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Dr Liz Holliday

Conjoint Associate Professor

School of Medicine and Public Health

Career Summary

Biography

Elizabeth (Liz) Holliday is a genetic statistician with training in molecular bioscience (BSc Hons I - 2003), genetic epidemiology (PhD - 2008) and statistics (MSc - 2012). She is a Senior Statistician in the Clinical Research Design, IT and Statistical Support (CReDITSS) Unit at the Hunter Medical Research Institute. In this role she provides epidemiological and statistical support and advice to clinical researchers.

Her research interests include statistical genetics, causal inference in observational epidemiology and longitudinal data analyses.

Liz has published over 70 journal articles and book chapters/sections. She has also received a number of nationally competive grants and awards for her research.

Research Expertise
Liz has research expertise in biostatistics, genetic epidemiology, human disease mapping, and traditional epidemiology. She has substantial experience in the design and conduct of genome-wide association studies of various complex diseases, particularly stroke, kidney disease, and eye disorders such as macular degeneration. She also has experience with more classical epidemiological research, including case-control and prospective cohort observational studies.

Teaching Expertise
2011-2012: Course Coordinator for BIOS6910 (Biostatistics A).

Collaborations
Liz collaborates with a variety of international genetics consortia including: - The International Stroke Genetics Consortium (ISGC). From 2012-2014 she chaired the central analysis group for the ISGC. - Cohorts for Heart and Aging Research In Genomic Epidemiology (CHARGE) consortium - The Chronic Kidney Disease Genetics (CKDGen) consortium - The Genetic Investigation of ANthropometric Traits (GIANT) consortium - the Social Science Genetic Association Consortium (SSGAC) Within Australia, Liz collaborates with the Australian Stroke Genetics Consortium (ASGC), the Blue Mountains Eye Study (BMES), the Cardiovascular Research Network (CVRN) and the Queensland Institute of Medical Research (QIMR), among others.

Qualifications

  • PhD, University of Queensland
  • Bachelor of Science (Honours), University of Queensland
  • Master of Science (Statistics), University of Queensland

Keywords

  • Biostatistics
  • Genetic association
  • Genetic epidemiology
  • Statistical genetics

Fields of Research

Code Description Percentage
010402 Biostatistics 35
060408 Genomics 30
060412 Quantitative Genetics (incl. Disease and Trait Mapping Genetics) 35

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/10/2010 -  NHMRC Early Career Research Fellow University of Newcastle
School of Medicine and Public Health
Australia
1/01/2010 - 1/05/2014 Fellowship University of Newcastle
School of Medicine and Public Health
Australia
1/01/2010 -  Membership - International Stroke Genetics Consortium International Stroke Genetics Consortium
Australia
1/09/2009 - 1/09/2010 Gladys M Brawn Memorial Postdoctoral Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/03/2007 - 1/09/2009 Research Scientist Queensland Government - Department of Health
Centre for Mental Health
Australia

Awards

Honours

Year Award
2013 High Flyers Think Tank
Australian Academy of Science
2013 High Flyers Think Tank
Australian Academy of Science
2012 Star Graduate
Unknown
2012 Star Graduate
Unknown
2002 Dean's Commendation for High Achievement in Bachelor of Science
University of Queensland
2002 Dean's Commendation for High Achievement in Bachelor of Science
University of Queensland

Research Award

Year Award
2013 Career Development Award
International Stroke Genetics Consortium
2013 Career Development Award
International Stroke Genetics Consortium
2011 Best Platform (Oral) Presentation
Unknown
2011 Peter Bladin New Investigator Award
Stroke Society of Australasia
2011 Young Investigator Travel Award
Stroke Society of Australasia
2011 Education Prize
Hunter Medical Research Institute
2011 Best Platform (Oral) Presentation
Unknown
2011 Peter Bladin New Investigator Award
Stroke Society of Australasia
2011 Young Investigator Travel Award
Stroke Society of Australasia
2011 Education Prize
Hunter Medical Research Institute
2007 Best Student Poster Presentation
Unknown
2007 Best Student Poster Presentation
Unknown
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (5 outputs)

Year Citation Altmetrics Link
2015 Riveros C, Vimieiro R, Holliday EG, Oldmeadow C, Wang JJ, Mitchell P, et al., 'Identification of genome-wide snp¿snp and snp¿clinical boolean interactions in age-related macular degeneration', , Humana Press Inc. (2015)

We propose here a methodology to uncover modularities in the network of SNP¿SNP interactions most associated with disease. We start by computing all possible Boolean binary SNP i... [more]

We propose here a methodology to uncover modularities in the network of SNP¿SNP interactions most associated with disease. We start by computing all possible Boolean binary SNP interactions across the whole genome. By constructing a weighted graph of the most relevant interactions and via a combinatorial optimization approach, we fnd the most highly interconnected SNPs. We show that the method can be easily extended to fnd SNP/environment interactions. Using a modestly sized GWAS dataset of age-related macular degeneration (AMD), we identify a group of only 19 SNPs, which include those in previously reported regions associated to AMD. We also uncover a larger set of loci pointing to a matrix of key processes and functions that are affected. The proposed integrative methodology extends and overlaps traditional statistical analysis in a natural way. Combinatorial optimization techniques allow us to fnd the kernel of the most central interactions, complementing current methods of GWAS analysis and also enhancing the search for gene¿environment interaction.

DOI 10.1007/978-1-4939-2155-3_12
Co-authors John Attia, Rodney Scott, Christopher Oldmeadow, Pablo Moscato
2015 Riveros C, Vimieiro R, Holliday EG, Oldmeadow C, Wang JJ, Mitchell P, et al., 'Identification of genome-wide SNP-SNP and SNP-clinical Boolean interactions in Age-related Macular Degeneration', Epistasis: Methods and Protocols, Springer, New York 217-255 (2015)
DOI 10.1007/978-1-4939-2155-3_12
Co-authors Pablo Moscato, Rodney Scott, Christopher Oldmeadow, John Attia
2014 Holliday EG, 'Sampling Error', Encyclopedia of Quality of Life and Well-Being Research, Springer, Dordrecht, Netherlands 5643-5645 (2014) [D2]
DOI 10.1007/978-94-007-0753-5_2554
2014 Holliday EG, 'Statistical Inference', Encyclopedia of Quality of Life and Well-Being Research, Springer, Dordrecht, Netherlands 3258-3262 (2014) [D2]
2013 Holliday EG, Oldmeadow CJ, Maguire JM, Attia JR, 'Candidate gene association studies in stroke', Stroke Genetics, Springer Verlag, London 9-23 (2013) [B1]
Citations Scopus - 1
Co-authors Jane Maguire, John Attia, Christopher Oldmeadow
Show 2 more chapters

Journal article (78 outputs)

Year Citation Altmetrics Link
2015 Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, et al., 'Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease', Neurology, 84 918-926 (2015)

Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. Methods: We conducted met... [more]

Objectives: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. Methods: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that accounted for multiple testing and linkage disequilibrium between SNPs (p < 0.000084). Results: Three intronic SNPs in COL4A2 were significantly associated with deep intracerebral hemorrhage (lead SNP odds ratio [OR] 1.29, 95% confidence interval [CI] 1.14-1.46, p = 0.00003; r2 > 0.9 between SNPs). Although SNPs associated with deep intracerebral hemorrhage did not reach our significance threshold for association with lacunar ischemic stroke (lead SNP OR 1.10, 95% CI 1.03-1.18, p = 0.0073), and with white matter hyperintensity volume in symptomatic ischemic stroke patients (lead SNP OR 1.07, 95% CI 1.01-1.13, p = 0.016), the direction of association was the same. There was no convincing evidence of association with white matter hyperintensities in population-based studies or with non-small vessel disease cerebrovascular phenotypes. Conclusions: Our results indicate an association between common variation in the COL4A2 gene and symptomatic small vessel disease, particularly deep intracerebral hemorrhage. These findings merit replication studies, including in ethnic groups of non-European ancestry.

