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Dr Hayley Scott

Conjoint Fellow

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

Dr Scott is a Postdoctoral Research Fellow in the Priority Research Centre for Healthy Lungs. Her research examines the impact of obesity, exercise and nutrition in promoting or impeding inflammation and, ultimately, the effect this has on the pathogenesis of respiratory diseases. Dr Scott recently returned from The University of Queensland, where she completed a two year Postdoctoral Fellowship examining how exercise intensity impacts the inflammatory responses of adults with asthma.

A primary research goal of Dr Scott's is to conduct high quality research that is directly translatable into clinical practice. Her dietetic qualification position her uniquely to both devise and conduct this style of research. As an example, Dr Scott developed and tested a weight loss program tailored to obese adults with asthma, which found that a weight loss of 5-10% is associated with clinically important improvements in asthma control and asthma-related quality of life in 58% and 83% of patients respectively. Her weight loss recommendations have since been implemented into clinical practice guidelines published by the National Asthma Council Australia, with brochures distributed to health care providers and patients nationally. Dr Scott also developed a weight loss program and performed dietetic counselling in adults with chronic obstructive pulmonary disease (COPD) and, coupled with an exercise program, resulted in weight loss that coincided with highly significant improvements to health outcomes associated with mortality. She has also counselled patients with asthma to modify their dietary intake of antioxidants, which impacted their risk of experiencing an asthma exacerbation.

Dr Scott enjoys conducting cutting edge research. She was the first internationally to demonstrate an inflammatory mechanism driving the association between obesity and asthma, and this work has since been replicated by other research groups. As a continuation of this work, her weight loss program demonstrated that loss of fat tissue within the gynoid (hip) region is associated with a reduction to airway inflammation in females, while in males a reduced dietary intake of saturated fat is associated with a reduction to airway inflammation. This suggests that these changes are operating via different mechanisms in males versus females and, importantly, suggests dietetic intervention has beneficial effects for those with asthma.

Dr Scott's work demonstrates that exercise can be used as an adjuvant asthma therapy. She has shown that a 10-week exercise training program results in a highly significant 5-fold reduction in airway inflammation and improvements in asthma-related quality of life. She is currently investigating the impact of moderate-intensity and vigorous-intensity exercise on asthma, to establish which provides the greatest benefit for asthma outcomes. This research will provide vital evidence to help inform asthma management guidelines. An emerging theme, Dr Scott is also examining the impact of sex hormones on asthma. She has shown that asthmatic women using the oral contraceptive pill (OCP) have better asthma control and less inflamed airways when compared with those not using the OCP.

Research Expertise
Dr Scott completed a Bachelor Nutrition & Dietetics with Honours in 2006, worked as a Research Assistant, then completed a PhD in 2012. Her dietetic qualification and experience enables her to conduct specialised nutrition research. This has included the development and implementation of two highly successful weight loss programs. Dr Scott has worked clinically with respiratory research patients for more than 8 years and can perform a number of specialised techniques including sputum collection for the measurement of airway inflammation and dual-energy x-ray absorptiometry (DEXA) for the measurement of body composition and bone density. Dr Scott also has laboratory experience processing both blood and sputum samples, and performing ELISA's. Her work utilises specialised laboratory techniques including GC and HPLC for the measurement of fatty acids and antioxidants. as well as gene expression in blood and sputum samples.

Community Engagement and Peer Review
Dr Scott believes in pursuing opportunities that enable her to give back to the scientific community. From 2012-2014 she was Chair of the Nutrition Society of Australia (Newcastle Branch) and a National Committee Member. These roles required her to organise scientific meetings in the Newcastle region and provide input into the governance of the society at a national level. Since this time she has remained a Committee Member of her local group, both in Brisbane and upon her return to Newcastle. She has had media exposure including radio and newspaper interviews. Dr Scott was a contributing author for the most recent edition of "Better Living with COPD: A Patient Guide". She has acted as a reviewer for theses, NHMRC project grants, and is a regular reviewer (1-4/month) for top international journals including Thorax and European Respiratory Journal.


