Dr Ming Yang

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Career Summary

Biography

Dr. Yang graduated from The John Curtin School of Medical Research, Institute of Advanced Studies, Australian National University, with distinction: he was awarded the prestigious Frank Fenner Medal for the  most  outstanding  PhD  dissertation.  Subsequently he was awarded  a prestigious University of Newcastle Research Fellowship and was promoted to level B within the first year after graduation.  Based on his research directions and productivity, he was awarded an NHMRC New Investigator grant. In 2012, he was promoted to Senior Research Fellow. He is now internationally known for his investigations into the pathogenesis of asthma, and the molecular and cellular regulation of inflammation.

Dr. Yang’s group has received international recognition through publication in leading biomedical science journals and has contributed to more than 30 refereed manuscripts in high impact journals (J Exp Med, J Clin Invest, Gastroenterology, J Allergy Clin Immunology, PNAS, J Immunology) with more than 1500 combined citations. He has been successful in obtaining research grants both independently and in collaboration with other investigators (over $3.8 Million). 

Research Directions and Significant Achievements:

In recent years Dr. Yang has initiated investigations into the mechanisms that regulate steroid resistant inflammatory pathways in the lung, to help understand how steroid resistance may develop in asthma. Understanding the mechanisms that regulate steroid-resistant inflammation is important and developing novel non- steroidal therapeutic approaches to the disease will be highly beneficial, as these patients suffer greater morbidity and mortality. Currently, there is no effective treatment and there is very limited functional evidence of the way in which the inflammatory pathways are activated in these patients. Building on clinical studies, we have recently demonstrated, for the first time, that macrophages are crucial in regulating steroid-resistant inflammatory signals. Two papers have been published in the Journal of Immunology and their significance has been recognised by the American Academy of Asthma Allergy and Immunology (symposium invitation, 2010) and the invitation to write two reviews for Current Drug Targets and Journal of Leukocyte Biology.

The unique complexity of respiratory system has limited the development of therapeutic agents that show clinical benefit for severe asthmatic patients. However, the more efficient therapeutics may be developed by silencing the dominant proinflammatory genes, which are responsible for the propagation of the disease. Employing small ‘non-coding’ RNA molecules called microRNAs (miRNA), small interfering RNAs (siRNA) or synthetic analogues of these molecules, ‘antagomirs’, to specifically silence aberrant gene function is of growing interest. Dr. Yang was at the forefront of the first application of RNA interference to modulate AHR and macrophage function in the lung (2006, J Immunology). His works in this field has been recognised by invitations to write reviews for Drug Discovery Today, Pharmacology & Therapeutics and American Journal of Respiratory Cellular and Molecular Biology. Recently, he has been investigating the central roles of miRNA in the regulation of the pro-inflammatory effects of macrophages and thus potential innate immune mediated AHR. Dr. Yang also has extensive research interests in characterizing the pivotal roles of these small non-coding RNAs in modulating the differentiation and function of granulocytes and other immune cells.

Research Expertise
- Immunology - Pharmacology - Pharmaceutical Sciences

Collaborations
Dr. Yang has productive collaborations within Australia and oversea internationally renowned groups. He has extensive academic, intellectual and procedural input into these collaborations and has also contributed significant experimental expertise. These collaborations will continue for the foreseeable future.


Qualifications

  • PhD, Australian National University

Keywords

  • Gene Regulation
  • Haematopoiesis
  • Immunology
  • Infectious Disease
  • Inflammation Inhibition
  • Intracellular Signalling Transduction
  • Pharmaceutical Sciences
  • Pharmacology
  • Respiratory Disease

Fields of Research

CodeDescriptionPercentage
110299Cardiorespiratory Medicine and Haematology not elsewhere classified80
110399Clinical Sciences not elsewhere classified20

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2015 - Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (30 outputs)

YearCitationAltmetricsLink
2014Yang M, Eyers F, Xiang Y, Guo M, Young IG, Rosenberg HF, Foster PS, 'Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs', PLoS ONE, 9 (2014) [C1]

