Ms Sharron Hall

Research Assistant

School of Medicine and Public Health (Immunology and Microbiology)

Career Summary

Biography

Research Expertise
Management of research projects relating to the immunology of the upper respiratory tract, particularly immune fucntion in elite athletes, infants at risk of sudden infant death and children with otitis media with effusion. Use of saliva for studies of mucosal immune function. Studies in the pathology of Aboriginal Health. Development of enzyme-linked immuno assays. Ethics and safety applications. training new staff.

Administrative Expertise
Management of research funds.

Qualifications

  • Bachelor of Science, University of Newcastle

Keywords

  • mucosal immunology

Fields of Research

Code Description Percentage
110799 Immunology not elsewhere classified 50
110899 Medical Microbiology not elsewhere classified 50

Professional Experience

Professional appointment

Dates Title Organisation / Department
1/01/1983 -  Hospital Scientist Hunter New England Health
Hunter Area Pathology Service, Immunology Department
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (20 outputs)

Year Citation Altmetrics Link
2015 Moscovis SM, Gordon AE, Al Madani OM, Gleeson M, Scott RJ, Hall ST, et al., 'Genetic and environmental factors affecting TNF-a responses in relation to sudden infant death syndrome', Frontiers in Immunology, 6 (2015)

Dysregulation of the inflammatory responses has been suggested to contribute to the events leading to sudden infant deaths. Our objectives were (1) to analyze a single nucleotide ... [more]

Dysregulation of the inflammatory responses has been suggested to contribute to the events leading to sudden infant deaths. Our objectives were (1) to analyze a single nucleotide polymorphism (SNP) associated with high levels of tumor necrosis factor-a (TNF-a) responses, TNF G-308A, in sudden infant death syndrome (SIDS) infants, SIDS and control parents, and ethnic groups with different incidences of SIDS; (2) the effects of two risk factors for SIDS, cigarette smoke and virus infection, on TNF-a responses; and (3) to assess effects of genotype, cigarette smoke, and gender on TNF-a responses to bacterial toxins identified in SIDS infants. TNF G-308A genotypes were determined by real-time polymerase chain reaction for SIDS infants from Australia, Germany, and Hungary; parents of SIDS infants and their controls; and populations with high (Aboriginal Australian), medium (Caucasian), and low (Bangladeshi) SIDS incidences. Leukocytes from Caucasian donors were stimulated in vitro with endotoxin or toxic shock syndrome toxin-1 (TSST-1). TNF-a responses were measured by L929 bioassay (IU/ml) and assessed in relation to genotype, smoking status, and gender. There was a significantly higher proportion of the minor allele AA genotype among Australian SIDS infants (6/24, 24%) compared to 3/62 (4.8%) controls (p = 0.03). There were no significant differences in TNF-a responses by TNF G-308A genotypes when assessed in relation to smoking status or gender. Given the rarity of the TNF G-308A A allele in Caucasian populations, the finding that 24% of the Australian SIDS infants tested had this genotype requires further investigation and cautious interpretation. Although non-smokers with the AA genotype had higher TNFa responses to both TSST-1 and endotoxin, there were too few subjects with this rare allele to obtain statistically valid results. No effects of genotype, smoking, or gender were observed for TNF-a responses to these toxins.

DOI 10.3389/fimmu.2015.00374
Co-authors Rodney Scott, Maree Gleeson
2015 Moscovis SM, Gordon AE, Al Madani OM, Gleeson M, Scott RJ, Hall ST, et al., 'Virus Infections and Sudden Death in Infancy: The Role of Interferon-¿.', Front Immunol, 6 107 (2015)
DOI 10.3389/fimmu.2015.00107
Citations Scopus - 1Web of Science - 1
Co-authors Maree Gleeson, Rodney Scott
2015 Burns C, Hall ST, Smith R, Blackwell C, 'Cytokine Levels in Late Pregnancy: Are Female Infants Better Protected Against Inflammation?', Front Immunol, 6 318 (2015)
DOI 10.3389/fimmu.2015.00318
Citations Scopus - 1Web of Science - 1
Co-authors Roger Smith
2015 Moscovis SM, Cox A, Hall ST, Burns CJ, Scott RJ, Blackwell CC, 'Effects of gender, cytokine gene polymorphisms and environmental factors on inflammatory responses.', Innate Immun, 21 523-530 (2015)
DOI 10.1177/1753425914553645
Citations Scopus - 1Web of Science - 1
Co-authors Rodney Scott
2014 Moscovis S, Hall S, Burns C, Scott R, Blackwell C, 'Development of an experimental model for assessing the effects of cigarette smoke and virus infections on inflammatory responses to bacterial antigens', Innate Immunity, 20 647-658 (2014) [C1]

