Staff Directory

Staff Profile

Career Summary

Biography

I obtained my BSc (Hons) and PhD in organic chemistry from the University of Strathclyde in Scotland. At the completion of my studies I took up a postdoctoral position at the University of Queensland in the area of reactive intermediates chemistry (spectroscopy at -261 ºC). After a 2 year stay, I changed research direction working alongside Professor Ron Quinn at Griffith University as a synthetic medicinal chemist. It was here I developed an interest in medicinal chemistry and teaching.

In December 1995 I was fortunate to secured a position as lecturer in organic chemistry at the University of Newcastle.

My team (the ones who do all the work) is responsible for >125 research publications and we have secured ~$25M in research funding since my arrival in Newcastle.

Qualifications

PhD, University of Strathclyde
Bachelor of Science (Honours), University of Strathclyde

Research

Research keywords

Anti-cancer agents
Anti-parastic agents
Chemical Biology
Clathrin Inhibitors
Drug Design and Discovery
Dynamin GTPase
Flow Chemistry
Organic Chemistry
Protein Phosphatase Inhibitors

Research expertise

Medicinal Chemistry;

* Inhibition of Protein Phosphatases as a therapeutic Strategy

* Inhibition of Dynamin GTPase

* Prevention of Pre-term delivery in Humans: Agonists & antagonists of Corticotrophin Releasing Hormone (CRH)

Green Chemistry;

Overarching Interest is in the application of organic chemistry strategies in the development of new therapeutic agents (Organic and Medicinal Chemistry). Additionally, given environmental and public concerns relating to Chemistry we are driven by a desire to develop Green Chemistry approaches in our organic and medicinal chemistry targets.

Emphasis is placed on solvent free reactions, atom efficiency, replacement of volatile organic solvents with environmentally friendly equivalents (ionic liquids), and evaluation of the most efficient synthetic routes to the desired end-points. My group's primary interests are in developing novel compounds with the ability to inhibit a number of signal transduction pathways.

The potential outcomes of our research include (but are not limited to) the development of new synthetic methodologies; the development of new drugs & the development of new tools for dissecting signal transduction pathways.

Fields of Research

Code	Description	Percentage
111599	Pharmacology And Pharmaceutical Sciences Not Elsewhere Classified	70
030400	Medicinal And Biomolecular Chemistry	30

Memberships

Editorial Board.

Editor - Medicinal Chemistry

Appointments

Honary Scientist
Children's Medical Research Institute (Australia)

01/01/2010

Awards

Recognition.

2005	Vice Chancellors Award for Teaching Excellence, Science & IT The University of Newcastle (Australia) Excellence in research is typically characterised by research publications and grant success. Excellence in teaching is less tangible, thus the recognition of both my peers and students via this award is of greater significance than all the research success to date. The greatest contribution to research comes via inspirational teaching and engendering a zest for learning and questioning. The receipt of this award indicates that I have been partly successful, which in turn has been reflected by the research successes attained. Good teaching inspires students, inspiring students conduct world class research.

2005

Vice Chancellors Award for Teaching Excellence, Science & IT
The University of Newcastle (Australia)
Excellence in research is typically characterised by research publications and grant success. Excellence in teaching is less tangible, thus the recognition of both my peers and students via this award is of greater significance than all the research success to date. The greatest contribution to research comes via inspirational teaching and engendering a zest for learning and questioning. The receipt of this award indicates that I have been partly successful, which in turn has been reflected by the research successes attained. Good teaching inspires students, inspiring students conduct world class research.

Collaboration

I am a teaching and research academic who believes that nurturing students and introducing to a positive research experience is one of the pillars of teaching at the University of Newcastle.

My research can be classified as either medicinal chemistry or chemical biology. I am known for the development of elegant approaches to highly focused compound libraries of biologically active compound. My team has established considerable corporate knowledge in the area of clathrin mediated endocytosis and its implications in neurological diseases, eg epilepsy. This led to the establishment of the dynamin modulators platform of which I am team leader (chemistry). This team interacts with, and supplies the only known endocytosis inhibitors to research teams worldwide (UK, USA, Germany, Denmark etc). I am also an integral component of the development of new anti-epileptic drugs alongside the National Institute of Health, National Institute of Neurological Disorders and Stroke (Bethesda USA).

I head the chemistry component of the Australian Cancer Research Foundation (supported by Ramaciotti) Centre for Kinomics (CFK), a new approach for direct profiling of cellular kinases, a multi-million dollar initiative providing a unique service to multiple research teams throughout Australia. Kinases are the cancer drug target of the 21st century. The CFK offers a unique opportunity to profile biological probes (drugs) and cellular kinases to identify new therapeutic targets, new uses for old drugs and rapid IC50 determination of individual compounds against the entire cellular kinome (cellular complement of protein kinases). The CFK at the University of Newcastle has established one of the first fully equipped flow chemistry laboratories in Australia comprising the ThalesNano H- and X-cube, the Syrris FRX and Syrris Africa work stations, and the VapourTech 4 pump -70 ºC unit. This facility is purpose built for the rapid optimisation of medicinal chemistry pathways and will significantly accelerate the initial optimisation phase of the UoN chemistry component of the multiple drug development pipelines initiated. I am also director of the University of Newcastle Priority Research Centre for Chemical Biology.

Teaching

Teaching keywords

Chemical Biology
Drug Design and Discovery
Organic Chemistry

Edit

Publications

No publications.

