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Career Summary

Biography

Dr Pradeep Tanwar is an ARC Future Fellow, a lecturer at the University of Newcastle, a member of the Cancer Biology Program of the Hunter Medical Research Institute and an investigator of the Hunter Cancer Research Alliance.  Throughout his research career, Dr Tanwar’s research work has focussed on defining molecular footsteps involved in the pathogenesis of the reproductive tract cancers. In the last 5 years, Dr Tanwar’s work resulted in 15 research publications in high impact journals including PNAS x2, Cancer Research, Human Molecular Genetics, PLos Genetics, Nature Genetics and Carcinogenesis x3, and led to invitations to speak at various conferences/symposiums such as Gordon Conference on Reproductive Tract Biology and Reproductive and Endocrine-related Cancer Symposium jointly organised by the Society of Reproductive Biology and the Endocrine Society of Australia.  His group is using genetically modified mouse models, cancer patient-derived xenograft models and primary human tissue samples to define the molecular and cellular events involved in carcinogenesis and then using this knowledge to develop targeted therapies to improve clinical outcomes in human patients.

Research

Research keywords

  • Developmental biology
  • Genitourinary cancers
  • Gynecologic oncology

Research expertise

1. Role of Microenvironment in Endometrial cancer

2. Wnt-PI3K-mTOR signaling axis, EMT (Epithelial Mesenchymal Transition), and ovarian cancer

3. Cancer stem cells in ovarian cancer

3. Pathogenesis of Genitourinary cancers (Tesicular and Prostate cancer)

Languages

  • English

Fields of Research

CodeDescriptionPercentage
111201Cancer Cell Biology50
111203Cancer Genetics30
060403Developmental Genetics (Incl. Sex Determination)20

Collaboration

Professor Patricia Donahoe, Harvard Medical School, USA

Associate Professor Jose Teixeira, Michigan State University, USA

Teaching

Teaching keywords

  • Cancer biology
  • Developmental biology
  • Genetics

Teaching expertise

Course coordinator for HUBS2107: Mammalian Growth and Development

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (18 outputs)

YearCitationAltmetricsLink
2014Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, et al., 'Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer', CARCINOGENESIS, 35 546-553 (2014)
2014Tanwar PS, Kaneko-Tarui T, Teixeira JM, 'Constitutive Wnt/B-Catenin Signaling in Mice in the Absence of Mullerian Inhibiting Substance/AntiMulleiran Hormone Signaling Leads to the Development of a Polycystic Ovary Phenotype', REPRODUCTIVE SCIENCES, 21 125A-126A (2014)
2013Kaneko-Tarui T, Lee H, Zhang L, Teixeira JM, Tanwar PS, 'PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression', Carcinogenesis, 34 893-901 (2013) [C1]
2012Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM, 'Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of sertoli cell polarity and spermatogenesis', Human Molecular Genetics, 21 4394-4405 (2012) [C1]
2012Meirelles K, Benedict LA, Dombkowski D, Pepin D, Preffer FI, Teixeira J, et al., 'Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109 2358-2363 (2012) [C1]
2012Tanwar PS, Commandeur AE, Zhang L, Taketo MM, Teixeira JM, 'The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained beta-catenin signaling', CARCINOGENESIS, 33 2351-2361 (2012) [C1]
2012Tanwar PS, Kaneko-Tarui T, Zhang L, Tanaka Y, Crum CP, Teixeira JM, 'Stromal liver kinase B1 STK11 signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian target of Rapamycin Complex 1', PLOS Genetics, 8 1-14 (2012) [C1]
2012Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Lee H-J, Teixeira JM, 'Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility', ENDOCRINOLOGY, 153 404-416 (2012) [C1]
2011Tanwar PS, Zhang L, Roberts DJ, Teixeira JM, 'Stromal Deletion of the APC Tumor Suppressor in Mice Triggers Development of Endometrial Cancer', CANCER RESEARCH, 71 1584-1596 (2011) [C1]
2011Tanwar PS, McFarlane JR, 'Dynamic expression of bone morphogenetic protein 4 in reproductive organs of female mice', REPRODUCTION, 142 573-579 (2011) [C1]
2011Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, et al., 'Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/beta-Catenin and PTEN', PLOS ONE, 6 (2011) [C1]
2011Tanwar PS, Zhang L, Teixeira JM, 'Adenomatous Polyposis Coli (APC) Is Essential for Maintaining the Integrity of the Seminiferous Epithelium', MOLECULAR ENDOCRINOLOGY, 25 1725-1739 (2011) [C1]
2010Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira JM, 'Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 16142-16147 (2010) [C1]
2010Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J, 'Constitutive WNT/Beta-Catenin Signaling in Murine Sertoli Cells Disrupts Their Differentiation and Ability to Support Spermatogenesis', BIOLOGY OF REPRODUCTION, 82 422-432 (2010) [C1]
2009Tanwar PS, Lee H-J, Zhang L, Zukerberg LR, Taketo MM, Rueda BR, Teixeira JM, 'Constitutive Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of Mesenchymal Tumors in Mice', BIOLOGY OF REPRODUCTION, 81 545-552 (2009) [C1]
2009Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, et al., 'Lin28 promotes transformation and is associated with advanced human malignancies', NATURE GENETICS, 41 843-U109 (2009) [C1]
2008Wu X, Tanwar PS, Raftery LA, 'Drosophila follicle cells: Morphogenesis in an eggshell', SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 19 271-282 (2008) [C1]
2008Wu X, Yamada-Mabuchi M, Morris EJ, Tanwar PS, Dobens L, Gluderer S, et al., 'The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 5414-5419 (2008) [C1]
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Conference (7 outputs)