Background: MicroRNAs (miRNAs) are small non-coding RNAs that regulate complex transcriptional networks underpin immune responses. However, little is known about the specific miRN... [more]

Background: MicroRNAs (miRNAs) are small non-coding RNAs that regulate complex transcriptional networks underpin immune responses. However, little is known about the specific miRNA networks that control differentiation of specific leukocyte subsets. In this study, we profiled miRNA expression during differentiation of eosinophils from bone marrow (BM) progenitors (bmEos), and correlated expression with potential mRNA targets involved in crucial regulatory functions. Profiling was performed on whole BM cultures to document the dynamic changes in miRNA expression in the BM microenvironment over the differentiation period. miRNA for network analysis were identified in BM cultures enriched in differentiating eosinophils, and chosen for their potential ability to target mRNA of factors that are known to play critical roles in eosinophil differentiation pathways or cell identify. Methodology/Principal Findings: We identified 68 miRNAs with expression patterns that were up- or down- regulated 5-fold or more during bmEos differentiation. By employing TargetScan and MeSH databases, we identified 348 transcripts involved in 30 canonical pathways as potentially regulated by these miRNAs. Furthermore, by applying miRanda and Ingenuity Pathways Analysis (IPA), we identified 13 specific miRNAs that are temporally associated with the expression of IL-5Ra and CCR3 and 14 miRNAs associated with the transcription factors GATA-1/2, PU.1 and C/EBPe. We have also identified 17 miRNAs that may regulate the expression of TLRs 4 and 13 during eosinophil differentiation, although we could identify no miRNAs targeting the prominent secretory effector, eosinophil major basic protein. Conclusions/Significance: This is the first study to map changes in miRNA expression in whole BM cultures during the differentiation of eosinophils, and to predict functional links between miRNAs and their target mRNAs for the regulation of eosinophilopoiesis. Our findings provide an important resource that will promote the platform for further understanding of the role of these non-coding RNAs in the regulation of eosinophil differentiation and function. © 2014 Yang et al.

DOI10.1371/journal.pone.0097537
CitationsScopus - 2Web of Science - 2
Co-authorsPaul Foster
2014Xiang Y, Eyers F, Young IG, Rosenberg HF, Foster PS, Yang M, 'Identification of MicroRNAs regulating the developmental pathways of bone marrow derived mast cells', PLoS ONE, 9 (2014) [C1]

Background: MicroRNAs (miRNAs) play important roles in leukocyte differentiation, although those utilised for specific programs and key functions remain incompletely characterised... [more]

Background: MicroRNAs (miRNAs) play important roles in leukocyte differentiation, although those utilised for specific programs and key functions remain incompletely characterised. As a global approach to gain insights into the potential regulatory role of miRNA in mast cell differentiation we characterised expression in BM cultures from the initiation of differentiation. In cultures enriched in differentiating mast cells we characterised miRNA expression and identified miRNA targeting the mRNA of putative factors involved in differentiation pathways and cellular identity. Detailed pathway analysis identified a unique miRNA network that is intimately linked to the mast cell differentiation program. Methodology/Principal Findings: We identified 86 unique miRNAs with expression patterns that were up- or down-regulated at 5-fold or more during bone marrow derived mast cells (BMMC) development. By employing TargetScan and MeSH databases, we identified 524 transcripts involved in 30 canonical pathways as potentially regulated by these specific 86 miRNAs. Furthermore, by applying miRanda and IPA analyses, we predict that 7 specific miRNAs of this group are directly associated with the expression of c-Kit and FceRIa and likewise, that 18 miRNAs promote expression of Mitf, GATA1 and c/EBPa three core transcription factors that direct mast cell differentiation. Furthermore, we have identified 11 miRNAs that may regulate the expression of STATs-3, -5a/b, GATA2 and GATA3 during differentiation, along with 13 miRNAs that target transcripts encoding Ndst2, mMCP4 and mMCP6 and thus may regulate biosynthesis of mast cell secretory mediators. Conclusions/ Significance: This investigation characterises changes in miRNA expression in whole BM cultures during the differentiation of mast cells and predicts functional links between miRNAs and their target mRNAs for the regulation of development. This information provides an important resource for further investigations of the contributions of miRNAs to mast cell differentiation and function. © 2014 Xiang et al.

