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Dr Lisa Lincz

Conjoint Senior Lecturer

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Research Expertise

Genetic susceptibility to disease and treatment toxicity, Mechanisms of snakebite coagulopathy, Investigating the function of circulating microparticles, Investigating a novel target on the surface of leukaemia cells, Epigenetics of atherothrombotic disease.


Qualifications

  • PhD (Medicine), University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle
  • Graduate Diploma in Clinical Epidemiology, University of Newcastle

Keywords

  • Cardiovascular Medicine
  • Haematology

Fields of Research

CodeDescriptionPercentage
060499Genetics not elsewhere classified30
110399Clinical Sciences not elsewhere classified40
110299Cardiorespiratory Medicine and Haematology not elsewhere classified30
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (56 outputs)

YearCitationAltmetricsLink
2015Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, et al., 'Genetic overlap between diagnostic subtypes of ischemic stroke.', Stroke, 46 615-619 (2015)
DOI10.1161/STROKEAHA.114.007930Author URL
Co-authorsChris Levi, Liz Holliday, Christopher Oldmeadow, Rodney Scott, John Attia, Jane Maguire
2014Clancy P, Lincz LF, Maguire J, McEvoy M, Koblar SA, Golledge J, 'Tenascin-C is increased in atherothrombotic stroke patients and has an anti-inflammatory effect in the human carotid artery.', Biofactors, 40 448-457 (2014) [C1]
DOI10.1002/biof.1170Author URL
Co-authorsJane Maguire
2014Maduwage K, O'Leary MA, Scorgie FE, Shahmy S, Mohamed F, Abeysinghe C, et al., 'Detection of venom after antivenom is not associated with persistent coagulopathy in a prospective cohort of Russell's viper (Daboia russelii) envenomings.', PLoS Negl Trop Dis, 8 e3304 (2014) [C1]
DOI10.1371/journal.pntd.0003304Author URL
Co-authorsGeoff Isbister
2014Lincz LF, Scorgie FE, Johnston CI, O'Leary M, Prasad R, Seldon M, et al., 'Comparative sensitivity of commercially available aPTT reagents to mulga snake (Pseudechis australis) venom.', Pathology, 46 444-449 (2014) [C1]
DOI10.1097/PAT.0000000000000120Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsGeoff Isbister
2014Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, et al., 'ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer', American Journal of Pathology, 184 3156-3162 (2014) [C1]

Nerve infiltration is essential to prostate cancer progression, but the mechanism by which nerves are attracted to prostate tumors remains unknown. We report that the precursor of nerve growth factor (proNGF) is overexpressed in prostate cancer and involved in the ability of prostate cancer cells to induce axonogenesis. A series of 120 prostate cancer and benign prostate hyperplasia (BPH) samples were analyzed by IHC for proNGF. ProNGF was mainly localized in the cytoplasm of epithelial cells, with marked expression in cancer compared with BPH. Importantly, the proNGF level positively correlated with the Gleason score (n = 104, tB = 0.51). A higher level of proNGF was observed in tumors with a Gleason score of =8 compared with a Gleason score of 7 and 6 (P < 0.001). In vitro, proNGF was detected in LNCaP, DU145, and PC-3 prostate cancer cells and BPH-1 cells but not in RWPE-1 immortalized nontumorigenic prostate epithelial cells or primary normal prostate epithelial cells. Co-culture of PC12 neuronal-like cells or 50B11 neurons with PC-3 cells resulted in neurite outgrowth in neuronal cells that was inhibited by blocking antibodies against proNGF, indicating that prostate cancer cells can induce axonogenesis via secretion of proNGF. These data reveal that ProNGF is a biomarker associated with high-risk prostate cancers and a potential driver of infiltration by nerves.

DOI10.1016/j.ajpath.2014.08.009
CitationsScopus - 2Web of Science - 1
Co-authorsMarjorie Walker, Phillip Jobling, Rick Thorne, Hubert Hondermarck
2014Golledge J, Clancy P, Maguire J, Lincz L, Koblar S, Mcevoy M, et al., 'Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence', Stroke, 45 1064-1068 (2014) [C1]
DOI10.1161/STROKEAHA.113.004339
CitationsScopus - 1
Co-authorsChris Levi, John Attia, Jane Maguire
2014Golledge J, Clancy P, Maguire J, Lincz L, Koblar S, Mcevoy M, et al., 'Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence', Stroke, 45 1064-1068 (2014) [C1]

BACKGROUND AND PURPOSE - : Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS - : Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS - : Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS - : Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes. © 2014 American Heart Association, Inc.

DOI10.1161/STROKEAHA.113.004339
CitationsScopus - 1Web of Science - 1
Co-authorsJane Maguire, John Attia, Chris Levi
2014Phang M, Scorgie FE, Seldon M, Garg ML, Lincz LF, 'Reduction of prothrombin and Factor V levels following supplementation with omega-3 fatty acids is sex dependent: A randomised controlled study', Journal of Nutritional Biochemistry, 25 997-1002 (2014) [C1]

