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Career Summary

Biography

I completed my PhD in the lab of A/Prof Phil Hansbro in December 2008 and a played a major role in establishing a research programme that focuses on the link between chlamydial respiratory infection and asthma.

I showed for the first time using mouse models that chlamydial infections in early life, but not adulthood, result in permanent damage to lung tissue and adverse changes in immune responses. These infection-induced alterations result in worsened mucus production and deteriorated lung function during allergic airways disease in adulthood. These findings suggest that early life chlamydial lung infections may predispose individuals to worsened asthma in later life.

I have also shown that an ongoing, but not cleared infection during allergic airways disease in adults, results in the induction of a neutrophilic inflammatory response that resembles neutrophilic asthma in humans. These findings suggest that chlamydial lung infection may induce immune responses in asthmatics that have similarities to responses in neutrophilic asthma. These observations have important implications to clinical disease. Neutrophilic asthmatics have proven difficult to treat as they are relatively resistant to steroid treatment, which is the mainstay of asthma therapy. Elucidation of the mechanisms behind the infection-induced pathophysiological changes that I have observed may inform the development of more effective infection-specific treatments for infection-induced neutrophilic asthma in humans.

In addition to continuing on with my work with chlamydial infection, I am also investigating the association between a number of other common respiratory infections (both bacterial & viral) and the development and exacerbation of asthma and chronic obstructive pulmonary disease (COPD).

My overarching aim is to develop superior therapies for infection-induced disease.

Qualifications

  • Doctor of Philosophy, University of Newcastle, 18/12/2008
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle, 15/12/2003

Research

Research keywords

  • Immunology
  • Pharmaceutical Sciences
  • Pharmacology

Research expertise

Focus area: Immunology and Microbiology

Fields of Research

CodeDescriptionPercentage
110700Immunology70
060599Microbiology Not Elsewhere Classified15
111499Paediatrics And Reproductive Medicine Not Elsewhere Classified15
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (27 outputs)

YearCitationAltmetricsLink
2014Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.', Mucosal Immunol, 7 478-488 (2014)
2014O'Reilly M, Hansbro PM, Horvat JC, Beckett EL, Harding R, Sozo F, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 297 758-769 (2014)
2013Fung KY, Mangan NE, Cumming H, Horvat JC, Mayall JR, Stifter SA, et al., 'Interferon-epsilon Protects the Female Reproductive Tract from Viral and Bacterial Infection', SCIENCE, 339 1088-1092 (2013) [C1]
2013Starkey MR, Nguyen DH, Kim RY, Nair PM, Brown AC, Essifie A-T, et al., 'Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease', CLINICAL OBSTETRICS AND GYNECOLOGY, 56 566-576 (2013) [C1]
2013Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC, et al., 'Murine models of infectious exacerbations of airway inflammation', CURRENT OPINION IN PHARMACOLOGY, 13 337-344 (2013) [C1]
2013Starkey MR, Essilfie A-T, Horvat JC, Kim RY, Nguyen DH, Beagley KW, et al., 'Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease', Mucosal Immunology, 6 569-579 (2013) [C1]
2013Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S, 'Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.', Front Immunol, 4 272 (2013) [C1]
2013Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
2012Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC, 'Programming of the lung by early-life infection', Journal of Developmental Origins of Health and Disease, 3 153-158 (2012) [C1]
2012Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors', Developmental Psychobiology, 54 568-575 (2012) [C1]
2012Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM, 'TLR2, but not TLR4, is required for effective host defence against chlamydia respiratory tract infection in early life', PLOS One, 7 e39460 (2012) [C1]
2012Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie A-T, et al., 'Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice', PLoS One, 7 e42588 (2012) [C1]
2011Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
2011Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
2011Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
2011Wynne OL, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner', Stress-the International Journal on the Biology of Stress, 14 247-261 (2011) [C1]
2011Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 e1001339 (2011) [C1]
2010Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
2010Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
2010Starkey MR, Horvat JC, Kim RY, Hansbro PM, 'Reply', Journal of Allergy and Clinical Immunology, 125 1415 (2010) [C3]
2008Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
2008Kaiko GE, Horvat JC, Beagley KW, Hansbro PM, 'Immunological decision-making: How does the immune system decide to mount a helper T-cell response?', Immunology, 123 326-338 (2008) [C1]
2007Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
2007Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
2006Skelding KA, Hickey DK, Horvat JC, Bao SS, Roberts KG, Read JM, et al., 'Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection', Vaccine, 24 355-366 (2006) [C1]
2004Hansbro PM, Beagley KW, Horvat JC, Gibson PG, 'Role of atypical bacterial infection of the lung in predisposition/protection of asthma', Pharmacology and Therapeutics, 101 193-210 (2004) [C1]
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Conference (49 outputs)