YearCitationAltmetricsLink
2013Tanwar PS, 'Frequent alterations in mTOR signaling in human ovarian serous carcinomas', 25th Lorne Cancer Conference, Lorne, Victoria, Australia (2013) [E3]
2013Tanwar PS, 'Preclinical models of ovarian cancer: PI3K-mTOR signalling axis', Translational Cancer Research Conference, Newcastle, NSW, Australia (2013) [E3]
2013Tanwar PS, 'The Müllerian Inhibiting Substance type 2 receptor is an endogenous tumor suppressor and its loss phenocopies PTEN loss or activation of Kras in testes with sustained ßcatenin signaling', Society of Reproductive Biology Endocrine Society of Australia Annual Scientific Meeting, Sydney, NSW, Australia (2013) [E3]
2011Tanwar PS, Zhang L, Teixeira J, 'APC (Adenomatous Polyposis Coli), a Tumor Suppressor Gene, Is Required for Maintenance of Sertoli Cell Polarity and Microtubules Integrity.', BIOLOGY OF REPRODUCTION, Portland, OR (2011) [E3]
2010Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Teixeira J, 'DELETION OF TSC1 IN OVARIAN SOMATIC CELLS OF THE FEMALE REPRODUCTIVE TRACT CAUSES INFERTILITY.', FERTILITY AND STERILITY, Denver, CO (2010) [E3]
2010Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira J, 'Mullerian Mesenchyme-Specific Activation of Wnt/Beta-Catenin Signaling Inhibits Mullerian Duct Regression and Contributes to Male Infertility', BIOLOGY OF REPRODUCTION, Milwaukee, WI (2010) [E3]
2009Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J, 'Progressive Spermatogonial Stem Cell Loss in Mice with Constitutively Activated Beta-Catenin in Postpubertal Sertoli Cells is Associated with Persistent Expression or GDNF and MIS.', BIOLOGY OF REPRODUCTION, Pittsburgh, PA (2009) [E3]
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Grants and Funding

Summary

Number of grants8
Total funding$1,198,210

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (2 grants)

DVC(R) Research Support for Future Fellow (FT13)$60,000
Funding Body: University of Newcastle

Project Team
Doctor Pradeep Tanwar
SchemeRole
Special Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$60,00020142017
GNo:G1301419

Transforming Women's Health via Translational Investigation, Florence Italy, 26-29 March 2014$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Pradeep Tanwar
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020142014
GNo:G1400204

2013 (5 grants)

mTOR signalling in serous ovarian cancer$749,814
Funding Body: ARC (Australian Research Council)

Project Team
Doctor Pradeep Tanwar
SchemeRole
Future FellowshipsChief Investigator
Total AmountFunding StartFunding Finish
$749,81420132017
GNo:G1300140

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

High Resolution Triple Fluorescence Stereomicroscope$30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Pradeep Tanwar
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020132013
GNo:G1301311

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Conjoint Associate Professor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Doctor Gabrielle Briggs, Emeritus Professor Leonie Ashman, Emeritus Professor John Rostas
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$24,59620132013
GNo:G1201189

Role of Wnt-P13K-mTOR signalling reproductive functions and gynecology/genitourinary cancers$5,000
Funding Body: University of Newcastle

Project Team
Doctor Pradeep Tanwar
SchemeRole
New Staff GrantChief Investigator
Total AmountFunding StartFunding Finish
$5,00020132013
GNo:G1300983

2012 (1 grants)

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW

Project Team
Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Emeritus Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar
SchemeRole
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$292,30020122014
GNo:G1200798
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Research Supervision

Number of current supervisions5
Total current UoN PhD EFTSL4.5

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Medical Biochemistry)Principal SupervisorInvestigating Genetic Alteration in Pathogenesis of Urine Endometrial Cancers
20142018PhD (Medical Biochemistry)Principal SupervisorTo Investigate the Interaction of Bone Marrow Derived Endothelial Progenitor Cells (EPCs) with Ovarian Cancer Stem Cells (CSCs) in Tumor Angiogenesis Invasion
20132017PhD (Medical Biochemistry)Principal SupervisorIdentification and Targeting of Novel Biomarkers of Ovarian Cancer Stem Cells
20132017PhD (Medical Biochemistry)Principal SupervisorStudies on Effect of P13K Inhibitors on P13K/Akt Signaling Pathway in Akt Mutant and Wild Type Murine Models to Control Endometrial Cancer
20132017PhD (Medical Biochemistry)Principal SupervisorRole of Stromal WNT Signaling in Ovarian Epithelial Carcinogenesis
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Dr Pradeep Tanwar

Work Phone(02) 4921 5148
Email
PositionARC Future Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Office
LS3-48,
Life Sciences Building: 348,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/pradeep-tanwar