2023 |
Revelas M, Thalamuthu A, Zettergren A, Oldmeadow C, Najar J, Seidu NM, et al., 'High polygenic risk score for exceptional longevity is associated with a healthy metabolic profile.', Geroscience, 45 399-413 (2023) [C1]
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Nova |
2023 |
Reay WR, Clarke E, Eslick S, Riveros C, Holliday EG, McEvoy MA, et al., 'Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension.', Circulation, (2023) [C1]
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2023 |
Forwood C, Ashton K, Zhu Y, Zhang F, Dias KR, Standen K, et al., 'Integration of EpiSign, facial phenotyping, and likelihood ratio interpretation of clinical abnormalities in the re-classification of an ARID1B missense variant', American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, 193 (2023) [C1]
Heterozygous ARID1B variants result in Coffin¿Siris syndrome. Features may include hypoplastic nails, slow growth, characteristic facial features, hypotonia, hypertrichosis, and s... [more]
Heterozygous ARID1B variants result in Coffin¿Siris syndrome. Features may include hypoplastic nails, slow growth, characteristic facial features, hypotonia, hypertrichosis, and sparse scalp hair. Most reported cases are due to ARID1B loss of function variants. We report a boy with developmental delay, feeding difficulties, aspiration, recurrent respiratory infections, slow growth, and hypotonia without a clinical diagnosis, where a previously unreported ARID1B missense variant was classified as a variant of uncertain significance. The pathogenicity of this variant was refined through combined methodologies including genome-wide methylation signature analysis (EpiSign), Machine Learning (ML) facial phenotyping, and LIRICAL. Trio exome sequencing and EpiSign were performed. ML facial phenotyping compared facial images using FaceMatch and GestaltMatcher to syndrome-specific libraries to prioritize the trio exome bioinformatic pipeline gene list output. Phenotype-driven variant prioritization was performed with LIRICAL. A de novo heterozygous missense variant, ARID1B p.(Tyr1268His), was reported as a variant of uncertain significance. The ACMG classification was refined to likely pathogenic by a supportive methylation signature, ML facial phenotyping, and prioritization through LIRICAL. The ARID1B genotype¿phenotype has been expanded through an extended analysis of missense variation through genome-wide methylation signatures, ML facial phenotyping, and likelihood-ratio gene prioritization.
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2022 |
Phung J, Wang CA, Reeders J, Chan EC, Riveros C, Zakar T, et al., 'Preterm labor is a distinct process from term labor following computational analysis of human myometrium', American Journal of Obstetrics and Gynecology, 226 106.e1-106.e16 (2022) [C1]
Background: The onset of the term human parturition involves myometrial gene expression changes to transform the uterus from a quiescent to a contractile phenotype. It is uncertai... [more]
Background: The onset of the term human parturition involves myometrial gene expression changes to transform the uterus from a quiescent to a contractile phenotype. It is uncertain whether the same changes occur in the uterus during preterm labor. Objective: This study aimed to compare the myometrial gene expression between term and preterm labor and to determine whether the presence of acute clinical chorioamnionitis or twin gestation affects these signatures. Study Design: Myometrial specimens were collected during cesarean delivery from the following 7 different groups of patients: term not in labor (n=31), term labor (n=13), preterm not in labor (n=21), preterm labor with acute clinical chorioamnionitis (n=6), preterm labor with no acute clinical chorioamnionitis (n=9), twin preterm not in labor (n=8), and twin preterm labor with no acute clinical chorioamnionitis (n=5). RNA was extracted, reverse transcribed and quantitative polymerase chain reactions were performed on 44 candidate genes (with evidence for differential expression in human term labor) using the Fluidigm platform. Computational analysis was performed using 2-class unpaired Wilcoxon tests and principal component analysis. Results: Computational analysis revealed that gene expression in the preterm myometrium, irrespective of whether in labor or not in labor, clustered tightly and is clearly different from the term labor and term not-in-labor groups. This was true for both singleton and twin pregnancies. Principal component analysis showed that 57% of the variation was explained by 3 principal components. These 44 genes interact in themes of prostaglandin activity and inflammatory signaling known to be important during term labor, but are not a full representation of the myometrium transcriptional activity. Conclusion: The myometrial contractions associated with preterm labor are associated with a pattern of gene expression that is distinct from term labor. Therefore, preterm labor may be initiated by a different myometrial process or processes outside the myometrium.
