Professor Dirk Van Helden

Professor

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Investigations are being made on cellular rhythms including those in lymphatics, blood vessels, gastrointestinal tract, heart and specific mood-associated brain nuclei. We have discovered a new mechanism that it is driven by intracellular Ca2+ stores that allow groups of cells to self pace and hence become rhythmic. We are now exploring the relevance of this mechanism in a range of tissues. We are also interested in specific proteins involved in the pacemaker mechanism including inositol 1,4,5-trisphosphate receptors, ryanodine receptors, store operated calcium channels and TRP family proteins. These studies may influence future therapies to control lymphedema, digestive disorders, heart arrhythmias and brain mood states. We also have a recent patent relating to use of a topical ointment as a first aid treatment against snakebite. This was a surprising outcome that arose from studies investigating whether snake venoms enhance lymphatic pumping and hence accelerate their own delivery. Our preliminary trials indicate topical application of the ointment slows lymphatic transport by some 350% with no obvious adverse effects. The cream will be of particular use for bites to the torso where pressure bandaging is ineffective. It may also be useful as a first aid treatment against bites from other venomous creatures.

Research Expertise
Lymphatic and gastric pacemaking: Pacemaking in the lymphatic and gastric systems are the basis for our discovery of store pacemaking and calcium phase waves. We are now unravelling the finer details of these mechanisms. Importantly, as for all good research, there can often be unexpected yet important serendipitous outcomes. One in case is that this work has led to development of a first aid treatment against bites from venomous animals whose venoms transit the lymphatic system and we have a patent application on this finding under review. Heart pacemaking: Traditionally, this has been considered to operate through a clock in the cell surface membrane of pacemaker cells. However, recent evidence from our pilot and modelling studies and from the work of others indicates a significant role of calcium stores. This introduces the possibility that the heart pacemaker model is only part of the story and that pacemaking involves an intracellular clock (i.e. store pacemaking). We are investigating this hypothesis, which if upheld will change the text book model for heart pacemaking and help change present understanding of specific heart disorders and their treatment. (National Health and Medical Research Program Grant -NHMRC PG Cardiac Pacemaking, 2007-2009). Brain rhythms: Brain rhythms function in most areas of the brain and while fundamental to life and our psyche remain poorly understood. We are testing the hypothesis that specific rhythms in the Locus Coeruleus, a brain stem nucleus known to be associated with mood states, are generated by store pacemaking. Evidence that the rhythms are generated by store pacemaking could provide a new framework for interpreting drug action in the treatment of mood disorders such as Bipolar Disorder. (Australian Research Council Discovery Program Grant Investigation of a Brain Rhythm 2005-2007). Uterine pacemaking: Astonishingly, there is still no clear understanding of the pacemaker mechanism that initiates and times uterine contractions. Pilot studies we have undertaken suggest this to be mediated by store pacemaking. Proof for this hypothesis would herald a mechanistic description for uterine contractions and may provide new insight into associated dysfunctions such as premature birth. (NHMRC PG Rhythmicity and synchronicity in uterine smooth muscle, 2007-2009).

Teaching Expertise
Honours and Postgraduate students

Administrative Expertise
Research policy (e.g. Archetect of the Brawn Fellowship Scheme at the University of Newcastle)

Collaborations
Research Collaborations are being undertaken into: 1) Mechanisms underlying heart pacemaking with A/Prof Derek Laver, Prof Mark Boyett (Manchester University) and Prof Derek Terrar (Oxford University); 2) Gastrointestinal function Prof Hikaru Hashitani (Nagoya City University, Japan), Dr Bridget Southwell (Murdoch Children's Hospital) & Dr Costa Karihaloo (Lake Macquarrie Private Hospital); 3) Lymphatic function in health and disease ( Dr Mohammad Imtiaz and A/Prof Pierre Yves von der Weid (Calgary, Canada); 4) Spontaneous activity of the Locus coeruleus, a brain cell nucleus involved in establishement of attention and mood states (Dr Ramatis de Oliveira (Brazil), A/Prof Alan Brichta, Prof Robert Callister, Dr Rebecca Lim, Prof Janusz Lipski (Auckland), Mr Andrew Yee (Auckland).

Qualifications

  • PhD, University of New South Wales
  • Bachelor of Engineering, University of New South Wales

Keywords

  • Cellular physiologist
  • gastrointestinal physiology
  • heart pacemaking
  • neuroscience
  • smooth muscle

Fields of Research

Code Description Percentage
020599 Optical Physics not elsewhere classified 10
110399 Clinical Sciences not elsewhere classified 30
111699 Medical Physiology not elsewhere classified 60

Professional Experience

UON Appointment

Title Organisation / Department
Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2001 -  NHMRC Principal Research Fellow & Brawn Senior Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2001 - 1/12/2011 Fellow NHMRC

NHMRC - Research Fellowships Scheme

University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1997 -  Senior Brawn Fellowship

University of Newcastle - Gladys M. Brawn Fellowship Scheme

University of Newcastle
Australia
1/01/1990 - 1/12/2000 NHMRC Senior Research Fellow

NHMRC - Research Fellowships Scheme

University of Newcastle
Australia

Membership

Dates Title Organisation / Department
Member - Australian Physiological Society Australian Physiological Society
Australia
Member - The British Journal of Pharmacology Wiley Online Library
Australia
Chair of the Research Committee - Cardiovascular Group Hunter Medical Research Institute (HMRI)
Australia
Faculty Member - Cardiovascular Physiology/Circulation of 'Faculty of 1000 Biology' Faculty of 1000
Australia
Member of Council - Australian Physiological Society Australian Physiological Society
Australia
1/01/2001 - 31/12/2005 Member of Editorial Board - the British Journal of Pharmacology Wiley Online Library
Australia

Awards

Honours

Year Award
2012 Honorary Member
Unknown
2007 Sparke Helmore
Hunter Medical Research Institute

Recognition

Year Award
2013 Adjunct Professor
Unknown

Invitations

External Reviewer - Departments

Year Title / Rationale
2005 Department of physiology
Organisation: University of Western Australia Description: Review RQF of the department for future planning

Participant

Year Title / Rationale
2005 calcium signaling
Organisation: Gordon conference Description: Invited speaker
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (104 outputs)

Year Citation Altmetrics Link
2015 Nikolaev YA, Dosen PJ, Laver DR, Van Helden DF, Hamill OP, 'Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons', Brain Research, 1608 1-13 (2015)

The mammalian brain is a mechanosensitive organ that responds to different mechanical forces ranging from intrinsic forces implicated in brain morphogenesis to extrinsic forces th... [more]

The mammalian brain is a mechanosensitive organ that responds to different mechanical forces ranging from intrinsic forces implicated in brain morphogenesis to extrinsic forces that can cause concussion and traumatic brain injury. However, little is known of the mechanosensors that transduce these forces. In this study we use cell-attached patch recording to measure single mechanically-gated (MG) channel currents and their affects on spike activity in identified neurons in neonatal mouse brain slices. We demonstrate that both neocortical and hippocampal pyramidal neurons express stretch-activated MG cation channels that are activated by suctions of ~25 mm Hg, have a single channel conductance for inward current of 50-70 pS and show weak selectivity for alkali metal cations (i.e., Na+++). Significantly, single MG channel currents activated on the soma trigger spiking/action potentials in both neocortical and hippocampal pyramidal neurons. Not all neuron types studied here expressed MG channel currents. In particular, locus coeruleus and cerebellar Purkinje neurons showed no detectable MG channel activity. Moreover their robust rhythmic spike activity was resistant to mechanical modulation. Our observation that a single MG channel current can trigger spiking predicates the need for reassessment of the long held view that the impulse output of central neurons depends only upon their intrinsic voltage-gated channels and/or their integrated synaptic input.

DOI 10.1016/j.brainres.2015.02.051
Co-authors Derek Laver
2015 Zhang H-M, Imtiaz MS, Laver DR, McCurdy DW, Offler CE, Van Helden DF, Patrick JW, 'Polarized and persistent Ca2+ plumes define loci for formation of wall ingrowth papillae in transfer cells', Journal of Experimental Botany, 66 1179-1190 (2015)

Transfer cell morphology is characterized by a polarized ingrowth wall comprising a uniform wall upon which wall ingrowth papillae develop at right angles into the cytoplasm. The ... [more]

Transfer cell morphology is characterized by a polarized ingrowth wall comprising a uniform wall upon which wall ingrowth papillae develop at right angles into the cytoplasm. The hypothesis that positional information directing construction of wall ingrowth papillae is mediated by Ca2+ signals generated by spatiotemporal alterations in cytosolic Ca2+ ([Ca2+]cyt) of cells trans-differentiating to a transfer cell morphology was tested. This hypothesis was examined using Vicia faba cotyledons. On transferring cotyledons to culture, their adaxial epidermal cells synchronously trans-differentiate to epidermal transfer cells. A polarized and persistent Ca2+ signal, generated during epidermal cell trans-differentiation, was found to co-localize with the site of ingrowth wall formation. Dampening Ca2+ signal intensity, by withdrawing extracellular Ca2+ or blocking Ca2+ channel activity, inhibited formation of wall ingrowth papillae. Maintenance of Ca2+ signal polarity and persistence depended upon a rapid turnover (minutes) of cytosolic Ca2+ by co-operative functioning of plasma membrane Ca2+-permeable channels and Ca2+-ATPases. Viewed paradermally, and proximal to the cytosol-plasma membrane interface, the Ca2+ signal was organized into discrete patches that aligned spatially with clusters of Ca2+-permeable channels. Mathematical modelling demonstrated that these patches of cytosolic Ca2+ were consistent with inward-directed plumes of elevated [Ca2+]cyt. Plume formation depended upon an alternating distribution of Ca2+-permeable channels and Ca2+-ATPase clusters. On further inward diffusion, the Ca2+ plumes coalesced into a uniform Ca2+ signal. Blocking or dispersing the Ca2+ plumes inhibited deposition of wall ingrowth papillae, while uniform wall formation remained unaltered. A working model envisages that cytosolic Ca2+ plumes define the loci at which wall ingrowth papillae are deposited.