DOI10.1371/journal.pone.0098139
CitationsScopus - 5Web of Science - 4
Co-authorsPaul Foster
2014Li J, Yang M, Li P, Su Z, Gao P, Zhang J, 'Idiopathic pulmonary fibrosis will increase the risk of lung cancer', CHINESE MEDICAL JOURNAL, 127 3142-3149 (2014) [C1]
DOI10.3760/cma.j.issn.0366-6999.20141346Author URL
CitationsScopus - 1Web of Science - 1
2013Eftekhari P, Hajizadeh S, Reza Raoufy M, Reza Masjedi M, Yang M, Hansbro N, et al., 'Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma', EXCLI Journal, 12 184-192 (2013) [C1]

Oxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acety... [more]

Oxidative stress appears to have an important role in glucocorticoid insensitivity, as a crucial problem in asthma therapy. We studied the preventive effect of antioxidant N-acetylcysteine (NAC) on the airway hyper-responsiveness (AHR) and the accumulation of inflammatory cells in the airways in an animal model of steroid resistant acute exacerbation of asthma. Systemically sensitized Balb/C mice were exposed to Ovalbumin aerosol on days 13, 14, 15 and 16, followed by intratracheal lipopolysaccharide (LPS) to induce acute exacerbation. NAC (intraperitoneal, 320 mg/kg 30 min before and 12 hours after each challenge) reduced hyperresponsiveness with/out dexamethasone. LPS application caused neutrophilia in bronchoalveolar lavage fluid (BALF) and eosinophil count was higher than respective control in BALF as well as neutrophils after dexamethasone treatment. NAC significantly decreased neutrophil and eosinophil count in BALF as well as inflammatory cytokines (IL-13 and IL-5).We concluded that addition of NAC to asthma therapy has beneficial preventive effects in an animal model of steroid resistant acute exacerbation of asthma.

