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Dr Jay Horvat

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Career Summary

Biography

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Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Immunology
  • Pharmaceutical Sciences
  • Pharmacology

Fields of Research

Code Description Percentage
060599 Microbiology not elsewhere classified 15
111499 Paediatrics and Reproductive Medicine not elsewhere classified 15
110799 Immunology not elsewhere classified 70

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (32 outputs)

Year Citation Altmetrics Link
2015 Zouikr I, Ahmed AF, Horvat JC, Beagley KW, Clifton VL, Ray A, et al., 'Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity', Brain, Behavior, and Immunity, 44 235-246 (2015)

The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful experiences during this sensitive period of develop... [more]

The immune and nociceptive systems are shaped during the neonatal period where they undergo fine-tuning and maturation. Painful experiences during this sensitive period of development are known to produce long-lasting effects on the immune and nociceptive responses. It is less clear, however, whether inflammatory pain responses are primed by neonatal exposure to mild immunological stimuli, such as with lipopolysaccharide (LPS). Here, we examine the impact of neonatal LPS exposure on inflammatory pain responses, peripheral and hippocampal interleukin-1ß (IL-1ß), as well as mast cell number and degranulation in preadolescent and adult rats. Wistar rats were injected with LPS (0.05 mg/kg IP, Salmonella enteritidis) or saline on postnatal days (PNDs) 3 and 5 and later subjected to the formalin test at PNDs 22 and 80-97. At both time-points, and one-hour after formalin injection, blood and hippocampus were collected for measuring circulating and central IL-1ß levels using ELISA and Western blot, respectively. Paw tissue was also isolated to assess mast cell number and degree of degranulation using Toluidine Blue staining. Behavioural analyses indicate that at PND 22, LPS-challenged rats displayed enhanced flinching (p<.01) and licking (p<.01) in response to formalin injection. At PNDs 80-97, LPS-challenged rats exhibited increased flinching (p<.05), an effect observed in males only. Furthermore, neonatal LPS exposure enhanced circulating IL-1ß and mast cell degranulation in preadolescent but not adult rats following formalin injection. Hippocampal IL-1ß levels were increased in LPS-treated adult but not preadolescent rats in response to formalin injection. These data suggest neonatal LPS exposure produces developmentally regulated changes in formalin-induced behavioural responses, peripheral and central IL-1ß levels, as well as mast cell degranulation following noxious stimulation later in life. These findings highlight the importance of immune activation during the neonatal period in shaping immune response and pain sensitivity later in life. This is of clinical relevance given the high prevalence of bacterial infection during the neonatal period, particularly in the vulnerable population of preterm infants admitted to neonatal intensive care units.

DOI 10.1016/j.bbi.2014.10.014
Citations Scopus - 1
Co-authors Rick Thorne, Philip Hansbro, Deborah Hodgson
2015 Essilfie A-T, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', THORAX, 70 458-U151 (2015)
DOI 10.1136/thoraxjnl-2014-206067
Citations Web of Science - 1
Co-authors Philip Hansbro, Jodie Simpson, Paul Foster, Peter Gibson, Malcolm Starkey
2015 Singanayagam A, Glanville N, Walton RP, Aniscenko J, Pearson RM, Pinkerton JW, et al., 'A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.', Clin Sci (Lond), 129 245-258 (2015)
DOI 10.1042/CS20140654
Co-authors Philip Hansbro, Nathan Bartlett
2014 Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, et al., 'Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.', Mucosal Immunol, 7 478-488 (2014) [C1]
DOI 10.1038/mi.2013.65
Citations Scopus - 1
Co-authors Malcolm Starkey, Philip Hansbro, Joerg Mattes, Paul Foster
2014 O'Reilly M, Hansbro PM, Horvat JC, Beckett EL, Harding R, Sozo F, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', Anatomical Record, 297 758-769 (2014) [C1]

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces ... [more]