DOI 10.1093/jxb/eru460
Citations Scopus - 2Web of Science - 3
Co-authors John Patrick, Derek Laver, David Mccurdy
2015 Beard DJ, McLeod DD, Logan CL, Murtha LA, Imtiaz MS, van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke.', J Cereb Blood Flow Metab, 35 861-872 (2015)
DOI 10.1038/jcbfm.2015.2
Co-authors Lucy Murtha, Damian Mcleod, Neil Spratt
2015 Hashitani H, Mitsui R, Masaki S, Van Helden DF, 'Pacemaker role of pericytes in generating synchronized spontaneous Ca(2+) transients in the myenteric microvasculature of the guinea-pig gastric antrum.', Cell Calcium, (2015)
DOI 10.1016/j.ceca.2015.06.012
2015 Zhang HM, van Helden DF, McCurdy DW, Offler CE, Patrick JW, 'Plasma Membrane Ca2+-Permeable Channels are Differentially Regulated by Ethylene and Hydrogen Peroxide to Generate Persistent Plumes of Elevated Cytosolic Ca2+ During Transfer Cell Trans-Differentiation.', Plant Cell Physiol, (2015)
DOI 10.1093/pcp/pcv100
Co-authors David Mccurdy, John Patrick
2015 Beard DJ, Mcleod DD, Logan CL, Murtha LA, Imtiaz MS, Van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 35 861-872 (2015)

Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite stable arter... [more]

Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite stable arterial occlusion. The cause for 'collateral failure' is unknown. We recently showed that intracranial pressure (ICP) rises dramatically but transiently 24 hours after even minor experimental stroke. We hypothesized that ICP elevation would reduce collateral blood flow. First, we investigated the regulation of flow through collateral vessels and the penetrating arterioles arising from them during stroke reperfusion. Wistar rats were subjected to intraluminal middle cerebral artery (MCA) occlusion (MCAo). Individual pial collateral and associated penetrating arteriole blood flow was quantified using fluorescent microspheres. Baseline bidirectional flow changed to MCA-directed flow and increased by >450% immediately after MCAo. Collateral diameter changed minimally. Second, we determined the effect of ICP elevation on collateral and watershed penetrating arteriole flow. Intracranial pressure was artificially raised in stepwise increments during MCAo. The ICP increase was strongly correlated with collateral and penetrating arteriole flow reductions. Changes in collateral flow post-stroke appear to be primarily driven by the pressure drop across the collateral vessel, not vessel diameter. The ICP elevation reduces cerebral perfusion pressure and collateral flow, and is the possible explanation for 'collateral failure' in stroke-in-progression.

DOI 10.1038/jcbfm.2015.2
Co-authors Lucy Murtha, Damian Mcleod, Neil Spratt
2015 Nikolaev YA, Dosen PJ, Laver DR, Van Helden DF, Hamill OP, 'Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons', Brain Research, 1608 1-13 (2015)

The mammalian brain is a mechanosensitive organ that responds to different mechanical forces ranging from intrinsic forces implicated in brain morphogenesis to extrinsic forces th... [more]

The mammalian brain is a mechanosensitive organ that responds to different mechanical forces ranging from intrinsic forces implicated in brain morphogenesis to extrinsic forces that can cause concussion and traumatic brain injury. However, little is known of the mechanosensors that transduce these forces. In this study we use cell-attached patch recording to measure single mechanically-gated (MG) channel currents and their affects on spike activity in identified neurons in neonatal mouse brain slices. We demonstrate that both neocortical and hippocampal pyramidal neurons express stretch-activated MG cation channels that are activated by suctions of ~25 mm Hg, have a single channel conductance for inward current of 50-70 pS and show weak selectivity for alkali metal cations (i.e., Na+++). Significantly, single MG channel currents activated on the soma trigger spiking/action potentials in both neocortical and hippocampal pyramidal neurons. Not all neuron types studied here expressed MG channel currents. In particular, locus coeruleus and cerebellar Purkinje neurons showed no detectable MG channel activity. Moreover their robust rhythmic spike activity was resistant to mechanical modulation. Our observation that a single MG channel current can trigger spiking predicates the need for reassessment of the long held view that the impulse output of central neurons depends only upon their intrinsic voltage-gated channels and/or their integrated synaptic input.

DOI 10.1016/j.brainres.2015.02.051
Co-authors Derek Laver
2015 Beard DJ, Mcleod DD, Logan CL, Murtha LA, Imtiaz MS, Van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 35 861-872 (2015)

Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite stable arter... [more]

Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite stable arterial occlusion. The cause for 'collateral failure' is unknown. We recently showed that intracranial pressure (ICP) rises dramatically but transiently 24 hours after even minor experimental stroke. We hypothesized that ICP elevation would reduce collateral blood flow. First, we investigated the regulation of flow through collateral vessels and the penetrating arterioles arising from them during stroke reperfusion. Wistar rats were subjected to intraluminal middle cerebral artery (MCA) occlusion (MCAo). Individual pial collateral and associated penetrating arteriole blood flow was quantified using fluorescent microspheres. Baseline bidirectional flow changed to MCA-directed flow and increased by >450% immediately after MCAo. Collateral diameter changed minimally. Second, we determined the effect of ICP elevation on collateral and watershed penetrating arteriole flow. Intracranial pressure was artificially raised in stepwise increments during MCAo. The ICP increase was strongly correlated with collateral and penetrating arteriole flow reductions. Changes in collateral flow post-stroke appear to be primarily driven by the pressure drop across the collateral vessel, not vessel diameter. The ICP elevation reduces cerebral perfusion pressure and collateral flow, and is the possible explanation for 'collateral failure' in stroke-in-progression.

DOI 10.1038/jcbfm.2015.2
Co-authors Damian Mcleod, Lucy Murtha, Neil Spratt
2015 Nikolaev YA, Dosen PJ, Laver DR, van Helden DF, Hamill OP, 'Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons.', Brain Res, 1608 1-13 (2015)
DOI 10.1016/j.brainres.2015.02.051
Co-authors Derek Laver
2015 Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR, 'Essential Role of Calmodulin in RyR Inhibition by Dantrolene.', Mol Pharmacol, 88 57-63 (2015)
DOI 10.1124/mol.115.097691
Co-authors Derek Laver
2014 Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, et al., 'Differences in the regulation of RyR2 from human, sheep, and rat by Ca²¿ and Mg²¿ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.', J Gen Physiol, 144 263-271 (2014) [C1]
DOI 10.1085/jgp.201311157
Citations Scopus - 2Web of Science - 1
Co-authors Derek Laver, Tony Quail
2014 van Helden DF, Thomas PA, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK, 'Pharmacological approaches that slow lymphatic flow as a snakebite first aid.', PLoS Negl Trop Dis, 8 e2722 (2014) [C1]
DOI 10.1371/journal.pntd.0002722
Citations Web of Science - 1
Co-authors Geoff Isbister, Derek Laver
2014 Gravina FS, Van Helden DF, Kerr KP, De Oliveira RB, Jobling P, 'Phasic contractions of the mouse vagina and cervix at different phases of the estrus cycle and during late pregnancy', PLoS ONE, 9 (2014) [C1]

Conclusions/Significance: Cervical smooth muscle strips taken from mice in estrus, metestrus or late pregnancy were generally spontaneously active. Vaginal smooth muscle strips we... [more]

Conclusions/Significance: Cervical smooth muscle strips taken from mice in estrus, metestrus or late pregnancy were generally spontaneously active. Vaginal smooth muscle strips were normally quiescent but could be induced to exhibit phasic contractions independent on phase of the estrus cycle or late pregnancy. Spontaneous cervical or TEA-induced vaginal phasic contractions were not mediated by ICs or intracellular Ca2+ stores. Given that vaginal smooth muscle is normally quiescent then it is likely that increases in hormones such as oxytocin, as might occur through sexual stimulation, enhance the effectiveness of such pacemaking until phasic contractile activity emerges.

DOI 10.1371/journal.pone.0111307
Citations Scopus - 2Web of Science - 3
Co-authors Karen Kerr, Phillip Jobling
2014 van Helden DF, 'The lymphangion: A not so 'primitive' heart', Journal of Physiology, 592 5353-5354 (2014) [C3]
DOI 10.1113/jphysiol.2014.286039
2014 Mehra D, Imtiaz MS, Van Helden DF, Knollmann BC, Laver DR, 'Multiple modes of ryanodine receptor 2 inhibition by flecainide', Molecular Pharmacology, 86 696-706 (2014) [C1]

Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flec... [more]

Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na+ and RyR2 channels and prevents CPVT. The purpose of this study is to identify inhibitory mechanisms of flecainide on RyR2. RyR2 were isolated from sheep heart, incorporated into lipid bilayers, and investigated by singlechannel recording under various activating conditions, including the presence of cytoplasmic ATP (2mM) and a range of cytoplasmic [Ca2+], [Mg2+], pH, and [caffeine]. Flecainide applied to either the cytoplasmic or luminal sides of the membrane inhibited RyR2 by two distinct modes: 1) a fast block consisting of brief substate and closed events with a mean duration of ~1 ms, and 2) a slow block consisting of closed events with a mean duration of ~1 second. Both inhibition modes were alleviated by increasing cytoplasmic pH from 7.4 to 9.5 but were unaffected by luminal pH. The slow block was potentiated in RyR2 channels that had relatively low open probability, whereas the fast block was unaffected by RyR2 activation. These results show that these two modes are independent mechanisms for RyR2 inhibition, both having a cytoplasmic site of action. The slow mode is a closed-channel block, whereas the fast mode blocks RyR2 in the open state. At diastolic cytoplasmic [Ca2+] (100 nM), flecainide possesses an additional inhibitory mechanism that reduces RyR2 burst duration. Hence, multiple modes of action underlie RyR2 inhibition by flecainide.