YearCitationAltmetricsLink
2014Horvat J, Kim R, Mayall J, Pinkerton J, Starkey M, Essilfie A, et al., 'ANTIOXIDANT-BASED THERAPY FOR THE SUPPRESSION OF EARLY- LIFE INFECTION-INDUCED SEVERE ASTHMA', RESPIROLOGY (2014)
2013Hansbro P, Horvat J, Essilfie A-T, Kim R, Mayall J, Starkey M, Foster P, 'Macrolides suppress key features of experimental steroid-sensitive and steroid-resistant asthma', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
2013Kim RY, Horvat JC, Starkey MR, Essilfie A-T, Foster PS, Hansbro PM, 'MICRORNA INHIBITION IN NEONATAL CHLAMYDIA LUNG INFECTION PREVENTS INFECTION-INDUCED LUNG PATHOLOGY IN LATER LIFE', RESPIROLOGY (2013) [E3]
2013Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
2012Starkey MR, Kim RY, Horvat JC, Essilfie A-T, Beagley KW, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection-induced chronic airway hyperresponsiveness', Respirology, Canberra, ACT (2012) [E3]
2012Stifter SA, Fung K, Horvat JC, Hansbro PM, De Weerd NA, Hertzog PJ, 'Expression, purification and biological characterisation of a novel type I interferon, IFN epsilon', Immunology, Glasgow, Scotland (2012) [E3]

Co-authors: Philip Hansbro

2012Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'Efficacy of antibiotic-based therapeutic strategies for the treatment of infection-induced, steroid-resistant allergic airways disease', Respirology, Canberra, ACT (2012) [E3]
2011O'Reilly M, Hansbro PM, Horvat JC, Sozo F, Harding R, 'Inhalation of hyperoxic gas in the neonatal period has long-term effects on the pulmonary airways', Journal of Developmental Origins of Health and Disease, Portland, Oregon (2011) [E3]

Co-authors: Philip Hansbro

2011Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
2011Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
2011Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2010O'Reilly M, Harding R, Beckett EL, Horvat JC, Hansbro PM, Sozo F, 'Exposure of the immature mouse lung to hyperoxic gas: do structural changes in the lung cause long-term changes in lung function?', 24th Fetal and Neonatal Physiology Workshop of Australia and New Zealand. Program and Abstracts, Wellington, NZ (2010) [E3]

Co-authors: Philip Hansbro

2010Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
2010Fung K, Cumming H, Mangan N, Horvat JC, Hansbro PM, Hertzog P, 'Interferon epsilon regulates reproductive tract immunity to Chlamydia infection', Journal of Reproductive Immunology, Palm Cove, QLD (2010) [E3]

Co-authors: Philip Hansbro

2009Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology, Darwin, NT (2009) [E3]
2009Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology, Seattle, WASH. (2009) [E3]
2009Fung KY, Cumming H, Mangan N, Stifter S, Horvat JC, Hansbro PM, Hertzog PJ, 'Characterisation of a novel, constitutive cytokine that regulates mucosal immunity in the reproductive tract', Cytokine, Lisbon, Portugal (2009) [E3]
2009Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology, Darwin, NT (2009) [E3]
2009Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology, Seattle, WASH. (2009) [E3]
2008Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
2008Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology, Melbourne, VIC (2008) [E3]
2008Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
2008Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
2008Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor and mineralocorticoid receptor abundance', 15th Annual Meeting of the Psychoneuroimmunology Research Society: Program, Madison, WISC (2008) [E3]
2008Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor, mineralocorticoid receptor and corticotrophin releasing hormone mRNA abundance', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
2007Wynne OL, Horvat JC, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of postnatal stress on neuroendocrine development and function in adulthood in the mouse', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts, Melbourne, VIC (2007) [E3]
2007Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
2007Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
2007Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
2007Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal corticosterone receptor abundance and circulating corticosterone', Early Human Development, Perth (2007) [E3]
2007Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
2006Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology, Canberra (2006) [E3]
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology, Canberra (2006) [E3]
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
2006Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
2006Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
2006Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
2006Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
2005Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Combined transcutaneous and intranasal immunisation protects against genital tract Chlamydial infection', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts, USA. (2005) [E3]
2005Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
2005Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens, Melbourne, Australia (2005) [E3]
2005Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Comparison of intranasal and transcutaneous immunisation for the protection against Chlamydial pneumonia', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts (2005) [E3]
2005Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research, Melbourne, Australia (2005) [E3]
2005Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS, Melbourne, AUSTRALIA (2005)
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Grants and Funding

Summary

Number of grants18
Total funding$1,328,984

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (3 grants)

Interferon epsilon for Chlamydia RTIs $729,817
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Doctor Jay Horvat, Professor Paul Hertzog
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$729,81720142017
GNo:G1300071

The role of the microbiome in the development of food allergy$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Simon Keely, Doctor Jay Horvat
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1301344

Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Adelaide AUS, 4-9 April 2014$1,600
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Jay Horvat
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,60020142014
GNo:G1400305

2013 (4 grants)

Elucidating the mechanisms of infection-induced, steroid-resistant asthma$336,057
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Jay Horvat
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$336,05720132015
GNo:G1200073

