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Career Summary

Biography

I am a highly motivated and dedicated medical researcher focused on identifying novel targets and improved therapies for the treatment of the most common and devastating type of leukaemia, acute myeloid leukaemia (AML). I completed my PhD by publication, with distinction and in less than three years, receiving eleven national and international research awards along the way. My PhD was mentored by two of the Universities most respected researchers in Prof John Aitken and Assoc Prof Brett Nixon. The significant contributions made to my field by PhD resulted in my dissertation being awarded the Vice Chancellors Annual Award for Research High Degree Excellence in 2012, and has subsequently laid the foundations to achieve my ambitions of developing a successful and internationally competitive research program here at the University of Newcastle, in collaboration with the Hunter Medical Research Institute (HMRI) and the Hunter Cancer Research Alliance (HCRA).

My current research program in direct collaboration with Dr Nicole Verrills, focuses on the characterisation of new anti-leukaemia drugs synthesised by our collaborators at the UNSW Chemistry Department (Prof Morris) as well as the characterisation of the disease causing mutations that result from somatic and epigenetic mutations seen in acute myeloid leukaemia patients. This work was recently recognised by the Cancer Institute of NSW whom have awarded me an esteemed Early Career Research Fellowship 2014-2016 ('Identifying novel therapeutic targets for the treatment of acute myeloid leukaemia (AML)'). Further, thanks to the fantastic public work performed by the HMRI, I have been fortunate to receive funding from the Hunter Community. Specifically, generous support from Mrs Alyson Gearing enabled me to initiate a ground breaking investigation into the yet unknown disease causing mutations seen in AML. These investigations were conducted in collaboration with the University of Southern Denmark (Prof Larsen) in Odense Denmark in 2013. More recently, the Estate of the Late Mr James Scott Lawrie Project Grants has provided me with the necessary funding to continue my work into the development of a new treatment for AML in 2014.

Currently I am also utilising my recognised skills in experimental biochemistry to investigate the mechanism of action of new drugs synthesised here at the University of Newcastle Chemistry Department (Prof McCluskey) for the treatment of breast cancers. These exciting compounds show remarkable selectivity for breast tumours dependant on estrogen for their growth and survival. These investigations are being conducted in collaboration with Dr Sakoff and Dr Gilbert from the Medical Oncology Laboratory at the Calvary Mater Hospital Newcastle, Dr DeIuliis from the HMRI-HCRA, Prof McCluskey from the University of Newcastle Chemistry Department and the Clinical Oncologist Prof Ackland also from the Calvary Mater Hospital Newcastle.

Qualifications

  • PhD (Biological Science), University of Newcastle, 28/02/2012
  • Bachelor of Biotechnology (Honours), University of Newcastle, 12/12/2008
  • Bachelor of Biotechnology, University of Newcastle, 10/12/2007

Research

Research keywords

  • Anti-Cancer Drug Targeting
  • Biochemistry
  • Cancer
  • Chemical Proteomics
  • Leukaemia
  • Phosphoproteomics
  • Proteomics

Research expertise

Since the complete of my PhD I commenced my postdoctoral training within the Faculty of Health and Medicine Cancer Priority Research Centre at the Hunter Medical Research Institute (HMRI), associated with the Hunter Cancer Research Alliance (HCRA) and in collaboration with the Calvary Mater Hospital Medical Oncology Department. My Research Program is focused on elucidating the biochemical mechanisms that underpin novel anti-cancer therapies for improved treatment regimens for acute myeloid leukaemia (AML) and breast cancer. In this context, my technical strengths in many aspects of cell analysis, including: characterisation of protein expression, proteomic profiling including iTRAQ and SILAC, phosphoproteomics, DNA mutational analysis, cellular imagery, identification of protein-protein interactions via immunoprecipitation, Far-Western blotting and Blue Native PAGE, cell culture, functional assays and the generation of recombinant proteins and polyclonal antibodies has been recognised. My ever growing knowledge and skill base has benefited from close association with national and international colleagues.