Interactions among major risk factors associated with bacterial infections were assessed in a model system using surrogates for virus infection; IFN-g, and exposure to cigarette s... [more]

Interactions among major risk factors associated with bacterial infections were assessed in a model system using surrogates for virus infection; IFN-g, and exposure to cigarette smoke; cigarette smoke extract (CSE), nicotine and cotinine. Cytokine responses elicited by LPS from THP-1 cells in the presence of these components, or combinations of components, were assessed by multiplex bead assay, i.e. IL-1ß, IL-6, IL-8, IL-10, TNF-a and IFN-¿. IFN-¿-priming significantly increased pro-inflammatory cytokines induced by LPS. CSE suppressed production of pro-inflammatory cytokines IL-1ß, TNF-a and IFN-¿, but enhanced production of IL-8. Nicotine and cotinine suppressed all cytokine responses. In combination, IFN-¿ masked the inhibitory effects of CSE. In relation to the objectives of the study, we concluded that (a) IFN¿ at biologically relevant concentrations significantly enhanced pro-inflammatory responses; (b) CSE, nicotine and cotinine dysregulated the inflammatory response and that the effects of CSE were different from those of the individual components, nicotine and cotinine; (c) when both IFN-¿ and CSE were present, IFN-¿ masked the effect of CSE. There is a need for clinical investigations on the increase in IL-8 responses in relation to exposure to cigarette smoke and increased pro-inflammatory responses in relation to recent viral infection. © 2013 The Author(s).