Preterm infants who receive supplemental oxygen for prolonged periods are at increased risk of impaired lung function later in life. This suggests that neonatal hyperoxia induces persistent changes in small conducting airways (bronchioles). Although the effects of neonatal hyperoxia on alveolarization are well documented, little is known about its effects on developing bronchioles. We hypothesized that neonatal hyperoxia would remodel the bronchiolar walls, contributing to altered lung function in adulthood. We studied three groups of mice (C57BL/6J) to postnatal day 56 (P56; adulthood) when they either underwent lung function testing or necropsy for histological analysis of the bronchiolar wall. One group inhaled 65% O2 from birth until P7, after which they breathed room air; this group experienced growth restriction (HE+GR group). We also used a group in which hyperoxia-induced GR was prevented by dam rotation (HE group). A control group inhaled room air from birth. At P56, the bronchiolar epithelium of HE mice contained fewer Clara cells and more ciliated cells, and the bronchiolar wall contained ~25% less collagen than controls; in HE+GR mice the bronchiolar walls had ~13% more collagen than controls. Male HE and HE+GR mice had significantly thicker bronchiolar epithelium than control males and altered lung function (HE males: greater dynamic compliance; HE+GR males: lower dynamic compliance). We conclude that neonatal hyperoxia remodels the bronchiolar wall and, in adult males, affects lung function, but effects are altered by concomitant growth restriction. Our findings may partly explain the reports of poor lung function in ex-preterm children and adults. Anat Rec, 297:758-769, 2014. © 2014 Wiley Periodicals, Inc.

DOI 10.1002/ar.22867
Citations Web of Science - 1
Co-authors Philip Hansbro
2014 O'Reilly M, Harding R, Sozo F, Hansbro PM, Horvat JC, Beckett EL, 'Bronchiolar Remodeling in Adult Mice Following Neonatal Exposure to Hyperoxia: Relation to Growth', Anatomical Record, 297 758-769 (2014)
DOI 10.1002/ar.22867
Co-authors Philip Hansbro
2014 Hansbro PM, Starkey MR, Mattes J, Horvat JC, 'Pulmonary immunity during respiratory infections in early life and the development of severe asthma', Annals of the American Thoracic Society, 11 S297-S302 (2014) [C1]

Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation... [more]

Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) to normally innocuous antigens. Combination therapies with inhaled corticosteroids and bronchodilators effectively manage mild to moderate asthma, but there are no cures, and patients with severe asthma do not respond to these treatments. The inception of asthma is linked to respiratory viral (respiratory syncytial virus, rhinovirus) and bacterial (Chlamydia, Mycoplasma) infections. The examination of mouse models of early-life infections and allergic airway disease (AAD) provides valuable insights into the mechanisms of disease inception that may lead to the development of more effective therapeutics. For example, early-life, but not adult, Chlamydia respiratory infections in mice permanently modify immunity and lung physiology. This increases the severity of AAD by promoting IL-13 expression, mucus hypersecretion, and AHR. We have identified novel roles for tumor necrosis factor-related apoptosisinducing ligand (TRAIL) and IL-13 in promoting infection-induced pathology in early life and subsequent chronic lung disease. Genetic deletion of TRAIL or IL-13 variously protected against neonatal infection-induced inflammation, mucus hypersecretion, altered lung structure, AHR, and impaired lung function. Therapeutic neutralization of these factors prevented infection-induced severe AAD. Other novel mechanisms and avenues for intervention are also being explored. Such studies indicate the immunological mechanisms that may underpin the association between early-life respiratory infections and the development of more severe asthma and may facilitate the development of tailored preventions and treatments.