Edit

Grants and Funding

Summary

Number of grants	88
Total funding	$16,142,979

For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2013 (6 grants)

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$180,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Bogdan Dlugogorski, Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Scott Donne
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF)		Investigator
Total Amount	Funding Start	Funding Finish
$180,000	2013	2013
GNo:G1200569

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$175,000
Funding Body: University of Newcastle

Project Team
Professor Bogdan Dlugogorski, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Scott Donne, Professor Adam McCluskey
Scheme		Role
Equipment Grant		Investigator
Total Amount	Funding Start	Funding Finish
$175,000	2013	2013
GNo:G1200186

Multi-Centre Screening and Development Platform for Pre-Clinical Drugs for Glioblastoma$101,612
Funding Body: Cancer Council NSW

Project Team
Professor Phillip Robinson, Ms Megan Chircop, Professor Roger Reddel, Professor Adam McCluskey, Dr Jennette Sakoff
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$101,612	2013	2013
GNo:G1300989

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Pradeep Tanwar, Professor Eileen McLaughlin, Professor Xu Dong Zhang, Professor Robert Callister, Associate Professor Phillip Dickson, Professor Hubert Hondermarck, Doctor Jean-Marie Sontag, Professor Dirk Van Helden, Doctor Doug Smith, Doctor Phil Jobling, Associate Professor Estelle Sontag, Associate Professor Paul Tooney, Doctor Susan Hua, Doctor Janet Holt, Doctor Jay Horvat, Associate Professor Liz Milward, Professor Adam McCluskey, Associate Professor Brett Nixon, Doctor Rebecca Lim, Associate Professor Alan Brichta
Scheme		Role
Equipment Grant		Investigator
Total Amount	Funding Start	Funding Finish
$35,000	2013	2013
GNo:G1201185

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
Scheme		Role
Near Miss		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2013	2013
GNo:G1300700

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: University of Newcastle

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
Scheme		Role
Near Miss Grant		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2013	2013
GNo:G1300483

2012 (6 grants)

Mechanism Of Action Of Dynamin Ring Stabilizer Compounds Controlling The Actin Cytoskeleton $318,510
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phillip Robinson, Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$318,510	2012	2014
GNo:G1101104

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Ms Megan Chircop, Professor Adam McCluskey, Professor Phillip Robinson, Doctor Jennette Sakoff
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$245,100	2012	2014
GNo:G1101106

Bioaffinity mass spectrometry infrastructure to identify small molecules binding to therapeutic targets$125,000
Funding Body: University of Newcastle

Project Team
Professor Ronald Quinn, Associate Professor Sally-Ann Poulsen, Professor Ian Charles, Professor Adam McCluskey, Associate Professor Elizabeth Harry, Professor Johnson Mak
Scheme		Role
Equipment Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$125,000	2012	2012
GNo:G1100742

Identification of a novel target for the treatment of hormone positive breast cancer$30,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Dr Carole Gilbert, Professor Adam McCluskey
Scheme		Role
Breast Cancer Project Grant		Investigator
Total Amount	Funding Start	Funding Finish
$30,000	2012	2012
GNo:G1200716

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000
Funding Body: Trade and Investment NSW

Project Team
Professor Adam McCluskey, Doctor Jennette Sakoff
Scheme		Role
TechVouchers Program		Chief Investigator
Total Amount	Funding Start	Funding Finish
$15,000	2012	2012
GNo:G1200796

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge
Scheme		Role
Equipment Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2012	2012
GNo:G1100986

2011 (12 grants)

Chemical principles underpinning a spermostatic-microbiostatic agent capable of preventing pregnancy and the spread of sexually transmitted disease$735,000
Funding Body: ARC (Australian Research Council)

Project Team
Laureate Professor John Aitken, Doctor Mark Baker, Professor Kenneth Beagley, Professor Adam McCluskey
Scheme		Role
Discovery Projects		Investigator
Total Amount	Funding Start	Funding Finish
$735,000	2011	2013
GNo:G1000173

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Phillip Robinson, Professor Terence O'Brien, Ms Megan Chircop, Doctor Jennette Sakoff
Scheme		Role
Development Grants		Chief Investigator
Total Amount	Funding Start	Funding Finish
$544,831	2011	2013
GNo:G1000740

Establishment of a comprehensive regional biophysical analysis facility $500,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF)		Investigator
Total Amount	Funding Start	Funding Finish
$500,000	2011	2011
GNo:G1000630

Chemical Biology$444,961
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Doctor Warwick Belcher, Doctor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Conjoint Professor Ray Rose, Doctor Jennette Sakoff, Doctor Nikki Verrills
Scheme		Role
Priority Research Centre		Chief Investigator
Total Amount	Funding Start	Funding Finish
$444,961	2011	2015
GNo:G1100052

Sulfonadyn-based dynamin I-specific inhibitors and epilepsy$403,931
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Professor Phillip Robinson
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$403,931	2011	2013
GNo:G1100148

Establishment of a comprehensive regional biophysical analysis facility $230,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding		Investigator
Total Amount	Funding Start	Funding Finish
$230,000	2011	2011
GNo:G1100484

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$214,000
Funding Body: ARC (Australian Research Council)

Project Team
Dr Darren Trott, Professor Adam McCluskey, Mr Stephen Page
Scheme		Role
Linkage Projects		Chief Investigator
Total Amount	Funding Start	Funding Finish
$214,000	2011	2014
GNo:G1100855

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$147,500
Funding Body: Neoculi Pty Ltd

Project Team
Dr Darren Trott, Professor Adam McCluskey, Mr Stephen Page
Scheme		Role
Linkage Projects Partner funding		Chief Investigator
Total Amount	Funding Start	Funding Finish
$147,500	2011	2014
GNo:G1100918

Dynamin as a new drug target for the treatment of glioblastoma$96,000
Funding Body: Cancer Council NSW

Project Team
Professor Adam McCluskey
Scheme		Role
Research Program		Chief Investigator
Total Amount	Funding Start	Funding Finish
$96,000	2011	2013
GNo:G1100021

Development of clathrin inhibitors as novel endocytosis inhibitors$25,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Near Miss Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$25,000	2011	2011
GNo:G1001050

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
Scheme		Role
Equipment Grant		Investigator
Total Amount	Funding Start	Funding Finish
$15,000	2011	2011
GNo:G1100028

Restocking the Cupboard - Next generation Antibiotics$9,758
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Linkage Pilot Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$9,758	2011	2011
GNo:G1100043

2010 (9 grants)

Australian Cancer Research Foundation Cancer Research Grant$1,012,636
Funding Body: Australian Cancer Research Foundation

Project Team
Professor Adam McCluskey
Scheme		Role
Cancer Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$1,012,636	2010	2010
GNo:G1000006

Development of a humane non-surgical sterilization method for domestic animals$1,006,825
Funding Body: Found Animals Foundation Inc

Project Team
Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Adam McCluskey
Scheme		Role
Michelson Grants in Reproductive Biology		Investigator
Total Amount	Funding Start	Funding Finish
$1,006,825	2010	2012
GNo:G0900113