DOI 10.1124/mol.114.094623
Citations Scopus - 2Web of Science - 3
Co-authors Derek Laver
2013 Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR, 'ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.', PLoS One, 8 e58334 (2013) [C1]
DOI 10.1371/journal.pone.0058334
Co-authors Rick Thorne, Derek Laver
2012 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1]
Citations Scopus - 1Web of Science - 1
Co-authors Robert Callister, Alan Brichta, Rebecca Lim
2011 De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1]
Citations Scopus - 3Web of Science - 3
Co-authors Alan Brichta, Robert Callister, Rebecca Lim
2011 Laver DR, Van Helden DF, 'Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels', Journal of Molecular and Cellular Cardiology, 51 357-369 (2011) [C1]
DOI 10.1016/j.yjmcc.2011.05.009
Citations Scopus - 7Web of Science - 8
Co-authors Derek Laver
2011 Saul ME, Thomas PA, Dosen PJ, Isbister GK, O'Leary MA, Whyte IM, et al., 'A pharmacological approach to first aid treatment for snakebite', Nature Medicine, 17 809-811 (2011) [C1]
DOI 10.1038/nm.2382
Citations Scopus - 15Web of Science - 17
Co-authors Geoff Isbister, Sally Mcfadden
2011 Gravina FS, Jobling P, Kerr KP, De Oliveira R, Parkington HC, Van Helden DF, 'Oxytocin depolarizes mitochondria in isolated myometrial cells', Experimental Physiology, 96 949-956 (2011) [C1]
DOI 10.1113/expphysiol.2011.058388
Citations Scopus - 1Web of Science - 1
Co-authors Karen Kerr, Phillip Jobling
2010 Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Calculated two-photon fluorescence correction factors for reflective scan engines', Applied Optics, 49 1472-1479 (2010) [C1]
DOI 10.1364/AO.49.001472
Citations Scopus - 1Web of Science - 1
Co-authors John Holdsworth, Galiya Sharafutdinova
2010 Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Improved field scanner incorporating parabolic optics. Part 2: experimental verification and potential for volume scanning', Applied Optics, 49 5517-5527 (2010) [C1]
DOI 10.1364/AO.49.005517
Citations Scopus - 2Web of Science - 2
Co-authors John Holdsworth, Galiya Sharafutdinova
2010 Imtiaz MS, Von Der Weid P-Y, Van Helden DF, 'Synchronization of Ca2+oscillations: A coupled oscillator-based mechanism in smooth muscle', FEBS Journal, 277 278-285 (2010) [C1]
DOI 10.1111/j.1742-4658.2009.07437.x
Citations Scopus - 13Web of Science - 11
2010 Gravina FS, Parkington HC, Kerr KP, De Oliveira R, Jobling P, Coleman HA, et al., 'Role of mitochondria in contraction and pacemaking in the mouse uterus', British Journal of Pharmacology, 161 1375-1390 (2010) [C1]
DOI 10.1111/j.1476-5381.2010.00949.x
Citations Scopus - 7Web of Science - 7
Co-authors Karen Kerr, Phillip Jobling
2010 Imtiaz MS, Von Der Weid P-Y, Laver DR, Van Helden DF, 'SR Ca2+ store refill-a key factor in cardiac pacemaking', Journal of Molecular and Cellular Cardiology, 49 412-426 (2010) [C1]
DOI 10.1016/j.yjmcc.2010.03.015
Citations Scopus - 9Web of Science - 7
Co-authors Derek Laver
2010 De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
DOI 10.1016/j.jneumeth.2010.03.029
Citations Scopus - 6Web of Science - 6
Co-authors Alan Brichta, Brett Graham, Robert Callister, Rebecca Lim
2010 Van Helden DF, Laver DR, Holdsworth JL, Imtiaz MS, 'Generation and propagation of gastric slow waves', Clinical and Experimental Pharmacology and Physiology, 37 516-524 (2010) [C1]
DOI 10.1111/j.1440-1681.2009.05331.x
Citations Scopus - 21Web of Science - 17
Co-authors John Holdsworth, Derek Laver
2010 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Pacemaker currents in mouse locus coeruleus neurons', Neuroscience, 170 166-177 (2010) [C1]
DOI 10.1016/j.neuroscience.2010.06.028
Citations Scopus - 9Web of Science - 8
Co-authors Alan Brichta, Robert Callister
2009 Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Improved field scanner incorporating parabolic optics: Part 1: Simulation', Applied Optics, 48 4389-4396 (2009) [C1]
DOI 10.1364/AO.48.004389
Citations Scopus - 5Web of Science - 5
Co-authors Galiya Sharafutdinova, John Holdsworth
2009 Imtiaz MS, von der Weid P-Y, Crowe M, van Helden D, 'Lymphatic pacemaking', FASEB JOURNAL, 23 (2009) [E3]
2008 Odell AF, Van Helden DF, Scott JL, 'The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels', Journal of Biological Chemistry, 283 4395-4407 (2008) [C1]
DOI 10.1074/jbc.m709729200
Citations Scopus - 26Web of Science - 25
2008 Von Der Weid P-Y, Rahman M, Imtiaz MS, Van Helden DF, 'Spontaneous transient depolarizations in lymphatic vessels of the guinea pig mesentery: Pharmacology and implication for spontaneous contractility', American Journal of Physiology: Heart and Circulatory Physiology, 295 H1989-H2000 (2008) [C1]
DOI 10.1152/ajpheart.00007.2008
Citations Scopus - 22Web of Science - 18
2007 Smith R, Van Helden DF, Hirst JJ, Zakar T, Read MA, Chan EC, et al., 'Pathological interactions with the timing of birth and uterine activation', Australian & New Zealand Journal of Obstetrics & Gynaecology, 47 430-437 (2007) [C1]
DOI 10.1111/j.1479-828x.2007.00775.x
Citations Scopus - 8Web of Science - 8
Co-authors Hannah Palliser, Roger Smith, Jon Hirst
2007 Imtiaz MS, Zhao J, Hosaka K, Von Der Weid PY, Crowe M, Van Helden DF, 'Pacemaking through Ca2+ stores interacting as coupled oscillators via membrane depolarization', Biophysical Journal, 92 3843-3861 (2007) [C1]
DOI 10.1529/biophysj.106.095687
Citations Scopus - 22Web of Science - 20
2006 Dielenberg R, Halasz P, Hosaka K, Van Helden DF, 'Vessel motion measurement in real-time using movement detection at multiple regions of interest', Journal of Neuroscience Methods, 152 40-47 (2006) [C1]
DOI 10.1016/j.jneumeth.2005.08.005
Citations Scopus - 7Web of Science - 6
2006 Hosaka K, Rayner SE, Von Der Weid PY, Zhao J, Imtiaz MS, Van Helden DF, 'Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs', American Journal of Physiology-Heart and Circulatory Physiology, 290 H813-H822 (2006) [C1]
DOI 10.1152/ajpheart.00543.2005
Citations Web of Science - 18
2006 Van Helden DF, Hosaka K, Imtiaz MS, 'Rhythmicity in the microcirculation', Clinical Hemorheology and Microcirculation, 34 59-66 (2006) [C1]
Citations Scopus - 8Web of Science - 6
2006 Imtiaz MS, Katnik CP, Smith DW, Van Helden DF, 'Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations', Biophysical Journal, 90 1-23 (2006) [C1]
DOI 10.1529/biophysj.104.058743
Citations Scopus - 27Web of Science - 28
2005 Odell AF, Scott JL, Van Helden DF, 'Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4', Journal of Biological Chemistry, 280 37974-37987 (2005) [C1]
DOI 10.1074/jbc.M503646200
Citations Scopus - 67Web of Science - 65
2004 Ferrusi I, Zhao J, Van Helden DF, Von Der Weid P-Y, 'Cyclopiazonic acid decreases spontaneous transient depolarizations in guinea pig mesenteric lymphatic vessels in endothelium-dependent and -independent manners', Am J Physiol Heart Circ Physiol, 286 H2287-H2295 (2004) [C1]
DOI 10.1152/ajpheart.00739.2003
Citations Scopus - 11Web of Science - 11
2003 Zhao J, Van Helden DF, 'ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery', British Journal of Pharmacology, 140 1399-1413 (2003) [C1]
DOI 10.1038/sj.bjp.0705573
Citations Scopus - 17Web of Science - 16
2003 Van Helden DF, Imtiaz MS, 'Ca2+ phase waves: a basis for cellular pacemaking and long-range synchronicity in the guinea-pig gastric pylorus', The Journal of Physiology, 548.1 271-296 (2003) [C1]
DOI 10.1113/jphysiol.2002.033720
Citations Scopus - 66Web of Science - 62
2002 Imtiaz MS, Smith DW, Van Helden DF, 'A Theoretical Model Of Slow Wave Regulation Using Voltage-Dependent Synthesis Of Inositol 1,4,5-Trisphosphate', Biophyhsical Journal, Vol. 83 1877-1890 (2002) [C1]
Citations Scopus - 28Web of Science - 28
2002 Zhao J, Van Helden DF, 'ATP-induced endothelium-independent enhancement of lymphatic vasomotion in guinea-pig mesentery involves P2x and P2y receptors', British Journal of Pharmacology, 137 477-487 (2002) [C1]
Citations Scopus - 16Web of Science - 12
2001 Von Der Weid P-Y, Zhao J, Van Helden DF, 'Nitric oxide decreases pacemaker activity in lymphatic vessels of guinea pig mesentery', Am J Physiol Heart Circ Physiol, 280 H2707-H2716 (2001) [C1]
Citations Scopus - 55Web of Science - 49
2000 Van Helden DF, Imtiaz MS, Nurgaliyeva K, Von Der Weid P-Y, Dosen PJ, 'Role of calcium stores and membrane voltage in the generation of slow wave action potentials in guinea-pig gastric pylorus', Journal of Physiology, 524.1 245-265 (2000) [C1]
Citations Scopus - 105Web of Science - 101
2000 Van Helden D, Zhao J, 'Lymphatic Vasomotion', Clinical and Experimental Pharmacology and Physiology, 27 1014-1018 (2000) [C1]
Citations Scopus - 20Web of Science - 16
1999 Gao JN, Zhao J, Rayner SE, Van Helden DF, 'Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A(2)', BRITISH JOURNAL OF PHARMACOLOGY, 127 1597-1602 (1999)
DOI 10.1038/sj.bjp.0702710
Citations Scopus - 29Web of Science - 27
1997 Rayner SE, VanHelden DF, 'Evidence that the substance P-induced enhancement of pacemaking in lymphatics of the guinea-pig mesentery occurs through endothelial release of thromboxane A(2)', BRITISH JOURNAL OF PHARMACOLOGY, 121 1589-1596 (1997)
DOI 10.1038/sj.bjp.0701306
Citations Scopus - 31Web of Science - 25
1997 Crowe MJ, vonderWeid PY, Brock JA, VanHelden DF, 'Co-ordination of contractile activity in guinea-pig mesenteric lymphatics', JOURNAL OF PHYSIOLOGY-LONDON, 500 235-244 (1997)
Citations Scopus - 33Web of Science - 28
1997 vonderWeid PY, VanHelden DF, 'Functional electrical properties of the endothelium in lymphatic vessels of the guinea-pig mesentery', JOURNAL OF PHYSIOLOGY-LONDON, 504 439-451 (1997)
Citations Scopus - 11Web of Science - 12
1996 Oba T, Koshita M, Van Helden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers.', The American journal of physiology, 271 C819-C824 (1996)
1996 Von der Weid PY, Van Helden DF, 'Beta-adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery.', The American journal of physiology, 270 H1687-H1695 (1996)
1996 Brent PJ, Pang G, Little G, Dosen PJ, VanHelden DF, 'The sigma receptor ligand, reduced haloperidol, induces apoptosis and increases intracellular-free calcium levels [Ca2+](i) in colon and mammary adenocarcinoma cells', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 219 219-226 (1996)
DOI 10.1006/bbrc.1996.0208
Citations Scopus - 44Web of Science - 39
1996 Zipfel WR, OMalley JP, VanHelden D, Williams RM, Guild JB, Salpeter MM, Webb WW, 'Characterization of spontaneous calcium waves and sparks in primary cultures of fetal rat myotubes using two photon excitation point and line scanning microscopy.', BIOPHYSICAL JOURNAL, 70 WP283-WP283 (1996)
Citations Web of Science - 2
1996 Hashitani H, VanHelden DF, Suzuki H, 'Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra', BRITISH JOURNAL OF PHARMACOLOGY, 118 1627-1632 (1996)
Citations Scopus - 93Web of Science - 92
1996 vonderWeid PY, Crowe MJ, VanHelden DF, 'Endothelium-dependent modulation of pacemaking in lymphatic vessels of the guinea-pig mesentery', JOURNAL OF PHYSIOLOGY-LONDON, 493 563-575 (1996)
Citations Scopus - 68Web of Science - 61
1996 Stiles JR, VanHelden D, Bartol TM, Salpeter EE, Salpeter MM, 'Miniature endplate current rise times <100 mu s from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93 5747-5752 (1996)
DOI 10.1073/pnas.93.12.5747
Citations Scopus - 118Web of Science - 114
1996 Brock JA, VanHelden DF, Dosen P, Rush RA, 'Prevention of high blood pressure by reducing sympathetic innervation in the spontaneously hypertensive rat', JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 61 97-102 (1996)
DOI 10.1016/S0165-1838(96)00063-X
Citations Scopus - 27Web of Science - 27
1996 vonderWeid PY, VanHelden DF, 'beta-Adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 270 H1687-H1695 (1996)
Citations Web of Science - 22
1996 Von Der Weid P-Y, Van Helden DF, 'ß-Adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery', American Journal of Physiology - Heart and Circulatory Physiology, 270 (1996)