CitationsScopus - 1Web of Science - 1
Co-authorsNicole Hansbro, Paul Foster
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
CitationsScopus - 29Web of Science - 30
Co-authorsPeter Wark, Jay Horvat, Paul Foster, Philip Hansbro, Nicole Hansbro, Simon Keely
2013Foster PS, Plank MW, Collison AM, Tay HL, Kaiko GE, Li J, et al., 'The emerging role of microRNAs in regulating immune and inflammatory responses in the lung', Immunological Reviews, 253 198-215 (2013) [C1]
CitationsScopus - 8Web of Science - 11
Co-authorsPaul Foster, Joerg Mattes, Philip Hansbro
2013Hansbro PM, Scott GV, Essilfie A-T, Kim RY, Starkey MR, Nguyen D, et al., 'Th2 cytokine antagonists: Potential treatments for severe asthma', Expert Opinion on Investigational Drugs, 22 49-69 (2013) [C1]
CitationsScopus - 18Web of Science - 13
Co-authorsPhilip Hansbro, Malcolm Starkey, Paul Foster, Jay Horvat
2013Li JJ, Tay HL, Plank M, Essilfie A-T, Hansbro PM, Foster PS, Yang M, 'Activation of Olfactory Receptors on Mouse Pulmonary Macrophages Promotes Monocyte Chemotactic Protein-1 Production', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0080148Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsPhilip Hansbro, Paul Foster
2012Yang M, Kumar RK, Hansbro PM, Foster PS, 'Emerging roles of pulmonary macrophages in driving the development of severe asthma', Journal of Leukocyte Biology, 91 557-569 (2012) [C1]
CitationsScopus - 19Web of Science - 18
Co-authorsPhilip Hansbro, Paul Foster
2012Kumar RK, Yang M, Herbert C, Foster PS, 'Interferon-¿, pulmonary macrophages and airway responsiveness in asthma', Inflammation and Allergy - Drug Targets, 11 292-297 (2012) [C1]
CitationsScopus - 6
Co-authorsPaul Foster
2011Wang W, Hansbro PM, Foster PS, Yang M, 'An alternate STAT6-independent pathway promotes eosinophil influx into blood during allergic airway inflammation', PLoS ONE, 6 e17766 (2011) [C1]
DOI10.1371/journal.pone.0017766
CitationsScopus - 7Web of Science - 6
Co-authorsPaul Foster, Philip Hansbro
2010Li J, Wang W, Baines KJ, Bowden NA, Hansbro PM, Gibson PG, et al., 'IL-27/IFN-y induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages', Journal of Immunology, 185 4401-4409 (2010) [C1]
DOI10.4049/jimmunol.1001039
CitationsScopus - 35Web of Science - 32
Co-authorsPaul Foster, Philip Hansbro, Peter Gibson, Nikola Bowden, Katherine Baines
2010Yang M, Kumar RK, Foster PS, 'Interferon-Y and pulmonary macrophages contribute to the mechanisms underlying prolonged airway hyperresponsiveness', Clinical and Experimental Allergy, 40 163-173 (2010) [C1]
DOI10.1111/j.1365-2222.2009.03393.x
CitationsScopus - 16Web of Science - 12
Co-authorsPaul Foster
2010Hardy CL, Lemasurier JS, Olsson F, Dang T, Yao J, Yang M, et al., 'Interleukin-13 regulates secretion of the tumor growth factor-beta superfamily cytokine activin A in allergic airway inflammation', American Journal of Respiratory Cell and Molecular Biology, 42 667-675 (2010) [C1]
DOI10.1165/rcmb.2008-0429OC
CitationsScopus - 12Web of Science - 11
2010Wang W, Li J, Foster PS, Hansbro PM, Yang M, 'Potential therapeutic targets for steroid-resistant asthma', Current Drug Targets, 11 957-970 (2010) [C1]
DOI10.2174/138945010791591412
CitationsScopus - 25Web of Science - 24
Co-authorsPhilip Hansbro, Paul Foster
2009Yang M, Kumar RK, Foster PS, 'Pathogenesis of steroid-resistant airway hyperresponsiveness: Interaction between IFN-gamma and TLR4/MyD88 pathways', Journal of Immunology, 182 5107-5115 (2009) [C1]
DOI10.4049/jimmunol.0803468
CitationsScopus - 38Web of Science - 30
Co-authorsPaul Foster
2008Yang M, Mattes J, 'Discovery, biology and therapeutic potential of RNA interference, microRNA and antagomirs', Pharmacology & Therapeutics, 117 94-104 (2008) [C1]
DOI10.1016/j.pharmthera.2007.08.004
CitationsScopus - 59Web of Science - 51
Co-authorsJoerg Mattes
