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Dr Pradeep Tanwar

ARC Future Fellow

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Dr Pradeep Tanwar is an ARC Future Fellow, a Cancer Institute NSW Career Development Fellow and an investigator of the Hunter Cancer Research Alliance.  Throughout his research career, Dr Tanwar’s research work has focussed on defining molecular footsteps involved in the pathogenesis of the reproductive tract cancers. In the last 5 years, Dr Tanwar’s work resulted in 15 research publications in high impact journals including PNAS x2, Cancer Research, Human Molecular Genetics, PLos Genetics, Nature Genetics and Carcinogenesis x3, and led to invitations to speak at various conferences/symposiums such as Gordon Conference on Reproductive Tract Biology and Reproductive and Endocrine-related Cancer Symposium jointly organised by the Society of Reproductive Biology and the Endocrine Society of Australia.  His group is using genetically modified mouse models, cancer patient-derived xenograft models and primary human tissue samples to define the molecular and cellular events involved in carcinogenesis and then using this knowledge to develop targeted therapies to improve clinical outcomes in human patients.

Research Expertise
1. Role of Microenvironment in Endometrial cancer 2. Wnt-PI3K-mTOR signaling axis, EMT (Epithelial Mesenchymal Transition), and ovarian cancer 3. Cancer stem cells in ovarian cancer 3. Pathogenesis of Genitourinary cancers

Teaching Expertise
Course coordinator for HUBS2107: Mammalian Growth and Development

Collaborations
Professor Patricia Donahoe, Harvard Medical School, USA Professor Jose Teixeira, Michigan State University, USA

Keywords

  • Cancer biology
  • Cancer stem cells
  • Endometrial cancer
  • Genetics
  • Genitourinary cancers
  • Gynecologic oncology
  • PCOS
  • ovarian cancer

Languages

  • English (Fluent)

Fields of Research

Code Description Percentage
060403 Developmental Genetics (incl. Sex Determination) 20
111201 Cancer Cell Biology 50
111203 Cancer Genetics 30

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/08/2012 - 13/12/2014 Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (17 outputs)

Year Citation Altmetrics Link
2014 Tanwar PS, Mohapatra G, Chiang S, Engler DA, Zhang L, Kaneko-Tarui T, et al., 'Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer', CARCINOGENESIS, 35 546-553 (2014) [C1]
DOI 10.1093/carcin/bgt357
Citations Scopus - 7Web of Science - 4
2013 Tanwar PS, Kaneko-Tarui T, Lee H, Zhang L, Teixeira JM, 'PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression', Carcinogenesis, 34 893-901 (2013) [C1]

Epithelial ovarian cancer is a heterogeneous disease that is subdivided into five major histotypes but the mechanisms driving their differentiation are not clear. Mutations in ade... [more]

Epithelial ovarian cancer is a heterogeneous disease that is subdivided into five major histotypes but the mechanisms driving their differentiation are not clear. Mutations in adenomatous polyposis coli (APC) and ß-catenin are commonly observed in the human ovarian endometrioid adenocarcinoma (OEA) patients. However, the mechanisms subsequent to APC deletion in ovarian tumorigenesis have not been well characterized. We have conditionally deleted APC in the murine ovarian surface epithelium (OSE) and showed that its loss leads to development of epithelial inclusion cysts. High-grade OEAs with tightly packed villoglandular histology were observed in older APC-deleted mice. Phosphatase and tensin homolog (PTEN) expression was elevated in the early lesions but lost after progression to the more advanced tumors. Knockdown of APC or expression of a gain-of-function ß-catenin similarly induced human OSE cells to develop tumors with endometrioid histology in xenografts. Expression of HOXA10 was induced in both the advanced APC-deleted murine tumors and in the tumor xenografts of human OSE cells with knocked-down APC. These results show that reduced APC activity is sufficient to induce formation of epithelial inclusion cysts and support OEA development and suggest that induced HOXA10 expression and loss of PTEN are key mechanisms driving endometrioid histotype differentiation and progression. © The Author 2012.Published by Oxford University Press. All rights reserved.

