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Dr Doug Smith

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Anatomy)

Career Summary

Biography

Eleven peer-reviewed research publications from PhD studies Awarded CJ Martin fellowship Complete change in direction of research to acquire state-of-the-art techniques in USA Returned to Australia and established single-cell genomics capability Establishing new research program into the effects of aging on brain function. Establishing collaborations with groups studying addiction and depression

Research Expertise
The main aim of my lab's research is to better understand the effects of ageing on nervous system function. It is well known that the world's population is ageing and soon there will be more people over the age of 65 than there are children. If we are to improve the quality of life of the aged, then we must first understand how ageing affects the body's various physiological systems. As the nervous system has an important role in most functions, its preservation with ageing is paramount.

We are primarily using molecular approaches and focusing on ageing-related changes in the cell's two genomes - the nuclear and mitochondrial genomes. It is well-established that both genomes accumulate mutations with ageing, although it is not completely clear whether these mutations are more detrimental to cell function if they accumulate more so in one of the genomes as opposed to the other. It is also not known whether the mutation accumulations occur in a cell-specific manner. This is particularly important for the nervous system with its highly heterogeneous cell population. A number of nervous system functions appear more susceptible to the ageing process than others. For example, the special senses of hearing, vision and balance are particularly prone, although it remains to be determined whether the peripheral components of these systems (cochlea, retina, and vestibular apparatus, respectively) are more affected than their central nervous system connections and processes.

Cognitive function and motor control are two more nervous system functions that are affected by the ageing process as can be readily observed in the aged population. We are characterising the genomic changes in specific populations of cells within these ageing-affected systems. For example, using state-of-the-art, laser based microdissection, we can collect midbrain dopamine neurons, which play an important role in motor control as can be appreciated from Parkinson's disease, at different ages and determine changes in mitochondrial DNA and the expression level of various genes.

Similar approaches are being used for spinal cord motor neurons and inner ear vestibular hair cells. Knowing how ageing affects the nervous system is important, but we also need to be able to intervene if we are to improve the quality of life of aged individuals. Calorie restriction, whereby the daily calorie intake is reduced by 20-40% (but without malnutrition), is the only presently known intervention that retards the ageing process, at least in animal models. We are establishing CR to determine whether the ageing-related changes we see in the various cell populations of interest are modified by this intervention. If this is the case, we will then set out to determine how CR achieves this.

Research methods used in the lab include: Animal models Laser based microdissection Immunocytochemistry RNA and DNA techniques Real-time and end-point PCR Immunofluorescence microscopy Cryosectioning


Qualifications

  • Doctor of Philosophy, University of Queensland

Keywords

  • Aging and Brain Function
  • Anatomy
  • Animal Models
  • Cell Culture Models
  • Developmental Neurobiology
  • Ergonomics
  • Gene Expression
  • Immunocytochemistry
  • Mitochondrial genomics
  • Modern Techniques
  • Molecular Biology
  • Neuroanatomy
  • Neurobiology
  • Physiology
  • Single Cell Genomics
  • Viral Vectors

Fields of Research

CodeDescriptionPercentage
060199Biochemistry and Cell Biology not elsewhere classified25
110399Clinical Sciences not elsewhere classified50
170199Psychology not elsewhere classified25

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2014 - Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/03/2005 - 21/06/2015AcademicUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/1997 - 1/04/2004Research ScientistUniversity of California, San Diego
Department of Pediatrics, School of Medicine UCSD
United States

Awards

Research Award

YearAward
1995CJ Martin Fellowship
Unknown
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (36 outputs)

YearCitationAltmetricsLink
2015McIlroy DJ, Bigland M, White AE, Hardy BM, Lott N, Smith DW, Balogh ZJ, 'Cell necrosis-independent sustained mitochondrial and nuclear DNA release following trauma surgery.', J Trauma Acute Care Surg, 78 282-288 (2015)
DOI10.1097/TA.0000000000000519Author URL
CitationsWeb of Science - 1
Co-authorsZsolt Balogh
2014James MH, Quinn RK, Ong LK, Levi EM, Charnley JL, Smith DW, et al., 'mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIa levels.', Neuropsychopharmacology, 39 1694-1702 (2014) [C1]
DOI10.1038/npp.2014.16Author URL
CitationsScopus - 1
Co-authorsLinkooi Ong, Christopher Dayas, Phil Dickson
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery', Journal of Critical Care, 29 1133.e1-1133.e5 (2014)
DOI10.1016/j.jcrc.2014.07.013
Co-authorsPhilip Hansbro, Zsolt Balogh, Gough Au
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery', Journal of Critical Care, 29 1133.e1-1133.e5 (2014) [C1]