DOI 10.1212/WNL.0000000000001309
Citations Scopus - 1
Co-authors John Attia, Chris Levi
2015 Sapkota Y, Low S-K, Attia J, Gordon SD, Henders AK, Holliday EG, et al., 'Association between endometriosis and the interleukin 1A (ILIA) locus', HUMAN REPRODUCTION, 30 239-248 (2015)
DOI 10.1093/humrep/deu267
Citations Scopus - 2Web of Science - 2
Co-authors Rodney Scott, John Attia
2015 Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, et al., 'New genetic loci link adipose and insulin biology to body fat distribution', Nature, 518 187-197 (2015)

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the g... [more]

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10-8). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.

DOI 10.1038/nature14132
Citations Scopus - 11Web of Science - 9
2015 Battey TWK, Valant V, Kassis SB, Kourkoulis C, Lee C, Anderson CD, et al., 'Recommendations from the international stroke genetics consortium, part 2: Biological sample collection and storage', Stroke, 46 285-290 (2015)
DOI 10.1161/STROKEAHA.114.006851
Citations Scopus - 2Web of Science - 2
Co-authors Jane Maguire
2015 Chan JPL, Thalamuthu A, Oldmeadow C, Armstrong NJ, Holliday EG, McEvoy M, et al., 'Genetics of hand grip strength in mid to late life', Age, 37 1-10 (2015)

Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been consistently identified. We aimed to i... [more]

Hand grip strength (GS) is a predictor of mortality in older adults and is moderately to highly heritable, but no genetic variants have been consistently identified. We aimed to identify single nucleotide polymorphisms (SNPs) associated with GS in middle-aged to older adults using a genome-wide association study (GWAS). GS was measured using handheld dynamometry in community-dwelling men and women aged 55¿85 from the Hunter Community Study (HCS, N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.

DOI 10.1007/s11357-015-9745-5
Co-authors John Attia, Christopher Oldmeadow, Roseanne Peel, Rodney Scott
2015 Hancock DB, Levy JL, Gaddis NC, Glasheen C, Saccone NL, Page GP, et al., 'Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.', Biol Psychiatry, (2015)
DOI 10.1016/j.biopsych.2015.01.003
Co-authors Rodney Scott, John Attia
2015 Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, et al., 'Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk', HUMAN MOLECULAR GENETICS, 24 1478-1492 (2015) [C1]
DOI 10.1093/hmg/ddu552
Co-authors Katie Ashton, Rodney Scott, John Attia
2015 Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, et al., 'Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949).', Mol Psychiatry, 20 183-192 (2015)
DOI 10.1038/mp.2014.188
Citations Scopus - 4Web of Science - 4
Co-authors Christopher Oldmeadow, John Attia, Rodney Scott, Peter Schofield
2015 Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, et al., 'Genetic studies of body mass index yield new insights for obesity biology.', Nature, 518 197-206 (2015)
DOI 10.1038/nature14177
Citations Scopus - 31Web of Science - 19
2015 Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, et al., 'Genetic overlap between diagnostic subtypes of ischemic stroke.', Stroke, 46 615-619 (2015)
DOI 10.1161/STROKEAHA.114.007930
Co-authors Chris Levi, Lisa Lincz, Jane Maguire, Christopher Oldmeadow, Rodney Scott, John Attia
2015 Gorski M, Tin A, Garnaas M, McMahon GM, Chu AY, Tayo BO, et al., 'Genome-wide association study of kidney function decline in individuals of European descent', KIDNEY INTERNATIONAL, 87 1017-1029 (2015) [C1]
DOI 10.1038/ki.2014.361
Citations Scopus - 2
2015 Malik R, Freilinger T, Winsvold BS, Anttila V, Vander Heiden J, Traylor M, et al., 'Shared genetic basis for migraine and ischemic stroke', Neurology, 84 2132-2145 (2015)

Objective: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. Methods: We applied 4 different approaches to large-scal... [more]

Objective: To quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation. Methods: We applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,425 controls) and IS (12,389 cases and 62,004 controls). First, we queried known genome-wide significant loci for both disorders, looking for potential overlap of signals. We then analyzed the overall shared genetic load using polygenic scores and estimated the genetic correlation between disease subtypes using data derived from these models. We further interrogated genomic regions of shared risk using analysis of covariance patterns between the 2 phenotypes using cross-phenotype spatial mapping. Results: We found substantial genetic overlap between migraine and IS using all 4 approaches. Migraine without aura (MO) showed much stronger overlap with IS and its subtypes than migraine with aura (MA). The strongest overlap existed between MO and large artery stroke (LAS; p 6.4 × 10-28 for the LAS polygenic score in MO) and between MO and cardioembolic stroke (CE; p 2.7 × 10-20 for the CE score in MO). Conclusions: Our findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms. Our observations on MA are consistent with a limited role of common genetic variants in this subtype.

DOI 10.1212/WNL.0000000000001606
Citations Scopus - 1Web of Science - 1
Co-authors Jane Maguire
2015 Gorski M, Tin A, Garnaas M, McMahon GM, Chu AY, Tayo BO, et al., 'Genome-wide association study of kidney function decline in individuals of European descent.', Kidney international, 87 1017-1029 (2015) [C1]
DOI 10.1038/ki.2014.361
Citations Scopus - 2
2015 Achterberg S, Kappelle LJ, De Bakker PIW, Traylor M, Algra A, Van Der Graaf Y, et al., 'No additional prognostic value of genetic information in the prediction of vascular events after cerebral ischemia of arterial origin: The PROMISe study', PLoS ONE, 10 (2015)

Background: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limit... [more]

Background: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that cerebral ischemia has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. Methods and Results: We studied 1020 patients with cerebral ischemia and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new ischemic events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of ischemic stroke (using summary statistics from the METASTROKE study which included 12389 cases and 62004 controls), the AUC-ROC remained the same. Similar results were found for the secondary outcome ischemic stroke. Conclusions: We found no additional value of genetic information in a prognostic model for the risk of ischemic events in patients with cerebral ischemia of arterial origin. This is consistent with a complex, polygenic architecture, where many genes of weak effect likely act in concert to influence the heritable risk of an individual to develop (recurrent) vascular events. At present, genetic information cannot help clinicians to distinguish patients at high risk for recurrent vascular events.

