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Dr Brett Graham

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Anatomy)

Career Summary

Biography

I am an electrophysiologist and use both in vitro and in vivo preparations in my experiments. My in vivo work allows the study of nerve cell properties and responses to “natural” stimuli, only possible using an intact preparation (an approach I pioneered during my PhD). My in vitro work permits detailed study of synaptic and intrinsic membrane properties in nerve cells using spinal cord or brain slice preparations. My in vitro studies also allows single channel analysis of individual receptor properties. All this work has been undertaken in mice so I can take advantage of the availability of mutant and transgenic animals for analyzing the role of specific receptor types (e.g. I have studied glycine receptor function in the mutant mice Spastic, Spasmodic, and Oscillator) or the properties of specific nerve cell types (e.g. my more recent work characterizing green fluorescent protein-expressing nerve cells in the spinal cords of transgenic mice). Because of this broad expertise I was invited to join the teaching faculty of the Australian Course in Advance Neuroscience (ACAN) in 2011. ACAN is recognized as “the pre-eminent course in the Asia-Pacific region for young scientists who would like to become experts in cellular neurophysiology”. Similarly my research expertise and standing in pain research has recently been acknowledged with an invitation for me to organize a topical workshop for the 2012 International Association for the Study of Pain World Congress (held biennially). This prestigious meeting brings together over 6,000 of the world’s leading professionals in the field of pain research and treatment to discuss current progress and new perspectives on pain management.

Research Expertise
My research expertise is based around electrophysiological techniques that range from real-time monitoring of conformational changes in cell membrane associated protiens (single channel recording) through to systems-level analysis of neuronal processing (in vivo recordings). I have pioneered the approach of making patch-clamp recordings in mouse spinal cord under in vivo conditions to analise pain processing mechanisms in the whole animal. I also routinely make in vitro recordings for mouse spinal cord slices, allowing pharmacological analyses of siganl processing in the dorsal horn.

Teaching Expertise
I provide teaching into a number of courses where the topics covered can be broadly grouped as relating to anatomy and physiology. I coordinate a course in Exercise Physiology and act as the sole lecturer in that course. Other areas of particular expertise include CNS function, synaptic transmission and pain.

Administrative Expertise
My position is research-based.

Collaborations
Since establishing my laboratory at Newcastle I have developed research projects built around three research themes. Theme 1: Targeted study of specific spinal nerve cell types involved in pain processing Theme 2: Immune and nervous system interactions in painful inflammatory conditions Theme 3: Drug-induced synaptic plasticity in the lateral hypothalamus Each theme has attracted funding in its own right and I have established several local (Newcastle), national (Sydney, Adelaide), and international (Glasgow, Singapore) collaborations with researchers who have expertise in other, complimentary disciplines.


Qualifications

  • Doctor of Philosophy, University of Newcastle
  • Bachelor of Biomedical Sciences, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Biomedical Science
  • Neurophysiology
  • Neuroscience
  • Pain
  • Spinal cord
  • Synaptic transmission

Fields of Research

CodeDescriptionPercentage
110999Neurosciences not elsewhere classified35
111699Medical Physiology not elsewhere classified55
170299Cognitive Sciences not elsewhere classified10

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2008 - 1/12/2011FellowNHMRC (National Health & Medical Research Council)

Membership

DatesTitleOrganisation / Department
1/01/2001 - Membership - Australian Neuroscience Society (ANS)Australian Neuroscience Society (ANS)
Australia
1/01/2001 - Membership - International Association for the Study of Pain (IASP)IASP International Association for the Study of Pain
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

YearCitationAltmetricsLink
2012Graham BA, Callister RJ, 'Pain', The Mouse Nervous System, Academic Press, San Diego 589-606 (2012) [B1]
CitationsScopus - 1
Co-authorsRobert Callister

Journal article (34 outputs)

YearCitationAltmetricsLink
2015Callister RJ, Graham BA, 'Spicing up the gabapentionoids: Facilitating gabapentin entry in spinal pain circuits', NEUROSCIENCE LETTERS, 584 395-396 (2015)
DOI10.1016/j.neulet.2014.08.039Author URL
Co-authorsRobert Callister
2015Callister RJ, Graham BA, 'Spicing up the gabapentionoids: Facilitating gabapentin entry in spinal pain circuits', Neuroscience Letters, 584 395-396 (2015)
DOI10.1016/j.neulet.2014.08.039
Co-authorsRobert Callister
2015Tadros MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Properties of sodium currents in neonatal and young adult mouse superficial dorsal horn neurons', Molecular Pain, 11 (2015)