Background: LCn-3PUFA comprised of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) offer cardioprotection involving a decrease in coagulant activity; however, the evidence is equivocal. We have previously demonstrated that the acute (24. h) effects and chronic (4. weeks) effects of LCn-3PUFA supplementation on platelet aggregation in human subjects are sex specific. This study investigated the mechanisms of the sex-dependent effects of LCn-3PUFA with 4. weeks supplementation of EPA-rich vs. DHA-rich oils on procoagulant and platelet activity in healthy subjects. Design: A double-blinded, placebo-controlled randomised trial was conducted in 94 healthy adults: male (. n=41) and female (. n=53). Platelet coagulation parameters including factors I, II, V, VII, VIII, IX, X, vWF:Ag and endogenous thrombin potential were measured at baseline and 4. weeks postsupplementation with EPA-rich or DHA-rich oil capsules. Results: We have previously reported that platelet aggregation is specifically reduced by supplementation with EPA in males and DHA in females. This sex-specific effect was also observed for decreases in plasma levels of Factor II (-7.9±3.8%, P=.026), Factor V (-6.5±4.5%, P=.022) and vWF:Ag (-7.3±2.1%, P=.034) and was most pronounced in males supplemented with EPA. In contrast, DHA-mediated reduction in platelet aggregation in females was not accompanied by any significant changes in the coagulation parameters tested. Conclusion: Significant interactions between sex and specific LCn-3PUFA exist to reduce procoagulant activity differentially in males vs. females and could have profound effects on managing risk of thrombotic disease.