DOI 10.1371/journal.pone.0119203
2015 Denham JW, Steigler A, Joseph D, Lamb DS, Spry NA, Duchesne G, et al., 'Radiation dose escalation or longer androgen suppression for locally advanced prostate cancer? Data from the TROG 03.04 RADAR trial.', Radiother Oncol, 115 301-307 (2015)
DOI 10.1016/j.radonc.2015.05.016
Co-authors Allison Steigler, John Attia, Christopher Oldmeadow
2015 Abdullah N, Abdul Murad NA, Attia J, Oldmeadow C, Mohd Haniff EA, Syafruddin SE, et al., 'Characterizing the genetic risk for Type 2 diabetes in a Malaysian multi-ethnic cohort.', Diabet Med, (2015)
DOI 10.1111/dme.12735
Co-authors John Attia, Christopher Oldmeadow
2015 Sapkota Y, Attia J, Gordon SD, Henders AK, Holliday EG, Rahmioglu N, et al., 'Genetic burden associated with varying degrees of disease severity in endometriosis.', Mol Hum Reprod, 21 594-602 (2015)
DOI 10.1093/molehr/gav021
Co-authors John Attia
2015 Ibrahim-Verbaas CA, Bressler J, Debette S, Schuur M, Smith AV, Bis JC, et al., 'GWAS for executive function and processing speed suggests involvement of the CADM2 gene.', Mol Psychiatry, (2015)
DOI 10.1038/mp.2015.37
Co-authors John Attia, Peter Schofield, Christopher Oldmeadow
2015 Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, et al., 'Genome-wide studies of verbal declarative memory in nondemented older people: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium', Biological Psychiatry, 77 749-763 (2015)

BACKGROUND: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal ... [more]

BACKGROUND: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting. METHODS: We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia- and stroke-free individuals of European descent, aged =45 years. Replication of suggestive associations (p < 5 × 10-6) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. RESULTS: rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 × 10-10) and replication cohorts (p = 5.65 × 10-8). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 × 10-8, and rs6813517 [SPOCK3], p = 2.58 × 10-8) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism. CONCLUSIONS: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.

DOI 10.1016/j.biopsych.2014.08.027
Citations Scopus - 1
Co-authors John Attia
2014 Oldmeadow C, Mossman D, Evans TJ, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1]
DOI 10.1016/j.jpsychires.2014.01.011
Citations Scopus - 1Web of Science - 1
Co-authors Rodney Scott, John Attia, Christopher Oldmeadow, Murray Cairns, Paul Tooney
2014 Springelkamp H, Höhn R, Mishra A, Hysi PG, Khor C-C, Loomis SJ, et al., 'Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process', Nature Communications, 5 (2014) [C1]

Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Co... [more]

Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition.

DOI 10.1038/ncomms5883
Citations Scopus - 10
Co-authors John Attia, Rodney Scott
2014 Traylor M, Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, et al., 'A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach.', PLoS Genet, 10 e1004469 (2014) [C1]
DOI 10.1371/journal.pgen.1004469
Citations Scopus - 6Web of Science - 6
Co-authors Jane Maguire, John Attia, Chris Levi
2014 Evans TJ, Milne E, Anderson D, de Klerk NH, Jamieson SE, Talseth-Palmer BA, et al., 'Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures.', PLoS One, 9 e110255 (2014) [C1]
DOI 10.1371/journal.pone.0110255
Citations Scopus - 1Web of Science - 1
Co-authors Bente Talseth-Palmer, Rodney Scott, Nikola Bowden, John Attia
2014 Holliday EG, Attia J, Hancock S, Koloski N, McEvoy M, Peel R, et al., 'Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome', American Journal of Gastroenterology, 109 770-772 (2014) [C1]
DOI 10.1038/ajg.2014.56
Citations Scopus - 2Web of Science - 2
Co-authors John Attia, Rodney Scott, Nicholas Talley, Roseanne Peel
2014 Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, et al., 'Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12', NEUROLOGY, 83 678-685 (2014) [C1]
Citations Scopus - 13Web of Science - 14
Co-authors Chris Levi
2014 Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, et al., 'Polygenic Overlap Between Kidney Function and Large Artery Atherosclerotic Stroke', STROKE, 45 3508-+ (2014) [C1]
DOI 10.1161/STROKEAHA.114.006609
Co-authors Chris Levi, John Attia, Rodney Scott, Jane Maguire, Christopher Oldmeadow
2014 Malik R, Bevan S, Nalls MA, Holliday EG, Devan WJ, Cheng Y-C, et al., 'Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies', Stroke, 45 394-402 (2014) [C1]

Background and Purpose - Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggrega... [more]

Background and Purpose - Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective population-based cohorts. Methods - Three thousand five hundred forty-eight clinic-based IS cases and 6399 controls from the Wellcome Trust Case Control Consortium 2 were used for derivation of the GRS. Subjects from the METASTROKE consortium served as a replication sample. The validation sample consisted of 22 751 participants from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium. We selected variants that had reached genome-wide significance in previous association studies on established risk factors for IS. Results - A combined GRS for atrial fibrillation, coronary artery disease, hypertension, and systolic blood pressure significantly associated with IS both in the case-control samples and in the prospective population-based studies. Subjects in the top quintile of the combined GRS had >2-fold increased risk of IS compared with subjects in the lowest quintile. Addition of the combined GRS to a simple model based on sex significantly improved the prediction of IS in the combined clinic-based samples but not in the population-based studies, and there was no significant improvement in net reclassification. Conclusions - A multilocus GRS based on common variants for established cardiovascular risk factors was significantly associated with IS both in clinic-based samples and in the general population. However, the improvement in clinical risk prediction was found to be small. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.113.002938
Citations Scopus - 11Web of Science - 8
Co-authors Chris Levi
2014 Cotlarciuc I, Malik R, Holliday EG, Ahmadi KR, Paré G, Psaty BM, et al., 'Effect of genetic variants associated with plasma homocysteine levels on stroke risk', Stroke, 45 1920-1924 (2014) [C1]

BACKGROUND AND PURPOSE - : Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are... [more]

BACKGROUND AND PURPOSE - : Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by assessing 18 polymorphisms previously associated with tHcy levels for their association with IS and its subtypes. METHODS - : Previous meta-analysis results from an international stroke collaborative network, METASTROKE, were used to assess association of the 18 tHcy-associated single-nucleotide polymorphisms (SNPs) in 12 389 IS cases and 62 004 controls. We also investigated the associations in regions located within 50 kb from the 18 tHcy-related SNPs and the association of a genetic risk score, including the 18 SNPs. RESULTS - : One SNP located in the RASIP1 gene and a cluster of 3 SNPs located at and near SLC17A3 were significantly associated with IS (P<0.0003) after correcting for multiple testing. For stroke subtypes, the sentinel SNP located upstream of MUT was significantly associated with small-vessel disease (P=0.0022), whereas 1 SNP located in MTHFR was significantly associated with large-vessel disease (P=0.00019). A genetic risk score, including the 18 SNPs, did not show significant association with IS or its subtypes. CONCLUSIONS - : This study found several potential associations with IS and its subtypes: An association of an MUT variant with small-vessel disease, an MTHFR variant with large-vessel disease, and associations of RASIP1 and SLC17A3 variants with overall IS. © 2014 American Heart Association, Inc.

