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Dr Jay Horvat

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Career Summary

Biography

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Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Immunology
  • Pharmaceutical Sciences
  • Pharmacology

Fields of Research

CodeDescriptionPercentage
060599Microbiology not elsewhere classified15
111499Paediatrics and Reproductive Medicine not elsewhere classified15
110799Immunology not elsewhere classified70

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
25/03/2013 - 19/06/2013Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
16/07/2007 - 23/11/2007Casual AcademicUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
26/02/2007 - 31/12/2007LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (32 outputs)

YearCitationAltmetricsLink
2015Zouikr I, Ahmed AF, Horvat JC, Beagley KW, Clifton VL, Ray A, et al., 'Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity', Brain, Behavior, and Immunity, 44 235-246 (2015)

The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful experiences during this sensitive period of develop... [more]

The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful experiences during this sensitive period of development are known to produce long-lasting effects on the immune and nociceptive responses. It is less clear, however, whether inflammatory pain responses are primed by neonatal exposure to mild immunological stimuli, such as with lipopolysaccharide (LPS). Here, we examine the impact of neonatal LPS exposure on inflammatory pain responses, peripheral and hippocampal interleukin-1ß (IL-1ß), as well as mast cell number and degranulation in preadolescent and adult rats. Wistar rats were injected with LPS (0.05 mg/kg IP, Salmonella enteritidis) or saline on postnatal days (PNDs) 3 and 5 and later subjected to the formalin test at PNDs 22 and 80-97. At both time-points, and one-hour after formalin injection, blood and hippocampus were collected for measuring circulating and central IL-1ß levels using ELISA and Western blot, respectively. Paw tissue was also isolated to assess mast cell number and degree of degranulation using Toluidine Blue staining. Behavioural analyses indicate that at PND 22, LPS-challenged rats displayed enhanced flinching (p<.01) and licking (p<.01) in response to formalin injection. At PNDs 80-97, LPS-challenged rats exhibited increased flinching (p<.05), an effect observed in males only. Furthermore, neonatal LPS exposure enhanced circulating IL-1ß and mast cell degranulation in preadolescent but not adult rats following formalin injection. Hippocampal IL-1ß levels were increased in LPS-treated adult but not preadolescent rats in response to formalin injection. These data suggest neonatal LPS exposure produces developmentally regulated changes in formalin-induced behavioural responses, peripheral and central IL-1ß levels, as well as mast cell degranulation following noxious stimulation later in life. These findings highlight the importance of immune activation during the neonatal period in shaping immune response and pain sensitivity later in life. This is of clinical relevance given the high prevalence of bacterial infection during the neonatal period, particularly in the vulnerable population of preterm infants admitted to neonatal intensive care units.

DOI10.1016/j.bbi.2014.10.014
CitationsScopus - 1
Co-authorsPhilip Hansbro, Rick Thorne, Deborah Hodgson
2015Essilfie A-T, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', THORAX, 70 458-U151 (2015)
DOI10.1136/thoraxjnl-2014-206067Author URL
CitationsWeb of Science - 1
Co-authorsPhilip Hansbro, Jodie Simpson, Paul Foster, Peter Gibson, Malcolm Starkey
2015Singanayagam A, Glanville N, Walton RP, Aniscenko J, Pearson RM, Pinkerton JW, et al., 'A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.', Clin Sci (Lond), 129 245-258 (2015)
DOI10.1042/CS20140654Author URL
Co-authorsPhilip Hansbro
2014Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.', Mucosal Immunol, 7 478-488 (2014) [C1]
DOI10.1038/mi.2013.65Author URL
CitationsScopus - 1
Co-authorsMalcolm Starkey, Philip Hansbro, Joerg Mattes, Paul Foster
2014O'Reilly M, Hansbro PM, Horvat JC, Beckett EL, Harding R, Sozo F, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', Anatomical Record, 297 758-769 (2014) [C1]

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces ... [more]