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Nutrition and Dietetics (Honours), University of Newcastle

Keywords

  • Asthma
  • Fatty acids
  • Inflammation
  • Nutrition
  • Obesity
  • Respiratory Disease

Fields of Research

Code Description Percentage
110199 Medical Biochemistry and Metabolomics not elsewhere classified 50
110203 Respiratory Diseases 50
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2013 Scott H, Wood LG, Garg ML, Gibson PG, 'Asthma and Inflammation', Nutrition and Physical activity in inflammatory diseases, CABI, Oxford, UK 299-321 (2013) [B1]
Co-authors Peter Gibson, Manohar Garg, Lisa Wood

Journal article (17 outputs)

Year Citation Altmetrics Link
2016 Scott HA, Gibson PG, Garg ML, Upham JW, Wood LG, 'Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype', Allergy: European Journal of Allergy and Clinical Immunology, 71 1037-1047 (2016) [C1]

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Background Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese-ast... [more]

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Background Both systemic inflammation and sex hormones have been proposed as potential mediators of the obese-asthma phenotype. The aim of this study was to examine the associations between sex hormones, oral contraceptive pill (OCP) use, systemic inflammation and airway inflammation in adults with asthma. Methods Obese (n = 39) and nonobese (n = 42) females and obese (n = 24) and nonobese (n = 25) males with asthma were recruited. Females were further categorized as reproductive-aged (<50 years old; n = 36) or older (>50 years old; n = 45). Thirteen (36.1%) reproductive-aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers. Results Obese reproductive-aged females had higher sputum %neutrophils than nonobese reproductive-aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C-reactive protein and IL-6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive-aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015). Conclusions This study suggests that sex hormones and systemic inflammation may be mediating the obese-asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive-aged females warrants further investigation.

DOI 10.1111/all.12891
Citations Scopus - 2Web of Science - 2
Co-authors Manohar Garg, Peter Gibson, Lisa Wood
2016 Ballantyne D, Scott H, MacDonald-Wicks L, Gibson PG, Wood LG, 'Resistin is a predictor of asthma risk and resistin:adiponectin ratio is a negative predictor of lung function in asthma', Clinical and Experimental Allergy, 46 1056-1065 (2016) [C1]

© 2016 John Wiley & Sons LtdBackground: Adipokines, such as resistin and adiponectin, modify inflammation and may contribute to increased asthma risk and severity in obese people... [more]

© 2016 John Wiley & Sons LtdBackground: Adipokines, such as resistin and adiponectin, modify inflammation and may contribute to increased asthma risk and severity in obese people. Objective: To examine plasma resistin and resistin:adiponectin ratio (i) in asthmatics compared to healthy controls, (ii) according to asthma severity, obesity and gender (iii) following weight loss in obese asthmatics. Methods: In a cross-sectional observational study of asthmatic adults (n = 96) and healthy controls (n = 46), plasma resistin and adiponectin were measured. In a separate intervention study, obese asthmatic adults (n = 27) completed a 10-week weight loss intervention and plasma resistin and adiponectin concentrations were analysed. Results: Plasma resistin and resistin:adiponectin ratio were higher in asthma compared to controls and were higher again in subjects with a severe vs. mild-to-moderate asthma pattern. Amongst asthmatic subjects, resistin was not modified by gender or obesity, while adiponectin was lower in males and obese subjects. As a result, resistin:adiponectin ratio was higher in obese males, non-obese males and obese females, compared to non-obese females. In a logistic regression model, plasma resistin concentration was a predictor of asthma risk. In a multiple linear regression model, plasma resistin:adiponectin ratio was a negative predictor of FEV1 in asthma. Following weight loss, neither resistin, adiponectin nor resistin:adiponectin ratio was changed. However, the change (¿) in %body fat was associated with ¿ resistin:adiponectin ratio. Post-intervention ¿ resistin was negatively correlated with both ¿FRC and ¿RV. Conclusion and clinical relevance: This study demonstrates that resistin and resistin:adiponectin ratio are higher in asthma and are higher again in subjects who have more severe disease. Resistin:adiponectin ratio is highest in obese male asthmatics. As resistin is a predictor of asthma risk and resistin:adiponectin is a predictor of FEV1 in asthma, these adipokines may be contributing to the obese asthma phenotype, thus providing a potential therapeutic target for obese asthma.

