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Associate Professor Jodie Simpson

Associate Professor

School of Biomedical Sciences and Pharmacy

A breath of fresh air

Dr Jodie Simpson's pioneering research has changed the focus of asthma treatment and promises new relief for many who suffer from the disease.

Jodie Simpson near some trees 

Making the transition from pure science to medical research involved a leap of faith for Dr Jodie Simpson, but the accomplished asthma researcher has not looked back since joining the University of Newcastle's leading respiratory group. The chemistry graduate's science background prompted her to approach research questions with a different perspective and subsequently led to a breakthrough finding about asthma subtypes that has brought her international recognition in the field.

Simpson was appointed as a research assistant with the respiratory team, based at the Hunter Medical Research Institute (HMRI), in 1997 after completing her Honours in chemistry. When she began studying asthma, the accepted treatment paradigm was using steroid-based medications to target inflammation in the airways caused by increased levels of eosinophils (a type of white blood cell). However, Simpson was puzzled by the fact that some asthma sufferers had normal levels of eosinophils, which led her to question whether there could be more than one type of the disease. 

"I could never understand why it was assumed that all asthma was due to increased eosinophils when only about half of the patient studies we saw had that characterisation," Simpson reflects.

Encouraged by a small numberof scholarly reports advocating a similar theory, Simpson embarked in 2002 on an ambitious PhD project investigating the inflammatory pathways of asthma, counting cells in sputum samples and analysing levels of enzymes and proteins. Simpson concluded that there were four subtypes of asthma and, significantly, identified a non-eosinophilic category common among people who did not respond well to conventional, steroid-based treatments. This subtype is characterised by higher levels of a different white blood cell, called the neutrophil.

Simpson's research led to a randomised control trial, conducted in Newcastle, which produced another breakthrough finding, published in 2008 in the American Journal of Critical and Respiratory Care Medicine. The study established that treating people who suffered from non-eosinophilic asthma with macrolide antibiotics successfully reduced their neutrophil levels and resulted in a clinical improvement in their condition. "It was a small study, but novel at the time, and it showed that identifying the inflammatory phenotype was important for the effective management of asthma," Simpson explains.

That original eight-week, 45-person study has since evolved into a four-year, 420-person national trial led by Professor Peter Gibson, with whom Simpson has worked closely, and funded by the National Health and Medical Research Council. The $2.9 million AMAZES trial (Asthma and Macrolides: the Azithromycin Efficacy and Safety Study) seeks to determine whether treating asthmatics with macrolides in addition to their normal medication can reduce the incidence of severe attacks, known as exacerbations, and ease their general symptoms.

"The focus of the AMAZES study is treatment but it has all developed from the original idea of characterising subtypes of asthma," Simpson comments. "Instead of a blanket treatment for everyone who has asthma, we can now move towards a more individualised approach, drawing from a range of effective treatments."

As well as working on the AMAZES trial, Simpson has instigated a series of peripheral studies aimed at increasing understanding of non-eosinophilic asthma. One project is testing the extent to which sufferers can reduce their steroid medication without a detrimental impact on their health; another is testing alternatives to macrolide antibiotics for reducing inflammation; and a third is investigating possible triggers for the condition, such as reflux and cough. She is also working with colleague Dr Katie Baines to advance the characterisation of asthma subtypes through gene expression.

"Substantial progress has been made in understanding non-eosinophilic asthma but there is far more that we need to know," Simpson acknowledges.  "We want to attack it from all angles."

Off to a flying start

How does a chemistry graduate come to supervise a medical trial for her first postdoctoral project? For Dr Jodie Simpson, the encouragement of her supervisor and mentor Professor Peter Gibson was critical to her rapid and successful induction to the field of asthma research. Gibson is co-director of the HMRI Viruses, Infections/Immunity, Vaccines and Asthma (VIVA) Program and has been an influential figure in Simpson's career.

"What he did from the beginning was provide opportunity," Simpson asserts. "I came to the team with an Honours degree in chemistry and he gave me the chance to learn about the clinical side of research and participate in it. To be able to lead a clinical trial for my first project after my PhD was such a wonderful opportunity."

The insight into clinical issues that Simpson gained from working with Gibson has greatly enhanced her work. "When you are in the lab counting cells and measuring proteins, you can lose the sight of the fact that this is all about a person out there who is struggling to breathe and function," she advises. "Working in this team, where we can combine basic science and clinical work, has given me a more rounded perspective."

The mother of two toddlers acknowledges that the supportive environment at the University and HMRI for researchers with young families has been critical to her work. "As researchers we are passionate about what we do and it is important to have the support to remain productive during periods where we might have to modify our working commitments."

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Jodie Simpson with her daughter near a wattle tree

A breath of fresh air

Dr Jodie Simpson’s pioneering research has changed the focus of asthma treatment and promises new relief for many who suffer from the disease.

Read more

Career Summary

Biography

Jodie Simpson is a senior research fellow in The University of Newcastle’s Priority Research Centre for Asthma and Respiratory Disease and the current holder of the Australian Respiratory Council’s Ann Woolcock Research Fellowship.

Her research focuses on the inflammatory biomarkers of airways disease and she has a particular interest in innate immune pathways and their role in airways disease. She has developed several important assays for the assessment of inflammatory mediators in airway secretions and continues to work on assessment of novel markers of airway inflammation.

In 2005, Jodie completed her PhD where she identified and characterised four inflammatory phenotypes in asthma based on the presence of absence of increased sputum eosinophil and neutrophil proportions. This work has led to further investigations of asthma inflammatory phenotypes using gene expression profiling and recently the identification of novel biomarkers for asthma and COPD.

Dr Simpson designed and conducted the first RCT of macrolide antibiotics in severe refractory asthma, this research was pivotal in her success with a large NHMRC project grant awarded in 2008 to investigate macrolide antibiotic therapy in asthma as a multi-centre RCT (The AMAZES study).

In her earlier work, Dr Simpson demonstrated that macrolide antibiotics are an effective anti-inflammatory therapy in non-eosinophilic refractory asthma. She is currently working on the AMAZES study collaborating with centres around Australia and working on 2 sub-studies, the first looking at macrophage phagocytosis and the second investigating airway and systemic inflammation in asthma subtypes.

Jodie has actively presented her work at national and international scientific meetings and has authored over 50 papers in peer reviewed journals. She is an active participant in research service and teaching as representative on TSANZ research subcommittee and the supervisor of 4 research higher degree students.

Research Expertise
Jodie Simpson is a senior research fellow in The University of Newcastle’s Priority Research Centre for Asthma and Respiratory Disease and the current holder of the Australian Respiratory Council’s Ann Woolcock Research Fellowship. Her research focuses on the inflammatory biomarkers of airways disease and she has a particular interest in innate immune pathways and their role in airways disease


Qualifications

  • PhD (Medicine), University of Newcastle
  • Bachelor of Science, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle

Keywords

  • COPD
  • asthma
  • asthma and COPD
  • clinical trials
  • immune response
  • induced sputum
  • inflammation
  • inflammatory mediators

Fields of Research

Code Description Percentage
110203 Respiratory Diseases 100

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2010 - 1/07/2014 Fellow University of Newcastle
School of Medicine and Public Health
Australia

Membership

Dates Title Organisation / Department
Member - Thoracic Society of Australia and New Zealand The Thoracic Society of Australia and New Zealand
Australia
Member - American Thoracic Society American Thoracic Society
United States

Professional appointment

Dates Title Organisation / Department
1/11/1997 - 1/08/2005 Scientific Officer Hunter Area Health Service
Respiratory and Sleep Medicine
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2009 Simpson JL, Baines KJ, Gibson PG, 'Biology of neutrophils', Middleton's Allergy: Principles & Practice, Mosby, Philadelphia, Pennsylvania 283-294 (2009) [B1]
Co-authors Peter Gibson, Katherine Baines

Journal article (81 outputs)

Year Citation Altmetrics Link
2015 Upham J, Chen A, Carroll M, Petsky H, Pizzutto S, Yerkovich S, et al., 'IMMUNE RESPONSES TO NONTYPEABLE HAEMOPHILUS INFLUENZAE IN PROTRACTED BACTERIAL BRONCHITIS', RESPIROLOGY, 20 34-34 (2015)
2015 Baines K, Wright T, Simpson J, Mcdonald V, Wood L, Gibson P, 'EXCESSIVE NEUTROPHIL EXTRACELLULAR TRAPS ARE ASSOCIATED WITH INFLAMMATION IN CHRONIC AIRWAY DISEASE', RESPIROLOGY, 20 45-45 (2015)
2015 Simpson J, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, et al., 'SPUTUM AND SERUM PERIOSTIN LEVELS ARE ASSOCIATED WITH, BUT DO NOT PREDICT SPUTUM EOSINOPHIL PROPORTION IN SEVERE ASTHMA', RESPIROLOGY, 20 68-68 (2015)
Co-authors Peter Gibson
2015 Erriah M, Gao P, Baines K, Gibson P, Simpson J, 'SPUTUM GALECTIN-3 EXPRESSION IS ASSOCIATED WITH EOSINOPHILS IN COPD', RESPIROLOGY, 20 80-80 (2015)
2015 Essilfie A-T, Horvat JC, Kim RY, Mayall JR, Pinkerton JW, Beckett EL, et al., 'Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma', THORAX, 70 458-U151 (2015)
DOI 10.1136/thoraxjnl-2014-206067
Citations Web of Science - 1
Co-authors Paul Foster, Peter Gibson, Philip Hansbro, Malcolm Starkey, Jay Horvat
2015 Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, et al., 'Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1 beta', RESPIRATORY RESEARCH, 16 (2015)
DOI 10.1189/s12931-014-0163-5
Co-authors Katherine Baines, Peter Gibson
2014 Baines KJ, Upham JW, Yerkovich ST, Chang AB, Marchant JM, Carroll M, et al., 'Mediators of neutrophil function in children with protracted bacterial bronchitis', Chest, 146 1013-1020 (2014) [C1]
DOI 10.1378/chest.14-0131
Citations Scopus - 2Web of Science - 2
Co-authors Peter Gibson, Katherine Baines
2014 Fu J-J, Gibson PG, Simpson JL, McDonald VM, 'Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome', Respiration, 87 63-74 (2014) [C1]

Background: The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults i... [more]

Background: The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults is not well understood. Objective: To examine the prognosis of OADs and to identify potential determinants for longitudinal changes in clinical outcomes. Methods: We consecutively recruited 99 older adults (>55 years) with OADs who underwent a multidimensional assessment at baseline and 4 years which involved spirometry, 6-min walk distance (6MWD), assessments of health status (Saint George's Respiratory Questionnaire, SGRQ), comorbidity, and serum and sputum biomarkers. All-cause mortality and respiratory hospitalisation during the follow-up period were recorded. Clinical outcomes were compared between basal and final visits, and changes in clinical outcomes were compared among asthma, COPD and asthma-COPD overlap groups. Associations between clinical parameters, biomarkers and prognosis were examined. Results: After a median follow-up of 4.2 years, outcome data were available for 75 (75.8%) patients. There were 16 (16.2%) deaths. The BODE index predicted all-cause mortality in older people with OADs. While spirometry, 6MWD and SGRQ deteriorated significantly over the 4 years, there was significant heterogeneity in the longitudinal changes in these clinical outcomes. Participants with COPD had a significant decline in FEV1 (p = 0.003), SGRQ (p = 0.030) and 6MWD [decline of 75.5 (93.4) m, p = 0.024]. The change in 6MWD was lower in the asthma-COPD overlap group. Airflow reversibility was associated with a reduced decline in 6MWD. Conclusion: COPD patients had a poor prognosis compared with asthma and asthma-COPD overlap patients. The BODE index is a useful prognostic indicator in older adults with OADs. Both airway disease diagnosis and BODE index warrant specific attention in clinical practice. © 2013 S. Karger AG, Basel.

