Staff Profile
Edit
Career Summary
Biography
Jodie Simpson is a senior research fellow in The University of Newcastle’s Priority Research Centre for Asthma and Respiratory Disease and the current holder of the Australian Respiratory Council’s Ann Woolcock Research Fellowship. Her research focuses on the inflammatory biomarkers of airways disease and she has a particular interest in innate immune pathways and their role in airways disease. She has developed several important assays for the assessment of inflammatory mediators in airway secretions and continues to work on assessment of novel markers of airway inflammation. In 2005, Jodie completed her PhD where she identified and characterised four inflammatory phenotypes in asthma based on the presence of absence of increased sputum eosinophil and neutrophil proportions. This work has led to further investigations of asthma inflammatory phenotypes using gene expression profiling and recently the identification of novel biomarkers for asthma and COPD.
Dr Simpson designed and conducted the first RCT of macrolide antibiotics in severe refractory asthma, this research was pivotal in her success with a large NHMRC project grant awarded in 2008 to investigate macrolide antibiotic therapy in asthma as a multi-centre RCT (The AMAZES study). In her earlier work, Dr Simpson demonstrated that macrolide antibiotics are an effective anti-inflammatory therapy in non-eosinophilic refractory asthma. She is currently working on the AMAZES study collaborating with centres around Australia and working on 2 sub-studies, the first looking at macrophage phagocytosis and the second investigating airway and systemic inflammation in asthma subtypes.
Jodie has actively presented her work at national and international scientific meetings and has authored over 50 papers in peer reviewed journals. She is an active participant in research service and teaching as representative on TSANZ research subcommittee and the supervisor of 4 research higher degree students.
Qualifications
- PhD (Medicine), University of Newcastle, 13/08/2005
- Bachelor of Science, University of Newcastle, 09/05/1997
- Bachelor of Science (Honours), University of Newcastle, 01/05/1998
Research
Research keywords
- COPD
- asthma
- clinical trials
- immune response
- inflammation
Research expertise
Jodie Simpson is a senior research fellow in The University of Newcastle’s Priority Research Centre for Asthma and Respiratory Disease and the current holder of the Australian Respiratory Council’s Ann Woolcock Research Fellowship. Her research focuses on the inflammatory biomarkers of airways disease and she has a particular interest in innate immune pathways and their role in airways disease
Languages
- English
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 110203 | Respiratory Diseases | 100 |
Memberships
Body relevant to professional practice.
- American Thoracic Society
- Thoracic Society of Australia and New Zealand
Teaching
Teaching keywords
- asthma and COPD
- induced sputum
- inflammatory mediators
Edit
- Indicates that the researcher may be seeking students for this project.Inflammometry in Stable COPD; A Randomised Controlled Trial (RCT)$717,071
Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$449,307
BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000
DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Body plethysmograph respiratory function system$33,076
Asian Pacific Society of Respirology, Hong Kong, 14- 16 December 2012$2,000
Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000
Identification of a specific biomarker signature that identifies asthma phenotype
$23,700
Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000
The pathogenesis of distinct endophenotypes of asthma is underpinned by the collaborative activation of specific PRRs$240,000
Real time PCR machine (Mastercycler ep realplex2 from Epprndorf)
$34,000
The AMAZES study: asthma and macrolides: the AZithromycin efficacy and safety study$2,991,000
Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354
394591 ELx405UV select plate washer and workstation integration kit$27,500
PULSE Early Career Researcher of the year$10,000
Molecular mechanisms and treatment of non-eosinophilic asthma$300,000
Characterisation and treatment of innate immune dysfunction in older people with obstructive airway disease$254,000
Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000
Understanding non-eosinophilic asthma: triggers and treatment$10,000
American Thoracic Society Annual Meeting, Toronto, Canada, 16/5/2008 - 21/5/2008$2,500
Characterisation and Treatment of Innate Immune Dysfunction in Older People with Obstructive Airway Disease$416,875
In vitro response of bronchial epithelial cells and activation of lymphocytes to infection with rhinovirus$58,848
Nitric Oxide Monitoring System (NIOX)$45,000
In vitro response of bronchial epithelial cells and activation of lymphocytes from COPD patients by infection with rhinovirus, respiratory syncytial virus and haemophilus influenza$25,000
Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000
Elucidation of the association between Haemophilus influenzae infection and neutrophilic asthma.$20,000
Hewlett Packard 7890 series gas chromatograph with accessories$20,000
Thoracic Society of Australia and New Zealand, 23-28/3/07$1,765
Airway inflamation in people over 55$11,682
American Thoracic Society International Scientific meeting$3,000
