Professor Dirk Van Helden

Professor

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Investigations are being made on cellular rhythms including those in lymphatics, blood vessels, gastrointestinal tract, heart and specific mood-associated brain nuclei. We have discovered a new mechanism that it is driven by intracellular Ca2+ stores that allow groups of cells to self pace and hence become rhythmic. We are now exploring the relevance of this mechanism in a range of tissues. We are also interested in specific proteins involved in the pacemaker mechanism including inositol 1,4,5-trisphosphate receptors, ryanodine receptors, store operated calcium channels and TRP family proteins. These studies may influence future therapies to control lymphedema, digestive disorders, heart arrhythmias and brain mood states. We also have a recent patent relating to use of a topical ointment as a first aid treatment against snakebite. This was a surprising outcome that arose from studies investigating whether snake venoms enhance lymphatic pumping and hence accelerate their own delivery. Our preliminary trials indicate topical application of the ointment slows lymphatic transport by some 350% with no obvious adverse effects. The cream will be of particular use for bites to the torso where pressure bandaging is ineffective. It may also be useful as a first aid treatment against bites from other venomous creatures.

Research Expertise

Lymphatic and gastric pacemaking: Pacemaking in the lymphatic and gastric systems are the basis for our discovery of store pacemaking and calcium phase waves. We are now unravelling the finer details of these mechanisms. Importantly, as for all good research, there can often be unexpected yet important serendipitous outcomes. One in case is that this work has led to development of a first aid treatment against bites from venomous animals whose venoms transit the lymphatic system and we have a patent application on this finding under review.

Heart pacemaking: Traditionally, this has been considered to operate through a clock in the cell surface membrane of pacemaker cells. However, recent evidence from our pilot and modelling studies and from the work of others indicates a significant role of calcium stores. This introduces the possibility that the heart pacemaker model is only part of the story and that pacemaking involves an intracellular clock (i.e. store pacemaking). We are investigating this hypothesis, which if upheld will change the text book model for heart pacemaking and help change present understanding of specific heart disorders and their treatment.

(National Health and Medical Research Program Grant -NHMRC PG Cardiac Pacemaking, 2007-2009).

Brain rhythms: Brain rhythms function in most areas of the brain and while fundamental to life and our psyche remain poorly understood. We are testing the hypothesis that specific rhythms in the Locus Coeruleus, a brain stem nucleus known to be associated with mood states, are generated by store pacemaking. Evidence that the rhythms are generated by store pacemaking could provide a new framework for interpreting drug action in the treatment of mood disorders such as Bipolar Disorder.

(Australian Research Council Discovery Program Grant Investigation of a Brain Rhythm 2005-2007).

Uterine pacemaking: Astonishingly, there is still no clear understanding of the pacemaker mechanism that initiates and times uterine contractions. Pilot studies we have undertaken suggest this to be mediated by store pacemaking. Proof for this hypothesis would herald a mechanistic description for uterine contractions and may provide new insight into associated dysfunctions such as premature birth.

(NHMRC PG Rhythmicity and synchronicity in uterine smooth muscle, 2007-2009).



Teaching Expertise

Honours and Postgraduate students



Administrative Expertise

Research policy (e.g. Archetect of the Brawn Fellowship Scheme at the University of Newcastle)



Collaborations

Research Collaborations are being undertaken into:

1) Mechanisms underlying heart pacemaking with A/Prof Derek Laver, Prof Mark Boyett (Manchester University) and Prof Derek Terrar (Oxford University);

2) Gastrointestinal function Prof Hikaru Hashitani (Nagoya City University, Japan), Dr Bridget Southwell (Murdoch Children's Hospital) & Dr Costa Karihaloo (Lake Macquarrie Private Hospital);

3) Lymphatic function in health and disease ( Dr Mohammad Imtiaz and A/Prof Pierre Yves von der Weid (Calgary, Canada);

4) Spontaneous activity of the Locus coeruleus, a brain cell nucleus involved in establishement of attention and mood states (Dr Ramatis de Oliveira (Brazil), A/Prof Alan Brichta, Prof Robert Callister, Dr Rebecca Lim, Prof Janusz Lipski (Auckland), Mr Andrew Yee (Auckland).


Qualifications

  • PhD, University of New South Wales
  • Bachelor of Engineering, University of New South Wales

Keywords

  • Cellular physiologist
  • gastrointestinal physiology
  • heart pacemaking
  • neuroscience
  • smooth muscle

Fields of Research

CodeDescriptionPercentage
020599Optical Physics not elsewhere classified10
110399Clinical Sciences not elsewhere classified30
111699Medical Physiology not elsewhere classified60

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - 31/12/2015ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2001 - NHMRC Principal Research Fellow & Brawn Senior FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2001 - 1/12/2011Fellow NHMRC
NHMRC - Research Fellowships Scheme
University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1997 - Senior Brawn Fellowship
University of Newcastle - Gladys M. Brawn Fellowship Scheme
University of Newcastle
Australia
1/01/1990 - 1/12/2000NHMRC Senior Research Fellow
NHMRC - Research Fellowships Scheme
University of Newcastle
Australia

Membership

DatesTitleOrganisation / Department
Member - Australian Physiological SocietyAustralian Physiological Society
Australia
Member - The British Journal of PharmacologyWiley Online Library
Australia
Chair of the Research Committee - Cardiovascular GroupHunter Medical Research Institute (HMRI)
Australia
Faculty Member - Cardiovascular Physiology/Circulation of 'Faculty of 1000 Biology'Faculty of 1000
Australia
Member of Council - Australian Physiological SocietyAustralian Physiological Society
Australia
1/01/2001 - 31/12/2005Member of Editorial Board - the British Journal of PharmacologyWiley Online Library
Australia

Awards

Honours

YearAward
2012Honorary Member
Unknown
2007Sparke Helmore
Hunter Medical Research Institute

Recognition

YearAward
2013Adjunct Professor
Unknown

Invitations

External Reviewer - Departments

YearTitle / Rationale
2005Department of physiology
Organisation: University of Western Australia Description: Review RQF of the department for future planning

Participant

YearTitle / Rationale
2005calcium signaling
Organisation: Gordon conference Description: Invited speaker
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (101 outputs)

YearCitationAltmetricsLink
2015Nikolaev YA, Dosen PJ, Laver DR, Van Helden DF, Hamill OP, 'Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons', Brain Research, 1608 1-13 (2015)

The mammalian brain is a mechanosensitive organ that responds to different mechanical forces ranging from intrinsic forces implicated in brain morphogenesis to extrinsic forces that can cause concussion and traumatic brain injury. However, little is known of the mechanosensors that transduce these forces. In this study we use cell-attached patch recording to measure single mechanically-gated (MG) channel currents and their affects on spike activity in identified neurons in neonatal mouse brain slices. We demonstrate that both neocortical and hippocampal pyramidal neurons express stretch-activated MG cation channels that are activated by suctions of ~25 mm Hg, have a single channel conductance for inward current of 50-70 pS and show weak selectivity for alkali metal cations (i.e., Na+++). Significantly, single MG channel currents activated on the soma trigger spiking/action potentials in both neocortical and hippocampal pyramidal neurons. Not all neuron types studied here expressed MG channel currents. In particular, locus coeruleus and cerebellar Purkinje neurons showed no detectable MG channel activity. Moreover their robust rhythmic spike activity was resistant to mechanical modulation. Our observation that a single MG channel current can trigger spiking predicates the need for reassessment of the long held view that the impulse output of central neurons depends only upon their intrinsic voltage-gated channels and/or their integrated synaptic input.

DOI10.1016/j.brainres.2015.02.051
Co-authorsDerek Laver
2015Zhang H-M, Imtiaz MS, Laver DR, McCurdy DW, Offler CE, Van Helden DF, Patrick JW, 'Polarized and persistent Ca2+ plumes define loci for formation of wall ingrowth papillae in transfer cells', Journal of Experimental Botany, 66 1179-1190 (2015)

Transfer cell morphology is characterized by a polarized ingrowth wall comprising a uniform wall upon which wall ingrowth papillae develop at right angles into the cytoplasm. The hypothesis that positional information directing construction of wall ingrowth papillae is mediated by Ca2+ signals generated by spatiotemporal alterations in cytosolic Ca2+ ([Ca2+]cyt) of cells trans-differentiating to a transfer cell morphology was tested. This hypothesis was examined using Vicia faba cotyledons. On transferring cotyledons to culture, their adaxial epidermal cells synchronously trans-differentiate to epidermal transfer cells. A polarized and persistent Ca2+ signal, generated during epidermal cell trans-differentiation, was found to co-localize with the site of ingrowth wall formation. Dampening Ca2+ signal intensity, by withdrawing extracellular Ca2+ or blocking Ca2+ channel activity, inhibited formation of wall ingrowth papillae. Maintenance of Ca2+ signal polarity and persistence depended upon a rapid turnover (minutes) of cytosolic Ca2+ by co-operative functioning of plasma membrane Ca2+-permeable channels and Ca2+-ATPases. Viewed paradermally, and proximal to the cytosol-plasma membrane interface, the Ca2+ signal was organized into discrete patches that aligned spatially with clusters of Ca2+-permeable channels. Mathematical modelling demonstrated that these patches of cytosolic Ca2+ were consistent with inward-directed plumes of elevated [Ca2+]cyt. Plume formation depended upon an alternating distribution of Ca2+-permeable channels and Ca2+-ATPase clusters. On further inward diffusion, the Ca2+ plumes coalesced into a uniform Ca2+ signal. Blocking or dispersing the Ca2+ plumes inhibited deposition of wall ingrowth papillae, while uniform wall formation remained unaltered. A working model envisages that cytosolic Ca2+ plumes define the loci at which wall ingrowth papillae are deposited.