DOI 10.1159/000352053
Citations Scopus - 12Web of Science - 10
Co-authors Peter Gibson, Vanessa Mcdonald
2014 Simpson JL, Baines KJ, Ryan N, Gibson PG, 'Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD', Asian Pacific Journal of Allergy and Immunology, 32 66-74 (2014) [C1]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma... [more]

Background: Asthma is a heterogeneous inflammatory disease and eosinophilic, noneosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms and inflammation. Objective: This study sought to characterise asthma control, exacerbation frequency and potential triggers of non-eosinophilic and specifically neutrophilic asthma such as infection, gastroesophageal reflux disease, and rhinosinusitis. Methods: Adults with asthma (n=65; doctor's diagnosis plus demonstrated response to bronchodilator and/or airways hyperresponsiveness to hypertonic saline) were recruited from the Respiratory and Sleep Medicine Ambulatory Care Service at John Hunter Hospital, NSW, Australia. Questionnaires were administered to assess gastroesophageal reflux disease, rhinosinusitis and asthma control. A sputum induction was performed and sputum was processed for assessment of inflammatory cells, infection, and lipid laden macrophages (Oil Red O). Results: Participants with neutrophilic asthma (n=11, 23%) had a higher frequency of primary care doctor visits for asthma exacerbations and a high prevalence (>70%) of chest infections in the previous 12 months. There was also an increased prevalence of rhinosinusitis (64%) and increased symptoms of gastroesophageal reflux disease compared to those with eosinophilic asthma. Conclusions: The clinical pattern of neutrophilic asthma is different from paucigranulocytic and eosinophilic asthma with evidence of abnormal upper airways responses. Specific and targeted treatment of these airway problems may assist in the control and management of neutrophilic asthma.

DOI 10.12932/AP0322.32.1.2014
Citations Scopus - 1
Co-authors Katherine Baines, Peter Gibson, Nicole Ryan
2014 Simpson JL, Phipps S, Baines KJ, Oreo KM, Gunawardhana L, Gibson PG, 'Elevated expression of the NLRP3 inflammasome in neutrophilic asthma', European Respiratory Journal, 43 1067-1076 (2014) [C1]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generatio... [more]

Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1ß is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of active IL-1ß requires proteolytic cleavage typically mediated through the formation of a caspase-1-containing inflammasome. This study hypothesised that an IL-1ß endotype associated with the nucleotide-binding domain, leucine-rich repeat-containing family protein (NLRP)3/apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)/caspase-1 inflammasome is characteristic of patients with the neutrophilic subtype of asthma. Participants with asthma (n=85) and healthy controls (n=27) underwent clinical assessment, spirometry and sputum induction. Sputum was processed for differential cell count, gene expression and protein mediators. NLRP3 and caspase-1 expression was also determined by immunocytochemistry. Sputum macrophages were isolated (n=8) and gene expression of NLRP3 and IL-1ß determined. There was significantly elevated gene expression of NLRP3, caspase-1, caspase-4, caspase-5 and IL-1ß in participants with neutrophilic asthma. Protein levels of IL-1ß were significantly higher in those with neutrophilic asthma and correlated with sputum IL-8 levels. Sputum macrophages, as well as sputum neutrophils in neutrophilic asthma, expressed NLRP3 and caspase-1 protein. NLRP3 inflammasome is upregulated in neutrophilic asthma and may regulate the inflammation process observed in this asthma phenotype through production of IL-1ß. Copyright © ERS 2014.

DOI 10.1183/09031936.00105013
Citations Scopus - 9Web of Science - 9
Co-authors Peter Gibson, Katherine Baines
2014 Oreo KM, Gibson PG, Simpson JL, Wood LG, Mcdonald VM, Baines KJ, 'Sputum ADAM8 expression is increased in severe asthma and COPD', Clinical and Experimental Allergy, 44 342-352 (2014) [C1]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin... [more]

Background: Severe asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory airway diseases in which the mechanisms are not fully understood. A disintegrin and metalloproteinase domain 8 (ADAM8) is an enzyme expressed on most leucocytes and may be important for facilitating leucocyte migration in respiratory disease. Objective: To investigate ADAM8 mRNA and protein expression in asthma and COPD and its relationship between asthma severity and inflammatory phenotypes. Methods: Induced sputum was collected from 113 subjects with asthma (severe n = 31, uncontrolled n = 39 and controlled n = 35), 20 subjects with COPD and 21 healthy controls. Sputum ADAM8 mRNA expression was measured by qPCR, and soluble ADAM8 (sADAM8) protein was measured in the sputum supernatant by validated ELISA. Results: ADAM8 mRNA correlated with ADAM8 protein levels (r = 0.27, P < 0.01). ADAM8 mRNA (P = 0.004) and sADAM8 protein (P = 0.014) levels were significantly higher in both asthma and COPD compared with healthy controls. ADAM8 mRNA (P = 0.035) and sADAM8 protein (P = 0.002) levels were significantly higher in severe asthma compared with controlled asthma. Total inflammatory cell count (P < 0.01) and neutrophils (P < 0.01) were also elevated in severe asthmatic sputum. Although ADAM8 mRNA was significantly higher in eosinophilic and neutrophilic asthma (P < 0.001), sADAM8 did not differ between asthma inflammatory phenotypes. ADAM8 expression positively correlated with sputum total cell count and sputum neutrophils. Conclusions and Clinical Relevance: ADAM8 expression is increased in both severe asthma and COPD and associated with sputum total cell count and neutrophils. ADAM8 may facilitate neutrophil migration to the airways in severe asthma and COPD. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/cea.12223
Citations Scopus - 1Web of Science - 1
Co-authors Vanessa Mcdonald, Katherine Baines, Peter Gibson, Lisa Wood
2014 Zhang X-Y, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, et al., 'Full blood count parameters for the detection of asthma inflammatory phenotypes', Clinical and Experimental Allergy, 44 1137-1145 (2014) [C1]

Summary: Background: In asthma, the airway inflammatory phenotype influences clinical characteristics and treatment response. Although induced sputum is the gold standard test for... [more]

Summary: Background: In asthma, the airway inflammatory phenotype influences clinical characteristics and treatment response. Although induced sputum is the gold standard test for phenotyping asthma, a more accessible method is needed for clinical practice. Objective: To investigate whether white blood cell counts and/or their derived ratios can predict sputum eosinophils or neutrophils in uncontrolled asthma. Methods: This cross-sectional study evaluated 164 treated but uncontrolled asthmatic patients with sputum induction and blood collection. Receiver-operating characteristic (ROC) curves were used to assess the relationship between blood and sputum parameters. Results: There was a significant positive relationship between blood eosinophil parameters and the percentage of sputum eosinophil count. A weak but significant correlation was found between sputum neutrophil percentage and blood neutrophil percentage (r = 0.219, P = 0.005). ROC curve analysis identified that blood eosinophil percentage count was the best predictor for eosinophilic asthma, with an area under the curve (AUC) of 0.907 (P < 0.001). The optimum cut-point for blood eosinophil percentage was 2.7%, and this yielded a sensitivity of 92.2% and a specificity of 75.8%. The absolute blood eosinophil count was also highly predictive with an AUC of 0.898 (P < 0.0001) at a blood eosinophil cut-off of 0.26 × 109/L. The blood eosinophil/lymphocyte ratio (ELR) and eosinophil/neutrophil ratio (ENR) were increased in eosinophilic asthma, and the neutrophil/lymphocyte ratio (NLR) was increased in neutrophilic asthma. Neutrophilic asthma could also be detected by blood neutrophil percentages and NLR, but with less accuracy. Conclusions and Clinical Relevance: Blood eosinophil counts and derived ratios (ELR and ENR) can accurately predict eosinophilic asthma in patients with persistent uncontrolled asthma despite treatment. Blood neutrophil parameters are poor surrogates for the proportion of sputum neutrophils. Blood counts may be a useful aid in the monitoring of uncontrolled asthma. © 2014 John Wiley & Sons Ltd.

