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Career Summary

Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle
  • Bachelor of Science, University of Newcastle

Research

Research keywords

  • Reproductive Biology

Research expertise

I obtained my PhD from the University of Newcastle (awarded 1999) working on a collaborative project with the Vertebrate Biocontrol CRC focused on characterising protein expression and function in male gametogenesis. This work helped to define to role of the male reproductive tract in post-testicular sperm maturation. I then undertook post-doctoral research in the Department of Cell Biology, Emory University, GA, USA (1999-2000). This work centred on the characterisation of a knockout mouse model bearing a targeted deletion of a key protein involved in gamete interactions. In 2001, I was recruited to the University of Newcastle as an Associate Lecturer in Biological Sciences and promoted to the position of Lecturer in 2004, Senior Lecturer in 2007, and Associate Professor in 2011. Since appointment I have established an active research program focusing on the use of human and animal models to characterise the processes of gamete maturation. In spermatozoa, I am working on a number of projects with the overriding goal of elucidating the molecular mechanisms that govern sperm activation and regulate gamete interactions. In folliculogenesis, I have focussed on cell signalling pathways that contribute to the initiation of primordial follicle activation and the effects of environmental ovotoxicants. These projects are of strategic importance in the design of post-testicular methods of fertility regulation, the development of assisted conception systems for the preservation of endangered species and elucidation of the causes of human male infertility.

My research niche complements existing programs in male germ cell development and ovarian biology within the Reproductive Science Group at the University of Newcastle. It also represents a strategically important subprogram of the University’s Priority Research Centre (PRC) for Reproductive Science. Furthermore, my research encompasses the National Research Priority goals of (i) safeguarding Australia (protecting Australia from invasive diseases and pests) and (ii) promoting and maintaining good health (a healthy start to life).

Languages

  • English

Fields of Research

CodeDescriptionPercentage
111499Paediatrics And Reproductive Medicine Not Elsewhere Classified50
060100Biochemistry And Cell Biology35
060899Zoology Not Elsewhere Classified15

Memberships

Editorial Board.

  • Editor - Molecular Human Reproduction

Learned Academy.

  • Member - Society for Reproductive Biology
  • Member - Society for the Study of Reproduction

Awards

Distinction.

2009Faculty of Science and IT Research Higher Degree Supervisor of the Year
The University of Newcastle (Australia)
Award for supervision excellence
2009The University of Newcastle Supervisor of the Year
The University of Newcastle (Australia)
Award for supervision excellence

Recognition.

2011Certificate of Recognition for excellent contribution to peer review
Human Reproduction (United Kingdom)
Certificate of Recognition for excellent contribution to Human Reproduction’s peer review process during 2011. Certificates are awarded to only the top 10% of the Journal’s reviewers as judged by the quality and timeliness of their reviews.
1998Finalist, Junior Scientist Competition
Australian Society for Reproductive Biology (Australia)

Research Award.

2012Award for Excellence in Reproductive Biology Research
Society for Reproductive Biology (Australia)
This award recognizes an excellent contributor working in the field of Reproductive Biology who is within 15 years post-receipt of their Doctorate. Criteria: The successful applicant will have demonstrated a substantial and sustained contribution to research in the field of Reproductive Biology. Evidence of such contribution to be considered includes: • Peer-Reviewed Publications • National and International Awards • National and International Invited Presentations • Student Completions • Grant Awards • Commercial and/or clinical translation • Institutional Responsibilities • Service to profession
2007New Investigator Grant
Hunter Medical Research Institute (Australia)
Grant awarded to junior scientists showing evidence of their potential to be group leaders
2006Lalor Foundation Award
American Society of Andrology (United States)
Awarded for presentation at the 31st Annual meeting of the American Society of Andrology, Chicago, IL, USA.
1998Student Travel Grant
American Society of Andrology (United States)
Awarded for presentation at the 23rd Annual meeting of the American Society of Andrology, Long Beach, CA, USA (1998)

Invitations

The Biology of Extracellular Molecular Chaperones
Novartis Foundation, United Kingdom (Conference Presentation - non published.)
2007

Collaboration

I have collaborative partnerships with a number of pre-eminent national and international scientists within the field of gamete biology. Similarly, I have established collaborations with IVF clinics to support the extension of my research program into the clinical domain. This nexus is critical for our ability to drive translational outcomes in understanding the aetiology of human male infertility.

Administrative

Administrative expertise

Service to the University

I am dedicated to building achievements in relation to University, Community and Professional Service. Since appointment to my current position I have made a significant commitment to University Service and related professional activities. Specifically, I focused on initiatives that enrich the student learning experience and promote a vibrant research culture, thus contributing to the status of the University's teaching and research profile. My committee membership aligns with my recognised strengths in teaching and research, and has included:

Faculty of Science and IT Student Recruitment Committee

School of Environmental and Life Sciences Honours Committee (Chair)

Discipline of Biological Sciences Postgraduate Committee

Analytical and Biomolecular Research Facility Advisory Committee

Reproductive Sciences OH&S Committee

Service to the profession

I review for a number of grant bodies such as NHMRC and Medical Research Council (UK). I also review for 12 specialist journals including Reproduction, Biology of Reproduction, Human Reproduction, Developmental Biology (~20 manuscripts/year) and serve as an Associate Editor for Molecular Human Reproduction.