Background: Superficial dorsal horn (SDH) neurons process nociceptive information and their excitability is partly determined by the properties of voltage-gated sodium channels. Recently, we showed the excitability and action potential properties of mouse SDH neurons change markedly during early postnatal development. Here we compare sodium currents generated in neonate (P0-5) and young adult (=P21) SDH neurons. Results: Whole cell recordings were obtained from lumbar SDH neurons in transverse spinal cord slices (CsF internal, 32°C). Fast activating and inactivating TTX-sensitive inward currents were evoked by depolarization from a holding potential of 100mV. Poorly clamped currents, based on a deflection in the IV relationship at potentials between 60 and 50mV, were not accepted for analysis. Current density and decay time increased significantly between the first and third weeks of postnatal development, whereas time to peak was similar at both ages. This was accompanied by more subtle changes in activation range and steady state inactivation. Recovery from inactivation was slower and TTX-sensitivity was reduced in young adult neurons. Conclusions: Our study suggests sodium channel expression changes markedly during early postnatal development in mouse SDH neurons. The methods employed in this study can now be applied to future investigations of spinal cord sodium channel plasticity in murine pain models.

DOI10.1186/s12990-015-0014-5
Co-authorsRobert Callister
2014Stuart DG, Schaefer AT, Massion J, Graham BA, Callister RJ, 'Pioneers in CNS inhibition: 1. Ivan M. Sechenov, the first to clearly demonstrate inhibition arising in the brain', Brain Research, 1548 20-48 (2014)
DOI10.1016/j.brainres.2013.12.006
Co-authorsRobert Callister
2014Stuart DG, Schaefer AT, Massion J, Graham BA, Callister RJ, 'Pioneers in CNS inhibition: 1. Ivan M. Sechenov, the first to clearly demonstrate inhibition arising in the brain', Brain Research, 1548 20-48 (2014) [C1]

This article reviews the contributions of Ivan Michailovich Sechenov [1829-1905] to the neurophysiological concept of central inhibition. He first studied this concept in the frog and on himself. Later his trainees extended the study of central inhibition to other mammalian species. Outside his own country, Sechenov is better known for his prescient contributions to physiological psychology. In Russia, however, he is also revered as "the father of Russian physiology," because of his contributions to neurophysiology and other aspects of physiology including blood gases and respiration, the physiology and biomechanics of movement, and general physiology concepts that appeared in his textbooks and later works he helped translate from largely German sources. After graduation from Moscow University Medical School in 1856 he spent 31/2 years in Germany and Austria where he attended lectures and conducted research under the direction of several prominent physiologists and biochemists. In his subsequent academic career he held positions at universities in St. Petersburg (1860-1870; 1876-1888), Odessa (1871-1876) and Moscow (1890-1905). From 1860 onwards he was acclaimed as a physiologist in academic circles. He was also well known in Russian society for his public lectures on physiology and his views on physiological psychology. The latter resulted in him being branded "politically unreliable" by the tsarist bureaucracy from 1863 onwards. Sechenov's first (1862) study on central inhibition remains his most memorable. He delayed the withdrawal of a frog's foot from a weak acid solution by chemical or electrical stimulation of selected parts of the central nervous system. He also noted similar effects on his own hand during co-activation of other sensory inputs by tickling or teeth gnashing. © 2013 Elsevier B.V. All rights reserved.