DOI 10.1111/cea.12345
Citations Scopus - 5Web of Science - 6
Co-authors Peter Gibson
2014 Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, Hodge S, 'Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma', RESPIROLOGY, 19 280-287 (2014) [C1]
DOI 10.1111/resp.12213
Citations Scopus - 1Web of Science - 1
Co-authors Peter Gibson
2014 Gunawardhana LP, Gibson PG, Simpson JL, Powell H, Baines KJ, 'Activity and expression of histone acetylases and deacetylases in inflammatory phenotypes of asthma', Clinical & Experimental Allergy, 44 47-57 (2014) [C1]
DOI 10.1111/cea.12168
Citations Scopus - 3Web of Science - 2
Co-authors Peter Gibson, Katherine Baines
2014 Gibson PG, Simpson JL, Ryan NM, Vertigan AE, 'Mechanisms of cough', CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 14 55-61 (2014) [C1]
DOI 10.1097/ACI.0000000000000027
Citations Scopus - 3Web of Science - 3
Co-authors Nicole Ryan, Peter Gibson
2014 Simpson JL, Powell H, Baines KJ, Milne D, Coxson HO, Hansbro PM, Gibson PG, 'The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial', PLOS ONE, 9 (2014) [C1]
DOI 10.1371/journal.pone.0105609
Citations Scopus - 3Web of Science - 2
Co-authors Peter Gibson, Katherine Baines, Philip Hansbro
2014 Baines KJ, Simpson JL, Wood LG, Scott RJ, Fibbens NL, Powell H, et al., 'Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes', Journal of Allergy and Clinical Immunology, 133 997-1007 (2014) [C1]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputu... [more]

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes. Methods An asthma phenotype biomarker discovery study generated gene expression profiles from induced sputum of 47 asthmatic patients. A clinical validation study (n = 59 asthmatic patients) confirmed differential expression of key genes. A 6-gene signature was identified and evaluated for reproducibility (n = 30 asthmatic patients and n = 20 control subjects) and prediction of inhaled corticosteroid (ICS) response (n = 71 asthmatic patients). Receiver operating characteristic curves were calculated, and area under the curve (AUC) values were reported. Results From 277 differentially expressed genes between asthma inflammatory phenotypes, we identified 23 genes that showed highly significant differential expression in both the discovery and validation populations. A signature of 6 genes, including Charcot-Leydon crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1ß (IL1B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (CXCR2), was reproducible and could significantly (P <.0001) discriminate eosinophilic asthma from other phenotypes, including patients with noneosinophilic asthma (AUC, 89.6%), paucigranulocytic asthma (AUC, 92.6%), or neutrophilic asthma (AUC, 91.4%) and healthy control subjects (AUC, 97.6%), as well as discriminating patients with neutrophilic asthma from those with paucigranulocytic asthma (AUC, 85.7%) and healthy control subjects (AUC, 90.8). The 6-gene signature predicted ICS response (>12% change in FEV1; AUC, 91.5%). ICS treatment reduced the expression of CLC, CPA3, and DNASE1L3 in patients with eosinophilic asthma. Conclusions A sputum gene expression signature of 6 biomarkers reproducibly and significantly discriminates inflammatory phenotypes of asthma and predicts ICS treatment response. This signature has the potential to become a useful diagnostic tool to assist in the clinical diagnosis and management of asthma. © 2013 American Academy of Allergy, Asthma & Immunology.

DOI 10.1016/j.jaci.2013.12.1091
Citations Scopus - 11Web of Science - 13
Co-authors Lisa Wood, Peter Gibson, Rodney Scott, Katherine Baines
2014 Fu J-J, McDonald VM, Gibson PG, Simpson JL, 'Systemic inflammation in older adults with asthma-COPD overlap syndrome', Allergy, Asthma and Immunology Research, 6 316-324 (2014) [C1]

Purpose: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to id... [more]

Purpose: The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. Methods: In 108 adults older than 55 years comprising healthy controls (n=29), asthma (n=16), COPD (n=21) and asthma-COPD overlap syndrome (n=42), serum high sensitivity C-reactive protein and Interleukin 6 (IL-6) were assayed. Spirometry, induced sputum, quality of life, comorbidities and medications were assessed, and their associations with asthma-COPD overlap syndrome were analyzed using logistic regression. Associations between systemic inflammatory mediators and clinical characteristics were tested in multivariate linear regression models. Results: Patients with asthma-COPD overlap syndrome had significantly elevated IL-6 levels compared with healthy controls and asthmatics. Age, comorbidity index and IL-6 level were independently associated with asthma-COPD overlap syndrome. FEV1% predicted was inversely associated with IL-6 level, and cardiovascular disease was associated with an increased IL-6 level. Systemic markers were not associated with airway inflammation. Conclusions: Systemic inflammation is commonly present in asthma-COPD overlap syndrome, and asthma-COPD overlap syndrome resembled COPD in terms of systemic inflammation. IL-6 is a pivotal inflammatory mediator that may be involved in airflow obstruction and cardiovascular disease and may be an independent treatment target. © Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology.

DOI 10.4168/aair.2014.6.4.316
Citations Scopus - 6Web of Science - 6
Co-authors Vanessa Mcdonald, Peter Gibson
2014 Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy', Pediatric Pulmonology, 49 852-862 (2014) [C1]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important... [more]

Background Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic alterations that predispose infants to a greater risk of developing asthma themselves. We investigated alterations in the DNA methylation profile of peripheral blood from infants exposed to maternal asthma during pregnancy. Methods Peripheral blood was collected from 12-month-old infants born to women with (n = 25) and without (n = 15) doctor diagnosed asthma during pregnancy. Genomic DNA was extracted, bisulfite converted, and hybridized to Infinium Methylation 27 arrays (Illumina), containing over27,000 CpGs from 14,495 genes. CpG loci in only autosomal genes were classified as differentially methylated at the 99% level (P < 0.01, |DiffScore| > 22 and delta beta >0.06). Results There were 70 CpG loci, corresponding to 67 genes that were significantly differentially methylated. Twelve CpG loci (11 genes) showed greater than 10% comparative difference in DNA methylation, including hyper-methylated loci of FAM181A, MRI1, PIWIL1, CHFR, DEFA1, MRPL28, AURKA, and hypo-methylated loci of NALP1L5, MAP8KIP3, ACAT2, and PM20D1 in maternal asthma. Methylation of MAPK8IP3 was significantly negatively correlated with maternal blood eosinophils (r = -0.38; P = 0.022), maternal eNO (r = -0.44; P = 0.005), and maternal serum total IgE (r = -0.39, P = 0.015). Methylation of AURKA negatively correlated with maternal hemoglobin (r = -0.43; P = 0.008), infants height (r = -0.51; P < 0.001) and weight (r = -0.36; P = 0.021). Methylation of PM20D1 was lower in infants born to mothers with asthma on inhaled corticosteroid treatment. Methylation of PM20D1 was lower and MRI1 was higher in infants born to atopic mothers without asthma. Conclusions In an Australian study population, exposure to maternal asthma during pregnancy is associated with differential methylation profiles of infants' peripheral blood DNA, which may act as risk factors for future asthma development. © 2013 Wiley Periodicals, Inc.

DOI 10.1002/ppul.22930
Citations Scopus - 3Web of Science - 2
Co-authors Peter Gibson, Vanessa Murphy, Joerg Mattes, Katherine Baines
2014 Simpson JL, Guest M, Boggess MM, Gibson PG, 'Occupational exposures, smoking and airway inflammation in refractory asthma', BMC PULMONARY MEDICINE, 14 (2014) [C1]
DOI 10.1186/1471-2466-14-207
Co-authors Peter Gibson
2014 Gunawardhana LP, Gibson PG, Simpson JL, Benton MC, Lea RA, Baines KJ, 'Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.', Epigenetics, 9 1302-1316 (2014) [C1]
DOI 10.4161/epi.33066
Citations Scopus - 2Web of Science - 3
Co-authors Katherine Baines, Peter Gibson
2013 Kaiko GE, Loh Z, Spann K, Lynch JP, Lalwani A, Zheng Z, et al., 'Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131 1331-U132 (2013) [C1]
DOI 10.1016/j.jaci.2013.02.041
Citations Scopus - 20Web of Science - 18
Co-authors Katherine Baines, Paul Foster
2013 Simpson JL, Gibson PG, Yang IA, Upham J, James A, Reynolds PN, Hodge S, 'Impaired macrophage phagocytosis in non-eosinophilic asthma', CLINICAL AND EXPERIMENTAL ALLERGY, 43 29-35 (2013) [C1]
DOI 10.1111/j.1365-2222.2012.04075.x
Citations Scopus - 20Web of Science - 18
Co-authors Peter Gibson
2013 Simpson JL, McDonald VM, Baines KJ, Oreo KM, Wang F, Hansbro PM, Gibson PG, 'Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD', MEDIATORS OF INFLAMMATION, (2013) [C1]
DOI 10.1155/2013/462934
Citations Scopus - 6Web of Science - 6
Co-authors Peter Gibson, Philip Hansbro, Katherine Baines, Vanessa Mcdonald
2013 Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL, 'Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics', RESPIROLOGY, 18 857-865 (2013) [C1]
DOI 10.1111/resp.12079
Citations Scopus - 8Web of Science - 8
Co-authors Peter Gibson
2013 Gao P, Simpson JL, Zhang J, Gibson PG, 'Galectin-3: its role in asthma and potential as an anti-inflammatory target', RESPIRATORY RESEARCH, 14 (2013) [C1]
DOI 10.1186/1465-9921-14-136
Citations Scopus - 4Web of Science - 5
Co-authors Peter Gibson
2013 Mcdonald VM, Simpson JL, Mcelduff P, Gibson PG, 'Older peoples' perception of tests used in the assessment and management of COPD and asthma', Clinical Respiratory Journal, 7 367-374 (2013) [C1]

Objectives: Outcome assessment is an important part of the management of airways disease, yet older adults may have difficulty with the burden of testing. This study evaluated the... [more]

Objectives: Outcome assessment is an important part of the management of airways disease, yet older adults may have difficulty with the burden of testing. This study evaluated the patient perception of tests used for the assessment of airways disease in older people. Data Source: Older adults (>55 years) with obstructive airway disease and healthy controls (N=56) underwent inhaler technique assessment, skin allergy testing, venepuncture, fractional exhaled nitric oxide (FENO) and gas diffusion measurement, exercise testing, sputum induction, and questionnaire assessment. They then completed an assessment burden questionnaire across five domains: difficulty, discomfort, pain, symptoms and test duration. Results: Test perception was generally favourable. Induced sputum had the greatest test burden perceived as being more difficult (mean 0.83, P=0.001), associated with more discomfort (mean 1.3, P<0.001), more painful (0.46, P=0.019), longer test duration (0.84, P<0.001) and worsening symptoms (0.55, P=0.001) than the questionnaires. FENO had a more favourable assessment but was assessed to be difficult to perform. Inhaler technique received the most favourable assessment. Conclusions: Older adults hold favourable perceptions to a range of tests that they might encounter in the course of their care for airway disease. The newer tests of sputum induction and FENO have some observed difficulties, in particular sputum induction. The results of this study can inform current practice by including details of the test and its associated adverse effects when conducting the test, as well as providing clear explanations of the utility of tests and how the results might aid in patient care. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/crj.12017
Co-authors Vanessa Mcdonald, Peter Gibson
2012 Essilfie A-T, Simpson JL, Dunkley ML, Morgan LC, Oliver BG, Gibson PG, et al., 'Combined haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma', Thorax, 67 588-599 (2012) [C1]
Citations Scopus - 34Web of Science - 31
Co-authors Margaret Dunkley, Philip Hansbro, Paul Foster, Peter Gibson
2012 Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', European Respiratory Journal, 39 721-729 (2012) [C1]
Co-authors Vanessa Mcdonald, Peter Gibson, Peter Wark, Lisa Wood
2011 McDonald VM, Higgins I, Simpson JL, Gibson PG, 'The importance of clinical management problems in older people with COPD and asthma: Do patients and physicians agree?', Primary Care Respiratory Journal, 20 389-395 (2011) [C1]