DOI10.1093/jxb/eru460
CitationsScopus - 1Web of Science - 3
Co-authorsDavid Mccurdy, John Patrick, Derek Laver
2015Beard DJ, McLeod DD, Logan CL, Murtha LA, Imtiaz MS, van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke.', J Cereb Blood Flow Metab, 35 861-872 (2015)
DOI10.1038/jcbfm.2015.2Author URL
Co-authorsNeil Spratt, Damian Mcleod
2015Beard DJ, Mcleod DD, Logan CL, Murtha LA, Imtiaz MS, Van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 35 861-872 (2015)

Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite stable arterial occlusion. The cause for 'collateral failure' is unknown. We recently showed that intracranial pressure (ICP) rises dramatically but transiently 24 hours after even minor experimental stroke. We hypothesized that ICP elevation would reduce collateral blood flow. First, we investigated the regulation of flow through collateral vessels and the penetrating arterioles arising from them during stroke reperfusion. Wistar rats were subjected to intraluminal middle cerebral artery (MCA) occlusion (MCAo). Individual pial collateral and associated penetrating arteriole blood flow was quantified using fluorescent microspheres. Baseline bidirectional flow changed to MCA-directed flow and increased by >450% immediately after MCAo. Collateral diameter changed minimally. Second, we determined the effect of ICP elevation on collateral and watershed penetrating arteriole flow. Intracranial pressure was artificially raised in stepwise increments during MCAo. The ICP increase was strongly correlated with collateral and penetrating arteriole flow reductions. Changes in collateral flow post-stroke appear to be primarily driven by the pressure drop across the collateral vessel, not vessel diameter. The ICP elevation reduces cerebral perfusion pressure and collateral flow, and is the possible explanation for 'collateral failure' in stroke-in-progression.

DOI10.1038/jcbfm.2015.2
Co-authorsNeil Spratt, Damian Mcleod
2015Beard DJ, Mcleod DD, Logan CL, Murtha LA, Imtiaz MS, Van Helden DF, Spratt NJ, 'Intracranial pressure elevation reduces flow through collateral vessels and the penetrating arterioles they supply. A possible explanation for 'collateral failure' and infarct expansion after ischemic stroke', Journal of Cerebral Blood Flow and Metabolism, 35 861-872 (2015)

Recent human imaging studies indicate that reduced blood flow through pial collateral vessels ('collateral failure') is associated with late infarct expansion despite stable arterial occlusion. The cause for 'collateral failure' is unknown. We recently showed that intracranial pressure (ICP) rises dramatically but transiently 24 hours after even minor experimental stroke. We hypothesized that ICP elevation would reduce collateral blood flow. First, we investigated the regulation of flow through collateral vessels and the penetrating arterioles arising from them during stroke reperfusion. Wistar rats were subjected to intraluminal middle cerebral artery (MCA) occlusion (MCAo). Individual pial collateral and associated penetrating arteriole blood flow was quantified using fluorescent microspheres. Baseline bidirectional flow changed to MCA-directed flow and increased by >450% immediately after MCAo. Collateral diameter changed minimally. Second, we determined the effect of ICP elevation on collateral and watershed penetrating arteriole flow. Intracranial pressure was artificially raised in stepwise increments during MCAo. The ICP increase was strongly correlated with collateral and penetrating arteriole flow reductions. Changes in collateral flow post-stroke appear to be primarily driven by the pressure drop across the collateral vessel, not vessel diameter. The ICP elevation reduces cerebral perfusion pressure and collateral flow, and is the possible explanation for 'collateral failure' in stroke-in-progression.

DOI10.1038/jcbfm.2015.2
Co-authorsDamian Mcleod, Neil Spratt
2015Nikolaev YA, Dosen PJ, Laver DR, van Helden DF, Hamill OP, 'Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons.', Brain Res, 1608 1-13 (2015)
DOI10.1016/j.brainres.2015.02.051Author URL
Co-authorsDerek Laver
2015Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR, 'Essential Role of Calmodulin in RyR Inhibition by Dantrolene.', Mol Pharmacol, 88 57-63 (2015)
DOI10.1124/mol.115.097691Author URL
Co-authorsDerek Laver
2014Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, et al., 'Differences in the regulation of RyR2 from human, sheep, and rat by Ca²¿ and Mg²¿ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.', J Gen Physiol, 144 263-271 (2014) [C1]
DOI10.1085/jgp.201311157Author URL
CitationsScopus - 2
Co-authorsDerek Laver, Tony Quail
2014van Helden DF, Thomas PA, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK, 'Pharmacological approaches that slow lymphatic flow as a snakebite first aid.', PLoS Negl Trop Dis, 8 e2722 (2014) [C1]
DOI10.1371/journal.pntd.0002722Author URL
Co-authorsDerek Laver, Geoff Isbister
2014Gravina FS, Van Helden DF, Kerr KP, De Oliveira RB, Jobling P, 'Phasic contractions of the mouse vagina and cervix at different phases of the estrus cycle and during late pregnancy', PLoS ONE, 9 (2014) [C1]

Conclusions/Significance: Cervical smooth muscle strips taken from mice in estrus, metestrus or late pregnancy were generally spontaneously active. Vaginal smooth muscle strips were normally quiescent but could be induced to exhibit phasic contractions independent on phase of the estrus cycle or late pregnancy. Spontaneous cervical or TEA-induced vaginal phasic contractions were not mediated by ICs or intracellular Ca2+ stores. Given that vaginal smooth muscle is normally quiescent then it is likely that increases in hormones such as oxytocin, as might occur through sexual stimulation, enhance the effectiveness of such pacemaking until phasic contractile activity emerges.

DOI10.1371/journal.pone.0111307
CitationsScopus - 1Web of Science - 2
Co-authorsKaren Kerr, Phillip Jobling
2014van Helden DF, 'The lymphangion: A not so 'primitive' heart', Journal of Physiology, 592 5353-5354 (2014) [C3]
DOI10.1113/jphysiol.2014.286039
2014Mehra D, Imtiaz MS, Van Helden DF, Knollmann BC, Laver DR, 'Multiple modes of ryanodine receptor 2 inhibition by flecainide', Molecular Pharmacology, 86 696-706 (2014) [C1]

Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na+ and RyR2 channels and prevents CPVT. The purpose of this study is to identify inhibitory mechanisms of flecainide on RyR2. RyR2 were isolated from sheep heart, incorporated into lipid bilayers, and investigated by singlechannel recording under various activating conditions, including the presence of cytoplasmic ATP (2mM) and a range of cytoplasmic [Ca2+], [Mg2+], pH, and [caffeine]. Flecainide applied to either the cytoplasmic or luminal sides of the membrane inhibited RyR2 by two distinct modes: 1) a fast block consisting of brief substate and closed events with a mean duration of ~1 ms, and 2) a slow block consisting of closed events with a mean duration of ~1 second. Both inhibition modes were alleviated by increasing cytoplasmic pH from 7.4 to 9.5 but were unaffected by luminal pH. The slow block was potentiated in RyR2 channels that had relatively low open probability, whereas the fast block was unaffected by RyR2 activation. These results show that these two modes are independent mechanisms for RyR2 inhibition, both having a cytoplasmic site of action. The slow mode is a closed-channel block, whereas the fast mode blocks RyR2 in the open state. At diastolic cytoplasmic [Ca2+] (100 nM), flecainide possesses an additional inhibitory mechanism that reduces RyR2 burst duration. Hence, multiple modes of action underlie RyR2 inhibition by flecainide.

