Dr Guy Cameron
Indigenous Imaging Fellow
School of Psychological Sciences
- Email:guy.cameron@newcastle.edu.au
- Phone:(02) 4913 8070
Career Summary
Biography
I'm a proud Aboriginal man; my mob are the Wailwan people, I have strong family connection with Wongaibon and Dainggatti. I'm an early career researcher (ECR) investigating fundamentals of immunology and microbiology in various tissues and disease states. My initial laboratory research focused on understanding the role of immune pathways in the development of respiratory disease, such as asthma and COPD, using pre-clinical models. This work led to several co-authored publications in top journals in the field for respiratory, allergy and immunology research. This earlier work inspired my PhD in Immunology and Microbiology where I examined similar immune pathways using pre-clinical models of the urinary tract insult, such as sterile acute kidney injury and ascending bacterial urinary tract infection.
Since graduating from PhD studies, I have joined Professor Kelvin Kong’s research team, based at the Hunter Medical Research Institute (HMRI). Here I started investigating the biological properties of the bacterial species, Alloiococcus otitidis, which has a become a significant factor in the contemporary understanding of chronic ear infections. A further area of skill development has been conduction of a health audit with HMRI colleagues to gain a thorough understanding of respiratory admissions and Emergency Department presentations at hospitals across the Hunter New England Local Health District (HNELHD), based on the ICD-10 hospital codes. I also hold a fellowship supervised by Professor Michael Breakspear which is co-funded by the national imaging facility and systems neuroscience group to foster Indigenous collaboration and ownership in the field of imaging research to improve the health and wellbeing of Indigenous Australians.
In addition to my research activities, I take my heritage as an Aboriginal researcher seriously. As Chair of the Indigenous Student Engagement Committee, I seek opportunities to promote educational opportunities for upcoming Indigenous scholars. This includes tutoring and lecturing at the University of Newcastle and maintaining strong links to the team at the Wollotuka Institute, supporting for Indigenous activities. Additionally, I am a member of the Animal Care and Ethics Committee.
Vision
I aim to be able to utilise both basic and clinical expertise in the future to assemble a multi-disciplinary team to tackle major health challenges, specifically for Aboriginal and Torres Strait Islander people. Although early in my career, I have a strong commitment to improving healthcare using a biomedical, clinical and community driven approach.
Qualifications
- Doctor of Philosophy in Immunology and Microbiology, University of Newcastle
- Bachelor of Biomedical Sciences (Hons), University of Newcastle
Keywords
- Immunology
- Microbiology
Languages
- English (Mother)
Fields of Research
Code | Description | Percentage |
---|---|---|
450402 | Aboriginal and Torres Strait Islander biomedical and clinical sciences | 40 |
320402 | Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) | 60 |
Professional Experience
UON Appointment
Title | Organisation / Department |
---|---|
Casual Lecturer | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Microbiomic ECR Fellow | University of Newcastle School of Medicine and Public Health Australia |
Indigenous Imaging Fellow | University of Newcastle School of Psychological Sciences Australia |
Awards
Prize
Year | Award |
---|---|
2021 |
Indigenous STEM Professional Career Achievement Award from the CSIRO and BHP Foundation CSIRO - Commonwealth Scientific and Industrial Research Organisation |
Teaching
Code | Course | Role | Duration |
---|---|---|---|
INDH2490 |
Foundations of Aboriginal and Torres Strait Islander health College of Health, Medicine & Wellbeing - The University of Newcastle This course provides an opportunity for students to enhance their knowledge of historical and contemporary issues relevant to Aboriginal and Torres Strait Islander people. This course will explore the tenets of culturally capable and safe health practice and its development by exploring the dynamics between Australia's health practice and contemporary social and healthcare policies, and the current health status for Aboriginal and Torres Strait Islander peoples. |