Background: COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physi... [more]

Background: COPD and asthma in older people are complex conditions associated with multiple clinical problems. The relative importance of these problems to both patients and physicians and the level of agreement between them is largely unknown. Methods: Older people with asthma and COPD underwent a multidimensional assessment to characterise the prevalence of clinical problems. Each individual's problems were then summarised and presented separately to the patient and physician to rate problem importance. Problems were scored using a 5-point Likert scale from unimportant to very important. Results: The highest-rated problems were dyspnoea, activity limitation and airway inflammation, and these areas had good patientphysician concordance. Poor concordance was found for inhaler technique adequacy, airflow obstruction and obesity. Good concordance was found for written action plans, but this was less important to both patients and physicians. Conclusions: In asthma and COPD, patients and their physicians agree about the importance of managing activity limitation, dyspnoea, and airway inflammation. Other areas of management had little concordance or were viewed as less important. Self-management skills were not rated as important by patients and this may hinder successful management. Eliciting problems and addressing their importance to treatment goals may improve care in COPD and asthma. © 2011 Primary Care Respiratory Society UK. All rights reserved.

Citations Scopus - 15Web of Science - 13
Co-authors Peter Gibson, Isabel Higgins, Vanessa Mcdonald
2011 He XY, Simpson JL, Wang F, 'Inflammatory phenotypes in stable and acute childhood asthma', Paediatric Respiratory Reviews, 12 165-169 (2011) [C1]
Citations Scopus - 15Web of Science - 9
2011 Essilfie A-T, Simpson JL, Horvat JC, Preston JA, Dunkley ML, Foster PS, et al., 'Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease', PLoS Pathogens, 7 e1002244 (2011) [C1]
Co-authors Peter Gibson, Philip Hansbro, Margaret Dunkley, Paul Foster, Jay Horvat
2011 Baines KJ, Simpson JL, Gibson PG, 'Innate immune responses are increased in chronic obstructive pulmonary disease', PLoS ONE, 36 e18426 (2011) [C1]
DOI 10.1371/journal.pone.0018426
Citations Scopus - 28Web of Science - 19
Co-authors Katherine Baines, Peter Gibson
2011 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional assessment of older people with asthma and COPD: Clinical management and health status', Age and Ageing, 40 42-49 (2011) [C1]
DOI 10.1093/ageing/afq134
Citations Scopus - 19Web of Science - 18
Co-authors Vanessa Mcdonald, Isabel Higgins, Peter Gibson
2011 Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', Thorax, 66 942-947 (2011) [C1]
Citations Scopus - 15Web of Science - 16
Co-authors Rodney Scott, Lisa Wood, Peter Gibson, Katherine Baines
2011 Baines KJ, Simpson JL, Wood LG, Scott R, Gibson PG, 'Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples', Journal of Allergy and Clinical Immunology, 127 153.e9-160.e9 (2011) [C1]
DOI 10.1016/j.jaci.2010.10.024
Citations Scopus - 67Web of Science - 58
Co-authors Katherine Baines, Rodney Scott, Lisa Wood, Peter Gibson
2011 Wang F, He XY, Baines KJ, Gunawardhana LP, Simpson JL, Li F, Gibson PG, 'Different inflammatory phenotypes in adults and children with acute asthma', European Respiratory Journal, 38 567-574 (2011) [C1]
DOI 10.1183/09031936.00170110
Citations Scopus - 29Web of Science - 25
Co-authors Peter Gibson, Katherine Baines
2011 Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG, 'Characterization of innate immune signalling receptors in virus-induced acute asthma', Clinical and Experimental Allergy, 41 640-648 (2011) [C1]
DOI 10.1111/j.1365-2222.2010.03669.x
Citations Scopus - 14Web of Science - 13
Co-authors Peter Wark, Lisa Wood, Peter Gibson
2011 Verrills NM, Irwin JA, He XY, Wood LG, Powell H, Simpson JL, et al., 'Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease', American Journal of Respiratory and Critical Care Medicine, 183 1633-1643 (2011) [C1]
DOI 10.1164/rccm.201010-1623OC
Citations Scopus - 36Web of Science - 34
Co-authors Lisa Wood, Peter Gibson, Nikki Verrills, Alistair Sim, Vanessa Mcdonald
2010 Baines KJ, Simpson JL, Bowden NA, Scott R, Gibson PG, 'Differential gene expression and cytokine production from neutrophils in asthma phenotypes', European Respiratory Journal, 35 522-531 (2010) [C1]
DOI 10.1183/09031936.00027409
Citations Scopus - 32Web of Science - 24
Co-authors Nikola Bowden, Katherine Baines, Rodney Scott, Peter Gibson
2010 Wood LG, Simpson JL, Hansbro PM, Gibson PG, 'Potentially pathogenic bacteria cultured from the sputum of stable asthmatics are associated with increased 8-isoprostane and airway neutrophilia', Free Radical Research, 44 146-154 (2010) [C1]
DOI 10.3109/10715760903362576
Citations Scopus - 23Web of Science - 18
Co-authors Philip Hansbro, Peter Gibson, Lisa Wood
2009 Simpson JL, McElduff P, Gibson PG, 'Assessment and reproducibility of non-eosinophilic asthma using induced sputum', Respiration, 79 147-151 (2009) [C1]
DOI 10.1159/000245899
Citations Scopus - 29Web of Science - 28
Co-authors Peter Gibson
2009 Gibson PG, Simpson JL, 'The overlap syndrome of asthma and COPD: What are its features and how important is it?', Thorax, 64 728-735 (2009) [C1]
DOI 10.1136/thx.2008.108027
Citations Scopus - 189Web of Science - 153
Co-authors Peter Gibson
2009 Simpson JL, Phipps S, Gibson PG, 'Inflammatory mechanisms and treatment of obstructive airway diseases with neutrophilic bronchitis', Pharmacology and Therapeutics, 124 86-95 (2009) [C1]
DOI 10.1016/j.pharmthera.2009.06.004
Citations Scopus - 42Web of Science - 38
Co-authors Peter Gibson
2009 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Immune responses of airway neutrophils are impaired in asthma', Experimental Lung Research, 35 554-569 (2009) [C1]
DOI 10.1080/01902140902777490
Citations Scopus - 14Web of Science - 15
Co-authors Peter Gibson, Rodney Scott, Katherine Baines
2009 Simpson JL, Baines KJ, Boyle MJ, Scott R, Gibson PG, 'Oncostatin M (OSM) is increased in asthma with incompletely reversible airflow obstruction', Experimental Lung Research, 35 781-794 (2009) [C1]
DOI 10.3109/01902140902906412
Citations Scopus - 10Web of Science - 11
Co-authors Peter Gibson, Rodney Scott, Katherine Baines
2009 Simpson JL, Milne DG, Gibson PG, 'Neutrophilic asthma has different radiographic features to COPD and smokers', Respiratory Medicine, 103 881-887 (2009) [C1]
DOI 10.1016/j.rmed.2008.12.013
Citations Scopus - 13Web of Science - 12
Co-authors Peter Gibson
2008 Simpson JL, Powell H, Boyle MJ, Scott R, Gibson PG, 'Clarithromycin targets neutrophilic airway inflammation in refractory asthma', American Journal of Respiratory and Critical Care Medicine, 177 148-155 (2008) [C1]
DOI 10.1164/rccm.200707-1134oc
Citations Scopus - 224Web of Science - 179
Co-authors Rodney Scott, Peter Gibson
2008 Simpson JL, Brooks C, Douwes J, 'Innate immunity in asthma', Paediatric Respiratory Reviews, 9 263-270 (2008) [C1]
DOI 10.1016/j.prrv.2008.05.007
Citations Scopus - 13Web of Science - 9
2008 Simpson JL, Wark PA, 'The role of exhaled nitric oxide and exhaled breath condensates in evaluating airway inflammation in asthma', Expert Opinion on Medical Diagnostics, 2 607-620 (2008) [C1]
DOI 10.1517/17530059.2.6.607
Citations Scopus - 2
Co-authors Peter Wark
2008 Wood LG, Garg ML, Blake RJ, Simpson JL, Gibson PG, 'Oxidized vitamin E and glutathione as markers of clinical status in asthma', Clinical Nutrition, 27 579-586 (2008) [C1]
DOI 10.1016/j.clnu.2007.12.002
Citations Scopus - 17Web of Science - 14
Co-authors Lisa Wood, Peter Gibson, Manohar Garg
2007 Weckmann M, Collison A, Simpson JL, Kopp MV, Wark PA, Smyth MJ, et al., 'Critical link between TRAIL and CCL20 for the activation of T(H)2 cells and the expression of allergic airway disease', Nature Medicine, 13 1308-1315 (2007) [C1]
DOI 10.1038/nm1660
Citations Scopus - 62Web of Science - 59
Co-authors Paul Foster, Peter Gibson, Joerg Mattes, Peter Wark, Nicole Hansbro
2007 Simpson JL, Grissell TV, Douwes J, Scott R, Boyle MJ, Gibson PG, 'Innate immune activation in neutrophilic asthma and bronchiectasis', Thorax, 62 211-218 (2007) [C1]
DOI 10.1136/thx.2006.061358
Citations Scopus - 132Web of Science - 122
Co-authors Peter Gibson, Rodney Scott
2007 Yang Z, Yan WX, Cai H, Tedla N, Armishaw C, Di Girolamo N, et al., 'S100A12 provokes mast cell activation: A potential amplification pathway in asthma and innate immunity', Journal of Allergy and Clinical Immunology, 119 106-114 (2007) [C1]
DOI 10.1016/j.jaci.2006.08.021
Citations Scopus - 53Web of Science - 55
Co-authors Peter Gibson
2006 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in asthma: Assessment and identification using induced sputum', Respirology, 11 54-61 (2006) [C1]
DOI 10.1111/j.1440-1843.2006.00784.x
Citations Scopus - 246Web of Science - 226
Co-authors Rodney Scott, Peter Gibson
2005 Simpson JL, Gibson PG, 'Deficient Sputum Anti-Protease Defenses in Neutrophilic and Eosinophilic Asthma', INFLAMMATION RESEARCH, 54 S136-S137 (2005)
Co-authors Peter Gibson
2005 Bains KJ, Bell NV, Simpson JL, Scott RJ, Boyle MJ, Gibson PG, 'Enhanced IL-8 Release front Neutrophils in Non-Eosinophilic Asthma', INFLAMMATION RESEARCH, 54 S137-S137 (2005)
Co-authors Peter Gibson, Rodney Scott
2005 Simpson JL, Wood LG, Gibson PG, 'Inflammatory mediators in exhaled breath, induced sputum and saliva', Clinical & Experimental Allergy, 35 1180-1185 (2005) [C1]
DOI 10.1111/j.1365-2222.2005.02327.x
Citations Scopus - 41Web of Science - 39
Co-authors Peter Gibson, Lisa Wood
2005 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine, 172 559-565 (2005) [C1]
DOI 10.1164/rccm.200503-369OC
Citations Scopus - 94Web of Science - 86
Co-authors Peter Gibson, Rodney Scott
2005 Wood LG, Garg ML, Simpson JL, Mori TA, Croft KD, Wark PA, Gibson PG, 'Induced sputum 8-isoprostane concentrations in inflammatory airway diseases', American Journal of Respiratory and Critical Care Medicine, 171 426-430 (2005) [C1]
DOI 10.1164/rccm.200408-1010OC
Citations Scopus - 58Web of Science - 51
Co-authors Manohar Garg, Peter Gibson, Lisa Wood, Peter Wark
2004 Gibson PG, Simpson JL, Holgate ST, Dahlén S-E, Reid DW, Champion A, et al., 'The European Network For Understanding Mechanisms Of Severe Asthma study; Host response to transmissible Pseudomonas aeruginosa; The use of computer-animation programs during spirometry in preschool children', European Respiratory Journal, 23 492-495 (2004)
DOI 10.1183/09031936.04.00132904
Co-authors Peter Gibson
2004 Simpson JL, Timmins N, Fakes K, Talbot P, Gibson PG, 'Effect of saliva contamination on induced sputum cell counts, IL-8 and eosinophil cationic protein levels', European Respiratory Journal, 23 759-762 (2004) [C1]
DOI 10.1183/09031936.04.00043104a
Citations Scopus - 14Web of Science - 12
Co-authors Peter Gibson
2004 Gibson PG, Simpson JL, 'The European Network For Understanding Mechanisms Of Severe Asthma study', European Respiratory Journal, 23 492-495 (2004) [C1]
DOI 10.1183/09031936.04.00132904a
Citations Scopus - 2Web of Science - 2
Co-authors Peter Gibson
2003 Simpson JL, Moric I, Wark PA, Johnston S, Gibson PG, 'Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques', Journal of Clinical Virology, 339-346 (2003) [C1]
DOI 10.1016/S1386-6532(02)00084-7
Citations Scopus - 30Web of Science - 25
Co-authors Peter Gibson, Peter Wark
2003 Gibson PG, Simpson JL, Hankin RG, Powell HG, Henry RL, 'Relationship between included sputum eosinophils and clinical pattern of childhood asthma', Thorax, 58 116-121 (2003) [C1]
DOI 10.1136/thorax.58.2.116
Citations Scopus - 69Web of Science - 54
Co-authors Peter Gibson
2003 Wark PA, Hensley MJ, Saltos N, Boyle MJ, Toneguzzi R, Simpson JL, et al., 'Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial', The Journal of Allergy and Clinical Immunology, 111 952-957 (2003) [C1]
DOI 10.1067/mai.2003.1388
Citations Scopus - 144Web of Science - 112
Co-authors Michael Hensley, Peter Gibson, Peter Wark
2003 Gibson PG, Wark PA, Simpson JL, Meldrum CJ, Meldrum S, Saltos N, Boyle MJ, 'Induced sputum IL-8 gene expression, neutrophil influx and MMP-9 in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 21 582-588 (2003) [C1]
DOI 10.1183/09031936.03.00001803
Citations Scopus - 37Web of Science - 28
Co-authors Peter Gibson, Peter Wark
2002 Wark PA, Johnston S, Simpson JL, Hensley MJ, Gibson PG, 'Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma', The European Respiratory Journal, 20 834-840 (2002) [C1]
Citations Scopus - 50Web of Science - 42
Co-authors Peter Gibson, Michael Hensley, Peter Wark
2002 Wark PA, Johnston S, Moric I, Simpson JL, Hensley MJ, Gibson PG, 'Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma', The European Respiratory Journal, 19 68-75 (2002) [C1]
Citations Scopus - 203Web of Science - 179
Co-authors Peter Wark, Michael Hensley, Peter Gibson
2002 Wark PA, Simpson JL, Hensley MJ, Gibson PG, 'Airway inflammation in thunderstorm asthma', Clinical and Experimental Allergy, 32 1750-1756 (2002) [C1]
Citations Scopus - 27Web of Science - 21
Co-authors Peter Gibson, Peter Wark, Michael Hensley
2002 Simpson JL, Gibson PG, Wark PA, 'Optimization of sputum-processing methods for the measurement of interleukin-5: Effects of protease inhibition', Respirology, 7 111-116 (2002) [C1]
Citations Scopus - 8Web of Science - 10
Co-authors Peter Wark, Peter Gibson
2002 Chang A, Harrhy V, Simpson JL, Masters I, Gibson PG, 'Cough, airway inflammation, and mild asthma exacerbation', Archives of Disease in Childhood, 86 270-275 (2002) [C1]
Citations Scopus - 22Web of Science - 22
Co-authors Peter Gibson
2001 Gibson PG, Simpson J, Saltos N, 'Heterogeneity of Airway Inflammation in Persistant Asthma Evidence of Neturophilic Inflammation and Increased Sputum Interleukin-8', Chest, 119 1329-1336 (2001) [C1]
Citations Scopus - 321Web of Science - 279
Co-authors Peter Gibson
2001 Wark PA, Simpson J, Hensley MJ, Gibson PG, 'Safety of sputum induction with isotonic saline in adults with acute severe asthma', Clinical and Experimental Allergy, 31 1745-1753 (2001) [C1]
Citations Scopus - 27Web of Science - 23
Co-authors Peter Wark, Michael Hensley, Peter Gibson
2001 Jones PD, Hankin RG, Simpson J, Gibson PG, Henry R, 'The Tolerability, Safety, and Success of Sputum Induction and Combined Hypertonic Saline Challenge in Children', American Journal of Respiratory And Critical Care Medicine, 164 1146-1149 (2001) [C1]
Citations Scopus - 42Web of Science - 31
Co-authors Peter Gibson
2001 Gibson PG, Simpson J, Chalmers AC, Toneguzzi R, Wark PA, Wilson AJ, Hensley MJ, 'Airway Eosinophilia is associated with Wheeze but is uncommon in Children with Persistent Cough and Frequent Chest Colds', American Journal of Respiratory and Critical Care Medicine, 164 977-981 (2001) [C1]
Citations Scopus - 43Web of Science - 35
Co-authors Anita Chalmers, Amanda Wilson, Peter Wark, Michael Hensley, Peter Gibson
2001 Wark P, Simpson JL, Saltos N, Hensley MJ, Gibson PC, 'Itraconazole reduces eosinophilic airway inflammation in allergic bronchopulmonary aspergillosis (abpa)', Respirology, 6 (2001)