DOI10.1016/j.brainres.2013.12.006
CitationsScopus - 1
Co-authorsRobert Callister
2014Tadros MA, Farrell KE, Schofield PR, Brichta AM, Graham BA, Fuglevand AJ, Callister RJ, 'Intrinsic and synaptic homeostatic plasticity in motoneurons from mice with glycine receptor mutations', Journal of Neurophysiology, 111 1487-1498 (2014) [C1]

Inhibitory synaptic inputs to hypoglossal motoneurons (HMs) are important for modulating excitability in brainstem circuits. Here we ask whether reduced inhibition, as occurs in three murine mutants with distinct naturally occurring mutations in the glycine receptor (GlyR), leads to intrinsic and/or synaptic homeostatic plasticity. Whole cell recordings were obtained from HMs in transverse brainstem slices from wild-type (wt), spasmodic (spd), spastic (spa), and oscillator (ot) mice (C57Bl/6, approximately postnatal day 21). Passive and action potential (AP) properties in spd and ot HMs were similar to wt. In contrast, spa HMs had lower input resistances, more depolarized resting membrane potentials, higher rheobase currents, smaller AP amplitudes, and slower afterhyperpolarization current decay times. The excitability of HMs, assessed by "gain" in injected current/firing-frequency plots, was similar in all strains whereas the incidence of rebound spiking was increased in spd. The difference between recruitment and derecruitment current (i.e., ¿I) for AP discharge during ramp current injection was more negative in spa and ot. GABAA miniature inhibitory postsynaptic current (mIPSC) amplitude was increased in spa and ot but not spd, suggesting diminished glycinergic drive leads to compensatory adjustments in the other major fast inhibitory synaptic transmitter system in these mutants. Overall, our data suggest long-term reduction in glycinergic drive to HMs results in changes in intrinsic and synaptic properties that are consistent with homeostatic plasticity in spa and ot but not in spd. We propose such plasticity is an attempt to stabilize HM output, which succeeds in spa but fails in ot. © 2014 the American Physiological Society.

DOI10.1152/jn.00728.2013
Co-authorsRobert Callister, Alan Brichta
2014Farrell KE, Keely S, Graham BA, Callister R, Callister RJ, 'A Systematic Review of the Evidence for Central Nervous System Plasticity in Animal Models of Inflammatory-mediated Gastrointestinal Pain', INFLAMMATORY BOWEL DISEASES, 20 176-195 (2014) [C1]
DOI10.1097/01.MIB.0000437499.52922.b1Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsRobin Callister, Simon Keely, Robert Callister
2014Yeoh JW, Campbell EJ, James MH, Graham BA, Dayas CV, 'Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls.', Front Neurosci, 8 36 (2014) [C1]
DOI10.3389/fnins.2014.00036Author URL
CitationsScopus - 11Web of Science - 11
Co-authorsChristopher Dayas
2014Yeoh JW, James MH, Graham BA, Dayas CV, 'Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART)', FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 8 (2014) [C1]
DOI10.3389/fnbeh.2014.00280Author URL
CitationsWeb of Science - 1
Co-authorsChristopher Dayas
2014Harris BM, Hughes DI, Bolton PS, Tadros MA, Callister RJ, Graham BA, 'Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation', MOLECULAR PAIN, 10 (2014) [C1]
DOI10.1186/1744-8069-10-25Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsRobert Callister, Philip Bolton
2014Smith KM, Madden JF, Callister RJ, Hughes DI, Graham BA, 'The search for novel analgesics: re-examining spinal cord circuits with new tools.', Front Pharmacol, 5 22 (2014) [C1]
DOI10.3389/fphar.2014.00022Author URL
CitationsScopus - 1Web of Science - 2
Co-authorsRobert Callister
2013Hughes DI, Boyle KA, Kinnon CM, Bilsland C, Quayle JA, Callister RJ, Graham BA, 'HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus', Neuroscience, 237 7-18 (2013) [C1]

Hyperpolarisation-activated (Ih) currents are considered important for dendritic integration, synaptic transmission, setting membrane potential and rhythmic action potential (AP) discharge in neurons of the central nervous system. Hyperpolarisation-activated cyclic nucleotide-gated (HCN) channels underlie these currents and are composed of homo- and hetero-tetramers of HCN channel subunits (HCN1-4), which confer distinct biophysical properties on the channel. Despite understanding the structure-function relationships of HCN channels with different subunit stoichiometry, our knowledge of their expression in defined neuronal populations remains limited. Recently, we have shown that HCN subunit expression is a feature of a specific population of dorsal horn interneurons that exhibit high-frequency AP discharge. Here we expand on this observation and use neuroanatomical markers to first identify well-characterised neuronal populations in the lumbar spinal cord and hippocampus and subsequently determine whether HCN4 expression correlates with high-frequency AP discharge in these populations. In the spinal cord, HCN4 is expressed in several putative inhibitory interneuron populations including parvalbumin (PV)-expressing islet cells (84.1%; SD: ±2.87), in addition to all putative Renshaw cells and Ia inhibitory interneurons. Similarly, virtually all PV-expressing cells in the hippocampal CA1 subfield (93.5%; ±3.40) and the dentate gyrus (90.9%; ±6.38) also express HCN4. This HCN4 expression profile in inhibitory interneurons mirrors both the prevalence of Ih sub-threshold currents and high-frequency AP discharge. Our findings indicate that HCN4 subunits are expressed in several populations of spinal and hippocampal interneurons, which are known to express both Ih sub-threshold currents and exhibit high-frequency AP discharge. As HCN channel function plays a critical role in pain perception, learning and memory, and sleep as well as the pathogenesis of several neurological diseases, these findings provide important insights into the identity and neurochemical status of cells that could underlie such conditions. © 2013 IBRO.