DOI 10.1111/cea.12742
Citations Scopus - 1
Co-authors Lisa Wood, Peter Gibson, Lesley Wicks
2016 McDonald VM, Gibson PG, Scott HA, Baines PJ, Hensley MJ, Pretto JJ, Wood LG, 'Should we treat obesity in COPD? The effects of diet and resistance exercise training.', Respirology, 21 875-882 (2016)
DOI 10.1111/resp.12746
Citations Scopus - 2Web of Science - 2
Co-authors Michael Hensley, Peter Gibson, Vanessa Mcdonald, Lisa Wood
2016 Scott HA, Wood LG, Gibson PG, 'What About Neutrophils in Obese Asthma?', AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 55 462-462 (2016)
Co-authors Peter Gibson, Lisa Wood
2015 Periyalil HA, Wood LG, Scott HA, Jensen ME, Gibson PG, 'Macrophage activation, age and sex effects of immunometabolism in obese asthma', European Respiratory Journal, 45 388-395 (2015) [C1]

Copyright © ERS 2015.Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex... [more]

Copyright © ERS 2015.Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometabolism in obese asthma. Obese and non-obese asthmatic children and adults underwent spirometry, body composition assessment by dual energy X-ray absorptiometry and measurement of serum soluble CD163 (sCD163), tryptase, C-reactive protein (CRP) and other adipocytokines. Plasma CRP (p<0.01) and leptin (p<0.01) were elevated in obese asthmatic adults, and sCD163 (p=0.003) was elevated in obese asthmatic children. We observed significantly higher sCD163 in obese female children compared to obese female adults and male children, and higher CRP in obese female adults compared to obese male children and adults. Serum tryptase concentrations were not significantly different across age groups. sCD163 positively correlated with the proportion of android fat in obese female children (r=0.70, p=0.003) and obese female adults (r=0.65, p=0.003). In obese female children, sCD163 was inversely associated with forced expiratory volume in 1 s % predicted (r=-0.55, p=0.02) and was positively associated with the Asthma Control Questionnaire (r=0.57, p=0.02). Obese children with asthma have sex-specific macrophage activation, which may contribute to worse asthma control and lung function. The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level.

DOI 10.1183/09031936.00080514
Citations Scopus - 4Web of Science - 3
Co-authors Peter Gibson, Lisa Wood
2015 Scott HA, Latham JR, Callister R, Pretto JJ, Baines K, Saltos N, et al., 'Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma', Annals of Allergy, Asthma and Immunology, 114 470-479 (2015) [C1]

© 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.Background Although exercise has multiple health benefits, relatively litt... [more]

© 2015 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.Background Although exercise has multiple health benefits, relatively little attention has been paid to its potential therapeutic effects in those with asthma. Objective To examine the effects of acute exercise on inflammation in physically inactive and active adults with asthma. Methods Fourteen adults with asthma (n = 6 physically inactive, n = 8 physically active) completed (1) 30 minutes of moderate-intensity exercise on a treadmill and (2) 30 minutes of rest in random order, with 4 weeks between sessions. Exhaled nitric oxide (eNO) was measured before and after the intervention (0, 0.5, 1, 2, 4, and 24 hours). Blood inflammatory mediators were measured before and after the intervention (0, 2, and 24 hours). Results Physically inactive participants had a significant decrease in eNO 4 hours after exercise (-4.8 ppb, -6.4 to -0.5 ppb, P =.028), which was not observed in physically active participants (P =.362). Interluekin-1 receptor antagonist increased in the physically inactive group 2 hours after exercise, with this increase strongly correlated with the decrease in eNO at 4 hours (R = -0.685, P =.007) and 24 hours (R = -0.659, P =.014) after exercise. Interleukin-6 was increased significantly 2 hours after exercise in physically inactive participants. Blood neutrophils and nuclear factor erythroid 2-like 2 gene expression were increased 2 hours after exercise in the overall cohort. Conclusion This study demonstrates that acute moderate-intensity exercise is associated with decreased eNO in physically inactive adults with asthma and suggests that interluekin-1 receptor antagonist could have a role in mediating this effect. The attenuated response in physically active participants might be due to the sustained anti-inflammatory effects of exercise training. Future studies should investigate the impact of exercise intensity and exercise training on airway inflammation in those with asthma.