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Nova |
2022 |
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, et al., 'A saturated map of common genetic variants associated with human height', NATURE, 610 704-+ (2022) [C1]
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Nova |
2022 |
Fricker M, Qin L, Sánchez-Ovando S, Simpson JL, Baines KJ, Riveros C, et al., 'An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype.', Allergy, 77 1204-1215 (2022) [C1]
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Nova |
2022 |
Tyagi S, Chan E-C, Barker D, McElduff P, Taylor KA, Riveros C, et al., 'Transcriptomic analysis reveals myometrial topologically associated domains linked to the onset of human term labour.', Mol Hum Reprod, 28 (2022) [C1]
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Nova |
2021 |
Hendrickx W, Riveros C, Askim T, Bussmann JBJ, Callisaya ML, Chastin SFM, et al., 'An Exploration of Sedentary Behavior Patterns in Community-Dwelling People with Stroke: A Cluster-Based Analysis', Journal of Neurologic Physical Therapy, 45 221-227 (2021) [C1]
Background and Purpose: Long periods of daily sedentary time, particularly accumulated in long uninterrupted bouts, are a risk factor for cardiovascular disease. People with strok... [more]
Background and Purpose: Long periods of daily sedentary time, particularly accumulated in long uninterrupted bouts, are a risk factor for cardiovascular disease. People with stroke are at high risk of recurrent events and prolonged sedentary time may increase this risk. We aimed to explore how people with stroke distribute their periods of sedentary behavior, which factors influence this distribution, and whether sedentary behavior clusters can be distinguished? Methods: This was a secondary analysis of original accelerometry data from adults with stroke living in the community. We conducted data-driven clustering analyses to identify unique accumulation patterns of sedentary time across participants, followed by multinomial logistical regression to determine the association between the clusters, and the total amount of sedentary time, age, gender, body mass index (BMI), walking speed, and wake time. Results: Participants in the highest quartile of total sedentary time accumulated a significantly higher proportion of their sedentary time in prolonged bouts (P < 0.001). Six unique accumulation patterns were identified, all of which were characterized by high sedentary time. Total sedentary time, age, gender, BMI, and walking speed were significantly associated with the probability of a person being in a specific accumulation pattern cluster, P < 0.001 - P = 0.002. Discussion and Conclusions: Although unique accumulation patterns were identified, there is not just one accumulation pattern for high sedentary time. This suggests that interventions to reduce sedentary time must be individually tailored. Video Abstract available for more insight from the authors (see the Video Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A343).