DOI10.1016/j.jnutbio.2014.05.001
Co-authorsManohar Garg
2014Clancy P, Lincz LF, Maguire J, McEvoy M, Koblar SA, Golledge J, 'Tenascin-C is increased in atherothrombotic stroke patients and has an anti-inflammatory effect in the human carotid artery.', BioFactors (Oxford, England), 40 448-457 (2014) [C1]
DOI10.1002/biof.1170
CitationsScopus - 1
Co-authorsJane Maguire
2013Phang M, Lincz LF, Garg ML, 'Eicosapentaenoic and Docosahexaenoic Acid Supplementations Reduce Platelet Aggregation and Hemostatic Markers Differentially in Men and Women', JOURNAL OF NUTRITION, 143 457-463 (2013) [C1]
DOI10.3945/jn.112.171249Author URL
CitationsScopus - 10Web of Science - 12
Co-authorsManohar Garg
2013Ardjmand A, de Bock CE, Shahrokhi S, Lincz LF, Boyd AW, Burns GF, Thorne RF, 'Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia', HEMATOLOGY, 18 315-321 (2013) [C1]
DOI10.1179/1607845413Y.0000000080Author URL
Co-authorsRick Thorne
2013Isbister GK, Buckley NA, Page CB, Scorgie FE, Lincz LF, Seldon M, Brown SGA, 'A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18)', Journal of Thrombosis and Haemostasis, 11 1310-1318 (2013) [C1]
DOI10.1111/jth.12218Author URL
CitationsScopus - 9Web of Science - 7
Co-authorsGeoff Isbister
2013Maduwage K, Scorgie FE, Silva A, Shahmy S, Mohamed F, Abeysinghe C, et al., 'Hump-nosed pit viper (Hypnale hypnale) envenoming causes mild coagulopathy with incomplete clotting factor consumption', CLINICAL TOXICOLOGY, 51 527-531 (2013) [C1]
DOI10.3109/15563650.2013.811589Author URL
CitationsScopus - 5Web of Science - 5
Co-authorsGeoff Isbister
2013Alkhatatbeh MJ, Enjeti AK, Acharya S, Thorne RF, Lincz LF, 'The origin of circulating CD36 in type 2 diabetes', NUTRITION & DIABETES, 3 (2013) [C1]
DOI10.1038/nutd.2013.1Author URL
CitationsScopus - 8Web of Science - 6
Co-authorsRick Thorne
2012Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, et al., 'Are myocardial infarction-associated single-nucleotide polymorphisms associated with ischemic stroke?', Stroke, 43 980-U143 (2012) [C1]
CitationsScopus - 11Web of Science - 11
Co-authorsPablo Moscato, John Attia, Rodney Scott, Liz Holliday, Chris Levi, Jane Maguire
2012Lincz L, Scorgie FE, Enjeti A, Seldon M, 'Variable plasma levels of Factor V Leiden correlate with circulating platelet microparticles in carriers of Factor V Leiden', Thrombosis Research, 129 192-196 (2012) [C1]
CitationsScopus - 2Web of Science - 2
2012De Bock CE, Ardjmand Ghahestani A, Molloy TJ, Bone SM, Johnstone DM, Campbell DM, et al., 'The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia', Leukemia, 26 918-926 (2012) [C1]
CitationsScopus - 11Web of Science - 12
Co-authorsRick Thorne
2012Phang M, Sinclair AJ, Lincz L, Garg ML, 'Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation', Nutrition Metabolism and Cardiovascular Diseases, 22 109-114 (2012) [C1]
CitationsScopus - 17Web of Science - 12
Co-authorsManohar Garg
2012Phang M, Lincz L, Seldon M, Garg ML, 'Acute supplementation with eicosapentaenoic acid reduces platelet microparticle activity in healthy subjects', Journal of Nutritional Biochemistry, 23 1128-1133 (2012) [C1]
CitationsScopus - 6Web of Science - 6
Co-authorsManohar Garg
2012Holliday EG, Maguire JM, Evans T-J, Koblar SA, Jannes J, Sturm J, et al., 'Common variants at 6p21.1 are associated with large artery atherosclerotic stroke', Nature Genetics, 44 1147-1153 (2012) [C1]
CitationsScopus - 44Web of Science - 44
Co-authorsChris Levi, Liz Holliday, Christopher Oldmeadow, Rodney Scott, Wayne Smith, Roseanne Peel, Pablo Moscato, John Attia, Mark Parsons, Jane Maguire
2012Garg MB, Lincz L, Adler K, Scorgie FE, Ackland S, Sakoff JA, 'Predicting 5-Fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length - A multivariate analysis', British Journal of Cancer, 107 1525-1533 (2012) [C1]
CitationsScopus - 4Web of Science - 5
Co-authorsJennette Sakoff, Stephen Ackland
2011Alkhatatbeh MJ, Mhaidat NM, Enjeti AK, Lincz L, Thorne RF, 'The putative diabetic plasma marker, soluble CD36, is non-cleaved, non-soluble and entirely associated with microparticles', Journal of Thrombosis and Haemostasis, 9 844-851 (2011) [C1]
DOI10.1111/j.1538-7836.2011.04220.x
CitationsScopus - 16Web of Science - 16
Co-authorsRick Thorne
2011Golledge J, Clancy P, Maguire JM, Lincz L, Koblar S, 'The role of tenascin C in cardiovascular disease', Cardiovascular Research, 92 19-28 (2011) [C1]
DOI10.1093/cvr/cvr183
CitationsScopus - 17Web of Science - 20
Co-authorsJane Maguire
2011Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: A novel finding', Journal of Stroke and Cerebrovascular Diseases, 20 134-144 (2011) [C1]
DOI10.1016/j.jstrokecerebrovasdis.2009.10.011
CitationsScopus - 21Web of Science - 20
Co-authorsRodney Scott, Chris Levi, Jane Maguire, John Attia
2011McGettigan P, Lincz L, Attia JR, McElduff P, Bissett L, Peel R, et al., 'The risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxygenase-2 gene', British Journal of Clinical Pharmacology, 72 707-714 (2011) [C1]
DOI10.1111/j.1365-2125.2011.03957.x
CitationsScopus - 6Web of Science - 6
Co-authorsJohn Attia, Roseanne Peel, Mddah01, Barrie Stokes
2010Isbister GK, Woods D, Alley S, O'Leary MA, Seldon M, Lincz L, 'Endogenous thrombin potential as a novel method for the characterization of procoagulant snake venoms and the efficacy of antivenom', Toxicon, 56 75-85 (2010) [C1]
DOI10.1016/j.toxicon.2010.03.013
CitationsScopus - 17Web of Science - 16
Co-authorsGeoff Isbister
2010Enjeti A, Lincz L, Scorgie FE, Seldon MR, 'Circulating microparticles are elevated in carriers of Factor V Leiden', Thrombosis Research, 126 250-253 (2010) [C1]
DOI10.1016/j.thromres.2009.11.019
CitationsScopus - 6Web of Science - 6
2010De Bock CE, Garg ML, Scott NM, Sakoff JA, Scorgie FE, Ackland S, Lincz L, 'Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo', Pharmacogenomics Journal, 1-8 (2010) [C1]
DOI10.1038/tpj.2010.43
CitationsScopus - 7Web of Science - 7
Co-authorsStephen Ackland, Jennette Sakoff, Manohar Garg
2009Isbister GK, Scorgie FE, Seldon MR, Lincz L, 'Clinical relevance of brown snake (Pseudonaja spp) factor V escaping hemostatic regulation', Blood, 114 2563 (2009) [C3]
DOI10.1182/blood-2009-06-227306
CitationsScopus - 1
Co-authorsGeoff Isbister