DOI 10.1161/STROKEAHA.114.005208
Citations Scopus - 1Web of Science - 1
2014 Wang JJ, Buitendijk GHS, Rochtchina E, Lee KE, Klein BEK, Van Duijn CM, et al., 'Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations', Ophthalmology, 121 667-675 (2014)
DOI 10.1016/j.ophtha.2013.10.017
Citations Scopus - 2
Co-authors Wayne Smith, John Attia
2014 Wang JJ, Buitendijk GHS, Rochtchina E, Lee KE, Klein BEK, Van Duijn CM, et al., 'Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations', Ophthalmology, 121 667-675 (2014) [C1]

Objective To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk. Design P... [more]

Objective To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk. Design Pooled data analysis of population-based cohorts. Participants Participants from the Blue Mountains Eye Study (BMES) and Rotterdam Study (RS). Methods Dietary intakes of antioxidants (lutein/zeaxanthin [LZ], ß-carotene, and vitamin C), long-chain omega-3 polyunsaturated fatty acids, and zinc were estimated from food frequency questionnaires. The AMD genetic risk was classified according to the number of risk alleles of CFH (rs1061170) or ARMS2 (rs10490924) as low (no or 1 risk allele) or high (=2 risk alleles). Interactions between dietary intake and genetic risk levels were assessed. Associations between dietary intake and AMD risk were assessed comparing the highest with the 2 lower intake tertiles by genetic risk subgroups using discrete logistic regression, conducted in each study separately and then using pooled data. Participants without AMD lesions at any visit were controls. We adjusted for age and sex in analyses of each cohort sample and for smoking status and study site in pooled-data analyses. Main Outcome Measures All 15-year incident late AMD cases were confirmed by chief investigators of the Beaver Dam Eye Study, BMES, and RS. Intergrader reproducibility was assessed in an early AMD subsample, with 86.4% agreement between BMES and RS graders, allowing for a 1-step difference on a 5-step AMD severity scale. Results In pooled data analyses, we found significant interaction between AMD genetic risk status and LZ intake (P = 0.0009) but nonsignificant interactions between genetic risk status and weekly fish consumption (P = 0.05) for risk of any AMD. Among participants with high genetic risk, the highest intake tertile of LZ was associated with a >20% reduced risk of early AMD, and weekly consumption of fish was associated with a 40% reduced risk of late AMD. No similar association was evident among participants with low genetic risk. No interaction was detected between ß-carotene or vitamin C and genetic risk status. Conclusions Protection against AMD from greater LZ and fish consumption in persons with high genetic risk based on 2 major AMD genes raises the possibility of personalized preventive interventions. ©2014 by the American Academy of Ophthalmology.

DOI 10.1016/j.ophtha.2013.10.017
Citations Scopus - 3Web of Science - 6
Co-authors Wayne Smith, John Attia
2014 De Vivo I, Prescott J, Setiawan VW, Olson SH, Wentzensen N, Attia J, et al., 'Genome-wide association study of endometrial cancer in E2C2', HUMAN GENETICS, 133 211-224 (2014) [C1]
DOI 10.1007/s00439-013-1369-1
Citations Scopus - 4Web of Science - 6
Co-authors John Attia, Rodney Scott
2014 Moir-Meyer GL, Pearson JF, Lose F, The ANECSG, Scott RJ, McEvoy M, et al., 'Rare germline copy number deletions of likely functional importance are implicated in endometrial cancer predisposition', Human Genetics, (2014)

Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk factors for this disease. This is the first geno... [more]

Endometrial cancer is the most common invasive gynaecological cancer in women, and relatively little is known about inherited risk factors for this disease. This is the first genome-wide study to explore the role of common and rare germline copy number variants (CNVs) in predisposition to endometrial cancer. CNVs were called from germline DNA of 1,209 endometrioid endometrial cancer cases and 528 cancer-unaffected female controls. Overall CNV load of deletions or DNA gains did not differ significantly between cases and controls (P > 0.05), but cases presented with an excess of rare germline deletions overlapping likely functional genomic regions including genes (P = 8 × 10-10), CpG islands (P = 1 × 10-7) and sno/miRNAs regions (P = 3 × 10-9). On average, at least one additional gene and two additional CpG islands were disrupted by rare deletions in cases compared to controls. The most pronounced difference was that over 30 sno/miRNAs were disrupted by rare deletions in cases for every single disruption event in controls. A total of 13 DNA repair genes were disrupted by rare deletions in 19/1,209 cases (1.6 %) compared to one gene in 1/528 controls (0.2 %; P = 0.007), and this increased DNA repair gene loss in cases persisted after excluding five individuals carrying CNVs disrupting mismatch repair genes MLH1, MSH2 and MSH6 (P = 0.03). There were 34 miRNA regions deleted in at least one case but not in controls, the most frequent of which encompassed hsa-mir-661 and hsa-mir-203. Our study implicates rare germline deletions of functional and regulatory regions as possible mechanisms conferring endometrial cancer risk, and has identified specific regulatory elements as candidates for further investigation.

DOI 10.1007/s00439-014-1507-4
Co-authors Rodney Scott, John Attia
2014 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT study (vol 73, pg 16, 2013)', ANNALS OF NEUROLOGY, 75 166-167 (2014)
DOI 10.1002/ana.24105
Co-authors Rodney Scott, Chris Levi, John Attia
2014 Moayyeri A, Hsu Y-H, Karasik D, Estrada K, Xiao S-M, Nielson C, et al., 'Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium', HUMAN MOLECULAR GENETICS, 23 3054-3068 (2014) [C1]
DOI 10.1093/hmg/ddt675
Citations Scopus - 6Web of Science - 4
Co-authors Christopher Oldmeadow, John Attia, Roseanne Peel, Rodney Scott
2014 Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, et al., 'Genome-wide association analysis identifies six new loci associated with forced vital capacity', NATURE GENETICS, 46 669-677 (2014) [C1]
DOI 10.1038/ng.3011
Citations Scopus - 8Web of Science - 7
Co-authors John Attia, Rodney Scott, Christopher Oldmeadow
2014 Oldmeadow C, Holliday EG, McEvoy M, Scott R, Kwok JBJ, Mather K, et al., 'Concordance between direct and imputed APOE genotypes using 1000 genomes data', Journal of Alzheimer's Disease, 42 391-393 (2014) [C1]

There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not included in any of the common microarray platforms. We com... [more]

There are a growing number of large cohorts of older persons with genome-wide genotyping data available, but APOE is not included in any of the common microarray platforms. We compared directly measured APOE genotypes with those imputed using microarray data and the '1000 Genomes' dataset in a sample of 320 Caucasians. We find 90% agreement for e2/e3/e4 genotypes and 93% agreement for predicting e4 status, yielding kappa values of 0.81 and 0.84, respectively. More stringent thresholds around allele number estimates can increase this agreement to 90-97% and kappas of 0.90-0.93.