DOI10.1016/j.neuroscience.2013.01.028
CitationsScopus - 6Web of Science - 5
Co-authorsRobert Callister
2012James MH, Yeoh JW, Graham B, Dayas C, 'Insights for Developing Pharmacological Treatments for Psychostimulant Relapse Targeting Hypothalamic Peptide Systems.', Journal of Addiction Research and Therapy, 01 1-14 (2012)
Co-authorsChristopher Dayas
2012Tadros MA, Harris B, Anderson WB, Brichta AM, Graham BA, Callister RJ, 'Are all spinal segments equal: Intrinsic membrane properties of superficial dorsal horn neurons in the developing and mature mouse spinal cord', Journal of Physiology, 590 2409-2425 (2012) [C1]
CitationsScopus - 6Web of Science - 5
Co-authorsAlan Brichta, Robert Callister
2012Yeoh JW, James MH, Jobling P, Bains JS, Graham BA, Dayas CV, 'Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus', Journal of Physiology, 590 3677-3689 (2012) [C1]
CitationsScopus - 11Web of Science - 10
Co-authorsPhillip Jobling, Christopher Dayas
2012Hughes DI, Sikander S, Kinnon CM, Boyle KA, Watanabe M, Callister RJ, Graham BA, 'Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: A likely source of axo-axonic inputs in the mouse spinal dorsal horn', Journal of Physiology, 590 3927-3951 (2012) [C1]
CitationsScopus - 24Web of Science - 23
Co-authorsRobert Callister
2011Graham BA, Tadros MA, Schofield PR, Callister RJ, 'Probing glycine receptor stoichiometry in superficial dorsal horn neurones using the spasmodic mouse', Journal of Physiology, 589 2459-2474 (2011) [C1]
DOI10.1113/jphysiol.2011.206326
CitationsScopus - 11Web of Science - 11
Co-authorsRobert Callister
2011Flynn JR, Graham BA, Galea MP, Callister RJ, 'The role of propriospinal interneurons in recovery from spinal cord injury', Neuropharmacology, 60 809-822 (2011) [C1]
DOI10.1016/j.neuropharm.2011.01.016
CitationsScopus - 23Web of Science - 20
Co-authorsRobert Callister
2011Flynn JR, Brichta AM, Galea MP, Callister RJ, Graham BA, 'A horizontal slice preparation for examining the functional connectivity of dorsal column fibres in mouse spinal cord', Journal of Neuroscience Methods, 200 113-120 (2011) [C1]
DOI10.1016/j.jneumeth.2011.06.017
CitationsScopus - 4Web of Science - 5
Co-authorsAlan Brichta, Robert Callister
2010Callister RJ, Graham BA, 'Early history of glycine receptor biology in mammalian spinal cord circuits', Frontiers in Molecular Neuroscience, 3 1-13 (2010) [C1]
DOI10.3389/fnmol.2010.00013
CitationsScopus - 9
Co-authorsRobert Callister
2010Jobling P, Graham BA, Brichta AM, Callister RJ, 'Cervix stimulation evokes predominantly subthreshold synaptic responses in mouse thoracolumbar and lumbosacral superficial dorsal horn neurons', Journal of Sexual Medicine, 7 2068-2076 (2010) [C1]
DOI10.1111/j.1743-6109.2010.01768.x
CitationsScopus - 4Web of Science - 4
Co-authorsRobert Callister, Alan Brichta, Phillip Jobling
2010De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
DOI10.1016/j.jneumeth.2010.03.029
CitationsScopus - 6Web of Science - 6
Co-authorsAlan Brichta, Rebecca Lim, Dirk Vanhelden, Robert Callister
2010Graham BA, Clausen PD, Bolton PS, 'A descriptive study of the force and displacement profiles of the toggle-recoil spinal manipulative procedure (adjustment) as performed by chiropractors', Manual Therapy, 15 74-79 (2010) [C1]
DOI10.1016/j.math.2009.07.003
CitationsScopus - 10Web of Science - 7
Co-authorsPhilip Clausen, Philip Bolton