DOI 10.1016/j.anai.2015.04.002
Citations Scopus - 3Web of Science - 3
Co-authors Robin Callister, Lisa Wood, Katherine Baines
2015 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Determinants of weight loss success utilizing a meal replacement plan and/or exercise, in overweight and obese adults with asthma', Respirology, 20 243-250 (2015) [C1]

© 2014 Asian Pacific Society of Respirology.Background and objective While weight loss has been shown to reduce obesity-related comorbidity, many weight loss treatments fail. Fac... [more]

© 2014 Asian Pacific Society of Respirology.Background and objective While weight loss has been shown to reduce obesity-related comorbidity, many weight loss treatments fail. Factors that enhance weight loss success are unknown, particularly in those with asthma. The aim of the study was to identify patient characteristics that predict weight loss success in adults with asthma. Methods Baseline and change in asthma characteristics and eating behaviours were investigated for relationships with weight loss and fat loss using multiple linear regression, in 38 overweight and obese adults with asthma randomized to dietary, exercise or combined interventions targeting weight loss for 10 weeks. Results Mean ± standard deviation weight loss was 6.6 ± 5.1 kg. Greater %weight loss and %fat loss was achieved in those with poorer asthma-related quality of life at baseline ((rs = 0.398, P = 0.015) and (rs = 0.455, P = 0.005) respectively), with 1.7% greater absolute weight loss at week 10 corresponding to each one unit reduction in the asthma-related quality of life score at baseline. Furthermore, a lower baseline forced expiratory volume in 1 s/forced vital capacity correlated with greater weight loss (rs = 0.398, P = 0.015). Male sex was associated with a 3.6 kg greater weight loss (P = 0.087). Reducing emotional eating during the programme was associated with greater weight loss in women (rs = 0.576, P = 0.010). Conclusions This study demonstrates that individuals with more severe asthma at baseline are more successful in achieving weight loss, which could be a consequence of greater motivation and could be used as a motivational tool within the clinical setting. Gender tailoring of weight loss programmes may be useful to enhance weight loss success. Future studies are urgently needed to establish predictors of long-term weight loss maintenance in those with asthma. See Editorial, page 179 This study is the first to demonstrate that more severe asthma at baseline, male sex, and improvements in eating behaviours during weight loss are associated with greater weight loss success in overweight and obese adults with asthma. Our findings may inform the development of asthma-specific weight management guidelines.

DOI 10.1111/resp.12423
Citations Scopus - 3Web of Science - 3
Co-authors Manohar Garg, Philip Morgan, Robin Callister, Lisa Wood, Peter Gibson
2014 Scott HA, Jensen ME, Wood LG, 'Dietary interventions in asthma', Current Pharmaceutical Design, 20 1003-1010 (2014) [C1]

Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immu... [more]

Asthma is a chronic inflammatory disorder of the airways. The inflammatory response in asthma is heterogeneous. Allergen specific responses lead to activation of the acquired immune system, via a predominantly IL-5 mediated, eosinophilic pathway. Stimuli such as viruses and bacteria activate the innate immune system, via a predominantly IL-8 mediated, neutrophilic pathway. Asthma has also been demonstrated to involve a systemic inflammatory component. Glucocorticoids are the predominant pharmacological treatment used to control inflammation in asthma. However, compliance with medications can be compromised due to patient concerns about side effects. Hence dietary interventions that target the inflammatory response in asthma have great potential. Various aspects of dietary intake are known to modulate inflammation. Saturated fatty acids can induce an inflammatory response via activation of pattern recognition receptors. Omega-3 fatty acids can be anti-inflammatory, via mechanisms such as modification of eicosanoid production. Antioxidants can have anti-inflammatory effects as they scavenge free radicals, preventing activation of transcription factors including NF-¿B. Chronic excess energy intake can lead to obesity, which augments inflammation due to the release of inflammatory mediators by adipose tissue. Here we review the role of these dietary components in asthma. © 2014 Bentham Science Publishers.