DOI 10.1513/AnnalsATS.201402-086AW
Citations Scopus - 1
Co-authors Joerg Mattes, Philip Hansbro, Malcolm Starkey
2013 Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S, 'Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.', Front Immunol, 4 272 (2013) [C1]
DOI 10.3389/fimmu.2013.00272
Citations Scopus - 7Web of Science - 4
Co-authors Simon Keely
2013 Starkey MR, Nguyen DH, Kim RY, Nair PM, Brown AC, Essifie A-T, et al., 'Programming of the Lung in Early Life by Bacterial Infections Predisposes to Chronic Respiratory Disease', CLINICAL OBSTETRICS AND GYNECOLOGY, 56 566-576 (2013) [C1]
DOI 10.1097/GRF.0b013e3182993a0c
Citations Scopus - 3Web of Science - 1
Co-authors Malcolm Starkey, Philip Hansbro
2013 Fung KY, Mangan NE, Cumming H, Horvat JC, Mayall JR, Stifter SA, et al., 'Interferon-epsilon Protects the Female Reproductive Tract from Viral and Bacterial Infection', SCIENCE, 339 1088-1092 (2013) [C1]
DOI 10.1126/science.1233321
Citations Scopus - 29Web of Science - 35
Co-authors Philip Hansbro
2013 Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
Citations Scopus - 29Web of Science - 33
Co-authors Nicole Hansbro, Paul Foster, Ming Yang, Philip Hansbro, Simon Keely, Peter Wark
2013 Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
Citations Scopus - 18Web of Science - 13
Co-authors Ming Yang, Malcolm Starkey, Paul Foster, Philip Hansbro
2013 Starkey MR, Jarnicki AG, Essilfie A-T, Gellatly SL, Kim RY, Brown AC, et al., 'Murine models of infectious exacerbations of airway inflammation', CURRENT OPINION IN PHARMACOLOGY, 13 337-344 (2013) [C1]
DOI 10.1016/j.coph.2013.03.005
Citations Scopus - 6Web of Science - 7
Co-authors Paul Foster, Philip Hansbro, Malcolm Starkey
2013 Starkey MR, Essilfie A-T, Horvat JC, Kim RY, Nguyen DH, Beagley KW, et al., 'Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease', Mucosal Immunology, 6 569-579 (2013) [C1]
Citations Scopus - 8Web of Science - 4
Co-authors Paul Foster, Joerg Mattes, Philip Hansbro, Malcolm Starkey
2012 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors', Developmental Psychobiology, 54 568-575 (2012) [C1]
Citations Scopus - 1Web of Science - 1
Co-authors Vicki Clifton, Deborah Hodgson, Philip Hansbro, Roger Smith, Olivia Wynne
2012 Beckett EL, Phipps S, Starkey MR, Horvat JC, Beagley KW, Foster PS, Hansbro PM, 'TLR2, but not TLR4, is required for effective host defence against chlamydia respiratory tract infection in early life', PLOS One, 7 e39460 (2012) [C1]
Citations Scopus - 17Web of Science - 16
Co-authors Malcolm Starkey, Philip Hansbro, Paul Foster
2012 Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie A-T, et al., 'Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice', PLoS One, 7 e42588 (2012) [C1]
Citations Scopus - 7Web of Science - 6
Co-authors Joerg Mattes, Philip Hansbro, Malcolm Starkey
2012 Hansbro PM, Starkey MR, Kim RY, Stevens RL, Foster PS, Horvat JC, 'Programming of the lung by early-life infection', Journal of Developmental Origins of Health and Disease, 3 153-158 (2012) [C1]
Citations Scopus - 4Web of Science - 4
Co-authors Paul Foster, Philip Hansbro, Malcolm Starkey
2011 Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authors Margaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson, Paul Foster
2011 Asquith KL, Horvat JC, Kaiko GE, Carey AJ, Beagley KW, Hansbro PM, Foster PS, 'Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts', PLoS Pathogens, 7 e1001339 (2011) [C1]
Citations Scopus - 24Web of Science - 20
Co-authors Philip Hansbro, Paul Foster
2011 Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