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces persistent changes in small conducting airways (bronchioles). Although the effects of neonatal hyperoxia on alveolarization are well documented, little is known about its effects on developing bronchioles. We hypothesized that neonatal hyperoxia would remodel the bronchiolar walls, contributing to altered lung function in adulthood. We studied three groups of mice (C57BL/6J) to postnatal day 56 (P56; adulthood) when they either underwent lung function testing or necropsy for histological analysis of the bronchiolar wall. One group inhaled 65% O2 from birth until P7, after which they breathed room air; this group experienced growth restriction (HE+GR group). We also used a group in which hyperoxia-induced GR was prevented by dam rotation (HE group). A control group inhaled room air from birth. At P56, the bronchiolar epithelium of HE mice contained fewer Clara cells and more ciliated cells, and the bronchiolar wall contained ~25% less collagen than controls; in HE+GR mice the bronchiolar walls had ~13% more collagen than controls. Male HE and HE+GR mice had significantly thicker bronchiolar epithelium than control males and altered lung function (HE males: greater dynamic compliance; HE+GR males: lower dynamic compliance). We conclude that neonatal hyperoxia remodels the bronchiolar wall and, in adult males, affects lung function, but effects are altered by concomitant growth restriction. Our findings may partly explain the reports of poor lung function in ex-preterm children and adults. Anat Rec, 297:758-769, 2014. © 2014 Wiley Periodicals, Inc.

DOI10.1002/ar.22867
CitationsWeb of Science - 1
Co-authorsPhilip Hansbro
2014O'Reilly M, Harding R, Sozo F, Hansbro PM, Horvat JC, Beckett EL, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', Anatomical Record, 297 758-769 (2014)
DOI10.1002/ar.22867
Co-authorsPhilip Hansbro
2014Hansbro PM, Starkey MR, Mattes J, Horvat JC, 'Pulmonary immunity during respiratory infections in early life and the development of severe asthma', Annals of the American Thoracic Society, 11 S297-S302 (2014) [C1]

Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation... [more]

Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) to normally innocuous antigens. Combination therapies with inhaled corticosteroids and bronchodilators effectively manage mild to moderate asthma, but there are no cures, and patients with severe asthma do not respond to these treatments. The inception of asthma is linked to respiratory viral (respiratory syncytial virus, rhinovirus) and bacterial (Chlamydia, Mycoplasma) infections. The examination of mouse models of early-life infections and allergic airway disease (AAD) provides valuable insights into the mechanisms of disease inception that may lead to the development of more effective therapeutics. For example, early-life, but not adult, Chlamydia respiratory infections in mice permanently modify immunity and lung physiology. This increases the severity of AAD by promoting IL-13 expression, mucus hypersecretion, and AHR. We have identified novel roles for tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and IL-13 in promoting infection-induced pathology in early life and subsequent chronic lung disease. Genetic deletion of TRAIL or IL-13 variously protected against neonatal infection-induced inflammation, mucus hypersecretion, altered lung structure, AHR, and impaired lung function. Therapeutic neutralization of these factors prevented infection-induced severe AAD. Other novel mechanisms and avenues for intervention are also being explored. Such studies indicate the immunological mechanisms that may underpin the association between early-life respiratory infections and the development of more severe asthma and may facilitate the development of tailored preventions and treatments.

