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Biography

Dr Scott is a Conjoint Postdoctoral Research Fellow for the Priority Research Centre in Asthma and Respiratory Diseases, while she completes her postdoctoral studies at the Lung and Allergy Research Centre at the University of Queensland. Her research investigates the roles of obesity, exercise and nutrition in promoting or impeding inflammation and, ultimately, the effect this has on the pathogenesis of respiratory diseases including asthma and COPD.

 

She was the first internationally to demonstrate an inflammatory mechanism driving the association between obesity and asthma, and has also investigated whether weight loss (by dietary restriction and/or increasing exercise) is a potential treatment strategy for obese asthmatics. This study found that loss of fat tissue within the gynoid region is associated with a reduction to airway inflammation in females, while in males a reduced dietary intake of saturated fat was associated with a reduction to airway inflammation. This suggests that these changes are operating via different mechanisms in males versus females and, importantly, the obese-asthma association is responsive to dietary manipulation. Hayley has also investigated the potential therapeutic effects of exercise in asthma and found that a 10-week exercise training program resulted in a significant 5-fold reduction to airway inflammation and improved asthma-related quality of life. Her research was the first to establish that a 5-10% weight loss is associated with clinically important improvements to asthma control in 58% of patients and asthma-related quality of life in 83% of patients. Prior to this there was no specific weight loss target for obese asthmatics, and since its publication has been translated into practice as the target weight loss goal published in the “Asthma and Healthy Living” brochures by the National Asthma Council Australia, which is distributed to both general practitioners and patients nationally. More recently, Dr Scott has expanded her research into elucidating the role of exercise in reducing asthmatic airway inflammation and found that a one-off exercise session reduces inflammation in the airways, which has led her to commence an RCT as part of her postdoctoral studies aimed at elucidating whether exercise intensity impacts the response to exercise in those with asthma.

 

Dr Scott's qualification as a dietitian positions her uniquely within the field, as she is able to perform specialised dietary manipulations to achieve a desired clinical outcome. For example, she recently performed weight loss counselling in 30 adults with COPD, achieving an average weight loss of 10% in 3 months, maintenance of lean muscle mass and corresponding clinically important improvement in several disease outcomes linked with morbidity and mortality. She has also performed weight loss counselling in patients with asthma resulting in an average weight loss of 8% in 10 weeks, with significant improvements to asthma symptoms and asthma-related quality of life, as well as completed dietary manipulation of antioxidants, which modified patients risk of experiencing an asthma exacerbation. She has expertise in many specialised clinical techniques including venepuncture, hypertonic saline challenge and sputum collection, body composition and bone density analysis using dual-energy x-ray absorptiometry (DXA) and lung function testing, while her research utilises advanced laboratory techniques including measuring gene expression, and HPLC and GC for quantifying nutritional markers such as antioxidants and fatty acids. 

Qualifications

  • PhD, University of Newcastle, 20/02/2012
  • Bachelor of Nutrition and Dietetics (Honours), University of Newcastle, 11/12/2006

Research

Research keywords

  • Asthma
  • Fatty acids
  • Inflammation
  • Nutrition
  • Obesity
  • Respiratory Disease

Research expertise

Dr Scott is a Conjoint Postdoctoral Research Fellow for the Priority Research Centre in Asthma and Respiratory Diseases, while she is undertaking postdoctoral research at the Lung and Allergy Research Centre at the University of Queensland. Hayley completed her PhD in 2012, which sought to examine the mechanisms driving the association between obesity and asthma. This research was the first internationally to propose a plausible inflammatory mechanism driving the association between obesity and asthma. She then utilised her skills as a dietitian to design and undertake a randomised trial, where she examined the effects of weight loss in those with asthma to examine whether the detrimental effects of obesity in asthma could be reversed. This study was the first internationally to propose that a 5-10% weight loss was associated with clinically important improvements to asthma in most patients, and since its publication has been incorporated as a weight loss goal in the “Asthma and Healthy Living” brochures by the National Asthma Council Australia, which has been distributed to both general practitioners and patients nationally.

