Dr Vicki Maltby

Research Fellow

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Research Expertise

Epigenetics and Medical Genetics



Teaching Expertise

Basic Genetics


Qualifications

  • PhD, University of British Columbia - Canada
  • Bachelor of Science, University of British Columbia - Canada

Keywords

  • Epigenetics
  • Genetics
  • Histone Modification
  • Immunology
  • Medical Genetics

Fields of Research

CodeDescriptionPercentage
060404Epigenetics (incl. Genome Methylation and Epigenomics)80
110311Medical Genetics (excl. Cancer Genetics)10
110706Immunogenetics (incl. Genetic Immunology)10

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
17/02/2015 - 30/09/2017Research FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/02/2012 - Post Doctoral FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/05/2004 - 1/09/2004TechnicianPacific Agri-Food Research Centre
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (9 outputs)

YearCitationAltmetricsLink
2014Maltby VE, Crock PA, Luedecke DK, 'A rare case of pituitary infarction leading to spontaneous tumour resolution and CSF-sella syndrome in an 11-year-old girl and a review of the paediatric literature', JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 27 939-946 (2014) [C3]
DOI10.1515/jpem-2014-0143Author URL
2014Maltby VE, Crock PA, Luedecke DK, 'A rare case of pituitary infarction leading to spontaneous tumour resolution and CSF-sella syndrome in an 11-year-old girl and a review of the paediatric literature', JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, 27 939-946 (2014) [C3]
DOI10.1515/jpem-2014-0143Author URL
2014Smith CJA, Bensing S, Maltby VE, Zhang M, Scott RJ, Smith R, et al., 'Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis', Pituitary, 17 22-29 (2014)
DOI10.1007/s11102-013-0461-9
Co-authorsRoger Smith, Rodney Scott
2014Smith CJA, Bensing S, Maltby VE, Zhang M, Scott RJ, Smith R, et al., 'Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis', Pituitary, 17 22-29 (2014) [C1]

Lymphocytic hypophysitis is an organ-specific autoimmune disease characterised by destruction of pituitary hormone-secreting cells due to attack by self-reactive T lymphocytes. Th... [more]

Lymphocytic hypophysitis is an organ-specific autoimmune disease characterised by destruction of pituitary hormone-secreting cells due to attack by self-reactive T lymphocytes. The spectrum of pituitary autoantibodies characterised by indirect immunofluorescence (IF) in these patients has not been substantially defined. The purpose of this study was to determine the spectrum of pituitary autoantibodies in 16 lymphocytic hypophysitis patients. Pituitary sections were prepared from guinea pigs and sera from 16 lymphocytic hypophysitis patients (13 biopsy proven and 3 suspected cases) and 13 healthy controls were evaluated for immunoreactivity to the pituitary tissue by immunofluorescence. A single patient was found to have high titre pituitary autoantibodies against guinea pig pituitary tissue. Immunoreactivity was directed against cells of the intermediate lobe. We present the case report of the patient who is a 24 year old woman that presented with headaches, polyuria and polydipsia. A uniformly enlarged pituitary mass was visible on MRI and a diagnosis of suspected lymphocytic hypophysitis was made. Based on our IF study, we postulate this patient has an autoimmune process directed towards the major cell type in the intermediate lobe, the melanotroph. Pre-adsorption with peptides representing adrenocorticotropic hormone, a-melanocyte stimulating hormone or ß-endorphin did not affect the IF signal suggesting our patient's pituitary autoantibodies may target some other product of Proopiomelanocortin (POMC) processing, such as corticotrophin-like intermediate peptide or ¿-lipoprotein. Alternatively, the autoantibodies may target a peptide completely unrelated to POMC processing. © 2013 Springer Science+Business Media New York.