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Associate Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF)		Chief Investigator
Total Amount	Funding Start	Funding Finish
$500,000	2010	2010
GNo:G0190402

Streamlining the dynamin epilepsy drug pipeline$438,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Professor Phillip Robinson, Assoc. Prof Martin Larsen
Scheme		Role
Discovery Projects		Chief Investigator
Total Amount	Funding Start	Funding Finish
$438,000	2010	2012
GNo:G0190040

The 2009 Ramaciotti Major Initiative Biomedical Research Award$300,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Adam McCluskey
Scheme		Role
Major Initiative for Biomedical Research (Defunct)		Chief Investigator
Total Amount	Funding Start	Funding Finish
$300,000	2010	2010
GNo:G1000005

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Associate Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
Scheme		Role
Equipment Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$280,000	2010	2010
GNo:G1000873

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Professor Adam McCluskey, Associate Professor Brett Nixon, Professor John Rostas, Professor Eileen McLaughlin
Scheme		Role
Equipment Grant		Investigator
Total Amount	Funding Start	Funding Finish
$30,000	2010	2010
GNo:G1000051

Centre for Kinomics$25,000
Funding Body: John Morris Scientific Pty Ltd

Project Team
Professor Adam McCluskey
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$25,000	2010	2010
GNo:G1000614

The design of novel, affinity-based technology to specifically isolate phosphotyrosine-containing pedtides$25,000
Funding Body: Hunter Children`s Research Foundation

Project Team
Doctor Mark Baker, Professor Adam McCluskey
Scheme		Role
Research Grant		Investigator
Total Amount	Funding Start	Funding Finish
$25,000	2010	2010
GNo:G0900191

2009 (6 grants)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

Project Team
Laureate Professor John Aitken, Professor Adam McCluskey, Doctor Mark Baker, Doctor Nikki Verrills, Professor Marcel Maeder, Doctor Xiaojing Zhou, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Professor Ray Rose, Professor Hugh Dunstan, Professor Christopher Grof, Professor Roger Smith, Conjoint Professor Peter Gibson, Conjoint Professor Alison Jones, Professor Mike Calford, Conjoint Professor Keith Jones, Doctor Rick Thorne, Emeritus Professor Peter Dunkley, Professor Paul Foster, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Phillip Dickson, Professor John Rostas, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Phil Hansbro, Professor Pablo Moscato, Professor Paul Dastoor, Professor Peter Lewis
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF)		Investigator
Total Amount	Funding Start	Funding Finish
$495,000	2009	2009
GNo:G0189122

Development of dynamin inhibitors as novel therapies for epilepsy$306,001
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$306,001	2009	2011
GNo:G0190116

Preclinical new chemical entities as novel anti-epileptic drugs targeting dynamin$132,924
Funding Body: Epilepsy Foundation of America

Project Team
Professor Adam McCluskey
Scheme		Role
New Therapy Grants Program		Chief Investigator
Total Amount	Funding Start	Funding Finish
$132,924	2009	2010
GNo:G1000613

Dynamin as a new drug target for he treatment of glioblastoma$74,457
Funding Body: James S. McDonnell Foundation

Project Team
Professor Adam McCluskey, Ms Megan Chircop
Scheme		Role
Research Award		Chief Investigator
Total Amount	Funding Start	Funding Finish
$74,457	2009	2009
GNo:G0190466

Development of novel anti-epileptic drugs targeting vesicular endocytosis$66,200
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
Scheme		Role
Development Grants		Chief Investigator
Total Amount	Funding Start	Funding Finish
$66,200	2009	2009
GNo:G0190117

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

Project Team
Laureate Professor John Aitken, Professor Adam McCluskey, Doctor Mark Baker, Doctor Nikki Verrills, Professor Marcel Maeder, Doctor Xiaojing Zhou, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Professor Ray Rose, Professor Hugh Dunstan, Professor Christopher Grof, Professor Roger Smith, Conjoint Professor Peter Gibson, Conjoint Professor Alison Jones, Professor Mike Calford, Conjoint Professor Keith Jones, Doctor Rick Thorne, Emeritus Professor Peter Dunkley, Professor Paul Foster, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Phillip Dickson, Professor John Rostas, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Phil Hansbro, Professor Pablo Moscato, Professor Paul Dastoor, Professor Peter Lewis
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding		Investigator
Total Amount	Funding Start	Funding Finish
$50,000	2009	2009
GNo:G0189948

2008 (5 grants)

HMRI Cancer Research Program - MRSP Infrastructure$1,031,290
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Stephen Ackland, Conjoint Professor Leonie Ashman, Professor John Forbes, Conjoint Professor Jim Denham, Conjoint Professor Peter Hersey, Professor Gordon Burns, Professor Adam McCluskey, Doctor Nikki Verrills
Scheme		Role
MRSP Infrastructure Grant		Investigator
Total Amount	Funding Start	Funding Finish
$1,031,290	2008	2009
GNo:G0188622

Integrated surface fabrication and characterisation laboratory$750,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Paul Dastoor, Professor John O'Connor, Professor Bruce King, Professor Adam McCluskey, Doctor Warwick Belcher, Professor Catherine Stampfl, Dr Jeffrey Reimers, Assoc. Prof Alexander Hamilton, Dr Adam Micolich, Doctor Chris Fell, Dr Scott Watkins, Dr Mark Bown, Dr Anton Stampfl, Dr Peter Evans
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF)		Investigator
Total Amount	Funding Start	Funding Finish
$750,000	2008	2008
GNo:G0187931

The discovery and validation of novel drug classes against parasites of major economic importance$670,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Professor Robin Gasser, Dr Jennette Sakoff
Scheme		Role
Linkage Projects		Chief Investigator
Total Amount	Funding Start	Funding Finish
$670,000	2008	2010
GNo:G0187815

Partner contributions for Integrated surface fabrication and characterisation laboratory$320,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Paul Dastoor, Professor John O'Connor, Professor Bruce King, Professor Adam McCluskey, Doctor Warwick Belcher, Professor Catherine Stampfl, Dr Jeffrey Reimers, Assoc. Prof Alexander Hamilton, Dr Adam Micolich, Doctor Chris Fell, Dr Scott Watkins, Dr Mark Bown, Dr Anton Stampfl, Dr Peter Evans
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding		Investigator
Total Amount	Funding Start	Funding Finish
$320,000	2008	2008
GNo:G0189562