Intracellular microelectrode recordings were performed to investigate the consequences of ß-adrenoceptor activation in smooth muscle of guinea pig mesenteric lymphatic vessels. I... [more]

Intracellular microelectrode recordings were performed to investigate the consequences of ß-adrenoceptor activation in smooth muscle of guinea pig mesenteric lymphatic vessels. Isoproterenol (Iso) hyperpolarized the membrane with an associated increase in membrane conductance and decreased the amplitude of spontaneous transient depolarizations. Iso effects were mimicked by forskolin (FSK), 3-isobutyl-1-methylxanthine, and two adenosine 3',5'- cyclic monophosphate (cAMP) derivatives. Iso- and FSK-induced hyperpolarizations were inhibited by H89, an inhibitor of cAMP-dependent protein kinase A, increased in K+-free solution, but were not affected by ouabain or by the nitric oxide synthase inhibitor N(¿)-nitro-L-arginine. They were partially inhibited by 20 mM tetraethylammonium (~40%) or by 2.5 mM 4-aminopyridine (~55%). The Iso-induced hyperpolarization was partially inhibited by iberiotoxin (20 nM) and charybdotoxin (40 nM), whereas the FSK- induced hyperpolarization was less affected. In cells where the Iso-induced hyperpolarization was decreased by 40 µM 1,2-bis(2-aminophenoxy)ethane- N,N,N',N'-tetraacetic acid, acetoxymethyl ester form, the FSK-induced hyperpolarization was little changed. Our results indicate that in guinea pig mesenteric lymphatic vessels, ß-adrenoceptor stimulation activates a protein kinase A-dependent K+ conductance, involving more than one channel type.

Citations Scopus - 26
1996 Oba T, Koshita M, VanHelden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 271 C819-C824 (1996)
Citations Web of Science - 26
1996 Oba T, Koshita M, Van Helden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers', American Journal of Physiology - Cell Physiology, 271 (1996)

Effects of niflumic acid and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) on frog skeletal muscle ryanodine receptors have been studied by incorporating sarcoplasmic re... [more]

Effects of niflumic acid and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) on frog skeletal muscle ryanodine receptors have been studied by incorporating sarcoplasmic reticulum vesicles into planar lipid bilayers. Niflumic acid increased the mean open probability (P(o)) at 10 µM and decreased P(o) at 100 µM with no change in open time constants, unitary conductance, and reversal potential. The P(o) was augmented by DIDS at 5-200 µM without affecting either unitary conductance or reversal potential. DIDS induced a new third open time constant, probably contributing to a long- lived open state. Channels modified by niflumic acid or DIDS still responded to Ca2+ release channel modulators. These results provide evidence that niflumic acid and DIDS modify the gating mechanism of ryanodine receptors without affecting binding sites to the modulators and the physical pathway of the conducting pore. p-Chloromercuriphenyl sulfonic acid (pCMPS) transiently increased the P(o). The channel modified by DIDS responded to pCMPS, whereas that by ryanodine did not. The long open state of the channel induced by DIDS is produced by a quite different mechanism(s) from that by ryanodine. Contrary to cardiac ryanodine receptors, P(o) of skeletal muscle channels was independent of voltage after DIDS modification.

Citations Scopus - 26
1995 BRENT PJ, DOSEN PJ, PANG G, VANHELDEN DF, 'THE SIGMA-BINDING SITE LIGAND, REDUCED HALOPERIDOL (RHAL), INCREASES INTRACELLULAR FREE CALCIUM LEVELS [CA2+]I IN COLON-CANCER CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S13-S13 (1995)
1995 BROCK JA, VANHELDEN DF, 'ENHANCED EXCITATORY JUNCTION POTENTIALS IN MESENTERIC-ARTERIES FROM SPONTANEOUSLY HYPERTENSIVE RATS', PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 430 901-908 (1995)
DOI 10.1007/BF01837403
Citations Scopus - 47Web of Science - 44
1994 BATES RC, BURET A, VANHELDEN DF, HORTON MA, BURNS GF, 'APOPTOSIS INDUCED BY INHIBITION OF INTERCELLULAR CONTACT', JOURNAL OF CELL BIOLOGY, 125 403-415 (1994)
DOI 10.1083/jcb.125.2.403
Citations Scopus - 234Web of Science - 253
1993 KLEMM MF, VANHELDEN DF, LUFF SE, 'ULTRASTRUCTURAL ANALYSIS OF SYMPATHETIC NEUROMUSCULAR-JUNCTIONS ON MESENTERIC VEINS OF THE GUINEA-PIG', JOURNAL OF COMPARATIVE NEUROLOGY, 334 159-167 (1993)
DOI 10.1002/cne.903340113
Citations Scopus - 15Web of Science - 17
1993 VANHELDEN DF, 'PACEMAKER POTENTIALS IN LYMPHATIC SMOOTH-MUSCLE OF THE GUINEA-PIG MESENTERY', JOURNAL OF PHYSIOLOGY-LONDON, 471 465-479 (1993)
Citations Scopus - 107Web of Science - 107
1993 BERESFORDSMITH B, NESBITT KV, VANHELDEN DF, 'EDGE-DETECTION AT MULTIPLE LOCATIONS USING A RADAR TRACKING ALGORITHM AS EXEMPLIFIED IN ISOLATED GUINEA-PIG LYMPHATIC VESSELS', JOURNAL OF NEUROSCIENCE METHODS, 49 69-79 (1993)
DOI 10.1016/0165-0270(93)90110-D
Citations Scopus - 9Web of Science - 9
Co-authors Keith Nesbitt
1991 VANHELDEN DF, 'SPONTANEOUS AND NORADRENALINE-INDUCED TRANSIENT DEPOLARIZATIONS IN THE SMOOTH-MUSCLE OF GUINEA-PIG MESENTERIC VEIN', JOURNAL OF PHYSIOLOGY-LONDON, 437 511-541 (1991)
Citations Scopus - 40Web of Science - 48
1990 VANHELDEN DF, WOOLRIDGE S, 'ROLE OF NERVES IN HYPERTENSION', NATURE, 348 118-119 (1990)
DOI 10.1038/348118b0
Citations Scopus - 6Web of Science - 7
1989 VANHELDEN DF, 'NORADRENALINE-INDUCED TRANSIENT DEPOLARIZATIONS IN THE SMOOTH-MUSCLE OF ISOLATED GUINEA-PIG MESENTERIC LYMPHATICS', JOURNAL OF PHYSIOLOGY-LONDON, 418 P173-P173 (1989)
Citations Web of Science - 6
1988 VANHELDEN DF, 'ELECTROPHYSIOLOGY OF NEUROMUSCULAR-TRANSMISSION IN GUINEA-PIG MESENTERIC VEINS', JOURNAL OF PHYSIOLOGY-LONDON, 401 469-488 (1988)
Citations Scopus - 20Web of Science - 32
1988 VANHELDEN DF, 'AN ALPHA-ADRENOCEPTOR-MEDIATED CHLORIDE CONDUCTANCE IN MESENTERIC VEINS OF THE GUINEA-PIG', JOURNAL OF PHYSIOLOGY-LONDON, 401 489-501 (1988)
Citations Web of Science - 46
1988 Van Helden DF, 'An a-adrenoceptor-mediated chloride conductance in mesenteric veins of the guinea-pig', Journal of Physiology, 401 489-501 (1988)