DOI 10.1016/j.bbi.2011.03.014
Citations Scopus - 3Web of Science - 3
Co-authors Vicki Clifton, Olivia Wynne, Linkooi Ong, Deborah Hodgson, Roger Smith, Philip Hansbro
2011 Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, et al., 'Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells', European Respiratory Journal, 37 53-64 (2011) [C1]
DOI 10.1183/09031936.00049510
Citations Scopus - 31Web of Science - 29
Co-authors Paul Foster, Peter Gibson, Malcolm Starkey, Philip Hansbro
2011 Wynne OL, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner', Stress-the International Journal on the Biology of Stress, 14 247-261 (2011) [C1]
DOI 10.3109/10253890.2010.532576
Citations Scopus - 9Web of Science - 9
Co-authors Roger Smith, Philip Hansbro, Vicki Clifton, Deborah Hodgson, Olivia Wynne
2010 Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, et al., 'Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease', Journal of Immunology, 184 4159-4169 (2010) [C1]
DOI 10.4049/jimmunol.0902287
Citations Scopus - 41Web of Science - 35
Co-authors Philip Hansbro, Peter Gibson, Paul Foster, Malcolm Starkey
2010 Horvat JC, Starkey MR, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Allergy and Clinical Immunology, 125 617-625 (2010) [C1]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Paul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2010 Starkey MR, Horvat JC, Kim RY, Hansbro PM, 'Reply', Journal of Allergy and Clinical Immunology, 125 1415 (2010) [C3]
DOI 10.1016/j.jaci.2010.03.033
Co-authors Philip Hansbro, Malcolm Starkey
2008 Kaiko GE, Horvat JC, Beagley KW, Hansbro PM, 'Immunological decision-making: How does the immune system decide to mount a helper T-cell response?', Immunology, 123 326-338 (2008) [C1]
DOI 10.1111/j.1365-2567.2007.02719.x
Citations Scopus - 126Web of Science - 116
Co-authors Philip Hansbro
2008 Hansbro NG, Horvat JC, Wark PA, Hansbro PM, 'Understanding the mechanisms of viral induced asthma: New therapeutic directions', Pharmacology & Therapeutics, 117 313-353 (2008) [C1]
DOI 10.1016/j.pharmthera.2007.11.002
Citations Scopus - 57Web of Science - 50
Co-authors Philip Hansbro, Peter Wark, Nicole Hansbro
2007 Horvat JC, Beagley KW, Wade MA, Preston JA, Hansbro NG, Hickey DK, et al., 'Neonatal chlamydial infection induces mixed T-cell responses that drive allergic airway disease', American Journal of Respiratory and Critical Care Medicine, 176 556-564 (2007) [C1]
DOI 10.1164/rccm.200607-1005OC
Citations Scopus - 45Web of Science - 44
Co-authors Nicole Hansbro, Peter Gibson, Paul Foster, Philip Hansbro
2007 Preston JA, Essilfie AT, Horvat JC, Wade MA, Beagley KW, Gibson PG, et al., 'Inhibition of allergic airways disease by immunomodulatory therapy with whole killed Streptococcus pneumoniae', Vaccine, 25 8154-8162 (2007) [C1]
DOI 10.1016/j.vaccine.2007.09.034
Citations Scopus - 28Web of Science - 27
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2006 Skelding KA, Hickey DK, Horvat JC, Bao SS, Roberts KG, Read JM, et al., 'Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection', Vaccine, 24 355-366 (2006) [C1]
DOI 10.1016/j.vaccine.2005.07.104
Citations Scopus - 28Web of Science - 26
Co-authors Kathryn Skelding, Philip Hansbro
2004 Hansbro PM, Beagley KW, Horvat JC, Gibson PG, 'Role of atypical bacterial infection of the lung in predisposition/protection of asthma', Pharmacology and Therapeutics, 101 193-210 (2004) [C1]
DOI 10.1016/j.pharmthera.2003.10.007
Citations Scopus - 63Web of Science - 54
Co-authors Philip Hansbro, Peter Gibson
Show 29 more journal articles