Dr Scott's research has identified three common drivers of the obese-asthma phenotype, which her research focuses on:

1. Excess fat tissue: Dr Scott's research has shown that adiposity is associated with neutrophilic airway inflammation in those with asthma. When examined by sex, this relationship is only apparent in females, while weight loss reduces this inflammation in females. Neutrophilic airway inflammation is associated with the most severe forms of asthma and is not responsive to inhaled corticosteroid medications, the mainstay of asthma pharmacotherapy. Dr Scott is undertaking research to examine the hormonal drivers of this sex-specific effect with the hope of identifying alternate treatment options.

2. Exercise: Obesity is often associated with a low level of exercise. Dr Scott's research has shown that 10 weeks of exercise results in a five-fold reduction in eosinophilic airway inflammation, suggesting exercise is an important adjuvant asthma therapy and may be particularly useful for those who are refractory to current asthma therapies. Hayley is now conducting a randomised controlled trial aimed at elucidating how exercise intensity may have different inflammatory effects in those with asthma.

3. Dietary fat: Obesity is also often associated with a high dietary fat intake, with Dr Scott's research indicating that a high dietary fat intake is associated with increased neutrophilic airway inflammation in males with asthma, while restricting dietary fat intake is associated with a reduction in neutrophilic airway inflammation in males, suggesting reversibility of this phenomenon.

The excellence of Dr Scott’s work has been recognised externally as she was awarded the Emerging Researcher for 2011 by the Nestle Nutrition Institute and Nutrition Society of Australia (NSA). More recently she was awarded the NSA Early Career Travel Grant, and has been awarded five conference travel awards since 2008. She was Chair of the Nutrition Society of Australia (Newcastle Branch) in 2012-2014, but in 2015 she stepped down to expand her postdoctoral research in Brisbane. Her research goal is to utilise her expertise in nutrition, weight loss counselling, exercise, body composition analysis and respiratory disease to ensure we gain a better understanding of the independent roles of obesity, exercise and dietary factors in driving respiratory disease outcomes, to enable optimisation of the clinical management of this population.

Fields of Research

CodeDescriptionPercentage
110199Medical Biochemistry And Metabolomics Not Elsewhere Classified50
110203Respiratory Diseases50
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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2013Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial', Clinical and Experimental Allergy, 43 36-49 (2013) [C1]
2011Scott HA, Gibson PG, Garg ML, Wood LG, 'Airway inflammation is augmented by obesity and fatty acids in asthma', European Respiratory Journal, 38 594-602 (2011) [C1]
2013Scott H, Wood LG, Garg ML, Gibson PG, 'Asthma and Inflammation', Nutrition and Physical activity in inflammatory diseases, CABI, Oxford, UK 299-321 (2013) [B1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2013Scott H, Wood LG, Garg ML, Gibson PG, 'Asthma and Inflammation', Nutrition and Physical activity in inflammatory diseases, CABI, Oxford, UK 299-321 (2013) [B1]

Journal article (12 outputs)

YearCitationAltmetricsLink
2015Periyalil HA, Wood LG, Scott HA, Jensen ME, Gibson PG, 'Macrophage activation, age and sex effects of immunometabolism in obese asthma', EUROPEAN RESPIRATORY JOURNAL, 45 388-395 (2015)
2015Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Determinants of weight loss success utilizing a meal replacement plan and/or exercise, in overweight and obese adults with asthma.', Respirology, 20 243-250 (2015)
2014Morgan PJ, Scott HA, Young MD, Plotnikoff RC, Collins CE, Callister R, 'Associations between program outcomes and adherence to Social Cognitive Theory tasks: process evaluation of the SHED-IT community weight loss trial for men', INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY, 11 (2014) [C1]
2014Scott HA, Jensen ME, Wood LG, 'Dietary interventions in asthma', Current Pharmaceutical Design, 20 1003-1010 (2014)
2013Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial', Clinical and Experimental Allergy, 43 36-49 (2013) [C1]
2013Morgan PJ, Barnett LM, Cliff DP, Okely AD, Scott HA, Cohen KE, Lubans DR, 'Fundamental movement skill interventions in youth: A systematic review and meta-analysis', Pediatrics, 132 (2013) [C1]
2012Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized controlled trial', American Journal of Clinical Nutrition, 96 534-543 (2012) [C1]
2012Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma', Chest, 142 86-93 (2012) [C1]
2012Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Relationship between body composition, inflammation and lung function in overweight and obese asthma', Respiratory Research, 13 1-10 (2012) [C1]
2011Scott HA, Gibson PG, Garg ML, Wood LG, 'Airway inflammation is augmented by obesity and fatty acids in asthma', European Respiratory Journal, 38 594-602 (2011) [C1]
2009McFarlane J, Scott HA, Robertson VJ, Gleeson C, Vanderkroft D, Wilson K, 'General practitioner and paediatrician self-reported capacity for the diagnosis and management of childhood and adolescent overweight and obesity', Nutrition & Dietetics, 66 176-185 (2009) [C1]
2009Wood LG, Scott HA, Garg ML, Gibson PG, 'Innate immune mechanisms linking non-esterified fatty acids and respiratory disease', Progress in Lipid Research, 48 27-43 (2009) [C1]
Show 9 more