DOI10.1124/mol.114.094623
CitationsScopus - 1Web of Science - 3
Co-authorsDerek Laver
2013Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR, 'ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.', PLoS One, 8 e58334 (2013) [C1]
DOI10.1371/journal.pone.0058334Author URL
Co-authorsRick Thorne, Derek Laver
2012De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1]
CitationsScopus - 1Web of Science - 1
Co-authorsRobert Callister, Alan Brichta, Rebecca Lim
2011De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1]
CitationsScopus - 3Web of Science - 3
Co-authorsAlan Brichta, Robert Callister, Rebecca Lim
2011Laver DR, Van Helden DF, 'Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels', Journal of Molecular and Cellular Cardiology, 51 357-369 (2011) [C1]
DOI10.1016/j.yjmcc.2011.05.009
CitationsScopus - 5Web of Science - 6
Co-authorsDerek Laver
2011Saul ME, Thomas PA, Dosen PJ, Isbister GK, O'Leary MA, Whyte IM, et al., 'A pharmacological approach to first aid treatment for snakebite', Nature Medicine, 17 809-811 (2011) [C1]
DOI10.1038/nm.2382
CitationsScopus - 15Web of Science - 16
Co-authorsGeoff Isbister, Sally Mcfadden
2011Gravina FS, Jobling P, Kerr KP, De Oliveira R, Parkington HC, Van Helden DF, 'Oxytocin depolarizes mitochondria in isolated myometrial cells', Experimental Physiology, 96 949-956 (2011) [C1]
DOI10.1113/expphysiol.2011.058388
CitationsScopus - 1Web of Science - 1
Co-authorsKaren Kerr, Phillip Jobling
2010Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Calculated two-photon fluorescence correction factors for reflective scan engines', Applied Optics, 49 1472-1479 (2010) [C1]
DOI10.1364/AO.49.001472
CitationsScopus - 1Web of Science - 1
Co-authorsJohn Holdsworth, Galiya Sharafutdinova
2010Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Improved field scanner incorporating parabolic optics. Part 2: experimental verification and potential for volume scanning', Applied Optics, 49 5517-5527 (2010) [C1]
DOI10.1364/AO.49.005517
CitationsScopus - 2Web of Science - 2
Co-authorsJohn Holdsworth, Galiya Sharafutdinova
2010Imtiaz MS, Von Der Weid P-Y, Van Helden DF, 'Synchronization of Ca2+oscillations: A coupled oscillator-based mechanism in smooth muscle', FEBS Journal, 277 278-285 (2010) [C1]
DOI10.1111/j.1742-4658.2009.07437.x
CitationsScopus - 13Web of Science - 11
2010Gravina FS, Parkington HC, Kerr KP, De Oliveira R, Jobling P, Coleman HA, et al., 'Role of mitochondria in contraction and pacemaking in the mouse uterus', British Journal of Pharmacology, 161 1375-1390 (2010) [C1]
DOI10.1111/j.1476-5381.2010.00949.x
CitationsScopus - 7Web of Science - 7
Co-authorsKaren Kerr, Phillip Jobling
2010Imtiaz MS, Von Der Weid P-Y, Laver DR, Van Helden DF, 'SR Ca2+ store refill-a key factor in cardiac pacemaking', Journal of Molecular and Cellular Cardiology, 49 412-426 (2010) [C1]
DOI10.1016/j.yjmcc.2010.03.015
CitationsScopus - 9Web of Science - 7
Co-authorsDerek Laver
2010De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
DOI10.1016/j.jneumeth.2010.03.029
CitationsScopus - 6Web of Science - 6
Co-authorsAlan Brichta, Brett Graham, Robert Callister, Rebecca Lim
2010Van Helden DF, Laver DR, Holdsworth JL, Imtiaz MS, 'Generation and propagation of gastric slow waves', Clinical and Experimental Pharmacology and Physiology, 37 516-524 (2010) [C1]
DOI10.1111/j.1440-1681.2009.05331.x
CitationsScopus - 20Web of Science - 17
Co-authorsJohn Holdsworth, Derek Laver
2010De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Pacemaker currents in mouse locus coeruleus neurons', Neuroscience, 170 166-177 (2010) [C1]
DOI10.1016/j.neuroscience.2010.06.028
CitationsScopus - 9Web of Science - 8
Co-authorsAlan Brichta, Robert Callister
2009Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Improved field scanner incorporating parabolic optics: Part 1: Simulation', Applied Optics, 48 4389-4396 (2009) [C1]
DOI10.1364/AO.48.004389
CitationsScopus - 5Web of Science - 5
Co-authorsGaliya Sharafutdinova, John Holdsworth
2009Imtiaz MS, von der Weid P-Y, Crowe M, van Helden D, 'Lymphatic pacemaking', FASEB JOURNAL, 23 (2009) [E3]
Author URL
2008Odell AF, Van Helden DF, Scott JL, 'The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels', Journal of Biological Chemistry, 283 4395-4407 (2008) [C1]
DOI10.1074/jbc.m709729200
CitationsScopus - 25Web of Science - 25
2008Von Der Weid P-Y, Rahman M, Imtiaz MS, Van Helden DF, 'Spontaneous transient depolarizations in lymphatic vessels of the guinea pig mesentery: Pharmacology and implication for spontaneous contractility', American Journal of Physiology: Heart and Circulatory Physiology, 295 H1989-H2000 (2008) [C1]
DOI10.1152/ajpheart.00007.2008
CitationsScopus - 21Web of Science - 17
2007Smith R, Van Helden DF, Hirst JJ, Zakar T, Read MA, Chan EC, et al., 'Pathological interactions with the timing of birth and uterine activation', Australian & New Zealand Journal of Obstetrics & Gynaecology, 47 430-437 (2007) [C1]
DOI10.1111/j.1479-828x.2007.00775.x
CitationsScopus - 8Web of Science - 8
Co-authorsJon Hirst, Hannah Palliser, Roger Smith
2007Imtiaz MS, Zhao J, Hosaka K, Von Der Weid PY, Crowe M, Van Helden DF, 'Pacemaking through Ca2+ stores interacting as coupled oscillators via membrane depolarization', Biophysical Journal, 92 3843-3861 (2007) [C1]
DOI10.1529/biophysj.106.095687
CitationsScopus - 22Web of Science - 20
2006Dielenberg R, Halasz P, Hosaka K, Van Helden DF, 'Vessel motion measurement in real-time using movement detection at multiple regions of interest', Journal of Neuroscience Methods, 152 40-47 (2006) [C1]
DOI10.1016/j.jneumeth.2005.08.005
CitationsScopus - 6Web of Science - 6
2006Hosaka K, Rayner SE, Von Der Weid PY, Zhao J, Imtiaz MS, Van Helden DF, 'Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs', American Journal of Physiology-Heart and Circulatory Physiology, 290 H813-H822 (2006) [C1]
DOI10.1152/ajpheart.00543.2005
CitationsWeb of Science - 18
2006Van Helden DF, Hosaka K, Imtiaz MS, 'Rhythmicity in the microcirculation', Clinical Hemorheology and Microcirculation, 34 59-66 (2006) [C1]
CitationsScopus - 8Web of Science - 6
2006Imtiaz MS, Katnik CP, Smith DW, Van Helden DF, 'Role of voltage-dependent modulation of store Ca2+ release in synchronization of Ca2+ oscillations', Biophysical Journal, 90 1-23 (2006) [C1]
DOI10.1529/biophysj.104.058743
CitationsScopus - 27Web of Science - 28
2005Odell AF, Scott JL, Van Helden DF, 'Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4', Journal of Biological Chemistry, 280 37974-37987 (2005) [C1]
DOI10.1074/jbc.M503646200
CitationsScopus - 67Web of Science - 65
2004Ferrusi I, Zhao J, Van Helden DF, Von Der Weid P-Y, 'Cyclopiazonic acid decreases spontaneous transient depolarizations in guinea pig mesenteric lymphatic vessels in endothelium-dependent and -independent manners', Am J Physiol Heart Circ Physiol, 286 H2287-H2295 (2004) [C1]
DOI10.1152/ajpheart.00739.2003
CitationsScopus - 11Web of Science - 11
2003Zhao J, Van Helden DF, 'ET-1-associated vasomotion and vasospasm in lymphatic vessels of the guinea-pig mesentery', British Journal of Pharmacology, 140 1399-1413 (2003) [C1]
DOI10.1038/sj.bjp.0705573
CitationsScopus - 16Web of Science - 16
2003Van Helden DF, Imtiaz MS, 'Ca2+ phase waves: a basis for cellular pacemaking and long-range synchronicity in the guinea-pig gastric pylorus', The Journal of Physiology, 548.1 271-296 (2003) [C1]
DOI10.1113/jphysiol.2002.033720
CitationsScopus - 66Web of Science - 62
2002Imtiaz MS, Smith DW, Van Helden DF, 'A Theoretical Model Of Slow Wave Regulation Using Voltage-Dependent Synthesis Of Inositol 1,4,5-Trisphosphate', Biophyhsical Journal, Vol. 83 1877-1890 (2002) [C1]
CitationsScopus - 28Web of Science - 28
2002Zhao J, Van Helden DF, 'ATP-induced endothelium-independent enhancement of lymphatic vasomotion in guinea-pig mesentery involves P2x and P2y receptors', British Journal of Pharmacology, 137 477-487 (2002) [C1]
CitationsScopus - 16Web of Science - 12
2001Von Der Weid P-Y, Zhao J, Van Helden DF, 'Nitric oxide decreases pacemaker activity in lymphatic vessels of guinea pig mesentery', Am J Physiol Heart Circ Physiol, 280 H2707-H2716 (2001) [C1]
CitationsScopus - 55Web of Science - 49
2000Van Helden DF, Imtiaz MS, Nurgaliyeva K, Von Der Weid P-Y, Dosen PJ, 'Role of calcium stores and membrane voltage in the generation of slow wave action potentials in guinea-pig gastric pylorus', Journal of Physiology, 524.1 245-265 (2000) [C1]
CitationsScopus - 104Web of Science - 100
2000Van Helden D, Zhao J, 'Lymphatic Vasomotion', Clinical and Experimental Pharmacology and Physiology, 27 1014-1018 (2000) [C1]
CitationsScopus - 19Web of Science - 16
1999Gao JN, Zhao J, Rayner SE, Van Helden DF, 'Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A(2)', BRITISH JOURNAL OF PHARMACOLOGY, 127 1597-1602 (1999)
DOI10.1038/sj.bjp.0702710Author URL
CitationsScopus - 29Web of Science - 27
1997Rayner SE, VanHelden DF, 'Evidence that the substance P-induced enhancement of pacemaking in lymphatics of the guinea-pig mesentery occurs through endothelial release of thromboxane A(2)', BRITISH JOURNAL OF PHARMACOLOGY, 121 1589-1596 (1997)
DOI10.1038/sj.bjp.0701306Author URL
CitationsScopus - 31Web of Science - 25
1997Crowe MJ, vonderWeid PY, Brock JA, VanHelden DF, 'Co-ordination of contractile activity in guinea-pig mesenteric lymphatics', JOURNAL OF PHYSIOLOGY-LONDON, 500 235-244 (1997)
Author URL
CitationsScopus - 33Web of Science - 28
1997vonderWeid PY, VanHelden DF, 'Functional electrical properties of the endothelium in lymphatic vessels of the guinea-pig mesentery', JOURNAL OF PHYSIOLOGY-LONDON, 504 439-451 (1997)
Author URL
CitationsScopus - 11Web of Science - 11
1996Oba T, Koshita M, Van Helden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers.', The American journal of physiology, 271 C819-C824 (1996)
1996Von der Weid PY, Van Helden DF, 'Beta-adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery.', The American journal of physiology, 270 H1687-H1695 (1996)
1996Brent PJ, Pang G, Little G, Dosen PJ, VanHelden DF, 'The sigma receptor ligand, reduced haloperidol, induces apoptosis and increases intracellular-free calcium levels [Ca2+](i) in colon and mammary adenocarcinoma cells', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 219 219-226 (1996)
DOI10.1006/bbrc.1996.0208Author URL
CitationsScopus - 44Web of Science - 39
1996Zipfel WR, OMalley JP, VanHelden D, Williams RM, Guild JB, Salpeter MM, Webb WW, 'Characterization of spontaneous calcium waves and sparks in primary cultures of fetal rat myotubes using two photon excitation point and line scanning microscopy.', BIOPHYSICAL JOURNAL, 70 WP283-WP283 (1996)
Author URL
CitationsWeb of Science - 2
1996Hashitani H, VanHelden DF, Suzuki H, 'Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra', BRITISH JOURNAL OF PHARMACOLOGY, 118 1627-1632 (1996)
Author URL
CitationsScopus - 92Web of Science - 92
1996vonderWeid PY, Crowe MJ, VanHelden DF, 'Endothelium-dependent modulation of pacemaking in lymphatic vessels of the guinea-pig mesentery', JOURNAL OF PHYSIOLOGY-LONDON, 493 563-575 (1996)
Author URL
CitationsScopus - 68Web of Science - 61
1996Stiles JR, VanHelden D, Bartol TM, Salpeter EE, Salpeter MM, 'Miniature endplate current rise times <100 mu s from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93 5747-5752 (1996)
DOI10.1073/pnas.93.12.5747Author URL
CitationsScopus - 118Web of Science - 113
1996Brock JA, VanHelden DF, Dosen P, Rush RA, 'Prevention of high blood pressure by reducing sympathetic innervation in the spontaneously hypertensive rat', JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 61 97-102 (1996)
DOI10.1016/S0165-1838(96)00063-XAuthor URL
CitationsScopus - 27Web of Science - 26
1996vonderWeid PY, VanHelden DF, 'beta-Adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery', AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 270 H1687-H1695 (1996)
Author URL
CitationsWeb of Science - 22
1996Von Der Weid P-Y, Van Helden DF, 'ß-Adrenoceptor-mediated hyperpolarization in lymphatic smooth muscle of guinea pig mesentery', American Journal of Physiology - Heart and Circulatory Physiology, 270 (1996)