Conference (53 outputs)

Year Citation Altmetrics Link
2014 Goggins B, Minahan K, Marks E, Mateer S, Cardona J, Knight D, et al., 'Hypoxia inducible factor (HIF)-1 accelerates epithelial wound healing through integrin regulation', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Darryl Knight
2014 Cardona J, Marks E, Goggins B, Mateer S, Minahan K, Horvat J, Keely S, 'The role of antibiotics in the development of food allergy', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Simon Keely
2014 Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Simon Keely, Philip Hansbro, Steven Maltby
2014 Starkey M, Hanish I, Dua K, Nair P, Haw T, Hsu A, et al., 'Interleukin-13 predisposes mice to more severe influenza infection by suppressing interferon responses and activating microRNA-21/PI3K', CYTOKINE, Melbourne, AUSTRALIA (2014) [E3]
DOI 10.1016/j.cyto2014.07.182
Co-authors Peter Wark, Malcolm Starkey, Philip Hansbro, Darryl Knight, Alan Hsu, Paul Foster
2014 Horvat J, Kim R, Mayall J, Pinkerton J, Starkey M, Essilfie A, et al., 'ANTIOXIDANT-BASED THERAPY FOR THE SUPPRESSION OF EARLY- LIFE INFECTION-INDUCED SEVERE ASTHMA', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_2
Co-authors Malcolm Starkey, Philip Hansbro, Lisa Wood
2013 Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Co-authors Philip Hansbro, Ming Yang, Nicole Hansbro, Simon Keely, Paul Foster, Peter Wark
2013 Hansbro P, Horvat J, Essilfie A-T, Kim R, Mayall J, Starkey M, Foster P, 'Macrolides suppress key features of experimental steroid-sensitive and steroid-resistant asthma', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Co-authors Malcolm Starkey, Paul Foster, Philip Hansbro
2013 Kim RY, Horvat JC, Starkey MR, Essilfie A-T, Foster PS, Hansbro PM, 'MICRORNA INHIBITION IN NEONATAL CHLAMYDIA LUNG INFECTION PREVENTS INFECTION-INDUCED LUNG PATHOLOGY IN LATER LIFE', RESPIROLOGY (2013) [E3]
Co-authors Paul Foster, Philip Hansbro, Malcolm Starkey
2013 Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'MACROLIDES SUPPRESS KEY FEATURES OF EXPERIMENTAL STEROID-SENSITIVE AND STEROID-RESISTANT ASTHMA', RESPIROLOGY (2013) [E3]
Citations Scopus - 1
Co-authors Peter Gibson, Philip Hansbro, Malcolm Starkey, Paul Foster
2012 Stifter SA, Fung K, Horvat JC, Hansbro PM, De Weerd NA, Hertzog PJ, 'Expression, purification and biological characterisation of a novel type I interferon, IFN epsilon', Immunology, Glasgow, Scotland (2012) [E3]
Co-authors Philip Hansbro
2012 Horvat JC, Essilfie A-T, Kim RY, Mayall JR, Starkey MR, Beckett EL, et al., 'Efficacy of antibiotic-based therapeutic strategies for the treatment of infection-induced, steroid-resistant allergic airways disease', Respirology, Canberra, ACT (2012) [E3]
Co-authors Philip Hansbro, Paul Foster, Malcolm Starkey
2012 Starkey MR, Kim RY, Horvat JC, Essilfie A-T, Beagley KW, Mattes J, et al., 'Constitutive IL-13 promotes respiratory chlamydial infection-induced chronic airway hyperresponsiveness', Respirology, Canberra, ACT (2012) [E3]
Co-authors Philip Hansbro, Malcolm Starkey, Joerg Mattes, Paul Foster
2011 O'Reilly M, Hansbro PM, Horvat JC, Sozo F, Harding R, 'Inhalation of hyperoxic gas in the neonatal period has long-term effects on the pulmonary airways', Journal of Developmental Origins of Health and Disease, Portland, Oregon (2011) [E3]
Co-authors Philip Hansbro
2011 Wynnea O, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Sex differences in the effect of neonatal infection and adult re-infection on hippocampal corticosterone receptors and stress response outcomes', Brain, Behavior, and Immunity, Chicago, Illinois (2011) [E3]
Co-authors Deborah Hodgson, Philip Hansbro, Roger Smith, Linkooi Ong
2011 Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson, Paul Foster
2011 Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Jodie Simpson, Paul Foster, Peter Gibson
2010 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Citations Scopus - 39Web of Science - 35
Co-authors Margaret Dunkley, Jodie Simpson, Peter Gibson, Paul Foster, Philip Hansbro
2010 O'Reilly M, Harding R, Beckett EL, Horvat JC, Hansbro PM, Sozo F, 'Exposure of the immature mouse lung to hyperoxic gas: do structural changes in the lung cause long-term changes in lung function?', 24th Fetal and Neonatal Physiology Workshop of Australia and New Zealand. Program and Abstracts, Wellington, NZ (2010) [E3]
Co-authors Philip Hansbro