The discovery and validation of novel drug classes against parasites of major economic importance$270,000
Funding Body: Genetic Technologies Limited

Project Team
Professor Adam McCluskey, Professor Robin Gasser, Dr Jennette Sakoff
Scheme		Role
Linkage Projects Partner funding		Chief Investigator
Total Amount	Funding Start	Funding Finish
$270,000	2008	2010
GNo:G0188378

2007 (4 grants)

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$378,942
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer, Doctor Clovia Holdsworth, Professor Christopher Lennard
Scheme		Role
Linkage Projects		Chief Investigator
Total Amount	Funding Start	Funding Finish
$378,942	2007	2009
GNo:G0186611

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000
Funding Body: Entech Industries

Scheme		Role
Industry		Chief Investigator
Total Amount	Funding Start	Funding Finish
$105,000	2007	2007
GNo:17804791

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$105,000
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer, Doctor Clovia Holdsworth, Professor Christopher Lennard
Scheme		Role
Linkage Projects Partner funding		Chief Investigator
Total Amount	Funding Start	Funding Finish
$105,000	2007	2009
GNo:G0187330

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000
Funding Body: Entech Industries Pty Ltd

Project Team
Professor Adam McCluskey, Doctor Clovia Holdsworth, Associate Professor Michael Bowyer
Scheme		Role
Postgraduate Research Scholarship		Chief Investigator
Total Amount	Funding Start	Funding Finish
$105,000	2007	2010
GNo:G0187721

2006 (4 grants)

PRC - Priority Research Centre for Organic Electronics & OrganoBiosensors$549,282
Funding Body: University of Newcastle

Project Team
Professor Paul Dastoor, Professor Adam McCluskey, Professor Erica Wanless, Professor Scott Donne, Doctor John Holdsworth
Scheme		Role
Priority Research Centre		Investigator
Total Amount	Funding Start	Funding Finish
$549,282	2006	2013
GNo:G0186946

Consequences of Dynamin 2 PH Domain Dysfunction in Charcot-Marie-Tooth Neuropathy$217,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$217,500	2006	2008
GNo:G0186208

Chemical Interventions in Neurological Diseases?$20,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Near Miss Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$20,000	2006	2006
GNo:G0186050

BIT's 4th Annual Congress of International Drug Discovery Science & Technology 25 May - 2 June 2006$2,400
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Travel Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$2,400	2006	2006
GNo:G0186202

2005 (1 grants)

High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)

Project Team
Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Peter Lewis, Conjoint Associate Professor Renate Griffith, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Associate Professor David McCurdy, Professor Adam McCluskey, Emeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Professor John Rostas, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Professor Paul Foster, Conjoint Professor Peter Gibson, Professor Roger Smith, Professor Alistair Sim, Associate Professor Paul Tooney, Dr Fraser Ross
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF)		Investigator
Total Amount	Funding Start	Funding Finish
$207,189	2005	2005
GNo:G0184185

2004 (8 grants)

Selective detection and removal of contaminants that have an adverse impact on Australian raw sugar quality$190,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer, Dr M O'Shea
Scheme		Role
Linkage Projects		Chief Investigator
Total Amount	Funding Start	Funding Finish
$190,000	2004	2006
GNo:G0183626

Biacore3000-Expansion of Proteomics Facility$187,341
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
Scheme		Role
Linkage Infrastructure Equipment & Facilities (LIEF)		Investigator
Total Amount	Funding Start	Funding Finish
$187,341	2004	2004
GNo:G0183030

In-field sensors for the detection of illicit drugs$171,336
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
Scheme		Role
Linkage Projects		Chief Investigator
Total Amount	Funding Start	Funding Finish
$171,336	2004	2006
GNo:G0184254

Selective detection and removal of contaminants that have adverse impact on Australian raw sugar quality$51,000
Funding Body: Bureau of Sugar Experiment Stations

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
Scheme		Role
Linkage Projects Partner funding		Chief Investigator
Total Amount	Funding Start	Funding Finish
$51,000	2004	2006
GNo:G0184030

In-field sensors for the detection of illicit drugs$45,000
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
Scheme		Role
Linkage Projects Partner funding		Chief Investigator
Total Amount	Funding Start	Funding Finish
$45,000	2004	2006
GNo:G0185067

Improving Drug Development: New Approaches to Rapid Development of Novel Lead Compounds$27,542
Funding Body: Ramaciotti Foundations

Project Team
Professor Adam McCluskey
Scheme		Role
Major Equipment Award		Chief Investigator
Total Amount	Funding Start	Funding Finish
$27,542	2004	2004
GNo:G0183187

New drugs targeting protein kinases$17,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Leonie Ashman, Professor Adam McCluskey
Scheme		Role
Research Grant		Investigator
Total Amount	Funding Start	Funding Finish
$17,000	2004	2004
GNo:G0183751

Radiocarbon dating of heroin samples as a tool to verify the conversion to alternative crops.$5,820
Funding Body: AINSE (Australian Institute of Nuclear Science & Engineering)

Project Team
Professor Adam McCluskey
Scheme		Role
Use of Facilities Only		Chief Investigator
Total Amount	Funding Start	Funding Finish
$5,820	2004	2004
GNo:G0183703

2003 (4 grants)

Implementation of a Methamphetamine Method for the Australian Federal Police$230,309
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$230,309	2003	2005
GNo:G0184304

Dynamin inhibitors as tools for dissecting the endocytic pathways neurons$165,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$165,000	2003	2005
GNo:G0182859

High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Assoc. Prof David Young, Doctor Jennette Sakoff
Scheme		Role
Discovery Projects		Chief Investigator
Total Amount	Funding Start	Funding Finish
$50,000	2003	2003
GNo:G0182117

Implementation of a Methamphetamine Method for the Australian Federal Police$30,000
Funding Body: Australian Federal Police

Project Team
Professor Adam McCluskey
Scheme		Role
Equipment Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$30,000	2003	2003
GNo:G0184303

2002 (4 grants)