2009Lincz L, Gupta SA, Wratten C, Kilmurray J, Nash S, Seldon M, et al., 'Thrombin generation as a predictor of radiotherapy induced skin erythema', Radiotherapy and Oncology, 90 136-140 (2009) [C1]
DOI10.1016/j.radonc.2008.10.002
CitationsScopus - 2Web of Science - 1
2008Lincz L, Mudge L-M, Scorgie FE, Sakoff JA, Hamilton C, Seldon MR, 'Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the [beta symbol] deletion variant', Neoplasia, 10 1131-1137 (2008) [C1]
DOI10.1593/neo.08644
CitationsScopus - 21Web of Science - 20
Co-authorsJennette Sakoff
2008Enjeti AK, Lincz L, Seldon MR, 'Bio-maleimide as a generic stain for detection and quantitation of microparticles', International Journal of Laboratory Hematology, 30 196-199 (2008) [C1]
DOI10.1111/j.1751-553x.2007.00937.x
CitationsScopus - 13Web of Science - 12
2008Maguire JM, Thakkinstian A, Sturm J, Levi CR, Lincz L, Parsons MW, et al., 'Polymorphisms in platelet glycoprotein 1b [alpha] and factor VII and risk of ischemic stroke', Stroke, 39 1710-1716 (2008) [C1]
DOI10.1161/strokeaha.107.507228
CitationsScopus - 24Web of Science - 23
Co-authorsChris Levi, Mark Parsons, John Attia, Jane Maguire
2008Enjeti AK, Lincz L, Seldon MR, 'Microparticles in health and disease', Seminars in Thrombosis and Haemostasis, 34 683-692 (2008) [C1]
DOI10.1055/s-0028-1104547
CitationsScopus - 40Web of Science - 41
2007Lincz L, Adams MJ, Scorgie FE, Thom J, Baker RI, Seldon M, 'Polymorphisms of the tissue factor pathway inhibitor gene are associated with venous thromboembolism in the antiphospholipid syndrome and carriers of factor V Leiden', Blood Coagulation & Fibrinolysis, 18 559-564 (2007) [C1]
DOI10.1097/MBC.0b013e3281eec977
CitationsScopus - 10Web of Science - 10
2007Attia JR, Thakkinstian A, Wang Y, Lincz L, Parsons MW, Sturm J, et al., 'The PAI-1 4G/5G gene polymorphism and ischemic stroke: An association study and meta-analysis', Journal of Stroke and Cerebrovascular Diseases, 16 173-179 (2007) [C1]
DOI10.1016/j.jstrokecerebrovasdis.2007.03.002
CitationsScopus - 31
Co-authorsJohn Attia, Rodney Scott, Mark Parsons, Chris Levi
2007Au GG, Lincz L, Enno A, Shafren DR, 'Oncolytic Coxsackievirus A21 as a novel therapy for multiple myeloma', British Journal of Haematology, 137 133-141 (2007) [C1]
DOI10.1111/j.1365-2141.2007.06550.x
CitationsScopus - 21Web of Science - 18
Co-authorsGough Au
2007Lincz L, Scorgie FE, Garg MB, Ackland S, 'Identification of a novel single nucleotide polymorphism in the second tandem repeat sequence of the thymidylate synthase 2R allele', International Journal of Cancer, 120 1930-1934 (2007) [C1]
DOI10.1002/ijc.22568
CitationsScopus - 29Web of Science - 26
Co-authorsStephen Ackland
2007Lincz L, Scorgie FE, Garg ML, Ackland S, 'Reply to the letter to the editor 'Classification of thymidylate synthase gene enhancer region polymorphisms'', International Journal of Cancer, 121 2581-2582 (2007) [C3]
DOI10.1002/ijc.22987
Co-authorsStephen Ackland, Manohar Garg
2007Enjeti AK, Lincz L, Seldon M, 'Detection and measurement of microparticles: An evolving research tool for vascular biology', Seminars in Thrombosis and Hemostasis, 33 771-779 (2007) [C1]
DOI10.1055/s-2007-1000369
CitationsScopus - 71Web of Science - 69
2007Lincz L, Scorgie FE, Robertson R, Enno A, 'Genetic variations in benzene metabolism and susceptibility to multiple myeloma', Leukemia Research, 31 759-763 (2007) [C1]
DOI10.1016/j.leukres.2006.07.012
CitationsScopus - 12Web of Science - 10
2006Lincz L, Lonergan A, Scorgie FE, Rowlings PA, Gibson R, Lawrie A, Seldon MR, 'Endogenous thrombin potential for predicting risk of venous thromboembolism in carriers of Factor V Leiden', Pathophysiology of Haemostatis and Thrombosis, 35 435-439 (2006) [C1]
DOI10.1159/000102050
CitationsScopus - 11Web of Science - 13
2004Lincz L, Scorgie F, Sakoff J, Fagan K, Ackland S, Enno A, 'Telomere length predicts neutrophil recovery in absence of G-CSF after autologous peripheral blood stem cell transplantation', Bone Marrow Transplant, 34 439-445 (2004) [C1]
DOI10.1038/sj.bmt.1704607
CitationsScopus - 3Web of Science - 3
Co-authorsJennette Sakoff, Stephen Ackland
2004Lincz L, Kerridge I, Scorgie FE, Bailey M, Enno A, Spencer A, 'Xenobiotic gene polymorphisms and susceptibility to multiple myeloma', Haematologica, 89 628-629 (2004) [C3]
CitationsScopus - 31Web of Science - 27
2003Lincz L, Scorgie FE, Kerridge I, Potts R, Spencer A, Enno A, 'Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma', British Journal of Haematology, 120 1051-1054 (2003) [C1]
DOI10.1046/j.1365-2141.2003.04220.x
CitationsScopus - 51Web of Science - 49
2002Sakoff J, De Waal E, Garg M, Denham J, Scorgie F, Enno A, et al., 'Telomere Length in Haemopoietic Stem Cells can be Determined from that of Mononuclear Blood Cells or Whole Blood', Leukemia and Lymphoma, 43(10) 2017-2020 (2002) [C1]
CitationsScopus - 21Web of Science - 22
Co-authorsStephen Ackland, Jennette Sakoff
2002Kerridge I, Lincz L, Scorgie F, Hickey D, Granter N, Spencer A, 'Association between xenobiotic gene polymorphisms and non-Hodgkin's lymphoma risk', BRITISH JOURNAL OF HAEMATOLOGY, 118 477-481 (2002)
DOI10.1046/j.1365-2141.2002.03606.xAuthor URL
CitationsScopus - 70Web of Science - 61
2002Kerridge I, Lincz LF, Scorgie FE, Granter N, Hickey D, Enno A, Spencer A, 'Xenobiotic enzyme polymorphisms and lymphoma susceptibility', Br. J. Haemtol, 118 477-481 (2002) [C1]
2001Lincz L, Yeh T-X, Spencer A, 'TRAIL-induced eradication of primary tumour cells from multiple myeloma patient bone marrows is not related to TRAIL receptor expression or prior chemotherapy', Leukemia, 15 1650-1657 (2001) [C1]
CitationsScopus - 50Web of Science - 56
2001Lincz L, Crooks RL, Way SL, Granter N, Spencer A, 'Tumour Kinetics in Multiple Myeloma Before, During, and After Treatment', Leukemia & Lymphoma, 40 373-384 (2001) [C1]
CitationsScopus - 4Web of Science - 3
2000Lincz LF, Yeh TH, Enno A, Spencer A, 'Variations in TRAIL-induced apoptosis of freshly obtained myeloma cells are not related to TRAIL receptor expression or prior chemotherapy.', BLOOD, 96 162A-162A (2000)
Author URL
2000Lincz LF, Yeh T-H, Enno A, Spencer A, 'Variations in trail-induced apoptosis of freshly obtained myeloma cells are not related to trail receptor expression or prior chemotherapy', Blood, 96 (2000)