2010 Fung K, Cumming H, Mangan N, Horvat JC, Hansbro PM, Hertzog P, 'Interferon epsilon regulates reproductive tract immunity to Chlamydia infection', Journal of Reproductive Immunology, Palm Cove, QLD (2010) [E3]
Co-authors Philip Hansbro
2009 Hansbro PM, Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Foster PS, 'Early life chlamydial infection enhances allergic airways disease through age-dependent differences in immunopathology', Journal of Immunology, Seattle, WASH. (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Co-authors Paul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009 Horvat JC, Starkey MR, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Chlamydial respiratory infection predisposes to neutrophil dominated allergic airways disease (AAD)', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authors Paul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009 Fung KY, Cumming H, Mangan N, Stifter S, Horvat JC, Hansbro PM, Hertzog PJ, 'Characterisation of a novel, constitutive cytokine that regulates mucosal immunity in the reproductive tract', Cytokine, Lisbon, Portugal (2009) [E3]
DOI 10.1016/j.cyto.2009.07.324
Co-authors Philip Hansbro
2009 Horvat JC, Starkey MR, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease (AAD)', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Paul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2009 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Respirology, Darwin, NT (2009) [E3]
DOI 10.1016/j.jaci.2009.10.018
Citations Scopus - 46Web of Science - 46
Co-authors Paul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor, mineralocorticoid receptor and corticotrophin releasing hormone mRNA abundance', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Roger Smith, Philip Hansbro, Deborah Hodgson, Olivia Wynne, Vicki Clifton
2008 Hansbro PM, Horvat JC, Beagley KW, Gibson PG, Foster PS, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authors Paul Foster, Philip Hansbro, Peter Gibson
2008 Horvat JC, Beagley KW, Gibson PG, Foster PS, Hansbro PM, 'Neutrophil influx during chlamydial lung infection determines the phenotype of allergic airways disease', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2008 Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Paul Foster, Margaret Dunkley, Philip Hansbro, Jodie Simpson, Peter Gibson
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor and mineralocorticoid receptor abundance', 15th Annual Meeting of the Psychoneuroimmunology Research Society: Program, Madison, WISC (2008) [E3]
Co-authors Olivia Wynne, Philip Hansbro, Roger Smith, Vicki Clifton, Deborah Hodgson
2008 Starkey MR, Horvat JC, Kim RY, Phipps S, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authors Peter Gibson, Philip Hansbro, Malcolm Starkey, Paul Foster
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Development of allergic airways disease (AAD) is differentially affected by the timing of chlamydial infection relative to allergic sensitization', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authors Paul Foster, Philip Hansbro, Peter Gibson
2007 Horvat JC, Garside CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Development of allergic airways disease is differentially affected by chlamydial respiratory infection at different ages', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]
Co-authors Paul Foster, Peter Gibson, Nicole Hansbro, Philip Hansbro
2007 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal corticosterone receptor abundance and circulating corticosterone', Early Human Development, Perth (2007) [E3]
Co-authors Vicki Clifton, Olivia Wynne, Roger Smith, Deborah Hodgson, Philip Hansbro
2007 Wynne OL, Horvat JC, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of postnatal stress on neuroendocrine development and function in adulthood in the mouse', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts, Melbourne, VIC (2007) [E3]
Co-authors Vicki Clifton, Deborah Hodgson, Olivia Wynne, Philip Hansbro
2007 Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Peter Gibson, Paul Foster, Jodie Simpson
2007 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'Allergic airways disease (AAD) is differentially affected by chlamydial lung infection at different stages of life', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Paul Foster, Philip Hansbro, Peter Gibson, Nicole Hansbro
2007 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Timing of chlamydial infection relative to allergen exposure differentially affects allergic airways disease', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authors Peter Gibson, Philip Hansbro, Paul Foster