Antagonist of Corticotrophin Releasing Hormone as Therapeutic Agents for the Prevention of Premature Birth in Humans$375,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Adam McCluskey, Dr P Keller, Professor Roger Smith, Dr A Ruhmann
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$375,000	2002	2004
GNo:G0180905

Devevelopement and Use of Ionic Liquids in Metal Recovery from Ores, Concentrates and Mattes.$205,000
Funding Body: ARC (Australian Research Council)

Project Team
Emeritus Professor Geoffrey Lawrance, Dr I Hamilton, Professor Adam McCluskey
Scheme		Role
Discovery Projects		Investigator
Total Amount	Funding Start	Funding Finish
$205,000	2002	2004
GNo:G0181087

New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Conjoint Professor Stephen Ackland, Doctor Jennette Sakoff
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2002	2002
GNo:G0181459

Development of new therapeutic agents for the treatment of epilepsy$8,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$8,000	2002	2002
GNo:G0181460

2001 (4 grants)

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology.$30,268
Funding Body: Grape & Wine Research and Development Corporation

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$30,268	2001	2002
GNo:G0181473

Development of new drugs for the prevention of premature birth$10,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2001	2001
GNo:G0180062

Environmentally friendly ('Green') organic chemistry: Development of novel methodologies and reagents.$5,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$5,000	2001	2001
GNo:G0180014

92nd American Association for Cancer Research Annual Meeting, USA 24-28 March 2001$2,400
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Travel Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$2,400	2001	2001
GNo:G0180691

2000 (3 grants)

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology.$26,950
Funding Body: Grape & Wine Research and Development Corporation

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$26,950	2000	2000
GNo:G0180158

Synthesis of Drugs for Prevention of Pre-Term Delivery.$10,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Professor Roger Smith
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$10,000	2000	2000
GNo:G0178828

Towards Green Chemistry: The Development of Environmentally Organic Synthesis.$7,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$7,000	2000	2000
GNo:G0178827

1999 (5 grants)

Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jennette Sakoff, Professor Adam McCluskey, Conjoint Professor Stephen Ackland
Scheme		Role
Research Grant		Investigator
Total Amount	Funding Start	Funding Finish
$25,000	1999	1999
GNo:G0178390

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology$20,000
Funding Body: Grape & Wine Research and Development Corporation

Project Team
Professor Adam McCluskey, Associate Professor Michael Bowyer
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$20,000	1999	1999
GNo:G0178612

Rapid Microscale Synthesis of Drugs for the Prevention of Pre-Term Delivery$13,500
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Professor Roger Smith
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$13,500	1999	1999
GNo:G0178022

Development of a Versatile, Sensitive, Non-Isotopoic Method for Detecting Phosphorylated and Glycosylated Serines in Proteins and Peptides$10,000
Funding Body: University of Newcastle

Project Team
Professor John Rostas, Professor Adam McCluskey
Scheme		Role
Collaborative Research Grant		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	1999	1999
GNo:G0178350

RMC Collab Partner.Development of a Versatile, Sensitive, Non-Isotopic Method for Detecting Phosphorylated and Glucosylated Serines in Proteins & Peptides.$10,000
Funding Body: Bio-Rad Laboratories Pty Ltd (Australia)

Project Team
Professor John Rostas, Professor Adam McCluskey
Scheme		Role
Research Grant		Investigator
Total Amount	Funding Start	Funding Finish
$10,000	1999	1999
GNo:G0178764

1998 (3 grants)

Low molecular weight ligands for corticotrophin releasing hormone receptors: Drugs for intervention during human pregnancy$47,664
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey, Dr P Keller, Professor Roger Smith
Scheme		Role
Special Scholarship Initiative Grants		Chief Investigator
Total Amount	Funding Start	Funding Finish
$47,664	1998	2000
GNo:G0177742

Computer Modelling and Graphical Representation of the Three Dimensional Structure of Protein Phosphatases$9,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$9,000	1998	1998
GNo:G0177303

XVth EFMC International Symposium on Medicinal Chemistry, Scotland 6-10 September 1998$2,500
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Travel Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$2,500	1998	1998
GNo:G0180347

1997 (3 grants)

Computer Asisted Design and Chemical Synthesis of Novel Therapeutic Agents Affecting Pregnancy the Duration of Human Pregnancy$16,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Roger Smith, Professor Adam McCluskey, Professor Alan Boura
Scheme		Role
Small Grant		Investigator
Total Amount	Funding Start	Funding Finish
$16,000	1997	1997
GNo:G0176726

Design and Synthesis of Novel Corticotropin-Releasing Hormone Receptors Agaonists/Antagonists: Development of New Therapeutic Agents$15,000
Funding Body: Ramaciotti Foundations

Project Team
Professor Adam McCluskey, Ian Leitch
Scheme		Role
Research Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$15,000	1997	1997
GNo:G0176500

Development Of A Novel, Photolytic Oxidising Agent For Use In Synthetic Chemistry.$7,000
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
Project Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$7,000	1997	1997
GNo:G0176634

1996 (1 grants)

Design & Synthesis ofNovel Protein Phosphatase 1 & Protein Phosphatase 2A Inhibitors$12,500
Funding Body: University of Newcastle

Project Team
Professor Adam McCluskey
Scheme		Role
New Staff Grant		Chief Investigator
Total Amount	Funding Start	Funding Finish
$12,500	1996	1996
GNo:G0176326

Edit

Research Supervision

Number of current supervisions	11
Total current UoN PhD EFTSL	4.45

For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.