DOI 10.2174/13816128113190990421
Citations Scopus - 9Web of Science - 8
Co-authors Lisa Wood
2014 Morgan PJ, Scott HA, Young MD, Plotnikoff RC, Collins CE, Callister R, 'Associations between program outcomes and adherence to Social Cognitive Theory tasks: process evaluation of the SHED-IT community weight loss trial for men', INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY, 11 (2014) [C1]
DOI 10.1186/s12966-014-0089-9
Citations Scopus - 8Web of Science - 7
Co-authors Ron Plotnikoff, Philip Morgan, Myles Young, Robin Callister, Clare Collins
2013 Morgan PJ, Barnett LM, Cliff DP, Okely AD, Scott HA, Cohen KE, Lubans DR, 'Fundamental movement skill interventions in youth: A systematic review and meta-analysis', Pediatrics, 132 (2013) [C1]
DOI 10.1542/peds.2013-1167
Citations Scopus - 46Web of Science - 39
Co-authors David Lubans, Philip Morgan
2013 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial', Clinical and Experimental Allergy, 43 36-49 (2013) [C1]
DOI 10.1111/cea.12004
Citations Scopus - 50Web of Science - 45
Co-authors Manohar Garg, Peter Gibson, Robin Callister, Philip Morgan, Lisa Wood
2012 Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized controlled trial', American Journal of Clinical Nutrition, 96 534-543 (2012) [C1]
Citations Scopus - 46Web of Science - 39
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
2012 Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma', Chest, 142 86-93 (2012) [C1]
Citations Scopus - 92Web of Science - 83
Co-authors Lisa Wood, Peter Gibson, Katherine Baines
2012 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Relationship between body composition, inflammation and lung function in overweight and obese asthma', Respiratory Research, 13 1-10 (2012) [C1]
Citations Scopus - 17Web of Science - 16
Co-authors Robin Callister, Lisa Wood, Manohar Garg, Peter Gibson, Philip Morgan
2011 Scott HA, Gibson PG, Garg ML, Wood LG, 'Airway inflammation is augmented by obesity and fatty acids in asthma', European Respiratory Journal, 38 594-602 (2011) [C1]
Citations Scopus - 87Web of Science - 76
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
2009 Wood LG, Scott HA, Garg ML, Gibson PG, 'Innate immune mechanisms linking non-esterified fatty acids and respiratory disease', Progress in Lipid Research, 48 27-43 (2009) [C1]
DOI 10.1016/j.plipres.2008.10.001
Citations Scopus - 28Web of Science - 24
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
2009 McFarlane J, Scott HA, Robertson VJ, Gleeson C, Vanderkroft D, Wilson K, 'General practitioner and paediatrician self-reported capacity for the diagnosis and management of childhood and adolescent overweight and obesity', Nutrition & Dietetics, 66 176-185 (2009) [C1]
DOI 10.1111/j.1747-0080.2009.01363.x
Show 14 more journal articles

Conference (27 outputs)