DOI 10.3233/JAD-140846
Co-authors Peter Schofield, John Attia, Rodney Scott, Christopher Oldmeadow
2014 Abdullah N, Attia J, Oldmeadow C, Scott RJ, Holliday EG, 'The Architecture of Risk for Type 2 Diabetes: Understanding Asia in the Context of Global Findings', INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, (2014) [C1]
DOI 10.1155/2014/593982
Citations Scopus - 3Web of Science - 1
Co-authors John Attia, Christopher Oldmeadow, Rodney Scott
2014 Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, 'Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12', Neurology, 83 678-685 (2014) [C1]

Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.... [more]

Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p 5 7.12 3 10-11) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p 5 0.695).

Citations Scopus - 11Web of Science - 12
Co-authors Chris Levi
2014 Ek WE, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera NV, et al., 'Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.', Gut, (2014)
DOI 10.1136/gutjnl-2014-307997
Co-authors Nicholas Talley
2013 Debette S, Ibrahim Verbaas CA, Bressler J, Schuur M, Smith A, Bis JC, et al., 'Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium', Biological Psychiatry, (2013)

Background: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal ... [more]

Background: Memory performance in older persons can reflect genetic influences on cognitive function and dementing processes. We aimed to identify genetic contributions to verbal declarative memory in a community setting. Methods: We conducted genome-wide association studies for paragraph or word list delayed recall in 19 cohorts from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, comprising 29,076 dementia- and stroke-free individuals of European descent, aged =45 years. Replication of suggestive associations (p < 5 × 10-6) was sought in 10,617 participants of European descent, 3811 African-Americans, and 1561 young adults. Results: rs4420638, near APOE, was associated with poorer delayed recall performance in discovery (p = 5.57 × 10-10) and replication cohorts (p = 5.65 × 10-8). This association was stronger for paragraph than word list delayed recall and in the oldest persons. Two associations with specific tests, in subsets of the total sample, reached genome-wide significance in combined analyses of discovery and replication (rs11074779 [HS3ST4], p = 3.11 × 10-8, and rs6813517 [SPOCK3], p = 2.58 × 10-8) near genes involved in immune response. A genetic score combining 58 independent suggestive memory risk variants was associated with increasing Alzheimer disease pathology in 725 autopsy samples. Association of memory risk loci with gene expression in 138 human hippocampus samples showed cis-associations with WDR48 and CLDN5, both related to ubiquitin metabolism. Conclusions: This largest study to date exploring the genetics of memory function in ~40,000 older individuals revealed genome-wide associations and suggested an involvement of immune and ubiquitin pathways.

DOI 10.1016/j.biopsych.2014.08.027
Citations Scopus - 1
Co-authors Christopher Oldmeadow, John Attia, Peter Schofield
2013 Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, et al., 'Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke', Stroke, 44 2703-2709 (2013) [C1]
DOI 10.1161/STROKEAHA.113.002186
Citations Scopus - 3Web of Science - 3
Co-authors Jane Maguire, John Attia, Rodney Scott
2013 Adib-Samii P, Rost N, Traylor M, Devan W, Biffi A, Lanfranconi S, et al., '17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status', Stroke, 44 1609-1615 (2013) [C1]
Citations Scopus - 12Web of Science - 13
Co-authors Chris Levi, Jane Maguire
2013 Buitendijk GHS, Rochtchina E, Myers C, Van Duijn CM, Lee KE, Klein BEK, et al., 'Prediction of age-related macular degeneration in the general population: The three continent AMD consortium', Ophthalmology, 120 2644-2655 (2013) [C1]
DOI 10.1016/j.ophtha.2013.07.053
Citations Scopus - 16Web of Science - 14
Co-authors John Attia
2013 Schache M, Richardson AJ, Mitchell P, Wang JJ, Rochtchina E, Viswanathan AC, et al., 'Genetic association of refractive error and axial length with 15q14 but not 15q25 in the Blue Mountains Eye Study Cohort', Ophthalmology, 120 292-297 (2013) [C1]
Citations Scopus - 7Web of Science - 5
Co-authors Rodney Scott, John Attia
2013 Williams FMK, Carter AM, Hysi PG, Surdulescu G, Hodgkiss D, Soranzo N, et al., 'Ischemic stroke is associated with the ABO locus: The EuroCLOT Study', Annals of Neurology, 73 16-31 (2013) [C1]
Citations Scopus - 20Web of Science - 20
Co-authors Chris Levi, John Attia, Rodney Scott
2013 Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, De Andrade M, et al., 'Common variants in mendelian kidney disease genes and their association with renal function', Journal of the American Society of Nephrology, 24 2105-2117 (2013) [C1]

Many common genetic variants identified by genome-wide association studies for complex traitsmap to genes previously linked to rare inherited Mendelian disorders. A systematic ana... [more]

Many common genetic variants identified by genome-wide association studies for complex traitsmap to genes previously linked to rare inherited Mendelian disorders. A systematic analysis of common single-nucleotide polymorphisms (SNPs) in genes responsible for Mendelian diseases with kidney phenotypes has not been performed. We thus developed a comprehensive database of genes for Mendelian kidney conditions and evaluated the association between common genetic variants within these genes and kidney function in the general population. Using the Online Mendelian Inheritance in Man database, we identified 731 unique disease entries related to specific renal search terms and confirmed a kidney phenotype in 218 of these entries, corresponding to mutations in 258 genes. We interrogated common SNPs (minor allele frequency >5%) within these genes for association with the estimated GFR in 74,354 European-ancestry participants from the CKDGen Consortium. However, the top four candidate SNPs (rs6433115 at LRP2, rs1050700 at TSC1, rs249942 at PALB2, and rs9827843 at ROBO2) did not achieve significance in a stage 2meta-analysis performed in 56,246 additional independent individuals, indicating that these common SNPs are not associated with estimated GFR. The effect of less common or rare variants in these genes on kidney function in the general population and disease-specific cohorts requires further research. Copyright © 2013 by the American Society of Nephrology.