Intracellular microelectrode recordings were performed to investigate the consequences of ß-adrenoceptor activation in smooth muscle of guinea pig mesenteric lymphatic vessels. Isoproterenol (Iso) hyperpolarized the membrane with an associated increase in membrane conductance and decreased the amplitude of spontaneous transient depolarizations. Iso effects were mimicked by forskolin (FSK), 3-isobutyl-1-methylxanthine, and two adenosine 3',5'- cyclic monophosphate (cAMP) derivatives. Iso- and FSK-induced hyperpolarizations were inhibited by H89, an inhibitor of cAMP-dependent protein kinase A, increased in K+-free solution, but were not affected by ouabain or by the nitric oxide synthase inhibitor N(¿)-nitro-L-arginine. They were partially inhibited by 20 mM tetraethylammonium (~40%) or by 2.5 mM 4-aminopyridine (~55%). The Iso-induced hyperpolarization was partially inhibited by iberiotoxin (20 nM) and charybdotoxin (40 nM), whereas the FSK- induced hyperpolarization was less affected. In cells where the Iso-induced hyperpolarization was decreased by 40 µM 1,2-bis(2-aminophenoxy)ethane- N,N,N',N'-tetraacetic acid, acetoxymethyl ester form, the FSK-induced hyperpolarization was little changed. Our results indicate that in guinea pig mesenteric lymphatic vessels, ß-adrenoceptor stimulation activates a protein kinase A-dependent K+ conductance, involving more than one channel type.

CitationsScopus - 26
1996Oba T, Koshita M, VanHelden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 271 C819-C824 (1996)
Author URL
CitationsWeb of Science - 26
1996Oba T, Koshita M, Van Helden DF, 'Modulation of frog skeletal muscle Ca2+ release channel gating by anion channel blockers', American Journal of Physiology - Cell Physiology, 271 (1996)

Effects of niflumic acid and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) on frog skeletal muscle ryanodine receptors have been studied by incorporating sarcoplasmic reticulum vesicles into planar lipid bilayers. Niflumic acid increased the mean open probability (P(o)) at 10 µM and decreased P(o) at 100 µM with no change in open time constants, unitary conductance, and reversal potential. The P(o) was augmented by DIDS at 5-200 µM without affecting either unitary conductance or reversal potential. DIDS induced a new third open time constant, probably contributing to a long- lived open state. Channels modified by niflumic acid or DIDS still responded to Ca2+ release channel modulators. These results provide evidence that niflumic acid and DIDS modify the gating mechanism of ryanodine receptors without affecting binding sites to the modulators and the physical pathway of the conducting pore. p-Chloromercuriphenyl sulfonic acid (pCMPS) transiently increased the P(o). The channel modified by DIDS responded to pCMPS, whereas that by ryanodine did not. The long open state of the channel induced by DIDS is produced by a quite different mechanism(s) from that by ryanodine. Contrary to cardiac ryanodine receptors, P(o) of skeletal muscle channels was independent of voltage after DIDS modification.

CitationsScopus - 26
1995BRENT PJ, DOSEN PJ, PANG G, VANHELDEN DF, 'THE SIGMA-BINDING SITE LIGAND, REDUCED HALOPERIDOL (RHAL), INCREASES INTRACELLULAR FREE CALCIUM LEVELS [CA2+]I IN COLON-CANCER CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S13-S13 (1995)
Author URL
1995BROCK JA, VANHELDEN DF, 'ENHANCED EXCITATORY JUNCTION POTENTIALS IN MESENTERIC-ARTERIES FROM SPONTANEOUSLY HYPERTENSIVE RATS', PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 430 901-908 (1995)
DOI10.1007/BF01837403Author URL
CitationsScopus - 46Web of Science - 44
1994BATES RC, BURET A, VANHELDEN DF, HORTON MA, BURNS GF, 'APOPTOSIS INDUCED BY INHIBITION OF INTERCELLULAR CONTACT', JOURNAL OF CELL BIOLOGY, 125 403-415 (1994)
DOI10.1083/jcb.125.2.403Author URL
CitationsScopus - 231Web of Science - 251
1993KLEMM MF, VANHELDEN DF, LUFF SE, 'ULTRASTRUCTURAL ANALYSIS OF SYMPATHETIC NEUROMUSCULAR-JUNCTIONS ON MESENTERIC VEINS OF THE GUINEA-PIG', JOURNAL OF COMPARATIVE NEUROLOGY, 334 159-167 (1993)
DOI10.1002/cne.903340113Author URL
CitationsScopus - 14Web of Science - 17
1993VANHELDEN DF, 'PACEMAKER POTENTIALS IN LYMPHATIC SMOOTH-MUSCLE OF THE GUINEA-PIG MESENTERY', JOURNAL OF PHYSIOLOGY-LONDON, 471 465-479 (1993)
Author URL
CitationsScopus - 107Web of Science - 106
1993BERESFORDSMITH B, NESBITT KV, VANHELDEN DF, 'EDGE-DETECTION AT MULTIPLE LOCATIONS USING A RADAR TRACKING ALGORITHM AS EXEMPLIFIED IN ISOLATED GUINEA-PIG LYMPHATIC VESSELS', JOURNAL OF NEUROSCIENCE METHODS, 49 69-79 (1993)
DOI10.1016/0165-0270(93)90110-DAuthor URL
CitationsScopus - 9Web of Science - 9
Co-authorsKeith Nesbitt
1991VANHELDEN DF, 'SPONTANEOUS AND NORADRENALINE-INDUCED TRANSIENT DEPOLARIZATIONS IN THE SMOOTH-MUSCLE OF GUINEA-PIG MESENTERIC VEIN', JOURNAL OF PHYSIOLOGY-LONDON, 437 511-541 (1991)
Author URL
CitationsScopus - 39Web of Science - 48
1990VANHELDEN DF, WOOLRIDGE S, 'ROLE OF NERVES IN HYPERTENSION', NATURE, 348 118-119 (1990)
DOI10.1038/348118b0Author URL
CitationsScopus - 4Web of Science - 7
1989VANHELDEN DF, 'NORADRENALINE-INDUCED TRANSIENT DEPOLARIZATIONS IN THE SMOOTH-MUSCLE OF ISOLATED GUINEA-PIG MESENTERIC LYMPHATICS', JOURNAL OF PHYSIOLOGY-LONDON, 418 P173-P173 (1989)
Author URL
CitationsWeb of Science - 6
1988VANHELDEN DF, 'ELECTROPHYSIOLOGY OF NEUROMUSCULAR-TRANSMISSION IN GUINEA-PIG MESENTERIC VEINS', JOURNAL OF PHYSIOLOGY-LONDON, 401 469-488 (1988)
Author URL
CitationsScopus - 19Web of Science - 32
1988VANHELDEN DF, 'AN ALPHA-ADRENOCEPTOR-MEDIATED CHLORIDE CONDUCTANCE IN MESENTERIC VEINS OF THE GUINEA-PIG', JOURNAL OF PHYSIOLOGY-LONDON, 401 489-501 (1988)
Author URL
CitationsWeb of Science - 46
1988Van Helden DF, 'An a-adrenoceptor-mediated chloride conductance in mesenteric veins of the guinea-pig', Journal of Physiology, 401 489-501 (1988)

1. The ionic basis of the depolarizing responses resulting from ionophoresis of noradrenaline onto the smooth muscle of mesenteric veins has been investigated using electrically short segments of vessel. 2. Isolated cut segments of vein were effectively isopotential as assessed by the voltage response to a step change in current. The mean input resistance and time constant of the smooth muscle were 24 MO and 131 ms respectively. 3. Data on the noradrenaline-induced slow depolarization indicated that it resulted from a decrease in conductance to potassium ions consistent with the finding of Suzuki (1981). 4. The fast noradrenaline-induced depolarization was found to have a reversal potential of about -22 mV. 5. Exposure to low-chloride solution caused greater than 90% suppression of this fast response with a 50% reduction occurring in less than 2 min. This suppression was not due to a negative shift in reversal potential. 6. The fast response underwent a large positive shift in reversal potential directly after changeover to low-chloride solution at times when any inactivation of the response was minimal. By contrast the fast response showed no evidence implicating either sodium or calcium as charge-carrying ions. 7. It is concluded that fast depolarization is carried by chloride ions.