Introduction: Neutrophil extracellular traps (NETs) have not been demonstrated after trauma and subsequent surgery. Neutrophil extracellular traps are formed from pure mitochondrial DNA (mtDNA) under certain conditions, which is potently proinflammatory. We hypothesized that injury and orthopedic trauma surgery would induce NET production with mtDNA as a structural component. Methods: Neutrophils were isolated 8 trauma patients requiring orthopedic surgery postinjury and up to 5 days postoperatively. Four healthy volunteers provided positive and negative controls. Total hip replacement patients acted as an uninjured surgical control group. Neutrophil extracellular traps were visualized with DNA (Hoechst 33342TM/Sytox Green/MitoSox/MitoTracker) stains using live cell fluorescence microscopy with downstream quantitative polymerase chain reaction analysis of DNA composition. Results: Neutrophil extracellular traps were present after injury in all 8 trauma patients. They persisted for 5 days postoperatively. Delayed surgery resulted in NET resolution, but they reformed postoperatively. Total hip replacement patients developed NETs postoperatively, which resolved by day 5. Quantitative polymerase chain reaction analysis of NET-DNA composition revealed that NETs formed after injury and surgery were made of mtDNA with no detectable nuclear DNA component. Conclusions: Neutrophil extracellular traps formed after major trauma and subsequent surgery contain mtDNA and represent a novel marker of heightened innate immune activation. They could be considered when timing surgery after trauma to prevent systemic NET-induced inflammatory complications.

DOI10.1016/j.jcrc.2014.07.013
CitationsScopus - 3
Co-authorsZsolt Balogh, Philip Hansbro, Gough Au
2014Thomas J, Garg ML, Smith DW, 'Dietary resveratrol supplementation normalizes gene expression in the hippocampus of streptozotocin-induced diabetic C57Bl/6 mice', Journal of Nutritional Biochemistry, 25 313-318 (2014) [C1]

Diabetes is associated with cognitive impairment and brain aging, with alterations in hippocampal neurogenesis and synaptic plasticity implicated in these changes. As the prevalence of diabetes continues to rise, readily implemented strategies are increasingly needed in order to protect the brain's cognitive functions. One possibility is resveratrol (RES) (3,5,4- trihydroxystilbene), a polyphenol of the phytoalexin family that has been shown to be protective in a number of neuropathology paradigms. In the present study, we sought to determine whether dietary supplementation with RES has potential for the protection of cognitive functions in diabetes. Diabetes was induced using streptozotocin, and once stable, animals received AIN93G rodent diet supplemented with RES for 6 weeks. Genome-wide expression analysis was conducted on the hippocampus and genes of interest were confirmed by quantitative, real-time polymerase chain reaction. Genome-wide gene expression analysis of the hippocampus revealed that RES supplementation of the diabetic group resulted in 481differentially expressed genes compared to non-supplemented diabetic mice. Intriguingly, gene expression that was previously found significantly altered in the hippocampus of diabetic mice, and that is implicated in neurogenesis and synaptic plasticity (Hdac4, Hat1, Wnt7a, ApoE), was normalized following RES supplementation. In addition, pathway analysis revealed Jak-Stat signaling was the most significantly enriched pathway. The Jak-Stat pathway induces a pro-inflammatory signaling cascade, and we found most genes involved in this cascade (e.g. Il15, Il22, Socs2, Socs5) had significantly lower expression following RES supplementation. These data indicate RES could be neuroprotective and beneficial for the maintenance of cognitive function in diabetes. © 2014 Elsevier Inc.