1. The ionic basis of the depolarizing responses resulting from ionophoresis of noradrenaline onto the smooth muscle of mesenteric veins has been investigated using electrically s... [more]

1. The ionic basis of the depolarizing responses resulting from ionophoresis of noradrenaline onto the smooth muscle of mesenteric veins has been investigated using electrically short segments of vessel. 2. Isolated cut segments of vein were effectively isopotential as assessed by the voltage response to a step change in current. The mean input resistance and time constant of the smooth muscle were 24 MO and 131 ms respectively. 3. Data on the noradrenaline-induced slow depolarization indicated that it resulted from a decrease in conductance to potassium ions consistent with the finding of Suzuki (1981). 4. The fast noradrenaline-induced depolarization was found to have a reversal potential of about -22 mV. 5. Exposure to low-chloride solution caused greater than 90% suppression of this fast response with a 50% reduction occurring in less than 2 min. This suppression was not due to a negative shift in reversal potential. 6. The fast response underwent a large positive shift in reversal potential directly after changeover to low-chloride solution at times when any inactivation of the response was minimal. By contrast the fast response showed no evidence implicating either sodium or calcium as charge-carrying ions. 7. It is concluded that fast depolarization is carried by chloride ions.

Citations Scopus - 28
1986 HIRST GDS, SILVERBERG GD, VANHELDEN DF, 'THE ACTION-POTENTIAL AND UNDERLYING IONIC CURRENTS IN PROXIMAL RAT MIDDLE CEREBRAL ARTERIOLES', JOURNAL OF PHYSIOLOGY-LONDON, 371 289-304 (1986)
Citations Scopus - 37Web of Science - 84
1986 HILL CE, HIRST GDS, SILVERBERG GD, VANHELDEN DF, 'SYMPATHETIC INNERVATION AND EXCITABILITY OF ARTERIOLES ORIGINATING FROM THE RAT MIDDLE CEREBRAL-ARTERY', JOURNAL OF PHYSIOLOGY-LONDON, 371 305-& (1986)
Citations Scopus - 24Web of Science - 30
1985 Hill CE, Hendry IA, Ngu MC, van Helden DF, 'Subpopulations of sympathetic neurones differ in their sensitivity to nerve growth factor antiserum.', Brain Research, 355 121-130 (1985)

Sympathetic postganglionic nerve fibres supplying mesenteric arteries and intrinsic ileal neurones differ in their characteristics of regeneration. Since the latter population of ... [more]

Sympathetic postganglionic nerve fibres supplying mesenteric arteries and intrinsic ileal neurones differ in their characteristics of regeneration. Since the latter population of neurones occurs predominantly in prevertebral ganglia, which have been reported to be spared to some extent after treatment with antiserum to nerve growth factor (anti-NGF), we have investigated whether the two populations were differentially sensitive to anti-NGF. Newborn rats were treated daily for the first postnatal week with either anti-NGF or 154 mM NaCl solution. At 4 and 8 weeks of age, the presence of a functional sympathetic innervation to the mesenteric arteries and the gut was determined and correlated with the fluorescence histochemical demonstration of noradrenergic fibres. At both ages, stimulation of extrinsic sympathetic fibres caused an inhibition of gut motility, while the mesenteric arteries completely lacked a sympathetic innervation. Retrograde labelling of nerve cell bodies in control and antiserum treated rats confirmed that the sympathetic neurones supplying the ileal neurones were located in the prevertebral, superior mesenteric and coeliac ganglia and in the splanchnic ganglia lying along the greater splanchnic nerves. By interference from retrograde labelling in control animals, sympathetic neurones supplying the mesenteric arteries were present in all these ganglia, as well as in the thoracic and lumbar paravertebral sympathetic chains. The results suggest that two functionally distinct populations of sympathetic neurones, which overlap considerably in their distributions, are differentially sensitive to the immunological postnatal removal of NGF.

Citations Scopus - 17
1985 HIRST GDS, DEGLERIA S, VANHELDEN DF, 'NEUROMUSCULAR-TRANSMISSION IN ARTERIOLES', EXPERIENTIA, 41 874-879 (1985)
DOI 10.1007/BF01970004
Citations Scopus - 10Web of Science - 23
1985 TAYLOR WM, VANDEPOL E, VANHELDEN DF, REINHART PH, BYGRAVE FL, 'EFFECT OF DEPOLARIZING CONCENTRATIONS OF POTASSIUM ON CALCIUM-UPTAKE AND METABOLISM IN RAT-LIVER', FEBS LETTERS, 183 70-74 (1985)
DOI 10.1016/0014-5793(85)80956-X
Citations Scopus - 18Web of Science - 25
1985 HIRST GDS, JOHNSON SM, VANHELDEN DF, 'THE CALCIUM CURRENT IN A MYENTERIC NEURON OF THE GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 361 297-314 (1985)
Citations Scopus - 45Web of Science - 64
1985 HIRST GDS, JOHNSON SM, VANHELDEN DF, 'THE SLOW CALCIUM-DEPENDENT POTASSIUM CURRENT IN A MYENTERIC NEURON OF THE GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 361 315-337 (1985)
Citations Scopus - 99Web of Science - 128
1985 HILL CE, HIRST GDS, NGU MC, VANHELDEN DF, 'SYMPATHETIC POSTGANGLIONIC REINNERVATION OF MESENTERIC-ARTERIES AND ENTERIC NEURONS OF THE ILEUM OF THE RAT', JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 14 317-334 (1985)
DOI 10.1016/0165-1838(85)90079-7
Citations Scopus - 32Web of Science - 40
1985 HILL CE, HENDRY IA, NGU MC, VANHELDEN DF, 'SUBPOPULATIONS OF SYMPATHETIC NEURONS DIFFER IN THEIR SENSITIVITY TO NERVE GROWTH-FACTOR ANTISERUM', DEVELOPMENTAL BRAIN RESEARCH, 23 121-130 (1985)
DOI 10.1016/0165-3806(85)90011-2
Citations Scopus - 18Web of Science - 24
1984 FINKEL AS, HIRST GDS, VANHELDEN DF, 'SOME PROPERTIES OF EXCITATORY JUNCTION CURRENTS RECORDED FROM SUBMUCOSAL ARTERIOLES OF GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 351 87-98 (1984)
Citations Scopus - 18Web of Science - 48
1983 HILL CE, HIRST GDS, VANHELDEN DF, 'DEVELOPMENT OF SYMPATHETIC INNERVATION TO PROXIMAL AND DISTAL ARTERIES OF THE RAT MESENTERY', JOURNAL OF PHYSIOLOGY-LONDON, 338 129-147 (1983)
Citations Scopus - 35Web of Science - 53
1983 ARHEM P, VANHELDEN D, 'EFFECTS OF ALIPHATIC-ALCOHOLS ON MYELINATED NERVE MEMBRANE', ACTA PHYSIOLOGICA SCANDINAVICA, 119 105-107 (1983)
DOI 10.1111/j.1748-1716.1983.tb07312.x
Citations Scopus - 5Web of Science - 8
1982 HIRST GDS, VANHELDEN DF, 'IONIC BASIS OF THE RESTING POTENTIAL OF SUBMUCOSAL ARTERIOLES IN THE ILEUM OF THE GUINEA-PIG', JOURNAL OF PHYSIOLOGY-LONDON, 333 53-67 (1982)
Citations Scopus - 34Web of Science - 63
1982 GREEFF NG, KEYNES RD, VANHELDEN DF, 'FRACTIONATION OF THE ASYMMETRY CURRENT IN THE SQUID GIANT-AXON INTO INACTIVATING AND NON-INACTIVATING COMPONENTS', PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 215 375-389 (1982)
DOI 10.1098/rspb.1982.0048
Citations Scopus - 15Web of Science - 42
1982 KEYNES RD, GREEFF NG, VANHELDEN DF, 'THE RELATIONSHIP BETWEEN THE INACTIVATING FRACTION OF THE ASYMMETRY CURRENT AND GATING OF THE SODIUM-CHANNEL IN THE SQUID GIANT-AXON', PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 215 391-404 (1982)
DOI 10.1098/rspb.1982.0049
Citations Scopus - 12Web of Science - 27
1981 HARVEY AL, VANHELDEN DF, 'AGE-RELATED-CHANGES IN PROPERTIES OF ACETYLCHOLINE-RECEPTORS IN SINGLY AND MULTIPLY INNERVATED SKELETAL-MUSCLES OF THE CHICKEN', BRITISH JOURNAL OF PHARMACOLOGY, 74 P297-P298 (1981)
1981 HARVEY AL, VANHELDEN D, 'ACETYLCHOLINE-RECEPTORS IN SINGLY AND MULTIPLY INNERVATED SKELETAL-MUSCLE FIBERS OF THE CHICKEN DURING DEVELOPMENT', JOURNAL OF PHYSIOLOGY-LONDON, 317 397-411 (1981)
Citations Scopus - 5Web of Science - 14
1979 BARRY PH, GAGE PW, VANHELDEN DF, 'CATION PERMEATION AT THE AMPHIBIAN MOTOR ENDPLATE', JOURNAL OF MEMBRANE BIOLOGY, 45 245-276 (1979)
DOI 10.1007/BF01869288
Citations Scopus - 9Web of Science - 22
1979 GAGE PW, HAMILL OP, VANHELDEN D, 'DUAL EFFECTS OF ETHER ON ENDPLATE CURRENTS', JOURNAL OF PHYSIOLOGY-LONDON, 287 353-369 (1979)
Citations Scopus - 7Web of Science - 13
1979 GAGE PW, VANHELDEN D, 'EFFECTS OF PERMEANT MONO-VALENT CATIONS ON ENDPLATE CHANNELS', JOURNAL OF PHYSIOLOGY-LONDON, 288 509-528 (1979)
Citations Scopus - 33Web of Science - 95
1979 KEYNES RD, MALACHOWSKI GC, VANHELDEN DF, 'EFFECT OF CALCIUM ON THE SODIUM GATING CURRENT IN THE SQUID GIANT-AXON', JOURNAL OF PHYSIOLOGY-LONDON, 295 P54-P55 (1979)
Citations Scopus - 1Web of Science - 4
1979 GAGE PW, HAMILL OP, VANHELDEN DF, BARRY PH, 'ACETYLCHOLINE RECEPTORS', MUSCLE & NERVE, 2 314-314 (1979)
1979 BARRY PH, GAGE PW, VANHELDEN DF, 'CATION PERMEATION THROUGH SINGLE MOTOR ENDPLATE CHANNELS', MUSCLE & NERVE, 2 314-314 (1979)
1979 VANHELDEN DF, GAGE PW, HAMILL OP, 'CONDUCTANCE OF ENDPLATE CHANNELS IS VOLTAGE DEPENDENT', NEUROSCIENCE LETTERS, 11 227-232 (1979)
DOI 10.1016/0304-3940(79)90133-2
Citations Scopus - 2Web of Science - 8
1979 BARRY PH, GAGE PW, VANHELDEN DF, 'ENDPLATE CHANNELS BEHAVE AS NEUTRAL SITE CHANNELS', NEUROSCIENCE LETTERS, 11 233-237 (1979)
DOI 10.1016/0304-3940(79)90134-4
Citations Scopus - 2Web of Science - 2
1978 GAGE PW, MCBURNEY RN, VANHELDEN D, 'OCTANOL REDUCES ENDPLATE CHANNEL LIFETIME', JOURNAL OF PHYSIOLOGY-LONDON, 274 279-298 (1978)
Citations Scopus - 17Web of Science - 50
1977 VANHELDEN D, HAMILL OP, GAGE PW, 'PERMEANT CATIONS ALTER ENDPLATE CHANNEL CHARACTERISTICS', NATURE, 269 711-713 (1977)
DOI 10.1038/269711a0
Citations Scopus - 17Web of Science - 47
1974 GAGE PW, MCBURNEY RN, VANHELDE D, 'ENDPLATE CURRENTS ARE SHORTENED BY OCTANOL - POSSIBLE ROLE OF MEMBRANE LIPID', LIFE SCIENCES, 14 2277-2283 (1974)
DOI 10.1016/0024-3205(74)90109-X
Citations Scopus - 9Web of Science - 39
Show 101 more journal articles