2007Mattes J, Yang M, Foster PS, 'Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function?', American Journal of Respiratory and Cellular Molecular Biology, 36 8-12 (2007) [C1]
DOI10.1165/rcmb.2006-0227TR
CitationsScopus - 43Web of Science - 38
Co-authorsPaul Foster, Joerg Mattes
2007Webb DC, Yang M, Matthaei (Ext) K, Foster PS, 'Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function', Journal of Immunology, 178 219-227 (2007) [C1]
CitationsScopus - 43Web of Science - 42
Co-authorsPaul Foster
2006Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmmermann N, Mahalingam S, et al., 'Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness', Journal of Immunology, 177 5595-5603 (2006) [C1]
DOI10.4049/jimmunol.177.8.5595
CitationsScopus - 69Web of Science - 61
Co-authorsPaul Foster
2006Yang M, Rangasamy D, Matthaei K, Frew A, Zimmmermann N, Mahalingham S, et al., 'Inhibition of arginase I activity by RNA interference attenuates interleukin-13 induced airways hyperresponsiveness', ACTA PHARMACOLOGICA SINICA, 27 266-266 (2006)
Author URL
Co-authorsPaul Foster
2006Yang M, Mattes J, Hansbro PM, Foster PS, 'Employment of microRNA profiles and RNA interference and antagomirs for the characterization and treatment of respiratory disease', Drug Discovery Today: Therapeutic Strategies, 3 325-332 (2006) [C1]
DOI10.1016/j.ddstr.2006.10.001
CitationsScopus - 4
Co-authorsJoerg Mattes, Paul Foster, Philip Hansbro
2006Siegle JS, Hansbro NG, Herbert C, Yang M, Foster PS, Kumar RK, 'Airway hyperreactivity in exacerbation of chronic asthma is independent of elosinophilic inflammation', American Journal of Respiratory Cell and Molecular Biology, 35 565-570 (2006) [C1]
DOI10.1165/rcmb.2006-0135OC
CitationsScopus - 42Web of Science - 39
Co-authorsNicole Hansbro, Paul Foster
2004Forbes E, Smart V, D'Aprile A, Henry P, Yang M, Matthaei KI, et al., 'T Helper-2 Immunity Regulates Bronchial Hyperresponsiveness in Eosinophil-Associated Gastrointestinal Disease in Mice', Gastroenterology, 127 105-118 (2004) [C1]
DOI10.1053/j.gastro.2004.03.057
CitationsWeb of Science - 13
Co-authorsPaul Foster
2004Forbes E, Murase T, Yang M, Matthaei KI, Lee JJ, Lee NA, et al., 'Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase1', J Immunol, 172 5664-5675 (2004) [C1]
CitationsScopus - 81Web of Science - 71
Co-authorsPaul Foster
2004Fulkerson PC, Zimmermann N, Brandt EB, Muntel EE, Doepker MP, Kavanaugh JL, et al., 'Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by INF-g (Mig, CXCL9)', Proceedings of the National Academy of Sciences of the USA, 101 1987-1992 (2004) [C1]
DOI10.1073/pnas.0308544100
CitationsScopus - 71Web of Science - 67
Co-authorsPaul Foster
2003Zimmerman N, King NE, Laporte J, Yang M, Mishra A, Pope S, et al., 'Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis', Journal of Clinical Investigation, 111 1863-1874 (2003) [C1]
DOI10.1172/JCI200317912
CitationsScopus - 371Web of Science - 345
Co-authorsPaul Foster
2003Kumar RK, Herbert C, Thomas PS, Wollin L, Beume R, Yang M, et al., 'Inhibition of inflammation and remodeling by roflumilast and dexamethasone in murine chronic asthma', Journal of Pharmacology and Experimental Therapeutics, 307 349-355 (2003) [C1]
DOI10.1124/jpet.103.053819
CitationsScopus - 107Web of Science - 86
Co-authorsPaul Foster
2003Yang M, Hogan SP, Mahalingam S, Pope SM, Zimmerman N, Fulkerson P, et al., 'Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity', Journal of Allergy and Clinical Immunology, 112 935-943 (2003) [C1]
DOI10.1016/j.jaci.2003.08.010
CitationsScopus - 71
Co-authorsPaul Foster
2003Foster PS, Webb DC, Yang M, Herbert C, Kumar RK, 'Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma', Clinical and Experimental Allergy, 33 688-695 (2003) [C1]
DOI10.1046/j.1365-2222.2003.01647.x
CitationsScopus - 42Web of Science - 36
Co-authorsPaul Foster
Show 27 more journal articles