American Thoracic society Annual Meeting 19-24 MAY 2006$2,400
American Thoracic Society conference$2,000
Grants and Funding
Summary
| Number of grants | 32 |
|---|---|
| Total funding | $5,898,078 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2013 (4 grants)
Inflammometry in Stable COPD; A Randomised Controlled Trial (RCT)$717,071
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Doctor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Associate Professor Peter Wark | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $717,071 | 2013 | 2016 |
| GNo:G1200185 | ||
Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$449,307
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $449,307 | 2013 | 2015 |
| GNo:G1200188 | ||
BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Associate Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,000 | 2013 | 2013 |
| GNo:G1201180 | ||
DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Mr Andrew Jarnicki, Doctor Michael Fricker | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2013 | 2013 |
| GNo:G1201186 | ||
2012 (2 grants)
Body plethysmograph respiratory function system$33,076
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Conjoint Associate Professor Peter Wark, Associate Professor Lisa Wood, Associate Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Mr Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $33,076 | 2012 | 2012 |
| GNo:G1100973 | ||
Asian Pacific Society of Respirology, Hong Kong, 14- 16 December 2012$2,000
Funding Body: University of Newcastle - Faculty of Health
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,000 | 2012 | 2013 |
| GNo:G1200874 | ||
2011 (3 grants)
Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000
Funding Body: John Hunter Hospital Charitable Trust Fund
| Project Team | ||
|---|---|---|
| Doctor Katie Baines, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $24,000 | 2011 | 2011 |
| GNo:G1100635 | ||
Identification of a specific biomarker signature that identifies asthma phenotype
$23,700
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Katie Baines, Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $23,700 | 2011 | 2011 |
| GNo:G1001054 | ||
Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Katie Baines, Conjoint Associate Professor Peter Wark, Doctor Vanessa Murphy | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2011 | 2011 |
| GNo:G1100038 | ||
2010 (2 grants)
The pathogenesis of distinct endophenotypes of asthma is underpinned by the collaborative activation of specific PRRs$240,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson, Dr Simon Phipps | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $240,000 | 2010 | 2012 |
| GNo:G0190179 | ||
Real time PCR machine (Mastercycler ep realplex2 from Epprndorf)
$34,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Associate Professor Peter Wark, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines | ||
| Scheme | Role | |
| Equipment Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $34,000 | 2010 | 2010 |
| GNo:G1000056 | ||
2009 (4 grants)
The AMAZES study: asthma and macrolides: the AZithromycin efficacy and safety study$2,991,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Professor John Upham, Associate Professor Paul Reynolds, Dr Ian Yang, Dr Sandra Hodge | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,991,000 | 2009 | 2013 |
| GNo:G0188843 | ||
Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354
Funding Body: Asthma Foundation of New South Wales
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Doctor Katie Baines, Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| PhD Scholarships | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $63,354 | 2009 | 2011 |
| GNo:G0189748 | ||
394591 ELx405UV select plate washer and workstation integration kit$27,500
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Doctor Xiao Yan He, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Conjoint Associate Professor Peter Wark | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $27,500 | 2009 | 2009 |
| GNo:G0189853 | ||
PULSE Early Career Researcher of the year$10,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| PULSE Early Career Medical Researcher of the Year Award | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2009 | 2009 |
| GNo:G0189893 | ||
2008 (5 grants)
Molecular mechanisms and treatment of non-eosinophilic asthma$300,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson, Doctor Katie Baines | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $300,000 | 2008 | 2010 |
| GNo:G0188825 | ||
Characterisation and treatment of innate immune dysfunction in older people with obstructive airway disease$254,000
Funding Body: Australian Respiratory Council
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Ann Woolcock Fellowship | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $254,000 | 2008 | 2011 |
| GNo:G0188282 | ||
Becton Dickinson high throughout sampler for the FACSCanto II cytometry system$35,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Associate Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Doctor Vanessa Murphy, Professor Phil Hansbro | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $35,000 | 2008 | 2008 |
| GNo:G0188547 | ||
Understanding non-eosinophilic asthma: triggers and treatment$10,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2008 | 2008 |