TNF-related apoptosis-inducing ligand (TRAIL) is a potent and selective inducer of apoptosis in malignant cells. Using the combined methods of Annexin V labelling, cell cycle analysis and DNA electrophoresis, we have demonstrated susceptibility to TRAILinduced apoptosis in the human multiple myeloma (MM) cell lines NCI H929, RPMI 8226, OPM-2 and LP-1, while the lymphoblastoid cell lines (LCL) U266 and MC/CAR were resistant. Two different forms of TRAIL were tested: purified human recombinant soluble TRAIL (s-TRAIL; residues 114-281; Biomol, Plymouth Meeting, PA) demonstrated maximal apoptosis induction at 1 u,g/ml in sensitive cell lines, while a leucine zipper construct (LZ-TRAIL; Immunex Corp., Seattle, WA) was equally effective when used at a concentration of 500 ng/ml. BM samples obtained from 16 MM patients at various stages of disease were incubated for 24 hours with or without either 2u,g/tnl sTRAIL (n = 8) or lug/ml LZ-TRAIL (n = 8). The percentage of viable MM cells was then determined by flow cytometric quantification of anti-CD138 stained cells and the relative TRAIL-induced reduction in MM cells calculated using the formula: [(Untreated)-(TRAlLTreated)]/Untreated x 100%. BM samples from 6 of 16 (38%) patients demonstrated a significant ( 10%) relative reduction in the number of MM cells following TRAIL incubation (range: 11% to 59%). This did not correlate with prior therapy, as a reduction was seen in 2/5 samples obtained from patients at diagnosis, 2/5 samples following standard-dose chemotherapy and 2/6 samples following high-dose chemotherapy. The relationship between TRAIL-receptor expression (TRAIL-R1, R2, R3, R4 and OPG) and TRAILinduced apoptosis was examined in 2 sensitive (NCI H929, RPMI 8226) and the 2 resistant cell lines and 5 MM BM samples (2 sensitive, 3 resistant) utilising RT-PCR and surface immunostaining of purified MM cells. Concordance between TRAIL-receptor mRNA detection and cell surface expression was shown in all cell lines. Furthermore, all cell lines and patient samples demonstrated mRNA expression for the intracellular deathdomain containing TRAIL-R1. Variable expression of the 2 decoy (TRAIL-R3 and R4) and soluble (OPG) receptors was seen and this did not correlate with TRAIL sensitivity. We conclude that MM cell expression of death effector receptors for TRAIL is insufficient to confer sensitivity to TRAIL-induced apoptosis but that in a significant minority of patients, irrespective of prior therapy, MM cells are sensitive to TRAIL-induced apoptosis.