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1201186

Thoracic Society of Australia & New Zealand ASM, Darwin Convention Centre, 22 - 27 March 2013$1,885
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Jay Horvat
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,88520132013
GNo:G1300883

2012 (3 grants)

SpectraMax M5e Multi-Mode Microplate Reader$50,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$50,00020122012
GNo:G1100975

Elucidating the mechanisms of steroid-resistant asthma$15,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jay Horvat, Professor Phil Hansbro, Professor Paul Foster
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020122012
GNo:G1200190

Thoracic Society of Australia and New Zealand, Canberra, 31 March - 4 April 2012$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Jay Horvat
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020122012
GNo:G1200427

2011 (3 grants)

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$45,00020112011
GNo:G1100037

Antioxidant therapies for suppressing infection-induced asthma in children$15,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jay Horvat, Associate Professor Lisa Wood, Professor Phil Hansbro
SchemeRole
Youth Research Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020112011
GNo:G1001002

Thoracic Society of Australia & New Zealand ASM 2011, Perth Convention & Exhibition Centre, Perth WA, 2-4 April 2011$1,625
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Jay Horvat
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,62520112011
GNo:G1100399

2010 (1 grants)

Improved Treatment Strategies for Infection-Induced Neutrophilic Asthma$25,000
Funding Body: Asthma Foundation of New South Wales

Project Team
Doctor Jay Horvat
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020102010
GNo:G0900078

2009 (3 grants)

Immunisation against chlamydia-associated asthma$20,000
Funding Body: Rebecca L Cooper Medical Research Foundation Ltd

Project Team
Doctor Jay Horvat, Professor Phil Hansbro, Professor Paul Foster
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020092009
GNo:G0189629

PULSE Education Prize$4,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jay Horvat
SchemeRole
PULSE Education PrizeChief Investigator
Total AmountFunding StartFunding Finish
$4,00020092009
GNo:G0189892

American Association of Immunologists and American Thoracic Society, Seattle USA, 8-21 May 2009$2,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Jay Horvat
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020092009
GNo:G0190127

2004 (1 grants)

Modulation of asthma by chlamydial infection at different ages$5,000
Funding Body: Asthma Foundation of New South Wales

Project Team
Doctor Jay Horvat, Professor Phil Hansbro, Conjoint Professor Kenneth Beagley
SchemeRole
PhD ScholarshipsChief Investigator
Total AmountFunding StartFunding Finish
$5,00020042004
GNo:G0183717
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Research Supervision

Number of current supervisions14
Total current UoN Masters EFTSL0.1
Total current UoN PhD EFTSL3

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Immunology & Microbiol)Principal SupervisorInvestigating the Inter-Relationship between Iron Homeostasis and Infection in the Pathogenesis of Disease
20142018PhD (Immunology & Microbiol)Co-SupervisorHypoxic Regulation of Integrin Beta1 During Mucosal Wound Healing
20142018PhD (Medical Genetics)Co-SupervisorInvestigation of the effects of the common oxidant risk factors iron and smoking on the retina and the brain
20132015M Philosophy (Immun & Microbi)Co-SupervisorRole of Innate Immune Cells in the Pathogenesis of COPD
20132017PhD (Immunology & Microbiol)Principal SupervisorElucidating the Mechanisms of Infection-Induced, Steroid-Resistant Asthma
20132017PhD (Immunology & Microbiol)Co-SupervisorRole of TLR/IL-13/STAT6/PI3K Response in Early-life Respiratory Infection and Infection-Induced Chronic Lung Disease
20132017PhD (Immunology & Microbiol)Co-SupervisorInvestigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
20112015PhD (Immunology & Microbiol)Co-SupervisorIdentifying the Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
20112015PhD (Immunology & Microbiol)Co-SupervisorMechanisms of Predisposition to Secondary Bacterial Pneumonia
20112015PhD (Immunology & Microbiol)Co-SupervisorThe Role of Interferon Epsilon in Protection Against Chlamydial Reproductive Tract Infections
20112015PhD (Immunology & Microbiol)Co-SupervisorThe Roles of Fibulin-1 in Airway Remodelling in Lung Diseases
20112015PhD (Immunology & Microbiol)Co-SupervisorImmunoregulatory Therapies for Inflammatory Diseases
20102015PhD (Immunology & Microbiol)Co-SupervisorIndentification of New Therapeutics in COPD/ Emphysema
20072011PhD (Immunology & Microbiol)Co-SupervisorInvestigation of the Mechanisms of Respiratory Infection- Induced Lung Disease

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Immunology & Microbiol)Co-SupervisorImmune Mechanisms that Underpin Early-Life Chlamydia Respiratory Infection-Induced Chronic Lung Disease
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Dr Jay Horvat

Work Phone(02) 40 420220
Fax(02) 40 420026
Email
PositionSenior Lecturer
Inflammation and infection-induced diseases research group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaImmunology and Microbiology
Office
Level 2, East Wing HMRI Building,
HMRI Building,
Other
URL:www.newcastle.edu.au/profile/jay-horvat