DOI 10.1093/carcin/bgs405
Citations Scopus - 7Web of Science - 5
2012 Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Lee H-J, Teixeira JM, 'Deletion of Tuberous Sclerosis 1 in Somatic Cells of the Murine Reproductive Tract Causes Female Infertility', ENDOCRINOLOGY, 153 404-416 (2012) [C1]
DOI 10.1210/en.2011-1191
Citations Scopus - 12Web of Science - 11
2012 Meirelles K, Benedict LA, Dombkowski D, Pepin D, Preffer FI, Teixeira J, et al., 'Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109 2358-2363 (2012) [C1]
DOI 10.1073/pnas.1120733109
Citations Scopus - 35Web of Science - 27
2012 Tanwar PS, Commandeur AE, Zhang L, Taketo MM, Teixeira JM, 'The Mullerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained beta-catenin signaling', CARCINOGENESIS, 33 2351-2361 (2012) [C1]
DOI 10.1093/carcin/bgs281
Citations Scopus - 2Web of Science - 2
2012 Tanwar PS, Kaneko-Tarui T, Zhang L, Teixeira JM, 'Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of sertoli cell polarity and spermatogenesis', Human Molecular Genetics, 21 4394-4405 (2012) [C1]
Citations Scopus - 16Web of Science - 15
2012 Tanwar PS, Kaneko-Tarui T, Zhang L, Tanaka Y, Crum CP, Teixeira JM, 'Stromal liver kinase B1 STK11 signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian target of Rapamycin Complex 1', PLOS Genetics, 8 1-14 (2012) [C1]
Citations Scopus - 12Web of Science - 10
2011 Tanwar PS, Zhang L, Kaneko-Tarui T, Curley MD, Taketo MM, Rani P, et al., 'Mammalian Target of Rapamycin Is a Therapeutic Target for Murine Ovarian Endometrioid Adenocarcinomas with Dysregulated Wnt/beta-Catenin and PTEN', PLOS ONE, 6 (2011) [C1]
DOI 10.1371/journal.pone.0020715
Citations Scopus - 17Web of Science - 18
2011 Tanwar PS, Zhang L, Roberts DJ, Teixeira JM, 'Stromal Deletion of the APC Tumor Suppressor in Mice Triggers Development of Endometrial Cancer', CANCER RESEARCH, 71 1584-1596 (2011) [C1]
DOI 10.1158/0008-5472.CAN-10-3166
Citations Scopus - 25Web of Science - 21
2011 Tanwar PS, Zhang L, Teixeira JM, 'Adenomatous Polyposis Coli (APC) Is Essential for Maintaining the Integrity of the Seminiferous Epithelium', MOLECULAR ENDOCRINOLOGY, 25 1725-1739 (2011) [C1]
DOI 10.1210/me.2011-0057
Citations Scopus - 12Web of Science - 12
2011 Tanwar PS, McFarlane JR, 'Dynamic expression of bone morphogenetic protein 4 in reproductive organs of female mice', REPRODUCTION, 142 573-579 (2011) [C1]
DOI 10.1530/REP-10-0299
Citations Scopus - 9Web of Science - 9
2010 Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J, 'Constitutive WNT/Beta-Catenin Signaling in Murine Sertoli Cells Disrupts Their Differentiation and Ability to Support Spermatogenesis', BIOLOGY OF REPRODUCTION, 82 422-432 (2010) [C1]
DOI 10.1095/biolreprod.109.079335
Citations Scopus - 45Web of Science - 43
2010 Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira JM, 'Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107 16142-16147 (2010) [C1]
DOI 10.1073/pnas.1011606107
Citations Scopus - 10Web of Science - 10
2009 Tanwar PS, Lee H-J, Zhang L, Zukerberg LR, Taketo MM, Rueda BR, Teixeira JM, 'Constitutive Activation of Beta-Catenin in Uterine Stroma and Smooth Muscle Leads to the Development of Mesenchymal Tumors in Mice', BIOLOGY OF REPRODUCTION, 81 545-552 (2009) [C1]
DOI 10.1095/biolreprod.108.075648
Citations Scopus - 41Web of Science - 39
2009 Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng TL, Toffanin S, et al., 'Lin28 promotes transformation and is associated with advanced human malignancies', NATURE GENETICS, 41 843-U109 (2009) [C1]
DOI 10.1038/ng.392
Citations Scopus - 332Web of Science - 309
2008 Wu X, Tanwar PS, Raftery LA, 'Drosophila follicle cells: Morphogenesis in an eggshell', SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 19 271-282 (2008) [C1]
DOI 10.1016/j.semcdb.2008.01.004
Citations Scopus - 48Web of Science - 48
2008 Wu X, Yamada-Mabuchi M, Morris EJ, Tanwar PS, Dobens L, Gluderer S, et al., 'The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105 5414-5419 (2008) [C1]
DOI 10.1073/pnas.0800945105
Citations Scopus - 13Web of Science - 11
Show 14 more journal articles