DOI10.1513/AnnalsATS.201402-086AW
Co-authorsJoerg Mattes, Philip Hansbro, Malcolm Starkey
2013Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S, 'Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.', Front Immunol, 4 272 (2013) [C1]
DOI10.3389/fimmu.2013.00272Author URL
CitationsScopus - 7Web of Science - 4
Co-authorsSimon Keely
2013Starkey MR, Nguyen DH, Kim RY, Nair PM, Brown AC, Essifie A-T, et al., 'Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease', CLINICAL OBSTETRICS AND GYNECOLOGY, 56 566-576 (2013) [C1]
DOI10.1097/GRF.0b013e3182993a0cAuthor URL
CitationsScopus - 2Web of Science - 1
Co-authorsMalcolm Starkey, Philip Hansbro
2013Fung KY, Mangan NE, Cumming H, Horvat JC, Mayall JR, Stifter SA, et al., 'Interferon-epsilon Protects the Female Reproductive Tract from Viral and Bacterial Infection', SCIENCE, 339 1088-1092 (2013) [C1]
DOI10.1126/science.1233321Author URL
CitationsScopus - 29Web of Science - 35
Co-authorsPhilip Hansbro
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
CitationsScopus - 29Web of Science - 30
Co-authorsNicole Hansbro, Paul Foster, Ming Yang, Philip Hansbro, Simon Keely, Peter Wark
2013Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
CitationsScopus - 18Web of Science - 13
Co-authorsMing Yang, Malcolm Starkey, Paul Foster, Philip Hansbro
2013Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC, et al., 'Murine models of infectious exacerbations of airway inflammation', CURRENT OPINION IN PHARMACOLOGY, 13 337-344 (2013) [C1]
DOI10.1016/j.coph.2013.03.005Author URL
CitationsScopus - 6Web of Science - 7
Co-authorsPaul Foster, Philip Hansbro, Malcolm Starkey
2013Starkey MR, Essilfie A-T, Horvat JC, Kim RY, Nguyen DH, Beagley KW, et al., 'Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease', Mucosal Immunology, 6 569-579 (2013) [C1]
CitationsScopus - 8Web of Science - 4
Co-authorsPaul Foster, Joerg Mattes, Philip Hansbro, Malcolm Starkey
2012Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors', Developmental Psychobiology, 54 568-575 (2012) [C1]
CitationsScopus - 1Web of Science - 1
Co-authorsVicki Clifton, Deborah Hodgson, Philip Hansbro, Roger Smith, Olivia Wynne
2012Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM, 'TLR2, but not TLR4, is required for effective host defence against chlamydia respiratory tract infection in early life', PLOS One, 7 e39460 (2012) [C1]
CitationsScopus - 17Web of Science - 16
Co-authorsMalcolm Starkey, Philip Hansbro, Paul Foster
2012Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie A-T, et al., 'Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice', PLoS One, 7 e42588 (2012) [C1]
CitationsScopus - 7Web of Science - 6
Co-authorsJoerg Mattes, Philip Hansbro, Malcolm Starkey
2012Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC, 'Programming of the lung by early-life infection', Journal of Developmental Origins of Health and Disease, 3 153-158 (2012) [C1]
CitationsScopus - 4Web of Science - 4
Co-authorsPaul Foster, Philip Hansbro, Malcolm Starkey