DOI10.1016/j.jnutbio.2013.11.005
CitationsScopus - 4Web of Science - 4
Co-authorsManohar Garg
2014Parkinson GM, Dayas CV, Smith DW, 'Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat.', Current aging science, 7 155-160 (2014) [C2]
Co-authorsChristopher Dayas
2014James MH, Campbell EJ, Walker FR, Smith DW, Richardson HN, Hodgson DM, Dayas CV, 'Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats', Frontiers in Behavioral Neuroscience, 8 (2014) [C1]
DOI10.3389/fnbeh.2014.00244
CitationsScopus - 2Web of Science - 2
Co-authorsDeborah Hodgson, Christopher Dayas, Rohan Walker
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery.', Journal of critical care, 29 1133.e1-1133.e5 (2014) [C1]
DOI10.1016/j.jcrc.2014.07.013
CitationsScopus - 1
Co-authorsZsolt Balogh, Philip Hansbro, Gough Au
2013Balogh ZJ, McIlroy DJ, Smith DW, Hansbro PM, 'The origin and the role of mitochondrial DNA in postinjury inflammation', Journal of Critical Care, 28 1099-1100 (2013) [C3]
DOI10.1016/j.jcrc.2013.08.027
CitationsScopus - 2Web of Science - 2
Co-authorsZsolt Balogh, Philip Hansbro
2013Thomas J, Garg ML, Smith DW, 'Altered expression of histone and synaptic plasticity associated genes in the hippocampus of streptozotocin-induced diabetic mice', Metabolic Brain Disease, 28 613-618 (2013) [C1]
DOI10.1007/s11011-013-9418-yAuthor URL
CitationsScopus - 4Web of Science - 4
Co-authorsManohar Garg
2013Thomas J, Garg ML, Smith DW, 'Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice', Journal of Nutritional Biochemistry, 24 1735-1740 (2013) [C1]

The hippocampus is an important brain structure for multiple cognitive functions, including memory formation. It is particularly sensitive to insults, such as stress, ischemia, and aging; all of these can affect hippocampal and therefore cognitive function. To understand the potential of diet for the preservation of hippocampal function, we investigated the effects of dietary supplementation with resveratrol (RES) or docosahexaenoic acid (DHA), or their combination, on hippocampal gene expression in adult C57BL/6 mice. Animals in the supplemented group received either 50 mg/kg/day of RES or DHA, while the combination group received 50 mg/kg/day of each supplement. Dietary supplements were mixed with the AIN93G diet, and supplementation lasted 6 weeks. The control group received AIN93G diet alone for the same period. At the end of the experiment, the hippocampi were processed for genome-wide gene expression and pathway analyses. Most of the genes that were significantly altered were associated with inflammatory responses as determined by pathway analysis. RES-supplemented animals showed decreased expression of IL-6 ( P=001), MAPKapk2 ( P=015), and increased expression for PI3. KR2 ( P=034) and Wnt7a ( P=004) expression. DHA-supplemented animals showed a decreased IL-6 ( P=003) and an increased Wnt7a ( P=003) expression. Animals on the combination diet showed a decreased IL-6 ( P=005) and Apolipoprotien E ( ApoE) ( P=035) expression. Our findings demonstrate that hippocampal gene expression is significantly altered by all three dietary supplementation regimes. Moreover, our analysis indicates that RES and DHA likely exert their beneficial effects through antiinflammatory mechanisms. © 2013 Elsevier Inc.