ABPA is an important complication of chronic asthma resulting from hypersensitivity to the fungus Aspergillus Fumigatus ( AF}. ABPA is characterised by an intense immune response ... [more]

ABPA is an important complication of chronic asthma resulting from hypersensitivity to the fungus Aspergillus Fumigatus ( AF}. ABPA is characterised by an intense immune response with increased use of oral steroids and potentially progressive lung disease. The aim of this study was to determine if treatment of subjects with ABPA with the antifungal agent Itraconazole (Itz) reduced airway and systemic inflammation. Methods: A randomised double blind placebo controlled trial was performed in stable subjects with ABPA (n=29). Subjects with cystic fibrosis ere excluded. The diagnosis of ABPA was based upon; the presence of asthma, IgE sensitisation to Af. a total serum IgE of lOOOIl'/mL or greater and serum IgG to Af or central bronchiectasis on CT scan. Subjects received Itz 400mg per day (n=15) or placebo (n=14) for 16 weeks. All subjects were reviewed monthly with history, spirometry. sputum induction to measure airway inflammation, serum total IgE and IgG to Af and blood eosinophils. Results: Subjects receiving Itz had a greater reduction in sputum eosinophils from baseline (median fall of 94.5%) compared to placebo (45.4%. p<0.01 ). Those on Itz had a fall in sputum total cell count from baseline (43.9%) compared to a rise in those on placebo (rise 10%. p=0.049). Subjects that received Itz also had a reduction in systemic immune activation; there was a fall in serum IgE (3IOIU/mL) compared to placebo (rise ISIU-'mL, p<0.01) and a fall in IgG to Af(15.4IU/mL) compared to placebo (rise 3.7IU-mL, p=0.03). Conclusion: Treatment of subjects with stable ABPA with Itz 400mg daily reduces eosinophilic airway inflammation along with measures of systemic immune activation. These results imply that Itz is a potential adjunctive treatment for ABPA and this should be further investigated with larger studies of lone term clinical efficacv.

Co-authors Michael Hensley
2001 Pab W, Simpson JL, 'Airway inflammation in acute asthma following a thunderstorm is associated with increased sputl'm eosinophilia and eosinophil degranulation', Respirology, 6 (2001)

Rationale: Epidemics of acute asthma associated with thunderstorms occur intermittently worldwide, though airway inflammation during these acute episodes has not been characterise... [more]

Rationale: Epidemics of acute asthma associated with thunderstorms occur intermittently worldwide, though airway inflammation during these acute episodes has not been characterised. The aim of this study was to characterise airway inflammation in acute thunderstorm asthma. Methods: Cases were recruited after presentation to the emergency room (ER) \vith acute asthma immediately following a thunderstorm (n=6). They were compared to controls that were atopic asthmatics that had presented with acute asthma to the ER prior to the thunderstorm. Subjects had spirometry, sputum induction and allergy skin tests acutely and at review 4 weeks later. Results: Thunderstorm (TS) cases were more likely to have a history of hay fever and less likely to be on inhaled steroids prior to presentation. Both groups had a similar degree of moderate to severe acute airways obstruction (p=l ,0). TS cases had elevated sputum eosinophils (14.8% of total cell count) compared to controls (1%, p < 0.01). TS cases had higher sputum eosinophil cationic protein (ECP) (11686ng/mL) compared to controls (1883, p=0.02) acutely. When adjusted for IS use, TS cases had a risk ratio for elevated sputum eosinophils of 2.3 (1.1-4.5). Conclusion: Airway inflammation in acute thunderstorm asthma is characterised by more sputum eosinophilia and eosinophil degranulation compared to other causes of acute asthma.