Current Supervision

Commenced	Proposed Completion	Program	Supervisor Type	Research Title
2013	2017	PhD (Biological Sciences)	Co-Supervisor	Consequences of Chronic Exposure of the Male Germ Line to Xenobiotics
2013	2017	PhD (Chemistry)	Principal Supervisor	Pathogenic Retroviruses - Developing Next Generation Antiviral Agents
2012	2016	PhD (Biological Sciences)	Principal Supervisor	Hedgehog Signaling Pathway Inhibitors as Cancer Suppressing Agents
2011	2015	PhD (Chemistry)	Principal Supervisor	A Chemical Biology Approach to Novel Inhibitors of Clathrin
2011	2015	PhD (Chemistry)	Principal Supervisor	Synthesis of Bolinaquinone Analogues as Clathrin Mediated Endocytosis
2010	2018	PhD (Medicine)	Co-Supervisor	The Characterisation and Classification of Residual Tool Marks on Bone Inflicted by Machetes and Samurai Swords (Sharp and Blunt) and the Survivability of Those Marks Following Thermal Trauma (Fire).
2010	2014	PhD (Chemistry)	Co-Supervisor	Synthesis of Regioregular Poly-3-Hexylthiophene Using Flow Chemistry for Incorporation into Organic Photo Voltaic Cells
2010	2014	PhD (Chemistry)	Principal Supervisor	Application of Green Chemistry Approaches to the Ugi and Passerini Multicomponent Reactions
2010	2014	PhD (Chemistry)	Co-Supervisor	Drugs from Nature: 1. Dynamin I Inhibitors from Mexican Marine Algae; 2. Chemical Investigation of an Australian Aboriginal Traditional Remedy
2007	2011	PhD (Chemistry)	Co-Supervisor	Exploring Signal Transduction Mechanisms in Molecularly Imprinted Polymers for Forensic Applications
2006	2010	PhD (Chemistry)	Sole Supervisor	Novel Inhibitors of Dynamin GTPase

Past Supervision

Year	Program	Supervisor Type	Research Title
2013	PhD (Chemistry)	Principal Supervisor	Synthesis and Evaluation of Norcantharidin and Acrylonitrile Derivatives as Potential Anti-Cancer Agents
2013	PhD (Chemistry)	Principal Supervisor	A Mechanistic Study into the Reaction Between Carbon Dioxide and Amines
2013	PhD (Chemistry)	Principal Supervisor	Design and Synthesis of Molecularly Imprinted Polymers for the Selective Extraction of Polychlorinated Biphenyls
2012	PhD (Chemistry)	Principal Supervisor	1. Dynamin-l Inhibitors from Sessile Marine Invertebrates; 2. Chemotaxonomy of Cystophora spp.
2012	PhD (Chemistry)	Principal Supervisor	Disruption of Clathrin Mediated-Endocytosis through Small Molecule Inhibition of Dynamin and Clathrin
2012	PhD (Chemistry)	Principal Supervisor	Synthesis, Characterisation and Evaluation of Biphenyl Monomers for Molecular Imprinting Applications
2011	M Philosophy (Chemistry)	Principal Supervisor	Novel Inhibitors of Clathrin Mediated Endocytosis
2010	PhD (Chemistry)	Co-Supervisor	Characterisation and Improved Performance of Molecularly Imprinted Polymers Prepared Using Room Temperature Ionic Liquids
2010	PhD (Chemistry)	Principal Supervisor	Optimisation of Molecularly Imprinted Polymeric Films for the Detection of L-Ephedrine
2010	PhD (Chemistry)	Co-Supervisor	Towards the Development of a Benzylpiperazine Specific Molecular Imprinted Polymer
2009	PhD (Chemistry)	Principal Supervisor	Norcantharidin Analogues: PP1 and PP2A Inhibition and Potential Therapeutic Development
2008	PhD (Chemistry)	Principal Supervisor	Design and Synthesis of Molecularly Imprinted Polymers for the Selective Recognition of Small Chloro-Arene Contaminants
2008	PhD (Chemistry)	Co-Supervisor	Ionic Liquids for Synthesis and Metal Recovery
2007	PhD (Chemistry)	Sole Supervisor	Design and Synthesis of Novel Dynamin GTPase Inhibitors
2006	PhD (Chemistry)	Co-Supervisor	New Routes To Precious Metal Recovery Using Ionic Liquids
2006	PhD (Chemistry)	Co-Supervisor	Ionic Liquids for Explosive Technologies
2006	PhD (Chemistry)	Sole Supervisor	Novel Inhibitors of Dynamin GTPase
2006	PhD (Chemistry)	Sole Supervisor	Cantharidin Analogues: Potential Therapeutic Agents
2005	PhD (Chemistry)	Co-Supervisor	Chemotaxonomy of the brown algal genus Cyclophoria
2004	PhD (Chemistry)	Sole Supervisor	Design and Synthesis of Potential CRHR1 Antagonists
2004	PhD (Chemistry)	Sole Supervisor	Development Towards Structurally Unprecedented Corticotropin Releasing Hormone Type-1 Receptor Antagonists

Edit

Professor Adam McCluskey

Work Phone	(02) 4921 6486
Fax	(02) 4921 5472
Email	Adam.McCluskey@newcastle.edu.au
Position	Professor School of Environmental and Life Sciences Faculty of Science and Information Technology The University of Newcastle, Australia
Focus Area	Chemistry
Office	C318, Chemistry, Callaghan University Drive Callaghan NSW 2308 Australia
URL:	www.newcastle.edu.au/profile/adam-mccluskey

Staff Directory

Staff Profile

Career Summary

Biography

Qualifications

Research

Research keywords

Research expertise

Fields of Research

Memberships

Editorial Board.

Appointments

Awards

Recognition.

Collaboration

Teaching

Teaching keywords

Publications

Grants and Funding

Summary

2013 (6 grants)

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$180,000Funding Body: ARC (Australian Research Council)

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$175,000Funding Body: University of Newcastle

Multi-Centre Screening and Development Platform for Pre-Clinical Drugs for Glioblastoma$101,612Funding Body: Cancer Council NSW

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000Funding Body: NHMRC (National Health & Medical Research Council)

Dynamin - role in sperm oocyte interaction$10,000Funding Body: Hunter Medical Research Institute

Dynamin - role in sperm oocyte interaction$10,000Funding Body: University of Newcastle

2012 (6 grants)

Mechanism Of Action Of Dynamin Ring Stabilizer Compounds Controlling The Actin Cytoskeleton $318,510Funding Body: NHMRC (National Health & Medical Research Council)

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100Funding Body: NHMRC (National Health & Medical Research Council)

Bioaffinity mass spectrometry infrastructure to identify small molecules binding to therapeutic targets$125,000Funding Body: University of Newcastle

Identification of a novel target for the treatment of hormone positive breast cancer$30,000Funding Body: Hunter Medical Research Institute

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000Funding Body: Trade and Investment NSW

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000Funding Body: NHMRC (National Health & Medical Research Council)

2011 (12 grants)