DOI10.1016/j.jnutbio.2013.03.002
CitationsScopus - 1Web of Science - 1
Co-authorsManohar Garg
2013Cahif A, Parkinson GM, Dayas CV, Smith DW, 'Characterisation of mitochondrial DNA deletions by long-PCR in central nervous system regions of young, middle- and old-aged rats.', Current Aging Science, 6 232-238 (2013) [C1]
CitationsScopus - 1
Co-authorsChristopher Dayas
2013Brown AL, Day TA, Dayas CV, Smith DW, 'Purity and Enrichment of Laser-Microdissected Midbrain Dopamine Neurons', BIOMED RESEARCH INTERNATIONAL, (2013) [C1]
DOI10.1155/2013/747938Author URL
CitationsScopus - 1
Co-authorsChristopher Dayas, Trevor Day
2012Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?', BMC Neuroscience, 13 1-12 (2012) [C1]
CitationsScopus - 5Web of Science - 7
Co-authorsRohan Walker, Trevor Day, Peter Dunkley
2012Dayas CV, Smith DW, Dunkley PR, 'An emerging role for the mammalian Target of Rapamycin (mTOR) in 'pathological' protein translation: Relevance to cocaine addiction', Frontiers in Pharmacology, 3 1-12 (2012) [C1]
CitationsScopus - 9Web of Science - 7
Co-authorsPeter Dunkley, Christopher Dayas
2011James MH, Charnley JL, Flynn JR, Smith DW, Dayas CV, 'Propensity to 'relapse' following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei', Neuroscience, 199 235-242 (2011) [C1]
CitationsScopus - 18Web of Science - 17
Co-authorsChristopher Dayas
2011James MH, Charnley JL, Levi EM, Jones E, Yeoh JW, Smith DW, Dayas CV, 'Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking', International Journal of Neuropsychopharmacology, 14 684-690 (2011) [C1]
DOI10.1017/s1461145711000423
CitationsScopus - 44Web of Science - 42
Co-authorsChristopher Dayas
2011Brown AL, Flynn JR, Smith DW, Dayas CV, 'Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals', International Journal of Neuropsychopharmacology, 14 1099-1110 (2011) [C1]
CitationsScopus - 11Web of Science - 9
Co-authorsChristopher Dayas
2010James MH, Charnley JL, Jones E, Levi E, Yeoh JW, Flynn JR, et al., 'Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour', Plos One, 5 e12980 (2010) [C1]
DOI10.1371/journal.pone.0012980
CitationsScopus - 23Web of Science - 21
Co-authorsChristopher Dayas
2009McInerny SC, Brown AL, Smith DW, 'Region-specific changes in mitochondrial D-loop in aged rat CNS', Mechanisms of Ageing and Development, 130 343-349 (2009) [C1]
DOI10.1016/j.mad.2009.01.008
CitationsScopus - 13Web of Science - 9
2009Brown AL, Smith DW, 'Improved RNA preservation for immunolabeling and laser microdissection', RNA: A Publication of the RNA Society, 15 2364-2374 (2009) [C1]
DOI10.1261/rna.1733509
CitationsScopus - 10Web of Science - 9
2007Smith DW, Jinnah HA, 'Role of neuronal nitric oxide in the dopamine deficit of HPRT-deficient mice', Metabolic Brain Disease, 22 39-43 (2007) [C1]
DOI10.1007/s11011-007-9044-7
CitationsScopus - 3Web of Science - 3
2004Smith DW, Friedmann T, 'Discrepant effects of culture conditions on survival and function of dopaminergic neurons.', Neuroreport, 15 1025-1028 (2004) [C1]
DOI10.1097/00001756-200404290-00018
2003Tokumine J, Kakinohana O, Cizkova D, Smith DW, Marsala M, 'Changes in spinal GDNF, BDNF and NT-3 expression after transient spinal cord ischemia in the rat.', Neuroscience Research, 74 552-561 (2003) [C1]
DOI10.1002/jnr.10760
2003Smith DW, Day TA, 'Catecholamine and oxytocin cells respond to hypovolaemia as well as hypotension', Neuroreport, 14 1493-1495 (2003) [C1]
DOI10.1097/00001756-200308060-00018
Co-authorsTrevor Day
2002Visser JE, Smith DW, Fried T, Rothstein JD, Jinnah HA, 'Oxidative stress and dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease.', Brain Res Dev Brain Res, (2002) [C1]
2000Smith D, 'Characterization of the Dopamine Defect in Primary Cultures of Dopaminergic Neurons from Hypoxanthine Phosphoribosyltransferase Knockout Mice', Molecular Therapy, 1 486-491 (2000)
DOI10.1006/mthe.2000.0057
1999Buller KM, Smith DW, Day TA, 'Differential recruitment of hypothalamic neuroendocrine and ventrolateral medulla catecholamine cells by non-hypotensive and hypotensive hemorrhages', BRAIN RESEARCH, 834 42-54 (1999)
DOI10.1016/S0006-8993(99)01539-5Author URL
CitationsWeb of Science - 59
1999Buller KM, Smith DW, Day TA, 'NTS catecholamine cell recruitment by hemorrhage and hypoxia', NEUROREPORT, 10 3853-3856 (1999)
DOI10.1097/00001756-199912160-00024Author URL
CitationsWeb of Science - 26
1995SMITH DW, SIBBALD J, KHANNA S, DAY TA, 'RAT VASOPRESSIN CELL RESPONSES TO SIMULATED HEMORRHAGE - STIMULUS-DEPENDENT ROLE FOR A1 NORADRENERGIC NEURONS', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 268 R1336-R1342 (1995)
Author URL
CitationsWeb of Science - 40
1995SMITH DW, DAY TA, 'HYPOVOLEMIC AND OSMOTIC STIMULI INDUCE DISTINCT PATTERNS OF C-FOS EXPRESSION IN THE RAT SUBFORNICAL ORGAN', BRAIN RESEARCH, 698 232-236 (1995)
DOI10.1016/0006-8993(95)00975-VAuthor URL
CitationsWeb of Science - 22
1995Smith DW, Buller KM, Day TA, 'Role of ventrolateral medulla catecholamine cells in hypothalamic neuroendocrine cell responses to systemic hypoxia', JOURNAL OF NEUROSCIENCE, 15 7979-7988 (1995)
Author URL
CitationsWeb of Science - 70
1994SMITH DW, DAY TA, 'C-FOS EXPRESSION IN HYPOTHALAMIC NEUROSECRETORY AND BRAIN-STEM CATECHOLAMINE CELLS FOLLOWING NOXIOUS SOMATIC STIMULI', NEUROSCIENCE, 58 765-775 (1994)
DOI10.1016/0306-4522(94)90453-7Author URL
CitationsWeb of Science - 49
1994KHANNA S, SIBBALD J, SMITH DW, DAY TA, 'INITIATION OF RAT VASOPRESSIN CELL RESPONSES TO SIMULATED HYPOTENSIVE HEMORRHAGE', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 267 R1142-R1149 (1994)
Author URL
CitationsWeb of Science - 20
1993SMITH DW, DAY TA, 'NEUROCHEMICAL IDENTIFICATION OF FOS-POSITIVE NEURONS USING 2-COLOR IMMUNOPEROXIDASE STAINING', JOURNAL OF NEUROSCIENCE METHODS, 47 73-83 (1993)
DOI10.1016/0165-0270(93)90023-KAuthor URL
CitationsWeb of Science - 41
1992DAY TA, SIBBALD J, SMITH DW, 'A1-NEURONS AND EXCITATORY AMINO-ACID RECEPTORS IN RAT CAUDAL MEDULLA MEDIATE VAGAL EXCITATION OF SUPRAOPTIC VASOPRESSIN CELLS', BRAIN RESEARCH, 594 244-252 (1992)
DOI10.1016/0006-8993(92)91131-WAuthor URL
CitationsWeb of Science - 43
Show 33 more journal articles

