Dr Saadallah Ramadan

Dr Saadallah Ramadan

Research Academic

Faculty of Health and Medicine (Medical Radiation Science)

Career Summary

Biography

Biography

Dr Ramadan is the HMRI Imaging Center Facility Manager, School of Health Sciences, Faculty of Health and Medicine. He received his PhD from the School of Chemistry, The University of Sydney in 2000. He spent two years studying red blood cells by NMR techniques, followed by studying the effect of non-steroidal anti-inflammatory drugs on rat stomach using NMR. He was then appointed as senior researcher at the Institute for Magnetic Resonance Research at Royal North Shore Hospital. In 2007, he moved to Boston, MA to take a position of Physicist at the Brigham and Women's Hospital, and became an Instructor in Radiology at Harvard Medical School. He was integrally involved in the development of MRI Research Policy at Brigham and Women’s Hospital. Technical interests include MRI/MRS pulse sequence development for Siemens (Syngo) platforms, where he worked on many different platforms. Spectroscopic as well as MRI diffusion-weighted sequences were developed for Syngo platforms. His research activities involve programming and evaluating novel MR imaging and spectroscopic techniques for investigation of human disease, as well as analysis and data post processing. Current focus areas include: breast, brain and prostate MR imaging and spectroscopy. Dr. Ramadan commenced a full-time position at the University of Newcastle in 2011.

Dr. Ramadan has commanded strong understanding of the technological issues that need to be addressed in order for MR spectroscopy (MRS) to become a viable tool in neurology, psychiatry, cancer and pain research, and for the implementation of MR spectroscopy as a clinical tool in vivo.

Dr. Ramadan has played a leading role in the development of magnetic resonance spectroscopy in vivo over the last decade. Of particular importance was the development of two dimensional MR spectroscopy for use in a routine clinical scanner and in an acceptable time of 11 minutes. This technology is now being transferred for worldwide use by our industrial partners. Dr. Ramadan’s role on the multidisciplinary teams is to successfully address various diagnostic questions for many organs by the development of new MR technology. Two such examples are the two-dimensional spectroscopy at 3 and 7T (Tesla).

The successful implementation of two-dimensional correlation (COSY) spectroscopy in human soleus muscle at high field of 7T is an example of recent cutting edge technology was this the first of its kind in human muscle as such a high field . This was a novel application where muscle tissue was characterized for the first time at the higher frequency. Relaxation time constants of all detectable metabolites were determined and full analyses of COSY spectra to confirm assignments were successfully performed.

7T 2D localized 1H L-COSY of human soleus muscle (data collected from voxel shown below). See Ramadan et al. J Magn Reson 2010;204:91-98 for assignments. Expansions reveal details in crowded spectral regions. The tCr methyl resonance at 3.02 ppm was used as an internal chemical shift reference. Horizontal (F2) and vertical (F1) axes have ppm units.

Representative T1 (above) and T2 (below) array of spectra acquired at 7T from a healthy volunteer. The creatine methyl peak at 3.02 ppm was used as an internal chemical shift reference.

Successfully implementing correlation spectroscopy in the brain in less than 11 minutes for Glioblastoma was another milestone for Dr. Ramadan. This took the 2D method into the clinical realm with a time that was acceptable for patient studies. This method, currently published online in Radiology, reports on biochemical markers in glioma and the healthy brain. This method has since been applied to disease and head injury, and information previously not available for inspection in the one dimensional spectrum has been recorded. This method shows clearly that the biochemistry is altering with each disease.