Tutorial facilitator | 1/1/2022 - 31/12/2022 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (7 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2022 |
Tu X, Kim RY, Brown AC, de Jong E, Jones-Freeman B, Ali MK, et al., 'Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap', Journal of Allergy and Clinical Immunology, 150 817-829.e6 (2022) [C1] Background: Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COP... [more] Background: Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap (ACO). Patients characterized with ACO have increased disease severity; however, the mechanisms driving this have not been widely studied. Objectives: This study sought to characterize the phenotypic and transcriptomic features of experimental ACO in mice induced by chronic house dust mite antigen and cigarette smoke exposure. Methods: Female BALB/c mice were chronically exposed to house dust mite antigen for 11 weeks to induce experimental asthma, cigarette smoke for 8 weeks to induce experimental COPD, or both concurrently to induce experimental ACO. Lung inflammation, structural changes, and lung function were assessed. RNA-sequencing was performed on separated airway and parenchyma lung tissues to assess transcriptional changes. Validation of a novel upstream driver SPI1 in experimental ACO was assessed using the pharmacological SPI1 inhibitor, DB2313. Results: Experimental ACO recapitulated features of both asthma and COPD, with mixed pulmonary eosinophilic/neutrophilic inflammation, small airway collagen deposition, and increased airway hyperresponsiveness. Transcriptomic analysis identified common and distinct dysregulated gene clusters in airway and parenchyma samples in experimental asthma, COPD, and ACO. Upstream driver analysis revealed increased expression of the transcription factor Spi1. Pharmacological inhibition of SPI1 using DB2313, reduced airway remodeling and airway hyperresponsiveness in experimental ACO. Conclusions: A new experimental model of ACO featuring chronic dual exposures to house dust mite and cigarette smoke mimics key disease features observed in patients with ACO and revealed novel disease mechanisms, including upregulation of SPI1, that are amenable to therapy.
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Nova | |||||||||
2021 |
Loering S, Cameron GJM, Bhatt NP, Belz GT, Foster PS, Hansbro PM, Starkey MR, 'Differences in pulmonary group 2 innate lymphoid cells are dependent on mouse age, sex and strain', IMMUNOLOGY AND CELL BIOLOGY, 99 542-551 (2021) [C1]
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Nova | |||||||||
2019 |
Donovan C, Starkey MR, Kim RY, Rana BMJ, Barlow JL, Jones B, et al., 'Roles for T/B lymphocytes and ILC2s in experimental chronic obstructive pulmonary disease', Journal of Leukocyte Biology, 105 143-150 (2019) [C1] Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogen... [more] Pulmonary inflammation in chronic obstructive pulmonary disease (COPD) is characterized by both innate and adaptive immune responses; however, their specific roles in the pathogenesis of COPD are unclear. Therefore, we investigated the roles of T and B lymphocytes and group 2 innate lymphoid cells (ILC2s) in airway inflammation and remodelling, and lung function in an experimental model of COPD using mice that specifically lack these cells (Rag1 -/- and Rora fl/fl Il7r Cre [ILC2-deficient] mice). Wild-type (WT) C57BL/6 mice, Rag1 -/- , and Rora fl/fl Il7r Cre mice were exposed to cigarette smoke (CS; 12 cigarettes twice a day, 5 days a week) for up to 12¿weeks, and airway inflammation, airway remodelling (collagen deposition and alveolar enlargement), and lung function were assessed. WT, Rag1 -/- , and ILC2-deficient mice exposed to CS had similar levels of airway inflammation and impaired lung function. CS exposure increased small airway collagen deposition in WT mice. Rag1 -/- normal air- and CS-exposed mice had significantly increased collagen deposition compared to similarly exposed WT mice, which was associated with increases in IL-33, IL-13, and ILC2 numbers. CS-exposed Rora fl/fl Il7r Cre mice were protected from emphysema, but had increased IL-33/IL-13 expression and collagen deposition compared to WT CS-exposed mice. T/B lymphocytes and ILC2s play roles in airway collagen deposition/fibrosis, but not inflammation, in experimental COPD.
