materials, Biological, Physical, Engineering and Chemical Sciences$650,000
Funding body: ARC (Australian Research Council)
Spinal mechanisms underlying neck pain$451,500
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Philip Bolton, Professor Alan Brichta |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2011 |
GNo | G0188840 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Electron Microscopes for Nanometer-scale Imaging/Microanalysis in the Materials, Biological, Physical, Engineering and Chemical Sciences$70,000
Funding body: ARC (Australian Research Council)
Neurometer CPT/C$28,435
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Philip Bolton, Conjoint Professor Robert Callister, Professor Alan Brichta, Emeritus Professor Robin Callister, Professor Brett Graham, Associate Professor Phil Jobling |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2009 |
GNo | G0189845 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Leica VT1200S - Fully automated vibrating blade microtome$16,209
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Professor Brett Graham, Professor Philip Bolton, Associate Professor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Associate Professor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2009 |
GNo | G0189842 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20083 grants / $1,044,069
Vestibular signalling mechanisms; from periphery to brainstem$1,000,000
Funding body: The Garnett Passe and Rodney Williams Memorial Foundation
Funding body | The Garnett Passe and Rodney Williams Memorial Foundation |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Senior/Principal Research Fellowship |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2012 |
GNo | G0188205 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
Recovery of the balance system following injury$24,069
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister, Professor Philip Bolton, Associate Professor Phil Jobling, Associate Professor Rebecca Lim |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0188471 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Leica VT2100S Vibrating Microtome$20,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister, Professor Dirk Van Helden, Professor Philip Bolton, Associate Professor Rebecca Lim, Professor Brett Graham, Dr Marcus Howlett, Doctor Angela McPherson, Doctor Mohammad Imtiaz, Doctor Ramatis De Oliveira, Mr Wayne Anderson, Mr Matthew Walsh |
Scheme | Equipment Grant |
Role | Lead |
Funding Start | 2008 |
Funding Finish | 2008 |
GNo | G0188540 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20072 grants / $37,678
High speed/sensitivity CCD camera$30,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Conjoint Professor Robert Callister, Professor Brett Graham, Professor Derek Laver, Prof LIZ Milward, Associate Professor John Holdsworth |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0188196 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Developing a rodent model to study neck pain$7,678
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Philip Bolton, Professor Alan Brichta, Professor Brett Graham |
Scheme | Pilot Grant |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0187879 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20064 grants / $1,011,402
Descending control of pain pathways$423,950
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Trevor Day, Professor Alan Brichta |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2006 |
Funding Finish | 2008 |
GNo | G0185184 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
The neural basis of vestibular compensation$311,472
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2006 |
Funding Finish | 2008 |
GNo | G0185195 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Cellular mechanisms underlying activity in the peripheral vestibular organs$269,980
Funding body: The Garnett Passe and Rodney Williams Memorial Foundation
Funding body | The Garnett Passe and Rodney Williams Memorial Foundation |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2006 |
Funding Finish | 2008 |
GNo | G0185817 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
Endolymphatic changes in isolated inner ear$6,000
Funding body: Sydney University Medical Foundation
Funding body | Sydney University Medical Foundation |
---|---|
Project Team | Alan Brichta |
Scheme | Meniere's Disease Foundation |
Role | Lead |
Funding Start | 2006 |
Funding Finish | 2006 |
GNo | |
Type Of Funding | External |
Category | EXTE |
UON | N |
20053 grants / $243,000
INVESTIGATION OF A BRAIN RHYTHM$220,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Dirk Van Helden, Conjoint Professor Robert Callister, Professor Alan Brichta |
Scheme | Discovery Projects |
Role | Investigator |
Funding Start | 2005 |
Funding Finish | 2007 |
GNo | G0184333 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Novel spinal cord targets for pain management$13,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Alan Brichta |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2005 |
Funding Finish | 2005 |
GNo | G0184884 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Descending control of pain processing pathways in the spinal cord$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Conjoint Professor Robert Callister, Professor Alan Brichta, Professor Trevor Day |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2005 |
Funding Finish | 2005 |
GNo | G0184748 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20045 grants / $336,047
High-Speed Confocal Microscope Live Cell Recording System$274,692
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Dirk Van Helden, Distinguished Emeritus Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0183031 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
High-speed Confocal Microscope Live Cell Recording System$30,000
Funding body: University of New South Wales
Funding body | University of New South Wales |
---|---|
Project Team | Professor Dirk Van Helden, Associate Professor J Keast, Distinguished Emeritus Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) Partner Funding |
Role | Investigator |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0183841 |
Type Of Funding | Not Known |
Category | UNKN |
UON | Y |
How does the balance system process signals?$14,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0183499 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Investigation a brain rythym$14,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Dirk Van Helden, Conjoint Professor Robert Callister, Professor Alan Brichta |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0184506 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Annual Meeting of the Society for Neuroscience, 23-27 October 2004, USA$2,355
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0184863 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20032 grants / $67,353
Transduction mechanisms in the in vitro mouse vestibular organs.$51,018
Funding body: The Garnett Passe and Rodney Williams Memorial Foundation