2009Anderson WB, Graham BA, Beveridge NJ, Tooney PA, Brichta AM, Callister RJ, 'Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons', Molecular Pain, 5 1-16 (2009) [C1]
DOI10.1186/1744-8069-5-65
CitationsScopus - 8Web of Science - 7
Co-authorsRobert Callister, Alan Brichta, Paul Tooney
2009Tadros MA, Graham BA, Brichta AM, Callister RJ, 'Evidence for a critical period in the development of excitability and potassium currents in mouse lumbar superficial dorsal horn neurons', Journal of Neurophysiology, 101 1800-1812 (2009) [C1]
DOI10.1152/jn.90755.2008
CitationsScopus - 25Web of Science - 24
Co-authorsRobert Callister, Alan Brichta
2008Graham BA, Brichta AM, Callister RJ, 'Recording temperature affects the excitability of mouse superficial dorsal horn neurons, in vitro', Journal of Neurophysiology, 99 2048-2059 (2008) [C1]
DOI10.1152/jn.01176.2007
CitationsScopus - 19Web of Science - 20
Co-authorsAlan Brichta, Robert Callister
2007Graham BA, Brichta AM, Callister RJ, 'Moving from an averaged to specific view of spinal cord pain processing circuits', Journal of Neurophysiology, 98 1057-1063 (2007) [C1]
DOI10.1152/jn.00581.2007
CitationsScopus - 57Web of Science - 51
Co-authorsAlan Brichta, Robert Callister
2007Graham BA, Brichta AM, Callister RJ, 'Pinch-current injection defines two discharge profiles in mouse superficial dorsal horn neurones, in vitro', Journal of Physiology, 578 787-798 (2007) [C1]
DOI10.1113/jphysiol.2006.123349
CitationsScopus - 19Web of Science - 18
Co-authorsAlan Brichta, Robert Callister
2007Graham BA, Brichta AM, Schofield PR, Callister RJ, 'Altered potassium channel function in the superficial dorsal horn of the spastic mouse', Journal of Physiology, 584 121-136 (2007) [C1]
DOI10.1113/jphysiol.2007.138198
CitationsScopus - 18Web of Science - 16
Co-authorsAlan Brichta, Robert Callister
2006Graham BA, Schofield PR, Sah P, Margrie TW, Callister RJ, 'Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants, spastic, spasmodic, and oscillator', Journal of Neuroscience, 26 4880-4890 (2006) [C1]
DOI10.1523/JNEUROSCI.3991-05.2006
CitationsScopus - 27Web of Science - 28
Co-authorsRobert Callister
2004Graham BA, Brichta AM, Callister RJ, 'In vivo responses of mouse superficial dorsal horn neurones to both current injection and peripheral cutaneous stimulation', Journal of Physiology, 561.3 749-763 (2004) [C1]
DOI10.1113/jphysiol.2004.072645
CitationsScopus - 41Web of Science - 39
Co-authorsAlan Brichta, Robert Callister
2004Graham BA, Brichta AM, Callister RJ, 'An in vivo mouse spinal cord preparation for patch-clamp analysis of nociceptive processing', Journal of Neuroscience Methods, 136 221-228 (2004) [C1]
DOI10.1016/j.jneumeth.2004.01.014
CitationsScopus - 16Web of Science - 14
Co-authorsAlan Brichta, Robert Callister
2003Graham BA, Schofield PR, Sah P, Callister RJ, 'Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice', The Journal of Physiology, 551.3 905-916 (2003) [C1]
DOI10.1113/jphysiol.2003.049064
CitationsScopus - 34Web of Science - 31
Co-authorsRobert Callister
2002Graham BA, Schofield P, Sah P, Callister RJ, 'GABAAergic and glycinergic synaptic transmission in superficial dorsal horn neurones of wild type, spastic and oscillator mice', Proceedings of the Australian Neuroscience Society, 22:94 n/a (2002) [C3]
Co-authorsRobert Callister
Show 31 more journal articles