DOI 10.1177/1753425913503893
Citations Scopus - 6Web of Science - 6
Co-authors Caroline Blackwell, Rodney Scott
2014 Moscovis SM, Hall ST, Burns CJ, Scott RJ, Blackwell CC, 'The male excess in sudden infant deaths', INNATE IMMUNITY, 20 24-29 (2014) [C1]
DOI 10.1177/1753425913481071
Citations Scopus - 8Web of Science - 7
Co-authors Caroline Blackwell, Rodney Scott
2014 Ashhurst-Smith C, Hall ST, Burns CJ, Stuart J, Blackwell CC, 'Induction of inflammatory responses from THP-1 cells by cell-free filtrates from clinical isolates of Alloiococcus otitidis', INNATE IMMUNITY, 20 283-289 (2014) [C1]
DOI 10.1177/1753425913490535
Co-authors Caroline Blackwell, John Stuart
2014 Ashhurst-Smith C, Hall ST, Burns CJ, Stuart J, Blackwell CC, 'Invitro inflammatory responses elicited by isolates of Alloiococcus otitidis obtained from children with otitis media with effusion', INNATE IMMUNITY, 20 320-326 (2014) [C1]
DOI 10.1177/1753425913492181
Citations Scopus - 1
Co-authors John Stuart, Caroline Blackwell
2013 Moscovis S, Hall S, Burns C, Scott R, Blackwell C, 'Development of an experimental model for assessing the effects of cigarette smoke and virus infections on inflammatory responses to bacterial antigens.', Innate Immun, 20 647-658 (2013) [C1]
DOI 10.1177/1753425913503893
Citations Scopus - 3Web of Science - 3
Co-authors Rodney Scott, Caroline Blackwell
2013 Titmarsh CJ, Moscovis SM, Hall S, Tzanakaki G, Kesanopoulos K, Xirogianni A, et al., 'Comparison of cytokine gene polymorphisms among Greek patients with invasive meningococcal disease or viral meningitis', JOURNAL OF MEDICAL MICROBIOLOGY, 62 694-700 (2013) [C1]
DOI 10.1099/jmm.0.058073-0
Citations Scopus - 2Web of Science - 3
Co-authors Rodney Scott, Caroline Blackwell
2012 Ashhurst-Smith CIJ, Hall ST, Stuart J, Burns CJ, Liet E, Walker PJ, et al., 'Alloiococcus otitidis: An emerging pathogen in otitis media', Journal of Infection, 64 233-235 (2012) [C1]
Citations Scopus - 5Web of Science - 4
Co-authors Caroline Blackwell, John Stuart
2007 Ashhurst-Smith CIJ, Hall ST, Walker PJ, Stuart JE, Hansbro PM, Blackwell CC, 'Isolation of Alloiococcus otitidis from Indigenous and non-Indigenous Australian children with chronic otitis media with effusion', FEMS Immunology and Medical Microbiology, 51 163-170 (2007) [C1]
DOI 10.1111/j.1574-695X.2007.00297.x
Citations Scopus - 20Web of Science - 17
Co-authors John Stuart, Philip Hansbro, Caroline Blackwell
2006 Moscovis SM, Gordon AE, Al Madani OM, Gleeson M, Scott R, Roberts-Thomson JM, et al., 'IL6 G-174C Associated With Sudden Infant Death Syndrome in a Caucasian Australian Cohort', Human Immunology, 67 819-825 (2006) [C1]
DOI 10.1016/j.humimm.2006.07.010
Citations Scopus - 32Web of Science - 31
Co-authors Caroline Blackwell, Rodney Scott, Maree Gleeson
2005 Blackwell CC, Moscovis SM, Gordon AE, Al Madani OM, Hall S, Gleeson M, et al., 'Cytokine responses and sudden infant death: genetic, developmental, and environmental risk factors', Journal of Leukocyte Biology, 78 1242-1254 (2005) [C1]
DOI 10.1189/jlb.0505253
Citations Scopus - 57Web of Science - 52
Co-authors Rodney Scott, Maree Gleeson, Caroline Blackwell
2004 Gleeson M, Clancy RL, Cox AJ, Gulliver SA, Hall ST, Cooper DM, 'Mucosal immune responses to infections in infants with acute life threatening events classified as 'near-miss' sudden infant death syndorme', FEMS Immunology and Medical Microbiology, 42 105-118 (2004) [C1]
DOI 10.1016/j.femsim.2004.06.019
Citations Scopus - 15Web of Science - 8
Co-authors Maree Gleeson
2004 Moscovis SM, Gordon AE, Al Madani OM, Gleeson M, Scott R, Roberts-Thomson JM, et al., 'Interleukin-10 and sudden infant death syndrome', FEMS Immunology and Medical Microbiology, 42 130-138 (2004) [C1]
DOI 10.1016/j.femsim.2004.06.020
Citations Scopus - 35Web of Science - 32
Co-authors Caroline Blackwell, Maree Gleeson, Rodney Scott
2004 Moscovis SM, Gordon AE, Hall ST, Gleeson M, Scott R, Roberts-Thomson JM, et al., 'Interleukin 1-b responses to bacterial toxins and sudden infant death syndrome', FEMS Immunology and Medical Microbiology, 42 139-145 (2004) [C1]
DOI 10.1016/j.femsim.2004.06.005
Citations Scopus - 27Web of Science - 25
Co-authors Maree Gleeson, Caroline Blackwell, Rodney Scott
2004 Blackwell CC, Moscovis SM, Gordon AE, Al Madani OM, Hall ST, Gleeson M, et al., 'Ethnicity, infection and sudden infant death syndrome', FEMS Immunology and Medical Microbiology, 42 53-65 (2004) [C1]
DOI 10.1016/j.femsim.2004.06.007
Citations Scopus - 31Web of Science - 21
Co-authors Rodney Scott, Maree Gleeson, Caroline Blackwell
2000 Reeves GE, Burns C, Hall ST, Gleeson M, Lemmert K, Clancy RL, 'The measurement of IgA and IgG transglutaminase antibodies in celiac disease: a comparison with current diagnostic methods', Pathology, 32 181-185 (2000) [C1]
Citations Scopus - 26Web of Science - 24
Co-authors Maree Gleeson
1999 Gleeson M, Hall S, McDonald W, Flanagan A, Clancy RL, 'Salivary IgA subclasses and infection risk in elite swimmers', Immunology & Cell Biology, 77 351-355 (1999) [C1]
Citations Scopus - 49Web of Science - 41
Co-authors Maree Gleeson
Show 17 more journal articles