Funding body | The Garnett Passe and Rodney Williams Memorial Foundation |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Postgraduate Research Scholarship |
Role | Lead |
Funding Start | 2003 |
Funding Finish | 2004 |
GNo | G0182512 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
Equipment Grant$16,335
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Robert Callister |
Scheme | RIB Grant |
Role | Investigator |
Funding Start | 2003 |
Funding Finish | 2003 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20022 grants / $339,500
Electron Microscope/X-Ray Unit Equipment Upgrade$337,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Conjoint Professor Christina Offler, Prof BILL Collins, Professor Erich Kisi, Professor Alan Brichta, Distinguished Emeritus Professor John Aitken, Emeritus Professor John Patrick |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2002 |
Funding Finish | 2002 |
GNo | G0181515 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Biennial Conference: Barany Society XXII Meeting and Satellite Meeting Seattle, Washington State, USA, 22-29 September 2002$2,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2002 |
Funding Finish | 2002 |
GNo | G0182225 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20012 grants / $24,042
Efferent modulation of hearing and the sense of balance$20,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2001 |
Funding Finish | 2001 |
GNo | G0181165 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Investigation of the efferent vestibular system in a mammalian in vitro preparation.$4,042
Funding body: The Garnett Passe and Rodney Williams Memorial Foundation
Funding body | The Garnett Passe and Rodney Williams Memorial Foundation |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2001 |
Funding Finish | 2001 |
GNo | G0180499 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
20003 grants / $232,311
Cellular mechanisms underlying the sense of balance.$190,020
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2000 |
Funding Finish | 2002 |
GNo | G0178493 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Cellular Mechanisms Underlying the Sense of Balance.$30,291
Funding body: The Garnett Passe and Rodney Williams Memorial Foundation
Funding body | The Garnett Passe and Rodney Williams Memorial Foundation |
---|---|
Project Team | Professor Alan Brichta, Conjoint Professor Robert Callister |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2000 |
Funding Finish | 2000 |
GNo | G0179041 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
Cellular Mechanisms Underlying the Sense of Balance.$12,000
Funding body: Ramaciotti Foundations
Funding body | Ramaciotti Foundations |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2000 |
Funding Finish | 2000 |
GNo | G0178720 |
Type Of Funding | Aust Competitive - Non Commonwealth |
Category | 1NS |
UON | Y |
19991 grants / $11,000
Cellular mechanisms underlying the sense of balance.$11,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Internal Research Support |
Role | Lead |
Funding Start | 1999 |
Funding Finish | 1999 |
GNo | G0179151 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
19981 grants / $17,000
Cellular mechanisms underlying the sense of balance$17,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Alan Brichta |
Scheme | New Staff Grant |
Role | Lead |
Funding Start | 1998 |
Funding Finish | 1998 |
GNo | G0180943 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
1 grants / $27,841
Two replacement OBIS lasers for Nikon Eclipse 80i Confocal microscope (488 nm and 594 nm)$27,841
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Alan Brichta |
Scheme | Equipment Grant |
Role | Lead |
Funding Start | |
Funding Finish | |
GNo | G1301305 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2020 | PhD | Organic Bioelectronics: Nerve Cell Guidance and Regeneration | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2024 | PhD | Structure and Function of the Efferent Vestibular System | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2023 | PhD | Photostimulation of Neurons Using Organic Bioelectronics | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2021 | PhD | Identification of the NR2C Subtype of the N-Methyl-D-Aspartate Receptor (NMDAR) as a Potential Molecular Target for Melanoma Treatment | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | The Role of Protein Phosphatase 2A in Alzheimer’s Disease Pathogenesis | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | Ageing of the Inner Ear Vestibular Organs | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | Characterising Transcriptional Perturbations Arising from Altered Expression of Schizophrenia-Associated MicroRNA | PhD (Medical Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2018 | PhD | Synaptic Properties of the Mammalian Peripheral Efferent Vestibular System | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2018 | PhD | Anatomical and Physiological Characterisation of Central Vestibular Neuronal Populations | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2011 | PhD | Electrophysiological Development of Superficial Dorsal Horn Neurons in Mice | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2010 | PhD | Pacemaking in Mouse Locus Coeruleus Neurons: Electrophysiological Properties, Role of Mitochondria and Development | PhD (Human Physiology), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2007 | PhD | Inhibitory Synaptic Transmission in Mouse Medial Vestibular Nucleus Neurons | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Principal Supervisor |
2006 | PhD | The Excitability of Pain Processing Neurons Studied in the Mouse Spinal Cord in Vivo and in Vitro | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
Research Collaborations
The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.
Country | Count of Publications | |
---|---|---|
Australia | 71 | |
United States | 33 | |
United Kingdom | 4 | |
Netherlands | 3 | |
Canada | 2 | |
More... |
News
News • 18 Dec 2019
NHMRC awards $9.3 million to 13 University of Newcastle projects
The University of Newcastle has received more than $9.3 million in funding to support projects aiming to solve some of the world’s most critical health problems and improve the lives of millions of Australians.
News • 13 Nov 2015
NHMRC funding success 2016
Professor Alan Brichta has been awarded more than $491,000 in NHMRC Project Grant funding commencing in 2016 for his research project Mechanisms underlying efferent feedback in the vestibular system.
News • 20 Mar 2015
Keeping Newcastle balanced: balance research in vestibular neuroscience
How do we understand the world around us? A seemingly simple question.
Professor Alan Brichta
Positions
Professor
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Casual Lecturer
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Focus area
Anatomy
Contact Details
alan.brichta@newcastle.edu.au | |
Phone | (02) 4921 7026 |
Fax | (02) 4921 7812 |
Link | UoN Blogs |
Office
Room | MS309A |
---|---|
Building | Medical Sciences |
Location | Callaghan University Drive Callaghan, NSW 2308 Australia |