1998Lincz L, 'Deciphering the apoptotic pathway: All roads lead to death', Immunology & Cell Biology, 76 1-19 (1998) [C1]
CitationsScopus - 89Web of Science - 90
1997Lincz L, Buret A, Burns GF, 'Formation of spheroid structures in a human colon carcinoma cell line involves a complex series of intercellular rearrangements', Differentiation, 61 261-274 (1997) [C1]
CitationsScopus - 12Web of Science - 10
1996Dorahy DJ, Lincz LF, Meldrum CJ, Burns GF, 'Biochemical isolation of a membrane microdomain from resting platelets highly enriched in the plasma membrane glycoprotein CD36', BIOCHEMICAL JOURNAL, 319 67-72 (1996)
Author URL
CitationsScopus - 101Web of Science - 105
1995BATES RC, LINCZ LF, BURNS GF, 'INVOLVEMENT OF INTEGRINS IN CELL-SURVIVAL', CANCER AND METASTASIS REVIEWS, 14 191-203 (1995)
DOI10.1007/BF00690291Author URL
CitationsScopus - 79Web of Science - 81
Show 53 more journal articles

Conference (37 outputs)

YearCitationAltmetricsLink
2014Prawira A, Garg MB, Sakoff JA, Lincz LF, Adler K, Scorgie FE, Ackland SP, 'FACTORS PREDICTING RESPONSE AND SURVIVAL IN COLORECTAL CANCER PATIENTS RECEIVING ADJUVANT 5-FLUOROURACIL CHEMOTHERAPY: 10-YEAR FOLLOW-UP OF A PROSPECTIVE PATIENT COHORT', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Author URL
Co-authorsJennette Sakoff, Stephen Ackland
2013Enjeti A, D'Cruz A, Seldon M, Lincz L, 'Circulating microparticle number and function vary with age: a study of 120 healthy blood donors', JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013) [E3]
Author URL
2012Phang M, Lincz L, Garg ML, 'Efficacy of EPA- and DHA- rich oils on platelet function in healthy men and women', Abstracts. International Conference and Exhibition on Nutraceuticals and Functional Foods, Hawaii, USA (2012) [E3]
Co-authorsManohar Garg
2012Phang M, Lincz L, Garg ML, 'Eicosapentaenoic acid versus docosahexaenoic acid rich fish oils: Effect on platelet physiological response', Conference Handbook. Food Structures, Digestion and Health Conference, Palmerston North, NZ (2012) [E3]
Co-authorsManohar Garg
2012Lincz L, Johnston CI, Scorgie FE, O'Leary MA, Prasad R, Seldon MR, et al., 'Comparative sensitivity of different commercially available aPTT reagents to a clinically relevant 'coagulation inhibitor'', HAA 2012: 2012 Co-Joint Scientific Meeting. ASTH Posters, Melbourne (2012) [E3]
Co-authorsGeoff Isbister
2012Scorgie FE, Maduwage KP, Lincz L, Shahmy S, Mohamed F, Seldon MR, Isbister GK, 'Comparison of the haemostatic effects of three different procoagulant snake venoms in human envenoming', HAA 2012: 2012 Co-Joint Scientific Meeting. ASTH Posters, Melbourne (2012) [E3]
Co-authorsGeoff Isbister
2012Lincz L, 'The nature and origin of circulating CD36 in type 2 diabetes: A role for microparticles', HAA 2012: 2012 Co-Joint Scientific Meeting. Abstracts, Melbourne (2012) [E3]
2012Phang M, Lincz L, Garg ML, 'Omega-3 polyunsaturated fatty acids and platelet function: Sex dependence', Indian Journal of Hypertension, Mumbai, India (2012) [E3]
Co-authorsManohar Garg
2012Phang M, Lincz L, Seldon MR, Garg ML, 'Differential effects of eicosapentaenoic and docosahexaenoic acids on platelet aggregation and hemostatic markers', Proceedings of the Nutrition Society of Australia, Wollongong, NSW (2012) [E3]
Co-authorsManohar Garg
2012Sakoff JA, Garg MB, Lincz L, Adler K, Scorgie FE, Ackland S, 'Predicting chemotherapy-induced toxicity in cancer patients from peripheral blood telomere length', European Journal of Cancer, Barcelona, Spain (2012) [E3]
Co-authorsStephen Ackland, Jennette Sakoff
2011Maguire JM, Holliday EG, Sturm J, Golledge J, Lewis M, Koblar S, et al., 'Australian stroke genetics collaborative: Genetic associations with ischaemic stroke functional outcome', International Journal of Stroke, Adelaide, SA (2011) [E3]
Co-authorsRodney Scott, Liz Holliday, Chris Levi, John Attia, Jane Maguire, Mark Parsons, Pablo Moscato
2011Phang M, Lincz L, Garg ML, 'Gender specific effects of long-term dietary EPA and DHA supplementation in platelet aggregation in healthy human subjects', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsManohar Garg
2011Alkhatatbeh MJ, Mhaidat NM, Enjeti AK, Lincz LF, Thorne RF, 'Circulating plasma CD36+microparticles as a marker of type 2 diabetes and its complications', Clinical Biochemistry, Mashhad, Iran (2011) [E3]
Co-authorsRick Thorne
2011Ardjmand Ghahestani A, De Bock CE, Molloy TJ, Bone SM, Johnstone DM, Campbell DM, et al., 'Altered expression of Fat1 cadherin, a novel tumor marker for acute lymphoblastic leukemia', Clinical Biochemistry, Mashhad, Iran (2011) [E3]
Co-authorsRick Thorne
2010Phang M, Lincz L, Garg ML, 'Gender specific role of n-3PUFA to inhibit microparticle activity in healthy humans', 15th World Congress on Clinical Nutrition, El Sokhna, Egypt (2010) [E3]
Co-authorsManohar Garg
2010Sakoff JA, Garg M, Adler K, Scorgie FE, Lincz L, Ackland S, 'Telomere length in peripheral blood mononuclear cells (PBMNC) predicts for leukopenia, neutropenia and mucositis in colorectal cancer patients treated with 5FU', AACR 101st Annual Meeting 2010. Abstracts, Washington, DC (2010) [E3]
Co-authorsStephen Ackland, Jennette Sakoff
2010Phang M, Sinclair AJ, Lincz L, Garg ML, 'Omega-3 polyunsaturated fatty acis inhibit platelet-derived microparticle activiity in healthy human subjects', APSAVD 2010 Congress. AAS 2010 Annual Scientific Meeting. Abstract Book, Cairns, QLD (2010) [E3]
Co-authorsManohar Garg