Year Citation Altmetrics Link
2015 Scott H, Latham J, Callister R, Pretto J, Saltos N, Upham J, Wood L, 'A SINGLE BOUT OF EXERCISE IS ASSOCIATED WITH A TRANSIENT REDUCTION TO EXHALED NITRIC OXIDE IN PHYSICALLY INACTIVE ADULTS WITH ASTHMA', RESPIROLOGY (2015) [E3]
Co-authors Robin Callister, Lisa Wood
2014 Periyalil H, Scott H, Jensen M, Wood L, Gibson P, 'MACROPHAGE ACTIVATION IS A DETERMINANT OF DEVELOPMENTAL EFFECTS OF IMMUNOMETABOLISM IN OBESE ASTHMA', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_7
Co-authors Lisa Wood, Peter Gibson
2014 Mcdonald V, Gibson P, Scott H, Baines P, Hensley M, Pretto J, Wood L, 'SHOULD WE TREAT OBESITY IN COPD? THE EFFECTS OF WEIGHT LOSS AND RESISTANCE TRAINING IN OBESE COPD', RESPIROLOGY (2014) [E3]
Co-authors Lisa Wood, Vanessa Mcdonald, Peter Gibson, Michael Hensley
2013 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Female Reproductive Stage Drives The Association Between Obesity And Neutrophilic Airway Inflammation In Adults With Asthma', American Journal of Respiratory and Critical Care Medicine (2013) [E3]
Co-authors Manohar Garg, Lisa Wood, Peter Gibson
2013 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'The Association Between Obesity and Asthma is Driven By Female Reproductive Stage', Australasian Medical Journal (2013) [E3]
Co-authors Lisa Wood, Manohar Garg, Peter Gibson
2013 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'REPRODUCTIVE STAGE DRIVES LINK BETWEEN OBESITY AND NEUTROPHILIC AIRWAY INFLAMMATION IN FEMALES WITH ASTHMA', RESPIROLOGY (2013) [E3]
Co-authors Manohar Garg, Lisa Wood, Peter Gibson
2012 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Female reproductive stage drives the association between obesity and neutrophilic airway inflammation in adults with asthma', Abstracts. American Thoracic Society 2012 International Conference (2012) [E3]
Co-authors Lisa Wood, Manohar Garg, Peter Gibson
2012 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Reproductive stage drives link between obesity and neutrophilic airway inflammation in females with asthma', Abstracts. TSANZ Annual Scientific Meeting 2012 (2012) [E3]
Co-authors Manohar Garg, Peter Gibson, Lisa Wood
2012 Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized clinical trial', Respirology (2012) [E3]
Citations Web of Science - 2
Co-authors Manohar Garg, Lisa Wood, Peter Gibson
2012 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Weight loss improves clinical asthma outcomes and airway inflammation in overweight and obese asthmatics', Obesity Research & Clinical Practice (2012) [E3]
Co-authors Lisa Wood, Peter Gibson, Philip Morgan, Robin Callister, Manohar Garg
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'The influence of body composition and inflammation on lung function in asthma', Australasian Medical Journal (2011) [E3]
Co-authors Philip Morgan, Robin Callister, Peter Gibson, Manohar Garg, Lisa Wood
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved after body fat reduction in overweight and obese asthmatics', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Philip Morgan, Robin Callister, Lisa Wood, Manohar Garg, Peter Gibson
2011 Wood LG, Scott HA, Gibson PG, 'Systemic inflammation is increased in neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Peter Gibson, Lisa Wood
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is greatest in subjects with more severe asthma', American Journal of Respiratory and Critical Care Medicine (2011) [E3]
Co-authors Philip Morgan, Peter Gibson, Manohar Garg, Lisa Wood, Robin Callister
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is related to asthma severity', Respirology (2011) [E3]
Co-authors Manohar Garg, Peter Gibson, Lisa Wood, Philip Morgan, Robin Callister
2011 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Body fat reduction improves clinical asthma outcomes in overweight and obese asthma', Respirology (2011) [E3]
Co-authors Philip Morgan, Manohar Garg, Peter Gibson, Robin Callister, Lisa Wood
2011 Wood LG, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated increased systemic inflammation in asthma', Respirology (2011) [E3]
Co-authors Peter Gibson, Lisa Wood
2011 Fu J, Baines KJ, Wood LG, Scott HA, Gibson PG, 'Low-grade systemic inflammation is associated with airway neutrophilia in asthma', Respirology (2011) [E3]
Co-authors Lisa Wood, Katherine Baines, Peter Gibson
2011 Fu J, Baines KJ, Gibson PG, Scott HA, Wood LG, 'Systemic inflammation mediates airway neutrophilia via the regulation of IL-8 receptor mRNA expression', Respirology (2011) [E3]
Co-authors Katherine Baines, Lisa Wood, Peter Gibson
2010 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Fatty acids and obesity differentially affect airway inflammation in males and females with asthma', American Journal of Respiratory and Critical Care Medicine (2010) [E3]
Co-authors Lisa Wood, Manohar Garg, Peter Gibson
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric restriction and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research & Clinical Practice (2010) [E3]
Co-authors Peter Gibson, Lisa Wood, Robin Callister, Manohar Garg, Philip Morgan
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric consumption and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research and Clinical Practice (2010) [E3]
Co-authors Manohar Garg, Peter Gibson, Philip Morgan, Robin Callister, Lisa Wood
2010 Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved by caloric restriction and exercise in overweight and obese asthma', Proceedings of the Nutrition Society of Australia (2010) [E3]
Co-authors Robin Callister, Peter Gibson, Philip Morgan, Lisa Wood, Manohar Garg
2009 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Plasma fatty acid profiles are different in obese versus non-obese asthma', Proceedings of the Nutrition Society of Australia (2009) [E3]
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
2009 Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Neutrophilic Airway Inflammation Links Asthma and Obesity', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
Co-authors Lisa Wood, Peter Gibson, Manohar Garg
2009 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Asthma and obesity are linked via neutrophilic airway inflammation', Respirology (2009) [E3]
DOI 10.1111/j.1440-1843.2009.01503_1.x
Co-authors Lisa Wood, Manohar Garg, Peter Gibson
2008 Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Obesity is associated with increased inflammation in asthma', Asia Pacific Journal of Clinical Nutrition (2008) [E3]
Co-authors Peter Gibson, Lisa Wood, Manohar Garg
Show 24 more conferences
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Grants and Funding