Funding from the HMRI in 2013 enabled me to spend a month working at Institut for Biokemi og Molekylær Biologi at the Syddansk Universitet where I worked with experts in proteomic assays, including phosphoproteomics, membrane proteomics, glycoproteomics, iTRAQ and SILIC. These phosphoproteomics studies utilised Hunter AML patients samples and is allowing us to determine the effect of oncogenic signalling to help determine novel treatment targets and identify the disease causing mutations associated with recurrent DNA mutations seen in AML. These complex investigations are aimed at unravelling the pathogenesis of disease, with the resulting data providing us with a better understanding of each condition. Following this sabbatical I was fortunate to present my work on AML at the American Association of Cancer Research in Washington DC.

In 2013 I received the Australian Society for Medical Research Recipient of the NSW Office for Health and Medical Research Postdoctoral Award for Excellence in Medical Research. This award was presented at the ASMR NSW Scientific Meeting.

Commencing 2014 my research program is strongly supported thanks to the Cancer Institute of NSW Early Career Research Fellowship. This funding is for three years and aims to 'Identify novel therapeutic targets for the treatment of Acute Myeloid Leukaemia'.

These experiences are helping me to establishing a firm foundation for a productive career in cancer cell biology. My ambitions are to attract talented students and integrate my many technical skills on Australian patients samples and to use model systems to further elucidate the mechanisms of disease.

Please contact me if you are interesting in joining my team.

Matt.Dun@newcastle.edu.au

Fields of Research

CodeDescriptionPercentage
111201Cancer Cell Biology40
110106Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics)30
060109Proteomics And Intermolecular Interactions (Excl. Medical Proteomics)30

Memberships

Committee/Associations (relevant to research).

  • Member - The Australian Society for Medical Research

Conference Chair

  • The Australian Society for Medical Research, Satellite Scientific Meeting Convenor

Collaboration

• Dr Nicole Verrills Medical Biochemistry, The University of Newcastle and HMRI.

• Prof Steve Ackland, Dr Jenntte Sakoff and Dr Jayne Gilbert, Medical Oncology, The Calvary Mater Hospital and HMRI.

• Dr Anoop Enjeti, Clinical Haematologist, The Calvary Mater Hospital.

• Prof Hubert Hondermarck, Professor of Medical Biochemistry, The University of Newcastle.

• Prof Martin Larsen, Institute of Biochemistry and Molecular Biology, The University of Southern Denmark.

• Prof Jonathan Morris and Hamish Toop, Chemistry Department, University of New South Wales.

• Prof Adam McCluskey, Chemistry Department, The University of Newcastle and Australian Cancer Research Foundation Centre for Kinomics.

• Nathan Smith, Analytical and Biomolecular Research Facility, Advanced Mass Spectrometry Unit, The University of Newcastle.

• Prof Richard Locke, Dr Anthony Don and Dr Anchit Khanna Lowy Cancer Research Centre, Prince of Wales Clinical School, Faculty of Medicine, The University of New South Wales.

Administrative

Administrative expertise

Professional memberships:

• 2014 –, Hunter Cancer Research Alliance Flagship Program in Implementation Scientific Committee Member

• 2014 –, Convenor of the Australian Society for Medical Research (ASMR) Satellite Scientific Meeting

• 2013 –, Committee Member of the Australian Society for Medical Research (ASMR)

• 2012 –, Member of the American Association of Cancer Research (AACR)

• 2012 –, Member of the Australian Leukaemia and Lymphoma Group (ALLG)

• 2012 –, Member of the Australian Society of Medical Research (ASMR)

• 2011 – 2012. Society of Reproductive Biology (SRB) Australian Student Representative to council

• 2010 – 2012. Young Investigators of Reproductive Biology Epididymis Council Co-Chair (International Society)

• 2010 – 2012. Priority Research Centre Reproductive Biology Meetings Co-Organiser (Reproductive Sciences, Eggs to Embryos and Mothers and Babies Groups)

• 2010. University of Newcastle Research Higher Degree Committee, Conference Organising Chair

Teaching

Teaching keywords

  • Biochemical Assays
  • Nucleic Acids
  • Protein Chemistry
  • Proteomics

Teaching expertise

• 2013: Lecturer, HUBS1202 Human Genomics and Biomolecular Analysis.