Conference (26 outputs)

YearCitationAltmetricsLink
2014Periyalil H, Scott H, Jensen M, Wood L, Gibson P, 'MACROPHAGE ACTIVATION IS A DETERMINANT OF DEVELOPMENTAL EFFECTS OF IMMUNOMETABOLISM IN OBESE ASTHMA', RESPIROLOGY (2014) [E3]
2014Mcdonald V, Gibson P, Scott H, Baines P, Hensley M, Pretto J, Wood L, 'SHOULD WE TREAT OBESITY IN COPD? THE EFFECTS OF WEIGHT LOSS AND RESISTANCE TRAINING IN OBESE COPD', RESPIROLOGY (2014) [E3]
2013Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'REPRODUCTIVE STAGE DRIVES LINK BETWEEN OBESITY AND NEUTROPHILIC AIRWAY INFLAMMATION IN FEMALES WITH ASTHMA', RESPIROLOGY (2013) [E3]
2013Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'The Association Between Obesity and Asthma is Driven By Female Reproductive Stage', Australasian Medical Journal, Brisbane (2013) [E3]
2013Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Female Reproductive Stage Drives The Association Between Obesity And Neutrophilic Airway Inflammation In Adults With Asthma', American Journal of Respiratory and Critical Care Medicine, Philadelphia, PA (2013) [E3]
2012Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Female reproductive stage drives the association between obesity and neutrophilic airway inflammation in adults with asthma', Abstracts. American Thoracic Society 2012 International Conference, San Francisco, CA (2012) [E3]
2012Wood LG, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG, 'Manipulating antioxidant intake in asthma: A randomized clinical trial', Respirology, Canberra, ACT (2012) [E3]
2012Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Weight loss improves clinical asthma outcomes and airway inflammation in overweight and obese asthmatics', Obesity Research & Clinical Practice, Auckland, New Zealand (2012) [E3]
2012Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Reproductive stage drives link between obesity and neutrophilic airway inflammation in females with asthma', Abstracts. TSANZ Annual Scientific Meeting 2012, Canberra, ACT (2012) [E3]
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is greatest in subjects with more severe asthma', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2011Fu J, Baines KJ, Gibson PG, Scott HA, Wood LG, 'Systemic inflammation mediates airway neutrophilia via the regulation of IL-8 receptor mRNA expression', Respirology, Shanghai (2011) [E3]
2011Fu J, Baines KJ, Wood LG, Scott HA, Gibson PG, 'Low-grade systemic inflammation is associated with airway neutrophilia in asthma', Respirology, Shanghai (2011) [E3]
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'The influence of body composition and inflammation on lung function in asthma', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
2011Wood LG, Scott HA, Gibson PG, 'Systemic inflammation is increased in neutrophilic asthma', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]

Co-authors: LISA WOOD, PETER GIBSON

2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved after body fat reduction in overweight and obese asthmatics', American Journal of Respiratory and Critical Care Medicine, Denver, CO (2011) [E3]
2011Wood LG, Scott HA, Gibson PG, 'The neutrophilic inflammatory phenotype is associated increased systemic inflammation in asthma', Respirology, Perth, WA (2011) [E3]