2000 Wark PA, Saltos N, Simpson J, Slater S, Hensley MJ, Gibson PG, 'Induced sputum easinophils and neutrophils and bronchiectasis severity in allergic bronchopulmonary aspergillosis', European Respiratory Journal, 16 1095-1101 (2000) [C1]
Citations Scopus - 51Web of Science - 39
Co-authors Michael Hensley, Peter Gibson, Peter Wark
2000 Norzila M, Fakes K, Henry R, Simpson J, Gibson PG, 'Interleukin-8 secretion and neutrophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma', American Journal of respiratory and Critical Care Medicine, 161 769-774 (2000) [C1]
Citations Web of Science - 135
Co-authors Peter Gibson
1999 Gibson PG, Norzila MZ, Fakes K, Simpson J, Henry RL, 'Pattern of airway inflammation and its determinants in children with acute severe asthma', PEDIATRIC PULMONOLOGY, 28 261-270 (1999)
DOI 10.1002/(SICI)1099-0496(199910)28:4<261::AID-PPUL5>3.0.CO;2-I
Citations Scopus - 61Web of Science - 45
Co-authors Peter Gibson
Show 78 more journal articles

Conference (84 outputs)

Year Citation Altmetrics Link
2014 Upham JW, Carroll M, Gibson P, Yang IA, Simpson J, 'Anti-Viral Innate Immunity Varies Across Different Asthma Inflammatory Phenotypes', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, San Diego, CA (2014) [E3]
Co-authors Peter Gibson
2014 Eckert B, Simpson J, Powell H, Pretto J, Upham J, Gibson P, 'EXHALED NITRIC OXIDE MEASUREMENT: INTER-INSTRUMENT VARIABILITY AND IMPLICATIONS ON TEST INTERPRETATION', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12262_16
Co-authors Peter Gibson
2014 Wright T, Gibson P, Simpson J, Mcdonald V, Wood L, Baines K, 'ALARMINS IN ASTHMA AND COPD: RELATIONSHIPS TO INFLAMMATORY PHENOTYPES AND DISEASE SEVERITY', RESPIROLOGY (2014) [E3]
Co-authors Lisa Wood, Peter Gibson, Katherine Baines, Vanessa Mcdonald
2014 Baines K, Simpson J, Wood L, Scott R, Fibbens N, Powell H, et al., 'SPUTUM GENE EXPRESSION OF SIX MARKERS IDENTIFIES ASTHMA INFLAMMATORY PHENOTYPE AND CORTICOSTEROID RESPONSE', RESPIROLOGY (2014) [E3]
Co-authors Lisa Wood, Rodney Scott, Katherine Baines
2014 Baines K, Upham J, Yerkovich S, Chang A, Marchant J, Carroll M, et al., 'INTERLEUKIN-1B IS RELATED TO CLINICAL OUTCOMES IN PROTRACTED BACTERIAL BRONCHITIS', RESPIROLOGY (2014) [E3]
Co-authors Peter Gibson, Katherine Baines
2014 Eckert B, Simpson J, Powell H, Pretto J, Upham J, Gibson P, 'EXHALED NITRIC OXIDE MEASUREMENT: INTER-INSTRUMENT VARIABILITY AND IMPLICATIONS ON TESTS INTERPRETATION', RESPIROLOGY (2014) [E3]
Co-authors Peter Gibson
2014 Simpson J, Gao P, Baines K, Yang I, Reynolds P, Hodge S, et al., 'GALECTIN 3 AND GALECTIN 3 BINDING PROTEIN IN ASTHMA INFLAMMATORY SUBTYPES', RESPIROLOGY (2014) [E3]
Co-authors Katherine Baines, Peter Gibson
2014 Simpson J, Carroll M, Gibson P, Yang I, Reynolds P, Hodge S, et al., 'REDUCED ANTI-VIRAL INNATE IMMUNITY IN PATIENTS WITH SEVERE ASTHMA IS ASSOCIATED WITH NEUTROPHILIC INFLAMMATION AND HIGH DOSE INHALED STEROIDS', RESPIROLOGY (2014) [E3]
Co-authors Peter Gibson
2013 Fu JJ, Mcdonald VM, Simpson JL, Higgins I, Mao B, Gibson PG, 'VALIDATION OF THE NEW GOLD COMBINED ASSESSMENT IN AN AUSTRALIAN COPD COHORT', RESPIROLOGY (2013) [E3]
Co-authors Isabel Higgins, Peter Gibson, Vanessa Mcdonald
2013 Gunawardhana LP, Baines KJ, Mattes J, Murphy VE, Simpson JL, Gibson PG, 'EPIGENETIC ALTERATIONS IN INFANTS ASSOCIATED WITH MATERNAL ASTHMA DURING PREGNANCY', RESPIROLOGY (2013) [E3]
Co-authors Peter Gibson, Joerg Mattes, Vanessa Murphy, Katherine Baines
2013 Powell H, Garside CG, Simpson JL, Yang IA, Reynolds PN, Hodge SJ, et al., 'CHARACTERISTICS OF UNCONTROLLED ASTHMA IN AUSTRALIA', RESPIROLOGY (2013) [E3]
Co-authors Peter Gibson
2013 Simpson JL, Yang IA, Reynolds PN, Hodge SJ, James AL, Upham J, et al., 'ALTERNATIVES TO INDUCED SPUTUM FOR IDENTIFYING PATIENTS WITH EOSINOPHILIC ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Peter Gibson
2013 Simpson JL, Baines KJ, Ryan NM, Gibson PG, 'NEUTROPHILIC ASTHMA IS CHARACTERIZED BY INCREASED GERD AND RHINOSINUSITIS WITH SLEEP DISTURBANCE', RESPIROLOGY (2013) [E3]
Co-authors Nicole Ryan, Katherine Baines, Peter Gibson
2013 Zhong H, Simpson JL, Wood LG, Wark PAB, 'COPD PERIPHERAL BLOOD NEUTROPHILS HAVE ENHANCED RELEASE OF IL-1B WHEN STIMULATED', RESPIROLOGY (2013) [E3]
Co-authors Lisa Wood, Peter Wark
2013 Baines KJ, Simpson JL, Mcdonald VM, Hsu AC, Gibson PG, 'DIFFERENTIAL AIRWAY GENE EXPRESSION IN COPD', RESPIROLOGY (2013) [E3]
Co-authors Vanessa Mcdonald, Alan Hsu, Peter Gibson, Katherine Baines
2013 Thasneem A, Simpson JL, Pradeepan S, 'OVERLAP SYNDROME-PREVALENCE, CHARACTERISTICS AND PREDICTORS', RESPIROLOGY (2013) [E3]
2012 Fu J, McDonald VM, Gibson PG, Simpson JL, 'Systemic inflammation in older adults with asthma-COPD overlap syndrome', Abstracts. European Respiratory Society Annual Congress 2012, Vienna (2012) [E3]
Co-authors Peter Gibson, Vanessa Mcdonald
2012 Simpson JL, Phipps S, Baines KJ, Oreo KM, Gibson PG, 'NALP3 INFLAMMASOME ACTIVATION IN NEUTROPHILIC ASTHMA', RESPIROLOGY (2012) [E3]
Co-authors Peter Gibson, Katherine Baines
2012 Garside CG, Simpson JL, Yang IA, Reynolds PN, Hodge SJ, James AL, et al., 'Inflammatory subtypes of uncontrolled asthma in Australia', Respirology, Canberra, ACT (2012) [E3]
Co-authors Peter Gibson
2012 McDonald VM, Fu J, Simpson JL, Gibson PG, 'The longitudinal determinants of decline in obstructive airway diseases', Respirology, Canberra, ACT (2012) [E3]
Co-authors Vanessa Mcdonald, Peter Gibson
2012 Zhong H, Simpson JL, Wood LG, Wark PA, 'Activation of human neutrophils exposed to cigarette smoke extract: A comparison of COPD patients versus healthy non-smokers', Respirology, Canberra, ACT (2012) [E3]
Co-authors Lisa Wood, Peter Wark
2012 See HV, Simpson JL, Hansbro PM, Wark PA, 'Stable COPD patients have less rhinovirus-induced intracellular innate cytokines detected in PBMCS compared to healthy adults', Respirology, Canberra, ACT (2012) [E3]
Co-authors Philip Hansbro, Peter Wark
2012 Simpson JL, Phipps S, Baines KJ, Oreo K, Gibson PG, 'NALP3 inflammasome activation in neutrophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authors Katherine Baines, Peter Gibson
2012 Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL, 'Assessment of the relationship between airway neutrophilia and aging in asthmatics and non-asthmatics', Respirology, Hong Kong (2012) [E3]
Co-authors Peter Gibson
2012 Zhong H, Simpson JL, Wood LG, Wark PA, 'Different responses of blood neutrophils from COPD', Respirology, Hong Kong (2012) [E3]
Co-authors Peter Wark, Lisa Wood
2012 Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Sputum gene expression of mast cell specific proteases are increased in eosinophilic asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authors Peter Gibson, Lisa Wood, Rodney Scott, Katherine Baines
2012 Baines KJ, Simpson JL, Wood LG, Scott RJ, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', Respirology, Canberra, ACT (2012) [E3]
Co-authors Lisa Wood, Peter Gibson, Rodney Scott, Katherine Baines
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Systemic upregulation of neutrophil a-defensins and serine proteases in neutrophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authors Lisa Wood, Peter Gibson, Katherine Baines, Rodney Scott
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Sputum gene expression of mast cell tryptase and carboxypeptidase A3 are increased in eosinophilic asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authors Lisa Wood, Peter Gibson, Rodney Scott, Katherine Baines
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma', European Respiratory Society Annual Congress 2011 Abstracts, Amsterdam (2011) [E3]
Co-authors Katherine Baines, Rodney Scott, Lisa Wood, Peter Gibson
2011 Hansbro PM, Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, et al., 'Infection-induced neutrophilic allergic airways disease is resistant to steroid treatment', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Philip Hansbro, Margaret Dunkley, Peter Gibson, Paul Foster, Jay Horvat
2011 Sukkar MB, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Deficiency of srage in asthma and COPD is selectively associated with neutrophilic airway inflammation', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
Co-authors Peter Gibson, Lisa Wood, Vanessa Mcdonald, Peter Wark
2011 Sukkar M, Wood LG, Tooze MK, Simpson JL, McDonald VM, Gibson PG, Wark PA, 'Soluble RAGE is deficient in neutrophilic asthma and COPD', Respirology, Perth, WA (2011) [E3]
DOI 10.1183/09031936.00022011
Citations Scopus - 45Web of Science - 39
Co-authors Vanessa Mcdonald, Peter Gibson, Lisa Wood, Peter Wark
2011 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Peter Gibson, Katherine Baines, Rodney Scott, Lisa Wood
2011 Garside CG, Simpson JL, Yang IA, James AL, Upham JW, Reynolds PN, et al., 'Characterizing the severe asthma phenotype in an Australian setting: The Amazes Study', Respirology, Perth, WA (2011) [E3]
Co-authors Peter Gibson
2011 Gunawardhana LP, Baines KJ, Simpson JL, Mattes J, Murphy VE, Gibson PG, 'Maternal asthma is associated with alterations in DNA methylation profile of peripheral blood of infants', Respirology, Perth, WA (2011) [E3]
Co-authors Joerg Mattes, Vanessa Murphy, Peter Gibson, Katherine Baines
2011 Hodge S, Richard S, Simpson JL, Garside CG, Herewane K, Yang I, et al., 'Granzyme B is increased in induced sputum both from patients with COPD and non-eosinophilic asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Peter Gibson
2011 Hodge S, Simpson JL, Richard S, Garside CG, Yang I, Upham J, et al., 'Non-eosinophilic asthma resembles COPD with suppressed apoptotic cell clearance and macrophage recognition molecules', Respirology, Perth, WA (2011) [E3]
Co-authors Peter Gibson
2011 Horvat JC, Essilfie A-T, Kim RY, Simpson JL, Dunkley ML, Beagley KW, et al., 'Investigation of infection-induced steroid resistant asthma', Respirology, Perth, WA (2011) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Jay Horvat, Paul Foster, Peter Gibson
2011 See HV, Simpson JL, Hansbro PM, Wark PA, 'COPD patients PBMCS have an impaired immune response to phinovirus-infected bronchial epithelium', Respirology, Perth, WA (2011) [E3]
Co-authors Philip Hansbro, Peter Wark
2011 Zhong H, Tooze MK, Wood LG, Simpson JL, Wark PA, 'Effect of cigarette smoke extract on neutrophils isolated from human peripheral blood', Respirology, Perth, WA (2011) [E3]
Co-authors Lisa Wood, Peter Wark