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Nova |
2021 |
Reay WR, El Shair S, Geaghan MP, Riveros C, Holliday EG, McEvoy MA, et al., 'Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function', ELIFE, 10 (2021) [C1]
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Nova |
2020 |
Reay W, Shair SE, Geaghan M, Riveros C, Holliday E, McEvoy M, et al., 'Genetically informed precision drug repurposing for lung function and implications for respiratory infection (2020)
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2020 |
Benson P, Kim JY, Riveros C, Camp A, Johnstone DM, 'Elucidating the time course of the transcriptomic response to photobiomodulation through gene co-expression analysis', JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 208 (2020) [C1]
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Nova |
2019 |
Lawson J, McGill A, Meares H, Coleman H, Riveros C, Martin A, 'Wound protectors for improved exposure in open hernia repair', Hernia, 23 1215-1219 (2019)
Introduction: Achieving adequate surgical exposure is fundamental to good surgical practice. Traditionally, in the repair of ventral and open inguinal hernias, this has been accom... [more]
Introduction: Achieving adequate surgical exposure is fundamental to good surgical practice. Traditionally, in the repair of ventral and open inguinal hernias, this has been accomplished with the aid of self-retaining retractors or by extending the incision length. We propose that using disposable wound protectors, surgical exposure will be improved for a given incision length in the repair of ventral and open inguinal hernias, compared to traditional methods. Method: Through the use of an animal tissue model, we compared incisions of varying lengths and measured the dimensions of the exposure achieved with disposable wound protectors (Alexis¿) and a Mollison self-retainer. We calculated the surface area and, therefore, exposure gained using the specified wound retraction devices and compared the results. Results: The average superficial surface area of wound with a self-retainer compared to the small and extra-small disposable wound protector was 2.65¿cm2 vs 2.27¿cm2 (small) and 2.2¿cm2 (extra-small) for 2¿cm incision length, 3.6¿cm2 vs 4.93¿cm2 and 4.2¿cm2 for 3¿cm incision length, 5.19¿cm2 vs 8.25¿cm2 and 6.27¿cm2 for 4¿cm incision length, 6.17¿cm2 vs 12.25¿cm2 and 9.07¿cm2 for 5¿cm incision length, and 8.75¿cm2 vs 16.73¿cm2 and 10.78¿cm2 for 6¿cm incision length [p = 0.038 (small) and p = 0.049 (extra-small)]. Our results show a statistically significant increase in surface area of a wound for each incision length when a disposable wound protector was used for exposure, compared to a self-retainer. Conclusion: Our results demonstrate that the use of disposable wound protectors provides superior surgical exposure for a given incision length compared to traditional techniques in the repair of ventral and open inguinal hernia repairs.
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2019 |
Hyde LL, Boyes AW, Mackenzie LJ, Leigh L, Oldmeadow C, Riveros C, Sanson-Fisher R, 'Electronic Health Literacy Among Magnetic Resonance Imaging and Computed Tomography Medical Imaging Outpatients: Cluster Analysis', JOURNAL OF MEDICAL INTERNET RESEARCH, 21 (2019) [C1]
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Nova |
2019 |
Revelas M, Thalamuthu A, Oldmeadow C, Evans T-J, Armstrong NJ, Riveros C, et al., 'Exceptional Longevity and Polygenic Risk for Cardiovascular Health', GENES, 10 (2019) [C1]
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Nova |
2019 |
Enjeti AK, Ariyarajah A, D'Crus A, Riveros C, Seldon M, Lincz LF, 'Circulating microvesicles are less procoagulant and carry different miRNA cargo in myelodysplasia', BLOOD CELLS MOLECULES AND DISEASES, 74 37-43 (2019) [C1]
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Nova |
2019 |
Hendrickx W, Riveros C, Askim T, Bussmann JBJ, Callisaya ML, Chastin SFM, et al., 'Identifying factors associated with sedentary time after stroke. Secondary analysis of pooled data from nine primary studies.', Topics in Stroke Rehabilitation, 26 327-334 (2019) [C1]
Background: High levels of sedentary time increases the risk of cardiovascular disease, including recurrent stroke. Objective: This study aimed to identify factors associated with... [more]
Background: High levels of sedentary time increases the risk of cardiovascular disease, including recurrent stroke. Objective: This study aimed to identify factors associated with high sedentary time in community-dwelling people with stroke. Methods: For this data pooling study, authors of published and ongoing trials that collected sedentary time data, using the activPAL monitor, in community-dwelling people with stroke were invited to contribute their raw data. The data was reprocessed, algorithms were created to identify sleep-wake time and determine the percentage of waking hours spent sedentary. We explored demographic and stroke-related factors associated with total sedentary time and time in uninterrupted sedentary bouts using unique, both univariable and multivariable, regression analyses. Results: The 274 included participants were from Australia, Canada, and the United Kingdom, and spent, on average, 69% (SD 12.4) of their waking hours sedentary. Of the demographic and stroke-related factors, slower walking speeds were significantly and independently associated with a higher percentage of waking hours spent sedentary (p = 0.001) and uninterrupted sedentary bouts of >30 and >60 min (p = 0.001 and p = 0.004, respectively). Regression models explained 11¿19% of the variance in total sedentary time and time in prolonged sedentary bouts. Conclusion: We found that variability in sedentary time of people with stroke was largely unaccounted for by demographic and stroke-related variables. Behavioral and environmental factors are likely to play an important role in sedentary behavior after stroke. Further work is required to develop and test effective interventions to address sedentary behavior after stroke.