2011Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authorsMargaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson, Paul Foster
2011Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 e1001339 (2011) [C1]
CitationsScopus - 24Web of Science - 20
Co-authorsPhilip Hansbro, Paul Foster
2011Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
DOI10.1016/j.bbi.2011.03.014
CitationsScopus - 3Web of Science - 3
Co-authorsVicki Clifton, Olivia Wynne, Linkooi Ong, Deborah Hodgson, Roger Smith, Philip Hansbro
2011Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI10.1183/09031936.00049510
CitationsScopus - 31Web of Science - 29
Co-authorsPaul Foster, Peter Gibson, Malcolm Starkey, Philip Hansbro
2011Wynne OL, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner', Stress-the International Journal on the Biology of Stress, 14 247-261 (2011) [C1]
DOI10.3109/10253890.2010.532576
CitationsScopus - 9Web of Science - 9
Co-authorsRoger Smith, Philip Hansbro, Vicki Clifton, Deborah Hodgson, Olivia Wynne
2010Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI10.4049/jimmunol.0902287
CitationsScopus - 40Web of Science - 35
Co-authorsMalcolm Starkey, Philip Hansbro, Peter Gibson, Paul Foster
2010Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI10.1016/j.jaci.2009.10.018
Co-authorsMalcolm Starkey, Philip Hansbro, Peter Gibson, Paul Foster
2010Starkey MR, Horvat JC, Kim RY, Hansbro PM, 'Reply', Journal of Allergy and Clinical Immunology, 125 1415 (2010) [C3]
DOI10.1016/j.jaci.2010.03.033
Co-authorsMalcolm Starkey, Philip Hansbro
2008Kaiko GE, Horvat JC, Beagley KW, Hansbro PM, 'Immunological decision-making: How does the immune system decide to mount a helper T-cell response?', Immunology, 123 326-338 (2008) [C1]
DOI10.1111/j.1365-2567.2007.02719.x
CitationsScopus - 125Web of Science - 116
Co-authorsPhilip Hansbro
2008Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
DOI10.1016/j.pharmthera.2007.11.002
CitationsScopus - 57Web of Science - 50
Co-authorsPhilip Hansbro, Peter Wark, Nicole Hansbro
2007Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI10.1164/rccm.200607-1005OC
CitationsScopus - 45Web of Science - 44
Co-authorsPaul Foster, Peter Gibson, Nicole Hansbro, Philip Hansbro
2007Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
DOI10.1016/j.vaccine.2007.09.034
CitationsScopus - 28Web of Science - 27
Co-authorsPaul Foster, Peter Gibson, Philip Hansbro
2006Skelding KA, Hickey DK, Horvat JC, Bao SS, Roberts KG, Read JM, et al., 'Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection', Vaccine, 24 355-366 (2006) [C1]
DOI10.1016/j.vaccine.2005.07.104
CitationsScopus - 28Web of Science - 26
Co-authorsKathryn Skelding, Philip Hansbro
2004Hansbro PM, Beagley KW, Horvat JC, Gibson PG, 'Role of atypical bacterial infection of the lung in predisposition/protection of asthma', Pharmacology and Therapeutics, 101 193-210 (2004) [C1]
DOI10.1016/j.pharmthera.2003.10.007
CitationsScopus - 63Web of Science - 54
Co-authorsPhilip Hansbro, Peter Gibson
Show 29 more journal articles