2010Lincz L, Scorgie F, Phang M, Garg ML, Enjeti A, Seldo M, 'Variability in platelet microparticle profile and aggregation in healthy males and females', Annual Scientific Meeting of the Haematology Society of Australia and New Zealand. Handbook and Program, Auckland, New Zealand (2010) [E3]
Co-authorsManohar Garg
2010Phang M, Lincz L, Sinclair AJ, Garg ML, 'Platelet-derived microparticle activity is inhibited by omega-3 fatty acid supplementation', Proceedings of the Nutrition Society of Australia, Perth (2010) [E3]
Co-authorsManohar Garg
2010Sakoff JA, Garg M, Adler K, Scorgie FE, Lincz L, Ackland S, 'Short telomeres in PBMNC predicts for haematological toxicity in colorectal cancer patients treated with 5FU', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Co-authorsJennette Sakoff, Stephen Ackland
2010Maguire JM, Thakkinstian A, Levi CR, Lincz L, Bissett KE, Sturm J, et al., 'Genetic influences on ischemic stroke 90-day functional outcome: A novel association', Circulation, Beijing (2010) [E3]
Co-authorsJane Maguire, Rodney Scott, Chris Levi, John Attia
2009Lincz L, Woods D, Alley S, O'Leary MA, Seldon MR, Isbister GK, 'Endogenous thrombin potential as a novel method for characterisation of procoagulant snake venoms', Journal of Thrombosis and Haemostasis, Boston, MA (2009) [E3]
DOI10.1111/j.1538-7836.2009.03473_2.x
Co-authorsGeoff Isbister
2009Isbister GK, Scorgie F, Brown SGA, O'Leary MA, Seldon MR, Lincz L, 'Coagulation factor deficiencies associated with venom induced consumption coagulopathy in Australian snake envenoming', Clinical Toxicology, Stockholm, Sweden (2009) [E3]
CitationsWeb of Science - 4
Co-authorsGeoff Isbister
2009Henry D, Lincz L, Attia JR, McElduff P, Bisset L, Peel R, et al., 'Polymorphisms in two regions of the cyclo-oxygenase-2 gene associated with variation in risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors', Basic & Clinical Pharmacology & Toxicology, Edinburgh, UK (2009) [E3]
DOI10.1111/j.1742-7843.2009.00436.x
Co-authorsJohn Attia, Roseanne Peel
2009Phang M, Sinclair AJ, Lincz L, Garg ML, 'Differential effects of dietary EPA or DHA supplementation on platelet aggregation in healthy male and female subjects', Atherosclerosis Society Annual Scientific Meeting 2009: Meeting Book, Melbourne, VIC (2009) [E3]
Co-authorsManohar Garg
2009Phang M, Sinclair AJ, Lincz L, Garg ML, 'Differential effects of a single oral dose of EPA or DHA rich fish oil on platelet aggregation in health human subjects', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsManohar Garg
2009Maguire J, Thakkinstian A, Attia JR, Lincz L, Bisset L, Sturm J, et al., 'Impact of COX-2 RS5275, RS20417 and GPIIIA RS5918 polymorphisms on 90 day ischaemic stroke functional outcome: A novel association', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
DOI10.1159/000221772
Co-authorsChris Levi, John Attia, Rodney Scott
2009Henry D, Lincz L, Attia J, McElduff P, Bisset L, Peel R, et al., 'Polymorphisms in Two Regions of the Cyclo-Oxygenase-2 Gene Associated with Variation in Risk of Coronary Thrombosis with Cyclo-Oxygenase-2 Inhibitors', PHARMACOEPIDEMIOLOGY AND DRUG SAFETY (2009) [E3]
Author URL
Co-authorsJohn Attia, Roseanne Peel
2008Enjeti A, Lincz L, Scorgie F, Seldon M, 'Miniature microparticles measuring less than 0.1 um exist in human plasma and contribute to procoagulant activity', International Journal of Laboratory Hematology, Sydney, NSW (2008) [E3]
2008Zaunders G, Thambar ST, Zhang H, Lincz L, Rowlings PA, 'Laboratory aspects of autologous marrow stem cells used to treat chronic myocardial ischaemia by direct intramyocardial injection', International Journal of Laboratory Hematology, Sydney, NSW (2008) [E3]
2008Enjeti A, Scorgie FE, Lincz L, Brown S, Isbister GK, Seldon MR, 'Circulating microparticles in snake bite patients with microangiopathy', 50th ASH Annual Meeting and Exposition. Online Program and Abstracts, San Francisco, CA (2008) [E3]
Co-authorsGeoff Isbister
2008Lincz L, Gupta SA, Wratten CR, Kilmurray J, Nash S, Seldon M, et al., 'Thrombin generation as a predictor of radiotherapy induced skin erythema', HAA 2008 HSANZ ANZSBT ASTH: 2008 Annual Scientific Meeting: Abstracts, Perth, WA (2008) [E3]
2008Lincz L, Woods D, Alley S, O'Leary MA, Seldon MR, Isbister GK, 'Endogenous thrombin potential (ETP) as a novel method for characterization of procoagulant snake venoms', HAA 2008 HSANZ ANZSBT ASTH: 2008 Annual Scientific Meeting: Abstracts, Perth, WA (2008) [E3]
Co-authorsGeoff Isbister
2007Maguire J, Sturm J, Attia JR, Whyte S, Bisset L, Lincz L, et al., 'A case-control genetic association study to examine platelet glycoprotein polymorphisms and ischaemic stroke risk', Internal Medicine Journal, Perth, Australia (2007) [E3]
Co-authorsJohn Attia, Chris Levi, Mark Parsons
2003McRae SJ, Lincz L, Scorgie F, Gibson R, Seldon M, 'The factor V Asp2194Gly polymorphism linked to the HR2 haplotype is associated with decreased factor V levels.', BLOOD 102 Meeting Abstract (2003) [E3]
2003Lincz LF, Kerridge I, Scorgie F, Bailey M, Enno A, Spencer A, 'Xenobiotic gene polymorphisms alter susceptibility to multiple myeloma.', BLOOD, San Diego, CA (2003)
Author URL
2002Lincz LF, Enno A, 'Thalidomide induced alterations in multiple myeloma cell surface receptor expression do not affect adhesion to bone marrow stroma or correlate with VEGF secretion in vitro.', BLOOD, PHILADELPHIA, PA (2002)
Author URL
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Grants and Funding