• 2013: Head Demonstrator, HUBS3302 Bioinformatics and Functional Genomics.

• 2012. Lecturer, HUBS1202 Human Genomics and Biomolecular Analysis.

• 2012: Head Demonstrator, HUBS3302 Bioinformatics and Functional Genomics.

• 2011: Lecturer and Head Demonstrator, BIOL2020 Animal Physiology & Development.

• 2011: Head Demonstrator, BIOL3020 Reproductive Physiology & Development head demonstrator.

• 2011: Demonstrator, BIOL3001 Advanced Laboratory Skills.

• 2010: Lecturer and Head Demonstrator, BIOL2020 Animal Physiology & Development.

• 2010: Head Demonstrator, BIOL3020 Reproductive Physiology & Development head demonstrator.

• 2010: Demonstrator, BIOL3001 Advanced Laboratory Skills.

• 2009: Head Demonstrator, BIOL2020 Animal Physiology & Development.

• 2009: Head Demonstrator, BIOL3020 Reproductive Physiology & Development head demonstrator.

• 2009: Demonstrator, BIOL3001 Advanced Laboratory Skills.

I am a lecturer for the Bachelor of Biomedical Science degree specifically, HUBS1202 Human Genomics and Biomolecular Analysis and HUBS3302 Bioinformatics and Functional Genomics. During my PhD I carried a significant teaching load, lecturing 2nd year Physiology for Biotech/Science students and spending almost 500 hours as Laboratory Head Demonstrator.

Also during my studies I played Rugby Union for the University of Newcastle and was awarded runner up for Sports Person of the Year, awarded a University Blue and represented NSW in rugby union for five consecutive years. I was also awarded the Representative Player of the Year for the Newcastle and Hunter Rugby Union and in the same year was awarded the NSW Country Rugby Union Championships Player of the Tournament.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2010Dun MD, Mitchell LA, Aitken RJ, Nixon B, 'Sperm-zona pellucida interaction: Molecular mechanisms and the potential for contraceptive intervention', Fertility Control, Springer, Berlin 139-178 (2010) [B1]

Journal article (9 outputs)

YearCitationAltmetricsLink
2014Goldie BJ, Dun MD, Lin M, Smith ND, Verrills NM, Dayas CV, Cairns MJ, 'Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons.', Nucleic Acids Research, 42 9195-9208 (2014) [C1]
2014Sadeqzadeh E, de Bock CE, Wojtalewicz N, Holt JE, Smith ND, Dun MD, et al., 'Furin processing dictates ectodomain shedding of human FAT1 cadherin.', Exp Cell Res, 323 41-55 (2014)
2014Sadeqzadeh E, De Bock CE, Holt JE, Dun MD, Thorne RF, Wojtalewicz N, et al., 'Furin processing dictates ectodomain shedding of human FAT1 cadherin', Experimental Cell Research, 323 41-55 (2014)
2014Hatchwell L, Girkin J, Morten M, Collison A, Mattes J, Foster PS, et al., 'Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A', Journal of Allergy and Clinical Immunology, 133 1720-1727 (2014)
2013Smith TB, Dun MD, Smith ND, Curry BJ, Connaughton HS, Aitken RJ, 'The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1', JOURNAL OF CELL SCIENCE, 126 1488-1497 (2013) [C1]
2012Dun MD, Anderson AL, Bromfield EG, Asquith KL, Emmett BJ, McLaughlin EA, et al., 'Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)', International Journal of Andrology, 35 572-589 (2012) [C1]
2012Dun MD, Aitken RJ, Nixon B, 'The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa', Human Reproduction Update, 18 420-435 (2012) [C1]
2011Redgrove KA, Anderson AL, Dun MD, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae', Developmental Biology, 356 460-474 (2011) [C1]
2011Dun MD, Smith ND, Baker MA, Lin M, Aitken RJ, Nixon B, 'The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction', Journal of Biological Chemistry, 286 36875-36887 (2011) [C1]
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Conference (4 outputs)