Conference (53 outputs)

YearCitationAltmetricsLink
2014Goggins B, Minahan K, Marks E, Mateer S, Cardona J, Knight D, et al., 'Hypoxia inducible factor (HIF)-1 accelerates epithelial wound healing through integrin regulation', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsDarryl Knight
2014Cardona J, Marks E, Goggins B, Mateer S, Minahan K, Horvat J, Keely S, 'The role of antibiotics in the development of food allergy', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsSimon Keely
2014Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsSimon Keely, Philip Hansbro, Steven Maltby
2014Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI10.1016/j.cyto2014.07.182Author URL
Co-authorsPeter Wark, Malcolm Starkey, Philip Hansbro, Darryl Knight, Alan Hsu, Paul Foster
2014Horvat J, Kim R, Mayall J, Pinkerton J, Starkey M, Essilfie A, et al., 'ANTIOXIDANT-BASED THERAPY FOR THE SUPPRESSION OF EARLY- LIFE INFECTION-INDUCED SEVERE ASTHMA', RESPIROLOGY (2014) [E3]
DOI10.1111/resp.12263_2Author URL
Co-authorsMalcolm Starkey, Philip Hansbro, Lisa Wood
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsPhilip Hansbro, Ming Yang, Nicole Hansbro, Simon Keely, Paul Foster, Peter Wark
2013Hansbro P, Horvat J, Essilfie A-T, Kim R, Mayall J, Starkey M, Foster P, 'Macrolides suppress key features of experimental steroid-sensitive and steroid-resistant asthma', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsMalcolm Starkey, Paul Foster, Philip Hansbro
2013Kim RY, Horvat JC, Starkey MR, Essilfie A-T, Foster PS, Hansbro PM, 'MICRORNA INHIBITION IN NEONATAL CHLAMYDIA LUNG INFECTION PREVENTS INFECTION-INDUCED LUNG PATHOLOGY IN LATER LIFE', RESPIROLOGY (2013) [E3]
Author URL
Co-authorsPaul Foster, Philip Hansbro, Malcolm Starkey
2013Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Author URL
CitationsScopus - 1
Co-authorsPeter Gibson, Philip Hansbro, Malcolm Starkey, Paul Foster
2012Stifter SA, Fung K, Horvat JC, Hansbro PM, De Weerd NA, Hertzog PJ, 'Expression, purification and biological characterisation of a novel type I interferon, IFN epsilon', Immunology, Glasgow, Scotland (2012) [E3]
Co-authorsPhilip Hansbro
2012Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'Efficacy of antibiotic-based therapeutic strategies for the treatment of infection-induced, steroid-resistant allergic airways disease', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPhilip Hansbro, Paul Foster, Malcolm Starkey
2012Starkey MR, Kim RY, Horvat JC, Essilfie A-T, Beagley KW, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection-induced chronic airway hyperresponsiveness', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPhilip Hansbro, Malcolm Starkey, Joerg Mattes, Paul Foster
2011O'Reilly M, Hansbro PM, Horvat JC, Sozo F, Harding R, 'Inhalation of hyperoxic gas in the neonatal period has long-term effects on the pulmonary airways', Journal of Developmental Origins of Health and Disease, Portland, Oregon (2011) [E3]
Co-authorsPhilip Hansbro
2011Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
Co-authorsDeborah Hodgson, Philip Hansbro, Roger Smith, Linkooi Ong
2011Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authorsMargaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson, Paul Foster
2011Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
Co-authorsMargaret Dunkley, Philip Hansbro, Jodie Simpson, Paul Foster, Peter Gibson
2010Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
CitationsScopus - 37Web of Science - 34
Co-authorsJodie Simpson, Philip Hansbro, Paul Foster, Margaret Dunkley, Peter Gibson
2010O'Reilly M, Harding R, Beckett EL, Horvat JC, Hansbro PM, Sozo F, 'Exposure of the immature mouse lung to hyperoxic gas: do structural changes in the lung cause long-term changes in lung function?', 24th Fetal and Neonatal Physiology Workshop of Australia and New Zealand. Program and Abstracts, Wellington, NZ (2010) [E3]
Co-authorsPhilip Hansbro
2010Fung K, Cumming H, Mangan N, Horvat JC, Hansbro PM, Hertzog P, 'Interferon epsilon regulates reproductive tract immunity to Chlamydia infection', Journal of Reproductive Immunology, Palm Cove, QLD (2010) [E3]
Co-authorsPhilip Hansbro
2009Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology, Seattle, WASH. (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
Co-authorsPaul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authorsPaul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009Fung KY, Cumming H, Mangan N, Stifter S, Horvat JC, Hansbro PM, Hertzog PJ, 'Characterisation of a novel, constitutive cytokine that regulates mucosal immunity in the reproductive tract', Cytokine, Lisbon, Portugal (2009) [E3]
DOI10.1016/j.cyto.2009.07.324
Co-authorsPhilip Hansbro