Co-authors: LISA WOOD, PETER GIBSON

2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Body fat reduction improves clinical asthma outcomes in overweight and obese asthma', Respirology, Perth, WA (2011) [E3]
2011Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Success in a weight loss trial is related to asthma severity', Respirology, Perth, WA (2011) [E3]
2010Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric restriction and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research & Clinical Practice, Sydney, NSW (2010) [E3]
2010Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Caloric consumption and exercise improve clinical asthma outcomes in overweight and obese asthma', Obesity Research and Clinical Practice, Sydney, NSW (2010) [E3]
2010Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Fatty acids and obesity differentially affect airway inflammation in males and females with asthma', American Journal of Respiratory and Critical Care Medicine, New Orleans (2010) [E3]
2010Scott HA, Gibson PG, Garg ML, Pretto JJ, Morgan PJ, Callister R, Wood LG, 'Clinical asthma outcomes are improved by caloric restriction and exercise in overweight and obese asthma', Proceedings of the Nutrition Society of Australia, Perth (2010) [E3]
2009Scott HA, Gibson PG, Garg ML, Smart J, Wood LG, 'Neutrophilic Airway Inflammation Links Asthma and Obesity', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009) [E3]
2009Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Asthma and obesity are linked via neutrophilic airway inflammation', Respirology, Darwin, NT (2009) [E3]
2009Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Plasma fatty acid profiles are different in obese versus non-obese asthma', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
2008Scott HA, Gibson PG, Garg ML, Smart JM, Wood LG, 'Obesity is associated with increased inflammation in asthma', Asia Pacific Journal of Clinical Nutrition, Adelaide, SA (2008) [E3]
Show 23 more
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Grants and Funding

Summary

Number of grants7
Total funding$267,367

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (4 grants)

Understanding the Beneficial Role of Exercise in Modifying Eosinophilic Airway Inflammation in Asthma$160,000
Funding Body: Thoracic Society of Australia and New Zealand

SchemeRole
Postdoctoral Respiratory Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$160,00020142016
GNo:188687127

Greaves Family Early Career Support Grant$30,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Hayley Scott
SchemeRole
Bridging GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020142014
GNo:G1301292

Exercise Training as a Potential Treatment for Eosinophilic Airway Inflammation in Asthma$26,648
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Hayley Scott, Associate Professor Lisa Wood, Conjoint Associate Professor Nick Saltos
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$26,64820142014
GNo:G1400219

12th International congress on Obesity, Kuala Lumpur Malaysia, 17-20 March 2014$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Hayley Scott
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020142014
GNo:G1400427

2013 (1 grants)

The Effect of Exercise on Asthmatic Airway Inflammation$23,810
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Hayley Scott, Conjoint Associate Professor Nick Saltos
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$23,81020132013
GNo:G1300780

2012 (2 grants)

Follow-Up of a Weight Loss Intervention in COPD$14,989
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Associate Professor Lisa Wood, Doctor Hayley Scott, Emeritus Professor Michael Hensley
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$14,98920122013
GNo:G1200763

The Role of Sex Hormones and Leptin in Obese-Asthma$9,920
Funding Body: University of Newcastle

Project Team
Doctor Hayley Scott
SchemeRole
Early Career Researcher GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,92020122012
GNo:G1200809
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Research Supervision

Number of current supervisions0

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Past Supervision

YearProgramSupervisor TypeResearch Title
2014Honours Nutrition & Dietetics
University of Newcastle
Co-SupervisorEvaluation of a weight loss intervention in obese COPD subjects
2014Honours Medical Science
University of Newcastle
Co-SupervisorEffect of Exercise on Asthmatic Airway Inflammation
2013Honours Nutrition & Dietetics
University of Newcastle
Co-SupervisorAdipokines and the role in overweight and obese asthma
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Dr Hayley Scott

Work Phone07 3443 7126
Fax07 3443 7779
Email
PositionConjoint Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Office
Level 5 West,
Translational Research Institute,
Lung and Allergy Research Centre. 37 Kent Street, Woolloongabba QLD 4102
URL:www.newcastle.edu.au/profile/hayley-scott