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Nova | |||||||||
2019 |
Cameron GJM, Jiang SH, Loering S, Deshpande AV, Hansbro PM, Starkey MR, 'Emerging therapeutic potential of group 2 innate lymphoid cells in acute kidney injury', Journal of Pathology, 248 9-15 (2019) [C1] Acute kidney injury (AKI) remains a global challenge and, despite the availability of dialysis and transplantation, can be fatal. Those that survive an AKI are at increased risk o... [more] Acute kidney injury (AKI) remains a global challenge and, despite the availability of dialysis and transplantation, can be fatal. Those that survive an AKI are at increased risk of developing chronic kidney disease and end stage renal failure. Understanding the fundamental mechanisms underpinning the pathophysiology of AKI is critical for developing novel strategies for diagnosis and treatment. A growing body of evidence indicates that amplifying type 2 immunity may have therapeutic potential in kidney injury and disease. Of particular interest are the recently described subset of innate immune cells, termed group 2 innate lymphoid cells (ILCs). Group 2 ILCs are crucial tissue-resident immune cells that maintain homeostasis and regulate tissue repair at multiple organ sites, including the kidney. They are critical mediators of type 2 immune responses following infection and injury. The existing literature suggests that activation of group 2 ILCs and production of a local type 2 immune milieu is protective against renal injury and associated pathology. In this review, we describe the emerging role for group 2 ILCs in renal homeostasis and repair. We provide an in-depth discussion of the most recent literature that use preclinical models of AKI and assess the therapeutic effect of modulating group 2 ILC function. We debate the potential for targeting these cells as novel cellular therapies in AKI and discuss the implications for future studies and translation. Copyright © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Nova | |||||||||
2019 |
Starkey MR, Plank MW, Casolari P, Papi A, Pavlidis S, Guo Y, et al., 'IL-22 and its receptors are increased in human and experimental COPD and contribute to pathogenesis', EUROPEAN RESPIRATORY JOURNAL, 54 (2019) [C1]
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Nova | |||||||||
2019 |
Cameron GJM, Cautivo KM, Loering S, Jiang SH, Deshpande AV, Foster PS, et al., 'Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury', Frontiers in Immunology, 10 (2019) [C1]
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Nova | |||||||||
2019 |
Loering S, Cameron GJM, Starkey MR, Hansbro PM, 'Lung development and emerging roles for type 2 immunity', Journal of Pathology, 247 686-696 (2019) [C1] Lung development is a complex process mediated through the interaction of multiple cell types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues ... [more] Lung development is a complex process mediated through the interaction of multiple cell types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into early adulthood. The process can be separated into five different developmental stages: embryonic, pseudoglandular, canalicular, saccular, and alveolar. Whilst lung bud formation and branching morphogenesis have been studied extensively, the mechanisms of alveolarisation are incompletely understood. Aberrant lung development can lead to deleterious consequences for respiratory health such as bronchopulmonary dysplasia (BPD), a disease primarily affecting preterm neonates, which is characterised by increased pulmonary inflammation and disturbed alveolarisation. While the deleterious effects of type 1-mediated inflammatory responses on lung development have been well established, the role of type 2 responses in postnatal lung development remains poorly understood. Recent studies indicate that type 2-associated immune cells, such as group 2 innate lymphoid cells and alveolar macrophages, are increased in number during postnatal alveolarisation. Here, we present the current state of understanding of the postnatal stages of lung development and the key cell types and mediators known to be involved. We also provide an overview of how stem cells are involved in lung development and regeneration, and the negative influences of respiratory infections. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Nova | |||||||||
Show 4 more journal articles |
Grants and Funding
Summary
Number of grants | 12 |
---|---|
Total funding | $3,248,604 |
Click on a grant title below to expand the full details for that specific grant.