Conference (25 outputs)

YearCitationAltmetricsLink
2014Farrell KE, Graham BA, Keely S, Callister RJ, 'Understanding the mechanisms underlying chronic pain in IBD: A new method for studying visceral inputs from the gastrointestinal tract', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsSimon Keely, Robert Callister
2014Wellings TP, Graham BA, Camp AJ, Callister RJ, Brichta AM, Lim R, 'Calcium binding proteins subdivide medial vestibular nucleus neurons', Journal of Vestibular Research: Equilibrium and Orientation: an international journal of experimental and clinical vestibular science, Buenos Aires, Argentina (2014) [E3]
DOI10.3233/VES-140517
Co-authorsRobert Callister, Alan Brichta, Rebecca Lim
2013Wellings TP, Callister RJ, Graham BA, Brichta AM, Lim R, 'Sensing balance: the role of central vestibular nuclei', University of Western Sydney Medical School, University of Western Sydney (2013) [E3]
Co-authorsRobert Callister, Alan Brichta, Rebecca Lim
2012Flynn JR, Callister RJ, Graham BA, 'Electrophysiological properties of identified long descending propriospinal neurons in mice', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsRobert Callister
2012Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsRebecca Lim, Alan Brichta, Robert Callister
2012Jobling P, Madden JF, Graham BA, 'Whole cell patch clamp recordings from muscle spindle afferent neurons in intact dorsal root ganglia isolated from mouse', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsPhillip Jobling
2012Tadros MA, Jack R, Lim R, Graham BA, Brichta AM, Hughes DI, Callister RJ, 'Sensorimotor processing in the spinal cord of the developing human fetus', Society for Neuroscience, New Orleans, USA (2012)
Co-authorsRebecca Lim, Robert Callister, Alan Brichta
2012Farrell KE, Keely S, Graham BA, Minahan KL, Madden JF, Callister RJ, 'Spinal cord signalling in a mouse model of inflammatory bowel disease', Journal of Gastroenterology and Hepatology, Adelaide, SA (2012) [E3]
Co-authorsSimon Keely, Robert Callister
2011Tadros MA, Lim R, Graham BA, Hughes DI, Brichta AM, Callister RJ, 'Excitability of human ventral horn neurons during early foetal development', Poster Abstracts. Australian Neuroscience Society Annual Meeting, Auckland, NZ (2011) [E3]
Co-authorsAlan Brichta, Robert Callister, Rebecca Lim
2011Jobling P, Smith K, Madden J, Hickey LR, Graham BA, 'Characterisation of pain behaviour, spinal neurochemistry and glial populations in a mouse antigen-induced arthritis model', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
Co-authorsPhillip Jobling
2011Graham BA, Sah P, Brichta AM, Callister RJ, Hughes DI, 'Neuroanatomical and neurochemical features of parvalbumin-expressing neurons in the mouse spinal dorsal horn', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
Co-authorsRobert Callister, Alan Brichta
2010Callister RJ, Walsh MA, Harris BM, Anderson WB, Brichta AM, Graham BA, 'Segmental and developmental differences in the excitability of mouse superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authorsAlan Brichta, Robert Callister
2010Walsh MA, Farrell KE, Graham BA, Brichta AM, Callister RJ, 'Sodium current properties differ in neonate and adult superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authorsAlan Brichta, Robert Callister
2010Harris BM, Graham BA, Bolton PS, Brichta AM, Callister RJ, 'Influence of acute neck muscle inflammation on the excitability of superficial dorsal horn neurons', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authorsPhilip Bolton, Alan Brichta, Robert Callister
2010Hughes DI, Sah P, Callister RJ, Graham BA, 'Neuroanatomical and electrophysiological features of parvalbumin-expressing neurons in the rodent spinal dorsal horn', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authorsRobert Callister
2010Graham BA, Hughes DI, Lim R, Sah P, Brichta AM, Callister RJ, 'Characterization of calretinin expressing interneurons in the superficial dorsal horn of the mouse spinal cord', 13th World Congress on Pain: Abstracts, Montreal, QC (2010) [E3]
Co-authorsRobert Callister, Alan Brichta, Rebecca Lim
2009Graham BA, Schofield PR, Callister RJ, 'Glycine receptor mediated synaptic transmission in the superficial dorsal horn of Spasmodic mice', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsRobert Callister
2009Tadros MA, Anderson WB, Graham BA, Callister RJ, 'Responses to current injection differ between mouse cervical, thoracic and lumbar superficial dorsal horn neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsRobert Callister
2008Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch clamp recording of synaptic events evoked in superficial dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsAlan Brichta, Robert Callister, Phillip Jobling
2008Callister RJ, Brichta AM, Graham BA, 'Beyond the dorsal horn: The use of animal models to discover new sites for pain therapy', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authorsRobert Callister, Alan Brichta
2006Anderson WB, Graham BA, Jobling P, Lim R, Brichta AM, Callister RJ, 'Glycine receptor diversity in the dorsal horn of the mouse spinal cord', Society for Neuroscience, Atlanta, GA (2006) [E3]
Co-authorsPhillip Jobling, Alan Brichta, Rebecca Lim, Robert Callister
2006Jobling P, Graham BA, Brichta AM, Callister RJ, 'In vivo patch-clamp recording of subthreshold synaptic events evoked in dorsal horn neurons after stimulation of the female reproductive tract in the mouse', Society for Neuroscience, Atlanta, Georgia (2006) [E3]
Co-authorsRobert Callister, Phillip Jobling, Alan Brichta
2006Walsh MA, Graham BA, Brichta AM, Callister RJ, 'Postnatal development of electrophysiological properties in mouse supeficial dorsal horn neurones', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authorsAlan Brichta, Robert Callister
2005Graham BA, Brichta AM, Callister RJ, 'Effect of Temperature on the Discharge Properties of Mouse Superficial Dorsal Horn Neurons', Proceedings of the Australian Neuroscience Society, Perth (2005) [E3]
Co-authorsAlan Brichta, Robert Callister
2005Callister RJ, Graham BA, Brichta AM, 'In Vivo Responses of Mouse Spinal Neurones to Electrical and Functionally-Relevant Stimulation', Proceedings of the Australian Neuroscience Society Conference, Perth (2005) [E3]
Co-authorsAlan Brichta, Robert Callister
Show 22 more conferences
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Grants and Funding