Conference (9 outputs)

Year Citation Altmetrics Link
2014 Kumar M, Sahoo SS, Tanwar P, 'MTOR: A NOVEL TARGET FOR TESTICULAR CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Newcastle, NSW (2014) [E3]
2014 Tanwar PS, Kaneko-Tarui T, Teixeira JM, 'Constitutive Wnt/B-Catenin Signaling in Mice in the Absence of Mullerian Inhibiting Substance/AntiMulleiran Hormone Signaling Leads to the Development of a Polycystic Ovary Phenotype', REPRODUCTIVE SCIENCES (2014) [E3]
2013 Tanwar PS, 'Frequent alterations in mTOR signaling in human ovarian serous carcinomas', 25th Lorne Cancer Conference, Lorne, Victoria, Australia (2013) [E3]
2013 Tanwar PS, 'The Müllerian Inhibiting Substance type 2 receptor is an endogenous tumor suppressor and its loss phenocopies PTEN loss or activation of Kras in testes with sustained ßcatenin signaling', Society of Reproductive Biology Endocrine Society of Australia Annual Scientific Meeting, Sydney, NSW, Australia (2013) [E3]
2013 Tanwar PS, 'Preclinical models of ovarian cancer: PI3K-mTOR signalling axis', Translational Cancer Research Conference, Newcastle, NSW, Australia (2013) [E3]
2011 Tanwar PS, Zhang L, Teixeira J, 'APC (Adenomatous Polyposis Coli), a Tumor Suppressor Gene, Is Required for Maintenance of Sertoli Cell Polarity and Microtubules Integrity.', BIOLOGY OF REPRODUCTION, Portland, OR (2011) [E3]
2010 Tanwar PS, Zhang L, Tanaka Y, Taketo MM, Donahoe PK, Teixeira J, 'Mullerian Mesenchyme-Specific Activation of Wnt/Beta-Catenin Signaling Inhibits Mullerian Duct Regression and Contributes to Male Infertility', BIOLOGY OF REPRODUCTION, Milwaukee, WI (2010) [E3]
2010 Tanaka Y, Park JH, Tanwar PS, Kaneko-Tarui T, Mittal S, Teixeira J, 'DELETION OF TSC1 IN OVARIAN SOMATIC CELLS OF THE FEMALE REPRODUCTIVE TRACT CAUSES INFERTILITY.', FERTILITY AND STERILITY, Denver, CO (2010) [E3]
2009 Tanwar PS, Kaneko-Tarui T, Zhang L, Rani P, Taketo MM, Teixeira J, 'Progressive Spermatogonial Stem Cell Loss in Mice with Constitutively Activated Beta-Catenin in Postpubertal Sertoli Cells is Associated with Persistent Expression or GDNF and MIS.', BIOLOGY OF REPRODUCTION, Pittsburgh, PA (2009) [E3]
Show 6 more conferences
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Grants and Funding

Summary

Number of grants 17
Total funding $3,017,517

Click on a grant title below to expand the full details for that specific grant.


20158 grants / $1,747,633

Targeting chemoresistant ovarian cancer cells$508,396

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Doctor Pradeep Tanwar
Scheme Career Development Fellowship
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1400754
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

High resolution fourier transform mass spectrometry platform for the discovery of novel cancer biomarkers and drug targets using label-free and isobaric-tagged approaches for quantitative proteomics.$500,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Professor Xu Dong Zhang, Doctor Matt Dun, Professor Jennifer Martin, Professor Hubert Hondermarck, Laureate Professor John Aitken, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Professor Rodney Scott, Professor Maria Kavallaris, Dr Darren Saunders
Scheme Research Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo G1500599
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Contribution of ovarian cancer stem cells to chemoresistance and recurrent disease.$367,077

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Pradeep Tanwar
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1400046
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

High resolution fourier transform mass spectrometry platform for the discovery of novel cancer biomarkers and drug targets using label-free and isobaric-tagged approaches for quantitative proteomics.$196,250