Chemical principles underpinning a spermostatic-microbiostatic agent capable of preventing pregnancy and the spread of sexually transmitted disease$735,000Funding Body: ARC (Australian Research Council)

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831Funding Body: NHMRC (National Health & Medical Research Council)

Establishment of a comprehensive regional biophysical analysis facility $500,000Funding Body: ARC (Australian Research Council)

Chemical Biology$444,961Funding Body: University of Newcastle

Sulfonadyn-based dynamin I-specific inhibitors and epilepsy$403,931Funding Body: NHMRC (National Health & Medical Research Council)

Establishment of a comprehensive regional biophysical analysis facility $230,000Funding Body: ARC (Australian Research Council)

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$214,000Funding Body: ARC (Australian Research Council)

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$147,500Funding Body: Neoculi Pty Ltd

Dynamin as a new drug target for the treatment of glioblastoma$96,000Funding Body: Cancer Council NSW

Development of clathrin inhibitors as novel endocytosis inhibitors$25,000Funding Body: University of Newcastle

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000Funding Body: NHMRC (National Health & Medical Research Council)

Restocking the Cupboard - Next generation Antibiotics$9,758Funding Body: University of Newcastle

2010 (9 grants)

Australian Cancer Research Foundation Cancer Research Grant$1,012,636Funding Body: Australian Cancer Research Foundation

Development of a humane non-surgical sterilization method for domestic animals$1,006,825Funding Body: Found Animals Foundation Inc

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000Funding Body: ARC (Australian Research Council)

Streamlining the dynamin epilepsy drug pipeline$438,000Funding Body: ARC (Australian Research Council)

The 2009 Ramaciotti Major Initiative Biomedical Research Award$300,000Funding Body: Ramaciotti Foundations

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000Funding Body: University of Newcastle

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000Funding Body: NHMRC (National Health & Medical Research Council)

Centre for Kinomics$25,000Funding Body: John Morris Scientific Pty Ltd

The design of novel, affinity-based technology to specifically isolate phosphotyrosine-containing pedtides$25,000Funding Body: Hunter Children`s Research Foundation

2009 (6 grants)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000Funding Body: ARC (Australian Research Council)

Development of dynamin inhibitors as novel therapies for epilepsy$306,001Funding Body: NHMRC (National Health & Medical Research Council)

Preclinical new chemical entities as novel anti-epileptic drugs targeting dynamin$132,924Funding Body: Epilepsy Foundation of America

Dynamin as a new drug target for he treatment of glioblastoma$74,457Funding Body: James S. McDonnell Foundation

Development of novel anti-epileptic drugs targeting vesicular endocytosis$66,200Funding Body: NHMRC (National Health & Medical Research Council)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000Funding Body: ARC (Australian Research Council)

2008 (5 grants)

HMRI Cancer Research Program - MRSP Infrastructure$1,031,290Funding Body: Hunter Medical Research Institute

Integrated surface fabrication and characterisation laboratory$750,000Funding Body: ARC (Australian Research Council)

The discovery and validation of novel drug classes against parasites of major economic importance$670,000Funding Body: ARC (Australian Research Council)

Partner contributions for Integrated surface fabrication and characterisation laboratory$320,000Funding Body: ARC (Australian Research Council)

The discovery and validation of novel drug classes against parasites of major economic importance$270,000Funding Body: Genetic Technologies Limited

2007 (4 grants)

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$378,942Funding Body: ARC (Australian Research Council)

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000Funding Body: Entech Industries

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$105,000Funding Body: Australian Federal Police

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000Funding Body: Entech Industries Pty Ltd

2006 (4 grants)

PRC - Priority Research Centre for Organic Electronics & OrganoBiosensors$549,282Funding Body: University of Newcastle

Consequences of Dynamin 2 PH Domain Dysfunction in Charcot-Marie-Tooth Neuropathy$217,500Funding Body: NHMRC (National Health & Medical Research Council)

Chemical Interventions in Neurological Diseases?$20,000Funding Body: University of Newcastle

BIT's 4th Annual Congress of International Drug Discovery Science & Technology 25 May - 2 June 2006$2,400Funding Body: University of Newcastle

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$180,000
Funding Body: ARC (Australian Research Council)

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$175,000
Funding Body: University of Newcastle

Multi-Centre Screening and Development Platform for Pre-Clinical Drugs for Glioblastoma$101,612
Funding Body: Cancer Council NSW

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: Hunter Medical Research Institute

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: University of Newcastle

Mechanism Of Action Of Dynamin Ring Stabilizer Compounds Controlling The Actin Cytoskeleton $318,510
Funding Body: NHMRC (National Health & Medical Research Council)

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$245,100
Funding Body: NHMRC (National Health & Medical Research Council)

Bioaffinity mass spectrometry infrastructure to identify small molecules binding to therapeutic targets$125,000
Funding Body: University of Newcastle

Identification of a novel target for the treatment of hormone positive breast cancer$30,000
Funding Body: Hunter Medical Research Institute

The role of clathrin in the spindle assembly checkpoint and as an anticancer target$15,000
Funding Body: Trade and Investment NSW

Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Chemical principles underpinning a spermostatic-microbiostatic agent capable of preventing pregnancy and the spread of sexually transmitted disease$735,000
Funding Body: ARC (Australian Research Council)

Development of pthaladyn-based dynamin I-selective inhibitors for treatment of epilepsy$544,831
Funding Body: NHMRC (National Health & Medical Research Council)

Establishment of a comprehensive regional biophysical analysis facility $500,000
Funding Body: ARC (Australian Research Council)

Chemical Biology$444,961
Funding Body: University of Newcastle

Sulfonadyn-based dynamin I-specific inhibitors and epilepsy$403,931
Funding Body: NHMRC (National Health & Medical Research Council)

Establishment of a comprehensive regional biophysical analysis facility $230,000
Funding Body: ARC (Australian Research Council)

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$214,000
Funding Body: ARC (Australian Research Council)

Characterisation of a new class of antimicrobial agent for multidrug-resistant infections$147,500
Funding Body: Neoculi Pty Ltd

Dynamin as a new drug target for the treatment of glioblastoma$96,000
Funding Body: Cancer Council NSW

Development of clathrin inhibitors as novel endocytosis inhibitors$25,000
Funding Body: University of Newcastle