2009Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology, Darwin, NT (2009) [E3]
DOI10.1111/j.1440-1843.2009.01503_1.x
Co-authorsPaul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology, Darwin, NT (2009) [E3]
DOI10.1016/j.jaci.2009.10.018
CitationsScopus - 46Web of Science - 46
Co-authorsPaul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2008Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor, mineralocorticoid receptor and corticotrophin releasing hormone mRNA abundance', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsRoger Smith, Philip Hansbro, Deborah Hodgson, Olivia Wynne, Vicki Clifton
2008Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authorsPaul Foster, Philip Hansbro, Peter Gibson
2008Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPeter Gibson, Paul Foster, Philip Hansbro
2008Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPaul Foster, Margaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson
2008Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor and mineralocorticoid receptor abundance', 15th Annual Meeting of the Psychoneuroimmunology Research Society: Program, Madison, WISC (2008) [E3]
Co-authorsOlivia Wynne, Philip Hansbro, Roger Smith, Vicki Clifton, Deborah Hodgson
2008Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authorsPeter Gibson, Philip Hansbro, Malcolm Starkey, Paul Foster
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsPeter Gibson, Philip Hansbro, Paul Foster
2007Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authorsNicole Hansbro, Peter Gibson, Paul Foster, Philip Hansbro
2007Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal corticosterone receptor abundance and circulating corticosterone', Early Human Development, Perth (2007) [E3]
Co-authorsDeborah Hodgson, Vicki Clifton, Philip Hansbro, Roger Smith, Olivia Wynne
2007Wynne OL, Horvat JC, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of postnatal stress on neuroendocrine development and function in adulthood in the mouse', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts, Melbourne, VIC (2007) [E3]
Co-authorsVicki Clifton, Deborah Hodgson, Philip Hansbro, Olivia Wynne
2007Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authorsPaul Foster, Peter Gibson, Jodie Simpson, Philip Hansbro, Margaret Dunkley
2007Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI10.1111/j.1440-1843.2007.001050.x
Co-authorsPhilip Hansbro, Nicole Hansbro, Peter Gibson, Paul Foster
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Paul Foster
2006Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPeter Gibson, Philip Hansbro, Paul Foster
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsPeter Gibson, Paul Foster, Philip Hansbro
2006Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authorsNicole Hansbro, Philip Hansbro, Peter Gibson, Paul Foster
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology, Canberra (2006) [E3]
Co-authorsPaul Foster, Peter Gibson, Nicole Hansbro, Philip Hansbro
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology, Canberra (2006) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Paul Foster
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsPhilip Hansbro, Nicole Hansbro, Paul Foster, Peter Gibson
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Paul Foster
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Paul Foster
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authorsPhilip Hansbro, Peter Gibson, Paul Foster
2005Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS, Melbourne, AUSTRALIA (2005)
Author URL
Co-authorsPhilip Hansbro, Peter Gibson, Paul Foster
2005Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens, Melbourne, Australia (2005) [E3]
CitationsWeb of Science - 1
Co-authorsPaul Foster, Peter Gibson, Philip Hansbro
2005Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research, Melbourne, Australia (2005) [E3]
Co-authorsNicole Hansbro, Peter Gibson, Paul Foster, Philip Hansbro
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsPeter Gibson, Paul Foster, Philip Hansbro
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authorsPaul Foster, Philip Hansbro, Peter Gibson
2005Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Combined transcutaneous and intranasal immunisation protects against genital tract Chlamydial infection', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts, USA. (2005) [E3]
Co-authorsPhilip Hansbro, Kathryn Skelding
2005Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Comparison of intranasal and transcutaneous immunisation for the protection against Chlamydial pneumonia', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts (2005) [E3]
Co-authorsKathryn Skelding, Philip Hansbro
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Grants and Funding