Teaching

Teaching keywords

  • Biology

Teaching expertise

Undergraduate Teaching

Since my appointment in 2001, I have made a significant and sustained contribution to the teaching effort of the Discipline of Biological Sciences through the delivery of lectures and supervision of practical classes and tutorials across a broad range of courses (Levels 1000 – 4000). I strive for excellence in teaching and generate consistently high SEC and SET evaluations and qualitative feedback. My current teaching commitment includes:

BIOL1001 Cells, Molecules, and Organisms

BIOL1001 Gifted and Talented Program (Course coordinator)

BIOL2001 Molecular Laboratory Skills for Biological Sciences

BIOL2010 Biochemistry (Course coordinator)

BIOL2050 Molecular Genetics

BIOL3200 Cellular Biotechnology

BIOL3250 Biotechnology Placement

BIOL4110 - BIOL4220 BSc (Biology) Honours / BBiotech Honours (Program coordinator)

Research Training

Since 2001, I have supervised 6 PhD, 1 MPhil and 13 Honours students to successful completion of their research higher degrees. I am currently the principal supervisor of 3 PhD and 1 Honours student and the co-supervisor of an additional 3 PhD students. My commitment to research training is evidenced by the recent award of RHD Supervisor of the Year (2009), the University of Newcastle’s highest accolade for student supervision. The quality of my students is attested by the award of numerous platform and poster prizes at national and international meetings, including: best student poster at Lorne Protein (2003), Oozoa award for best student oral presentation at the Society for Reproduction (SRB) annual meeting (2008 & 2010), best student poster at the Australian Society for Biochemistry and Molecular Biology annual meeting (2010), best student poster at the International Symposium on Spermatology (Japan, 2010), and the SRB - New Investigator award (2011).

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Publications

No publications.

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Grants and Funding

Summary

Number of grants34
Total funding$4,450,995

For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2013 (6 grants)

Novel function of heat shock protein 2A in the regulation of human sperm-egg interactions$292,182
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Brett Nixon, Laureate Professor John Aitken, Professor Eileen McLaughlin
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$292,18220132015
GNo:G1200193

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Novel mechanisms for the regulation of sperm-oocyte interactions$20,000
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1300458

NucleoCounter SP100$14,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Laureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling, Ms Zamira Gibb, Mr Nenad Naumovski
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$14,00020132013
GNo:G1201175

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
SchemeRole
Near MissInvestigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1300700

Dynamin - role in sperm oocyte interaction$10,000
Funding Body: University of Newcastle

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon, Professor Adam McCluskey
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1300483

2011 (2 grants)

SLX4 - a key regulator of male germ cell development and DNA repair$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020112011
GNo:G1001000

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$15,00020112011
GNo:G1100028

2010 (6 grants)

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Associate Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$500,00020102010
GNo:G0190402

Laser microdissection microscopy system for cell and development biology$350,000
Funding Body: ARC (Australian Research Council)

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000
Funding Body: University of Newcastle

Monotremes provide a key to understanding the molecular biology of mammalian gamete evolution$270,000
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Brett Nixon, Dr Heath Ecroyd, Conjoint Associate Professor Russell Jones
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$270,00020102012
GNo:G0190056

Laser microdissection microscopy system for cell and development biology$215,000
Funding Body: University of Newcastle

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Professor Adam McCluskey, Associate Professor Brett Nixon, Professor John Rostas, Professor Eileen McLaughlin
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$30,00020102010
GNo:G1000051

2009 (5 grants)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

Characterization of the molecular basis of human sperm-oocyte interaction$474,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Brett Nixon, Professor Eileen McLaughlin, Dr M O'Bryan
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$474,00020092011
GNo:G0188867

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000
Funding Body: ARC (Australian Research Council)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

LAS-4000 Chemiluminescence imaging system$25,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Associate Professor Brett Nixon, Doctor Shaun Roman
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020092009
GNo:G0189852

2008 (4 grants)

Xenobiotics - ocidative stress in the mammalian ovary$362,625
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$362,62520082010
GNo:G0187620

Understanding the aetiology of human male infertility: Elucidation of the mechanisms underpinning sperm-egg interaction$21,650
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Brett Nixon, Professor Eileen McLaughlin
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$21,65020082008
GNo:G0188465

Characterization of the molecular basis of mouse sperm-oocyte interaction$18,285
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon, Professor Eileen McLaughlin
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$18,28520082008
GNo:G0188405

41st Annual Meeting of the Society for the Study of Reproduction $2,500
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020082008
GNo:G0188643

2007 (4 grants)

Chemokines and spermatogenesis: roles of SDF-1 and CXCR-4 in the establishment of spermatogenesis$20,000
Funding Body: University of Newcastle

Project Team
Professor Eileen McLaughlin, Doctor Shaun Roman, Associate Professor Brett Nixon
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0187197