DOI 10.1681/ASN.2012100983
Citations Scopus - 4Web of Science - 2
2013 Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al., 'Genome-wide association analyses identify 18 new loci associated with serum urate concentrations', Nature Genetics, 45 145-154 (2013) [C1]
Citations Scopus - 74Web of Science - 74
Co-authors Christopher Oldmeadow, Rodney Scott, John Attia
2013 Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, et al., 'GWAS of 126,559 individuals identifies genetic variants associated with educational attainment', Science, 340 1467-1471 (2013) [C1]
Citations Scopus - 80Web of Science - 75
Co-authors Christopher Oldmeadow, Rodney Scott, John Attia
2013 Magee CA, Holliday EG, Attia JR, Kritharides L, Banks E, 'Investigation of the relationship between sleep duration, all-cause mortality, and preexisting disease', Sleep Medicine, 14 591-596 (2013) [C1]
Citations Scopus - 8Web of Science - 6
Co-authors John Attia
2013 Stambolian D, Wojciechowski R, Oexle K, Pirastu M, Li X, Raffel LJ, et al., 'Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error', Human Molecular Genetics, 22 2754-2764 (2013) [C1]
Citations Scopus - 13Web of Science - 13
Co-authors Rodney Scott, John Attia
2013 Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Avery-Kiejda KA, Scott RJ, 'STaRRRT: a table of short tandem repeats in regulatory regions of the human genome', BMC GENOMICS, 14 (2013) [C1]
DOI 10.1186/1471-2164-14-795
Citations Scopus - 6Web of Science - 6
Co-authors Nikola Bowden, Rodney Scott, Kelly Kiejda
2013 Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'Continuing difficulties in interpreting CNV data: Lessons from a genome-wide CNV association study of Australian HNPCC/lynch syndrome patients', BMC Medical Genomics, 6 1-13 (2013) [C1]
Citations Scopus - 4Web of Science - 3
Co-authors Bente Talseth-Palmer, John Attia, Rodney Scott
2013 Holliday EG, Magee CA, Kritharides L, Banks E, Attia J, 'Short Sleep Duration Is Associated with Risk of Future Diabetes but Not Cardiovascular Disease: a Prospective Study and Meta-Analysis', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0082305
Citations Scopus - 13Web of Science - 11
Co-authors John Attia
2013 Sun C, Young TL, Mackey DA, Van Zuydam NR, Doney ASF, Palmer CNA, et al., 'Genetic loci for retinal arteriolar microcirculation', PLoS One, 8 e65804 (2013) [C1]
Citations Scopus - 2Web of Science - 2
Co-authors John Attia, Rodney Scott
2013 Jensen RA, Sim X, Li X, Cotch MF, Ikram MK, Holliday EG, et al., 'Genome-wide association study of retinopathy in individuals without diabetes', PLoS One, 8 e54232 (2013) [C1]
Citations Scopus - 4Web of Science - 5
Co-authors John Attia, Rodney Scott
2013 Holliday EG, Smith AV, Cornes BK, Buitendijk GHS, Jensen RA, Sim X, et al., 'Insights into the genetic architecture of early stage age-related macular degeneration: A genome-wide association study meta-analysis', PLoS One, 8 e53830 (2013) [C1]
Citations Scopus - 28Web of Science - 26
Co-authors Rodney Scott, John Attia, Patrick Mcelduff
2013 Holliday EG, 'Hints of unique genetic effects for type 2 diabetes in India', Diabetes, 62 1369-1370 (2013) [C1]
Citations Scopus - 3Web of Science - 4
2012 Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, et al., 'Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke?', Stroke, 43 980-U143 (2012) [C1]
Citations Scopus - 11Web of Science - 11
Co-authors Pablo Moscato, Lisa Lincz, Jane Maguire, Rodney Scott, John Attia, Chris Levi
2012 Bellenguez C, Bevan S, Gschwendtner A, Spencer CCA, Burgess AI, Pirinen M, et al., 'Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke', Nature Genetics, 44 328-333 (2012) [C1]
DOI 10.1038/ng.1081
Citations Scopus - 118Web of Science - 93
Co-authors John Attia, Chris Levi
2012 Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Genome-wide association meta-analysis identifies new endometriosis risk loci', Nature Genetics, 44 1355-1359 (2012) [C1]
Citations Scopus - 57Web of Science - 48
Co-authors John Attia, Rodney Scott
2012 Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm J, et al., 'Common variants at 6p21.1 are associated with large artery atherosclerotic stroke', Nature Genetics, 44 1147-1153 (2012) [C1]
Citations Scopus - 47Web of Science - 47
Co-authors Jane Maguire, Lisa Lincz, Pablo Moscato, John Attia, Mark Parsons, Roseanne Peel, Rodney Scott, Christopher Oldmeadow, Chris Levi, Wayne Smith
2012 Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, et al., 'Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations', Nature Genetics, 44 904-909 (2012) [C1]
Citations Scopus - 37Web of Science - 39
Co-authors Rodney Scott, Christopher Oldmeadow, John Attia
2012 Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Boger CA, Endlich K, et al., 'Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function', Human Molecular Genetics, 21 5329-5343 (2012) [C1]
Citations Scopus - 17Web of Science - 17
2012 Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng Y-C, et al., 'Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies', The Lancet Neurology, 11 951-962 (2012) [C1]
Citations Scopus - 94Web of Science - 94
Co-authors Chris Levi, Jane Maguire
2012 Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger CA, Fuchsberger C, et al., 'Genome-wide association and functional follow-up reveals new loci for kidney function', PLOS Genetics, 8 1-15 (2012) [C1]
Citations Scopus - 42Web of Science - 43
2012 McAuley E, Scimone A, Tiwari Y, Agahi G, Mowry B, Holliday EG, et al., 'Identification of Sialyltransferase 8B as a Generalized Susceptibility Gene for Psychotic and Mood Disorders on Chromosome 15q25-26', PLoS One, 7 3817-3818 (2012) [C1]
Citations Scopus - 15
2011 Oldmeadow CJ, Riveros RC, Holliday EG, Scott R, Moscato PA, Wang JJ, et al., 'Sifting the wheat from the chaff: Prioritizing GWAS results by identifying consistency across analytical methods', Genetic Epidemiology, 35 745-754 (2011) [C1]
DOI 10.1002/gepi.20622
Citations Scopus - 5Web of Science - 5
Co-authors John Attia, Rodney Scott, Christopher Oldmeadow, Pablo Moscato
2011 Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C, Wright VJ, et al., 'Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease', Nature Genetics, 43 1241-1248 (2011) [C1]
Citations Scopus - 83Web of Science - 79
Co-authors Rodney Scott, John Attia
2010 Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, et al., 'Four Novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation In Vivo', Plos Genetics, 6 1-12 (2010) [C1]
DOI 10.1371/journal.pgen.1001184
Citations Scopus - 55Web of Science - 52
Co-authors John Attia, Rodney Scott
2010 Holliday EG, Scott R, Attia JR, 'Evidence-based medicine in the era of biomarkers: Teaching a new dog old tricks?', Clinical Pharmacology and Therapeutics, 88 740-742 (2010) [C2]
DOI 10.1038/clpt.2010.214
Citations Scopus - 4Web of Science - 2
Co-authors John Attia, Rodney Scott
2009 Holliday EG, Nyholt DR, Tirupati S, John S, Ramachandran P, Ramamurti M, et al., 'Strong evidence for a novel schizophrenia risk locus on chromosome 1p31.1 in homogeneous pedigrees from Tamil Nadu, India', American Journal of Psychiatry, 166 206-215 (2009) [C1]
DOI 10.1176/appi.ajp.2008.08030442
Citations Scopus - 7Web of Science - 9
2009 Psychiatric Gwas Consortium CC, Holliday EG, Cichon S, Craddock N, Daly M, Faraone S, et al., 'Genomewide association studies: history, rationale, and prospects for psychiatric disorders', American Journal of Psychiatry, 166 540-546 (2009) [C1]
Citations Scopus - 246
2009 Holliday EG, McLean DE, Nyholt DR, Mowry BJ, 'Susceptibility locus on chromosome 1q23-25 for a schizophrenia subtype resembling deficit schizophrenia identified by latent class analysis', Archives of General Psychiatry, 66 1058-1067 (2009) [C1]
DOI 10.1001/archgenpsychiatry.2009.136
Citations Scopus - 16
2009 Thara R, Tirupati S, John S, Nancarrow D, Chant D, Holliday E, Mowry B, 'Design and clinical characteristics of a homogeneous schizophrenia pedigree sample from Tamil Nadu, India', Australian and New Zealand Journal of Psychiatry, 43 561-570 (2009) [C1]
DOI 10.1080/00048670902873631
Citations Scopus - 2Web of Science - 3
2009 Jones AL, Holliday EG, Mowry BJ, McLean DE, McGrath JJ, Pender MP, Greer JM, 'CTLA-4 single-nucleotide polymorphisms in a Caucasian population with schizophrenia', Brain Behavior and Immunity, 23 347-350 (2009) [C1]
DOI 10.1016/j.bbi.2008.09.008
Citations Scopus - 7Web of Science - 7
2008 Holliday EG, Mowry BJ, Nyholt DR, 'A reanalysis of 409 European-ancestry and African American schizophrenia pedigrees reveals significant linkage to 8p23.3 with evidence of locus heterogeneity', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147 1080-1088 (2008) [C1]
DOI 10.1002/ajmg.b.30722
Citations Scopus - 4
2006 Handoko HY, James MR, McGrath JJ, Nertney DA, Tirupati S, Thara R, et al., 'Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples', Twin Research and Human Genetics, 9 531-539 (2006) [C1]
DOI 10.1375/183242706778025035
Citations Scopus - 18Web of Science - 16
2005 Holliday EG, Mowry B, Chant D, Nyholt D, 'The importance of modelling heterogeneity in complex disease: Application to NIMH Schizophrenia Genetics Initiative data', Human Genetics, 117 160-167 (2005) [C1]
DOI 10.1007/s00439-005-1282-3
Show 75 more journal articles