DOI10.1007/s11102-013-0461-9
CitationsWeb of Science - 1
Co-authorsRoger Smith, Rodney Scott
2012Maltby VE, Martin BJ, Brind'Amour J, Chruscicki AT, McBurney KL, Schulze JM, et al., 'Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae', Proceedings of the National Academy of Sciences of USA, 109 8505-8510 (2012) [C1]
CitationsScopus - 11Web of Science - 10
2012Maltby VE, Martin BJ, Schulze JM, Johnson IJ, Hentrich T, Sharma A, et al., 'Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin', Molecular and Cellular Biology, 32 3479-3485 (2012) [C1]
CitationsScopus - 22Web of Science - 20
2010Chruscicki AT, MacDonald VE, Young BP, Loewen CJ, Howe LJ, 'Critical Determinants for Chromatin Binding by Saccharomyces cerevisiae Yng1 Exist Outside of the Plant Homeodomain Finger', Genetics, 185 469-477 (2010) [C1]
CitationsScopus - 5Web of Science - 4
2009MacDonald VE, Howe LJ, 'Histone acetylation: where to go and how to get there.', Epigenetics, 4 139-143 (2009) [C2]
CitationsScopus - 54Web of Science - 50
2006Martin DG, Baetz K, Shi X, Walter K, MacDonald VE, Wlodarski MJ, et al., 'The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.', Molecular and Cellular Biology, 26 7871-7879 (2006) [C1]
CitationsScopus - 103Web of Science - 104
Show 6 more journal articles

Conference (1 outputs)

YearCitationAltmetricsLink
2014Murray HC, Maltby VE, Bowden NA, 'Nucleotide excision repair in response to UVA is deficient in melanoma.', Pigment Cell and Melanoma Research, Singapore (2014) [E3]
DOI10.1111/pcmr.12292
Co-authorsNikola Bowden
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Grants and Funding

Summary

Number of grants7
Total funding$664,675

Click on a grant title below to expand the full details for that specific grant.


20145 grants / $660,000

Characterization of epigenetic profiles in patients with Multiple Sclerosis $225,000

Funding body: Multiple Sclerosis Research Australia Limited

Funding bodyMultiple Sclerosis Research Australia Limited
Project TeamDoctor Vicki Maltby
SchemePostdoctoral Fellowship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300732
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Characterization of epigenetic profiles in patients with Multiple Sclerosis $225,000

Funding body: Multiple Sclerosis Research Australia Limited

Funding bodyMultiple Sclerosis Research Australia Limited
Project TeamDoctor Vicki Maltby
SchemePostdoctoral Fellowship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300732
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Characterization of Epigenetic Profiles in Patients with Multiple Sclerosis$150,000

Funding body: Canadian Institutes of Health Research

Funding bodyCanadian Institutes of Health Research
Project TeamDoctor Vicki Maltby, Professor Rodney Scott
SchemeFellowship Award
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301250
Type Of FundingInternational - Competitive
Category3IFA
UONY

Characterization of non-genetic factors causing Multiple Sclerosis$35,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Vicki Maltby
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401414
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Antipituitary Autoantibodies and Pituitary Target Autoantigen Characterization$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Vicki Maltby, Conjoint Associate Professor Patricia Crock, Professor Rodney Scott
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301324
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20131 grants / $3,655

43rd Annual Scientific Meeting of the Australasian Society for immunology, New Zealand 2-5 December 2013$3,655

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Vicki Maltby
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300971
Type Of FundingInternal
CategoryINTE
UONY

20121 grants / $1,020

42nd Annual Scientific meeting of the Australasian Society for Immunology, Melbourne Convention and Exhibition Centre, 2 - 6 December 2012$1,020

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Vicki Maltby
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1201000
Type Of FundingInternal
CategoryINTE
UONY
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Dr Vicki Maltby

Position

Research Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Emailvicki.e.maltby@newcastle.edu.au
Phone(02) 4042 0286
Fax(02) 4042 0031

Office

RoomHMRI 3 West
BuildingHMRI
LocationHMRI

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