Summary

Number of grants19
Total funding$1,348,984

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $20,000

Investigation of the progression of Alzheimers Disease: Identification of potential drivers of disease$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat, Associate Professor Liz Milward, Professor Phil Hansbro, Dr Daniel Johnstone
SchemeProject Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500589
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20143 grants / $751,417

Interferon epsilon for Chlamydia RTIs $729,817

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Doctor Jay Horvat, Professor Paul Hertzog
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300071
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The role of the microbiome in the development of food allergy$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Simon Keely, Doctor Jay Horvat
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301344
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Adelaide AUS, 4-9 April 2014$1,600

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Jay Horvat
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400305
Type Of FundingInternal
CategoryINTE
UONY

20134 grants / $392,942

Elucidating the mechanisms of infection-induced, steroid-resistant asthma$336,057

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Jay Horvat
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1200073
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201186
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Thoracic Society of Australia & New Zealand ASM, Darwin Convention Centre, 22 - 27 March 2013$1,885

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Jay Horvat
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300883
Type Of FundingInternal
CategoryINTE
UONY

20123 grants / $66,500

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100975
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Elucidating the mechanisms of steroid-resistant asthma$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
SchemeResearch Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200190
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Thoracic Society of Australia and New Zealand, Canberra, 31 March - 4 April 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Jay Horvat
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200427
Type Of FundingInternal
CategoryINTE
UONY

20113 grants / $61,625

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Antioxidant therapies for suppressing infection-induced asthma in children$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat, Associate Professor Lisa Wood, Professor Phil Hansbro
SchemeYouth Research Project Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001002
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Thoracic Society of Australia & New Zealand ASM 2011, Perth Convention & Exhibition Centre, Perth WA, 2-4 April 2011$1,625

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Jay Horvat
SchemeTravel Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100399
Type Of FundingInternal
CategoryINTE
UONY

20101 grants / $25,000

Improved Treatment Strategies for Infection-Induced Neutrophilic Asthma$25,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamDoctor Jay Horvat
SchemeResearch Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900078
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20093 grants / $26,500

Immunisation against chlamydia-associated asthma$20,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
SchemeResearch Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189629
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jay Horvat
SchemePULSE Education Prize
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189892
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

American Association of Immunologists and American Thoracic Society, Seattle USA, 8-21 May 2009$2,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Jay Horvat
SchemeTravel Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0190127
Type Of FundingInternal
CategoryINTE
UONY

20041 grants / $5,000

Modulation of asthma by chlamydial infection at different ages$5,000

Funding body: Asthma Foundation of New South Wales

Funding bodyAsthma Foundation of New South Wales
Project TeamDoctor Jay Horvat, Professor Phil Hansbro, Conjoint Professor Kenneth Beagley
SchemePhD Scholarships
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183717
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Fatty Acids and Bronchodilator Responses
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015Neuropathological Effects of Putative Modifiers of Alzheimer's Disease Risk and Progression: Investigation in Mouse Models
Health, Faculty of Health and Medicine
Co-Supervisor
2015Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015Investigation of Novel Immune Molecules in the Pathogenesis of Female Chlamydia Genital Tract Infections
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015To assess the role of IFNe in modulating innate immune responses and protecting against Chlamydia infection in human tissues
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014Hypoxia Inducible Factor (HIF)-1 mediates epithelial wound healing through integrin regulation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014Effect of Iron loading on vision in a mouse model of haemochromatosis
Health, Faculty of Health and Medicine
Co-Supervisor
2014Investigating the Inter-Relationship between Iron Homeostasis and Infection in the Pathogenesis of Disease
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2013Role of TLR/IL-13/STAT6/PI3K Response in Early-life Respiratory Infection and Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013Elucidating the Mechanisms of Infection-Induced, Steroid-Resistant Asthma
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2013Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011The Role of Interferon Epsilon in Protection Against Chlamydial Reproductive Tract Infections
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Mechanisms of Predisposition to Secondary Bacterial Pneumonia
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Immunoregulatory Therapies for Inflammatory Diseases
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011The Roles of Fibulin-1 in Airway Remodelling in Lung Diseases
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011Identifying the Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2010Indentification of New Therapeutics in COPD/ Emphysema
Microbiology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Investigation of the Mechanisms of Respiratory Infection- Induced Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014Immune Mechanisms that Underpin Early-Life Chlamydia Respiratory Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
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News

HMRI logo

Newcastle researchers help in fight against STDs

March 1, 2013

Newcastle researchers have contributed to the discovery of a protein in the female reproductive tract that protects against sexually transmitted diseases (STDs) such as chlamydia and herpes simplex virus (HSV).

Dr Jay Horvat

Position

Senior Lecturer
Inflammation and infection-induced diseases research group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Emailjay.horvat@newcastle.edu.au
Phone(02) 40 420220
Fax(02) 40 420026

Office

RoomLevel 2, East Wing HMRI Building
BuildingHMRI Building
LocationOther

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