Conference (53 outputs)

Year Citation Altmetrics Link
2014 Sharafutdinova G, Holdsworth JL, Hosseini A, Vafa E, van Helden D, 'Investigating a New Volume Scanner', Proceedings of 2013 Australian and New Zealand Conference on Optics and Photonics, Fremantle, W.A. (2014) [E1]
Co-authors John Holdsworth, Galiya Sharafutdinova
2014 Walweel KD, vanHelden DF, Imtiaz MS, Dos Remedios C, Molenaar P, Laver DR, 'Inhibition of RyR2 from Failing and Non-Failing Human Hearts by Calmodulin', BIOPHYSICAL JOURNAL, San Francisco, CA (2014) [E3]
Co-authors Derek Laver
2014 Lazarte I, Sharafutdinova G, Holdsworth JL, van Helden D, van Helden D, 'A Novel Scanner For Diffuse Media Imaging', Abstracts. AIP Congress 2014, ANU (2014) [E3]
Co-authors Galiya Sharafutdinova, John Holdsworth
2013 Sharafutdinova G, Hosseini A, Holdsworth JL, van Helden D, 'Investigating A New Volume Scanner', ANZCOP 2013, Fremantle, WA (2013) [E3]
Co-authors Galiya Sharafutdinova
2013 Van Heiden DF, Laver DR, Imtiaz MS, Hashitani H, 'Cellular Interactions Controlling Tonic and Peristaltic Contractions of Gastric Smooth Muscle', JOURNAL OF PHYSIOLOGICAL SCIENCES (2013) [E3]
Co-authors Derek Laver
2012 Imtiaz MS, Van Helden DF, Laver DR, 'Three-dimensional modeling of Ca2+ dynamics in single cardiac cells', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authors Derek Laver
2012 Imtiaz MS, Allen DG, Van Helden DF, Laver DR, 'Role of intracellular Ca2+ in sinoatrial node pacemaking', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authors Derek Laver
2012 Mehra DR, Van Helden DF, Laver DR, 'Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authors Derek Laver
2012 Walweel K, Beard NA, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of human RYR2 by intracellular Ca2+ and Mg2+', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authors Derek Laver
2012 Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Citations Scopus - 9Web of Science - 6
Co-authors Derek Laver, Rick Thorne
2012 Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation alters RyR2 regulation by Ca2+ and Mg2+', Heart, Lung and Circulation: Abstracts of ISHR Auckland Workshop, Auckland, NZ (2012) [E3]
Co-authors Rick Thorne, Derek Laver
2011 Holdsworth JL, Sharafutdinova G, Sanderson MJ, Van Helden DF, 'Off-axis parabolic optical relays: almost perfect imaging', Proceedings of SPIE: 22nd Congress of the International Commission for Optics: Light for the Development of the World, Puebla, Mexico (2011) [E1]
DOI 10.1117/12.903430
Co-authors John Holdsworth, Galiya Sharafutdinova
2011 Li J, Beard NA, Dulhunty AF, vanHelden DF, Laver DR, 'The Effect of Adrenergic Stimulation on the Calcium Release Channel', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
2011 Laver DR, vanHelden DF, 'Tetracaine Inhibits RyRs by Three Mechanisms', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
2011 Mehra DR, vanHelden DF, Knollmann BC, Laver DR, 'Inhibition of Cardiac Ca2+ Release Channels by Class I Anti Arrhythmic Drugs as Therapy for Arrhythmia', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
2011 Walweel K, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of RyRs by intracellular Ca2+ and Mg2+ compared in sheep, rat and human heart', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
Co-authors Derek Laver
2011 Mehra DR, Van Helden DF, Hwang HS, Knollmann B, Laver DR, 'Role of cardiac Na+ channel blockers in inhibiting the cardiac calcium release channel', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
Co-authors Derek Laver
2010 Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'Calcium is a component of the signalling cascade leading to wall ingrowth formation in transfer cells', International Conference on Plant Vascular Biology 2010: PVB2010, Columbus, OH (2010) [E3]
Co-authors Tina Offler, David Mccurdy, John Patrick
2010 Gravina FS, Van Helden DF, De Oliveira R, Kerr KP, Jobling P, 'Relaxant effects of methanandamide unmasked by indomethacin in the mouse uterus', Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Melbourne, 2010, Melbourne, Vic (2010) [E3]
Co-authors Karen Kerr, Phillip Jobling
2010 Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Comparative scan engine field flatness', 19th Australian Institute of Physics Congress. Extended Abstracts and Refereed Full Papers, Melbourne, Vic (2010) [E1]
Co-authors John Holdsworth, Galiya Sharafutdinova
2010 Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'Signalling related to solute and hormone transport I', Plant Membrane Biology 15th International Workshop, Adelaide 2010: Programme & Abstracts, Adelaide, S.A. (2010) [E3]
Co-authors David Mccurdy, John Patrick, Tina Offler
2010 Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'A two-pore calcium channel is a component of the signalling cascade leading to wall ingrowth formation in transfer cells', Plant Membrane Biology 15th International Workshop, Adelaide 2010: Programme & Abstracts, Adelaide, S.A. (2010) [E3]
Co-authors David Mccurdy, Tina Offler, John Patrick
2009 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Ion channel modulation by reactive species in mice locus coeruleus neurons', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
Co-authors Alan Brichta, Robert Callister
2009 Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Intracellular calcium stores in mouse uterus: SR and Mitochondria', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
Co-authors Karen Kerr
2009 Gravina FS, Jobling P, Kerr KP, De Oliveira R, Van Helden DF, 'Identification of cannabinoid receptor 1 and the effect of methanandamide on uterine contractions of the mouse uterus', 1st National Symposium on Advances in Urogenital and Gut Research, Melbourne, VIC (2009) [E3]
Co-authors Karen Kerr, Phillip Jobling
2009 Hollins SL, Johnstone DM, Graham R, Van Helden DF, Kerr KP, Laver DR, et al., 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book, Porto, Portugal (2009) [E3]
Co-authors Rodney Scott, Derek Laver, Liz Milward, Karen Kerr
2009 Mehra DR, Van Helden DF, Knollmann B, Laver DR, 'Flecainide inhibits CPVT induced cardiac arrhythmias by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', 33rd Annual Meeting of the Australian Society for Biophysics: Program, Ballarat, VIC (2009) [E3]
Co-authors Derek Laver
2009 Kerr KP, Jobling P, Gravina FS, Van Helden DF, 'Contractility of the lower uterus and upper vagina in the mouse', 43rd ASCEPT Annual Scientific Meeting: Proceedings, Sydney, NSW (2009) [E3]
Co-authors Phillip Jobling, Karen Kerr
2009 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Effect of antioxidants in pacemaking of mice locus coeruleus neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Robert Callister, Alan Brichta
2009 Hollins SL, Johnstone DM, Van Helden DF, Kerr KP, Laver DR, Metelerkamp KM, et al., 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2009) [E3]
Co-authors Liz Milward, Derek Laver, Karen Kerr, Rodney Scott
2009 Van Helden DF, Imtiaz MS, Von Der Weid PY, ''Lymphatic hearts' - Are they really that primitive?', Journal of Vascular Research, Queenstown, NZ (2009) [E3]
2009 Sharafutdinova G, Holdsworth JL, Van Helden DF, 'A new scanner design for two-photon fluorescence fast imaging microscopy', Light in Life Sciences Conference 2009: Program, Melbourne, VIC (2009) [E3]
Co-authors Galiya Sharafutdinova, John Holdsworth
2009 Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Scan engine induced pulse broadening in two-photon microscopy', Nanophotonics Down Under 2009: Devices and Applications: Program, Melbourne, VIC (2009) [E2]
Co-authors John Holdsworth, Galiya Sharafutdinova
2009 Sharafutdinova G, Holdsworth JL, Legge SR, Van Helden DF, 'Comparative performance of four-mirror parabolic and spherical afocal relays', ACOLS ACOFT 09 Conference: Proceedings of the Australasian Conference on Optics, Lasers and Spectroscopy and Australian Conference on Optical Fibre Technology in Association, Adelaide, SA (2009) [E1]
Co-authors John Holdsworth, Galiya Sharafutdinova
2009 Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'The effect of volatile anaesthetics on the cardiac ryanodine receptor', Biophysical Journal, Boston, MA (2009) [E3]
Co-authors Tony Quail, Derek Laver
2009 Zhang H, Van Helden DF, McCurdy DW, Offler CE, Patrick JW, 'Calcium functions in the signalling cascade leading to wall ingrowth formation in transfer cells', ComBio 2009, Christchurch, NZ (2009) [E3]
Co-authors Tina Offler, David Mccurdy, John Patrick
2008 Gravina FS, Kerr KP, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Effects of the mitochondrial inhibitors CCCP, rotenone and CGP37157 on spontaneous contractions in the mouse uterus', Proceedings of the Australian Health and Medical Research Congress 2008, Brisbane, QLD (2008) [E3]
Co-authors Karen Kerr
2008 De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Influence of mitochondria in the interspike interval pacemaking currents of mice Locus Coeruleus neurons', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authors Robert Callister, Alan Brichta
2008 Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington HC, Imtiaz MS, Van Helden DF, 'Uterine spontaneous contractions in the estrous cycle and the effect of mitochondrial inhibitors', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authors Karen Kerr
2008 Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'Effect of volatile anaesthetics on the calcium release channel in the heart', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authors Derek Laver, Tony Quail
2008 Van Helden DF, Laver DR, Imtiaz MS, 'Ca2+ phase waves: A fundamental mechanism underlying propagation of gastric slow waves', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authors Derek Laver
2008 Imtiaz MS, Van Helden DF, 'Pacemaking in lymphatic smooth muscle', Journal of Vascular Research, Hamilton Island, QLD (2008) [E3]
2006 Hosaka K, Rayner SE, Von Der Weid PY, Zhao J, Imtiaz MS, Van Helden DF, 'Calcitonin gene-related peptide activates different signalling pathways in mesenteric lymphatics of the guinea pig', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Citations Scopus - 23
2005 van Helden DF, Hosaka K, Imtiaz MS, 'Lymphatic 'hearts' and their modulation by the endothelium', DRUG DEVELOPMENT RESEARCH, Shanghai, PEOPLES R CHINA (2005)
2005 Honen BN, Dalton RL, Van Helden DF, Laver DR, 'Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]
Co-authors Derek Laver
2004 Honen BN, Saint DA, Van Helden DF, Laver DR, 'The effects of fatty acids on SR calcium release channels from cardiac muscle', Biophysical Journal, Maryland, USA (2004) [E3]
Co-authors Derek Laver
2004 Krajniak SG, Callister RJ, Imtiaz MS, Brichta AM, Van Helden DF, 'Investigation of a brain rhythm', Proceedings of the Australian Neuroscience Society, Australia (2004) [E3]
Co-authors Alan Brichta, Robert Callister
1999 Van Helden DF, Imtiaz MS, Nurgaliyeva K, Von Der Weid P-Y, Dosen PJ, 'Evidence that Slow Waves in the Guinea-Pig Gastric Pylorus are Mediated by Inositol 1,4,5-Trisphosphate-Sensitive Ca2+ Release', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999 Imtiaz MS, Van Helden DF, 'A Mathematical Model of Depolarization-induced Slow Wave Action Potentials Arising by Intracellular Ca2+ Release from Inositol 1,4,5-Trisphosphate Sensitive Ca2+ Stores', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999 Zhao J, Gao J, Van Helden DF, 'The Effect of Neuropeptide Y on Vasomotion of Guinea-Pig Mesenteric Lymphatics', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999 Van Helden DF, Zhao J, 'Lymphatic Vasomotion', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1995 VANHELDEN DF, VONDERWEID PY, CROWE MJ, 'Electrophysiology of lymphatic smooth muscle', INTERSTITIUM, CONNECTIVE TISSUE AND LYMPHATICS, GLASGOW, SCOTLAND (1995)
Citations Web of Science - 12
1994 BERESFORDSMITH B, VANHELDEN DF, 'APPLICATIONS OF RADAR TRACKING ALGORITHMS TO MOTION ANALYSIS IN BIOMEDICAL IMAGES', ICIP-94 - PROCEEDINGS, VOL I, AUSTIN, TX (1994)
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Grants and Funding