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Nova |
2019 |
Hyde LL, Boyes AW, Mackenzie LJ, Leigh L, Oldmeadow C, Riveros C, Sanson-Fisher R, 'Electronic Health Literacy Among Magnetic Resonance Imaging and Computed Tomography Medical Imaging Outpatients: Cluster Analysis (Preprint)', Journal of Medical Internet Research, 21 (2019)
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2017 |
Dudding-Byth T, Baxter A, Holliday EG, Hackett A, O'Donnell S, White SM, et al., 'Computer face-matching technology using two-dimensional photographs accurately matches the facial gestalt of unrelated individuals with the same syndromic form of intellectual disability', BMC Biotechnology, 17 (2017) [C1]
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Nova |
2017 |
Milioli HH, Tishchenko I, Riveros C, Berretta R, Moscato P, 'Basal-like breast cancer: molecular profiles, clinical features and survival outcomes', BMC MEDICAL GENOMICS, 10 (2017) [C1]
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Nova |
2016 |
Tishchenko I, Riveros C, Moscato P, 'Alzheimer s disease patient groups derived from a multivariate analysis of cognitive test outcomes in the Coalition Against Major Diseases dataset', Future Science OA, 2 FSO140-FSO140 (2016) [C1]
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Nova |
2016 |
Tishchenko I, Milioli HH, Riveros C, Moscato P, 'Extensive Transcriptomic and Genomic Analysis Provides New Insights about Luminal Breast Cancers', PLOS ONE, 11 (2016) [C1]
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Nova |
2016 |
Casanova R, Varma S, Simpson B, Kim M, An Y, Saldana S, et al., 'Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals', ALZHEIMERS & DEMENTIA, 12 815-822 (2016) [C1]
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Nova |
2016 |
Puthiyedth N, Riveros C, Berretta R, Moscato P, 'Identification of Differentially Expressed Genes through Integrated Study of Alzheimer's Disease Affected Brain Regions', PLOS ONE, 11 (2016) [C1]
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Nova |
2016 |
Riveros C, Ujaldón M, Moscato P, 'GPU Acceleration of an Entropy-based Model to Quantify Epistatic Interactions Between SNPs', Current Bioinformatics, 11 396-407 (2016) [C1]
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Nova |
2016 |
Milioli HH, Vimieiro R, Tishchenko I, Riveros C, Berretta R, Moscato P, 'Iteratively refining breast cancer intrinsic subtypes in the METABRIC dataset.', BioData Min, 9 2 (2016) [C1]
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Nova |
2015 |
Puthiyedth N, Riveros C, Berretta R, Moscato P, 'A New Combinatorial Optimization Approach for Integrated Feature Selection Using Different Datasets: A Prostate Cancer Transcriptomic Study.', PLoS One, 10 e0127702 (2015) [C1]
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Nova |
2015 |
Milioli HH, Vimieiro R, Riveros C, Tishchenko I, Berretta R, Moscato P, 'The Discovery of Novel Biomarkers Improves Breast Cancer Intrinsic Subtype Prediction and Reconciles the Labels in the METABRIC Data Set.', PLoS One, 10 e0129711 (2015) [C1]
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Nova |
2014 |
Arefin AS, Vimieiro R, Riveros C, Craig H, Moscato P, 'An information theoretic clustering approach for unveiling authorship affinities in Shakespearean era plays and poems.', PloS one, 9 e111445 (2014) [C1]
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Nova |
2014 |
Milward EA, Moscato P, Riveros C, Johnstone DM, 'Beyond Statistics: A New Combinatorial Approach to Identifying Biomarker Panels for the Early Detection and Diagnosis of Alzheimer's Disease', JOURNAL OF ALZHEIMERS DISEASE, 39 211-217 (2014) [C1]
