Staff Profile
Career Summary
Biography
Dr Elizabeth Holliday is a genetic statistician with training in molecular bioscience (BSc Hons I - 2003), genetic epidemiology (PhD - 2008) and statistics (MSc - 2012). She is currently an NHMRC Postdoctoral Fellow (2010-2014). She joined the University of Newcastle in 2009 after completing doctoral studies at the University of Queensland (UQ).
Her primary research interest is large-scale genetic analyses of human traits, with a focus on ischaemic stroke and other vascular disorders. Her broad goal is to contribute to an improved understanding of the genetic architecture of vascular disease, and the genetic factors that might increase or decrease an individual's risk. Much of her postdoctoral research has utilised genome-wide association (GWAS) data to characterise the role of genetic variants that are common in the population.
She currently Chairs the Genetic Analysis Group for the International Stroke Genetics Consortium (ISGC), a collaborative of dedicated stroke researchers and clinicians with about 100 members from the USA, Europe, Australia, Asia and South America. The centralised Analysis Group applies novel analytic methods to Consortium datasets to provide new insights into stroke genetics and biology. As Chair of the group, she both scientifically and administratively leads projects within the ISGC. She also participates in the USA-based Chronic Kidney Disease (CKDGen) and CHARGE consortia (EYE working group, plus others). In collaboration with these groups, she is undertaking research investigating potential genetic parallels between stroke, kidney disease and ophthalmologic (eye) traits.
Dr Holliday has published nearly 40 journal papers, including a number in leading journals (e.g. Nature Genetics, Science, Lancet Neurology). She has also published several book chapters, received a range of competive grants, and a number of awards for her research.
Qualifications
- PhD, University of Queensland, 18/03/2008
- Bachelor of Science (Honours), University of Queensland, 10/12/2003
- Master of Science (Statistics), University of Queensland, 07/12/2012
Research
Research keywords
- Biostatistics
- Genetic association
- Genetic epidemiology
- Statistical genetics
Research expertise
Liz has research expertise in biostatistics, genetic epidemiology, human disease mapping, and traditional epidemiology. She has substantial experience in the design and conduct of genome-wide association studies of various complex diseases, particularly stroke, kidney disease, and eye disorders such as macular degeneration. She also has experience with more classical epidemiological research, including case-control and prospective cohort observational studies.
Languages
- English
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 010402 | Biostatistics | 35 |
| 060412 | Quantitative Genetics (Incl. Disease And Trait Mapping Genetics | 35 |
| 060408 | Genomics | 30 |
Memberships
Committee/Associations (relevant to research).
- Member - International Stroke Genetics Consortium
Appointments
| Fellowship National Health & Medical Research Council (Australia) | 01/01/2010 |
Awards
Honours.
| 2013 | High Flyers Think Tank Australian Academy of Science (Australia) Selected by the Australian Academy of Science (AAS) as participant and "Group Rapporteur”, to report recommendations from Group C: Artificial Intelligence, Maths and Modelling - 2013 AAS “High Flyers Think Tank”: Inspiring smarter brain research in Australia |
|---|---|
| 2012 | Star Graduate Biostatistics Collaboration of Australia (Australia) For academic performance in the Master of Statistics |
| 2002 | Dean's Commendation for High Achievement in Bachelor of Science University of Queensland (Australia) Study award |
Research Award.
| 2013 | Career Development Award International Stroke Genetics Consortium (United States) Travel Award |
|---|---|
| 2011 | Best Platform (Oral) Presentation Asia Pacific Stroke Conference (Sri Lanka) Conference Award |
| 2011 | Peter Bladin New Investigator Award Stroke Society of Australasia (Australia) Conference Award |
| 2011 | Young Investigator Travel Award Stroke Society of Australasia (Australia) Travel Award |
| 2011 | Education Prize Hunter Medical Research Institute (Australia) Conference Travel Award |
| 2007 | Best Student Poster Presentation Australasian GeneMappers Conference (Australia) Conference Award |
Teaching
Teaching keywords
- Biostatistics
Teaching expertise
2011-2012: Course Coordinator for BIOS6910 (Biostatistics A); annual enrollment of about 150 postgraduate students.