Summary

Number of grants 87
Total funding $9,658,726

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $605,103

Regulation of RyR2 channels by calmodulin in healthy and diseased hearts$605,103

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1400064
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20143 grants / $105,240

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

Miltenyi Biotec GentleMACS Octo Dissociator with Heaters $23,566

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Darryl Knight, Professor Dirk Van Helden, Professor Joerg Mattes, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Associate Professor Liz Milward, Dr NATHAN Bartlett, Doctor Simon Keely, Doctor Steven Maltby, Doctor Andrew Jarnicki, Doctor Malcolm Starkey, Doctor Adam Collison, Ms Shaan Gellatly
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500861
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Vascular adaptation of the newborn: Hydrogen sulphide as a fundamental signalling molecule and novel target for therapy$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Ian Wright, Doctor Phil Jobling, Professor Dirk Van Helden
Scheme Near Miss Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301409
Type Of Funding Internal
Category INTE
UON Y

20138 grants / $505,229

HMRI MRSP Infrastructure (12-16) – CARDIOVASCULAR$255,777

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Dirk Van Helden, Professor Ronald Plotnikoff
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300589
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Nano-Optical Microscopy, Characterization and Fabrication Facility$155,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Andrew Fleming, Doctor John Holdsworth, Doctor Grant Webber, Professor Erich Kisi, Professor Dirk Van Helden
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200167
Type Of Funding Internal
Category INTE
UON Y

Towards a Mammography Scanner$13,287

Funding body: University of Newcastle - Faculty of Science & IT

Funding body University of Newcastle - Faculty of Science & IT
Project Team Doctor John Holdsworth, Doctor Galiya Sharafutdinova, Professor Dirk Van Helden
Scheme Strategic Initiative Research Fund (SIRF)
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1401036
Type Of Funding Internal
Category INTE
UON Y

Investigating the basis for diabetes-associated gastric motility disorders$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Associate Professor Derek Laver
Scheme Near Miss Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300485
Type Of Funding Internal
Category INTE
UON Y

Investigating the basis for diabetes-associated gastric motility disorders$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Dirk Van Helden
Scheme Near Miss
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300701
Type Of Funding Internal
Category INTE
UON Y

The 90th Annual Meeting of the Physiological Society of Japan, Tokyo 27-29 March 2013$1,569

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300979
Type Of Funding Internal
Category INTE
UON Y

20125 grants / $361,155

A novel approach to snakebite first aid$195,721

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden, Doctor Geoff Isbister
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100333
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure (11-12)- CARDIOVASCULAR$118,434

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Dirk Van Helden, Professor Ronald Plotnikoff
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1101118
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

First Aid for Cytotoxic Snakebite$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Dirk Van Helden, Doctor Geoff Isbister
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200154
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Gastric Slow Waves and Motility Disorders$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Associate Professor Derek Laver
Scheme Near Miss Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200674
Type Of Funding Internal
Category INTE
UON Y

International Conference to Celebrate the 50th Anniversary of Hungarian Society for Experimental and Clinical Pharmacology, Budpest, Hungary, 19 - 21 September 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200935
Type Of Funding Internal
Category INTE
UON Y

20111 grants / $536,706

Ryanodine receptor inhibitors as therapy for Ca2+ store overload induced arrhythmias$536,706

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
Scheme Project Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000274
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20103 grants / $135,196

HMRI MRSP Infrastructure Grant (10-11) - Cardiovascular$76,117

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Eugene Nalivaiko, Associate Professor Liz Milward, Professor Robert Callister, Professor Manohar Garg, Conjoint Professor Tony Quail
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1100525
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Effective anti-arrhythmic drugs: How do they work?$30,000

Funding body: BellBerry Limited

Funding body BellBerry Limited
Project Team Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
Scheme Near Miss
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900218
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000052
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20094 grants / $1,015,000

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189038
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Propagation and directionality of gastric slow waves$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Associate Professor Derek Laver
Scheme Near Miss Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189817
Type Of Funding Internal
Category INTE
UON Y

20084 grants / $87,144

The effects of iron status on calcium handling systems in heart and brain$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Derek Laver, Associate Professor Liz Milward, Professor Dirk Van Helden, Professor Rodney Scott
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188463
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188545
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Leica VT2100S Vibrating Microtome$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alan Brichta, Professor Robert Callister, Professor Dirk Van Helden, Associate Professor Philip Bolton, Doctor Rebecca Lim, Doctor Brett Graham, Dr Marcus Howlett, Doctor Angela McPherson, Doctor Mohammad Imtiaz, Doctor Ramatis De Oliveira, Mr Wayne Anderson, Mr Matthew Walsh
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188540
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

HMRI - Equipment Grant - High Speed Sensitivity CCD camera, centrifuge ELISA plate washer. etc$18,919

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Dirk Van Helden, Professor Manohar Garg
Scheme Equipment Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189386
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20075 grants / $1,159,256

HMRI - Cardiovascular Research Program$518,556

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Derek Laver, Conjoint Professor Tony Quail, Professor Dirk Van Helden, Professor Manohar Garg, Professor Robin Callister
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187946
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Cardiac Pacemaking$327,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0186436
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Rhythmicity and Synchronicity in Uterine Smooth Muscle$281,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden, Associate Professor Helena Parkington
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0186431
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
Scheme Equipment Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188196
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