YearCitationAltmetricsLink
2013Dun MD, Smith AM, Kahl RGS, Smith ND, Khanna A, Don AS, et al., 'Unraveling the mechanism of action: drugs that activate the tumor suppressor 2A.', CANCER RESEARCH, Washington, DC (2013) [E3]
2012Aitken RJ, Nixon B, Redgrove KA, Dun M, Baker MA, 'The molecular origins of defective sperm function', HUMAN REPRODUCTION, Istanbul, TURKEY (2012) [E3]
2011Dun MD, Aitken JR, Nixon B, 'The CCT/TRiC Complex Is Involved in Mediating Sperm-Oocyte Interaction', BIOLOGY OF REPRODUCTION, Portland, OR (2011) [E3]
2010Dun MD, Aitken RJ, Nixon B, 'The Chaperonin Containing TCP-1 (CCT/TRIC) Multisubunit Complex is Involved in Mediating Sperm-Oocyte Interactions', Reproduction, Fertility and Development, Sydney (2010) [E3]
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Grants and Funding

Summary

Number of grants8
Total funding$1,082,096

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (4 grants)

Identifying novel therapeutic targets for the treatment of Acute Myeloid Leukaemia$600,000
Funding Body: Cancer Institute NSW

Project Team
Doctor Matt Dun, Doctor Nikki Verrills, Associate Professor Martin Larsen
SchemeRole
Early Career FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$600,00020142016
GNo:G1300952

Tetraspanin CD9; more than just an exosome marker - A novel biomarker to target for prostate cancer$300,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jude Weidenhofer, Doctor Kathryn Skelding, Doctor Matt Dun, Ms Belinda Goldie, Miss Danielle Bond
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$300,00020142016
GNo:G1400921

Defining the role of shwachman-bodien diamond syndrome protein (SBDS) in PP2A inhibition in acute myeloid leukaemia (AML).$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Matt Dun, Doctor Nikki Verrills
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020142014
GNo:G1301442

Identifying novel therapeutic targets for the treatment of Acute Myeloid Leukaemia$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Matt Dun, Doctor Nikki Verrills
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020142014
GNo:G1301353

2013 (3 grants)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Conjoint Associate Professor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Doctor Gabrielle Briggs, Emeritus Professor Leonie Ashman, Emeritus Professor John Rostas
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$24,59620132013
GNo:G1201189

Proteomics of Cancer$6,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Matt Dun, Doctor Nikki Verrills, Dr Anoop Enjeti
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$6,00020132013
GNo:G1300054

American Association of Cancer Research, Washington Convention Centre Washington DC USA, 6 - 10 April 2012$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Matt Dun
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020132013
GNo:G1201225

2012 (1 grants)

Cancer Institute of NSW Hunter Translation Cancer Research Fellowship$100,000
Funding Body: Cancer Institute NSW

SchemeRole
Translational Cancer Research UnitChief Investigator
Total AmountFunding StartFunding Finish
$100,00020122013
GNo:183139935
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Research Supervision

Number of current supervisions1
Total current UoN PhD EFTSL0.4

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Medical Biochemistry)Co-SupervisorIdentification of the Mechanism of Action of Anti-cancer Drugs Targeting Activation of the Tumour Suppressor, PP2A
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Dr Matthew (Matt) Dun

Work Phone(02) 4921 5693
Fax (02) 4921 6903
Email
PositionCancer Institute NSW EC Fellow
Molecular Oncology
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Office
LS3.33,
Life Sciences Building,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/matt-dun