Grants and Funding
Summary
| Number of grants | 14 |
|---|---|
| Total funding | $946,909 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2013 (5 grants)
A genome wide association study on childhood brain tumours$100,000
Funding Body: Hunter Medical Research Institute
| Scheme | Role | |
|---|---|---|
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $100,000 | 2013 | 2014 |
| GNo:183961203 | ||
A pharmacogenomic study of intracerebral bleeding complicating the use of tissue plasminogen activator for acute ischaemic stroke$12,700
Funding Body: John Hunter Hospital Charitable Trust Fund
| Scheme | Role | |
|---|---|---|
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $12,700 | 2013 | 2014 |
| GNo:183961211 | ||
Discovery and validation of genetic associations with ischaemic stroke$10,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Doctor Liz Holliday | ||
| Scheme | Role | |
| Early Career Researcher Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2013 | 2013 |
| GNo:G1300602 | ||
The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire | ||
| Scheme | Role | |
| Near Miss | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2013 | 2013 |
| GNo:G1300704 | ||
The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire | ||
| Scheme | Role | |
| Near Miss Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2013 | 2013 |
| GNo:G1300475 | ||
2012 (3 grants)
Interplay of genetic and environmental factors on age-related cataract development$210,209
Funding Body: NHMRC (National Health & Medical Research Council)
| Scheme | Role | |
|---|---|---|
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $210,209 | 2012 | 2014 |
| GNo:183961223 | ||
The genetic determinants of brain haemorrhage associated with stroke thrombolysis$20,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Conjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Doctor Lisa Lincz | ||
| Scheme | Role | |
| Near Miss Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2012 | 2012 |
| GNo:G1200675 | ||
Revealing cancer complexity - identification of Lynch syndrome cases$10,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Doctor Bente Talseth-Palmer, Professor Rodney Scott, Doctor Liz Holliday | ||
| Scheme | Role | |
| Early Career Researcher Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2012 | 2012 |
| GNo:G1200519 | ||
2011 (1 grants)
HMRI Education Prize$4,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Liz Holliday | ||
| Scheme | Role | |
| PULSE Education Prize | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $4,000 | 2011 | 2012 |
| GNo:G1101187 | ||
2010 (2 grants)
Integrating genome-wide association, gene expression and DNA sequence data to identify risk variants for complex disease$285,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Liz Holliday | ||
| Scheme | Role | |
| Early Career Fellowships | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $285,000 | 2010 | 2013 |
| GNo:G0190305 | ||
Equipment Grant$40,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Scheme | Role | |
|---|---|---|
| Equipment Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $40,000 | 2010 | 2010 |
| GNo:183961231 | ||
2009 (1 grants)
Gladys M. Brawn Memorial Postdoctoral Fellowship$160,000
Funding Body: University of Newcastle
| Scheme | Role | |
|---|---|---|
| Research Fellowship | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $160,000 | 2009 | 2010 |
| GNo:183961239 | ||
2005 (1 grants)
NHMRC Public Health Postgraduate Scholarship$45,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Scheme | Role | |
|---|---|---|
| Scholarships - Public Health Postgraduate Research | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $45,000 | 2005 | 2007 |
| GNo:183961259 | ||
2004 (1 grants)
University of Queensland Postgraduate Scholarship$30,000
Funding Body: University of Queensland
| Scheme | Role | |
|---|---|---|
| Research Scholarship | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $30,000 | 2004 | 2005 |
| GNo:183961247 | ||
Research Supervision
| Number of current supervisions | 2 |
|---|---|
| Total current UoN PhD EFTSL | 0.35 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2012 | 2016 | PhD (Medical Genetics) | Principal Supervisor | Genetic and Non-Genetic Studies of Type 2 Diabetes in Three Susceptible Asian Populations: Malay, Chinese and Indian |
| 2010 | 2016 | PhD (Medical Genetics) | Co-Supervisor | Role of Tandem Repeats in Genetic Susceptibility to Breast Cancer |
Dr (Liz) Holliday
| Work Phone | (02) 4042 0508 |
|---|---|
| Fax | (02) 4042 0039 |
| Liz.Holliday@newcastle.edu.au | |
| Position | Research Fellow Clinical Research Design, IT and Statistical Support Unit School of Medicine and Public Health Faculty of Health and Medicine |
| Office | CReDITSS - HMRI, Hunter Medical Research Institute, John Hunter Hospital |
| URL: | www.newcastle.edu.au/profile/liz-holliday |
| Link | http://www.newcastle.edu.au/profile/liz-holliday |
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