2006 Horvat JC, Preston JA, Gibson PG, Beagley KW, Foster PS, Hansbro PM, 'Exacerbation of Allergic Airways Disease (AAD) by Chlamydia is Differentially Affected by the Timing of Infection Relative to Allergen Exposure', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authors Peter Gibson, Philip Hansbro, Paul Foster
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Streptococcus pneumoniae (SPN) lung infection suppresses hallmark features of a mouse model of asthma', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2006 Horvat JC, Moller CG, Wade MA, Preston JA, Hansbro NG, Gibson PG, et al., 'The development of allergic airways disease (AAD) is differently affected by chlamydial lung infection at different stages of life', Immunology and Cell Biology, Auckland, NZ (2006) [E3]
Co-authors Nicole Hansbro, Philip Hansbro, Peter Gibson, Paul Foster
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Early life chlamydial lung infection enhances allergic airways disease (AAD)', Respirology, Canberra (2006) [E3]
Co-authors Paul Foster, Peter Gibson, Nicole Hansbro, Philip Hansbro
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory streptococcus pneumoniae infection', Respirology, Canberra (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2006 Horvat JC, Wade MA, Preston JA, Hansbro NG, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection exacerbates allergic airways disease', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authors Philip Hansbro, Nicole Hansbro, Paul Foster, Peter Gibson
2006 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', Abstracts ATS 2006 International Conference, San Diego, California (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Inhibition of allergic lung disease by respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2006 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'The influence of allergic airways disease on the immune response to respiratory Streptococcus pneumoniae infection', 5th International Symposium on Pneumococci and Pneumococcal Diseases, Alice Springs (2006) [E3]
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2005 Preston JA, Horvat JC, Wade MA, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory streptococcus pneumoniae infection decreases key inflammatory responses in a mouse model of asthma', TISSUE ANTIGENS, Melbourne, AUSTRALIA (2005)
Co-authors Philip Hansbro, Peter Gibson, Paul Foster
2005 Horvat JC, Wade MA, Preston JA, Newcombe N, Ferguson AL, Kaiko G, et al., 'Neonatal But Not Adult Chlamydial Infection Induces the Development of Allergic Airways Disease Through Novel Mechanisms Involving Inflammation of Mixed Phenotype', Tissue Antigens, Melbourne, Australia (2005) [E3]
Citations Web of Science - 1
Co-authors Paul Foster, Peter Gibson, Philip Hansbro
2005 Horvat JC, Preston JA, Hansbro NG, Ferguson AL, Gibson PG, Beagley KW, et al., 'Neonatal chlamydial infection inhibits the development of allergic airway inflammation in adult mice', Inflammation Research, Melbourne, Australia (2005) [E3]
Co-authors Nicole Hansbro, Peter Gibson, Paul Foster, Philip Hansbro
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Timing of Streptococcus Pneumoniae (pnc) infection determines the magnitute of the effect on allergic airways inflammation (AAI) in a mouse model of asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authors Peter Gibson, Paul Foster, Philip Hansbro
2005 Preston JA, Horvat JC, Beagley KW, Foster PS, Gibson PG, Hansbro PM, 'Respiratory Streptococcus Pneumoniae Infection Decreases Eosinophilia and Mucus Cell Hyperplasia in a Mouse Model of Asthma', Respirology, Perth Convention Exhibition Centre (2005) [E3]
Co-authors Paul Foster, Philip Hansbro, Peter Gibson
2005 Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Combined transcutaneous and intranasal immunisation protects against genital tract Chlamydial infection', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts, USA. (2005) [E3]
Co-authors Philip Hansbro, Kathryn Skelding
2005 Skelding KA, Hickey DK, Horvat JC, Hansbro PM, Bao S, Beagley KW, 'Comparison of intranasal and transcutaneous immunisation for the protection against Chlamydial pneumonia', Proceedings of the Twelfth International Congress of Mucosal Immunology, Boston, Massachusetts (2005) [E3]
Co-authors Kathryn Skelding, Philip Hansbro
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Grants and Funding