Conference (8 outputs)

Year Citation Altmetrics Link
2014 Pringle K, Rae KM, Weatherall L, Hall S, Burns C, Smith R, et al., 'Effects of cigarette smoke and maternal inflammation in pregnancy on birth weight and gestational age at delivery in an Indigenous Australian population', Proceedings of the 57th ESA and 45th SRB Annual Conference, Melbourne (2014) [E3]
Co-authors Kirsty Pringle, Roger Smith, Caroline Blackwell, Kym Rae
2014 Ackland SP, Zdenkowski N, Adler K, Hall S, Jones D, 'MIDKINE AS A PREDICTIVE MARKER IN METASTATIC COLORECTAL CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Stephen Ackland
2013 Rae KM, Weatherall L, Clausen D, Maxwell C, Bowman M, Milgate P, et al., 'Gomeroi gaaynggal: Empowerment of Aboriginal communities to understand health implications of research in pregnancy', Proceedings of th 12th National Rural Health Conference, Adelaide (2013) [E1]
Co-authors Maria Bowman, Kym Rae, Roger Smith
2011 Weatherall LJ, Rae KM, Milgate P, Hall ST, Carlin A, Boyd J, et al., 'A place of connections: The Gomeroi Gaaynggal Centre', Proceedings of the 3rd Coalition for Research to Improve Aboriginal Health (CRIAH) Aboriginal Health Research Conference, Sydney, NSW (2011) [E3]
Co-authors Roger Smith, Kym Rae, Maria Bowman
2011 Moscovis SM, Hall ST, Gleeson M, Scott R, Blackwell CC, 'Genetics, gender and environment: Effects on inflammatory responses and implications for Indigenous women', Proceedings of the 3rd Coalition for Research to Improve Aboriginal Health (CRIAH) Aboriginal Health Research Conference, Sydney, NSW (2011) [E3]
Co-authors Maree Gleeson, Caroline Blackwell, Rodney Scott
2011 Ashhurst-Smith CIJ, Hall ST, Stuart JE, Liet E, Walker PJ, Dorrington R, et al., 'Alloiococcus otitidis: The major isolate from both urban and rural/remote children with chronic otitis media with effusion (glue ear)', Proceedings of the 3rd Coalition for Research to Improve Aboriginal Health (CRIAH) Aboriginal Health Research Conference, Sydney, NSW (2011) [E3]
Co-authors Caroline Blackwell, John Stuart
2011 Ashhurst-Smith CIJ, Hall ST, Stuart JE, Walker PJ, Dorrington R, Eisenberg R, et al., 'Antibiotic resistance among alloiococcus otitidis isolates from Indigenous and non-Indigenous children with otitis media with effusion (OME)', Proceedings of the 3rd Coalition for Research to Improve Aboriginal Health (CRIAH) Aboriginal Health Research Conference, Sydney, NSW (2011) [E3]
Co-authors John Stuart, Caroline Blackwell
2009 Hall ST, Tzanakaki G, Kremastinou J, Scott R, Blackwell CC, Titmarsh CJ, Moscovis SM, 'Comparison of cytokine gene polymorphisms among Greek patients with meningococcal or viral meningitis', The Pediatric Infectious Disease Journal, Brussels, Belgium (2009) [E3]
DOI 10.1097/inf.0b013e3181a51c24
Co-authors Caroline Blackwell, Rodney Scott
Show 5 more conferences
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Ms Sharron Hall

Position

Research Assistant
School of Medicine and Public Health
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Email sharron.hall@newcastle.edu.au
Phone (02) 4921 4028
Fax (02) 49214196

Office

Room HAPS31078
Building HAPS building
Location John Hunter Hospital

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