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)

Restocking the Cupboard - Next generation Antibiotics$9,758
Funding Body: University of Newcastle

Australian Cancer Research Foundation Cancer Research Grant$1,012,636
Funding Body: Australian Cancer Research Foundation

Development of a humane non-surgical sterilization method for domestic animals$1,006,825
Funding Body: Found Animals Foundation Inc

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000
Funding Body: ARC (Australian Research Council)

Streamlining the dynamin epilepsy drug pipeline$438,000
Funding Body: ARC (Australian Research Council)

The 2009 Ramaciotti Major Initiative Biomedical Research Award$300,000
Funding Body: Ramaciotti Foundations

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000
Funding Body: University of Newcastle

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Centre for Kinomics$25,000
Funding Body: John Morris Scientific Pty Ltd

The design of novel, affinity-based technology to specifically isolate phosphotyrosine-containing pedtides$25,000
Funding Body: Hunter Children`s Research Foundation

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

Development of dynamin inhibitors as novel therapies for epilepsy$306,001
Funding Body: NHMRC (National Health & Medical Research Council)

Preclinical new chemical entities as novel anti-epileptic drugs targeting dynamin$132,924
Funding Body: Epilepsy Foundation of America

Dynamin as a new drug target for he treatment of glioblastoma$74,457
Funding Body: James S. McDonnell Foundation

Development of novel anti-epileptic drugs targeting vesicular endocytosis$66,200
Funding Body: NHMRC (National Health & Medical Research Council)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

HMRI Cancer Research Program - MRSP Infrastructure$1,031,290
Funding Body: Hunter Medical Research Institute

Integrated surface fabrication and characterisation laboratory$750,000
Funding Body: ARC (Australian Research Council)

The discovery and validation of novel drug classes against parasites of major economic importance$670,000
Funding Body: ARC (Australian Research Council)

Partner contributions for Integrated surface fabrication and characterisation laboratory$320,000
Funding Body: ARC (Australian Research Council)

The discovery and validation of novel drug classes against parasites of major economic importance$270,000
Funding Body: Genetic Technologies Limited

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$378,942
Funding Body: ARC (Australian Research Council)

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000
Funding Body: Entech Industries

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$105,000
Funding Body: Australian Federal Police

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000
Funding Body: Entech Industries Pty Ltd

PRC - Priority Research Centre for Organic Electronics & OrganoBiosensors$549,282
Funding Body: University of Newcastle

Consequences of Dynamin 2 PH Domain Dysfunction in Charcot-Marie-Tooth Neuropathy$217,500
Funding Body: NHMRC (National Health & Medical Research Council)

Chemical Interventions in Neurological Diseases?$20,000
Funding Body: University of Newcastle

BIT's 4th Annual Congress of International Drug Discovery Science & Technology 25 May - 2 June 2006$2,400
Funding Body: University of Newcastle

High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)

Selective detection and removal of contaminants that have an adverse impact on Australian raw sugar quality$190,000
Funding Body: ARC (Australian Research Council)

Biacore3000-Expansion of Proteomics Facility$187,341
Funding Body: ARC (Australian Research Council)

In-field sensors for the detection of illicit drugs$171,336
Funding Body: ARC (Australian Research Council)

Selective detection and removal of contaminants that have adverse impact on Australian raw sugar quality$51,000
Funding Body: Bureau of Sugar Experiment Stations

In-field sensors for the detection of illicit drugs$45,000
Funding Body: Australian Federal Police

Improving Drug Development: New Approaches to Rapid Development of Novel Lead Compounds$27,542
Funding Body: Ramaciotti Foundations

New drugs targeting protein kinases$17,000
Funding Body: Hunter Medical Research Institute

Radiocarbon dating of heroin samples as a tool to verify the conversion to alternative crops.$5,820
Funding Body: AINSE (Australian Institute of Nuclear Science & Engineering)

Implementation of a Methamphetamine Method for the Australian Federal Police$230,309
Funding Body: Australian Federal Police

Dynamin inhibitors as tools for dissecting the endocytic pathways neurons$165,000
Funding Body: NHMRC (National Health & Medical Research Council)

High Pressure and Fluorous Approaches to fostriecin libraries: New Therapeutic Opportunities.$50,000
Funding Body: ARC (Australian Research Council)

Implementation of a Methamphetamine Method for the Australian Federal Police$30,000
Funding Body: Australian Federal Police

Antagonist of Corticotrophin Releasing Hormone as Therapeutic Agents for the Prevention of Premature Birth in Humans$375,000
Funding Body: NHMRC (National Health & Medical Research Council)

Devevelopement and Use of Ionic Liquids in Metal Recovery from Ores, Concentrates and Mattes.$205,000
Funding Body: ARC (Australian Research Council)

New targets for chemotherapy: anti-cancer drugs that target protein phosphatases$10,000
Funding Body: University of Newcastle

Development of new therapeutic agents for the treatment of epilepsy$8,000
Funding Body: University of Newcastle

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology.$30,268
Funding Body: Grape & Wine Research and Development Corporation

Development of new drugs for the prevention of premature birth$10,000
Funding Body: University of Newcastle

Environmentally friendly ('Green') organic chemistry: Development of novel methodologies and reagents.$5,000
Funding Body: University of Newcastle

92nd American Association for Cancer Research Annual Meeting, USA 24-28 March 2001$2,400
Funding Body: University of Newcastle

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology.$26,950
Funding Body: Grape & Wine Research and Development Corporation

Synthesis of Drugs for Prevention of Pre-Term Delivery.$10,000
Funding Body: University of Newcastle

Towards Green Chemistry: The Development of Environmentally Organic Synthesis.$7,000
Funding Body: University of Newcastle

Selective Inhibitors of Protein Phosphatases as Anti-cancer agents$25,000
Funding Body: Hunter Medical Research Institute

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology$20,000
Funding Body: Grape & Wine Research and Development Corporation

Rapid Microscale Synthesis of Drugs for the Prevention of Pre-Term Delivery$13,500
Funding Body: University of Newcastle

Development of a Versatile, Sensitive, Non-Isotopoic Method for Detecting Phosphorylated and Glycosylated Serines in Proteins and Peptides$10,000
Funding Body: University of Newcastle