Conference (12 outputs)

YearCitationAltmetricsLink
2014Khan SI, Hübner PP, Smith DW, Brichta AM, Migliaccio AA, 'Ageing reduces vestibulo-ocular reflex adaptation in mice J Vestib Res', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science (2014) [E3]
DOI10.3233/VES-140517
Co-authorsAlan Brichta
2013Bigland M, Parkinson G, Brichta AM, Smith DW, 'Evidence for mitochondrial DNA deletions in vestibular hair cells of the aged rat', Proceedings of the Australian Neuroscience Society, Melbourne (2013) [E3]
Co-authorsAlan Brichta
2012Parkinson GM, Smith DW, 'Age-related increase in mitochondrial DNA copy number in midbrain dopamine neurons of the rat', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012James MH, Charnley JL, Levi EM, Dunkley PR, Smith DW, Dickson PW, Dayas CV, 'A role for the mTOR pathway in the development of addiction', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsChristopher Dayas, Phil Dickson, Peter Dunkley
2012Thomas J, Smith DW, Garg ML, 'Early molecular signature of neuro-protection in hippocampus of resveratrol diet fed C57BL/6 mice', Resveratrol 2012. 2nd International Conference of Resveratrol and Health, Leicester, UK (2012) [E3]
Co-authorsManohar Garg
2012Brown AL, Flynn JR, Dayas CV, Smith DW, 'Altered gene expression in cell signalling pathways of midbrain dopamine neurons from addiction and relapse vulnerable animals', Drug and Alcohol Review: Abstracts of the Australasian Professional Society on Alcohol and other Drugs Conference 2012, Melbourne, Vic (2012) [E3]
Co-authorsChristopher Dayas
2012Dayas CV, Quinn RK, Goldie BJ, Brown AM, Levi EM, Smith DW, Cairns MJ, 'Association of miRNAs with addiction-relevant synaptic plasticity genes', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
Co-authorsMurray Cairns, Christopher Dayas
2011Thomas J, Smith DW, Garg ML, 'Dietary supplementation with resveratrol normalizes histone deacetylase (HDAC4) in the hippocampus of streptozotocin-induced diabetic mice', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsManohar Garg
2011Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Alteration of neurotrophic factor pathway gene expression in the rat infralimbic medial prefrontal cortex by subchronic restraint stress is reversed by fluoxetine', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
Co-authorsPeter Dunkley, Trevor Day, Rohan Walker
2010Thomas J, Smith DW, Garg ML, 'Dietary supplementation with resveratrol reduces erythrocyte arachidonic and docosahexaenoic acids levels in diabetic mice', Proceedings of the Nutrition Society of Australia, Perth, WA (2010) [E3]
Co-authorsManohar Garg
2007McInerny SC, Brown AL, Smith DW, 'Brain region-specific decrease in mitochondrial D-loop in aged rats (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
1995Day TA, Smith DW, Buller KM, 'Regulation of neurosecretory cell activity by A1 noradrenergic neurons', 1st Joint World Congress of Neurohypophysis and Vasopressin, Nasu Japan (1995)
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Grants and Funding