Summary

Number of grants 8
Total funding $355,725

Click on a grant title below to expand the full details for that specific grant.


20161 grants / $88,358

Improving asthma through lifestyle interventions: how much exercise is best?$88,358

Funding body: Asthma Australia

Funding body Asthma Australia
Project Team Professor John Upham, Doctor Hayley Scott, Professor Lisa Wood
Scheme National Research Program
Role Investigator
Funding Start 2016
Funding Finish 2018
GNo G1600405
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20144 grants / $218,648

Understanding the Beneficial Role of Exercise in Modifying Eosinophilic Airway Inflammation in Asthma$160,000

This project will examine the concept that exercise assists in optimising asthma management. While it is well established that exercise has multiple benefits on general health, relatively little attention has been paid to the potential therapeutic effects of exercise in modifying inflammation in asthma. We have recently published a study showing that moderate-intensity aerobic exercise can reduce airway eosinophilia in adults with asthma. This project will build on this exciting data, by examining the importance of exercise intensity and assessing the mechanisms through which exercise exerts these beneficial effects.

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team

Dr Hayley Scott

Scheme Postdoctoral Respiratory Research Fellowship
Role Lead
Funding Start 2014
Funding Finish 2016
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

Greaves Family Early Career Support Grant$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Hayley Scott
Scheme Bridging Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301292
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Exercise Training as a Potential Treatment for Eosinophilic Airway Inflammation in Asthma$26,648

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Hayley Scott, Professor Lisa Wood, Conjoint Associate Professor Nick Saltos
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400219
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

12th International congress on Obesity, Kuala Lumpur Malaysia, 17-20 March 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Hayley Scott
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400427
Type Of Funding Internal
Category INTE
UON Y

20131 grants / $23,810

The Effect of Exercise on Asthmatic Airway Inflammation$23,810

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Hayley Scott, Conjoint Associate Professor Nick Saltos
Scheme Research Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300780
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20122 grants / $24,909

Follow-Up of a Weight Loss Intervention in COPD$14,989

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Professor Lisa Wood, Doctor Hayley Scott, Emeritus Professor Michael Hensley
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2013
GNo G1200763
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

The Role of Sex Hormones and Leptin in Obese-Asthma$9,920

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Hayley Scott
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200809
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed3
Current0

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2014 Honours Evaluation of a weight loss intervention in obese COPD subjects
Nutrition & Dietetics, University of Newcastle
Co-Supervisor
2014 Honours Effect of Exercise on Asthmatic Airway Inflammation
Medical Science, University of Newcastle
Co-Supervisor
2013 Honours Adipokines and the role in overweight and obese asthma
Nutrition & Dietetics, University of Newcastle
Co-Supervisor
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News

Associate Professor Vanessa McDonald

Weight-loss study challenges COPD’s obesity puzzle

February 29, 2016

Faced with a clinical paradox where obesity seemingly offers a protective effect for Chronic Obstructive Pulmonary Disease (COPD), Hunter researchers have performed a world-first pilot study aimed at achieving weight loss without exacerbating respiratory symptoms.

Dr Hayley Scott

Positions

Conjoint Fellow
Centre for Healthy Lungs
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Research Assistant
Centre for Healthy Lungs
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email hayley.scott@newcastle.edu.au

Office

Room Level 2 West
Building Hunter Medical Research Institute
Location Lot 1 Kookaburra Circuit, New Lambton Heights NSW 2305

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