2011 Wang F, Xy HA, Baines KJ, Gunawardhana LP, Simpson JL, Ki F, Gibson PG, 'Is chalamydophyla a pneumoniae infection related to non-eosinophilic asthma?', Respirology, Perth, WA (2011) [E3]
Co-authors Katherine Baines, Peter Gibson
2011 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Mucus hypersecretion and chronic bronchitis in older adults with chronic obstructive airway diseases', Respirology, Shanghai (2011) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Peter Gibson
2010 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Horvat JC, Gibson PG, Foster PS, 'Haemophilus influenzae induces IL-17-mediated neutrophilic allergic airways disease', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
Citations Scopus - 39Web of Science - 35
Co-authors Peter Gibson, Paul Foster, Philip Hansbro, Margaret Dunkley, Jay Horvat
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', American Journal of Respiratory and Critical Care Medicine, New Orleans, LO (2010) [E3]
Co-authors Katherine Baines, Rodney Scott, Peter Gibson, Lisa Wood
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Analysis of systemic gene expression according to inflammatory phenotype of asthma', Biomarker Discovery Conference, Shoal Bay, NSW (2010) [E3]
Co-authors Lisa Wood, Katherine Baines, Rodney Scott, Peter Gibson
2010 McDonald VM, Higgins IJ, Simpson JL, Gibson PG, 'Is there an association between self reported activity limitation and exercise tolerance in COPD?', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Peter Gibson
2010 McDonald VM, Higgins IJ, Simpson JL, Gibson PG, 'Six minute walk tests: Are practice tests necessary?', European Respiratory Society Annual Congress 2010. Abstracts, Barcelona, Spain (2010) [E3]
Co-authors Vanessa Mcdonald, Peter Gibson, Isabel Higgins
2010 Baines KJ, Simpson JL, Scott RJ, Wood LG, Gibson PG, 'Molecular profiling of asthma defined by gene expression', Respirology, Brisbane, QLD (2010) [E3]
Co-authors Peter Gibson, Lisa Wood, Katherine Baines
2010 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Molecular phenotypes of asthma defined by gene expression profiling', Respirology, Brisbane, QLD (2010) [E3]
Co-authors Katherine Baines, Rodney Scott, Lisa Wood, Peter Gibson
2010 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'Is there an association between self reported acitivity limitation and exercise tolerance in COPD?', Respirology, Brisbane, QLD (2010) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Peter Gibson
2010 Simpson JL, McDonald VM, Gibson PG, 'The relationship between systemic inflammation, airway inflammation and airway obstruction in COPD', Respirology, Brisbane, QLD (2010) [E3]
Co-authors Vanessa Mcdonald, Peter Gibson
2010 Simpson JL, McDonald VM, Gibson PG, 'Exhaled nitric oxide is not a marker of eosinophilic inflammation in older Australians', Respirology, Brisbane, QLD (2010) [E3]
Co-authors Vanessa Mcdonald, Peter Gibson
2009 Baines KJ, Simpson JL, Scott R, Wood LG, Gibson PG, 'Genome wide gene expression of induced sputum in non-eosinophilic asthma', AMATA 2009, Katoomba, NSW (2009) [E3]
Co-authors Lisa Wood, Peter Gibson, Rodney Scott, Katherine Baines
2009 Wark PA, See HV, Simpson JL, Vanders RL, Hansbro PM, 'Peripheral blood monocytes (PBMCs) display innate antiviral response to rhinovirus (RV) infected bronchial epithelial cells', Journal of Immunology, Seattle, WASH. (2009) [E3]
Co-authors Peter Wark, Philip Hansbro
2009 McDonald VM, McElduff P, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional problem assessment of asthma and COPD in an older population: Patient-physician concordance', European Respiratory Journal, Vienna, Austria (2009) [E3]
Co-authors Isabel Higgins, Vanessa Mcdonald, Peter Gibson
2009 McDonald VM, McElduff P, Simpson JL, Higgins IJ, Gibson PG, 'Multidimensional clinical problem assessment in asthma and COPD: Patient-physician concordance', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01502_7.x
Co-authors Peter Gibson, Vanessa Mcdonald, Isabel Higgins
2009 Oldham RA, Simpson JL, Hansbro PM, Gibson PG, 'Increased bacterial load and colonisation in COPD', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Philip Hansbro, Peter Gibson
2009 Simpson JL, Gibson PG, Reynolds PN, Hodge S, 'Impaired macrophage phagocytosis in non-eosinophilic asthma', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Gibson
2009 Oreo K, Baines KJ, Gibson PG, Hansbro PM, Simpson JL, 'Toll-like receptor agonists stimulate cytokine release from blood but not airway cells', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Peter Gibson, Katherine Baines, Philip Hansbro
2009 Essilfie A-T, Simpson JL, Dunkley ML, Foster PS, Gibson PG, Hansbro PM, 'Haemophilus influenzae infection induces features of neutrophilic asthma', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Paul Foster, Peter Gibson, Philip Hansbro, Margaret Dunkley
2009 Wark PA, Oldham RA, Brooks C, Simpson JL, Douwes J, 'Airway neutrophilia in chronic obstructive pulmonary disease (COPD) and asthma are associated with lower lung function and the presence of pathogenic bacteria', Respirology, Darwin, NT (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01502_7.x
Co-authors Peter Wark
2008 Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation and inflammatory subtype in older people with COPD', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]
Co-authors Peter Gibson, Philip Hansbro, Vanessa Mcdonald
2008 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Ageing alters airway and circulating neutrophil function', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Rodney Scott, Peter Gibson, Katherine Baines
2008 Baines KJ, Simpson JL, Scott R, Gibson PG, 'Innate immune responses of airway neutrophils are impaired in neutrophilic asthma', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Rodney Scott, Peter Gibson, Katherine Baines
2008 Essilfie A-T, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Haemophilus influenzae (Hi) infection in asthma may drive the development of neutrophilic asthma (NA)', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Jay Horvat, Paul Foster, Peter Gibson, Philip Hansbro, Margaret Dunkley
2008 Wark PA, Oldham RA, Simpson JL, Douwes J, 'Endotoxin levels are higher in the bronchoalveolar lavage of ex-smokers compared to never smokers', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Peter Wark
2008 Simpson JL, Hansbro PM, McDonald VM, Gibson PG, 'Age and disease related changes in airway inflammation in older people with COPD', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Vanessa Mcdonald, Peter Gibson, Philip Hansbro
2008 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'A problem based assessment of asthma and COPD in an older population', Respirology, Melbourne, VIC (2008) [E3]
DOI 10.1111/j.1440-1843.2008.01252.x
Co-authors Vanessa Mcdonald, Isabel Higgins, Peter Gibson
2008 Hansbro PM, Essilfie A-T, Simpson JL, Dunkley ML, Gibson PG, Foster PS, 'Haemophilus influenzae (HI) infection induces features of neutrophilic asthma', Australasian Society for Immunology 38th Annual Scientific Meeting: Delegate Book, Canberra, ACT (2008) [E3]
Co-authors Margaret Dunkley, Philip Hansbro, Paul Foster, Peter Gibson
2007 Baines KJ, Bowden NA, Scott R, Simpson JL, Gibson PG, 'Molecular analysis of neutrophils in asthma subtypes', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Katherine Baines, Nikola Bowden, Rodney Scott, Peter Gibson
2007 McDonald VM, Simpson JL, Higgins IJ, Gibson PG, 'A problem based assessment of obstructive airways disease (OAD) in an elderly population', European Respiratory Society Annual Congress 2007. Abstracts, Stockholm (2007) [E3]
Co-authors Vanessa Mcdonald, Isabel Higgins, Peter Gibson
2007 Essiflie A, Preston JA, Horvat JC, Dunkley ML, Foster PS, Gibson PG, et al., 'Elucidating the association between Haemophilus influenzae infection and neutrophilic allergic airways disease using mouse models', Immuno 2007: 13th International Congress of Immunology. Abstracts and Posters, Rio de Janeiro, Brazil (2007) [E3]
Co-authors Peter Gibson, Margaret Dunkley, Philip Hansbro, Paul Foster, Jay Horvat
2007 Simpson JL, Hansbro PM, Kenyon ME, Gibson PG, 'Remodelled asthma in the elderly: is asthma turning into COPD?', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authors Philip Hansbro, Peter Gibson
2007 Simpson JL, Milne DG, Gibson PG, 'Radiographic differences between neutrophilic asthma, COPD and smokers using HRCT', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authors Peter Gibson
2007 Simpson JL, Powell H, Boyle MJ, Scott R, Gibson PG, 'Anti-inflammatory effects of clarithromycin in refractory non-eosinophilic asthma', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
DOI 10.1111/j.1440-1843.2007.001050.x
Co-authors Rodney Scott, Peter Gibson
2007 Timmins NL, Wood LG, Simpson JL, Gibson PG, 'Optimising exhaled breath condensate collection', Respirology (TSANZ Abstracts-Posters), Auckland (2007) [E3]
Co-authors Peter Gibson, Lisa Wood
2006 Simpson JL, Scott R, Boyle MJ, Oldham RA, Gibson PG, 'IL-8 levels ininflammatory subtypes of airway disease', Respirology, Canberra (2006) [E3]
Co-authors Rodney Scott, Peter Gibson
2006 Mattes J, Simpson JL, Foster PS, Gibson PG, 'Trail is upregulated in the airways of asthmatics', Respirology, Canberra (2006) [E3]
Co-authors Joerg Mattes, Peter Gibson, Paul Foster
2006 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in asthma with fixed airflow obstruction', Respirology, Canberra (2006) [E3]
Co-authors Rodney Scott, Peter Gibson
2006 Baines KJ, Simpson JL, Scott R, Bell NV, Boyle MJ, Gibson PG, 'Enhanced IL-8 release from neutrophils in non-eosinophilic asthma', Respirology, Canberra (2006) [E3]
Co-authors Peter Gibson, Katherine Baines, Rodney Scott
2006 Simpson JL, Grissell TV, Douwes J, Scott R, Boyle MJ, Gibson PG, 'Innate immune activation in neutrophilic asthma', The Journal of the Japanese Respiratory Society, Tokyo (2006) [E3]
Co-authors Rodney Scott, Peter Gibson
2006 Simpson JL, Scott R, Boyle MJ, Gibson PG, 'Inflammatory subtypes in Asthma with fixed airflow obstruction', American Thoracic Society. Proceedings, San Diego, California (2006) [E3]
Co-authors Peter Gibson, Rodney Scott
2005 Wood LG, Garg ML, Blake RJ, Simpson JL, Gibson PG, 'Systemic and airway levels of glutathione and alpha-tocopherol in asthma', Asia Pacific Journal of Clinical Nutrition, Australia (2005) [E3]
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
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Grants and Funding