Summary

Number of grants25
Total funding$3,008,035

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $22,000

Electrophysiology rig for the study of schizophrenia-related changes in white matter neurons after maternal infection$22,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamAssociate Professor Paul Tooney, Doctor Phil Jobling, Doctor Brett Graham, Professor Deborah Hodgson, Emeritus Professor Patricia Michie, Doctor Lauren Harms
SchemeResearch Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400999
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20143 grants / $1,001,022

Spinal processing of sensory signals from the gut$536,226

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Robert Callister, Doctor Simon Keely, Doctor Brett Graham, Professor Alan Brichta, Dr David Hughes
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300361
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Microglia as primary drivers of stress-induced changes in neuronal connectivity$460,037

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Frederick Walker, Doctor Brett Graham
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300330
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Neurobiological Investigation of Interstitial White Matter Neurons in a Maternal Infection Activation Model of Schizophrenia$4,759

Funding body: Australian Rotary Health

Funding bodyAustralian Rotary Health
Project TeamAssociate Professor Paul Tooney, Doctor Phil Jobling, Doctor Brett Graham
SchemeIan Scott Scholarship
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301103
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20131 grants / $466,044

The role of presynaptic inhibition in neuropathic pain$466,044

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Brett Graham, Professor Robert Callister, Dr David Hughes, Professor George Augustine
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1200088
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20122 grants / $22,000

Characterizing psychostimulant-induced synaptic plasticity in the hypothalamus$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas, Doctor Brett Graham
SchemeNear Miss Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200677
Type Of FundingInternal
CategoryINTE
UONY

14th World Congress on Pain (International Association for the Study of Pain), Milan Italy, 26-31 August 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Brett Graham
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200544
Type Of FundingInternal
CategoryINTE
UONY

20111 grants / $20,000

How do the immune and nervous systems interact in arthritis?$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Phil Jobling, Doctor Brett Graham
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000987
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20106 grants / $1,038,803