20242 grants / $601,305
From community priority to delivery of care: Co-designing effective treatment models for Aboriginal women with asthma during pregnancy$599,305
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Doctor Elissa Jane Elvidge, Karen Baker, Doctor Guy Cameron, Doctor Tameka McFadyen, Kim Morey, Louise Morris, Associate Professor Vanessa Murphy, Professor Peter O'Mara, Ms Shanthi Ramanathan, Associate Professor Geraint Rogers, Professor Juanita Sherwood, Doctor Meredith Tavener, Dr Steven Taylor, Ms Yeena Thompson, Professor Peter Wark |
Scheme | MRFF - PPHRI - Consumer-Led Research |
Role | Investigator |
Funding Start | 2024 |
Funding Finish | 2026 |
GNo | G2300814 |
Type Of Funding | C1300 - Aust Competitive - Medical Research Future Fund |
Category | 1300 |
UON | Y |
Indigenisation of the undergraduate curriculum in biomedical science, pharmacy and sport science: Consultation with Indigenous stakeholders$2,000
Funding body: Learning Design and Teaching Innovation | The University of Newcastle
Funding body | Learning Design and Teaching Innovation | The University of Newcastle |
---|---|
Project Team | Professor Karen Mate, Doctor Lizzie Manning, Doctor Guy Cameron, Doctor Sajie Endacott, Ms Sharleen Slater |
Scheme | Teaching and Learning Seed Funding |
Role | Investigator |
Funding Start | 2024 |
Funding Finish | 2024 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20234 grants / $2,527,629
A treatable traits framework for chronic respiratory disease in rural and regional Aboriginal communities$1,997,629
Funding body: Medical Research Futures Fund (MRFF)
Funding body | Medical Research Futures Fund (MRFF) |
---|---|
Project Team | Professor Geraint Rogers, Professor Peter Wark, Professor Jodie Simpson, Doctor Steven Taylor, Doctor Guy Cameron, Doctor Elissa Elvidge, Ms Erin Flynn, Professor Caroline Miller, Professor Steven Wesselingh, Mr Paul Duncan, A/Professor Odette Pearson, Ms Karen Baker, A/Professor Penny Reeves. |
Scheme | 2021 MRFF Chronic Respiratory Conditions |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2028 |
GNo | |
Type Of Funding | C1300 - Aust Competitive - Medical Research Future Fund |
Category | 1300 |
UON | N |
Genomic surveillance of bacterial strains causing ear disease and upper respiratory illnesses in Hunter New England children and young people$500,000
Funding body: NSW Ministry of Health
Funding body | NSW Ministry of Health |
---|---|
Project Team | Doctor Guy Cameron, Doctor Trent Butler, Professor Kelvin Kong, Doctor Hemalatha Varadhan, Ms Sharron Hall, Doctor Michael Zhang, Professor Joerg Mattes, Doctor Christopher Ashhurst-Smith, Ms Toni Manton, Mr Trumaine Rankmore, Dr Trent Butler |
Scheme | Early-Mid Career Researcher Grant |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2026 |
GNo | G2300019 |
Type Of Funding | C2400 – Aust StateTerritoryLocal – Other |
Category | 2400 |
UON | Y |
Seeds of growth and healing: Exploring the healing properties of Indigenous native plants$15,000
Funding body: The University of Newcastle and the University of Waikato
Funding body | The University of Newcastle and the University of Waikato |
---|---|
Project Team | Ms Jennifer Rumbel, Doctor Guy Cameron, Doctor Robert Chapman, Professor Michael Breakspear, A/Professor Saad Ramadan, Professor Hubert Hondermarck, Mr John Clarke; Doctor Mitchell Head, A/Professor Maui Hudson, Doctor Rogena Sterling, A/Professor Pawel Olszewski, Ms Katie-Lee Riddle |
Scheme | Partnership Seed Fund | The University of Newcastle and the University of Waikato |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Enhancing Indigenous cultural capability and student engagement in science and health through collaborative learning and animated videos$15,000
Funding body: The University of Newcastle and the University of Waikato
Funding body | The University of Newcastle and the University of Waikato |
---|---|
Project Team | Ms Josephine Smith, A/Professor Kathryn Skelding, A/Professor Karen Mate, Doctor Lizzie Manning, Doctor Guy Cameron, Mr Paul McDonald, Ms Andrea Windley, Doctor Joanna Hicks, Doctor Kim Hebert-Losier, Ms Nicole Pepperell, Doctor Kirsten Petrie, Ms Jessicca Usu, Doctor Gloria Hinemoa Clarke |
Scheme | Partnership Seed Fund | The University of Newcastle and the University of Waikato |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20222 grants / $15,670