Conference (16 outputs)

Year Citation Altmetrics Link
2014 Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Avery-Kiejda KA, Scott RJ, 'Short tandem repeats are variable genetic elements that may have major consequences for multiple diseases.', The Australian Society for Medical Research (ASMR) Satellite Scientific Meeting Programme, Newcastle, NSW, Australia (2014)
Co-authors Nikola Bowden, Kelly Kiejda, Rodney Scott
2014 Bolton KA, Ross JP, Grice DM, Bowden NA, Holliday EG, Kiejda KA, Scott RJ, 'Short tandem repeats are variable genetic elements that may have major consequences for multiple diseases.', The Australian Society for Medical Research (ASMR) Satellite Scientific Meeting Programme, Newcastle, NSW, Australia (2014) [E3]
Co-authors Kelly Kiejda, Rodney Scott, Nikola Bowden
2014 Mather KA, Thalamuthu A, Oldmeadow C, Song F, Armstrong NJ, Poljak A, et al., 'Genome-wide significant results identified for plasma apolipoprotein h levels', Alzheimer's & Dementia (2014) [E3]
DOI 10.1016/j.jalz.2014.05.1526
Co-authors Christopher Oldmeadow, John Attia, Rodney Scott, Peter Schofield
2014 Chouraki VA, Jakobsdottir J, Mather K, Adams H, Mollon J, Oldmeadow C, et al., 'A genome-wide meta-analysis of plasma clusterin levels in the charge consortium', Alzheimer's & Dementia, Washington, DC (2014) [E3]
DOI 10.1016/j.jalz.2014.05.1159
Co-authors John Attia, Rodney Scott, Christopher Oldmeadow
2014 Bolton KA, Holliday EG, McEvoy M, Attia J, Proietto A, Otton G, et al., 'A HIGHLY POLYMORPHIC AG REPEAT IN THE UPSTREAM REGULATORY REGION OF THE ESTROGEN-INDUCED GENE EIG121 IS A POTENTIAL MODIFIER OF ENDOMETRIAL CANCER RISK', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Kelly Kiejda, Nikola Bowden, John Attia, Rodney Scott
2014 Bolton KA, Holliday EG, Bowden NA, Avery-Kiejda KA, Scott RJ, 'A highly polymorphic AG repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is a modifier of disease risk in endometrial cancer', EUROPEAN JOURNAL OF CANCER (2014) [E3]
Co-authors Nikola Bowden, Kelly Kiejda, Rodney Scott
2014 Bolton KA, Holliday EG, McEvoy M, Attia J, Proietto A, Otton G, et al., 'A highly polymorphic AG repeat in the upstream regulatory region of the estrogen gene EIG121 is a potential modifier of endometrial cancer risk.', Asia-Pacific Journal of Clinical Oncology, Newcastle, NSW, Australia (2014) [E3]
DOI 10.1111/ajco.12335
Co-authors Kelly Kiejda, John Attia, Nikola Bowden, Rodney Scott
2013 Bolton KA, Ross J, Grice DM, Avery-Kiejda KA, Bowden NA, Holliday EG, Scott RJ, 'Role of Short Tandem Repeats in Disease and Evolutionary Mechanisms.', 34th Lorne Genome Conference Proceedings, Lorne, VIC, Australia (2013) [E3]
Co-authors Rodney Scott, Kelly Kiejda, Nikola Bowden
2013 Bolton KA, Avery-Kiejda KA, Grice DM, Holliday EG, Bowden NA, Ross J, Scott RJ, 'STaRRRT: Our new resource for identifying candidates of genetic risk in breast and endometrial cancer.', Translational Cancer Research Conference Abstract booklet, Newcastle, Australia (2013) [E3]
Co-authors Nikola Bowden, Rodney Scott, Kelly Kiejda
2013 Thomas J, Parsons O, Traylor M, Li L, Bevan S, Sudlow C, et al., 'The impact of CCS and TOAST classification systems on genetic associations with ischaemic stroke', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
Co-authors John Attia, Chris Levi
2013 Nyholt DR, Low S-K, Anderson CA, Painter JN, Uno S, Morris AP, et al., 'Meta-Analysis of GWA Studies Identifies New Endometriosis Risk Loci', REPRODUCTIVE SCIENCES, Orlando, FL (2013) [E3]
Co-authors John Attia, Rodney Scott
2012 Bolton KA, Ross J, Grice DM, Kiejda KA, Bowden NA, Holliday EG, Scott R, 'Potential role of short tandem repeats in disease processes', Abstracts. 6th Australian Health & Medical Research Congress, Adelaide, SA (2012) [E3]
Co-authors Kelly Kiejda, Rodney Scott, Nikola Bowden
2012 Talseth-Palmer B, Holliday EG, Evans T-J, McEvoy MA, Attia JR, Grice DM, et al., 'A genome-wide CNV association study of Australian HNPCC/Lynch syndrome patients', Proceedings of the Australian Health & Medical Research Congress 2012, Adelaide, SA (2012) [E3]
Co-authors John Attia, Rodney Scott, Bente Talseth-Palmer
2011 Maguire JM, Holliday EG, Sturm J, Golledge J, Lewis M, Koblar S, et al., 'Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authors John Attia, Rodney Scott, Chris Levi, Pablo Moscato, Mark Parsons, Lisa Lincz, Jane Maguire
2010 Talseth-Palmer B, Holliday EG, Evans T-J, McPhillips M, Groombridge C, Spigelman AD, Scott R, 'Modifier genes influencing breast cancer incidence in HNPCC/Lynch syndrome', AMATA 2010 Conference: Conference Handbook, Hobart, Tasmania (2010) [E3]
Co-authors Rodney Scott, Bente Talseth-Palmer
2010 Talseth-Palmer B, Holliday EG, Evans T-J, McPhillips M, McEvoy MA, Attia JR, Scott R, 'A modern approach to the search for modifying genetic loci infleuncing the high breast cancer incidence seen in an Australian HNPCC/Lynch Syndrome cohort', Proceedings of the Australian Health and Medical Research Congress 2010, Melbourne, Vic (2010) [E3]
Co-authors John Attia, Bente Talseth-Palmer, Rodney Scott
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Grants and Funding