Spinal mechanism underlying arthritic joint pain$416,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Brett Graham
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0190192
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Characterising the synaptic physiology of orexin neurons in response to cocaine: Implications for drug relapse$21,303

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamDoctor Chris Dayas, Doctor Brett Graham
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900151
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

13th World Congress on Pain, Montreal, Canada, 29 August - 2 September 2010$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Brett Graham
SchemeTravel Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000533
Type Of FundingInternal
CategoryINTE
UONY

20094 grants / $64,644

Neurometer CPT/C$28,435

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Philip Bolton, Professor Robert Callister, Professor Alan Brichta, Professor Robin Callister, Doctor Brett Graham, Doctor Phil Jobling
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189845
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189842
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Spinal mechanisms of chronic pain in arthritis$15,000

Funding body: Arthritis Australia

Funding bodyArthritis Australia
Project TeamDoctor Brett Graham
SchemeGrant-In-Aid
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189342
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

New Staff Grant 2009$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Brett Graham
SchemeNew Staff Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189912
Type Of FundingInternal
CategoryINTE
UONY

20082 grants / $299,000

Mechanisms underlying vestibular cortical representation$279,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Brett Graham
SchemeEarly Career Fellowships
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188073
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Leica VT2100S Vibrating Microtome$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alan Brichta, Professor Robert Callister, Professor Dirk Van Helden, Associate Professor Philip Bolton, Doctor Rebecca Lim, Doctor Brett Graham, Dr Marcus Howlett, Doctor Angela McPherson, Doctor Mohammad Imtiaz, Doctor Ramatis De Oliveira, Mr Wayne Anderson, Mr Matthew Walsh
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188540
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20074 grants / $66,182

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188196
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Identifying new spinal cord targets for pain management.$14,252

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Brett Graham, Professor Robert Callister
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187234
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Identifying new spinal cord targets for pain management$14,252

Funding body: Hunter Medical Research Institute (HMRI)

Funding bodyHunter Medical Research Institute (HMRI)
Project Team
SchemeHMRI Brain and Mental Health Research Program
RoleLead
Funding Start2007
Funding Finish2007
GNo
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Developing a rodent model to study neck pain$7,678

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Robert Callister, Associate Professor Philip Bolton, Professor Alan Brichta, Doctor Brett Graham
SchemePilot Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187879
Type Of FundingInternal
CategoryINTE
UONY

20051 grants / $8,340

Attend the Society for Neurosciences 35th Annual Meeting in Washington DC USA 12 to 16 November 2005 & visit labs of Prof Maria Fitzgerald & Dr Troy Margrie University College London UK$8,340

Funding body: NSW Ministry for Science and Medical Research

Funding bodyNSW Ministry for Science and Medical Research
Project TeamDoctor Brett Graham
SchemeSpinal Cord Injury & Other Neurological Conditions Travel Scholarships
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185447
Type Of FundingNot Known
CategoryUNKN
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Optogenetic Dissection of Hypothalamic Brain Circuitry and its Implications for Conditions of Motivated Behaviour
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2014The Sinoatrial Node Pacemaker in Health and Disease
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2014Investigation of White Matter Neurons in the Maternal Immune Activation Model of Schizophrenia
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013The Role of Calretinin Positive Interneurons in Spinal Sensory Coding
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2011Spinal Cord Signalling in a Mouse Model of IBD
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2010Drug-Induced Changes to the Lateral Hypothalamic Orexin Circuits and Downstream Projection Targets
Human Biology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Electrophysiological Investigation of Spinal Cord Injury and Characterisation of Propriospinal Neurons
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012The Effect of Neck Muscle Inflammation on Neuronal Excitability in the Dorsal Horn of the Spinal Cord
Human Biology, Faculty of Health and Medicine
Co-Supervisor
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News

microscope

Microscope to shed light on mental health

April 30, 2015

A laser-equipped microscope that gives brain researchers unparalleled insight into mental illness has just been installed at the University of Newcastle.

Dr Brett Graham

Position

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Anatomy

Contact Details

Emailbrett.graham@newcastle.edu.au
Phone(02) 4921 5397
Fax(02) 4921 7906
LinkUoN Blogs

Office

RoomMS411
BuildingMedical Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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