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Xu Dong Zhang, Doctor Matt Dun, Professor Jennifer Martin, Professor Hubert Hondermarck, Laureate Professor John Aitken, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Professor Rodney Scott, Professor Maria Kavallaris, Dr Darren Saunders
Scheme Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500935
Type Of Funding Internal
Category INTE
UON Y

Live cell imager for enhancement of pre-clinical cancer studies in the Hunter Translational Cancer Research Centre$124,938

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Conjoint Professor Stephen Ackland, Doctor Kelly Kiejda, Associate Professor Kevin Spring, Professor Xu Dong Zhang, Associate Professor Deborah Marsh, Doctor Christopher Scarlett, Doctor Pradeep Tanwar, Doctor Kathryn Skelding, Doctor Rick Thorne, Doctor Nikola Bowden
Scheme Research Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo G1500598
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Uterine fibroids: Molecular basis of pathogenesis of uterine leiomyoma$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Pradeep Tanwar, Doctor Pravin Nahar
Scheme Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500010
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Live cell imager for enhancement of pre-clinical cancer studies in the Hunter Translational Cancer Research Centre$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Stephen Ackland, Doctor Kelly Kiejda, Associate Professor Kevin Spring, Professor Xu Dong Zhang, Associate Professor Deborah Marsh, Doctor Christopher Scarlett, Doctor Pradeep Tanwar, Doctor Kathryn Skelding, Doctor Rick Thorne, Doctor Nikola Bowden
Scheme Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500953
Type Of Funding Internal
Category INTE
UON Y

The Annual Scientific Meeting of the Endocrine Society of Australia and the Society of Reproductive Biology, Adelaide Australia, 23-26 August 2015$750

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Pradeep Tanwar
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501056
Type Of Funding Internal
Category INTE
UON Y

20143 grants / $133,174

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

DVC(R) Research Support for Future Fellow (FT13)$60,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Pradeep Tanwar
Scheme Special Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301419
Type Of Funding Internal
Category INTE
UON Y

Transforming Women's Health via Translational Investigation, Florence Italy, 26-29 March 2014$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Pradeep Tanwar
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400204
Type Of Funding Internal
Category INTE
UON Y

20135 grants / $844,410

mTOR signalling in serous ovarian cancer$749,814

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Doctor Pradeep Tanwar
Scheme Future Fellowships
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300140
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

High Resolution Triple Fluorescence Stereomicroscope$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Pradeep Tanwar
Scheme Equipment Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1301311
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Role of Wnt-P13K-mTOR signalling reproductive functions and gynecology/genitourinary cancers$5,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Pradeep Tanwar
Scheme New Staff Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300983
Type Of Funding Internal
Category INTE
UON Y

20121 grants / $292,300

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Research Supervision

Number of supervisions

Completed0
Current9

Total current UON EFTSL

Masters0.9
PhD7

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 Masters Understanding the Development of Ovarian Granulosa Cell Cancer Using a Mouse Model with Mutation in APC Gene in Granulosa Cells
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2015 PhD Investigating Novel Co-molecular Lesions of TP-53 in Serous Adeno Carcinomas and Their Role in DNA Damage
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2015 PhD Biomarkers for Circulating Ovarian Cancer Cells: A Prognostic and Therapeutic Approach
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Role of mTOR signalling in Ovarian Cancer
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Role of microenvironment in endometrial cancer progression, metastasis and drug resistance
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD WNT Signaling in Uterine Cancer
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Role of Wnt Signalling in Testicular Morphogenesis and Carcinogenesis
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Role of Wnt Signalling in Endometrial Homeostasis and Cancer
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Endometrial Stem/Progenitor Cells in Endometrial Regeneration, Carcinogenesis and Aging
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
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News

Dr Pradeep Tanwar

New approach to chemo-resistant ovarian cancer

March 12, 2015

Dr Pradeep Tanwar is working on a protein that has the potential to treat chemotherapy-resistant ovarian cancer.

Dr Mark Lock

$8.8M ARC funding

November 8, 2013

The Australian Research Council (ARC) has today awarded $8.8 million in Discovery Project research funding to the University of Newcastle. The funding will extend across 19 projects, an increase of 6 projects and $4.2 million since last year.

Dr Pradeep Tanwar

Position

ARC Future Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email pradeep.tanwar@newcastle.edu.au
Phone (02) 4921 5148

Office

Room LS2-36
Building Life Sciences Building: 236
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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