Summary

Number of grants 18
Total funding $2,558,580

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,031,671

Helping stroke physicians choose who to thrombolyse - the "Targeting Optimal Thrombolysis Outcomes" (TOTO) study$1,031,671

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Liz Holliday, Associate Professor Jane Maguire, Associate Professor Vincent Thijs, Dr Simon Koblar, Conjoint Associate Professor Jonathan Sturm, Professor John Attia, Doctor Lisa Lincz, Doctor Andrew Bivard
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1400237
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20143 grants / $565,000

A comprehensive research program designed to identify genetic causes and associated biological processes underlying ischaemic stroke$520,000

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Doctor Liz Holliday
Scheme Future Leader Fellowship
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1300632
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Biological characterisation of genetic associations for large artery atherosclerotic stroke$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Liz Holliday, Professor Rodney Scott, Conjoint Professor Chris Levi, Professor John Attia, Associate Professor Jane Maguire
Scheme Stroke Research Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301340
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Dietary iron during pregnancy: finding the right balance$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Alexis Hure, Doctor Amanda Patterson, Doctor Liz Holliday, Associate Professor Deb Loxton, Dr Amina Khambalia
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401399
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20135 grants / $157,700

A genome wide association study on childhood brain tumours$115,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Rodney Scott, Doctor Frank Alvaro, Miss Tiffany Evans, Professor John Attia, Doctor Liz Holliday, Dr Elizabeth Milne, Professor Bruce Armstrong
Scheme Research Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1301149
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

A pharmacogenomic study of intracerebral bleeding complicating the use of tissue plasminogen activator for acute ischaemic stroke$12,700

Funding Body: John Hunter Hospital Charitable Trust Fund Funding Scheme: Research Grant Description: Pharmacogenomics of thrombolysis in acute ischaemic stroke
Funding body Unknown
Project Team
Scheme Unknown
Role Lead
Funding Start 2013
Funding Finish 2014
GNo
Type Of Funding Internal
Category INTE
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300475
Type Of Funding Internal
Category INTE
UON Y

Discovery and validation of genetic associations with ischaemic stroke$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Liz Holliday
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300602
Type Of Funding Internal
Category INTE
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300704
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20123 grants / $240,209

Interplay of genetic and environmental factors on age-related cataract development$210,209

Funding Body: NHMRC (National Health & Medical Research Council) Funding Scheme: Project Grant Description: Epidemiology of age-related cataract
Funding body Unknown
Project Team
Scheme Unknown
Role Investigator
Funding Start 2012
Funding Finish 2014
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Doctor Lisa Lincz
Scheme Near Miss Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200675
Type Of Funding Internal
Category INTE
UON Y

Revealing cancer complexity - identification of Lynch syndrome cases$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Bente Talseth-Palmer, Professor Rodney Scott, Doctor Liz Holliday
Scheme Early Career Researcher Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200519
Type Of Funding Internal
Category INTE
UON Y

20111 grants / $4,000

HMRI Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Liz Holliday
Scheme PULSE Education Prize
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1101187
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

20102 grants / $325,000

Integrating genome-wide association, gene expression and DNA sequence data to identify risk variants for complex disease$285,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Liz Holliday
Scheme Early Career Fellowships
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0190305
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Equipment Grant$40,000

Funding Body: NHMRC (National Health & Medical Research Council) Funding Scheme: Equipment Grant Description: Equipment grant to establish high performance computing for genetic research
Funding body Unknown
Project Team
Scheme Unknown
Role Lead
Funding Start 2010
Funding Finish 2010
GNo
Type Of Funding Internal
Category INTE
UON Y

20091 grants / $160,000

Gladys M. Brawn Memorial Postdoctoral Fellowship$160,000

Funding Body: University of Newcastle Funding Scheme: Research Fellowship Description: Postdoctoral fellowship
Funding body Unknown
Project Team
Scheme Unknown
Role Lead
Funding Start 2009
Funding Finish 2010
GNo
Type Of Funding Internal
Category INTE
UON Y

20051 grants / $45,000

NHMRC Public Health Postgraduate Scholarship$45,000

Funding Body: NHMRC (National Health & Medical Research Council) Funding Scheme: Scholarships - Public Health Postgraduate Research Description: PhD scholarship
Funding body Unknown
Project Team
Scheme Unknown
Role Lead
Funding Start 2005
Funding Finish 2007
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20041 grants / $30,000

University of Queensland Postgraduate Scholarship$30,000

Funding Body: University of Queensland Funding Scheme: Research Scholarship Description: PhD scholarship

Funding body: University of Queensland

Funding body University of Queensland
Project Team
Scheme Research Scholarship
Role Lead
Funding Start 2004
Funding Finish 2005
GNo
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed0
Current2

Total current UON EFTSL

PhD0.35

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2012 PhD Genetic and Non-Genetic Studies of Type 2 Diabetes in Three Susceptible Asian Populations: Malay, Chinese and Indian
Health, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2010 PhD Role of Tandem Repeats in Genetic Susceptibility to Breast Cancer
Health, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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News

sleep

sleep linked to diabetes

December 12, 2013

Getting less than six hours sleep each night (compared to seven hours) may increase type 2 diabetes risk by 30 per cent but has less impact on heart disease than previously thought, researchers from the University of Newcastle have found.

Liz Holliday

Heart Foundation Fellowship

November 21, 2013

HMRI genetic statistician Dr Elizabeth Holliday has received a prestigious leadership fellowship from the Australian Heart Foundation to expand her international research work in determining the genetic causes of ischaemic stroke.

HMRI

New study shows genetic role in education

May 31, 2013

A multinational consortium of medical researchers and social scientists has found a link between educational attainment and tiny variations in a person's genetic sequence.

Dr Liz Holliday

Position

Conjoint Associate Professor
Clinical Research Design, IT and Statistical Support Unit
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email liz.holliday@newcastle.edu.au
Phone (02) 4042 0508
Fax (02) 4042 0039

Office

Room CReDITSS - HMRI
Building Hunter Medical Research Institute
Location John Hunter Hospital

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