CitationsScopus - 26
1986HIRST GDS, SILVERBERG GD, VANHELDEN DF, 'THE ACTION-POTENTIAL AND UNDERLYING IONIC CURRENTS IN PROXIMAL RAT MIDDLE CEREBRAL ARTERIOLES', JOURNAL OF PHYSIOLOGY-LONDON, 371 289-304 (1986)
Author URL
CitationsScopus - 31Web of Science - 84
1986HILL CE, HIRST GDS, SILVERBERG GD, VANHELDEN DF, 'SYMPATHETIC INNERVATION AND EXCITABILITY OF ARTERIOLES ORIGINATING FROM THE RAT MIDDLE CEREBRAL-ARTERY', JOURNAL OF PHYSIOLOGY-LONDON, 371 305-& (1986)
Author URL
CitationsScopus - 17Web of Science - 30
1985Hill CE, Hendry IA, Ngu MC, van Helden DF, 'Subpopulations of sympathetic neurones differ in their sensitivity to nerve growth factor antiserum.', Brain Research, 355 121-130 (1985)

Sympathetic postganglionic nerve fibres supplying mesenteric arteries and intrinsic ileal neurones differ in their characteristics of regeneration. Since the latter population of neurones occurs predominantly in prevertebral ganglia, which have been reported to be spared to some extent after treatment with antiserum to nerve growth factor (anti-NGF), we have investigated whether the two populations were differentially sensitive to anti-NGF. Newborn rats were treated daily for the first postnatal week with either anti-NGF or 154 mM NaCl solution. At 4 and 8 weeks of age, the presence of a functional sympathetic innervation to the mesenteric arteries and the gut was determined and correlated with the fluorescence histochemical demonstration of noradrenergic fibres. At both ages, stimulation of extrinsic sympathetic fibres caused an inhibition of gut motility, while the mesenteric arteries completely lacked a sympathetic innervation. Retrograde labelling of nerve cell bodies in control and antiserum treated rats confirmed that the sympathetic neurones supplying the ileal neurones were located in the prevertebral, superior mesenteric and coeliac ganglia and in the splanchnic ganglia lying along the greater splanchnic nerves. By interference from retrograde labelling in control animals, sympathetic neurones supplying the mesenteric arteries were present in all these ganglia, as well as in the thoracic and lumbar paravertebral sympathetic chains. The results suggest that two functionally distinct populations of sympathetic neurones, which overlap considerably in their distributions, are differentially sensitive to the immunological postnatal removal of NGF.

CitationsScopus - 16
1985HIRST GDS, DEGLERIA S, VANHELDEN DF, 'NEUROMUSCULAR-TRANSMISSION IN ARTERIOLES', EXPERIENTIA, 41 874-879 (1985)
DOI10.1007/BF01970004Author URL
CitationsScopus - 7Web of Science - 23
1985TAYLOR WM, VANDEPOL E, VANHELDEN DF, REINHART PH, BYGRAVE FL, 'EFFECT OF DEPOLARIZING CONCENTRATIONS OF POTASSIUM ON CALCIUM-UPTAKE AND METABOLISM IN RAT-LIVER', FEBS LETTERS, 183 70-74 (1985)
DOI10.1016/0014-5793(85)80956-XAuthor URL
CitationsScopus - 15Web of Science - 25
1985HIRST GDS, JOHNSON SM, VANHELDEN DF, 'THE CALCIUM CURRENT IN A MYENTERIC NEURON OF THE GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 361 297-314 (1985)
Author URL
CitationsScopus - 43Web of Science - 64
1985HIRST GDS, JOHNSON SM, VANHELDEN DF, 'THE SLOW CALCIUM-DEPENDENT POTASSIUM CURRENT IN A MYENTERIC NEURON OF THE GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 361 315-337 (1985)
Author URL
CitationsScopus - 94Web of Science - 128
1985HILL CE, HIRST GDS, NGU MC, VANHELDEN DF, 'SYMPATHETIC POSTGANGLIONIC REINNERVATION OF MESENTERIC-ARTERIES AND ENTERIC NEURONS OF THE ILEUM OF THE RAT', JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 14 317-334 (1985)
DOI10.1016/0165-1838(85)90079-7Author URL
CitationsScopus - 26Web of Science - 40
1985HILL CE, HENDRY IA, NGU MC, VANHELDEN DF, 'SUBPOPULATIONS OF SYMPATHETIC NEURONS DIFFER IN THEIR SENSITIVITY TO NERVE GROWTH-FACTOR ANTISERUM', DEVELOPMENTAL BRAIN RESEARCH, 23 121-130 (1985)
DOI10.1016/0165-3806(85)90011-2Author URL
CitationsScopus - 18Web of Science - 24
1984FINKEL AS, HIRST GDS, VANHELDEN DF, 'SOME PROPERTIES OF EXCITATORY JUNCTION CURRENTS RECORDED FROM SUBMUCOSAL ARTERIOLES OF GUINEA-PIG ILEUM', JOURNAL OF PHYSIOLOGY-LONDON, 351 87-98 (1984)
Author URL
CitationsScopus - 14Web of Science - 48
1983HILL CE, HIRST GDS, VANHELDEN DF, 'DEVELOPMENT OF SYMPATHETIC INNERVATION TO PROXIMAL AND DISTAL ARTERIES OF THE RAT MESENTERY', JOURNAL OF PHYSIOLOGY-LONDON, 338 129-147 (1983)
Author URL
CitationsScopus - 28Web of Science - 53
1983ARHEM P, VANHELDEN D, 'EFFECTS OF ALIPHATIC-ALCOHOLS ON MYELINATED NERVE MEMBRANE', ACTA PHYSIOLOGICA SCANDINAVICA, 119 105-107 (1983)
DOI10.1111/j.1748-1716.1983.tb07312.xAuthor URL
CitationsScopus - 4Web of Science - 8
1982HIRST GDS, VANHELDEN DF, 'IONIC BASIS OF THE RESTING POTENTIAL OF SUBMUCOSAL ARTERIOLES IN THE ILEUM OF THE GUINEA-PIG', JOURNAL OF PHYSIOLOGY-LONDON, 333 53-67 (1982)
Author URL
CitationsScopus - 32Web of Science - 63
1982GREEFF NG, KEYNES RD, VANHELDEN DF, 'FRACTIONATION OF THE ASYMMETRY CURRENT IN THE SQUID GIANT-AXON INTO INACTIVATING AND NON-INACTIVATING COMPONENTS', PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 215 375-389 (1982)
DOI10.1098/rspb.1982.0048Author URL
CitationsScopus - 7Web of Science - 42
1982KEYNES RD, GREEFF NG, VANHELDEN DF, 'THE RELATIONSHIP BETWEEN THE INACTIVATING FRACTION OF THE ASYMMETRY CURRENT AND GATING OF THE SODIUM-CHANNEL IN THE SQUID GIANT-AXON', PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 215 391-404 (1982)
DOI10.1098/rspb.1982.0049Author URL
CitationsScopus - 9Web of Science - 27
1981HARVEY AL, VANHELDEN DF, 'AGE-RELATED-CHANGES IN PROPERTIES OF ACETYLCHOLINE-RECEPTORS IN SINGLY AND MULTIPLY INNERVATED SKELETAL-MUSCLES OF THE CHICKEN', BRITISH JOURNAL OF PHARMACOLOGY, 74 P297-P298 (1981)
Author URL
1981HARVEY AL, VANHELDEN D, 'ACETYLCHOLINE-RECEPTORS IN SINGLY AND MULTIPLY INNERVATED SKELETAL-MUSCLE FIBERS OF THE CHICKEN DURING DEVELOPMENT', JOURNAL OF PHYSIOLOGY-LONDON, 317 397-411 (1981)
Author URL
CitationsScopus - 2Web of Science - 14
1979BARRY PH, GAGE PW, VANHELDEN DF, 'CATION PERMEATION AT THE AMPHIBIAN MOTOR ENDPLATE', JOURNAL OF MEMBRANE BIOLOGY, 45 245-276 (1979)
DOI10.1007/BF01869288Author URL
CitationsScopus - 4Web of Science - 22
1979GAGE PW, HAMILL OP, VANHELDEN D, 'DUAL EFFECTS OF ETHER ON ENDPLATE CURRENTS', JOURNAL OF PHYSIOLOGY-LONDON, 287 353-369 (1979)
Author URL
CitationsScopus - 6Web of Science - 13
1979GAGE PW, VANHELDEN D, 'EFFECTS OF PERMEANT MONO-VALENT CATIONS ON ENDPLATE CHANNELS', JOURNAL OF PHYSIOLOGY-LONDON, 288 509-528 (1979)
Author URL
CitationsScopus - 20Web of Science - 95
1979KEYNES RD, MALACHOWSKI GC, VANHELDEN DF, 'EFFECT OF CALCIUM ON THE SODIUM GATING CURRENT IN THE SQUID GIANT-AXON', JOURNAL OF PHYSIOLOGY-LONDON, 295 P54-P55 (1979)
Author URL
CitationsWeb of Science - 4
1979GAGE PW, HAMILL OP, VANHELDEN DF, BARRY PH, 'ACETYLCHOLINE RECEPTORS', MUSCLE & NERVE, 2 314-314 (1979)
Author URL
1979BARRY PH, GAGE PW, VANHELDEN DF, 'CATION PERMEATION THROUGH SINGLE MOTOR ENDPLATE CHANNELS', MUSCLE & NERVE, 2 314-314 (1979)
Author URL
1979VANHELDEN DF, GAGE PW, HAMILL OP, 'CONDUCTANCE OF ENDPLATE CHANNELS IS VOLTAGE DEPENDENT', NEUROSCIENCE LETTERS, 11 227-232 (1979)
DOI10.1016/0304-3940(79)90133-2Author URL
CitationsScopus - 1Web of Science - 8
1979BARRY PH, GAGE PW, VANHELDEN DF, 'ENDPLATE CHANNELS BEHAVE AS NEUTRAL SITE CHANNELS', NEUROSCIENCE LETTERS, 11 233-237 (1979)
DOI10.1016/0304-3940(79)90134-4Author URL
CitationsScopus - 2Web of Science - 2
1978GAGE PW, MCBURNEY RN, VANHELDEN D, 'OCTANOL REDUCES ENDPLATE CHANNEL LIFETIME', JOURNAL OF PHYSIOLOGY-LONDON, 274 279-298 (1978)
Author URL
CitationsScopus - 10Web of Science - 50
1977VANHELDEN D, HAMILL OP, GAGE PW, 'PERMEANT CATIONS ALTER ENDPLATE CHANNEL CHARACTERISTICS', NATURE, 269 711-713 (1977)
DOI10.1038/269711a0Author URL
CitationsScopus - 14Web of Science - 47
1974GAGE PW, MCBURNEY RN, VANHELDE D, 'ENDPLATE CURRENTS ARE SHORTENED BY OCTANOL - POSSIBLE ROLE OF MEMBRANE LIPID', LIFE SCIENCES, 14 2277-2283 (1974)
DOI10.1016/0024-3205(74)90109-XAuthor URL
CitationsScopus - 8Web of Science - 39
Show 98 more journal articles