Summary

Number of grants15
Total funding$4,719,925

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $25,000

Maintaining our cognitive abilities as we grow old: preventing the effects of ageing on the brain$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Doug Smith, Doctor Frederick Walker
SchemeProject Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500078
Type Of FundingExternal
CategoryEXTE
UONY

20131 grants / $35,000

20122 grants / $313,375

The effects of ageing on the peripheral vestibular system. Can ageing-related functional decline be reduced or prevented?$298,375

Funding body: Garnett Passe and Rodney Williams Memorial Foundation

Funding bodyGarnett Passe and Rodney Williams Memorial Foundation
Project TeamDoctor Doug Smith
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100935
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

2011 Emerging Research Leaders Program$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Doug Smith
SchemeEmerging Research Leaders Program
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200307
Type Of FundingInternal
CategoryINTE
UONY

20111 grants / $25,000

Brain Mechanisms Conferring Psychostimulant Addiction$25,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas, Emeritus Professor Peter Dunkley, Doctor Doug Smith
SchemeNear Miss Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1001052
Type Of FundingInternal
CategoryINTE
UONY

20103 grants / $599,000

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

20081 grants / $538,500

Dopamine mechanisms conferring resilience to depression: A new antidepressant target$538,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Trevor Day, Emeritus Professor Peter Dunkley, Professor David Pow, Doctor Doug Smith
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0187604
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20072 grants / $40,000

Vulnerability to depression: the role of dopamine pathways$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Trevor Day, Emeritus Professor Peter Dunkley, Doctor Doug Smith, Professor David Pow
SchemeNear Miss Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187196
Type Of FundingInternal
CategoryINTE
UONY

Characterisation of the brain mechanisms linking vulnerability to stress and vulnerability to drug addiction$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Trevor Day, Doctor Chris Dayas, Doctor Doug Smith
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187255
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20042 grants / $13,679

Characterisation of age-related gene expression changes in midbrain dopamine neurons$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Doug Smith
SchemeNew Staff Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184998
Type Of FundingInternal
CategoryINTE
UONY

Society for Neuroscience Annual Meeting, 23-27 October 2004$1,679

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Doug Smith
SchemeTravel Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184814
Type Of FundingInternal
CategoryINTE
UONY

20031 grants / $2,489,371

Genetic aberrations in HPRT deficiency$2,489,371

Funding body: National Institute of Neurological Disorders (NIH)

Funding bodyNational Institute of Neurological Disorders (NIH)
Project Team
SchemeProject
RoleInvestigator
Funding Start2003
Funding Finish2007
GNo
Type Of FundingExternal
CategoryEXTE
UONY

20011 grants / $641,000

Array screening for Lesch-Nyhan disese$641,000

Funding body: NICH (NIH)

Funding bodyNICH (NIH)
Project Team
SchemeR21
RoleInvestigator
Funding Start2001
Funding Finish2003
GNo
Type Of FundingExternal
CategoryEXTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Nucleotide Excision Repair of UVA-Induced DNA Damage: Regulation in Sunlight-Induced Melanoma
Health, Faculty of Health and Medicine
Co-Supervisor
2012Ageing of the Inner Ear Balance System
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012The Role of Mitochondrial DNA in the Post-Injury "Inflammatory" Response Following Major Trauma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2011Ageing of the Somatic Motor Nervous System: A Mitochondrial and Nuclear Genome Perspective
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2007Role of dopamine in depression
Medical Science, University of Newcastle
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) and Orexin in Drug-Seeking and Addiction-Related Behaviours
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2013Effects of Anti-Inflammatory Bioactives on Diabetes-Induced Changes in Cognition-Related Gene Expression in the Hippocampus
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2012Molecular Correlates of Dopamine Signalling in Addiction Vulnerability
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012Dopaminergic Pathway Imbalance in the Neurobiology of Depression
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2006Role of mitochondrial D-loop in aging brain
Medical Science, University of Newcastle
Principal Supervisor
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Dr Doug Smith

Position

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Anatomy

Contact Details

Emaildouglas.smith@newcastle.edu.au
Phone(02) 4921 7108
Fax(02) 4921 8667

Office

RoomMS306B
BuildingMedical Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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