Summary

Number of grants 38
Total funding $5,979,078

Click on a grant title below to expand the full details for that specific grant.


20152 grants / $26,222

Characterising the airway and gut microbiome in severe asthma$25,222

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Associate Professor Jodie Simpson, Conjoint Associate Professor Nick Saltos, Professor Phil Hansbro
Scheme Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500009
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

TZANZ Meeting, Gold Coast Australia, 27 March-1 April 2015$1,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500397
Type Of Funding Internal
Category INTE
UON Y

20143 grants / $53,078

Galectin 3 reduced in non-eosinophilic asthma and associated with impaired macrophage efferocytosis and sputum neutrophil numbers$27,512

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Associate Professor Jodie Simpson, Doctor David Arnold
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400460
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Miltenyi Biotec GentleMACS Octo Dissociator with Heaters $23,566

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Darryl Knight, Professor Dirk Van Helden, Professor Joerg Mattes, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Associate Professor Liz Milward, Dr NATHAN Bartlett, Doctor Simon Keely, Doctor Steven Maltby, Doctor Andrew Jarnicki, Doctor Malcolm Starkey, Doctor Adam Collison, Ms Shaan Gellatly
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500861
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Thoracic Society of Australia and New Zealand Annual Meeting, Adelaide Australia, 4-9 April 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400494
Type Of Funding Internal
Category INTE
UON Y

20135 grants / $1,213,078

Inflammometry in Stable COPD; A Randomised Controlled Trial (RCT)$717,071

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Professor Peter Wark
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200185
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$449,307

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200188
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201180
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

ASI 2013, Wellington Australia, 2 - 5 December 2013$1,700

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1301220
Type Of Funding Internal
Category INTE
UON Y

20122 grants / $35,076

Body plethysmograph respiratory function system$33,076

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100973
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Asian Pacific Society of Respirology, Hong Kong, 14- 16 December 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200874
Type Of Funding Internal
Category INTE
UON Y

20113 grants / $57,700

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson
Scheme Research Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100635
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Identification of a specific biomarker signature that identifies asthma phenotype $23,700

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1001054
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100038
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20102 grants / $274,000

The pathogenesis of distinct endophenotypes of asthma is underpinned by the collaborative activation of specific PRRs$240,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jodie Simpson, Dr Simon Phipps
Scheme Project Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0190179
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
Scheme Equipment Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000056
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20094 grants / $3,091,854

The AMAZES study: asthma and macrolides: the AZithromycin efficacy and safety study$2,991,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Professor John Upham, Associate Professor Paul Reynolds, Dr Ian Yang, Dr Sandra Hodge
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0188843
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Doctor Katie Baines, Associate Professor Jodie Simpson
Scheme PhD Scholarships
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189748
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

394591 ELx405UV select plate washer and workstation integration kit$27,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Doctor Xiao Yan He, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Conjoint Professor Peter Wark
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189853
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

PULSE Early Career Researcher of the year$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Jodie Simpson
Scheme PULSE Early Career Researcher of the Year Award
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189893
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20085 grants / $601,500

Molecular mechanisms and treatment of non-eosinophilic asthma$300,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Jodie Simpson, Doctor Katie Baines
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188825
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Characterisation and treatment of innate immune dysfunction in older people with obstructive airway disease$254,000

Funding body: Australian Respiratory Council

Funding body Australian Respiratory Council
Project Team Associate Professor Jodie Simpson
Scheme Ann Woolcock Fellowship
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188282
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Professor Phil Hansbro
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188547
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Understanding non-eosinophilic asthma: triggers and treatment$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188559
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

American Thoracic Society Annual Meeting, Toronto, Canada, 16/5/2008 - 21/5/2008$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188580
Type Of Funding Internal
Category INTE
UON Y

20078 grants / $607,488

Characterisation and Treatment of Innate Immune Dysfunction in Older People with Obstructive Airway Disease$416,875

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Professor Phil Hansbro
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0186426
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

In vitro response of bronchial epithelial cells and activation of lymphocytes to infection with rhinovirus$58,848

Funding body: John Hunter Hospital Charitable Trust Fund

Funding body John Hunter Hospital Charitable Trust Fund
Project Team Conjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
Scheme Research Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188095
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Nitric Oxide Monitoring System (NIOX)$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Emeritus Professor Michael Hensley, Doctor Vanessa Murphy, Conjoint Professor Peter Wark, Associate Professor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Associate Professor Bruce Whitehead, Laureate Professor Paul Foster, Professor Phil Hansbro, Associate Professor Lisa Wood
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188193
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

In vitro response of bronchial epithelial cells and activation of lymphocytes from COPD patients by infection with rhinovirus, respiratory syncytial virus and haemophilus influenza$25,000

Funding body: GlaxoSmithKline Australia

Funding body GlaxoSmithKline Australia
Project Team Conjoint Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson
Scheme Support Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188309
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Elucidation of the association between Haemophilus influenzae infection and neutrophilic asthma.$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Phil Hansbro, Associate Professor Jodie Simpson, Laureate Professor Paul Foster, Conjoint Professor Margaret Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187206
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Hewlett Packard 7890 series gas chromatograph with accessories$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Lisa Wood, Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Laureate Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188191
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Laureate Professor Paul Foster, Professor Phil Hansbro
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188192
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Thoracic Society of Australia and New Zealand, 23-28/3/07$1,765

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187371
Type Of Funding Internal
Category INTE
UON Y

20064 grants / $19,082

Airway inflamation in people over 55$11,682

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Jodie Simpson
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186232
Type Of Funding Internal
Category INTE
UON Y

American Thoracic Society International Scientific meeting$3,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Jodie Simpson
Scheme PULSE Education Prize
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186155
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

American Thoracic society Annual Meeting 19-24 MAY 2006$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186471
Type Of Funding Internal
Category INTE
UON Y

American Thoracic Society conference$2,000

Funding body: Ian Potter Foundation

Funding body Ian Potter Foundation
Project Team Associate Professor Jodie Simpson
Scheme Travel Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186176
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2014 The Effects of Galectin-3 on Alveolar Macrophage Function in Asthma
General Medicine, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2015 Characterising Innate Immune Responses and the Role of PD-1 in Patients with COPD
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2014 Epigenetic Regulation of Airway Inflammation in Asthma
General Medicine, Faculty of Health and Medicine
Co-Supervisor
2012 Modulation of Responses in Allergic Airways Disease by Haemophilus Influenzae Infection
Microbiology, Faculty of Health and Medicine
Co-Supervisor
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News

Associate Professor Jodie Simpson

UON researcher selected for Aust-China Scientist Exchange Program

November 14, 2014

Associate Professor Jodie Simpson from the University of Newcastle's Priority Research Centre for Asthma and Respiratory Diseases will visit China from 18 November to 5 December 2014 on the Australia-China Young Scientists Exchange Program.

Young reseracher of the year, Jodie Simpson

Young Researcher of the Year

September 16, 2013

Asthma researcher scores prestigious Scopus award

Associate Professor Jodie Simpson

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Email jodie.simpson@newcastle.edu.au
Phone (02) 40420148
Fax (02) 4985 5850

Office

Room HMRI Level 2 Room 2101
Building HMRI
Location HMRI

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