Determination of the molecular processes involved in post-testicular development of sperm in the platypus and their relationship with sperm competition$16,471
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon, Conjoint Associate Professor Russell Jones
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$16,47120072007
GNo:G0187188

Validation of novel model to explain the functional activation of mouse spermatozoa$7,998
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon
SchemeRole
Pilot GrantChief Investigator
Total AmountFunding StartFunding Finish
$7,99820072007
GNo:G0187878

Validation of novel model to explain the functional activation of mouse spermatozoa$7,002
Funding Body: University of Newcastle - Faculty of Science & IT

Project Team
Associate Professor Brett Nixon
SchemeRole
Pilot GrantChief Investigator
Total AmountFunding StartFunding Finish
$7,00220072007
GNo:G0188360

2006 (1 grants)

PRC - Priority Research Centre for Reproductive Science$544,282
Funding Body: University of Newcastle

Project Team
Laureate Professor John Aitken, Professor Roger Smith, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Associate Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Conjoint Professor Ian Symonds
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$544,28220062013
GNo:G0186945

2005 (1 grants)

The initiation of fertilisation: Characterisation of the sperm receptor complex for the oocyte$9,000
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon, Laureate Professor John Aitken
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,00020052005
GNo:G0184742

2004 (3 grants)

Characterisation of a novel recepto-mediated signal transduction pathway in human spermatozoa.$14,000
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon, Conjoint Professor Leonie Ashman
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$14,00020042004
GNo:G0183444

Molecular basis of sperm-egg interaction: Identification of the receptor complex for ZP3$8,000
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon, Doctor Benjamin Curry
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,00020042004
GNo:G0183415

The role of the father in recurrent early pregnancy loss$7,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Brett Nixon
SchemeRole
Adamstown Lions ClubChief Investigator
Total AmountFunding StartFunding Finish
$7,00020042004
GNo:G0183756

2002 (1 grants)

The role of protein tyrosine phosphorylation in mouse sperm-oocyte interaction$12,000
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon
SchemeRole
Early Career Researcher GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,00020022002
GNo:G0182255

2001 (1 grants)

The role of protein tyrosine phosphorylation in mouse sperm-oocyte interaction$15,000
Funding Body: University of Newcastle

Project Team
Associate Professor Brett Nixon
SchemeRole
Early Career Researcher GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020012001
GNo:G0180831
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Research Supervision

Number of current supervisions8
Total current UoN Masters EFTSL0.1
Total current UoN PhD EFTSL2.6

For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20132017PhD (Biological Sciences)Co-SupervisorInvestigation into the Molecular Composition of Spermatozoa to Determine Consequences in Human Reproduction
20132017PhD (Biological Sciences)Principal SupervisorPhage Display as a Tool for Investigation of the Molecular Mechanisms Underlying Mouse Sperm-Oolemma Interactions
20132017PhD (Biological Sciences)Co-SupervisorConsequences of Chronic Exposure of the Male Germ Line to Xenobiotics
20122014M Philosophy (Biological Sc)Co-SupervisorCell Biology of Equine Spermatoza
20122016PhD (Biological Sciences)Principal SupervisorThe Function of Molecular Chaperones in The Regulation of Human Sperm-Egg Interaction.
20122016PhD (Biological Sciences)Co-SupervisorCell Biology of Apoptosis in the Oocyte
20102014PhD (Biological Sciences)Principal SupervisorInvestigating Membrane Trafficking Proteins and Their Potential Role During Fertilisation
20092013PhD (Biological Sciences)Co-SupervisorThe Consequences of Acrylaminde Exposure of the Male Germ Line

Past Supervision

YearProgramSupervisor TypeResearch Title
2013PhD (Biological Sciences)Principal SupervisorNew Insights into the Molecular Basis of Human Sperm-Egg Interaction
2013PhD (Biological Sciences)Co-SupervisorRegulation of the Transition from Gonocytes to Spermatogonia
2012PhD (Biological Sciences)Principal SupervisorThe Molecular Basis of Sperm - Oocyte Interactions
2012PhD (Biological Sciences)Co-SupervisorXenobiotics; Effects on Female Fertility
2010PhD (Biological Sciences)Co-SupervisorSignificance of Mitochondrial Reactive Oxygen Species Production in Male Infertility
2009PhD (Biological Sciences)Co-SupervisorThe Molecular Basis of Human Sperm-Zona Pellucida Interaction
2007M Philosophy (Biological Sc)Co-SupervisorIdentification of NADPH Oxidase in Mouse Spermatozoa
2007PhD (Biological Sciences)Co-SupervisorThe Development of a Novel Electrophoretic System for the Isolation of Human Spermatozoa
2005PhD (Biological Sciences)Co-SupervisorThe Molecular Basis of Sperm-Oocyte Interaction in the Mouse
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Associate Professor Brett Nixon

Work Phone(02) 4921 6977
Fax(02) 4921 6923
Email
PositionAssociate Professor
School of Environmental and Life Sciences
Faculty of Science and Information Technology
The University of Newcastle, Australia
Focus AreaBiological Sciences
Office
LS4-40,
Life Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/brett-nixon