Summary

Number of grants21
Total funding$2,646,890

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,031,671

Helping stroke physicians choose who to thrombolyse - the "Targeting Optimal Thrombolysis Outcomes" (TOTO) study$1,031,671

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Liz Holliday, Professor John Attia, Associate Professor Vincent Thijs, Dr Simon Koblar, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jane Maguire, Doctor Lisa Lincz
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400237
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20141 grants / $50,000

What is different about red blood cells in people with type 2 diabetes?$50,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Lisa Lincz, Doctor Rick Thorne
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401416
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20132 grants / $20,000

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
SchemeNear Miss Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300475
Type Of FundingInternal
CategoryINTE
UONY

The genetic determinants of brain haemorrhage associated with stroke thrombolysis$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Chris Levi, Professor John Attia, Doctor Liz Holliday, Dr Simon Koblar, Professor Rodney Scott, Conjoint Associate Professor Jonathan Sturm, Associate Professor Jonathan Rosand, Doctor Lisa Lincz, Associate Professor Jane Maguire
SchemeNear Miss
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300704
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20122 grants / $163,394

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200555
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Establishment of Fat1 cadherin as biomarker and unique target for anti-cancer therapy in paediatric acute lymphoblastic leukaemia$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Rick Thorne, Doctor Charles De Bock, Doctor Lisa Lincz
SchemeResearch Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200222
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20111 grants / $24,800

How chronic psychological distress leads to premature aging$24,800

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Eugene Nalivaiko, Doctor Lisa Lincz
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000986
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20101 grants / $98,000

Pathogenic Function of Plasma CD36 Mircroparticles in Mediating Complications of Type 2 Diabetes$98,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Rick Thorne, Doctor Lisa Lincz
SchemeProject Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900121
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20093 grants / $1,143,400

Australian stroke genetics collaborative - Genome-wide association study in ischaemic stroke$1,108,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Chris Levi, Conjoint Associate Professor Jonathan Sturm, Professor John Attia, Professor Rodney Scott, Doctor Lisa Lincz, Dr Simon Koblar, Professor Pablo Moscato
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0188856
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Identification of leukaemic stem cells based upon their expression of a novel surface marker, Fat1$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Rick Thorne, Doctor Lisa Lincz
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189791
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Vascular Ischaemia Study$10,400

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Chris Levi, Professor John Attia, Professor Rodney Scott, Doctor Michael Seldon, Doctor Lisa Lincz, Conjoint Associate Professor Jonathan Sturm
SchemeResearch Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0900120
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20083 grants / $40,125

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188545
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Biogenesis of circulating plasma microparticles in the metabolic syndrome$8,450

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Rick Thorne, Doctor Lisa Lincz
SchemePilot Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189072
Type Of FundingInternal
CategoryINTE
UONY

Biogenesis of circulating plasma microparticles in the metabolic syndrome$8,450

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Rick Thorne, Doctor Lisa Lincz
SchemePilot Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189385
Type Of FundingInternal
CategoryINTE
UONY

20071 grants / $20,000

A novel adhesive target involved in the survival of leukaemia cells$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Rick Thorne, Doctor Lisa Lincz
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187243
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20061 grants / $11,000

Overcoming radiation resistance in malignant melanoma$11,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Lisa Lincz, Doctor Jennette Sakoff
SchemeProject Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186528
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20032 grants / $13,000

Investigation of mutant p53 and CD40 expression in multiple myeloma cells and response to thalidomide$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Lisa Lincz
SchemeEarly Career Researcher Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182860
Type Of FundingInternal
CategoryINTE
UONY

PULSE Education Prize$3,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Lisa Lincz
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182735
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20011 grants / $10,000

Predicting bone marrow regeneration in cancer patients through the use of telomere quantitative (Q)-FISH$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Lisa Lincz, Doctor Jennette Sakoff
SchemeLions Club of Stroud
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181502
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

20002 grants / $21,500

Influence of Haematopoetic stem cell telorase activity on bone marrow recovery following myoablative therapy.$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Lisa Lincz, Ms Kerry Fagan, Doctor Jennette Sakoff
SchemeResearch Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0180171
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Newcastle and Hunter Junior Chamber Special Commendation Prize.$1,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Lisa Lincz
SchemeResearch Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0180172
Type Of FundingContract - Aust Non Government
Category3AFC
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Genomics and Pharmacogenomics of Stroke
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2011Investigating the Role of Microparticles in Vascular Biology and Haemostasis
General Medicine, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2013Biogenesis of Plasma CD36+Microparticles in Human Diabetes and the Metabolic Syndrome
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013Differential Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Platelet Aggregation and Hemostatic Variables in Healthy Male Versus Female Subjects
Medical Science, Faculty of Health and Medicine
Co-Supervisor
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Dr Lisa Lincz

Position

Conjoint Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Emaillisa.lincz@newcastle.edu.au
Phone(02) 4921 1844
Mobile0403492243
Fax(02) 4960 2136

Office

Room4.28
BuildingMater Hospital Level 4 - New Med 2
LocationCalvary Mater Newcastle, Waratah

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