5th International Symposium of Interstitial Cells of Cajal, Numore, Ireland, 20/8/2007 - 23/8/2007$1,700

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188167
Type Of Funding Internal
Category INTE
UON Y

20062 grants / $792,824

2006 Research Fellowship$776,824

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Research Fellowships
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0185119
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Mechanisms of action of w-3 fatty acids in control of atrial arrhythmias $16,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Derek Laver, Professor Dirk Van Helden, Doctor Bonny Honen
Scheme Project Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186102
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20054 grants / $254,500

INVESTIGATION OF A BRAIN RHYTHM$220,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
Scheme Discovery Projects
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184333
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

2005 RIBG allocation$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185808
Type Of Funding Internal
Category INTE
UON Y

Uterine Pacemaking$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184693
Type Of Funding Internal
Category INTE
UON Y

British Physiological Society Meeting: 4th International Mammalian Myocardium Symposium, 18-20 July 2005$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185646
Type Of Funding Internal
Category INTE
UON Y

20045 grants / $739,142

Cardiac Pacemaking$409,950

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0182936
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

High-Speed Confocal Microscope Live Cell Recording System$274,692

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183031
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

High-speed Confocal Microscope Live Cell Recording System$30,000

Funding body: University of New South Wales

Funding body University of New South Wales
Project Team Professor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta
Scheme Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183841
Type Of Funding Not Known
Category UNKN
UON Y

Investigation a brain rythym$14,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184506
Type Of Funding Internal
Category INTE
UON Y

HMRI Award for Research Excellence$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Dirk Van Helden
Scheme Sparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184891
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20036 grants / $96,000

Ratiometric Ion Imaging System.$30,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Dirk Van Helden
Scheme Major Equipment Award
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182194
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

CCD Camera: a Sub-Component for the High-Speed Confocal Microscope$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Equipment Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183064
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Mechanisms of action of omega-3 fatty acids in reduction of hypertension.$17,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Derek Laver, Professor Dirk Van Helden
Scheme Research Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182641
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Investigation of a Brain Rhythm$11,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Professor Robert Callister
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182443
Type Of Funding Internal
Category INTE
UON Y

Visit by Dr Kayoko Hosaka 1/07/03 to 30/06/04$5,600

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Visitor Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183266
Type Of Funding Internal
Category INTE
UON Y

British Physiological and Pharmacological Society Meeting. Manchester 9-12 Sept 2003$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183578
Type Of Funding Internal
Category INTE
UON Y

20022 grants / $34,315

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
Scheme Equipment Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181919
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Role of inositol 1,4,5-trisphosphate in cellular pacemaking$13,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Professor Judith Scott
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181329
Type Of Funding Internal
Category INTE
UON Y

200110 grants / $1,229,254

Rhythmicity, synchronicity and spasm in smooth muscle.$600,285

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0179698
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Rhythmicity, Synchronicity and Spasm in Smooth Muscle.$543,008

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Research Fellowships
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180718
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Till Photonics Polychrome II Monochromator$16,896

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Equipment Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181171
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Cardiac Pacemaking.$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180003
Type Of Funding Internal
Category INTE
UON Y

Mechanisms underlying cerebral vasospasm.$12,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Dirk Van Helden
Scheme Research Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0179768
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

The effect of Defocus on the Vascular and Lymphatic System of the Avian Choroid$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Doctor Sally McFadden, Dr Claudia Diaz
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180055
Type Of Funding Internal
Category INTE
UON Y

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
Scheme Equipment Grant
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0181178
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
Scheme University/NHMRC Equipment Grant Funds
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0181179
Type Of Funding Internal
Category INTE
UON Y

Till Photonics Polychrome II Monochromator$4,896

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme University/NHMRC Equipment Grant Funds
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181172
Type Of Funding Internal
Category INTE
UON Y

International Union of Physiological Sciences Congress 2001, New Zealand 26 August - 2 September 2001$1,629

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181433
Type Of Funding Internal
Category INTE
UON Y

20002 grants / $22,000

The Physiological Basis for Spasm in Blood and Lymphatic Vessels.$19,500

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden
Scheme Small Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178967
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Festschrift in honour of Professor Miriam Salpeter, USA 11-12 November 2000$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0180568
Type Of Funding Internal
Category INTE
UON Y

19991 grants / $1,896

ISSMETCS Symposium of Rhythmic activity in smooth muscle, Japan$1,896

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0180521
Type Of Funding Internal
Category INTE
UON Y

19986 grants / $358,411

The role of Calcium sparks in early muscle development$193,471

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden
Scheme Large Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177119
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Senior Brawn Research Support Fellowship.$80,000

Funding body: Gladys M Brawn Memorial Fellowships

Funding body Gladys M Brawn Memorial Fellowships
Project Team Professor Dirk Van Helden
Scheme Postdoctoral Research Fellowship
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0178626
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Vasomotion and Nerve-Induced Tone in the Smooth Muscle of Blood Vessels.$59,492

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Multi-Year Project Grant Scholarship
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177264
Type Of Funding Internal
Category INTE
UON Y

THE ACTION OF SNAKE VENOMS ON LYMPHATIC PUMPING$15,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Dirk Van Helden
Scheme Research Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177450
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Van Helden - Visit by Dr Kulmira B Nurgaliyeva$8,048

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden, Dulat Nurgaliyev
Scheme Visitor Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177540
Type Of Funding Internal
Category INTE
UON Y

18th World Congress of the International Union of Angiology, Tokyo, Japan$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0180618
Type Of Funding Internal
Category INTE
UON Y

19972 grants / $703,449

Pacemaking in Smooth Muscle.$700,949

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176261
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

XXXIII International Congress of Physiological Sciences, Russia, 30 June - 5 July 1997$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0179593
Type Of Funding Internal
Category INTE
UON Y

19962 grants / $91,092

Electrical pacemaking in smooth muscle.$49,092

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden
Scheme Multi-Year Small Grant Scholarship
Role Lead
Funding Start 1996
Funding Finish 1996
GNo G0175832
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Microscope and infra-red camera$42,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr Pankaj Sah, Dr B Walmsley, Emeritus Professor Peter Dunkley, Professor Dirk Van Helden
Scheme Equipment Grant
Role Investigator
Funding Start 1996
Funding Finish 1996
GNo G0175473
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

19951 grants / $2

The development of sensory innervation to blood vessels.$2

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Dirk Van Helden
Scheme Research Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0174698
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

19942 grants / $66,506

Role of Mast Cells in Smooth Muscle Spasm$44,983

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Dirk Van Helden
Scheme Multi-Year Small Grant Scholarship
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0174826
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Neurotransmitter release mechanism at the sympathetic neurovascular junction.$21,523

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr James Brock, Professor Dirk Van Helden
Scheme Project Grant
Role Investigator
Funding Start 1994
Funding Finish 1994
GNo G0173006
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

19934 grants / $595,740

Spontaneous Excitation in Lymphatic Smooth Muscle.$560,834

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0173196
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Control of Calcium in Neurones on the Dorsal Motor Nucleus of the Vagus.Refer A/c 43.200.948 no File opened refer s.rye 29/5/95$22,406

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr Pankaj Sah, Professor Dirk Van Helden
Scheme Project Grant
Role Investigator
Funding Start 1993
Funding Finish 1993
GNo G0173188
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Receptor Mechanisms Of Vascular Sensory Neurones$10,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Dirk Van Helden, Dr James Brock
Scheme Research Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0173272
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

'XXXII Intern. Union of Physiological Sciences', Glasgow, U.K. 1-6 Aug 1993, (b) 'Symposia on Autonomic Nervous System', Oxford Univ, UK,10-14 Aug 1993$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Travel Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0174390
Type Of Funding Internal
Category INTE
UON Y

19922 grants / $91,175

Role Of Sympathetic Nerves In The Development Of Hypertension$72,675

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Professor Dirk Van Helden
Scheme Grant-In-Aid
Role Lead
Funding Start 1992
Funding Finish 1992
GNo G0173714
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Mechanisms Of Activation Of Afferent Nerves On Blood Vessels$18,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 1992
Funding Finish 1992
GNo G0174237
Type Of Funding Internal
Category INTE
UON Y

19912 grants / $72,391

Receptor Mechanisms In Vascular Smooth Muscle$60,745

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Dirk Van Helden
Scheme Project Grant
Role Lead
Funding Start 1991
Funding Finish 1991
GNo G0173960
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Physiological Basis For Lymphatic Pumping$11,646

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Dirk Van Helden
Scheme Research Grant
Role Lead
Funding Start 1991
Funding Finish 1991
GNo G0173988
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y
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Research Supervision

Number of supervisions

Completed10
Current3

Total current UON EFTSL

PhD0.8

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Mechanosensitivity of TRPC6 Channels and its Role in Mechanoelectric Feedback of the Heart
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Effects of Calmodulin on Function of Cardiac Ryanodine Receptor
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD The Lymphatic Function in Diabetes
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2014 PhD Mechanisms of Cardiac Ryanodine Receptor Inhibition by Anti Arrhythmic Drugs
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Regulation of Calcium Release Channels (RyR2) in Healthy and Failing Human Hearts
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Regulation of Cardiac Calcium Release Channels During Acute Beta-Adrenergic Stimulation
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Contractile Properties of the Female Reproductive Tract
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2010 PhD Design and Investigation of a Four Mirror Scan Engine Incorporating Parabolic Reflectors
Physics, Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2010 PhD Pacemaking in Mouse Locus Coeruleus Neurons: Electrophysiological Properties, Role of Mitochondria and Development
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2006 PhD Biochemical Characterisation of the Human Transient Receptor Potential Channel, TRPC4
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2003 PhD The Effects of Specific Neurotransmitters on Vasomotion in Guinea-Pig Mesenteric Lymphatics
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
2003 PhD Distribution pacemaking through coupled oscillator-based mechanisms: A basis for long-range signalling in smooth muscle
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
2003 PhD Lymphatic Vasomotion
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
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Professor Dirk Van Helden

Position

Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Human Physiology

Contact Details

Email dirk.vanhelden@newcastle.edu.au
Phone (02) 4921 5623
Fax (02) 4921 7406

Office

Room MS405
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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