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Nova |
2014 |
Mate K, Riveros C, Weidenhofer J, Goldie B, Scott J, Moscato P, et al., 'Strategies for Enhancing Communication between Students, Academics and Researchers participating in Large-Scale Undergraduate Research Projects', International Journal of Innovation in Science and Mathematics Education, 22 14-29 (2014) [C1]
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Nova |
2013 |
Mendes A, Boland N, Guiney P, Riveros C, 'Switch and Tap-Changer Reconfiguration of Distribution Networks Using Evolutionary Algorithms', IEEE TRANSACTIONS ON POWER SYSTEMS, 28 85-92 (2013) [C1]
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Nova |
2013 |
Johnstone DM, Riveros C, Heidari M, Graham RM, Trinder D, Berretta R, et al., 'Evaluation of Different Normalization and Analysis Procedures for Illumina Gene Expression Microarray Data Involving Small Changes', Microarrays, 2 131-152 (2013) [C1]
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Nova |
2012 |
Johnstone DM, Graham RM, Trinder D, Delima RD, Riveros RC, Olynyk JK, et al., 'Brain transcriptome perturbations in the Hfe(-/-) mouse model of genetic iron loading', Brain Research, 1448 144-152 (2012) [C1]
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Nova |
2012 |
Ravetti MG, Riveros RC, Mendes ADS, Resende MGC, Pardalos PM, 'Parallel hybrid heuristics for the permutation flow shop problem', Annals of Operations Research, 199 269-284 (2012) [C1]
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Nova |
2012 |
Johnstone DM, Graham RM, Trinder D, Riveros RC, Olynyk JK, Scott R, et al., 'Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk', Journal of Alzheimers Disease, 30 791-803 (2012) [C1]
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Nova |
2012 |
Arefin AS, Riveros RC, Berretta RE, Moscato PA, 'GPU-FS-kNN: A software tool for fast and scalable kNN computation using GPUs', PLOS One, 7 (2012) [C1]
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Nova |
2011 |
Oldmeadow CJ, Riveros RC, Holliday EG, Scott R, Moscato PA, Wang JJ, et al., 'Sifting the wheat from the chaff: Prioritizing GWAS results by identifying consistency across analytical methods', Genetic Epidemiology, 35 745-754 (2011) [C1]
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Nova |
2010 |
Riveros RC, Mellor D, Gandhi KS, McKay FC, Cox MB, Berretta RE, et al., 'A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis', Plos One, 5 1-28 (2010) [C1]
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Nova |
2010 |
Gandhi KS, McKay FC, Cox MB, Riveros RC, Armstrong N, Heard RN, et al., 'The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis', Human Molecular Genetics, 19 2134-2143 (2010) [C1]
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Nova |
2009 |
Ikin A, Riveros RC, Moscato PA, Mendes ADS, 'The Gene Interaction Miner: A new tool for data mining contextual information for protein-protein interaction analysis', Bioinformatics, 26 283-284 (2009) [C1]
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Nova |
1989 |
Riveros C, Logiudice EA, Vucetich H, 'On differential fifth force measurements', Physics Letters A, 136 343-347 (1989)
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1988 |
Horvath JE, Logiudice EA, Riveros C, Vucetich H, 'Einstein equivalence principle and theories of gravitation: A gravitationally modified standard model', Physical Review D, 38 (1988)
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1986 |
Riveros C, Vucetich H, 'Bounds on the validity of Newton's gravitational law from electromagnetic solar deflection', Physical Review D, 34 (1986)
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