Summary

Number of grants 20
Total funding $1,420,658

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $20,000

Investigation of the progression of Alzheimers Disease: Identification of potential drivers of disease$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Associate Professor Liz Milward, Professor Phil Hansbro, Dr Daniel Johnstone
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500589
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20144 grants / $823,091

Interferon epsilon for Chlamydia RTIs $729,817

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Doctor Jay Horvat, Professor Paul Hertzog
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1300071
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

The role of the microbiome in the development of food allergy$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Simon Keely, Doctor Jay Horvat
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301344
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Adelaide AUS, 4-9 April 2014$1,600

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400305
Type Of Funding Internal
Category INTE
UON Y

20134 grants / $392,942

Elucidating the mechanisms of infection-induced, steroid-resistant asthma$336,057

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Jay Horvat
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1200073
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Thoracic Society of Australia & New Zealand ASM, Darwin Convention Centre, 22 - 27 March 2013$1,885

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300883
Type Of Funding Internal
Category INTE
UON Y

20123 grants / $66,500

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100975
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Elucidating the mechanisms of steroid-resistant asthma$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200190
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Thoracic Society of Australia and New Zealand, Canberra, 31 March - 4 April 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200427
Type Of Funding Internal
Category INTE
UON Y

20113 grants / $61,625

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100037
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Antioxidant therapies for suppressing infection-induced asthma in children$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat, Associate Professor Lisa Wood, Professor Phil Hansbro
Scheme Youth Research Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1001002
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Thoracic Society of Australia & New Zealand ASM 2011, Perth Convention & Exhibition Centre, Perth WA, 2-4 April 2011$1,625

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100399
Type Of Funding Internal
Category INTE
UON Y

20101 grants / $25,000

Improved Treatment Strategies for Infection-Induced Neutrophilic Asthma$25,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Jay Horvat
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0900078
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20093 grants / $26,500

Immunisation against chlamydia-associated asthma$20,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Laureate Professor Paul Foster
Scheme Research Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189629
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jay Horvat
Scheme PULSE Education Prize
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189892
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

American Association of Immunologists and American Thoracic Society, Seattle USA, 8-21 May 2009$2,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Jay Horvat
Scheme Travel Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0190127
Type Of Funding Internal
Category INTE
UON Y

20041 grants / $5,000

Modulation of asthma by chlamydial infection at different ages$5,000

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Jay Horvat, Professor Phil Hansbro, Conjoint Professor Kenneth Beagley
Scheme PhD Scholarships
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183717
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2015 Fatty Acids and Bronchodilator Responses
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015 Neuropathological Effects of Putative Modifiers of Alzheimer's Disease Risk and Progression: Investigation in Mouse Models
Health, Faculty of Health and Medicine
Co-Supervisor
2015 Contribution of Cell Death to the Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015 Investigation of Novel Immune Molecules in the Pathogenesis of Female Chlamydia Genital Tract Infections
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2015 To assess the role of IFNe in modulating innate immune responses and protecting against Chlamydia infection in human tissues
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014 Hypoxia Inducible Factor (HIF)-1 mediates epithelial wound healing through integrin regulation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014 Effect of Iron loading on vision in a mouse model of haemochromatosis
Health, Faculty of Health and Medicine
Co-Supervisor
2014 Investigating the Inter-Relationship between Iron Homeostasis and Infection in the Pathogenesis of Disease
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2013 Role of TLR/IL-13/STAT6/PI3K Response in Early-life Respiratory Infection and Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2013 Elucidating the Mechanisms of Infection-Induced, Steroid-Resistant Asthma
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2013 Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011 The Role of Interferon Epsilon in Protection Against Chlamydial Reproductive Tract Infections
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011 Mechanisms of Predisposition to Secondary Bacterial Pneumonia
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011 Immunoregulatory Therapies for Inflammatory Diseases
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011 The Roles of Fibulin-1 in Airway Remodelling in Lung Diseases
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2011 Identifying the Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2010 Indentification of New Therapeutics in COPD/ Emphysema
Microbiology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2015 Investigation of the Mechanisms of Respiratory Infection- Induced Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2014 Immune Mechanisms that Underpin Early-Life Chlamydia Respiratory Infection-Induced Chronic Lung Disease
Microbiology, Faculty of Health and Medicine
Co-Supervisor
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News

HMRI logo

Newcastle researchers help in fight against STDs

March 1, 2013

Newcastle researchers have contributed to the discovery of a protein in the female reproductive tract that protects against sexually transmitted diseases (STDs) such as chlamydia and herpes simplex virus (HSV).

Dr Jay Horvat

Position

Senior Lecturer
Inflammation and infection-induced diseases research group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Email jay.horvat@newcastle.edu.au
Phone (02) 40 420220
Fax (02) 40 420026

Office

Room Level 2, East Wing HMRI Building
Building HMRI Building
Location Other

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