Conference (3 outputs)

YearCitationAltmetricsLink
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
Author URL
Co-authorsPhilip Hansbro, Nicole Hansbro, Simon Keely, Paul Foster, Peter Wark, Jay Horvat
2012Li J, Foster PS, Yang M, 'Inducible microRNA-X expression underpins steroid- resistant airway hyperresponsiveness by upregulating IL-27 expression', Respirology, Canberra, ACT (2012) [E3]
Co-authorsPaul Foster
2008Yang M, Ma C, Foster PS, 'Antigen-specific TH1 cells induce airway hyper-reactivity in co-operation with lipopolysaccharide in BALB/C mice', Respirology, Melbourne, VIC (2008) [E3]
DOI10.1111/j.1440-1843.2008.01252.x
Co-authorsPaul Foster
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Grants and Funding

Summary

Number of grants19
Total funding$4,569,323

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $2,000

9th Biennial Symposium of the International Esoinophil Society, Chicago USA, 14-18 July 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Ming Yang
SchemeTravel Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500734
Type Of FundingInternal
CategoryINTE
UONY

20141 grants / $677,562

New way of treating respiratory infections and airway inflammatory diseases by targeting miRNA $677,562

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Ming Yang
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300121
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20131 grants / $20,000

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201186
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20122 grants / $564,551

Understanding the mechanisms of steroid resistant inflammatory pathways in mouse models of asthma: potential new treatment approaches$514,551

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Ming Yang
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100099
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100975
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20113 grants / $429,250

Targeting pro-survival mechanisms to sensitize human melanoma to immunotherapy$359,250

Funding body: Cancer Council NSW

Funding bodyCancer Council NSW
Project TeamProfessor Xu Dong Zhang, Doctor Ming Yang
SchemeResearch Program
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000379
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Targeting Pro-Survival Mechanisms to Sensitize Human Melanoma to Immunotherapy$25,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Xu Dong Zhang, Doctor Ming Yang
SchemeNear Miss Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1001046
Type Of FundingInternal
CategoryINTE
UONY

20102 grants / $40,509

Buxco FinePointe software and FinePointe RC system for mice $39,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Nicole Hansbro, Doctor Simon Phipps, Doctor Ming Yang, Doctor Kelly Asquith, Doctor Catherine Ptaschinski, Professor Rakesh Kumar, Professor Judith Black
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000053
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

40th Annual Scientific Meting for Australiasian Society for Immunology 2010, Perth, 5 - 9 December 2010$1,509

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Ming Yang
SchemeTravel Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1001004
Type Of FundingInternal
CategoryINTE
UONY

20091 grants / $41,150

Coulter counter$41,150

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189851
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20084 grants / $564,200

Innate immune factors regulate steroid-resistant airways hyperreactivity and asthma$503,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Ming Yang
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187617
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Individually ventilated cages (IVC) and associated ventilator, holding boxes and water bottles$35,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Simon Phipps, Doctor Ming Yang, Doctor Nicole Hansbro, Doctor Kelly Asquith
SchemeEquipment Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188541
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

MicroRNA and antagomirs in the regulation and suppression of interferon (IFN)-g and lipopolysaccharide (LPS) induced steroid-resistant airways hyperreactivity$24,250

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Ming Yang, Laureate Professor Paul Foster
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188474
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Melbourne Australia, 30/3/2008 - 2/4/2008$1,700

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Ming Yang
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188618
Type Of FundingInternal
CategoryINTE
UONY

20061 grants / $1,500

15th World Congress of pharmacology july 2-7, 2006$1,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Ming Yang
SchemeTravel Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186492
Type Of FundingInternal
CategoryINTE
UONY

20053 grants / $2,228,601

Drug targets from new animal models$2,030,948

Funding body: CRC for Asthma

Funding bodyCRC for Asthma
Project TeamLaureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Ming Yang, Dr Simon Phipps
SchemeResearch Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0185860
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

Understanding the role of IL-13 in the pathogenesis of asthma$168,173

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Ming Yang
SchemePostdoctoral Research Fellowship
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184063
Type Of FundingInternal
CategoryINTE
UONY

Investigating the role of IL-13 induced arginas I activity in the development of allergic lung disease$29,480

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamDoctor Ming Yang
SchemeMajor Equipment Award
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185636
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2012Roles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation
Microbiology, Faculty of Health and Medicine
Principal Supervisor
2012Understanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
Microbiology, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014Respiratory Innate Immune Factors Regulate Steroid-resistant Airway Hyperreactivity and Asthma
Microbiology, Faculty of Health and Medicine
Principal Supervisor
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Dr Ming Yang

Position

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Emailming.yang@newcastle.edu.au
Phone(02) 40420183

Office

RoomLevel 2, Immunology & Microbiology
BuildingHMRI Building
LocationHMRI Building

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