Conference (53 outputs)

YearCitationAltmetricsLink
2014Sharafutdinova G, Holdsworth JL, Hosseini A, Vafa E, van Helden D, 'Investigating a New Volume Scanner', Proceedings of 2013 Australian and New Zealand Conference on Optics and Photonics, Fremantle, W.A. (2014) [E1]
Co-authorsJohn Holdsworth, Galiya Sharafutdinova
2014Walweel KD, vanHelden DF, Imtiaz MS, Dos Remedios C, Molenaar P, Laver DR, 'Inhibition of RyR2 from Failing and Non-Failing Human Hearts by Calmodulin', BIOPHYSICAL JOURNAL, San Francisco, CA (2014) [E3]
Author URL
Co-authorsDerek Laver
2014Lazarte I, Sharafutdinova G, Holdsworth JL, van Helden D, van Helden D, 'A Novel Scanner For Diffuse Media Imaging', Abstracts. AIP Congress 2014, ANU (2014) [E3]
Co-authorsGaliya Sharafutdinova, John Holdsworth
2013Sharafutdinova G, Hosseini A, Holdsworth JL, van Helden D, 'Investigating A New Volume Scanner', ANZCOP 2013, Fremantle, WA (2013) [E3]
Co-authorsGaliya Sharafutdinova
2013Van Heiden DF, Laver DR, Imtiaz MS, Hashitani H, 'Cellular Interactions Controlling Tonic and Peristaltic Contractions of Gastric Smooth Muscle', JOURNAL OF PHYSIOLOGICAL SCIENCES (2013) [E3]
Author URL
Co-authorsDerek Laver
2012Imtiaz MS, Van Helden DF, Laver DR, 'Three-dimensional modeling of Ca2+ dynamics in single cardiac cells', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDerek Laver
2012Imtiaz MS, Allen DG, Van Helden DF, Laver DR, 'Role of intracellular Ca2+ in sinoatrial node pacemaking', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDerek Laver
2012Mehra DR, Van Helden DF, Laver DR, 'Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDerek Laver
2012Walweel K, Beard NA, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of human RYR2 by intracellular Ca2+ and Mg2+', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDerek Laver
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
CitationsScopus - 6Web of Science - 6
Co-authorsDerek Laver, Rick Thorne
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation alters RyR2 regulation by Ca2+ and Mg2+', Heart, Lung and Circulation: Abstracts of ISHR Auckland Workshop, Auckland, NZ (2012) [E3]
Co-authorsRick Thorne, Derek Laver
2011Holdsworth JL, Sharafutdinova G, Sanderson MJ, Van Helden DF, 'Off-axis parabolic optical relays: almost perfect imaging', Proceedings of SPIE: 22nd Congress of the International Commission for Optics: Light for the Development of the World, Puebla, Mexico (2011) [E1]
DOI10.1117/12.903430
Co-authorsJohn Holdsworth, Galiya Sharafutdinova
2011Li J, Beard NA, Dulhunty AF, vanHelden DF, Laver DR, 'The Effect of Adrenergic Stimulation on the Calcium Release Channel', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
Author URL
2011Laver DR, vanHelden DF, 'Tetracaine Inhibits RyRs by Three Mechanisms', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
Author URL
2011Mehra DR, vanHelden DF, Knollmann BC, Laver DR, 'Inhibition of Cardiac Ca2+ Release Channels by Class I Anti Arrhythmic Drugs as Therapy for Arrhythmia', BIOPHYSICAL JOURNAL, Baltimore, MD (2011) [E3]
Author URL
2011Walweel K, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of RyRs by intracellular Ca2+ and Mg2+ compared in sheep, rat and human heart', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
Co-authorsDerek Laver
2011Mehra DR, Van Helden DF, Hwang HS, Knollmann B, Laver DR, 'Role of cardiac Na+ channel blockers in inhibiting the cardiac calcium release channel', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
Co-authorsDerek Laver
2010Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'Calcium is a component of the signalling cascade leading to wall ingrowth formation in transfer cells', International Conference on Plant Vascular Biology 2010: PVB2010, Columbus, OH (2010) [E3]
Co-authorsTina Offler, David Mccurdy, John Patrick
2010Gravina FS, Van Helden DF, De Oliveira R, Kerr KP, Jobling P, 'Relaxant effects of methanandamide unmasked by indomethacin in the mouse uterus', Australasian Society of Clinical and Experimental Pharmacology and Toxicology (ASCEPT) Annual Scientific Meeting, Melbourne, 2010, Melbourne, Vic (2010) [E3]
Co-authorsKaren Kerr, Phillip Jobling
2010Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Comparative scan engine field flatness', 19th Australian Institute of Physics Congress. Extended Abstracts and Refereed Full Papers, Melbourne, Vic (2010) [E1]
Co-authorsJohn Holdsworth, Galiya Sharafutdinova
2010Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'Signalling related to solute and hormone transport I', Plant Membrane Biology 15th International Workshop, Adelaide 2010: Programme & Abstracts, Adelaide, S.A. (2010) [E3]
Co-authorsDavid Mccurdy, John Patrick, Tina Offler
2010Zhang H, Van Helden DF, Offler CE, McCurdy DW, Patrick JW, 'A two-pore calcium channel is a component of the signalling cascade leading to wall ingrowth formation in transfer cells', Plant Membrane Biology 15th International Workshop, Adelaide 2010: Programme & Abstracts, Adelaide, S.A. (2010) [E3]
Co-authorsDavid Mccurdy, Tina Offler, John Patrick
2009De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Ion channel modulation by reactive species in mice locus coeruleus neurons', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
Co-authorsAlan Brichta, Robert Callister
2009Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Intracellular calcium stores in mouse uterus: SR and Mitochondria', Journal of Physiological Sciences, Kyoto, Japan (2009) [E3]
Co-authorsKaren Kerr
2009Gravina FS, Jobling P, Kerr KP, De Oliveira R, Van Helden DF, 'Identification of cannabinoid receptor 1 and the effect of methanandamide on uterine contractions of the mouse uterus', 1st National Symposium on Advances in Urogenital and Gut Research, Melbourne, VIC (2009) [E3]
Co-authorsKaren Kerr, Phillip Jobling
2009Hollins SL, Johnstone DM, Graham R, Van Helden DF, Kerr KP, Laver DR, et al., 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book, Porto, Portugal (2009) [E3]
Co-authorsRodney Scott, Derek Laver, Liz Milward, Karen Kerr
2009Mehra DR, Van Helden DF, Knollmann B, Laver DR, 'Flecainide inhibits CPVT induced cardiac arrhythmias by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', 33rd Annual Meeting of the Australian Society for Biophysics: Program, Ballarat, VIC (2009) [E3]
Co-authorsDerek Laver
2009Kerr KP, Jobling P, Gravina FS, Van Helden DF, 'Contractility of the lower uterus and upper vagina in the mouse', 43rd ASCEPT Annual Scientific Meeting: Proceedings, Sydney, NSW (2009) [E3]
Co-authorsPhillip Jobling, Karen Kerr
2009De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Effect of antioxidants in pacemaking of mice locus coeruleus neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsRobert Callister, Alan Brichta
2009Hollins SL, Johnstone DM, Van Helden DF, Kerr KP, Laver DR, Metelerkamp KM, et al., 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2009) [E3]
Co-authorsLiz Milward, Derek Laver, Karen Kerr, Rodney Scott
2009Van Helden DF, Imtiaz MS, Von Der Weid PY, ''Lymphatic hearts' - Are they really that primitive?', Journal of Vascular Research, Queenstown, NZ (2009) [E3]
2009Sharafutdinova G, Holdsworth JL, Van Helden DF, 'A new scanner design for two-photon fluorescence fast imaging microscopy', Light in Life Sciences Conference 2009: Program, Melbourne, VIC (2009) [E3]
Co-authorsGaliya Sharafutdinova, John Holdsworth
2009Sharafutdinova G, Holdsworth JL, Van Helden DF, 'Scan engine induced pulse broadening in two-photon microscopy', Nanophotonics Down Under 2009: Devices and Applications: Program, Melbourne, VIC (2009) [E2]
Co-authorsJohn Holdsworth, Galiya Sharafutdinova
2009Sharafutdinova G, Holdsworth JL, Legge SR, Van Helden DF, 'Comparative performance of four-mirror parabolic and spherical afocal relays', ACOLS ACOFT 09 Conference: Proceedings of the Australasian Conference on Optics, Lasers and Spectroscopy and Australian Conference on Optical Fibre Technology in Association, Adelaide, SA (2009) [E1]
Co-authorsJohn Holdsworth, Galiya Sharafutdinova
2009Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'The effect of volatile anaesthetics on the cardiac ryanodine receptor', Biophysical Journal, Boston, MA (2009) [E3]
Co-authorsTony Quail, Derek Laver
2009Zhang H, Van Helden DF, McCurdy DW, Offler CE, Patrick JW, 'Calcium functions in the signalling cascade leading to wall ingrowth formation in transfer cells', ComBio 2009, Christchurch, NZ (2009) [E3]
Co-authorsTina Offler, David Mccurdy, John Patrick
2008Gravina FS, Kerr KP, De Oliveira R, Parkington H, Imtiaz MS, Van Helden DF, 'Effects of the mitochondrial inhibitors CCCP, rotenone and CGP37157 on spontaneous contractions in the mouse uterus', Proceedings of the Australian Health and Medical Research Congress 2008, Brisbane, QLD (2008) [E3]
Co-authorsKaren Kerr
2008De Oliveira R, Howlett MC, Gravina FS, Imtiaz MS, Callister RJ, Brichta AM, Van Helden DF, 'Influence of mitochondria in the interspike interval pacemaking currents of mice Locus Coeruleus neurons', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authorsAlan Brichta, Robert Callister
2008Gravina FS, Kerr KP, Sandow S, De Oliveira R, Parkington HC, Imtiaz MS, Van Helden DF, 'Uterine spontaneous contractions in the estrous cycle and the effect of mitochondrial inhibitors', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authorsKaren Kerr
2008Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'Effect of volatile anaesthetics on the calcium release channel in the heart', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authorsTony Quail, Derek Laver
2008Van Helden DF, Laver DR, Imtiaz MS, 'Ca2+ phase waves: A fundamental mechanism underlying propagation of gastric slow waves', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authorsDerek Laver
2008Imtiaz MS, Van Helden DF, 'Pacemaking in lymphatic smooth muscle', Journal of Vascular Research, Hamilton Island, QLD (2008) [E3]
2006Hosaka K, Rayner SE, Von Der Weid PY, Zhao J, Imtiaz MS, Van Helden DF, 'Calcitonin gene-related peptide activates different signalling pathways in mesenteric lymphatics of the guinea pig', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
CitationsScopus - 23
2005van Helden DF, Hosaka K, Imtiaz MS, 'Lymphatic 'hearts' and their modulation by the endothelium', DRUG DEVELOPMENT RESEARCH, Shanghai, PEOPLES R CHINA (2005)
Author URL
2005Honen BN, Dalton RL, Van Helden DF, Laver DR, 'Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]
Co-authorsDerek Laver
2004Honen BN, Saint DA, Van Helden DF, Laver DR, 'The effects of fatty acids on SR calcium release channels from cardiac muscle', Biophysical Journal, Maryland, USA (2004) [E3]
Co-authorsDerek Laver
2004Krajniak SG, Callister RJ, Imtiaz MS, Brichta AM, Van Helden DF, 'Investigation of a brain rhythm', Proceedings of the Australian Neuroscience Society, Australia (2004) [E3]
Co-authorsRobert Callister, Alan Brichta
1999Van Helden DF, Imtiaz MS, Nurgaliyeva K, Von Der Weid P-Y, Dosen PJ, 'Evidence that Slow Waves in the Guinea-Pig Gastric Pylorus are Mediated by Inositol 1,4,5-Trisphosphate-Sensitive Ca2+ Release', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999Imtiaz MS, Van Helden DF, 'A Mathematical Model of Depolarization-induced Slow Wave Action Potentials Arising by Intracellular Ca2+ Release from Inositol 1,4,5-Trisphosphate Sensitive Ca2+ Stores', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999Zhao J, Gao J, Van Helden DF, 'The Effect of Neuropeptide Y on Vasomotion of Guinea-Pig Mesenteric Lymphatics', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1999Van Helden DF, Zhao J, 'Lymphatic Vasomotion', Proceedings of the Australian Physiological and Pharmacological Society, Newcastle, Australia (1999) [E2]
1995VANHELDEN DF, VONDERWEID PY, CROWE MJ, 'Electrophysiology of lymphatic smooth muscle', INTERSTITIUM, CONNECTIVE TISSUE AND LYMPHATICS, GLASGOW, SCOTLAND (1995)
Author URL
CitationsWeb of Science - 12
1994BERESFORDSMITH B, VANHELDEN DF, 'APPLICATIONS OF RADAR TRACKING ALGORITHMS TO MOTION ANALYSIS IN BIOMEDICAL IMAGES', ICIP-94 - PROCEEDINGS, VOL I, AUSTIN, TX (1994)
Author URL
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Grants and Funding