| GNo:G0188559 | ||
American Thoracic Society Annual Meeting, Toronto, Canada, 16/5/2008 - 21/5/2008$2,500
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,500 | 2008 | 2008 |
| GNo:G0188580 | ||
2007 (8 grants)
Characterisation and Treatment of Innate Immune Dysfunction in Older People with Obstructive Airway Disease$416,875
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson, Conjoint Professor Peter Gibson, Professor Phil Hansbro | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $416,875 | 2007 | 2009 |
| GNo:G0186426 | ||
In vitro response of bronchial epithelial cells and activation of lymphocytes to infection with rhinovirus$58,848
Funding Body: John Hunter Hospital Charitable Trust Fund
| Project Team | ||
|---|---|---|
| Conjoint Associate Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $58,848 | 2007 | 2009 |
| GNo:G0188095 | ||
Nitric Oxide Monitoring System (NIOX)$45,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Peter Gibson, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Emeritus Professor Michael Hensley, Doctor Vanessa Murphy, Conjoint Associate Professor Peter Wark, Doctor Vanessa McDonald, Associate Professor Jodie Simpson, Conjoint Associate Professor Bruce Whitehead, Professor Paul Foster, Professor Phil Hansbro, Associate Professor Lisa Wood | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $45,000 | 2007 | 2007 |
| GNo:G0188193 | ||
In vitro response of bronchial epithelial cells and activation of lymphocytes from COPD patients by infection with rhinovirus, respiratory syncytial virus and haemophilus influenza$25,000
Funding Body: GlaxoSmithKline Australia
| Project Team | ||
|---|---|---|
| Conjoint Associate Professor Peter Wark, Professor Phil Hansbro, Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Support Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,000 | 2007 | 2008 |
| GNo:G0188309 | ||
Class II biohazard containment hood and carbon dioxide cell culture incubator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Associate Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Associate Professor Lisa Wood, Professor Paul Foster, Professor Phil Hansbro | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2007 | 2007 |
| GNo:G0188192 | ||
Elucidation of the association between Haemophilus influenzae infection and neutrophilic asthma.$20,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Professor Phil Hansbro, Associate Professor Jodie Simpson, Professor Paul Foster, Conjoint Professor Margaret Dunkley | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2007 | 2007 |
| GNo:G0187206 | ||
Hewlett Packard 7890 series gas chromatograph with accessories$20,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Associate Professor Lisa Wood, Conjoint Associate Professor Peter Wark, Conjoint Professor Peter Gibson, Associate Professor Jodie Simpson, Doctor Vanessa Murphy, Professor Paul Foster, Professor Phil Hansbro, Conjoint Associate Professor Vicki Clifton, Professor Clare Collins, Conjoint Professor Wayne Smith, Professor John Attia | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2007 | 2007 |
| GNo:G0188191 | ||
Thoracic Society of Australia and New Zealand, 23-28/3/07$1,765
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $1,765 | 2007 | 2007 |
| GNo:G0187371 | ||
2006 (4 grants)
Airway inflamation in people over 55$11,682
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Early Career Researcher Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $11,682 | 2006 | 2006 |
| GNo:G0186232 | ||
American Thoracic Society International Scientific meeting$3,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| PULSE Education Prize | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $3,000 | 2006 | 2006 |
| GNo:G0186155 | ||
American Thoracic society Annual Meeting 19-24 MAY 2006$2,400
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,400 | 2006 | 2006 |
| GNo:G0186471 | ||
American Thoracic Society conference$2,000
Funding Body: Ian Potter Foundation
| Project Team | ||
|---|---|---|
| Associate Professor Jodie Simpson | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,000 | 2006 | 2006 |
| GNo:G0186176 | ||
Edit
Research Supervision
| Number of current supervisions | 3 |
|---|---|
| Total current UoN PhD EFTSL | 0.6 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2009 | 2013 | PhD (Medicine) | Co-Supervisor | Epigenetic Regulation of Airway Inflammation in Non-Eosinophilic Asthma |
| 2008 | 2012 | PhD (Medicine) | Co-Supervisor | In Vitro Response of Bronchial Epithelial Cells and Neutrophils to Inflammatory Stimuli: a Comparison of Patients with COPD, healthy Smokers and Healthy Non-Smokers |
| 2007 | 2012 | PhD (Medicine) | Co-Supervisor | In vitro response of bronchial epithelial cells and activiation of lymphocytes to infection with rhinovirus |
Past Supervision
| Year | Program | Supervisor Type | Research Title |
|---|---|---|---|
| 2012 | PhD (Immunology & Microbiol) | Co-Supervisor | Modulation of Responses in Allergic Airways Disease by Haemophilus Influenzae Infection |
Edit
Associate Professor Jodie Simpson
| Work Phone | (02) 40420148 |
|---|---|
| Fax | (02) 4985 5850 |
| Jodie.Simpson@newcastle.edu.au | |
| Position | Senior Research Fellow School of Medicine and Public Health Faculty of Health and Medicine |
| Office | HMRI Level 2 Room 2101, HMRI, John Hunter Hospital |
| URL: | www.newcastle.edu.au/profile/jodie-simpson |