Establishing laboratory methodology for Indigenous ear disease; Advanced studies of the role of Alloiococcus otitidis in Aboriginal and Torres Strait children with otitis media$10,000
Funding body: College of Health, Medicine and Wellbeing, University of Newcastle
Funding body | College of Health, Medicine and Wellbeing, University of Newcastle |
---|---|
Project Team | Doctor Guy Cameron, Doctor Christopher Ashhurst-Smith, Doctor Karl Hassan, Professor Kelvin Kong, Ms Sharron Hall |
Scheme | College of Health, Medicine and Wellbeing Strategic Research Pilot Grant round |
Role | Lead |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Audit of Hunter New England ear, nose & throat surgical interventions$5,670
Funding body: Immune Health Program, Hunter Medical Research Institute
Funding body | Immune Health Program, Hunter Medical Research Institute |
---|---|
Project Team | Doctor Guy Cameron, Professor Kelvin Kong, Ms Sharron Hall |
Scheme | Immune Health Program Small Grant scheme for HMRI Platform Support |
Role | Lead |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20181 grants / $98,000
Understanding the role of group 2 innate lymphoid cells and mucosal cytokines in urinary tract injury and infection$98,000
Funding body: Australian Government, Department of Education, Skills, and Employment
Funding body | Australian Government, Department of Education, Skills, and Employment |
---|---|
Project Team | Doctor Guy Cameron, Doctor Malcolm Starkey, Doctor Aniruddh Deshpande, Professor Philip Hansbro, A/Professor Adam Collison |
Scheme | Research Training Program |
Role | Lead |
Funding Start | 2018 |
Funding Finish | 2021 |
GNo | |
Type Of Funding | C1700 - Aust Competitive - Other |
Category | 1700 |
UON | N |
20171 grants / $2,000
Understanding the role of group 2 innate lymphoid cells in the kidney$2,000
Funding body: PRC GrowUpWell
Funding body | PRC GrowUpWell |
---|---|
Project Team | Doctor Guy Cameron, Doctor Malcolm Starkey, Doctor Aniruddh Deshpande, Professor Philip Hansbro |
Scheme | PRC GrowUpWell Honours Research Internship |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20161 grants / $2,000
Understanding how immune cells repair the kidney after acute kidney injury$2,000
Funding body: School of Biomedical Sciences and Pharmcy, The University of Newcastle
Funding body | School of Biomedical Sciences and Pharmcy, The University of Newcastle |
---|---|
Project Team | Doctor Guy Cameron, Doctor Malcolm Starkey, Doctor Aniruddh Deshpande |
Scheme | School of Biomedical Sciences and Pharmacy Vacation Scholarship |
Role | Lead |
Funding Start | 2016 |
Funding Finish | 2017 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20151 grants / $2,000
Transcriptome analysis of developing mouse lung following early life infection$2,000
Funding body: School of Biomedical Sciences and Pharmcy, The University of Newcastle
Funding body | School of Biomedical Sciences and Pharmcy, The University of Newcastle |
---|---|
Project Team | Doctor Guy Cameron, Doctor Malcolm Starkey, Professor Philip Hansbro |
Scheme | School of Biomedical Sciences and Pharmacy Vacation Scholarship |
Role | Lead |
Funding Start | 2015 |
Funding Finish | 2016 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Research Collaborations
The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.
Country | Count of Publications | |
---|---|---|
Australia | 7 | |
United Kingdom | 3 | |
Canada | 2 | |
United States | 2 | |
Italy | 1 |
News
News • 31 Jul 2023
$1m supports immunology and microbiology researchers
Two Newcastle scientists are among six promising researchers recognised with a prestigious NSW Government grant designed to support and build health and medical research talent in NSW.
Dr Guy Cameron
Positions
Indigenous Imaging Fellow
School of Psychological Sciences
College of Engineering, Science and Environment
Microbiomic ECR Fellow
School of Medicine and Public Health
College of Health, Medicine and Wellbeing
Casual Lecturer
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Contact Details
guy.cameron@newcastle.edu.au | |
Phone | (02) 4913 8070 |
Links |
Personal webpage |
Office
Building | HMRI building |
---|---|
Location | John Hunter Hospital campus , |