Summary

Number of grants85
Total funding$9,563,486

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $605,103

Regulation of RyR2 channels by calmodulin in healthy and diseased hearts$605,103

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400064
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20141 grants / $10,000

Vascular adaptation of the newborn: Hydrogen sulphide as a fundamental signalling molecule and novel target for therapy$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Ian Wright, Doctor Phil Jobling, Professor Dirk Van Helden
SchemeNear Miss Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301409
Type Of FundingInternal
CategoryINTE
UONY

20138 grants / $505,229

HMRI MRSP Infrastructure (12-16) – CARDIOVASCULAR$255,777

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Dirk Van Helden, Professor Ronald Plotnikoff
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300589
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Nano-Optical Microscopy, Characterization and Fabrication Facility$155,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Andrew Fleming, Doctor John Holdsworth, Doctor Grant Webber, Professor Erich Kisi, Professor Dirk Van Helden
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200167
Type Of FundingInternal
CategoryINTE
UONY

Towards a Mammography Scanner$13,287

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamDoctor John Holdsworth, Doctor Galiya Sharafutdinova, Professor Dirk Van Helden
SchemeStrategic Initiative Research Fund (SIRF)
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1401036
Type Of FundingInternal
CategoryINTE
UONY

Investigating the basis for diabetes-associated gastric motility disorders$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Associate Professor Derek Laver
SchemeNear Miss Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300485
Type Of FundingInternal
CategoryINTE
UONY

Investigating the basis for diabetes-associated gastric motility disorders$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Dirk Van Helden
SchemeNear Miss
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300701
Type Of FundingInternal
CategoryINTE
UONY

The 90th Annual Meeting of the Physiological Society of Japan, Tokyo 27-29 March 2013$1,569

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300979
Type Of FundingInternal
CategoryINTE
UONY

20125 grants / $361,155

A novel approach to snakebite first aid$195,721

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden, Doctor Geoff Isbister
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100333
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

HMRI MRSP Infrastructure (11-12)- CARDIOVASCULAR$118,434

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Dirk Van Helden, Professor Ronald Plotnikoff
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1101118
Type Of FundingOther Public Sector - State
Category2OPS
UONY

First Aid for Cytotoxic Snakebite$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Dirk Van Helden, Doctor Geoff Isbister
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200154
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Gastric Slow Waves and Motility Disorders$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Associate Professor Derek Laver
SchemeNear Miss Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200674
Type Of FundingInternal
CategoryINTE
UONY

International Conference to Celebrate the 50th Anniversary of Hungarian Society for Experimental and Clinical Pharmacology, Budpest, Hungary, 19 - 21 September 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200935
Type Of FundingInternal
CategoryINTE
UONY

20111 grants / $536,706

Ryanodine receptor inhibitors as therapy for Ca2+ store overload induced arrhythmias$536,706

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000274
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20103 grants / $135,196

HMRI MRSP Infrastructure Grant (10-11) - Cardiovascular$76,117

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Eugene Nalivaiko, Associate Professor Liz Milward, Professor Robert Callister, Professor Manohar Garg, Conjoint Professor Tony Quail
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1100525
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Effective anti-arrhythmic drugs: How do they work?$30,000

Funding body: BellBerry Limited

Funding bodyBellBerry Limited
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeNear Miss
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900218
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000052
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20094 grants / $1,015,000

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189038
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Propagation and directionality of gastric slow waves$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Associate Professor Derek Laver
SchemeNear Miss Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189817
Type Of FundingInternal
CategoryINTE
UONY

20084 grants / $87,144

The effects of iron status on calcium handling systems in heart and brain$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Associate Professor Liz Milward, Professor Dirk Van Helden, Professor Rodney Scott
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188463
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188545
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Leica VT2100S Vibrating Microtome$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alan Brichta, Professor Robert Callister, Professor Dirk Van Helden, Associate Professor Philip Bolton, Doctor Rebecca Lim, Doctor Brett Graham, Dr Marcus Howlett, Doctor Angela McPherson, Doctor Mohammad Imtiaz, Doctor Ramatis De Oliveira, Mr Wayne Anderson, Mr Matthew Walsh
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188540
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

HMRI - Equipment Grant - High Speed Sensitivity CCD camera, centrifuge ELISA plate washer. etc$18,919

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Dirk Van Helden, Professor Manohar Garg
SchemeEquipment Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189386
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20075 grants / $1,159,256

HMRI - Cardiovascular Research Program$518,556

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Conjoint Professor Tony Quail, Professor Dirk Van Helden, Professor Manohar Garg, Professor Robin Callister
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187946
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Cardiac Pacemaking$327,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186436
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Rhythmicity and Synchronicity in Uterine Smooth Muscle$281,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden, Associate Professor Helena Parkington
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186431
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
SchemeEquipment Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188196
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

5th International Symposium of Interstitial Cells of Cajal, Numore, Ireland, 20/8/2007 - 23/8/2007$1,700

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188167
Type Of FundingInternal
CategoryINTE
UONY

20062 grants / $792,824

2006 Research Fellowship$776,824

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeResearch Fellowships
RoleLead
Funding Start2006
Funding Finish2006
GNoG0185119
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Mechanisms of action of w-3 fatty acids in control of atrial arrhythmias $16,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Doctor Bonny Honen
SchemeProject Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186102
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20054 grants / $254,500

INVESTIGATION OF A BRAIN RHYTHM$220,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
SchemeDiscovery Projects
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184333
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

2005 RIBG allocation$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185808
Type Of FundingInternal
CategoryINTE
UONY

Uterine Pacemaking$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184693
Type Of FundingInternal
CategoryINTE
UONY

British Physiological Society Meeting: 4th International Mammalian Myocardium Symposium, 18-20 July 2005$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185646
Type Of FundingInternal
CategoryINTE
UONY

20045 grants / $739,142

Cardiac Pacemaking$409,950

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0182936
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

High-Speed Confocal Microscope Live Cell Recording System$274,692

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183031
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

High-speed Confocal Microscope Live Cell Recording System$30,000

Funding body: University of New South Wales

Funding bodyUniversity of New South Wales
Project TeamProfessor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183841
Type Of FundingNot Known
CategoryUNKN
UONY

Investigation a brain rythym$14,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Professor Robert Callister, Professor Alan Brichta
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184506
Type Of FundingInternal
CategoryINTE
UONY

HMRI Award for Research Excellence$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Dirk Van Helden
SchemeSparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184891
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20036 grants / $96,000

Ratiometric Ion Imaging System.$30,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Dirk Van Helden
SchemeMajor Equipment Award
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182194
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

CCD Camera: a Sub-Component for the High-Speed Confocal Microscope$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeEquipment Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183064
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Mechanisms of action of omega-3 fatty acids in reduction of hypertension.$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden
SchemeResearch Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182641
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Investigation of a Brain Rhythm$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Professor Robert Callister
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182443
Type Of FundingInternal
CategoryINTE
UONY

Visit by Dr Kayoko Hosaka 1/07/03 to 30/06/04$5,600

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeVisitor Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183266
Type Of FundingInternal
CategoryINTE
UONY

British Physiological and Pharmacological Society Meeting. Manchester 9-12 Sept 2003$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183578
Type Of FundingInternal
CategoryINTE
UONY

20022 grants / $34,315

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeEquipment Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181919
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Role of inositol 1,4,5-trisphosphate in cellular pacemaking$13,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Professor Judith Scott
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181329
Type Of FundingInternal
CategoryINTE
UONY

200110 grants / $1,229,254

Rhythmicity, synchronicity and spasm in smooth muscle.$600,285

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0179698
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Rhythmicity, Synchronicity and Spasm in Smooth Muscle.$543,008

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeResearch Fellowships
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180718
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Till Photonics Polychrome II Monochromator$16,896

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeEquipment Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181171
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Cardiac Pacemaking.$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180003
Type Of FundingInternal
CategoryINTE
UONY

Mechanisms underlying cerebral vasospasm.$12,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Dirk Van Helden
SchemeResearch Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0179768
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

The effect of Defocus on the Vascular and Lymphatic System of the Avian Choroid$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Doctor Sally McFadden, Dr Claudia Diaz
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180055
Type Of FundingInternal
CategoryINTE
UONY

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeEquipment Grant
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0181178
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
SchemeUniversity/NHMRC Equipment Grant Funds
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0181179
Type Of FundingInternal
CategoryINTE
UONY

Till Photonics Polychrome II Monochromator$4,896

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeUniversity/NHMRC Equipment Grant Funds
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181172
Type Of FundingInternal
CategoryINTE
UONY

International Union of Physiological Sciences Congress 2001, New Zealand 26 August - 2 September 2001$1,629

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181433
Type Of FundingInternal
CategoryINTE
UONY

20002 grants / $22,000

The Physiological Basis for Spasm in Blood and Lymphatic Vessels.$19,500

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden
SchemeSmall Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0178967
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Festschrift in honour of Professor Miriam Salpeter, USA 11-12 November 2000$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0180568
Type Of FundingInternal
CategoryINTE
UONY

19991 grants / $1,896

ISSMETCS Symposium of Rhythmic activity in smooth muscle, Japan$1,896

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0180521
Type Of FundingInternal
CategoryINTE
UONY

19986 grants / $358,411

The role of Calcium sparks in early muscle development$193,471

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden
SchemeLarge Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177119
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Senior Brawn Research Support Fellowship.$80,000

Funding body: Gladys M Brawn Memorial Fellowships

Funding bodyGladys M Brawn Memorial Fellowships
Project TeamProfessor Dirk Van Helden
SchemePostdoctoral Research Fellowship
RoleLead
Funding Start1998
Funding Finish1998
GNoG0178626
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Vasomotion and Nerve-Induced Tone in the Smooth Muscle of Blood Vessels.$59,492

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeMulti-Year Project Grant Scholarship
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177264
Type Of FundingInternal
CategoryINTE
UONY

THE ACTION OF SNAKE VENOMS ON LYMPHATIC PUMPING$15,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Dirk Van Helden
SchemeResearch Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177450
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Van Helden - Visit by Dr Kulmira B Nurgaliyeva$8,048

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Dulat Nurgaliyev
SchemeVisitor Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0177540
Type Of FundingInternal
CategoryINTE
UONY

18th World Congress of the International Union of Angiology, Tokyo, Japan$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start1998
Funding Finish1998
GNoG0180618
Type Of FundingInternal
CategoryINTE
UONY

19972 grants / $703,449

Pacemaking in Smooth Muscle.$700,949

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176261
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

XXXIII International Congress of Physiological Sciences, Russia, 30 June - 5 July 1997$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0179593
Type Of FundingInternal
CategoryINTE
UONY

19962 grants / $91,092

Electrical pacemaking in smooth muscle.$49,092

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden
SchemeMulti-Year Small Grant Scholarship
RoleLead
Funding Start1996
Funding Finish1996
GNoG0175832
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Microscope and infra-red camera$42,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDr Pankaj Sah, Dr B Walmsley, Emeritus Professor Peter Dunkley, Professor Dirk Van Helden
SchemeEquipment Grant
RoleInvestigator
Funding Start1996
Funding Finish1996
GNoG0175473
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

19951 grants / $2

The development of sensory innervation to blood vessels.$2

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Dirk Van Helden
SchemeResearch Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0174698
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

19942 grants / $66,506

Role of Mast Cells in Smooth Muscle Spasm$44,983

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden
SchemeMulti-Year Small Grant Scholarship
RoleLead
Funding Start1994
Funding Finish1994
GNoG0174826
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Neurotransmitter release mechanism at the sympathetic neurovascular junction.$21,523

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDr James Brock, Professor Dirk Van Helden
SchemeProject Grant
RoleInvestigator
Funding Start1994
Funding Finish1994
GNoG0173006
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

19934 grants / $595,740

Spontaneous Excitation in Lymphatic Smooth Muscle.$560,834

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start1993
Funding Finish1993
GNoG0173196
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Control of Calcium in Neurones on the Dorsal Motor Nucleus of the Vagus.Refer A/c 43.200.948 no File opened refer s.rye 29/5/95$22,406

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDr Pankaj Sah, Professor Dirk Van Helden
SchemeProject Grant
RoleInvestigator
Funding Start1993
Funding Finish1993
GNoG0173188
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Receptor Mechanisms Of Vascular Sensory Neurones$10,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Dirk Van Helden, Dr James Brock
SchemeResearch Grant
RoleLead
Funding Start1993
Funding Finish1993
GNoG0173272
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

'XXXII Intern. Union of Physiological Sciences', Glasgow, U.K. 1-6 Aug 1993, (b) 'Symposia on Autonomic Nervous System', Oxford Univ, UK,10-14 Aug 1993$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeTravel Grant
RoleLead
Funding Start1993
Funding Finish1993
GNoG0174390
Type Of FundingInternal
CategoryINTE
UONY

19922 grants / $91,175

Role Of Sympathetic Nerves In The Development Of Hypertension$72,675

Funding body: National Heart Foundation of Australia

Funding bodyNational Heart Foundation of Australia
Project TeamProfessor Dirk Van Helden
SchemeGrant-In-Aid
RoleLead
Funding Start1992
Funding Finish1992
GNoG0173714
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Mechanisms Of Activation Of Afferent Nerves On Blood Vessels$18,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start1992
Funding Finish1992
GNoG0174237
Type Of FundingInternal
CategoryINTE
UONY

19912 grants / $72,391

Receptor Mechanisms In Vascular Smooth Muscle$60,745

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden
SchemeProject Grant
RoleLead
Funding Start1991
Funding Finish1991
GNoG0173960
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Physiological Basis For Lymphatic Pumping$11,646

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamProfessor Dirk Van Helden
SchemeResearch Grant
RoleLead
Funding Start1991
Funding Finish1991
GNoG0173988
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Mechanosensitivity of TRPC6 Channels and its Role in Mechanoelectric Feedback of the Heart
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2012Effects of Calmodulin on Function of Cardiac Ryanodine Receptor
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2011The Lymphatic Function in Diabetes
Human Biology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014Mechanisms of Cardiac Ryanodine Receptor Inhibition by Anti Arrhythmic Drugs
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2014Regulation of Calcium Release Channels (RyR2) in Healthy and Failing Human Hearts
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2013Regulation of Cardiac Calcium Release Channels During Acute Beta-Adrenergic Stimulation
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2011Contractile Properties of the Female Reproductive Tract
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2010Design and Investigation of a Four Mirror Scan Engine Incorporating Parabolic Reflectors
Physics, Faculty of Science and Information Technology
Co-Supervisor
2010Pacemaking in Mouse Locus Coeruleus Neurons: Electrophysiological Properties, Role of Mitochondria and Development
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2006Biochemical Characterisation of the Human Transient Receptor Potential Channel, TRPC4
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2003The Effects of Specific Neurotransmitters on Vasomotion in Guinea-Pig Mesenteric Lymphatics
Human Biology, Faculty of Health and Medicine
Sole Supervisor
2003Distribution pacemaking through coupled oscillator-based mechanisms: A basis for long-range signalling in smooth muscle
Human Biology, Faculty of Health and Medicine
Sole Supervisor
2003Lymphatic Vasomotion
Human Biology, Faculty of Health and Medicine
Sole Supervisor
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Professor Dirk Van Helden

Position

Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Human Physiology

Contact Details

Emaildirk.vanhelden@newcastle.edu.au
Phone(02) 4921 5623
Fax(02) 4921 7406

Office

RoomMS405
BuildingMedical Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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